Pub Date : 2020-01-25DOI: 10.7897/2277-4572.091165
S. Anand, Ajantha, S. ShashirekhaK, Geetha Nayak
{"title":"AN OBSERVATIONAL EXPERIMENTAL ASSESSMENT OF ANTIBACTERIAL ACTIVITY OF GUDUCHI AGAINST KLEBSIELLA PNEUMONIAE BY URINE CULTURE AND SENSITIVITY IN PITTAJAMUTRAKRICHRA (URINARY TRACT INFECTION)","authors":"S. Anand, Ajantha, S. ShashirekhaK, Geetha Nayak","doi":"10.7897/2277-4572.091165","DOIUrl":"https://doi.org/10.7897/2277-4572.091165","url":null,"abstract":"","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"84 1","pages":"31-38"},"PeriodicalIF":0.0,"publicationDate":"2020-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90518217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-10DOI: 10.7897/2277-4572.085153
Binitha Raj Rv, S. Mahadevan, Rosa Mp, R. Ks
Introduction: Shilajit (Black bitumen: Asphaltum punjabinum) is an important herbo-mineral drug in Ayurvedic system of medicine. It is a blackish brown exudate which oozes out from sedimentary mountain rocks. Due to its high cost, increased demand and difficulty in getting pure forms, adulteration of shilajit is common in raw drug industry. So quality control parameters are necessary to scrutinize genuine shilajit. Objectives: The present work aims to develop simple quality control parameters of shilajit in terms of physicochemical properties and HPTLC (High Performance Thin Layer Chromatography) fingerprinting. Materials & Methods: Microscopic evaluation, flame test and organoleptic evaluation of shilajit were done to confirm the identity. Physico-chemical parameters such as specific gravity, pH, refractive index, loss on drying, total ash, acid-insoluble ash, solubility, fluorescence analysis and qualitative analysis were carried out. Moreover, HPTLC fingerprint was developed using Camag HPTLC instrument and detected its presence in a pharmaceutical preparation. Results: Physico-chemical parameters of shilajit were established and HPTLC chromatogram was developed with hydro-alcoholic extract of shilajit using the mobile phase Toluene: Ethyl acetate. This HPTLC method was also proved successful in confirming its presence in Chandraprabha gudika. Conclusion: The present study on identification, physico-chemical evaluation and HPTLC fingerprinting of shilajit provides useful information regarding quality control parameters and identifying parameters to substantiate and authenticate the drug and could be used for comparison of market samples to ensure its genuineness. A simple, specific and accurate HPTLC method was validated for its fingerprint analysis and detection in a pharmaceutical preparation, Chandraprabha gudika.
{"title":"HPTLC FINGERPRINTING ANALYSIS OF SHILAJIT: AN AYURVEDIC HERBO-MINERAL DRUG","authors":"Binitha Raj Rv, S. Mahadevan, Rosa Mp, R. Ks","doi":"10.7897/2277-4572.085153","DOIUrl":"https://doi.org/10.7897/2277-4572.085153","url":null,"abstract":"Introduction: Shilajit (Black bitumen: Asphaltum punjabinum) is an important herbo-mineral drug in Ayurvedic system of medicine. It is a blackish brown exudate which oozes out from sedimentary mountain rocks. Due to its high cost, increased demand and difficulty in getting pure forms, adulteration of shilajit is common in raw drug industry. So quality control parameters are necessary to scrutinize genuine shilajit. Objectives: The present work aims to develop simple quality control parameters of shilajit in terms of physicochemical properties and HPTLC (High Performance Thin Layer Chromatography) fingerprinting. Materials & Methods: Microscopic evaluation, flame test and organoleptic evaluation of shilajit were done to confirm the identity. Physico-chemical parameters such as specific gravity, pH, refractive index, loss on drying, total ash, acid-insoluble ash, solubility, fluorescence analysis and qualitative analysis were carried out. Moreover, HPTLC fingerprint was developed using Camag HPTLC instrument and detected its presence in a pharmaceutical preparation. Results: Physico-chemical parameters of shilajit were established and HPTLC chromatogram was developed with hydro-alcoholic extract of shilajit using the mobile phase Toluene: Ethyl acetate. This HPTLC method was also proved successful in confirming its presence in Chandraprabha gudika. Conclusion: The present study on identification, physico-chemical evaluation and HPTLC fingerprinting of shilajit provides useful information regarding quality control parameters and identifying parameters to substantiate and authenticate the drug and could be used for comparison of market samples to ensure its genuineness. A simple, specific and accurate HPTLC method was validated for its fingerprint analysis and detection in a pharmaceutical preparation, Chandraprabha gudika.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"329 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76567101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-10DOI: 10.7897/2277-4572.085150
S. Raj, Shivakumar
Madhumeha is disease known to the mankind as ‘honey urine, sweet urine’ since ancient times and maximum number of srotas (channels) are included in the manifestation of disease which is nearest clinical entity for diabetes mellitus. Diabetes Mellitus is a major non communicable disease with increasing prevalence at global level. Diabetes Mellitus is characterized mainly by hyperglycemia due to absolute or relative deficiency of insulin. Food habits are the major cause of Diabetes Mellitus and emerged as an public health problem globally. Ayurveda has given prime importance for the protection of health of healthy individual which is possible by preventing disease by promoting health. Ayurveda has laid down all preventive principle under Swasthyarakshana in which pathya literally means a way or channel it also said that beneficial for patient which fasten the process of recovery from the diseased state. Ayurveda mention pathya as treatment. Hence ayurvedic dietetics (Pathyahara) is a fundamental intervention strategy for Diabetes Mellitus.
