Journal of oral biology and craniofacial research最新文献

Introduction: and aim: Due to its excellent mechanical strength and biocompatibility, Polyetherketoneketone (PEKK) is emerging as a potential substitute for titanium in dental implant applications. The aim of the study was to evaluate its cytotoxicity, pro-inflammatory responses, and molecular interactions to assess its potential in implant applications.

Methods: This study evaluated the cytotoxicity, pro-inflammatory cytokine responses, and molecular interactions of PEKK compared to titanium. Disc-shaped samples (10 mm × 2 mm) were fabricated for each material following ISO standards. Human periodontal fibroblast cells were cultured and treated with the samples for cytotoxicity assessment using the MTT assay, while pro-inflammatory cytokine gene expression (IL-1β, TNF-α) was analyzed via real-time PCR. Molecular docking was conducted using AutoDock to investigate PEKK's binding interactions with cytokines, and data was analyzed with one-way ANOVA and post hoc test (P < 0.05).

Results: PEKK showed comparable cytocompatibility to titanium, yielding similar outcomes in cell viability (P > 0.05) or pro-inflammatory cytokine expression (P > 0.05). Molecular docking revealed strong interactions with IL-1β (-8.9 kcal/mol) and TNF-α (-7.3 kcal/mol).

Conclusion: This study demonstrates that PEKK exhibits comparable cytocompatibility and pro-inflammatory responses to titanium, with a potential to modulate inflammatory pathways. Further in vivo studies are needed to confirm its clinical viability as an implant material.

Clinical relevance: This study gives the clue of PEKK as an aesthetic implant biomaterial and it can be useful as an alternative to Titanium dental implant.

A hybrid neoplasm is the coexistence of two histologically distinct neoplasms which arise in the same topographical area resulting in a single common mass. A seventy-one-year-old female presented with a complaint of loss of vision and pain in her right eye for a period of five months. On clinical-radiological investigations, a single ovoid,non-fluctuant, firm, tender swelling was present on the right supraorbital region with mild proptosis and redness of the right eye. Magnetic resonance imaging showed a well-defined, lobulated heterogeneously enhancing lesion on the superolateral part of the right orbit suggestive of lacrimal gland neoplasm. The specimen was submitted after wide excision with orbital exenteration and ipsilateral radical neck dissection. Histopathological evaluation revealed two different morphologic patterns of infiltrating islands of epithelial cells suggestive of an adenocarcinoma and squamous carcinoma. Histopathology with additional immunohistochemical workup concluded the lesion to be a Hybrid neoplasm of the Lacrimal gland; Adenocarcinoma NOS with Primary squamous cell carcinoma. Hybrid neoplasm of the head and neck region is found to be common in salivary glands while its occurrence in the lacrimal gland is very rare in literature.

Background: Tetric N-Ceram, recently introduced as an alternative to bulk-fill flowable and traditional non-flowable composite. Cention N, recently introduced tooth-coloured filling material for bulk placement in retentive preparations.

Aim: The aim of the present study is to evaluate the performance of Tetric N Ceram and Cention N as restorative materials in Class 1 carious lesions in primary mandibular molars.

Design: A prospective double-blind, split-mouth, parallel-group, randomized study was conducted on 34 patients having bilateral Class I carious lesions on mandibular primary molars. 68 teeth were divided into 2 groups: Group 1 was treated with Cention N and Group 2 with Tetric N Ceram. All restorations were clinically evaluated at Baseline - 24hrs, 3, 6 and 9 months for marginal integrity (MI), secondary caries(SC) and gross fracture(GF) using the US Public Health Service criteria (modified Ryge criteria). For post-operative sensitivity(POS), Wong Bakers faces pain rating scale was used.

Results: Intragroup comparison of MI, SC and GF in Group 1 and group 2 showed non-significant difference at all-time intervals. Intergroup comparison showed non-significant difference for MI, SC, GF and POS at all-time intervals.

Conclusion: Tetric N Ceram and Cention N in terms of MI, SC, GF and POS provide similar results.

Introduction: Dynamic navigation (DN), a computer-assisted technique integrating CBCT data and real-time video, has emerged as a promising approach to place implants in the recent years. This study aims to evaluate the consistency and ease of use of a dynamic navigation system for implant placement by comparing the accuracy in single and adjacent implant placements and workability achieved by three different operators.

Methods: This study included Forty-eight patients requiring dental implants, total of sixty implants were randomly assigned to 3 operators of varying experiences, the implants were planned and placed under DN. The accuracy of implant placement were measured in terms of mesio-distal, apico-coronal displacement and angulations using Evalunav application (Navident, Claronav, Canada). Secondary outcome variables are the number of errors encountered during the procedure and the time taken for the procedure by different practitioners. Kruskal Wallis Test followed by the Post hoc Mann Whitney U test. The level of significance was set at P < 0.05.

Results: There were no significant differences in the accuracy of single implants (P > 0.05). For adjacent implants (T1), the displacement in mesiodistal direction was significantly different (P = 0.003) and also for apico-coronal position of T1-abutment group when compared to controls with a P value of 0.026. Experienced surgeons had the highest error rates as well and longest time (18.27 ± 5.62 versus 15 min).

Conclusions: The operating surgeon do not determine the accuracy rather the navigation system comes with a steep learning curve that needs to be acquired prior to practicing the same.

Background: Acrylic resins are extensively used in prosthodontics, orthodontics and maxillofacial prosthetics due to their ease of fabrication and cost-effectiveness. However, conventional acrylic materials are susceptible to microbial colonization, mechanical deterioration and esthetic compromise. To overcome these limitations, recent research has explored the incorporation of nanoparticles into polymethyl methacrylate (PMMA)-based resins to enhance their antimicrobial efficacy, mechanical strength, biocompatibility, and long-term durability.

Methods: This systematic review was conducted according to PRISMA guidelines. An extensive literature search was performed across PubMed/MEDLINE, Scopus, Web of Science, Cochrane Library and Embase for studies published up to January 18, 2025. Only in vivo studies conducted on humans or animals evaluating nanoparticle-coated or nanoparticle-impregnated acrylic resins were included. Standalone in vitro studies were excluded. Risk of bias was assessed using Cochrane's RoB 2.0 tool for randomized controlled trials (RCTs), ROBINS-I for non-randomized studies and the SYRCLE tool for animal studies.

Results: Out of 3154 records initially identified, six studies met the eligibility criteria. The nanoparticles incorporated included silver, titanium dioxide, nanocopper, nanogold and quaternary ammonium polyethyleneimine (QPEI). All included studies reported antimicrobial activity with nanogold, nanocopper and QPEI showing sustained microbial inhibition. Mechanical outcomes varied: silver and titanium dioxide nanoparticles were associated with reduced material strength, whereas nanocopper maintained mechanical performance. Esthetic outcomes indicated that silver-based modifications caused discoloration, while nanocopper and QPEI preserved color stability.

Conclusion: Nanoparticle-modified acrylic resins exhibit enhanced antimicrobial and biocompatibility profiles with certain formulations particularly those incorporating nanocopper, nanogold and QPEI showing greater clinical potential. However, mechanical durability and esthetic alterations remain challenges especially with silver and titanium-based additives. Further well-designed, long-term randomized controlled trials are warranted to validate the clinical applicability of these nano-enhanced acrylic materials.