Journal of oral biology and craniofacial research最新文献_第6页

Flourishing systematic reviews, but is evidence keeping pace? A critical evaluation and trend analysis of five orthodontic journals from 2015 to 2024 系统评价蓬勃发展，但证据跟上了吗？2015 - 2024年5家口腔正畸期刊批判性评价及趋势分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-01 Epub Date: 2025-12-31 DOI: 10.1016/j.jobcr.2025.12.008

J. Monisha, Balasubramanian Madhan

Introduction

Systematic reviews and meta-analyses (SRMAs) in Orthodontics have increased substantially, but whether this is commensurate with the evidence generated is questionable.

Objective

To evaluate the evidence outcome from SRMAs, the quality of included primary studies, and the proportion of SRMAs to original research in five orthodontic journals from 2015 to 2024.

Methods

SRMAs in Progress in Orthodontics (PO), Angle Orthodontist (AO), European Journal of Orthodontics (EJO), American Journal of Orthodontics and Dentofacial Orthopedics (AJODO), and Journal of the World Federation of Orthodontists (JWFO) published during this period were evaluated for the evidence outcome and Risk of Bias (RoB) of included studies. The proportion of SRMAs to original research was also calculated, and trends were compared across two five-year periods (2015–2019 and 2020–2024).

Results

During this period, 292 SRMAs evaluating 4511 studies for 707 outcomes were published. Of the evaluated outcomes, 16.7 % were fully conclusive, 69.2 % partially conclusive, and 14.1 % inconclusive. Most included studies (n = 3149) showed moderate (37.4 %) or high (32.3 %) RoB. Of all evaluated publications (n = 3904), 7.5 % were SRMAs. Some journals showed an increase in partially conclusive outcomes (AO, JWFO), the proportion of SRMA (EJO), and studies with high RoB, as well as a drop in fully conclusive outcomes (AO, AJODO, PO) in the latter half. However, overall differences remained statistically nonsignificant.

Conclusion

Though maintaining the proportion of SRMA to primary research by most journals is comforting, the SRMAs staying less productive in evidence, and primary research with high RoB are a matter of concern.

正畸学的系统综述和荟萃分析（srma）已大幅增加，但这是否与所产生的证据相称尚存疑问。目的评价2015 - 2024年5份口腔正畸期刊srma的证据结果、纳入的初步研究质量以及srma占原创研究的比例。方法对同期发表在《Progress in Orthodontics》（PO）、《Angle Orthodontist》（AO）、《European Journal of Orthodontics》（EJO）、《American Journal of orthotics and Dentofacial Orthopedics》（AJODO）和《Journal of World Federation of Orthodontists》（JWFO）上的ssrma进行纳入研究的证据结局和偏倚风险（Risk of Bias, RoB）评价。还计算了srma与原始研究的比例，并比较了两个五年期（2015-2019年和2020-2024年）的趋势。在此期间，共发表了292篇srma，评估了4511项研究的707个结果。在评估的结果中，16.7%是完全结论性的，69.2%是部分结论性的，14.1%是非结论性的。大多数纳入的研究（n = 3149）显示中度（37.4%）或高（32.3%）的RoB。在所有被评估的出版物（n = 3904）中，7.5%为srma。部分期刊显示部分结论性结果（AO、JWFO）、SRMA （EJO）和高RoB的研究比例增加，而完全结论性结果（AO、AJODO、PO）在后半段有所下降。然而，总体差异在统计学上仍然不显著。结论虽然大多数期刊保持SRMA在初级研究中的比例令人欣慰，但SRMA在证据方面的生产力仍然较低，初级研究的高RoB是值得关注的问题。

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引用次数: 0

Diagnostic accuracy of artificial intelligence in the diagnosis of pemphigus and pemphigoid groups of disorders based on clinical images: A systematic review and meta-analysis 基于临床图像的人工智能诊断天疱疮和类天疱疮组疾病的准确性：系统回顾和荟萃分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-01 Epub Date: 2025-11-08 DOI: 10.1016/j.jobcr.2025.10.023

Pravallika Kakada, Monal Yuwanati, Pratibha Ramani

Background

Pemphigus and pemphigoid disease pose diagnostic challenges to pathologists and clinician due to overlapping clinical and histopathological features. The systematic review evaluated the diagnostic accuracy of artificial intelligence (AI) in identifying pemphigus and pemphigoid disorders based on clinical images, compared to conventional diagnostic techniques.

Methods

A search was carried out in PubMed, Scopus, and Web of Science databases since inception using search strategy comprising of "Artificial Intelligence", "Pemphigus", "Pemphigoid", "Diagnosis", "sensitivity", "specificity", and "accuracy". Studies examined AI models’ accuracy for diagnosing pemphigus and pemphigoid were included in the review. A meta-analysis was conducted using Meta-Disc software, with pooled sensitivity, specificity, and summary receiver operating characteristic (SROC) curve analysis.

