Journal of oral biology and craniofacial research最新文献_第3页

Comparative evaluation of the degree of conversion of an 8th-generation bonding agent when applied to normal dentin or caries-affected dentin, pre-treated with MMP inhibitors – An in vitro study 在使用 MMP 抑制剂预处理的正常牙本质或受龋病影响的牙本质上使用第八代粘接剂时的转化程度比较评估 - 体外研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-01 DOI: 10.1016/j.jobcr.2024.10.010

Neil Vincent Lewis, Shalini Aggarwal (Dr), Prasanna Dhatavkar

Introduction

The degree of conversion of dentin bonding agents contributes to the success of final restorations in adhesive dentistry. It is clinically relevant, as it is directly related to the overall bond strength that maintains these restorations in place and prevents marginal deterioration. However, Matrix metalloproteinases (MMPs) present within the dentin substrate have been known to have a deleterious effect on the bond stability, due to their collagenolytic activity. Inhibition of the effects of MMPs has been studied, and the use of a pre-treatment protocol that includes MMP inhibiting agents before bonding procedures has been explored, and has been found to increase bond strengths. However, the effect that MMP inhibitors have on dental adhesives has not yet been explored, particularly when being used in caries-affected-dentin (CAD). This study aims to report the degree of conversion of an 8th-generation dentin bonding agent in sound dentin (SD) vs caries-affected dentin after pre-treatment using MMP inhibitors.

Materials & methods

60 dentin discs were divided into groups of sound and affected dentin, and pretreated with either Cranberry extract or mulberry extract was applied to half of the discs in each group, followed by the application of an eight-generation bonding agent to the pre-treated discs, which were then light cured. The degree of conversion of the adhesive was calculated using ATR-FTIR spectroscopy.

Results

The degree of conversion was found to be the highest in the samples of sound dentin which were pre-treated with Mulberry extract.

Conclusion

Pre-treatment of the dentin with MMP inhibitors led to an increase in the degree of conversion in sound dentin but not in CAD.

导言牙本质粘接剂的转化程度有助于粘接牙科中最终修复体的成功。它与临床相关，因为它直接关系到维持这些修复体就位和防止边缘退化的整体粘接强度。然而，存在于牙本质基质中的基质金属蛋白酶（MMPs）由于具有溶解胶原的活性，对粘接稳定性有有害影响。人们已经对抑制 MMPs 的作用进行了研究，并探索了在粘接程序前使用包括 MMP 抑制剂在内的预处理方案，结果发现这种方法可以提高粘接强度。然而，MMP 抑制剂对牙科粘合剂的影响尚未得到探讨，尤其是在受龋齿影响的牙本质（CAD）中使用时。本研究旨在报告使用 MMP 抑制剂进行预处理后，第八代牙本质粘接剂在健全牙本质（SD）与龋坏影响牙本质中的转化程度。使用 ATR-FTIR 光谱计算粘合剂的转化程度。结果发现，使用桑葚提取物预处理的健全牙本质样本的转化程度最高。

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引用次数: 0

Antimicrobial role of Lavandula angustifolia towards Candida albicans, Streptococcus mutans, Staphylococcus aureus and anti-adherence effect on denture base resin 薰衣草对白色念珠菌、变异链球菌、金黄色葡萄球菌的抗菌作用以及对义齿基托树脂的抗粘附作用

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-01 DOI: 10.1016/j.jobcr.2024.10.014

Anitha Kuttae Viswanathan , Rajkumar Krishnan

Objectives

The objective of the study was to determine the antimicrobial efficacy of Lavandula angustifolia (True Lavender extract) towards Candida albicans, Streptococcus mutans, Staphylococcus aureus pathogens. Varying proportions of the extract was incorporated into polymethyl methacrylate (PMMA) denture base resin and the anti-adherent effect was investigated.

Methods

An in-vitro study was performed after pure extract was obtained from Lavandula angustifolia (LA) flowers using a solvent based hot extraction process. Chromatographic analysis and computational molecular docking were done to analyze its phytoconstituents with potential target-ligand bond. Tests of antimicrobial susceptibility, minimum inhibitory concentration, minimum bactericidal and fungicidal dosages and in-vitro cytotoxicity were performed. Different proportions of LA extract (0, .5, 1.0, 1.5, and 2.0 %) were added to PMMA resin to assess anti-adherence property. Obtained data were statistically analyzed with One-way ANOVA followed by Tukey post-hoc tests.

