Journal of oral biology and craniofacial research最新文献_第7页

Illness perception in patients with dental caries: A co-relational study in Odisha

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2025.01.003

Hemamalini Rath, Abhijit Panda, Shilpa Mahapatra

Background

Illness behaviour refers to any actions or reactions of an individual who feels unwell for defining their state of health and obtaining physical or emotional relief from perceived or actual illness. The present study was conducted to assess illness perception of patients having dental caries using Illness Perceptions Questionnaire-Revised (IPQ-R) in Odisha.

Materials and methods

A descriptive co-relational study was conducted among 250 patients with self-reported dental caries in at least one tooth and more than 18 years of age. Data was collected using a cross-culturallyvalidated IPQ-R tool. This was followed by assessment for dental caries using Caries Severity Index. Spearman's correlation and multivariable analysis were conducted.

Results

Toothache, visible hole, tooth sensitivity, pain during taking hot and cold food were perceived to be associated with dental caries. Nearly half of the patients had a caries severity score of 5 (pulpitis) or more. Majority (83 %) of participants reported presence of a “visible hole” when they had dental caries. Caries severity was positively correlated with timeline acute/chronic, timeline cyclical and consequence. Significant correlations were noted between IPQ-R components as well.

Conclusion

Dental caries was mostly considered to be acute in nature. The study subjects perceived dental caries to have serious consequence, emotionally disturbing symptoms, which they could control by seeking treatment. Further studies need to be conductedwith a larger sample size.

{"title":"Illness perception in patients with dental caries: A co-relational study in Odisha","authors":"Hemamalini Rath, Abhijit Panda, Shilpa Mahapatra","doi":"10.1016/j.jobcr.2025.01.003","DOIUrl":"10.1016/j.jobcr.2025.01.003","url":null,"abstract":"<div><h3>Background</h3><div>Illness behaviour refers to any actions or reactions of an individual who feels unwell for defining their state of health and obtaining physical or emotional relief from perceived or actual illness. The present study was conducted to assess illness perception of patients having dental caries using Illness Perceptions Questionnaire-Revised (IPQ-R) in Odisha.</div></div><div><h3>Materials and methods</h3><div>A descriptive co-relational study was conducted among 250 patients with self-reported dental caries in at least one tooth and more than 18 years of age. Data was collected using a cross-culturallyvalidated IPQ-R tool. This was followed by assessment for dental caries using Caries Severity Index. Spearman's correlation and multivariable analysis were conducted.</div></div><div><h3>Results</h3><div>Toothache, visible hole, tooth sensitivity, pain during taking hot and cold food were perceived to be associated with dental caries. Nearly half of the patients had a caries severity score of 5 (pulpitis) or more. Majority (83 %) of participants reported presence of a “visible hole” when they had dental caries. Caries severity was positively correlated with timeline acute/chronic, timeline cyclical and consequence. Significant correlations were noted between IPQ-R components as well.</div></div><div><h3>Conclusion</h3><div>Dental caries was mostly considered to be acute in nature. The study subjects perceived dental caries to have serious consequence, emotionally disturbing symptoms, which they could control by seeking treatment. Further studies need to be conductedwith a larger sample size.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 136-140"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis and systematic review for the genetic basis of cleft lip and palate

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2025-01-01 DOI: 10.1016/j.jobcr.2024.12.012

Wafaa Yahia Alghonemy , Mohamed Gaber Ashmawy

Cleft lip and palate (CLP) are a usually inherited anomaly described as a gap in the oral cavity's upper lip and/or roof. The etiology of CLP involves both genetic and environmental factors. The current study aimed to examine the genetic basis of nonsyndromic (NS) CLP (NSCL/P) and its association with specific genetic polymorphisms. We conducted a meta-analysis and systematic review of seven articles, which provided information on the correlation between genes and NSCL/P risk.

Our results proved that the MTHFR c.677C > T polymorphism was correlated with the risk of NSCL/P, favoring the control group in the CC genotype and the cases group in the CT genotype. The TT genotype favored the control group. Additionally, the MTHFD1 1958G > A polymorphism was correlated with the high NSCL/P risk in children. However, the MTHFR C677T polymorphism did not show a significant correlation with NSCL/P risk in the analysis, although it was correlated with the high risk in specific populations.

These results contribute to our knowledge about the genetic causes of NSCL/P and highlight the importance of specific genetic polymorphisms in its development. Further research is needed to explore the genetic mechanisms underlying NSCL/P in different populations and to elucidate its implications for diagnosis, treatment, and prevention strategies.

{"title":"Meta-analysis and systematic review for the genetic basis of cleft lip and palate","authors":"Wafaa Yahia Alghonemy , Mohamed Gaber Ashmawy","doi":"10.1016/j.jobcr.2024.12.012","DOIUrl":"10.1016/j.jobcr.2024.12.012","url":null,"abstract":"<div><div>Cleft lip and palate (CLP) are a usually inherited anomaly described as a gap in the oral cavity's upper lip and/or roof. The etiology of CLP involves both genetic and environmental factors. The current study aimed to examine the genetic basis of nonsyndromic (NS) CLP (NSCL/P) and its association with specific genetic polymorphisms. We conducted a meta-analysis and systematic review of seven articles, which provided information on the correlation between genes and NSCL/P risk.</div><div>Our results proved that the MTHFR c.677C > T polymorphism was correlated with the risk of NSCL/P, favoring the control group in the CC genotype and the cases group in the CT genotype. The TT genotype favored the control group. Additionally, the MTHFD1 1958G > A polymorphism was correlated with the high NSCL/P risk in children. However, the MTHFR C677T polymorphism did not show a significant correlation with NSCL/P risk in the analysis, although it was correlated with the high risk in specific populations.</div><div>These results contribute to our knowledge about the genetic causes of NSCL/P and highlight the importance of specific genetic polymorphisms in its development. Further research is needed to explore the genetic mechanisms underlying NSCL/P in different populations and to elucidate its implications for diagnosis, treatment, and prevention strategies.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 146-152"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial flora surrounding orthodontic temporary skeletal anchorage devices: A systematic review 正畸临时骨骼锚定装置周围的微生物菌群：系统综述

