Journal of Nutrition最新文献

{"title":"Retinol Isotope Dilution Testing in Population-Based Surveys: Are We There Yet?","authors":"Sherry A Tanumihardjo","doi":"10.1016/j.tjnut.2025.01.032","DOIUrl":"10.1016/j.tjnut.2025.01.032","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Lifestyle Factors in Homocysteine Metabolism Research.","authors":"Isabell Franzia, Wallace Ann Whatley, Kate McWilliams, N Blayke Anderson, Lauren A Beretich","doi":"10.1016/j.tjnut.2025.01.027","DOIUrl":"10.1016/j.tjnut.2025.01.027","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Treatment with Metformin Significantly Reduces Senescent B Cells Present in the Adipose Tissue of People with Obesity","authors":"Maria Romero ,&nbsp;Andrew Gelsomini ,&nbsp;Kate Miller ,&nbsp;Dhananjay Suresh ,&nbsp;Seth Thaller ,&nbsp;Daniela Frasca","doi":"10.1016/j.tjnut.2024.10.013","DOIUrl":"10.1016/j.tjnut.2024.10.013","url":null,"abstract":"<div><h3>Background</h3><div>Our previous work has shown that senescent B cells accumulate in the human adipose tissue (AT) of people with obesity, where they express transcripts for markers associated with the senescence-associated secretory phenotype (SASP) and secrete multiple inflammatory mediators. These functions of AT-derived B cells are metabolically supported.</div></div><div><h3>Objectives</h3><div>To show that Metformin (MET), a widely used hypoglycemic and antidiabetic drug, is able at least in vitro to decrease frequencies, secretory profile, and metabolic requirements of senescent B cells isolated from the AT of people with obesity.</div></div><div><h3>Methods</h3><div>We recruited adult females with obesity (<em>n =</em> 8, age 40 ± 2 y, BMI range: 33–42) undergoing breast reduction surgery, who donated their discarded subcutaneous AT. B cells from stromal vascular fractions isolated after collagenase digestion of the AT were evaluated after in vitro incubation with MET (1 mM × 10⁶ B cells) or with a control medium without MET for the following measures: expression of transcripts for SASP-associated markers (p16^INK4a and p21^CIP1/WAF1) measured by quantitative polymerase chain reaction (qPCR); secretion of inflammatory cytokines (TNF-α, IL-6, IFN-γ and IL-17A) measured by a Cytometric Bead Array); metabolic characteristics as identified by a glycolytic test and Seahorse technology, and by the expression of transcripts for glucose transporters and metabolic enzymes involved in glucose metabolic pathways, measured by qPCR. To examine differences between MET-treated compared with untreated groups, paired Student’s <em>t</em> tests (two-tailed) were employed.</div></div><div><h3>Results</h3><div>MET in vitro was able to reduce frequencies and numbers of senescent B cells, as identified by staining with β-galactosidase, as well as the secretion of inflammatory cytokines, the expression of transcripts for <span>SASP</span>, and metabolic markers that support intrinsic B cell inflammation.</div></div><div><h3>Conclusions</h3><div>Our results provide evidence to support the beneficial effects of MET in reducing AT-related inflammation through its effects on senescent B cells.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 2","pages":"Pages 445-452"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega-3 Fatty Acids and Chronic Lung Diseases: A Narrative Review of Impacts from Womb to Tomb","authors":"Michael J Yaeger ,&nbsp;Laura Leuenberger ,&nbsp;Saame Raza Shaikh ,&nbsp;Kymberly M Gowdy","doi":"10.1016/j.tjnut.2024.10.028","DOIUrl":"10.1016/j.tjnut.2024.10.028","url":null,"abstract":"<div><div>The lungs are a mucosal organ constantly exposed to potentially harmful compounds and pathogens. Beyond their role in gas exchange, they must perform a well-orchestrated protective response against foreign invaders. The lungs identify these foreign compounds, respond to them by eliciting an inflammatory response, and restore tissue homeostasis after inflammation to ensure the lungs continue to function. In addition, lung function can be affected by genetics, environmental exposures, and age, leading to pulmonary diseases that infringe on quality of life. Recent studies indicate that diet can influence pulmonary health including the incidence and/or severity of lung diseases. Specifically, long-chain omega-3 polyunsaturated fatty acids (n-3 PUFAs) have gained attention because of their potential to reduce inflammation and promote resolution of inflammation. Docosahexaenoic acid and eicosapentaenoic acid are 2 potentially beneficial n-3 PUFAs primarily acquired through dietary intake. Here we review current literature examining the role of n-3 PUFAs and the biological mechanisms by which these fatty acids alter the incidence and pathologies of chronic lung diseases including asthma, chronic obstructive pulmonary disease, and interstitial lung disease. We also highlight the role of n-3 PUFAs in vulnerable populations such as pre/postnatal children, those with obesity, and the elderly. Lastly, we review the impact of n-3 PUFA intake and supplementation to evaluate if increasing consumption can mitigate mechanisms driving chronic lung diseases.