Journal of Nutrition最新文献

p-hydroxycinnamic acids (p-HCAs), a class of natural phenolic acid compounds extracted from plant resources and widely distributed, feature a C6-C3 phenylpropanoid structure. Their antioxidant, anti-inflammatory, and antibacterial activities have shown great potential for applications in food and animal feed. The interactions between p-HCAs and the gut microbiota, as well as their subsequent effects on animal health, have increasingly attracted the attention of researchers. In the context of a greener and safer future, the progress and innovation in biosynthetic technology have occupied a central position in ensuring the safety of food and feed. This review emphasizes the complex mechanisms underlying the interactions between p-HCAs and the gut microbiota, providing a solid explanation for the remarkable bioactivities of p-HCAs and their subsequent impact on animal health. Furthermore, it explores the advancements in the synthetic biology of p-HCAs. This review could aid in a basis for better understanding the underlying interactions between p-HCAs and gut microbiota and animal health.

Vitamin D is an essential fat-soluble vitamin for humans and vitamin D deficiency (VDD) affects all age groups, with older adults being at high risk of VDD. A deficiency in vitamin D has been associated with a range of health concerns in older adults, including osteomalacia and osteoporosis. Additionally, there is limited evidence suggesting that VDD may be associated with increased risk of developing cognitive impairment, muscle-wasting disorders, cardiovascular disease, type 2 diabetes mellitus, and mortality. This review synthesizes the latest research advances in China and abroad to provide detailed information on the current status of vitamin D nutritional monitoring, causes of deficiency, health risks, and proposed intake for reducing risk of diet-related noncommunicable diseases in the Chinese older adults.

Background: The intestinal development and nutritional needs of piglets after birth are similar to those of human infants.

Objectives: This study aimed to investigate the effect of different forms of odd-chain fatty acids (OCFAs) on the growth and intestinal morphology and function of milk replacer-fed piglets, as a model for human infants.

Methods: Forty 7-d-old piglets from 8 sows were randomly assigned into 5 groups (n = 8, each from a different litter) and fed sow milk or milk replacers supplemented with different kinds of fats (control fats, docosahexaenoic acid algal oil-, OCFA algal oil-, and OCFA-enriched fats) for 21 d. One-way analysis of variance was performed to compare the milk replacer-fed piglet groups, and unpaired t test was used to compare sow milk- and milk replacer-fed piglets.

Results: Milk replacers supplemented with OCFA-enriched fats increased the average daily gain (ADG), ratio of villus height to crypt depth, and protein expression of Ki67, phosphorylated (p)-mTOR, p-p70S6k, Occludin, Claudin, and ZO-1 in the selected intestines of piglets and decreased the protein expression of p-ULK1, Parkin, and PINK1 to levels similar to those of the sow milk-fed group (P < 0.05).

Conclusion: Overall, milk replacers supplemented with OCFA-enriched fats improved the ADG and the intestinal morphology and function of piglets to levels comparable to those of the sow milk-fed piglets.

Background: In addition to its important roles in blood coagulation and bone formation, vitamin K (VK) contributes to brain function. Low dietary VK intake, which is common among older adults, is associated with age-related cognitive impairment.

Objectives: To elucidate the biological mechanisms underlying VK's effects on cognition, we investigated the effects of low VK (LVK) intake on cognition in C57BL/6 mice.

Methods: Male and female 9-mo-old C57BL/6 mice (n = 60) were fed an LVK diet or a control diet for 6 mo. Behavioral tests were performed on a subset of mice (n = 26) at 15 mo, and brain tissues were collected for follow-up analyses.

Results: Menaquinone-4, the predominant VK form in the brain, was significantly lower in LVK mice compared to controls (15.6 ± 13.3 compared with 189 ± 186 pmol/g, respectively, P < 0.01). LVK mice showed reduced recognition memory in the novel object test by spending a lower percentage of time exploring the novel object compared to controls (47.45% ± 4.17 compared with 58.08% ± 3.03, P = 0.04). They also spent a significantly longer time learning the task of locating the platform in the Morris water maze test. Within the hippocampal dentate gyrus, LVK mice had a significantly lower number of proliferating cells and fewer newly generated immature neurons compared to control mice. Additionally, more activated microglia cells were identified in the LVK mice.

Conclusions: Our data indicate that LVK intake reduced menaquinone-4 concentrations in brain tissues and impaired learning- and memory-related cognitive function. This impairment may be related to the observed reduced hippocampal neurogenesis and elevated neural inflammation.