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-12-01 DOI: 10.1016/j.jobcr.2024.11.005

Navia Jose Paul, Haritha Pottipalli Sathyanarayana, Vignesh Kailasam

Aim

The oral cavity harbours distinct microorganisms, which create a unique microenvironment. These microorganisms might trigger inflammatory reactions in the host, potentially leading to inflammation that can question the stability of temporary skeletal anchorage devices(TSADs). This study aimed to systematically review the literature on the type of microorganisms around TSADs.

Methods

A search of studies in six electronic databases – Cochrane Library, PubMed, OVID, Scopus, LILACS and Web of Science were performed until 30 May 2024 without any restriction in date or language of publication. The selection of articles was limited to studies evaluating the microorganisms around TSADs during orthodontic treatment. Two reviewers independently performed eligibility screening, study selection, and data extraction. The Newcastle Ottawa scale was used to assess the Risk of bias in all the included studies. Meta-analysis could not be performed because of the heterogeneity of the studies.

Results

From 7020 articles, seven prospective studies were included for the qualitative analysis. Porphyromonas gingivalis and Treponema denticola were found around all TSADs used in orthodontic therapy. There was a significant difference in the type of microorganisms around successful and failed TSADs.

Conclusions

There was an overall colonization of diverse microorganisms around TSADS. Failed TSADs showed greater Porphyromonas gingivalis, Parvimonas micra and facultative anaerobic enteric commensal Enterobacter.

目的口腔内有独特的微生物，形成独特的微环境。这些微生物可能会引发宿主的炎症反应，潜在地导致炎症，从而质疑临时骨骼锚固装置（TSADs）的稳定性。本研究旨在系统地综述有关TSADs周围微生物类型的文献。方法检索Cochrane Library、PubMed、OVID、Scopus、LILACS和Web of Science 6个电子数据库的研究，截止到2024年5月30日，不受发表日期和语言的限制。文章的选择仅限于评估正畸治疗期间TSADs周围微生物的研究。两名审稿人独立进行资格筛选、研究选择和数据提取。纽卡斯尔渥太华量表用于评估所有纳入研究的偏倚风险。由于研究的异质性，不能进行meta分析。结果从7020篇文献中纳入7项前瞻性研究进行定性分析。在正畸治疗中发现牙龈卟啉单胞菌和牙密螺旋体。成功和失败的TSADs周围的微生物类型有显著差异。结论TSADS周围有多种微生物的定殖。失败的TSADs显示较多的牙龈卟啉单胞菌、微细小单胞菌和兼性厌氧肠道共生肠杆菌。

{"title":"Microbial flora surrounding orthodontic temporary skeletal anchorage devices: A systematic review","authors":"Navia Jose Paul, Haritha Pottipalli Sathyanarayana, Vignesh Kailasam","doi":"10.1016/j.jobcr.2024.11.005","DOIUrl":"10.1016/j.jobcr.2024.11.005","url":null,"abstract":"<div><h3>Aim</h3><div>The oral cavity harbours distinct microorganisms, which create a unique microenvironment. These microorganisms might trigger inflammatory reactions in the host, potentially leading to inflammation that can question the stability of temporary skeletal anchorage devices(TSADs). This study aimed to systematically review the literature on the type of microorganisms around TSADs.</div></div><div><h3>Methods</h3><div>A search of studies in six electronic databases – Cochrane Library, PubMed, OVID, Scopus, LILACS and Web of Science were performed until 30 May 2024 without any restriction in date or language of publication. The selection of articles was limited to studies evaluating the microorganisms around TSADs during orthodontic treatment. Two reviewers independently performed eligibility screening, study selection, and data extraction. The Newcastle Ottawa scale was used to assess the Risk of bias in all the included studies. Meta-analysis could not be performed because of the heterogeneity of the studies.</div></div><div><h3>Results</h3><div>From 7020 articles, seven prospective studies were included for the qualitative analysis. Porphyromonas gingivalis and Treponema denticola were found around all TSADs used in orthodontic therapy. There was a significant difference in the type of microorganisms around successful and failed TSADs.</div></div><div><h3>Conclusions</h3><div>There was an overall colonization of diverse microorganisms around TSADS. Failed TSADs showed greater Porphyromonas gingivalis, Parvimonas micra and facultative anaerobic enteric commensal Enterobacter.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 25-32"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An unusual surgical complication: Slipped molar lodged in vocal cords and its anesthetic management 一个不寻常的手术并发症：臼齿滑进声带及其麻醉处理

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-30 DOI: 10.1016/j.jobcr.2024.11.006

Ameerunnisha begum , Ramsesh Manohar Ram , Monisha Prasad

Background

Extraction of wisdom tooth is one of the most common surgical interventions, as it is more prone for impaction. Due to the pain and anxiety associated with the procedure, it is common to do this procedure under conscious sedation. However unexpected events do occur during the procedure and one such complication along with the prompt management is discussed here.