{"title":"ROLE OF AYURVEDA DIETETICS IN THE MANAGEMENT OF MADHUMEHA (DIABETES MELLITUS): A REVIEW","authors":"S. Raj, Shivakumar","doi":"10.7897/2277-4572.085150","DOIUrl":"https://doi.org/10.7897/2277-4572.085150","url":null,"abstract":"Madhumeha is disease known to the mankind as ‘honey urine, sweet urine’ since ancient times and maximum number of srotas (channels) are included in the manifestation of disease which is nearest clinical entity for diabetes mellitus. Diabetes Mellitus is a major non communicable disease with increasing prevalence at global level. Diabetes Mellitus is characterized mainly by hyperglycemia due to absolute or relative deficiency of insulin. Food habits are the major cause of Diabetes Mellitus and emerged as an public health problem globally. Ayurveda has given prime importance for the protection of health of healthy individual which is possible by preventing disease by promoting health. Ayurveda has laid down all preventive principle under Swasthyarakshana in which pathya literally means a way or channel it also said that beneficial for patient which fasten the process of recovery from the diseased state. Ayurveda mention pathya as treatment. Hence ayurvedic dietetics (Pathyahara) is a fundamental intervention strategy for Diabetes Mellitus.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80486614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-10DOI: 10.7897/2277-4572.085154
A. A. A. Abdusalam, Gazala Mohamed Ben hander
{"title":"VIRTUAL SCREENING FOR IDENTIFICATION OF POTENT ANTI-ASTHMATIC COMPOUNDS EXTRACTED FROM THYME PLANT: IN-SILICO APPROACH","authors":"A. A. A. Abdusalam, Gazala Mohamed Ben hander","doi":"10.7897/2277-4572.085154","DOIUrl":"https://doi.org/10.7897/2277-4572.085154","url":null,"abstract":"","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81888112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-10DOI: 10.7897/2277-4572.085149
B. Anuradha, Ajantha, S GeethaNayak, Anjana
Ayurveda emphasizes agni-vaishamya as a cause of manifestation of vyadhi (disease). The undigested food due to vitiated agni results in apakwa-ahara-rasa, that does not get absorbed and transformed is termed as ama, is said to be root cause for diseases. Ama combines with dosha to form amadosha that acquires more shuktatva, further forming amavisha, paving to varied manifestations in diseases. Therefore, analyzing saama and niramavastha is essential for better diagnosis and management. Amlapitta, one among the annavaha-sroto-vikara manifests due to agni-vaishamya. Jihwa pareeksha (tongue examination) plays an important role to assess various changes in jihwa. It reflects the status of annavaha-srotas and ama. Thus, the present study aims at observation of manifestations on jihwa (tongue) by jihwa pareeksha in saama avastha of Amlapitta. Patients of Amlapitta were screened and subjected for jihwa pareeksha. Diagnosis of Amlapitta assessed by samanya lakshanas of Amlapitta and their saama avastha was evaluated by samanya lakshanas of Ama. From study, it is concluded that the manifestations elicited by jihwa pareeksha can be utilized for assessment of saama avastha in Amlapitta by clinical examination.