Results

The reports revealed significant antimicrobial susceptibility against the test pathogens compared to control drugs (P > 0.05). A minimum concentration of .02 mg of lavender extract inhibited microbial growth with low cytotoxicity (P < 0.05). The highest anti-adherent activity was observed in the .5 % LA-incorporated PMMA resin group (P = 0.0001).

Conclusions

Incorporating lavender extract into denture base resin demonstrated promising antimicrobial properties. This investigation encourages further research to understand its effects on mechanical and physical properties of reinforced dental resins.

研究目的：确定薰衣草（真薰衣草提取物）对白色念珠菌、变异链球菌和金黄色葡萄球菌病原体的抗菌效果。将不同比例的萃取物加入聚甲基丙烯酸甲酯（PMMA）义齿基底树脂中，研究了其抗粘连效果。色谱分析和计算分子对接分析了其植物成分与潜在目标配体的结合。进行了抗菌敏感性、最小抑菌浓度、最小杀菌和杀真菌剂量以及体外细胞毒性测试。将不同比例的 LA 提取物（0、.5、1.0、1.5 和 2.0 %）添加到 PMMA 树脂中，以评估抗粘附性。结果报告显示，与对照组药物相比，LA 提取物对测试病原体具有显著的抗菌敏感性（P > 0.05）。最低浓度为 0.02 毫克的薰衣草提取物可抑制微生物生长，但细胞毒性较低（P< 0.05）。结论在义齿基底树脂中加入薰衣草提取物具有良好的抗菌特性。这项调查鼓励人们进一步研究薰衣草提取物对增强型牙科树脂的机械和物理特性的影响。

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引用次数: 0

Top 100 most cited economic evaluation papers of preventive oral health programmes: A bibliometric analysis 被引用次数最多的 100 篇口腔预防保健计划经济评估论文：文献计量分析

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-01 DOI: 10.1016/j.jobcr.2024.10.012

Lekshmi Anand , P. Gayathri , Vineetha Karuveettil , M. Anjali

Objective

To identify the trends of the top 100 cited articles on economic evaluation in preventive oral health programs.

Methods

Top 100 papers involving economic evaluation or cost analysis of preventive oral health programs were selected by querying Scopus and Web of Science databases. Bibliometric analysis was performed using the Bibliometrix tool in R Studio. Performance analysis and science mapping were performed for these 100 articles. Performance analysis included publication-related metrics, citation-related metrics, and citation-publication-related metrics. Science mapping provided information on citation analysis, co-citation analysis, bibliographic coupling, co-word analysis, and co-authorship details.

Results

The total citation number of the top 100 most cited articles ranged from 4 to 98, with publication dates spanning from 1978 to 2023. The majority of articles (33.70 %) originated from the USA, while Community Dentistry and Oral Epidemiology stood out as the journal with the highest number of articles published in the top 100 (16 out of 100). Griffin PM emerged as the most cited author, based on the frequency measurement of the number of papers. Program data economic evaluation was the most commonly reported study design, and fluoridation programs were the most frequent topic. The most reported type of economic analysis performed in the articles was cost-effectiveness analysis.

Conclusion

The bibliometric analysis of the top 100 most-cited articles on economic evaluation of preventive oral health programs revealed the lacunae in the research literature on this topic. Therefore, preventive oral health programs should be economically evaluated to eliminate the disparity in resource allocation particularly in upper middle income and low-income countries.

方法通过查询 Scopus 和 Web of Science 数据库，选出涉及口腔预防保健项目经济评估或成本分析的前 100 篇论文。使用 R Studio 中的 Bibliometrix 工具进行文献计量分析。对这 100 篇文章进行了绩效分析和科学绘图。绩效分析包括出版相关指标、引文相关指标和引文-出版相关指标。科学图谱提供了引文分析、共引分析、书目耦合、合著词分析和合著人详情等信息。结果被引次数最高的前 100 篇文章的总被引次数从 4 到 98 不等，发表日期从 1978 年到 2023 年不等。大多数文章（33.70%）来自美国，而《社区牙科与口腔流行病学》则是发表文章数量最多的期刊（100 篇中有 16 篇）。根据论文数量的频率测量，格里芬-帕姆成为被引用次数最多的作者。项目数据经济评价是最常报道的研究设计，氟化项目是最常报道的主题。结论对被引用次数最多的前 100 篇有关口腔预防保健计划经济评估的文章进行文献计量分析，发现了该主题研究文献的空白。因此，应该对口腔预防保健计划进行经济评估，以消除资源分配上的差异，尤其是在中高收入和低收入国家。

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引用次数: 0

Pharyngeal airway dimensions and hyoid bone position in children with class II malocclusion and sleep problems: A cross sectional study 有 II 类错牙合畸形和睡眠问题的儿童的咽气道尺寸和舌骨位置：横断面研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-01 DOI: 10.1016/j.jobcr.2024.11.001

Shreya S , Vabitha Shetty , Kavitha Ragu

Objective

To evaluate the pharyngeal airway width and hyoid bone position in children with class II malocclusion and a positive history of sleep problems.