Case report

This case report details an unusual occurrence of a third molar tooth slipping during dental extraction and becoming lodged at the base of the vocal cords. The patient, a 52-year-old man with a history of hypertension, underwent the procedure under conscious sedation. The case report highlights the importance of preparedness and multidisciplinary coordination in managing rare complications during dental procedures under conscious sedation. The accidental aspiration of a molar tooth into the airway required prompt and effective intervention, using dexmedetomidine for sedation, fibre-optic bronchoscopy for visualization, and a range of retrieval instruments. Using video-assisted laryngoscopy and fibre-optic laryngoscopy proved indispensable in locating and safely retrieving the foreign body without resorting to more invasive procedures.

Conclusion

This case highlights the importance of anaesthesiologist's role in emergency management and comprehensive preparedness in dental practice.

摘出智齿是最常见的外科手术之一，因为它更容易发生嵌塞。由于与手术相关的疼痛和焦虑，通常在清醒镇静下进行该手术。然而，在手术过程中确实会发生意想不到的事件，这里讨论的是一种伴随及时处理的并发症。本病例报告详细描述了一个不寻常的第三磨牙在拔牙时滑落并卡在声带底部的情况。患者是一名52岁的男性，有高血压病史，在清醒镇静下接受了手术。病例报告强调了准备和多学科协调的重要性，以管理罕见的并发症在牙科手术在清醒镇静。意外误吸磨牙进入气道需要及时有效的干预，使用右美托咪定镇静，纤维支气管镜观察，以及一系列回收工具。使用视频辅助喉镜和纤维喉镜被证明是在定位和安全取出异物时必不可少的，而不需要更多的侵入性手术。结论本病例强调了麻醉师在牙科急诊管理和全面准备中的重要性。

{"title":"An unusual surgical complication: Slipped molar lodged in vocal cords and its anesthetic management","authors":"Ameerunnisha begum , Ramsesh Manohar Ram , Monisha Prasad","doi":"10.1016/j.jobcr.2024.11.006","DOIUrl":"10.1016/j.jobcr.2024.11.006","url":null,"abstract":"<div><h3>Background</h3><div>Extraction of wisdom tooth is one of the most common surgical interventions, as it is more prone for impaction. Due to the pain and anxiety associated with the procedure, it is common to do this procedure under conscious sedation. However unexpected events do occur during the procedure and one such complication along with the prompt management is discussed here.</div></div><div><h3>Case report</h3><div>This case report details an unusual occurrence of a third molar tooth slipping during dental extraction and becoming lodged at the base of the vocal cords. The patient, a 52-year-old man with a history of hypertension, underwent the procedure under conscious sedation. The case report highlights the importance of preparedness and multidisciplinary coordination in managing rare complications during dental procedures under conscious sedation. The accidental aspiration of a molar tooth into the airway required prompt and effective intervention, using dexmedetomidine for sedation, fibre-optic bronchoscopy for visualization, and a range of retrieval instruments. Using video-assisted laryngoscopy and fibre-optic laryngoscopy proved indispensable in locating and safely retrieving the foreign body without resorting to more invasive procedures.</div></div><div><h3>Conclusion</h3><div>This case highlights the importance of anaesthesiologist's role in emergency management and comprehensive preparedness in dental practice.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 22-24"},"PeriodicalIF":0.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Umbilical cord mesenchymal stem cells improve bone regeneration in diabetes mellitus animal model with apical periodontitis 脐带间充质干细胞促进糖尿病根尖牙周炎动物模型骨再生

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-29 DOI: 10.1016/j.jobcr.2024.11.009

Eric Priyo Prasetyo , Pravinna Saravanan , Deaniddo Kharisna , Christina Immee Wijanarko , Mefina Kuntjoro , Nike Hendrijantini , Evelyn Tjendronegoro

Background

Previous studies revealed diabetes mellitus subjects tend to have persistent apical periodontitis. Regenerative stem cells therapy through endodontic procedure is hoped to be a solution. This study assessed bone regeneration in diabetic rats with apical periodontitis through histopathological analysis of osteoblasts and immunohistochemical analysis of runt-related transcription factor 2 (Runx2) and Osterix.

Methods

Diabetes mellitus and apical periodontitis was induced on 20 rats. Apical periodontitis was induced on mandibular right first molars under anesthesia. The teeth were left open for 7 days following access cavity and pulp extirpation, then the rats’ teeth were endodontically treated and randomly allocated into 4 groups (5 rats per group). The first and second groups was ended at 30 days (C30) and 60 days (C60) and labelled as control. The third and fourth groups was given umbilical cord mesenchymal stem cells and ended at 30 days (T30) and 60 days (T60). The osteoblasts, Runx2 and Osterix were analyzed. ANOVA and Tukey HSD tests were used for analysis. Differences with p values < 0.05 were considered significant.

Results

The number of osteoblasts in the apical area in control groups (C30 and C60) and treatment groups (T30 and T60) showed a significant increase (p < 0.05). The expressions of Runx2 and Osterix in osteoblasts showed a significant increase among the control (C30 and C60) and treatment groups (T30 and T60) (p < 0.05).

