Journal of oral biology and craniofacial research最新文献

A hybrid neoplasm is the coexistence of two histologically distinct neoplasms which arise in the same topographical area resulting in a single common mass. A seventy-one-year-old female presented with a complaint of loss of vision and pain in her right eye for a period of five months. On clinical-radiological investigations, a single ovoid,non-fluctuant, firm, tender swelling was present on the right supraorbital region with mild proptosis and redness of the right eye. Magnetic resonance imaging showed a well-defined, lobulated heterogeneously enhancing lesion on the superolateral part of the right orbit suggestive of lacrimal gland neoplasm. The specimen was submitted after wide excision with orbital exenteration and ipsilateral radical neck dissection. Histopathological evaluation revealed two different morphologic patterns of infiltrating islands of epithelial cells suggestive of an adenocarcinoma and squamous carcinoma. Histopathology with additional immunohistochemical workup concluded the lesion to be a Hybrid neoplasm of the Lacrimal gland; Adenocarcinoma NOS with Primary squamous cell carcinoma. Hybrid neoplasm of the head and neck region is found to be common in salivary glands while its occurrence in the lacrimal gland is very rare in literature.

Background: Tetric N-Ceram, recently introduced as an alternative to bulk-fill flowable and traditional non-flowable composite. Cention N, recently introduced tooth-coloured filling material for bulk placement in retentive preparations.

Aim: The aim of the present study is to evaluate the performance of Tetric N Ceram and Cention N as restorative materials in Class 1 carious lesions in primary mandibular molars.

Design: A prospective double-blind, split-mouth, parallel-group, randomized study was conducted on 34 patients having bilateral Class I carious lesions on mandibular primary molars. 68 teeth were divided into 2 groups: Group 1 was treated with Cention N and Group 2 with Tetric N Ceram. All restorations were clinically evaluated at Baseline - 24hrs, 3, 6 and 9 months for marginal integrity (MI), secondary caries(SC) and gross fracture(GF) using the US Public Health Service criteria (modified Ryge criteria). For post-operative sensitivity(POS), Wong Bakers faces pain rating scale was used.

Results: Intragroup comparison of MI, SC and GF in Group 1 and group 2 showed non-significant difference at all-time intervals. Intergroup comparison showed non-significant difference for MI, SC, GF and POS at all-time intervals.

Conclusion: Tetric N Ceram and Cention N in terms of MI, SC, GF and POS provide similar results.

Introduction: Dynamic navigation (DN), a computer-assisted technique integrating CBCT data and real-time video, has emerged as a promising approach to place implants in the recent years. This study aims to evaluate the consistency and ease of use of a dynamic navigation system for implant placement by comparing the accuracy in single and adjacent implant placements and workability achieved by three different operators.

Methods: This study included Forty-eight patients requiring dental implants, total of sixty implants were randomly assigned to 3 operators of varying experiences, the implants were planned and placed under DN. The accuracy of implant placement were measured in terms of mesio-distal, apico-coronal displacement and angulations using Evalunav application (Navident, Claronav, Canada). Secondary outcome variables are the number of errors encountered during the procedure and the time taken for the procedure by different practitioners. Kruskal Wallis Test followed by the Post hoc Mann Whitney U test. The level of significance was set at P < 0.05.

Results: There were no significant differences in the accuracy of single implants (P > 0.05). For adjacent implants (T1), the displacement in mesiodistal direction was significantly different (P = 0.003) and also for apico-coronal position of T1-abutment group when compared to controls with a P value of 0.026. Experienced surgeons had the highest error rates as well and longest time (18.27 ± 5.62 versus 15 min).

Conclusions: The operating surgeon do not determine the accuracy rather the navigation system comes with a steep learning curve that needs to be acquired prior to practicing the same.

Background: Acrylic resins are extensively used in prosthodontics, orthodontics and maxillofacial prosthetics due to their ease of fabrication and cost-effectiveness. However, conventional acrylic materials are susceptible to microbial colonization, mechanical deterioration and esthetic compromise. To overcome these limitations, recent research has explored the incorporation of nanoparticles into polymethyl methacrylate (PMMA)-based resins to enhance their antimicrobial efficacy, mechanical strength, biocompatibility, and long-term durability.