Results

Out of 4094 search results, five studies met the eligibility criteria after screening and selection steps. The pooled diagnostic accuracy of AI-based systems was 0.83 (CI 0.73–0.90) with a of 0.86 % (CI: 0.76–0.91) pooled sensitivity and 0.84 % (CI: 0.79–0.87) pooled specificity, reflecting its moderate effectiveness in ruling out pemphigus and pemphigoid disorders. Further, the positive likelihood ratio (PLR) was 5.34 (95 % CI: 4.05–7.05), and the negative likelihood ratio (NLR) was 0.16 (95 % CI: 0.09–0.28), with a DOR of 32.53 (95 % CI: 14.70–71.94) indicates moderate to strong accuracy.

Conclusion

AI have moderate diagnostic efficacy in diagnosis of pemphigus and pemphigoid diseases. However, additional research is needed to develop standardized methodologies and ensure generalizability across different populations before integrating into clinical practice.

天疱疮和类天疱疮疾病由于重叠的临床和组织病理学特征给病理学家和临床医生提出了诊断挑战。与传统诊断技术相比，系统评价了人工智能（AI）在基于临床图像识别天疱疮和类天疱疮疾病方面的诊断准确性。方法采用人工智能（Artificial Intelligence）、天疱疮（Pemphigus）、类天疱疮（Pemphigoid）、诊断（Diagnosis）、敏感性（sensitivity）、特异性（specificity）、准确性（accuracy）等检索策略，对PubMed、Scopus和Web of Science数据库进行检索。研究人工智能模型诊断天疱疮和类天疱疮的准确性被纳入综述。采用Meta-Disc软件进行meta分析，合并敏感性、特异性和总受试者工作特征（SROC）曲线分析。结果在4094个检索结果中，经过筛选和选择步骤，有5个研究符合资格标准。人工智能系统的综合诊断准确率为0.83 (CI 0.73-0.90)，综合敏感性为0.86% (CI: 0.76-0.91)，综合特异性为0.84% (CI: 0.79-0.87)，反映了其在排除天疱疮和类天疱疮疾病方面的中等有效性。此外，阳性似然比（PLR）为5.34 (95% CI: 4.05-7.05)，阴性似然比（NLR）为0.16 (95% CI: 0.09-0.28)， DOR为32.53 (95% CI: 14.70-71.94)，表明准确度中等至高。结论人工智能对天疱疮及类天疱疮疾病的诊断有中等疗效。然而，在纳入临床实践之前，需要进一步的研究来开发标准化的方法并确保在不同人群中的普遍性。

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引用次数: 0

The influence of salivary contamination during light curing on degree of conversion and color stability of two composite resins 光固化过程中唾液污染对两种复合树脂转化度和颜色稳定性的影响

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-01 Epub Date: 2025-12-24 DOI: 10.1016/j.jobcr.2025.12.009

Marzieh Rohaninasab , Shima Falahat , Golnaz Tayebi , Farzaneh Manouchehri , Farzaneh Sadeghi Mahounak

Background

Adequate polymerization of composite resin restorations is critical for their mechanical performance and long-term clinical success. Salivary contamination during light curing can interfere with polymerization and may influence color stability.

Objective

This in vitro study examined how artificial saliva contamination at specific intervals during light curing affects the DC (degree of conversion) and short-term color change or ΔE (Delta E) of two composite resins—Gradia Direct (microhybrid) and N-Ceram Bulk Fill (nanohybrid).

Methods

One hundred eighty disk specimens (n = 90 per composite) were allocated into nine experimental groups differing in contamination timing and curing duration. DC was determined by FTIR-ATR (Fourier-Transform Infrared- Attenuated Total Reflectance) spectroscopy immediately after curing and following 24-h incubation at 37 °C. Color change (ΔE) was measured with a spectrophotometer using the CIE (International Commission on Illumination) Lab∗ system. Statistical analysis employed one- and two-way ANOVA (Analysis of Variance) with Tukey's post hoc test (α = 0.05).

Results

Early contamination (within the first 5–10 s) produced a significant reduction in DC for both materials (p < 0.001), with N-Ceram showing the greatest loss. Gradia achieved higher DC across most conditions. Post-cure incubation improved DC in all groups, most notably in N-Ceram. All ΔE values remained below the perceptibility threshold of 3.3, with no significant differences among groups (p > 0.05).