Conclusion

Umbilical cord mesenchymal stem cells improve bone regeneration in diabetic animal model with apical periodontitis, in terms of osteoblasts, Runx2 and Osterix.

背景以往的研究显示糖尿病患者有持续性根尖牙周炎的倾向。通过牙髓治疗再生干细胞有望成为一种解决方案。本研究通过成骨细胞的组织病理学分析和runt相关转录因子2 （Runx2）和Osterix的免疫组化分析来评估糖尿病大鼠根尖牙周炎的骨再生。方法对20只大鼠进行糖尿病和根尖牙周炎诱导实验。麻醉下右下颌第一磨牙诱发根尖牙周炎。拔牙后开放7 d，进行根管治疗，随机分为4组（每组5只）。第一组和第二组分别于第30天（C30）和第60天（C60）结束，作为对照组。第三组和第四组给予脐带间充质干细胞，分别于30天（T30）和60天（T60）结束治疗。对成骨细胞、Runx2、Osterix进行分析。采用方差分析和Tukey HSD检验进行分析。p值的差异<；0.05为显著性。结果对照组（C30、C60）和治疗组（T30、T60）根尖区成骨细胞数量显著增加(p <；0.05)。对照组（C30和C60）和治疗组（T30和T60）成骨细胞中Runx2和Osterix的表达均显著升高(p <；0.05)。结论脐带间充质干细胞通过成骨细胞、Runx2和Osterix促进糖尿病根尖牙周炎动物模型的骨再生。

{"title":"Umbilical cord mesenchymal stem cells improve bone regeneration in diabetes mellitus animal model with apical periodontitis","authors":"Eric Priyo Prasetyo , Pravinna Saravanan , Deaniddo Kharisna , Christina Immee Wijanarko , Mefina Kuntjoro , Nike Hendrijantini , Evelyn Tjendronegoro","doi":"10.1016/j.jobcr.2024.11.009","DOIUrl":"10.1016/j.jobcr.2024.11.009","url":null,"abstract":"<div><h3>Background</h3><div>Previous studies revealed diabetes mellitus subjects tend to have persistent apical periodontitis. Regenerative stem cells therapy through endodontic procedure is hoped to be a solution. This study assessed bone regeneration in diabetic rats with apical periodontitis through histopathological analysis of osteoblasts and immunohistochemical analysis of runt-related transcription factor 2 (Runx2) and Osterix.</div></div><div><h3>Methods</h3><div>Diabetes mellitus and apical periodontitis was induced on 20 rats. Apical periodontitis was induced on mandibular right first molars under anesthesia. The teeth were left open for 7 days following access cavity and pulp extirpation, then the rats’ teeth were endodontically treated and randomly allocated into 4 groups (5 rats per group). The first and second groups was ended at 30 days (C30) and 60 days (C60) and labelled as control. The third and fourth groups was given umbilical cord mesenchymal stem cells and ended at 30 days (T30) and 60 days (T60). The osteoblasts, Runx2 and Osterix were analyzed. ANOVA and Tukey HSD tests were used for analysis. Differences with p values < 0.05 were considered significant.</div></div><div><h3>Results</h3><div>The number of osteoblasts in the apical area in control groups (C30 and C60) and treatment groups (T30 and T60) showed a significant increase (p < 0.05). The expressions of Runx2 and Osterix in osteoblasts showed a significant increase among the control (C30 and C60) and treatment groups (T30 and T60) (p < 0.05).</div></div><div><h3>Conclusion</h3><div>Umbilical cord mesenchymal stem cells improve bone regeneration in diabetic animal model with apical periodontitis, in terms of osteoblasts, Runx2 and Osterix.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 16-21"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the accuracy of a simplified hybrid method versus the traditional digital method for measuring palatal volume 评估简化混合法与传统数字法测量腭部容积的准确性

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-26 DOI: 10.1016/j.jobcr.2024.10.011

Shailendra Singh Rana , Sharvari Vichare , Abhishek Gupta , Anjana Rajagopalan , Om Prakash Kharbanda

Objective

This study aimed to compare a direct conventional 3D digital technique vis a vis a hybrid method in measuring palatal volume.

Materials and methods

Thirty maxillary casts were obtained from the records of patients undergoing orthodontic treatment and pre-conceived boundaries of the palatal vault were marked. Sample was categorised into Group I (Volume estimation using CBCT scan) and Group II (Volume estimation using hybrid method). Estimation of the palatal volume in this study involved filling the volume of interest in the palate with gypsum (Type IV) stone material and carefully carving according to the boundaries and anatomy. This positive reproduction of the palatal space was safely retrieved and then scanned in the NewTom GiANO HR Cone Beam Imaging setup. The obtained scan was analysed in NNT Software Version 3.10 and the volume of the palate was calculated. Two experienced orthodontists carried out the measurements to evaluate the inter and intra-observer reliability. This was compared with the palatal volume calculated by the conventional digital method using CBCT in the NNT Software.

Result

This study showed a consistent and narrow range of the confidence interval for palatal volume. Hence, the sample size was sufficient and had good precision. Considering a 95 % confidence interval, the intra-class correlation coefficient was robust (>0.9) for all measurements calculated by the hybrid method suggesting a high reliability. The mean difference in measurement of palatal volume (Group I vs, Group II) was 1.37 + 0.64 mm3 and the difference was statistically insignificant. Statistical t-test conducted between the two methods showed a p-value of 0.34, implying no statistically significant difference between the two methods.