Methods: This systematic review was conducted according to PRISMA guidelines. An extensive literature search was performed across PubMed/MEDLINE, Scopus, Web of Science, Cochrane Library and Embase for studies published up to January 18, 2025. Only in vivo studies conducted on humans or animals evaluating nanoparticle-coated or nanoparticle-impregnated acrylic resins were included. Standalone in vitro studies were excluded. Risk of bias was assessed using Cochrane's RoB 2.0 tool for randomized controlled trials (RCTs), ROBINS-I for non-randomized studies and the SYRCLE tool for animal studies.

Results: Out of 3154 records initially identified, six studies met the eligibility criteria. The nanoparticles incorporated included silver, titanium dioxide, nanocopper, nanogold and quaternary ammonium polyethyleneimine (QPEI). All included studies reported antimicrobial activity with nanogold, nanocopper and QPEI showing sustained microbial inhibition. Mechanical outcomes varied: silver and titanium dioxide nanoparticles were associated with reduced material strength, whereas nanocopper maintained mechanical performance. Esthetic outcomes indicated that silver-based modifications caused discoloration, while nanocopper and QPEI preserved color stability.

Conclusion: Nanoparticle-modified acrylic resins exhibit enhanced antimicrobial and biocompatibility profiles with certain formulations particularly those incorporating nanocopper, nanogold and QPEI showing greater clinical potential. However, mechanical durability and esthetic alterations remain challenges especially with silver and titanium-based additives. Further well-designed, long-term randomized controlled trials are warranted to validate the clinical applicability of these nano-enhanced acrylic materials.

Purpose: This ex vivo study aims to evaluate and compare the fluoride-releasing capabilities of different modifications of Glass ionomer cement, namely Giomer, Zirconomer, and Pediatric GIC (type IX) with Resin-modified Glass ionomer cement (RMGIC) in the primary dentition at first, fourteenth, and twenty-eighth days.

Materials and methods: Fifty-six extracted human primary molars were allocated into four groups: Group 1, Resin-modified GIC; Group 2, Giomer; Group 3, Zirconomer; and Group 4, Pediatric GIC (type IX). The tooth samples (n = 14) were restored as per the manufacturer's instructions after making class II cavities in primary molars. Extracted tooth specimens were placed in deionized water, and the fluoride ions released were measured for 28 days. The tooth samples were evaluated for cumulative fluoride levels at the end of 24 h, 14th day, and 28th day under normal atmospheric conditions, using a fluoride ion-selective electrode (Orion STAR-A214 Ion analyzer). The data obtained was subjected to statistical analysis, and the results are discussed herein.

Results: Fluoride ions releasing capability was exhibited by primary teeth restored with all the above-mentioned materials. The primary teeth restored with Zirconomer exhibited significantly higher fluoride-releasing capability among the above-compared materials, and the primary teeth restored with Giomer exhibited the least fluoride ions release on 24 h, 14th day, and 28th day, and the difference of fluoride ions releasing ability between the four groups was statistically significant at each time interval (P < 0.001).

Conclusion: The primary teeth restored with Zirconomer exhibited superior fluoride-releasing ability compared to other restorative materials. Therefore, Zirconomer can be a promising restorative material for primary teeth due to its enhanced anti-caries effect.

Background: Dental caries is a widespread non-communicable disease caused by interactions among acidogenic bacteria, fermentable carbohydrates, and host factors, leading to tooth demineralization. In dentin caries, this process exposes dentinal tubules, causing sensitivity and structural degradation. Despite available agents, effective dentin remineralization remains a challenge. Recent studies highlight samarium-doped hydroxyapatite (Sm-HAp) as a potential biomaterial for promoting remineralization.

Aim: To synthesize and characterize the samarium doped hydroxyapatite (Sm-HAp) as a potential agent in dentin remineralization.

Materials and methods: Sm-HAp was synthesized via wet-chemical precipitation. Characterization was performed using SEM for morphology, FTIR for functional groups, and XRD for crystalline features. MTT assay evaluated for biocompatibility and in vitro mineralization analyzed on human tooth samples.

Results: SEM showed flake-like, and needle-shaped crystals. XRD indicated the formation Sm doped hydroxyapatite without any additional phase, which further confirmed by FTIR. MTT assay showed >85 % cell viability, confirming high biocompatibility and also an efficient dentine mineralization was observed with Sm-HAp treatment.

Conclusion: Sm-HAp demonstrates favorable structural, chemical, and biological properties, supporting its potential as a dentin remineralizing agent in dental caries management.