Conclusion

Saliva exposure early in light curing markedly reduces polymerization efficiency, although extended curing and post-cure polymerization can partially restore DC. Short-term color stability appears unaffected. Strict field isolation and optimized curing protocols are essential to maximize clinical performance.

复合树脂修复体的充分聚合对其力学性能和长期临床成功至关重要。光固化过程中的唾液污染会干扰聚合，并可能影响颜色稳定性。目的研究光固化过程中特定时间内人工唾液污染对梯度直接树脂（微杂交）和n -陶瓷填充树脂（纳米杂交）的DC（转化度）和短期颜色变化或ΔE （Delta E）的影响。方法将180个圆盘标本按污染时间和养护时间的不同分为9个实验组，每组90个。固化后立即和37°C孵育24小时后，通过FTIR-ATR（傅里叶变换红外衰减全反射）光谱测定DC。颜色变化（ΔE）用分光光度计测量使用CIE（国际照明委员会）实验室∗系统。统计分析采用单因素和双因素方差分析（方差分析），采用Tukey事后检验（α = 0.05）。结果早期污染（在前5-10秒内）使两种材料的DC显著降低（p < 0.001），其中n -陶瓷的损失最大。在大多数情况下，gradient都实现了更高的DC。固化后的孵育改善了所有组的DC，尤其是N-Ceram组。所有ΔE值均低于3.3的感知阈值，组间差异无统计学意义（p > 0.05）。结论光固化早期唾液暴露明显降低聚合效率，但延长固化时间和固化后的聚合可以部分恢复DC。短期颜色稳定性似乎不受影响。严格的现场隔离和优化的治疗方案是必不可少的，以最大限度地提高临床表现。

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引用次数: 0

In-vitro evaluation of shear bond strength and bond-failure of isoamyl cyanoacrylate-resin adhesive ratios for bonding 3D-Printed denture bases and teeth 体外评价3d打印义齿基托与牙齿的剪切粘接强度和粘接破坏

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1016/j.jobcr.2025.11.017

Divyansh Sinha, Ram Kiran, Suresh Venugopalan

Statement of problem

Shear bond strength between 3D-printed denture bases and teeth is inferior compared to conventional and milled dentures.

Purpose

The success of 3D-printed complete dentures depends on reliable bonding between the denture base and teeth. This study evaluated shear bond strength and modes of bond failure of various isoamyl cyanoacrylate (ICA) and 3D printing resin formulations in different ratios.

Materials and methods

Adhesive formulations of standardized ICA-to-resin ratios were prepared. Fifty samples were randomized into five groups: 0 % (control), 25 %, 50 %, 75 %, and 100 % ICA. Specimens were fabricated per ISO/TS 19736 standards using 3D-printed denture base and tooth resins. After bonding and polymerization, samples underwent shear bond strength testing. Failure modes were examined under stereomicroscope and classified as adhesive, cohesive, or mixed. Data were analyzed using one-way ANOVA with Tukey's post hoc test.

Results

The 50 % ICA group showed the highest mean shear bond strength (3.738 ± 0.063 MPa), significantly greater than all others (P = 0.000). The control group exhibited the lowest strength (1.602 ± 0.140 MPa). Bond failure analysis showed predominantly adhesive failures in the control, whereas the 50 % ICA group had the greatest proportion of cohesive and mixed failures, indicating improved interfacial bonding and internal strength.

Conclusions

A 50:50 ratio of isoamyl cyanoacrylate and light-cure 3D printing resin provides optimal bond strength and favorable failure patterns for bonding 3D-printed denture bases and teeth suggesting that a hybrid adhesive approach offers a promising solution to enhance the durability of 3D-printed dentures.

问题陈述3d打印义齿基托和牙齿之间的剪切结合强度不如传统和磨假牙。目的3d打印全口义齿的成功与否取决于义齿基托与牙齿之间的可靠结合。本研究评估了不同比例的氰基丙烯酸酯异戊酯（ICA）和3D打印树脂配方的剪切粘结强度和粘结破坏模式。材料与方法制备了标准ica -树脂配比的胶粘剂配方。50例样本随机分为5组：0%（对照）、25%、50%、75%和100% ICA。使用3d打印义齿基托和牙树脂，按照ISO/TS 19736标准制作标本。粘结聚合后，试样进行剪切粘结强度测试。在体视显微镜下检查了破坏模式，并将其分为粘接、内聚或混合。数据分析采用单因素方差分析和Tukey事后检验。结果50% ICA组的平均剪切强度最高（3.738±0.063 MPa），显著高于其他各组（P = 0.000）。对照组强度最低（1.602±0.140 MPa）。粘合失效分析显示，在对照组中主要是粘合失效，而50%的ICA组有最大比例的内聚和混合失效，表明界面粘合和内部强度得到改善。结论50:50比例的氰基丙烯酸酯异戊酯和光固化3D打印树脂可以为3D打印义齿基托与牙齿的粘接提供最佳的粘接强度和良好的失效模式，表明混合粘接方法是提高3D打印义齿耐久性的一种有前景的解决方案。