Conclusion

The hybrid method for evaluating the palatal volume is simple, accurate and comparable to the conventional digital method. A major advantage of this simplified method is that the patient is not exposed to any radiation of CBCT. Also, need for a specific skillset for digitally measuring the palatal volume is not a must.

材料和方法从接受正畸治疗的患者记录中获取 30 个上颌骨铸模，并标记出预先设想的腭穹边界。样本被分为第一组（使用 CBCT 扫描估算体积）和第二组（使用混合方法估算体积）。在这项研究中，腭部容积的估算是用石膏（IV 型）石料填充腭部感兴趣的容积，并根据边界和解剖结构仔细雕刻。腭部空间的正面再现被安全提取出来，然后在 NewTom GiANO HR 锥形束成像装置中进行扫描。扫描结果通过 NNT 软件 3.10 版进行分析，并计算出腭部的体积。由两名经验丰富的正畸医生进行测量，以评估观察者之间和观察者内部的可靠性。结果这项研究显示，腭部体积的置信区间一致且范围较窄。因此，样本量充足且精确度高。考虑到 95% 的置信区间，混合法计算出的所有测量值的类内相关系数都很稳健（0.9），表明可靠性很高。腭部体积测量的平均差异（第一组与第二组）为 1.37 + 0.64 mm3，差异在统计学上不显著。在两种方法之间进行的统计 t 检验显示 p 值为 0.34，这意味着两种方法之间没有显著的统计学差异。这种简化方法的主要优点是患者不会受到 CBCT 的任何辐射。此外，数字化测量腭部容积不需要特定的技能。

{"title":"Evaluation of the accuracy of a simplified hybrid method versus the traditional digital method for measuring palatal volume","authors":"Shailendra Singh Rana , Sharvari Vichare , Abhishek Gupta , Anjana Rajagopalan , Om Prakash Kharbanda","doi":"10.1016/j.jobcr.2024.10.011","DOIUrl":"10.1016/j.jobcr.2024.10.011","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to compare a direct conventional 3D digital technique vis a vis a hybrid method in measuring palatal volume.</div></div><div><h3>Materials and methods</h3><div>Thirty maxillary casts were obtained from the records of patients undergoing orthodontic treatment and pre-conceived boundaries of the palatal vault were marked. Sample was categorised into Group I (Volume estimation using CBCT scan) and Group II (Volume estimation using hybrid method). Estimation of the palatal volume in this study involved filling the volume of interest in the palate with gypsum (Type IV) stone material and carefully carving according to the boundaries and anatomy. This positive reproduction of the palatal space was safely retrieved and then scanned in the NewTom GiANO HR Cone Beam Imaging setup. The obtained scan was analysed in NNT Software Version 3.10 and the volume of the palate was calculated. Two experienced orthodontists carried out the measurements to evaluate the inter and intra-observer reliability. This was compared with the palatal volume calculated by the conventional digital method using CBCT in the NNT Software.</div></div><div><h3>Result</h3><div>This study showed a consistent and narrow range of the confidence interval for palatal volume. Hence, the sample size was sufficient and had good precision. Considering a 95 % confidence interval, the intra-class correlation coefficient was robust (>0.9) for all measurements calculated by the hybrid method suggesting a high reliability. The mean difference in measurement of palatal volume (Group I vs, Group II) was 1.37 + 0.64 mm3 and the difference was statistically insignificant. Statistical <em>t</em>-test conducted between the two methods showed a p-value of 0.34, implying no statistically significant difference between the two methods.</div></div><div><h3>Conclusion</h3><div>The hybrid method for evaluating the palatal volume is simple, accurate and comparable to the conventional digital method. A major advantage of this simplified method is that the patient is not exposed to any radiation of CBCT. Also, need for a specific skillset for digitally measuring the palatal volume is not a must.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 5-10"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparative evaluation of retention of record bases fabricated digitally in various types of posterior palatal seal area 以数字方式制作的记录基座在各种类型的腭后密封区的保留情况比较评估

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-26 DOI: 10.1016/j.jobcr.2024.11.004

Swapna Bettanapalya Venkatesh , Vaishnavi M. Nayak , Kavishma Sulaya , Smitha Sammith Shetty

Objectives

Intraoral scanners used for the fabrication of milled and 3D-printed complete dentures simplify the procedure. However, its effectiveness in recording the functional peripheral seal area needs to be researched. Therefore, this study aims to assess the retention of conventional, milled and 3D-printed denture bases made from conventional impression technique and digital scans in different types of post palatal seal area.

Material and method

Completely edentulous participants were divided into group A and group B based on type of posterior palatal seal area. Each group received three denture bases fabricated using compression molding, milling and 3D printing. The retention was evaluated using a digital dynamometer at 45° and 90° inclination.

Results

The ANOVA test revealed statistically significant difference in the retention of denture bases fabricated using three different techniques. When compared between the three groups at 45 and 90°, statistically significant difference in the retentive values between the control and other two groups were observed.

Conclusion

All three of the fabrication processes have retention that falls within a clinically acceptable range. 3D printed dentures had better adaptation on the PPS area whereas the milled dentures had a better peripheral seal although the conventional process showed highest retention values.