Methods

60 children aged 8–12 years with skeletal class II malocclusion were segregated into two groups according to the existence of sleep problems: 30 participants with sleep disorders constituted the study group, while 30 participants without sleep disorders formed the control group. Pharyngeal airway space and hyoid bone position were evaluated via a clinical and radiographic examination.

Results

A significantly narrower upper pharyngeal airway width and decreased C3-H hyoid parameter was noted in children with sleep problems (p = 0.035, 0.012).

Conclusion

Both pharyngeal airway parameters and the hyoid bone parameters could be potential risk indicators while screening for sleep-disordered breathing in children.

方法根据存在睡眠问题的情况，将60名8-12岁骨骼Ⅱ类错颌畸形儿童分为两组：30名有睡眠障碍的儿童为研究组，30名无睡眠障碍的儿童为对照组。结果发现，有睡眠问题的儿童咽上气道宽度明显变窄，C3-H舌骨参数下降（p = 0.035，0.012）。结论在筛查儿童睡眠呼吸障碍时，咽气道参数和舌骨参数都可能是潜在的风险指标。

引用次数: 0

Comparative evaluation of efficacy of guided endodontic technique with and without sleeve for access cavity preparation: An In Vitro study 带套筒和不带套筒引导牙髓治疗技术的疗效比较评估体外研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-11-01 DOI: 10.1016/j.jobcr.2024.10.013

Varun Prabhuji , S. Archana , A. Srirekha , Veena Pai , C. Champa , Ashwija Shetty

Background

Calcific metamorphosis in root canals is common and presents challenges in gaining access. Guided endodontics offers a solution to overcome these difficulties. The PriciGuide® system is a patented guided endodontic technique claiming superior precision compared to sleeve-based guides. This study aims to compare deviation between the PriciGuide® system and the guide with sleeve.

Methods

A patient with calcified canal underwent CBCT scanning to obtain a DICOM file. Using the DICOM file, 3D models were printed. The patient's cast was scanned to obtain an STL file. Using DICOM and STL files, the guide with sleeve was designed using BlueSkyBio software and 3D printed. The PriciGuide® system was obtained from Roots to Cusps® Private Limited. Access opening was performed using conventional method, guide with sleeve and guide without sleeve (PriciGuide® system).

Samples underwent radiograph scans to measure coronal, apical, and angular deviations, as well as procedural time.

Results

One-Way ANOVA and Post Hoc Bonferroni's test revealed that coronal, apical, and angular deviations were lowest in the guide without sleeve group. However, access opening times were similar in both guided technique groups.

Conclusions

The PriciGuide® system offers precise access cavity preparation for calcified canals, showing minimal deviation compared to the sleeve-based guides. It facilitates accurate root canal access regardless of the dentist's experience level. This study utilized 3D-printed teeth that do not fully replicate the complexities of natural teeth, further research is needed to validate the PriciGuide® system's performance on natural teeth and assess deviation using CBCT for a more comprehensive evaluation.

背景根管变形是一种常见现象，给进入根管带来了挑战。引导根管治疗为克服这些困难提供了一种解决方案。PriciGuide® 系统是一种获得专利的引导式根管治疗技术，与套筒式引导器相比，它具有更高的精确度。本研究旨在比较 PriciGuide® 系统与套筒式引导器之间的偏差。使用 DICOM 文件打印三维模型。扫描患者的石膏以获得 STL 文件。使用 DICOM 和 STL 文件，使用 BlueSkyBio 软件设计了带套筒的导板，并进行了三维打印。PriciGuide® 系统由 Roots to Cusps® 私人有限公司提供。使用传统方法、带套筒导板和不带套筒导板（PriciGuide® 系统）进行通路打开。样本接受放射线扫描，以测量冠状面、根尖和角度偏差以及手术时间。结果单向方差分析和事后Bonferroni检验显示，不带套筒导板组的冠状面、根尖和角度偏差最小。结论PriciGuide®系统可为钙化根管提供精确的通路洞预备，与套筒导向器相比，偏差最小。无论牙医的经验水平如何，它都能促进根管的精确进入。本研究使用的 3D 打印牙齿并不能完全复制天然牙齿的复杂性，因此需要进一步研究来验证 PriciGuide® 系统在天然牙齿上的性能，并使用 CBCT 评估偏差，以进行更全面的评估。