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引用次数: 0

Comparative evaluation of breathing convenience and clinical acceptance of a new patented mouth breathing device for rubber dam: A randomized clinical study 一种新型橡胶坝口呼吸装置的呼吸便利性和临床接受度的比较评价：一项随机临床研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-01 Epub Date: 2025-11-28 DOI: 10.1016/j.jobcr.2025.11.013

Geetanjali Jain, Ajay Singh Rao, Shreya Volety, Vidula Bhandary, Rutvi Karande

Introduction

The rubber dam isolation technique is widely used in endodontics to improve visibility and access, yet it often causes patient discomfort, especially for those with difficulty breathing through their nose. To address this, a new patented mouth breathing device (MBD) was developed to enhance patient comfort by facilitating easier mouth breathing during rubber dam isolation. This study aims to evaluate the breathing convenience and clinical acceptance of the MBD.

Methods

In a randomized clinical trial, 36 patients undergoing endodontic procedures with rubber dam isolation were recruited. Participants were randomly assigned to either the experimental group (MBD) or the control group (no device). A custom-developed questionnaire was used to assess patient comfort, ease of breathing, and overall satisfaction with the procedure. Clinicians also provided feedback on the device's impact on treatment efficiency, patient cooperation, and clinical outcomes. Data were analyzed using statistical tests to compare the results between the two groups.

Results

The study evaluated 36 participants, evenly divided into two groups with a significant age difference (p = 0.04). Group A (Test) showed improved outcomes, including reduced blood pressure (SBP: 14.12 mmHg, DBP: 16.76 mmHg) and increased oxygen saturation (SpO2: +5.71 %, p < 0.001). In contrast, Group B (Control) showed worsened outcomes with increased blood pressure and decreased SpO2 (−6.12 %, p < 0.001).

Conclusion

The patented mouth breathing device offers significant benefits in terms of breathing convenience and patient comfort during rubber dam isolation. The device appears to be a promising adjunct to improve clinical outcomes by reducing patient anxiety and discomfort.

橡胶坝隔离技术广泛应用于牙髓学，以提高可视性和可及性，但它经常引起患者不适，特别是对那些通过鼻子呼吸困难的患者。为了解决这个问题，一种新的口腔呼吸装置（MBD）被开发出来，通过在橡胶坝隔离期间促进更容易的口腔呼吸来提高患者的舒适度。本研究旨在评估MBD的呼吸便利性和临床接受度。方法采用随机临床试验方法，选取36例采用橡胶坝隔离术的根管治疗患者。参与者被随机分配到实验组（MBD）或对照组（无设备）。使用定制开发的问卷来评估患者的舒适度、呼吸的轻松程度和对手术的总体满意度。临床医生还就该设备对治疗效率、患者合作和临床结果的影响提供了反馈。采用统计学检验对数据进行分析，比较两组结果。结果本研究共评估了36名参与者，平均分为两组，年龄差异显著（p = 0.04）。A组（试验）表现出改善的结果，包括血压降低（收缩压：14.12 mmHg，舒张压：16.76 mmHg）和血氧饱和度升高（SpO2: + 5.71%, p < 0.001）。相比之下，B组（对照组）的预后恶化，血压升高，SpO2降低（- 6.12%,p < 0.001）。结论本发明专利口腔呼吸装置在橡胶坝隔离术中呼吸方便，患者舒适度显著提高。该设备似乎是一种很有希望的辅助手段，可以通过减少患者的焦虑和不适来改善临床结果。

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引用次数: 0

Evaluation of dentinal tubule occlusion by Fluoridated and Non-fluoridated Bioactive Glass and Propolis desensitizers by scanning electron microscopy 扫描电镜评价含氟和非含氟生物活性玻璃和蜂胶脱敏剂对牙本质小管闭塞的影响

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-01 Epub Date: 2025-11-07 DOI: 10.1016/j.jobcr.2025.10.028

Athira Murali, Sapna Chandira Muddappa, Prabath Singh V P, Rakesh R. Rajan, Remya M, Gayathri Presannakumar

Objective

Dentin hypersensitivity is a worldwide epidemiological dental health issue, bioactive toothpaste has been demonstarted in alleviating dentin hypersensitivity along with propolis. Hence their comparison as desensitizing agents in dentinal tubule occlusion is carried out in this research. This study aimed to evaluate the efficacy of Fluoridated Bioactive Glass dentifrice, Non-fluoridated Bioactive Glass dentifrice, and Propolis containing dentifrice in dentinal tubule occlusion using scanning electron microscopy (SEM) and its resistance to acid.