目的口内扫描仪用于制作铣制和三维打印的全口义齿，简化了制作过程。然而，它在记录功能性周边密封区方面的有效性还有待研究。因此，本研究旨在评估使用传统印模技术和数字扫描技术制作的传统义齿基托、铣制义齿基托和三维打印义齿基托在不同类型的腭后封闭区的固位情况。每组接受三个使用压缩成型、铣削和三维打印技术制作的义齿基托。结果方差分析检验显示，使用三种不同技术制作的义齿基托的固位情况存在显著的统计学差异。三组在 45° 和 90° 倾角下的固位值比较结果显示，对照组和其他两组的固位值在统计学上有显著差异。三维打印义齿对 PPS 区域的适应性更好，而研磨义齿的周边密封性更好，尽管传统工艺显示出最高的固位值。

{"title":"A comparative evaluation of retention of record bases fabricated digitally in various types of posterior palatal seal area","authors":"Swapna Bettanapalya Venkatesh , Vaishnavi M. Nayak , Kavishma Sulaya , Smitha Sammith Shetty","doi":"10.1016/j.jobcr.2024.11.004","DOIUrl":"10.1016/j.jobcr.2024.11.004","url":null,"abstract":"<div><h3>Objectives</h3><div>Intraoral scanners used for the fabrication of milled and 3D-printed complete dentures simplify the procedure. However, its effectiveness in recording the functional peripheral seal area needs to be researched. Therefore, this study aims to assess the retention of conventional, milled and 3D-printed denture bases made from conventional impression technique and digital scans in different types of post palatal seal area.</div></div><div><h3>Material and method</h3><div>Completely edentulous participants were divided into group A and group B based on type of posterior palatal seal area. Each group received three denture bases fabricated using compression molding, milling and 3D printing. The retention was evaluated using a digital dynamometer at 45° and 90° inclination.</div></div><div><h3>Results</h3><div>The ANOVA test revealed statistically significant difference in the retention of denture bases fabricated using three different techniques. When compared between the three groups at 45 and 90°, statistically significant difference in the retentive values between the control and other two groups were observed.</div></div><div><h3>Conclusion</h3><div>All three of the fabrication processes have retention that falls within a clinically acceptable range. 3D printed dentures had better adaptation on the PPS area whereas the milled dentures had a better peripheral seal although the conventional process showed highest retention values.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 11-15"},"PeriodicalIF":0.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mouth opening variables amongst the North Indian population 北印度人的张口变量

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-22 DOI: 10.1016/j.jobcr.2024.11.003

Disha Dixit, Pavitra Rastogi, Nand Lal, Rameshwari Singhal

Background

For the clinician to conveniently perform an extensive oral examination, it is required to have a known normal range of maximum mouth opening (MMO). This study aims to establish a standard for calculating the normal range of mouth opening in the adult population of North India. The results of this research will have clinical implications for the treatment and diagnosis of diseases that affect the mouth opening in adults, either directly or indirectly.

Aim

To evaluate mean mouth opening in North Indian population and establish their correlation with age and gender.

Method

662 adults from North Indian population, 317 males and 345 females in the age range of 18–80 years were evaluated on their consent. Maximum mouth opening was measured using calibrated vernier calliper scale. This study was conducted in the Department of Periodontology, Faculty of Dental Sciences, King George Medical University, Lucknow.

Results

Males exhibited a higher mean MMO of 48.0 mm compared to females, who had a lower mean MMO of 45.1 mm among North Indian population of the country. In the statistical comparison of MMO between males and females within each age group, the results showed no significant differences.

Conclusion

Mouth opening of females is less than males in all age groups and it seems to decrease with age in all age groups in both males and females. The variability of MMO with age appears statistically similar for both genders.

背景为了方便临床医生进行广泛的口腔检查，需要了解最大张口度 (MMO) 的正常范围。本研究旨在为北印度成年人口腔张开的正常范围建立一个计算标准。本研究的结果将对直接或间接影响成人张口的疾病的治疗和诊断产生临床影响。方法在征得本人同意后，对来自北印度的 662 名成人进行评估，其中男性 317 人，女性 345 人，年龄范围在 18-80 岁之间。使用校准过的游标卡尺测量最大张口度。这项研究在勒克瑙乔治国王医科大学牙科学院牙周病学系进行。结果在该国的北印度人口中，男性的平均最大口腔张开度为 48.0 毫米，高于女性的 45.1 毫米。结论在所有年龄组中，女性的张口率都低于男性，而且在所有年龄组中，男性和女性的张口率似乎都随着年龄的增长而下降。从统计学角度看，女性和男性的张口率随年龄的变化相似。