{"title":"JIHWA PAREEKSHA IN SAAMA AVASTHA OF AMLAPITTA: A CLINICAL STUDY","authors":"B. Anuradha, Ajantha, S GeethaNayak, Anjana","doi":"10.7897/2277-4572.085149","DOIUrl":"https://doi.org/10.7897/2277-4572.085149","url":null,"abstract":"Ayurveda emphasizes agni-vaishamya as a cause of manifestation of vyadhi (disease). The undigested food due to vitiated agni results in apakwa-ahara-rasa, that does not get absorbed and transformed is termed as ama, is said to be root cause for diseases. Ama combines with dosha to form amadosha that acquires more shuktatva, further forming amavisha, paving to varied manifestations in diseases. Therefore, analyzing saama and niramavastha is essential for better diagnosis and management. Amlapitta, one among the annavaha-sroto-vikara manifests due to agni-vaishamya. Jihwa pareeksha (tongue examination) plays an important role to assess various changes in jihwa. It reflects the status of annavaha-srotas and ama. Thus, the present study aims at observation of manifestations on jihwa (tongue) by jihwa pareeksha in saama avastha of Amlapitta. Patients of Amlapitta were screened and subjected for jihwa pareeksha. Diagnosis of Amlapitta assessed by samanya lakshanas of Amlapitta and their saama avastha was evaluated by samanya lakshanas of Ama. From study, it is concluded that the manifestations elicited by jihwa pareeksha can be utilized for assessment of saama avastha in Amlapitta by clinical examination.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"129 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73431135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-10DOI: 10.7897/2277-4572.085152
S. Bhusari, S. Waghmare, P. Wakte
The present research work demonstrates an analytical method development for simultaneous estimation of Rifampicin (RIF) and its bioenhancer; 3’,5dihydroxyflavone-7-O-β-D-galacturonide-4’-O-β-D-glucopyranoside (CC-I) in combined dosage form using Q-absorbance ratio concept. While method development, two different wavelengths one representing Iso-absorptive point (370 nm) and other representing the λmax of Rifampicin (239 nm) were used. Optimum response was obtained in solvent system that comprises methanol and water in ratio of 80:20 v/v. Proposed UV method was found to be linear over the concentration range of 2-20 μg/ml for Rifampicin and that of 1-24 μg/ml for CC-I. On the basis of recovery studies after standard addition, accuracy of proposed method was found to be in between 99.94 to 100.30 and 99.90 to 99.96 % for RIF and CC-I respectively. Intra-day precision of the method in terms of % relative standard deviation was found to be in between 0.21 to 1.36 and 0.21 to 1.77 for RIF and CC-I respectively. Inter-day precision range of the method for RIF and CC-I was found to be in between 0.13 to 1.94 and 0.11 to 1.58 respectively. LOD and LOQ of proposed UV method were 0.043 and 0.014 μg/ml for RIF and 0.37 and 0.12 μg/ml for CC-I. Proposed UV method was robust and rugged in nature. Proposed method was successfully used for the estimation of RIF and CC-I contents of in-house formulation consisting of APIs and the common excipients.
{"title":"DEVELOPMENT AND VALIDATION OF Q-ABSORBANCE RATIO SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF RIFAMPICIN AND ITS BIOENHANCER; 3, 5'-DIHYDROXYFLAVONE-7-O-B-D-GALACTURONIDE-4'-O-B-D-GLUCOPYRANOSIDE; IN BULK AND FORMULATION","authors":"S. Bhusari, S. Waghmare, P. Wakte","doi":"10.7897/2277-4572.085152","DOIUrl":"https://doi.org/10.7897/2277-4572.085152","url":null,"abstract":"The present research work demonstrates an analytical method development for simultaneous estimation of Rifampicin (RIF) and its bioenhancer; 3’,5dihydroxyflavone-7-O-β-D-galacturonide-4’-O-β-D-glucopyranoside (CC-I) in combined dosage form using Q-absorbance ratio concept. While method development, two different wavelengths one representing Iso-absorptive point (370 nm) and other representing the λmax of Rifampicin (239 nm) were used. Optimum response was obtained in solvent system that comprises methanol and water in ratio of 80:20 v/v. Proposed UV method was found to be linear over the concentration range of 2-20 μg/ml for Rifampicin and that of 1-24 μg/ml for CC-I. On the basis of recovery studies after standard addition, accuracy of proposed method was found to be in between 99.94 to 100.30 and 99.90 to 99.96 % for RIF and CC-I respectively. Intra-day precision of the method in terms of % relative standard deviation was found to be in between 0.21 to 1.36 and 0.21 to 1.77 for RIF and CC-I respectively. Inter-day precision range of the method for RIF and CC-I was found to be in between 0.13 to 1.94 and 0.11 to 1.58 respectively. LOD and LOQ of proposed UV method were 0.043 and 0.014 μg/ml for RIF and 0.37 and 0.12 μg/ml for CC-I. Proposed UV method was robust and rugged in nature. Proposed method was successfully used for the estimation of RIF and CC-I contents of in-house formulation consisting of APIs and the common excipients.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84001097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-10DOI: 10.7897/2277-4572.085148