Materials and methods

This is an In vitro study design with permanent maxillary and mandibular premolars, which were divided into four groups. Group 1 – Fluoridated bioactive glass (FBaG) Toothpaste; Group 2 – Bioactive glass (BaG) Toothpaste; Group 3 – Propolis Toothpaste; Group 4 – Saline. Dentin discs were obtained from the samples. 37 % phosphoric acid was used to etch and expose the dentinal tubules. Rubber cup was used to apply the desensitizing agent. Samples were then subjected to 6 % citric acid. The degree of occlusion was evaluated using SEM after application of desensitizing agent and after application of citric acid.

Results

Statistical analysis was calculated and results obtained showed that specimens treated with FBaG and BaG showed highest degree of tubule occlusion with a mean value of (2.33) followed by Propolis with mean values of (3.00) and least number of occluded tubules after application of desensitizing agent. Propolis showed highest degree of occlusion with a mean value of (2.33) followed by FBaG (2.66) and BaG (3.00) after application of citric acid.

Conclusion

Study concluded that FBaG and BaG-containing dentifrice showed a significant degree of dentinal tubule occlusion. Propolis demonstrated better resistance to acid attack.

目的牙本质过敏是一种世界性的流行病学口腔健康问题，生物活性牙膏与蜂胶在缓解牙本质过敏方面已得到证实。因此，本研究将它们作为牙本质小管闭塞的脱敏剂进行比较。本研究旨在通过扫描电镜（SEM）评价含氟生物活性玻璃牙膏、非含氟生物活性玻璃牙膏和含蜂胶牙膏在牙本质小管闭塞中的疗效及其耐酸性。材料与方法本研究采用上颌恒磨牙和下颌恒磨牙进行体外实验设计，将恒磨牙分为4组。第一组-含氟生物活性玻璃（FBaG）牙膏；第二组-生物活性玻璃（袋）牙膏；第三组-蜂胶牙膏；第4组：生理盐水。从样本中获得牙本质盘。37%磷酸用于牙本质小管的蚀刻和暴露。采用橡胶杯装脱敏剂。然后将样品置于6%柠檬酸中。应用脱敏剂和应用柠檬酸后，用扫描电镜评价闭塞程度。结果进行统计分析，结果显示FBaG和BaG处理的标本小管闭塞程度最高，平均值为（2.33），蜂胶次之，平均值为（3.00），使用脱敏剂后小管闭塞数量最少。蜂胶封堵程度最高，平均值为2.33，其次为FBaG(2.66)，柠檬酸封堵后为BaG（3.00）。结论FBaG及含bag牙体均存在明显程度的牙本质小管闭塞。蜂胶具有较好的抗酸性能。

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引用次数: 0

Dual pathway activation in wound repair: An in vitro study of betanin and theaflavin on periodontal ligament fibroblasts 伤口修复的双通路激活：甜菜素和茶黄素对牙周韧带成纤维细胞的体外研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI: 10.1016/j.jobcr.2025.10.020

Arwa Alihusain Kapasi , Taniya Mary Martin , Meenakshi Sundaram Kishore Kumar , Jayalakshmi Somasundaram , Kommireddy Vaishnavi

Background

Wound healing is a highly coordinated biological process involving inflammation resolution and neovascularization. Dysregulation of these processes can result in chronic wounds, especially in inflammatory or oxidative stress–rich environments. There is growing interest in natural compounds that can simultaneously promote angiogenesis and suppress inflammation to enhance wound healing outcomes.

Objective

This study aims to evaluate the synergistic wound-healing effects of betanin and theaflavin in vitro by assessing their ability to enhance cell viability, migration, and gene expression related to inflammation and angiogenesis in human periodontal ligament (PDL) fibroblasts.

Methods

PDL fibroblasts were treated with betanin, theaflavin, and their combinations at two concentrations (viz., 1, 5, 10, 25, 50, 75, 100, 125 μg/mL) were preliminary screened by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and based on the IC₅₀ values, further tested with two concentrations (10 μg/mL and 25 μg/mL, individually and in combination). The scratch assay was employed to evaluate fibroblast migration. To assess molecular changes, qRT-PCR was performed to quantify expression levels of VEGF-A, HIF-1α, NF-κB, IκBα, and IL-10.

Results

Combination treatment significantly enhanced cell viability and wound closure compared to individual treatments and controls. Gene expression analysis showed increased expression of VEGF-A and HIF-1α, indicating improved angiogenic potential. Concurrently, NF-κB expression was reduced, while IκBα and IL-10 were upregulated, indicating anti-inflammatory activity.