{"title":"Mouth opening variables amongst the North Indian population","authors":"Disha Dixit, Pavitra Rastogi, Nand Lal, Rameshwari Singhal","doi":"10.1016/j.jobcr.2024.11.003","DOIUrl":"10.1016/j.jobcr.2024.11.003","url":null,"abstract":"<div><h3>Background</h3><div>For the clinician to conveniently perform an extensive oral examination, it is required to have a known normal range of maximum mouth opening (MMO). This study aims to establish a standard for calculating the normal range of mouth opening in the adult population of North India. The results of this research will have clinical implications for the treatment and diagnosis of diseases that affect the mouth opening in adults, either directly or indirectly.</div></div><div><h3>Aim</h3><div>To evaluate mean mouth opening in North Indian population and establish their correlation with age and gender.</div></div><div><h3>Method</h3><div>662 adults from North Indian population, 317 males and 345 females in the age range of 18–80 years were evaluated on their consent. Maximum mouth opening was measured using calibrated vernier calliper scale. This study was conducted in the Department of Periodontology, Faculty of Dental Sciences, King George Medical University, Lucknow.</div></div><div><h3>Results</h3><div>Males exhibited a higher mean MMO of 48.0 mm compared to females, who had a lower mean MMO of 45.1 mm among North Indian population of the country. In the statistical comparison of MMO between males and females within each age group, the results showed no significant differences.</div></div><div><h3>Conclusion</h3><div>Mouth opening of females is less than males in all age groups and it seems to decrease with age in all age groups in both males and females. The variability of MMO with age appears statistically similar for both genders.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"15 1","pages":"Pages 1-4"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative evaluation of the degree of conversion of an 8th-generation bonding agent when applied to normal dentin or caries-affected dentin, pre-treated with MMP inhibitors – An in vitro study 在使用 MMP 抑制剂预处理的正常牙本质或受龋病影响的牙本质上使用第八代粘接剂时的转化程度比较评估 - 体外研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-01 DOI: 10.1016/j.jobcr.2024.10.010

Neil Vincent Lewis, Shalini Aggarwal (Dr), Prasanna Dhatavkar

Introduction

The degree of conversion of dentin bonding agents contributes to the success of final restorations in adhesive dentistry. It is clinically relevant, as it is directly related to the overall bond strength that maintains these restorations in place and prevents marginal deterioration. However, Matrix metalloproteinases (MMPs) present within the dentin substrate have been known to have a deleterious effect on the bond stability, due to their collagenolytic activity. Inhibition of the effects of MMPs has been studied, and the use of a pre-treatment protocol that includes MMP inhibiting agents before bonding procedures has been explored, and has been found to increase bond strengths. However, the effect that MMP inhibitors have on dental adhesives has not yet been explored, particularly when being used in caries-affected-dentin (CAD). This study aims to report the degree of conversion of an 8th-generation dentin bonding agent in sound dentin (SD) vs caries-affected dentin after pre-treatment using MMP inhibitors.

Materials & methods

60 dentin discs were divided into groups of sound and affected dentin, and pretreated with either Cranberry extract or mulberry extract was applied to half of the discs in each group, followed by the application of an eight-generation bonding agent to the pre-treated discs, which were then light cured. The degree of conversion of the adhesive was calculated using ATR-FTIR spectroscopy.

Results

The degree of conversion was found to be the highest in the samples of sound dentin which were pre-treated with Mulberry extract.

Conclusion

Pre-treatment of the dentin with MMP inhibitors led to an increase in the degree of conversion in sound dentin but not in CAD.

导言牙本质粘接剂的转化程度有助于粘接牙科中最终修复体的成功。它与临床相关，因为它直接关系到维持这些修复体就位和防止边缘退化的整体粘接强度。然而，存在于牙本质基质中的基质金属蛋白酶（MMPs）由于具有溶解胶原的活性，对粘接稳定性有有害影响。人们已经对抑制 MMPs 的作用进行了研究，并探索了在粘接程序前使用包括 MMP 抑制剂在内的预处理方案，结果发现这种方法可以提高粘接强度。然而，MMP 抑制剂对牙科粘合剂的影响尚未得到探讨，尤其是在受龋齿影响的牙本质（CAD）中使用时。本研究旨在报告使用 MMP 抑制剂进行预处理后，第八代牙本质粘接剂在健全牙本质（SD）与龋坏影响牙本质中的转化程度。使用 ATR-FTIR 光谱计算粘合剂的转化程度。结果发现，使用桑葚提取物预处理的健全牙本质样本的转化程度最高。

{"title":"Comparative evaluation of the degree of conversion of an 8th-generation bonding agent when applied to normal dentin or caries-affected dentin, pre-treated with MMP inhibitors – An in vitro study","authors":"Neil Vincent Lewis, Shalini Aggarwal (Dr), Prasanna Dhatavkar","doi":"10.1016/j.jobcr.2024.10.010","DOIUrl":"10.1016/j.jobcr.2024.10.010","url":null,"abstract":"<div><h3>Introduction</h3><div>The degree of conversion of dentin bonding agents contributes to the success of final restorations in adhesive dentistry. It is clinically relevant, as it is directly related to the overall bond strength that maintains these restorations in place and prevents marginal deterioration. However, Matrix metalloproteinases (MMPs) present within the dentin substrate have been known to have a deleterious effect on the bond stability, due to their collagenolytic activity. Inhibition of the effects of MMPs has been studied, and the use of a pre-treatment protocol that includes MMP inhibiting agents before bonding procedures has been explored, and has been found to increase bond strengths. However, the effect that MMP inhibitors have on dental adhesives has not yet been explored, particularly when being used in caries-affected-dentin (CAD). This study aims to report the degree of conversion of an 8th-generation dentin bonding agent in sound dentin (SD) vs caries-affected dentin after pre-treatment using MMP inhibitors.</div></div><div><h3>Materials & methods</h3><div>60 dentin discs were divided into groups of sound and affected dentin, and pretreated with either Cranberry extract or mulberry extract was applied to half of the discs in each group, followed by the application of an eight-generation bonding agent to the pre-treated discs, which were then light cured. The degree of conversion of the adhesive was calculated using ATR-FTIR spectroscopy.</div></div><div><h3>Results</h3><div>The degree of conversion was found to be the highest in the samples of sound dentin which were pre-treated with Mulberry extract.</div></div><div><h3>Conclusion</h3><div>Pre-treatment of the dentin with MMP inhibitors led to an increase in the degree of conversion in sound dentin but not in CAD.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 808-814"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antimicrobial role of Lavandula angustifolia towards Candida albicans, Streptococcus mutans, Staphylococcus aureus and anti-adherence effect on denture base resin 薰衣草对白色念珠菌、变异链球菌、金黄色葡萄球菌的抗菌作用以及对义齿基托树脂的抗粘附作用