S. Anand, Ajantha, S ShashirekhaK, B. Anuradha
{"title":"A COMPARATIVE STUDY TO EVALUATE EFFICACY OF GOKSHURA AND GUDUCHI AGAINST KLEBSIELLA PNEUMONIAE BY URINE CULTURE AND SENSITIVITY IN PITTAJA MUTRAKRICHRA (URINARY TRACT INFECTION)","authors":"S. Anand, Ajantha, S ShashirekhaK, B. Anuradha","doi":"10.7897/2277-4572.085148","DOIUrl":"https://doi.org/10.7897/2277-4572.085148","url":null,"abstract":"","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84206251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-10DOI: 10.7897/2277-4572.085151
Aparajita Das, T. Tripathy
Obesity is the common non communicable disease which is major public problem of 21th century. Obesity increase the other various diseases like type 2 Diabetes mellitus, Heart disease, certain type of cancer, sleep apnoea and osteoarthritis. In 2016 more than 1.9 billion adults aged 18 and older were overweight of which over 650 million were obese. This represents about 39% of adults with overweight and 13% of them obese. Considering the disease burden in India, according to National Family Health Survey 2007 it was estimated that 12.1 % of males and 16% of females were overweight or obese and in Karnataka it was 14% of males and 17.3% of females. Obesity one among lifestyle disorder hence proper ahara, vihara is essential in order to prevent it. In Ayurveda ahara (food) is mentioned as one among the trayauapastambha (three sub pillars of life) which supports the body. So food plays a major role to preventing diseases like obesity. Along with ahara improper vihara (life style) also plays a major role in incidence of obesity. Now a days due to sedentary lifestyle during domestic and occupational activities leading to lifestyle disorders like Obesity. So it is importance to stress on lifestyle modification. Present study highlights on role of diet and lifestyle modification in Obesity.
{"title":"PREVENTION OF STHOULYA (OBESITY) WITH AHARA AND VIHARA: A REVIEW","authors":"Aparajita Das, T. Tripathy","doi":"10.7897/2277-4572.085151","DOIUrl":"https://doi.org/10.7897/2277-4572.085151","url":null,"abstract":"Obesity is the common non communicable disease which is major public problem of 21th century. Obesity increase the other various diseases like type 2 Diabetes mellitus, Heart disease, certain type of cancer, sleep apnoea and osteoarthritis. In 2016 more than 1.9 billion adults aged 18 and older were overweight of which over 650 million were obese. This represents about 39% of adults with overweight and 13% of them obese. Considering the disease burden in India, according to National Family Health Survey 2007 it was estimated that 12.1 % of males and 16% of females were overweight or obese and in Karnataka it was 14% of males and 17.3% of females. Obesity one among lifestyle disorder hence proper ahara, vihara is essential in order to prevent it. In Ayurveda ahara (food) is mentioned as one among the trayauapastambha (three sub pillars of life) which supports the body. So food plays a major role to preventing diseases like obesity. Along with ahara improper vihara (life style) also plays a major role in incidence of obesity. Now a days due to sedentary lifestyle during domestic and occupational activities leading to lifestyle disorders like Obesity. So it is importance to stress on lifestyle modification. Present study highlights on role of diet and lifestyle modification in Obesity.","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90149949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-20DOI: 10.7897/2277-4572.084141
M AshithaSaffrin, R. Sureshkumar
{"title":"AN OVERVIEW ON HERBAL SUNSCREEN FORMULATION AND SUN PROTECTION FACTOR VALUE","authors":"M AshithaSaffrin, R. Sureshkumar","doi":"10.7897/2277-4572.084141","DOIUrl":"https://doi.org/10.7897/2277-4572.084141","url":null,"abstract":"","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73845865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-07-20DOI: 10.7897/2277-4572.084146
A. Joshi, Rashmi Pujar, Pallavi Mullimani, A. Haridas
{"title":"CRITICAL REVIEW ON RASAOUSHADI IN GERIATRICS WITH SPECIAL REFERENCE TO DEMENTIA","authors":"A. Joshi, Rashmi Pujar, Pallavi Mullimani, A. Haridas","doi":"10.7897/2277-4572.084146","DOIUrl":"https://doi.org/10.7897/2277-4572.084146","url":null,"abstract":"","PeriodicalId":16738,"journal":{"name":"Journal of Pharmaceutical and Scientific Innovation","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85942897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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