Conclusion

The combined use of betanin and theaflavin enhances in vitro wound healing by promoting angiogenesis and modulating inflammatory responses. This integrative strategy may offer a promising natural therapeutic approach for managing tissue repair in oral and dermal wounds.

伤口愈合是一个高度协调的生物过程，涉及炎症消退和新生血管。这些过程的失调可导致慢性伤口，特别是在炎症或氧化应激丰富的环境中。人们对能够同时促进血管生成和抑制炎症以提高伤口愈合效果的天然化合物越来越感兴趣。目的通过观察甜菜素和茶黄素对人牙周韧带成纤维细胞的细胞活力、迁移以及炎症和血管生成相关基因表达的影响，探讨其体外创面愈合的协同作用。方法采用3-（4,5-二甲基噻唑-2-基）-2,5-二苯基溴化四氮唑（MTT）法初步筛选甜菜素、茶黄素及其联用两种浓度（1、5、10、25、50、75、100、125 μg/mL）对spdl成纤维细胞的影响，并根据IC50值，分别以10 μg/mL和25 μg/mL单独和联合使用两种浓度进行检测。采用划痕法评价成纤维细胞的迁移。为了评估分子变化，采用qRT-PCR方法量化VEGF-A、HIF-1α、NF-κB、i -κB α和IL-10的表达水平。结果与单独治疗和对照组相比，联合治疗显著提高了细胞活力和伤口愈合。基因表达分析显示VEGF-A和HIF-1α表达增加，表明血管生成潜力增强。同时，NF-κB表达降低，而i -κB α和IL-10表达上调，显示抗炎活性。结论甜菜素与茶黄素联合应用通过促进血管生成和调节炎症反应促进体外创面愈合。这种综合策略可能为口腔和皮肤伤口的组织修复提供一种有前途的自然治疗方法。

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引用次数: 0

Prognostic significance of multinucleated giant cells in oral squamous cell carcinoma: A retrospective clinicopathological study 口腔鳞状细胞癌多核巨细胞的预后意义：回顾性临床病理研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-01 Epub Date: 2025-12-16 DOI: 10.1016/j.jobcr.2025.12.005

Kuldeep Singh, Priya Kumar, Aadithya B. Urs

Background

Multinucleated Giant Cells (MGCs) are akin to immune cells that play a crucial role in the tumor microenvironment. The present study aimed to evaluate the prognostic and clinicopathological significance of MGCs in Oral Squamous Cell Carcinoma (OSCC) through comprehensive analysis of their presence, localization, and correlation with survival outcomes.

Objective

To determine whether the presence and distribution of MGCs in OSCC correlates with tumor stage, histopathological features, and overall survival, thereby assessing their potential prognostic value.

Material and methods

100 proven cases of OSCC were retrieved with complete clinicopathological data. Haematoxylin-eosin sections were reviewed independently by three pathologists and grouped into two, with and without MGCs. The distribution, and average number of MGCs per 5HPF per case were examined. All clinicopathological parameters and prognosis based on Bryne's grading were compared between groups. The overall survival with follow-up period of >36 months was analyzed.

Results

34 cases with MGCs were found, out of which 21 patients are alive. Cases with MGCs had pTNM stage III whereas majority of cases without MGC's had stage IV. Significant correlation was found for lympho-vascular invasion only. Cases with MGC's showed good prognostic score according to Bryne's grading, while without MGC's showed moderate to poor prognostic score. Cases of alveolar mucosa, including gingiva and ridge SCC with MGCs, showed poor survival.

Conclusions

This study highlights the potential role of MGCs in OSCC, suggesting an association with earlier tumor stages and favorable prognostic scores. Further research is needed to assess their prognostic and therapeutic relevance.

多核巨细胞（MGCs）类似于免疫细胞，在肿瘤微环境中起着至关重要的作用。本研究旨在通过综合分析MGCs在口腔鳞状细胞癌（OSCC）中的存在、定位及其与生存结果的相关性，评估MGCs在口腔鳞状细胞癌（OSCC）中的预后和临床病理意义。目的探讨MGCs在OSCC中的存在及分布是否与肿瘤分期、组织病理特征及总生存期相关，从而评估其潜在的预后价值。材料与方法回顾性分析100例经证实的OSCC患者的临床病理资料。血红素-伊红切片由三名病理学家独立检查，并分为两组，有和没有MGCs。检查了每例5HPF的MGCs分布和平均数量。比较两组间所有临床病理参数及基于Bryne分级的预后。分析两组患者的总生存期，随访36个月。结果共发现MGCs 34例，存活21例。有MGC的患者有III期pTNM，而大多数没有MGC的患者有IV期pTNM。仅淋巴血管浸润有显著相关性。根据Bryne分级，有MGC的患者预后评分较好，而无MGC的患者预后评分为中至差。牙槽粘膜的病例，包括牙龈和嵴鳞状细胞癌合并MGCs，生存率较差。结论本研究强调了MGCs在OSCC中的潜在作用，提示其与早期肿瘤分期和良好预后评分相关。需要进一步的研究来评估其预后和治疗相关性。