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引用次数: 0

Evaluation of buccolingual and linguobuccal implants in the atrophic posterior mandible: A finite element analysis study 对萎缩性后下颌骨的颊舌和舌颊颊种植体进行评估：有限元分析研究

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-10-24 DOI: 10.1016/j.jobcr.2024.10.009

Moyfat Karimov , Goksel Timarcioglu , Celal Candirli

Aim

This study aims to evaluate the stress distribution on buccolingual and linguobuccal tilted implants in the atrophic posterior mandible using finite element analysis.

Material and methods

Twelve digital models of implants with varying lengths (8.5 mm, 10 mm, 11.5 mm) and angles (20°, 25°) were created. These implants were analyzed under 150 N vertical and oblique forces to assess stress distribution on both implants and surrounding bone.

Results

Linguobuccal implants generally exhibited lower maximum principal stress in cortical bone, while buccolingual implants showed lower minimum principal stress. Longer implants reduced stress under oblique loading.

Conclusion

Tilted implants, particularly using the linguobuccal method, are effective for stress distribution in the atrophic posterior mandible. Further research should explore varying implant diameters and multiple placements for optimization.

材料和方法制作了 12 个不同长度（8.5 毫米、10 毫米、11.5 毫米）和角度（20°、25°）的种植体数字模型。在 150 N 垂直力和斜向力作用下对这些种植体进行分析，以评估种植体和周围骨质的应力分布。结论倾斜种植体，尤其是使用舌颊面种植体的方法，对萎缩下颌后部的应力分布很有效。进一步的研究应该探索不同直径的种植体和多种植入方式，以达到最佳效果。

引用次数: 0

Evaluation of efficacy of digital or virtual bite registration over conventional techniques- A systematic review 数字或虚拟咬合登记与传统技术相比的疗效评估--系统性综述

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-10-24 DOI: 10.1016/j.jobcr.2024.10.007

Priyanjali Paul, Tridib Nath Banerjee, Saurav Banerjee, Anasua Debnath

Background

Bite registration procedures have been transformed by the digital revolution in dentistry, thus it is now necessary to compare the accuracy of digital or virtual techniques to conventional ones.

Aim

To assess the accuracy of digital or virtual bite registration systems in comparison to conventional methods to clarify any potential advantages or disadvantages.

Methodology

A thorough search in numerous databases, including PubMed, Embase, the Cochrane Library, Scopus, and Web of Science, was carried out in accordance with PRISMA criteria. The review focused on the accuracy of digital or virtual bite registration and covered a variety of study formats, including randomized controlled trials, clinical studies, and in-vitro investigations. For each of the included 7 studies, a thorough assessment of bias was conducted using the Newcastle-Ottawa Scale and the Cochrane Risk of Bias tool. As there would be expected variability in study designs, data synthesis required both a narrative explanation of the results and a qualitative synthesis.

Results

This systematic review compared 7 studies on traditional bite registration methods versus digital/virtual techniques. Digital techniques highlighted improved efficiency and innovation with increased speed, accuracy, and integration advantages. Evaluations performed with the Newcastle-Ottawa Scale and ROBINS-I tool showed little bias in cross-sectional studies. Nevertheless, in vitro studies have identified biases in participant selection and result reporting, indicating a need for better study rigor and reporting standards. A study received a noteworthy 8 out of 9 score on the Newcastle-Ottawa Scale, indicating strong methodology with careful sample selection, solid comparability, and comprehensive outcome evaluation, enhancing its credibility in assessing bite registration techniques.

Conclusion

The benefits of digital/virtual bite registration methods over traditional ones are demonstrated in this systematic review, which also shows how these methods improve speed, accuracy, and integration. Although some studies have shown biases, overall results support the validity and efficiency of digital techniques in improving dental practice.