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 2","pages":"Pages 453-464"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota-Focused Dietary Approaches to Support Health: A Systematic Review","authors":"Veronica K Hindle ,&nbsp;Nadine M Veasley ,&nbsp;Hannah D Holscher","doi":"10.1016/j.tjnut.2024.10.043","DOIUrl":"10.1016/j.tjnut.2024.10.043","url":null,"abstract":"<div><div>Diet affects the intestinal microbiota. Increasingly, research is linking the intestinal microbiota to various human health outcomes. Consumption of traditional prebiotics (inulin, fructo-oligosaccharides, and galacto-oligosaccharides) confers health benefits through substrate utilization by select intestinal microorganisms, namely <em>Bifidobacterium</em> and <em>Lactobacilli</em> spp. A similar but distinct concept focused on microorganisms to support human health is through direct consumption of certain live microorganisms recognized as probiotics, which classically include <em>Lactobacilli or Bifidobacterium</em> strains. With advances in sequencing technologies and culturing techniques, other novel functional intestinal microorganisms are being increasingly identified and studied to determine how they may underpin human health benefits. These novel microorganisms are targeted for enrichment within the autochthonous intestinal microbiota through dietary approaches and are also gaining interest as next-generation probiotics because of their purported beneficial properties. Thus, characterizing dietary approaches that nourish select microorganisms in situ is necessary to propel biotic-focused research forward. As such, we reviewed the literature to summarize findings on dietary approaches that nourish the human intestinal microbiota and benefit health to help fill the gap in knowledge on the connections between certain microorganisms, the metabolome, and host physiology. The overall objective of this systematic review was to summarize the impact of dietary interventions with the propensity to nourish certain intestinal bacteria, affect microbial metabolite concentrations, and support gastrointestinal, metabolic, and cognitive health in healthy adults. Findings from the 17 randomized controlled studies identified in this systematic review indicated that dietary interventions providing dietary fibers, phytonutrients, or unsaturated fatty acids differentially enriched <em>Akkermansia</em>, <em>Bacteroides</em>, <em>Clostridium</em>, <em>Eubacterium</em>, <em>Faecalibacterium</em>, <em>Roseburia</em>, and <em>Ruminococcus</em> species, with variable effects on microbial metabolites and subsequent associations with physiologic markers of gastrointestinal and metabolic health. These findings have implications for biotic-focused research on candidate prebiotic substrates as well as next-generation probiotics.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 2","pages":"Pages 381-401"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acceptability of Microbiota-Directed Complementary Foods in Treating Indian Children with Moderate Acute Malnutrition: eACT-MAM Pre-Proof-of-Concept Study","authors":"Sam Marconi ,&nbsp;Bireshwar Sinha ,&nbsp;Aditi Apte ,&nbsp;Midhun Sasikumar ,&nbsp;Gunjan Aggarwal ,&nbsp;Rashmi Chabukswar ,&nbsp;Akshaya Vasudevan ,&nbsp;Zavid Miyandad ,&nbsp;Sowndharya Pandian ,&nbsp;Pranita Shambharkar ,&nbsp;Himani Bhardwaj ,&nbsp;Girish Dayma ,&nbsp;Dhiraj Agarwal ,&nbsp;Sunita Taneja ,&nbsp;Venkata Raghava Mohan","doi":"10.1016/j.tjnut.2024.11.001","DOIUrl":"10.1016/j.tjnut.2024.11.001","url":null,"abstract":"<div><h3>Background</h3><div>In India, currently, there are no standard guidelines for the management of moderate acute malnutrition (MAM). Previous research in Bangladesh has shown that children with MAM have impaired gut microbiota development, and microbiota-directed complementary foods (MDCF) can potentially repair their gut microbiota.</div></div><div><h3>Objectives</h3><div>The objectives of this study were to evaluate the acceptability and safety of supplementing shelf-stable formulation of MDCF in Indian children with MAM as compared with a locally prepared ready-to-use supplementary food (RUSF) in 3 geographically distinct Indian populations and to establish and pilot systems of intervention delivery, collection, transport, and storage of stool samples using stringent protocols.