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-01 DOI: 10.1016/j.jobcr.2024.10.014

Anitha Kuttae Viswanathan , Rajkumar Krishnan

Objectives

The objective of the study was to determine the antimicrobial efficacy of Lavandula angustifolia (True Lavender extract) towards Candida albicans, Streptococcus mutans, Staphylococcus aureus pathogens. Varying proportions of the extract was incorporated into polymethyl methacrylate (PMMA) denture base resin and the anti-adherent effect was investigated.

Methods

An in-vitro study was performed after pure extract was obtained from Lavandula angustifolia (LA) flowers using a solvent based hot extraction process. Chromatographic analysis and computational molecular docking were done to analyze its phytoconstituents with potential target-ligand bond. Tests of antimicrobial susceptibility, minimum inhibitory concentration, minimum bactericidal and fungicidal dosages and in-vitro cytotoxicity were performed. Different proportions of LA extract (0, .5, 1.0, 1.5, and 2.0 %) were added to PMMA resin to assess anti-adherence property. Obtained data were statistically analyzed with One-way ANOVA followed by Tukey post-hoc tests.

Results

The reports revealed significant antimicrobial susceptibility against the test pathogens compared to control drugs (P > 0.05). A minimum concentration of .02 mg of lavender extract inhibited microbial growth with low cytotoxicity (P < 0.05). The highest anti-adherent activity was observed in the .5 % LA-incorporated PMMA resin group (P = 0.0001).

Conclusions

Incorporating lavender extract into denture base resin demonstrated promising antimicrobial properties. This investigation encourages further research to understand its effects on mechanical and physical properties of reinforced dental resins.

研究目的：确定薰衣草（真薰衣草提取物）对白色念珠菌、变异链球菌和金黄色葡萄球菌病原体的抗菌效果。将不同比例的萃取物加入聚甲基丙烯酸甲酯（PMMA）义齿基底树脂中，研究了其抗粘连效果。色谱分析和计算分子对接分析了其植物成分与潜在目标配体的结合。进行了抗菌敏感性、最小抑菌浓度、最小杀菌和杀真菌剂量以及体外细胞毒性测试。将不同比例的 LA 提取物（0、.5、1.0、1.5 和 2.0 %）添加到 PMMA 树脂中，以评估抗粘附性。结果报告显示，与对照组药物相比，LA 提取物对测试病原体具有显著的抗菌敏感性（P > 0.05）。最低浓度为 0.02 毫克的薰衣草提取物可抑制微生物生长，但细胞毒性较低（P< 0.05）。结论在义齿基底树脂中加入薰衣草提取物具有良好的抗菌特性。这项调查鼓励人们进一步研究薰衣草提取物对增强型牙科树脂的机械和物理特性的影响。

{"title":"Antimicrobial role of Lavandula angustifolia towards Candida albicans, Streptococcus mutans, Staphylococcus aureus and anti-adherence effect on denture base resin","authors":"Anitha Kuttae Viswanathan , Rajkumar Krishnan","doi":"10.1016/j.jobcr.2024.10.014","DOIUrl":"10.1016/j.jobcr.2024.10.014","url":null,"abstract":"<div><h3>Objectives</h3><div>The objective of the study was to determine the antimicrobial efficacy of Lavandula angustifolia (True Lavender extract) towards Candida albicans, Streptococcus mutans, Staphylococcus aureus pathogens. Varying proportions of the extract was incorporated into polymethyl methacrylate (PMMA) denture base resin and the anti-adherent effect was investigated.</div></div><div><h3>Methods</h3><div>An in-vitro study was performed after pure extract was obtained from Lavandula angustifolia (LA) flowers using a solvent based hot extraction process. Chromatographic analysis and computational molecular docking were done to analyze its phytoconstituents with potential target-ligand bond. Tests of antimicrobial susceptibility, minimum inhibitory concentration, minimum bactericidal and fungicidal dosages and in-vitro cytotoxicity were performed. Different proportions of LA extract (0, .5, 1.0, 1.5, and 2.0 %) were added to PMMA resin to assess anti-adherence property. Obtained data were statistically analyzed with One-way ANOVA followed by Tukey post-hoc tests.</div></div><div><h3>Results</h3><div>The reports revealed significant antimicrobial susceptibility against the test pathogens compared to control drugs (P > 0.05). A minimum concentration of .02 mg of lavender extract inhibited microbial growth with low cytotoxicity (P < 0.05). The highest anti-adherent activity was observed in the .5 % LA-incorporated PMMA resin group (P = 0.0001).</div></div><div><h3>Conclusions</h3><div>Incorporating lavender extract into denture base resin demonstrated promising antimicrobial properties. This investigation encourages further research to understand its effects on mechanical and physical properties of reinforced dental resins.</div></div>","PeriodicalId":16609,"journal":{"name":"Journal of oral biology and craniofacial research","volume":"14 6","pages":"Pages 815-824"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0