背景牙科数字化革命改变了咬合登记程序，因此现在有必要比较数字化或虚拟技术与传统技术的准确性。目的评估数字化或虚拟咬合登记系统与传统方法相比的准确性，以明确任何潜在的优势或劣势。方法根据 PRISMA 标准在众多数据库（包括 PubMed、Embase、Cochrane 图书馆、Scopus 和 Web of Science）中进行了全面搜索。综述的重点是数字化或虚拟咬合登记的准确性，涵盖了各种研究形式，包括随机对照试验、临床研究和体外调查。对于每项纳入的 7 项研究，我们都使用纽卡斯尔-渥太华量表和 Cochrane 偏倚风险工具进行了全面的偏倚评估。由于研究设计存在预期差异，因此数据综合既需要对结果进行叙述性解释，也需要进行定性综合。数字技术具有速度快、准确性高和集成度高等优点，突出了效率和创新性。使用纽卡斯尔-渥太华量表和 ROBINS-I 工具进行的评估显示，横断面研究中的偏差很小。然而，体外研究发现，在参与者选择和结果报告方面存在偏差，这表明有必要提高研究的严谨性和报告标准。一项研究在纽卡斯尔-渥太华量表中获得了值得一提的 8 分（满分 9 分），表明该研究方法严谨，样本选择仔细，可比性强，结果评估全面，提高了其在评估咬合登记技术方面的可信度。虽然有些研究存在偏差，但总体结果支持数字化技术在改善牙科实践中的有效性和效率。

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引用次数: 0

Mari's novel T shaped incision in frenotomy technique with bilateral pedicle flap- an aesthetic approach Mari 在双侧椎弓根皮瓣腱索切开术中采用新颖的 T 形切口--一种美学方法

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-10-22 DOI: 10.1016/j.jobcr.2024.09.008

K. Rudhra , Ranjith Mari , Anitha Balaji , Mohan Valiathan

Background

Aberrant frenum attachments often lead to mucogingival deformities, culminating in both functional impairments and aesthetic concerns. Traditional frenectomy procedures are associated with extensive incisions and resultant wound defects. To address these challenges, a novel T-shaped incision technique has been developed. This method enhances accessibility for removing vestibular and frenal attachments while creating a tripod layer of flaps, thereby promoting primary closure and improved blood supply for healing by primary intention.

Case management

This innovative technique is particularly suited for managing frenum variations such as bifid frenum, persistent tectolabial frenum, double frenum, and wider frenum. The procedure involves crafting two horizontal and two converging parallel incisions that form a “T" shape, facilitating effective fiber detachment. Bilateral pedicle flaps are then employed for primary closure, which concurrently enlarges the zone of attached gingiva.

Conclusion

The T-shaped incision approach presents an advanced method for treating abnormal frenum attachments, ensuring efficient fiber separation and fostering healing by primary intention.

背景尖锐的龈缘附着常常导致粘牙龈畸形，最终造成功能障碍和美观问题。传统的龈沟切除术切口大，会造成伤口缺损。为了应对这些挑战，我们开发了一种新颖的 T 形切口技术。这种方法提高了切除前庭和蹼附着物的可及性，同时创建了一个三脚架皮瓣层，从而促进原发闭合，改善血液供应，促进原发意向愈合。这种创新技术尤其适用于处理蹼的变异，如二叉蹼、持续性齿状蹼、双蹼和较宽的蹼。手术过程包括制作两个水平切口和两个会聚的平行切口，形成 "T "形，以便有效分离纤维。结论 "T "形切口法是治疗异常龈缘附着的一种先进方法，可确保有效的纤维分离并促进原发意向愈合。

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引用次数: 0

Unravelling the unique case of congenital infiltrating lipomatosis of face with its rare associations—A case report 揭秘面部先天性浸润性脂肪瘤病的独特病例及其罕见关联--病例报告

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-10-20 DOI: 10.1016/j.jobcr.2024.10.006

Ramandeep Singh , Aakash Gupta , Gaurav Shanker Pradhan , Arshit Kataria

Congenital infiltrating lipomatosis of facial (CIL-F) is a rare tumour of adipose tissue resulting in a progressive craniofacial deformity with involvement of the underlying bones, muscles and joints. We report a very rare case of CIL-F with left sided temporomandibular joint ankylosis in a young patient who presented with facial swelling and reduced mouth opening. This case highlights the imaging features, differential diagnosis and brief management of CIL-F with special emphasis on CT and MRI findings. Also, some associations of CIL-F such as TMJ ankylosis and extraocular muscle hypertrophy has been described, which has been reported very rarely.