</div></div><div><h3>Methods</h3><div>This pre-proof-of-concept (prePOC), multicentric, open-labeled, age-stratified, randomized controlled trial was done in children aged 6–18 mo with MAM. After a run-in period of 2 wk, the participants were supplemented with MDCF or RUSF for 4 wk through direct observation and followed up for another 2 wk post intervention. Maternal responses to the acceptability of the organoleptic properties of supplements were recorded weekly during the intervention phase of 4 wk. Compliance was reported based on the amount of supplement consumed by the children. Feasibility of weekly stool sample collection (except 7th week) within 30 min of passage was recorded. Anthropometric measurements were done at baseline and endline. Monitoring for adverse events was done throughout the course of the study.</div></div><div><h3>Results</h3><div>A total of 240 children with MAM were randomly selected to receive either MDCF or RUSF, of which 221 (92.1%) completed follow-up. The overall acceptability for &gt;80% of the maternal responses was reported as good or very good for all organoleptic properties in both MDCF and RUSF arms. MDCF and RUSF interventions had good-to-high compliance in 83.0% and 79.8% of participants, respectively. At the end of the intervention phase, 53.2% (58/109) of children in MDCF arm against 42.0% (47/112) in RUSF arm had weight-for-length <em>Z</em> score &gt;–2. The overall incidence of acute gastroenteritis reported was low; higher in MDCF compared with RUSF but not statistically significant.</div></div><div><h3>Conclusion</h3><div>The prePOC study demonstrates good acceptability and safety of MDCF among Indian children with MAM including the age group of 6–12 mo of age. The study demonstrates the feasibility of conducting a long-term supplementation study in this population.</div><div>The study was registered at the clinical trial registry of India as CTRI/2023/01/048716.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 2","pages":"Pages 612-620"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Mechanisms Underlying the Association Between the Profertility Diet and In Vitro Fertilization End Points","authors":"Robert B Hood ,&nbsp;Donghai Liang ,&nbsp;Yilin Wang ,&nbsp;Youran Tan ,&nbsp;Irene Souter ,&nbsp;Dean P Jones ,&nbsp;Russ Hauser ,&nbsp;Jorge E Chavarro ,&nbsp;Audrey J Gaskins","doi":"10.1016/j.tjnut.2024.11.013","DOIUrl":"10.1016/j.tjnut.2024.11.013","url":null,"abstract":"<div><h3>Background</h3><div>The profertility diet is a dietary pattern composed of nutrients and foods most consistently associated with in vitro fertilization (IVF) end points in women.</div></div><div><h3>Objectives</h3><div>We examined the potential biological mechanisms underlying the association between adherence to a profertility diet and IVF end points using high-resolution metabolomics.</div></div><div><h3>Methods</h3><div>Among 120 women who underwent an autologous oocyte IVF cycle (2007–2015) in Northeast United States, we collected a serum sample during controlled ovarian stimulation and a follicular fluid sample on the day of oocyte retrieval. Women completed a food frequency questionnaire upon enrollment into the study to examine adherence to the profertility diet pattern. Liquid chromatography with high-resolution mass spectrometry was used for untargeted metabolomic analysis of biospecimens. We identified metabolic features (and enriched biological pathways) associated with the profertility diet and 2 IVF end points, live birth and clinical pregnancy, via a meet-in-the-middle approach.</div></div><div><h3>Results</h3><div>In the follicular fluid metabolome, vitamin D-3 metabolism was associated with adherence to the profertility diet pattern and live birth. Additionally, vitamin D-3 metabolism, vitamin B-6 metabolism, and bile acid biosynthesis were associated with both adherence to the profertility diet pattern and clinical pregnancy. In the serum metabolome, only tryptophan metabolism was associated with adherence to the profertility diet pattern and live birth. We confirmed the chemical identity of a metabolite with level 1 evidence, 4-pyridoxate, which was higher in the serum and follicular fluid among women with stronger adherence to the profertility diet pattern and among women with a live birth.</div></div><div><h3>Conclusions</h3><div>The beneficial association between adherence to the profertility diet and IVF outcomes may be mediated through vitamin D-3 metabolism, vitamin B-6 metabolism, and bile acid biosynthesis in the follicular fluid and tryptophan metabolism in the serum. These results provide new insight in the important biological pathways underlying a dietary pattern providing optimal fertility benefits to women.