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引用次数: 0

Development and validation of a machine learning model to predict mandibular third molar impaction and associated complications: A retrospective observational study 预测下颌第三磨牙嵌塞及相关并发症的机器学习模型的开发和验证：一项回顾性观察研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-01 Epub Date: 2025-11-14 DOI: 10.1016/j.jobcr.2025.10.026

Nancy Jidiya , Parth Rathi , Sravanthi Ennala , Anulatha Manne , C.P. Muhammed Faiz , T.H. Farzhana , Shikhar Daniel

Background

Impacted mandibular third molars are common worldwide and may cause complications such as pericoronitis, cysts, and second molar caries. Conventional prediction methods rely on subjective radiographic interpretations and clinical judgment, which can vary among practitioners. Recent advances in machine learning (ML) provide opportunities to develop objective, data-driven models for clinical decision-making in third molar management.

Aim

To develop and validate a machine learning–based model for predicting mandibular third molar impaction and associated complications using demographic and radiographic variables.

Methods

This retrospective observational study evaluated 220 panoramic radiographs of patients aged 16–40 years. Collected variables included age, sex, tooth angulation, Pell and Gregory classification, depth of impaction, root development, ramus relationship, and proximity to the mandibular canal. Logistic regression, random forest, and XGBoost were trained on 70 % of the dataset and validated on 30 %. Model performance was assessed using AUC-ROC, accuracy, sensitivity, specificity, calibration, and Cohen's Kappa for agreement with expert judgment.

Results

Impaction prevalence was 67.3 %. Significant predictors included mesioangular angulation, Pell and Gregory Class II, and incomplete root development (p < 0.001). XGBoost outperformed other models, achieving an AUC-ROC of 0.92, accuracy of 90.5 %, and Kappa of 0.82. Pericoronitis (26 %) and distal second molar caries (18 %) were the most common complications.

Conclusion

XGBoost demonstrated high predictive accuracy for mandibular third molar impaction and complications. As a probability-based decision-support tool, it can provide individualized risk estimates or binary classifications to assist clinicians in counseling, surveillance, and surgical decision-making.

背景：下颌第三磨牙的磨蚀在世界范围内是很常见的，并且可能引起诸如冠周炎、囊肿和第二磨牙龋齿等并发症。传统的预测方法依赖于主观的放射学解释和临床判断，这可能因从业者而异。机器学习（ML）的最新进展为第三磨牙管理的临床决策提供了开发客观、数据驱动模型的机会。目的开发并验证基于机器学习的模型，利用人口统计学和放射学变量预测下颌第三磨牙嵌塞和相关并发症。方法回顾性观察220例16 ~ 40岁患者的全景x线片。收集的变量包括年龄、性别、牙齿角度、Pell和Gregory分类、嵌塞深度、牙根发育、支的关系以及与下颌管的接近程度。逻辑回归、随机森林和XGBoost在70%的数据集上进行训练，并在30%的数据集上进行验证。采用AUC-ROC、准确性、敏感性、特异性、校准和Cohen’s Kappa来评估模型的性能是否与专家判断一致。结果压实率为67.3%。显著的预测因子包括中角角度、Pell和Gregory II类和不完全根发育（p < 0.001）。XGBoost优于其他模型，AUC-ROC为0.92，准确率为90.5%，Kappa为0.82。冠周炎（26%）和远端第二磨牙龋（18%）是最常见的并发症。结论xgboost对下颌第三磨牙嵌塞及其并发症具有较高的预测准确性。作为一种基于概率的决策支持工具，它可以提供个性化的风险估计或二元分类，以协助临床医生进行咨询、监测和手术决策。

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引用次数: 0

Evaluation of postoperative pain in patients using 8.25 % sodium hypochlorite compared with 5.25 % sodium hypochlorite using sonic and ultrasonic activation methods after single visit root canal treatment: an in-vivo study 使用8.25%次氯酸钠与使用5.25%次氯酸钠超声和超声激活法进行单次根管治疗后患者术后疼痛的评估：一项体内研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2026-01-01 Epub Date: 2025-11-15 DOI: 10.1016/j.jobcr.2025.11.004

Kabir Bulchandani, Shahina Parvez, Lalit Kumar Likhyani, Manoj Kumar Agarwal, Rohit Kumar Khatri, Deepak Goel

Introduction

The aim of this study was to evaluate the postoperative pain in patients using 8.25 % sodium hypochlorite compared to 5.25 % Sodium Hypochlorite concentration without activation and using sonic and ultrasonic activation methods after single visit root canal treatment.