先天性面部浸润性脂肪瘤病（CIL-F）是一种罕见的脂肪组织肿瘤，可导致进行性颅面部畸形，并累及下层骨骼、肌肉和关节。我们报告了一例非常罕见的伴有左侧颞下颌关节强直的 CIL-F 病例，患者年轻，面部肿胀，张口困难。本病例重点介绍了 CIL-F 的影像学特征、鉴别诊断和简要处理方法，特别强调了 CT 和 MRI 检查结果。此外，该病例还描述了颞下颌关节强直和眼外肌肥大等与 CIL-F 相关的一些症状，但这些症状很少见诸报道。

引用次数: 0

Myofibroblasts persist through immune privilege mechanisms to mediate oral submucous fibrosis: Uncovering the pathogenesis 肌成纤维细胞通过免疫特权机制持续介导口腔黏膜下纤维化：揭示发病机制

Q1 Medicine

Journal of oral biology and craniofacial research

Pub Date : 2024-10-20 DOI: 10.1016/j.jobcr.2024.10.008

Mohit Sharma , Smitha Sammith Shetty , Sonal Soi , Raghu Radhakrishnan

Immune privilege is the ability to tolerate foreign antigens without eliciting an inflammatory immune response. Several mechanisms explain a structure's immune privilege status, which is regulated by innate and adaptive immune responses. The role of myofibroblasts in perpetuating fibrosis by acquiring an immune privileged phenotype against the backdrop of oral submucous fibrosis (OSF) is evolving. Myofibroblasts persist through the Fas/FasL autocrine pathway and induce apoptosis in epithelial cells, explaining the juxtaposition of apoptotic cells in areas of fibrosis. However, increased matrix stiffness, in addition to activating TGF-β, reduces Fas surface expression in myofibroblasts, increasing their resistance to apoptosis. The reciprocal amplification loop between the immune checkpoint proteins programmed death-ligand 1 (PD-L1) and TGF-β involves the YAP-TAZ and SMAD2,3 pathways and dramatically enhances profibrotic signalling. Increased matrix stiffness also enhances cMYC expression, which subsequently amplifies PD-L1 levels on myofibroblasts. The increase in PD-L1 on the myofibroblast microengineers the phenotype of CD4⁺ T cells homing to fibrotic areas by acting on the programmed cell death protein 1 (PD-1) receptor on the T-cell surface, converting these cells from antifibrotic cells to profibrotic cells that produce IL-17A and TGF-β. This manuscript provides mechanistic insight into how myofibroblasts avoid apoptosis in OSFs by evading the immune system. Targeting an immune-privileged phenotype in myofibroblasts with FAS-FASL pathway-dependent characteristics is an ideal strategy for reversing OSF.

免疫特权是指在不引起炎症免疫反应的情况下耐受外来抗原的能力。一种结构的免疫特权状态受先天性免疫反应和适应性免疫反应的调节，有多种机制可以解释这种状态。在口腔黏膜下纤维化（OSF）的背景下，肌成纤维细胞通过获得免疫特权表型使纤维化永久化的作用正在不断发展。肌成纤维细胞通过 Fas/FasL 自分泌途径持续存在，并诱导上皮细胞凋亡，这就是纤维化区域凋亡细胞并存的原因。然而，基质硬度的增加除了激活 TGF-β 外，还降低了肌成纤维细胞中 Fas 的表面表达，增加了它们对细胞凋亡的抵抗力。免疫检查点蛋白程序性死亡配体 1（PD-L1）和 TGF-β 之间的相互放大循环涉及 YAP-TAZ 和 SMAD2,3 通路，并显著增强了促组织坏死的信号传导。基质硬度的增加也会增强 cMYC 的表达，进而放大肌成纤维细胞上的 PD-L1 水平。肌成纤维细胞上 PD-L1 的增加通过作用于 T 细胞表面的程序性细胞死亡蛋白 1（PD-1）受体，对归巢到纤维化区域的 CD4+ T 细胞的表型进行微观设计，将这些细胞从抗纤维化细胞转化为产生 IL-17A 和 TGF-β 的促纤维化细胞。这篇手稿从机理上揭示了肌成纤维细胞如何通过逃避免疫系统来避免OSF中的细胞凋亡。针对具有FAS-FASL通路依赖性特征的肌成纤维细胞的免疫特权表型是逆转OSF的理想策略。

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引用次数: 0