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 2","pages":"Pages 559-569"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Alcohol Consumption and Physical Exercise on Overweight and Gut Microbiota Deserves Attention","authors":"Shengxia Lv ,&nbsp;Yike Wang ,&nbsp;Linghui Tao,&nbsp;Yongsheng Zhang","doi":"10.1016/j.tjnut.2024.05.031","DOIUrl":"10.1016/j.tjnut.2024.05.031","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 2","pages":"Pages 655-656"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiologic Risk and Prevention and Interventions in Parkinson Disease: From a Nutrition-Based Perspective.","authors":"Fan Zhang, Yu-Xian Liu, Yun-Yue Zhu, Qiu-Yan Yu, Samwel Sylvester Msigwa, Zhi-Hai Zeng, Xiong Zhang, Hong-Mei Wu, Jian-Hong Zhu","doi":"10.1016/j.tjnut.2025.01.028","DOIUrl":"10.1016/j.tjnut.2025.01.028","url":null,"abstract":"<p><p>Parkinson disease (PD) is a prevalent neurodegenerative disorder associated with aging. Current treatments for PD primarily focus on alleviating symptoms rather than altering the progression of the disease. The sporadic form of PD, which accounts for most cases, is thought to arise from a complex interaction between genetic predispositions and environmental factors. This review aimed to examine epidemiologic evidence regarding nutrition-related exposure factors and their associations with risk of developing PD. We proposed a tentative conclusion for each factor based on the available evidence. These associations may vary by gender and depend on dietary intake patterns and adherence. We also reviewed clinical trials on nutrition-related interventions for PD symptoms and progression. Future clinical trials may benefit from combining nutrition factors in intervention and testing within single-gender cohorts or subgroups defined by epidemiologic outcomes.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Inequities in Adequacy of Micronutrient Intakes in Rural Bangladesh","authors":"Phuong Hong Nguyen ,&nbsp;Masum Ali ,&nbsp;Julie Ghostlaw ,&nbsp;Lan Mai Tran ,&nbsp;Aklima Parvin ,&nbsp;M Mehrab Bakhtiar ,&nbsp;Akhter U Ahmed","doi":"10.1016/j.tjnut.2024.11.018","DOIUrl":"10.1016/j.tjnut.2024.11.018","url":null,"abstract":"<div><h3>Background</h3><div>Micronutrient deficiencies pose a significant public health challenge, yet limited evidence exists on micronutrient intakes over time in Bangladesh.</div></div><div><h3>Objectives</h3><div>We assessed trends and adequacies in micronutrient intakes and examined the changes in inequities by age group, sex, and expenditure quintile.</div></div><div><h3>Methods</h3><div>We used panel data from the 2011 and 2018 Bangladesh Integrated Household Survey (<em>n</em> = 21,475 and 21,589 household members aged 2 y or older, respectively). Food consumption data were collected using a household dietary recall. Changes in micronutrient intakes were assessed using nonparametric Mann–Whitney–Wilcoxon rank sum test. Inequities in outcomes were examined using the slope index of inequality and concentration index.</div></div><div><h3>Results</h3><div>Micronutrient intakes remained suboptimal across 2011 and 2018, with low adequacy (&lt;0.50) for all nutrients except niacin. While vitamin A intake increased across various demographics, trends for other micronutrient intakes differed by age. Intakes improved for 10 micronutrients among children aged 2 to &lt;5 y but increased for only half of the examined micronutrients among children aged 5–9 y. For adolescents and adults, most micronutrient intakes slightly declined, with greater inadequacies observed among females than those among males. Pregnant women experienced sharper declines in adequacy of micronutrient intakes than lactating women. The mean probability of adequacy (MPA) was low (around one-third) for all age groups with lower MPA among poorer than that among richer households across age, sex, and survey years. Inequity gaps in MPA mostly declined, except for females aged 50 y or older and pregnant women.</div></div><div><h3>Conclusions</h3><div>Micronutrient intakes and adequacies remain suboptimal and have decreased marginally over time for many nutrients and MPA across most age groups. Inequities in micronutrient intakes persist by age, sex, and income levels, disproportionately affecting the poor, adults, and women. Our study calls for evidence-based policies and programs that incorporate a range of proven approaches and tailored solutions to effectively tackle persisting inequities and ensure access to healthy diets for all.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 2","pages":"Pages 492-508"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}