Methods

In this double blind randomized trial, a total of 120 participants mandibular premolar with symptomatic irreversible pulpitis were included and randomly divided into 6 groups based on the different concentration of sodium hypochlorite and activation methods (sonic & ultrasonic activation) i.e. Group 1: 5.25 % NaOCl with no activation method, Group 2: 8.25 % NaOCl with no activation method, Group 3: 5.25 % NaOCl with sonic activation, Group 4: 5.25 % NaOCl with Ultrasonic activation, Group 5: 8.25 % NaOCl with sonic activation, Group 6: 8.25 % NaOCl with ultrasonic activation. The presence of postoperative pain was assessed 24, 48, and 72 h after treatment and recorded using the visual analogue scale (VAS).

Results

Intragroup postoperative pain in all six groups reduced after 24 h, 48 h and 72 h, showing statistically significant differences. At all-time intervals, postoperative pain was higher in the groups that used ultrasonic stimulation.

Conclusion

At all-time intervals, there was no significant difference in the presence of postoperative pain between the 8.25 % NaOCl and 5.25 % NaOCl irrigation solutions with no activation method and sonic activation compared to ultrasonic activation.

本研究的目的是评价使用8.25%次氯酸钠与使用5.25%次氯酸钠无激活、超声和超声激活方法的患者在单次根管治疗后的术后疼痛。方法采用双盲随机试验方法，选取120例有症状的不可逆性牙髓炎的下颌前磨牙患者，根据次氯酸钠浓度和激活方式（超声和超声激活）的不同，随机分为6组：1组：5.25% NaOCl无激活，2组：8.25% NaOCl无激活，3组：5.25% NaOCl有声音激活，4组：5.25% NaOCl有声音激活。5.25% NaOCl超声活化，第5组：8.25% NaOCl超声活化，第6组：8.25% NaOCl超声活化。分别在治疗后24、48、72 h评估患者的术后疼痛情况，并采用视觉模拟评分（VAS）进行记录。结果各组术后24 h、48 h、72 h疼痛均减轻，差异有统计学意义。在所有时间间隔内，使用超声刺激组的术后疼痛更高。结论8.25% NaOCl冲洗液与5.25% NaOCl冲洗液无激活、超声激活与超声激活在术后疼痛发生率上无显著性差异。

{"title":"Evaluation of postoperative pain in patients using 8.25 % sodium hypochlorite compared with 5.25 % sodium hypochlorite using sonic and ultrasonic activation methods after single visit root canal treatment: an in-vivo study","authors":"Kabir Bulchandani, Shahina Parvez, Lalit Kumar Likhyani, Manoj Kumar Agarwal, Rohit Kumar Khatri, Deepak Goel","doi":"10.1016/j.jobcr.2025.11.004","DOIUrl":"10.1016/j.jobcr.2025.11.004","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to evaluate the postoperative pain in patients using 8.25 % sodium hypochlorite compared to 5.25 % Sodium Hypochlorite concentration without activation and using sonic and ultrasonic activation methods after single visit root canal treatment.</div></div><div><h3>Methods</h3><div>In this double blind randomized trial, a total of 120 participants mandibular premolar with symptomatic irreversible pulpitis were included and randomly divided into 6 groups based on the different concentration of sodium hypochlorite and activation methods (sonic & ultrasonic activation) i.e. Group 1: 5.25 % NaOCl with no activation method, Group 2: 8.25 % NaOCl with no activation method, Group 3: 5.25 % NaOCl with sonic activation, Group 4: 5.25 % NaOCl with Ultrasonic activation, Group 5: 8.25 % NaOCl with sonic activation, Group 6: 8.25 % NaOCl with ultrasonic activation. The presence of postoperative pain was assessed 24, 48, and 72 h after treatment and recorded using the visual analogue scale (VAS).</div></div><div><h3>Results</h3><div>Intragroup postoperative pain in all six groups reduced after 24 h, 48 h and 72 h, showing statistically significant differences. At all-time intervals, postoperative pain was higher in the groups that used ultrasonic stimulation.</div></div><div><h3>Conclusion</h3><div>At all-time intervals, there was no significant difference in the presence of postoperative pain between the 8.25 % NaOCl and 5.25 % NaOCl irrigation solutions with no activation method and sonic activation compared to ultrasonic activation.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"16 1","pages":"Pages 101-105"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145527677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0