Journal of psychiatric research最新文献_第9页

Self-regulation in adults with intermittent explosive disorder and a history of suicide attempts

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-02-01 DOI: 10.1016/j.jpsychires.2025.01.058

Matthew A. Timmins , So Yu Cicy Ng , Emil F. Coccaro

Both suicide attempts and aggression aim to cause harm and are associated with numerous personal and societal consequences but differ on intended targets. Aggression towards others is associated with increased risk of suicidal behavior. Research has demonstrated commonalities with impulsiveness and affect regulation for both. This study's purpose was to compare self-regulation between those meeting criteria for a psychiatric condition characterized by unplanned aggression (intermittent explosive disorder [IED]), a lifetime history of a suicide attempt (SA), and those with both (IED + SA), as well as compared to participants meeting criteria for non-aggressive psychopathology (PC) or no psychiatric disorder (HC). Adult community participants (n = 735) completed diagnostic assessments and self-report measures on suicidal behaviors, aggression, trait anger, impulsivity, and affect regulation as part of a larger aggression research program. Pairwise comparisons found IED + SA was associated with the highest scores on all outcome variables except compared to IED on anger. IED had higher aggression and anger scores than SA but did not differ on general impulsivity and affect regulation scores. PC did not differ from SA on anger or from IED and SA on affect regulation; PC scored lower on aggression and anger than IED + SA and IED. HC scored lowest on all variables. Such results imply IED with past suicidal behavior may be associated with heightened self-regulation difficulties overall compared to IED alone and non-aggressive psychopathology. Future research may build upon this by further recruiting for both unplanned aggression and suicidal behavior, as well as including comparisons with other impulsivity-related diagnoses.

{"title":"Self-regulation in adults with intermittent explosive disorder and a history of suicide attempts","authors":"Matthew A. Timmins , So Yu Cicy Ng , Emil F. Coccaro","doi":"10.1016/j.jpsychires.2025.01.058","DOIUrl":"10.1016/j.jpsychires.2025.01.058","url":null,"abstract":"<div><div>Both suicide attempts and aggression aim to cause harm and are associated with numerous personal and societal consequences but differ on intended targets. Aggression towards others is associated with increased risk of suicidal behavior. Research has demonstrated commonalities with impulsiveness and affect regulation for both. This study's purpose was to compare self-regulation between those meeting criteria for a psychiatric condition characterized by unplanned aggression (intermittent explosive disorder [IED]), a lifetime history of a suicide attempt (SA), and those with both (IED + SA), as well as compared to participants meeting criteria for non-aggressive psychopathology (PC) or no psychiatric disorder (HC). Adult community participants (<em>n</em> = 735) completed diagnostic assessments and self-report measures on suicidal behaviors, aggression, trait anger, impulsivity, and affect regulation as part of a larger aggression research program. Pairwise comparisons found IED + SA was associated with the highest scores on all outcome variables except compared to IED on anger. IED had higher aggression and anger scores than SA but did not differ on general impulsivity and affect regulation scores. PC did not differ from SA on anger or from IED and SA on affect regulation; PC scored lower on aggression and anger than IED + SA and IED. HC scored lowest on all variables. Such results imply IED with past suicidal behavior may be associated with heightened self-regulation difficulties overall compared to IED alone and non-aggressive psychopathology. Future research may build upon this by further recruiting for both unplanned aggression and suicidal behavior, as well as including comparisons with other impulsivity-related diagnoses.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"182 ","pages":"Pages 530-536"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143138303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insomnia patients have a poor intestinal prognosis: Accompanied by microbiota-derived short chain fatty acids, diet and zonulin

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-01-31 DOI: 10.1016/j.jpsychires.2025.01.035

Fatma Hümeyra Yerlikaya , Duygu Eryavuz Onmaz , Yavuz Selvi , Mustafa Topkafa , Abdullah Sivrikaya , Samet Kaya , Fadime Akdağ

Background

It is becoming increasingly clear that the relationship between sleep disturbance and gut microbiota metabolites is of great importance.

Aims

This study aimed to examine the changes in microbiota metabolites, brain-derived neurotrophic factors and synaptic proteins in insomnia patients, with a particular focus on the impact of diet.

Methods

A total of 41 patients with insomnia and 45 healthy individuals participated in the study. The Food Frequency Questionnaire was employed to ascertain the subjects' daily macronutrient intake over the previous month. Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) were used to evaluate insomnia complaints. The concentration of faecal short-chain fatty acids (SCFAs) was quantified by gas chromatography. Serum zonulin, brain derived neurotrophic factor (BDNF), postsynaptic density protein 95 (PSD-95) and synaptophysin-like protein 1 (SYPL1) protein levels were quantified using an enzyme-linked immunosorbent assay (ELISA) method.

Results

The total SCFAs, acetic acid, propionic acid, butyric acid and valeric acid levels were found to be significantly lower in the insomnia patient group compared to the control group. The levels of zonulin, PSD-95 and SYPL1 were found to be significantly elevated in the insomnia patient group in comparison to the control group. A significant negative correlation was observed between PSQI and ISI values and fatty acids.

Conclusions

It has been demonstrated that sleep deprivation may be associated with alterations in the metabolites produced by the gut microbiota. In Western countries where dietary fibre consumption is low, increasing SCFA levels, promoting gut integrity and homeostasis may be regarded as a promising new approach for the treatment of diseases such as insomnia.

{"title":"Insomnia patients have a poor intestinal prognosis: Accompanied by microbiota-derived short chain fatty acids, diet and zonulin","authors":"Fatma Hümeyra Yerlikaya , Duygu Eryavuz Onmaz , Yavuz Selvi , Mustafa Topkafa , Abdullah Sivrikaya , Samet Kaya , Fadime Akdağ","doi":"10.1016/j.jpsychires.2025.01.035","DOIUrl":"10.1016/j.jpsychires.2025.01.035","url":null,"abstract":"<div><h3>Background</h3><div>It is becoming increasingly clear that the relationship between sleep disturbance and gut microbiota metabolites is of great importance.</div></div><div><h3>Aims</h3><div>This study aimed to examine the changes in microbiota metabolites, brain-derived neurotrophic factors and synaptic proteins in insomnia patients, with a particular focus on the impact of diet.</div></div><div><h3>Methods</h3><div>A total of 41 patients with insomnia and 45 healthy individuals participated in the study. The Food Frequency Questionnaire was employed to ascertain the subjects' daily macronutrient intake over the previous month. Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index (ISI) were used to evaluate insomnia complaints. The concentration of faecal short-chain fatty acids (SCFAs) was quantified by gas chromatography. Serum zonulin, brain derived neurotrophic factor (BDNF), postsynaptic density protein 95 (PSD-95) and synaptophysin-like protein 1 (SYPL1) protein levels were quantified using an enzyme-linked immunosorbent assay (ELISA) method.</div></div><div><h3>Results</h3><div>The total SCFAs, acetic acid, propionic acid, butyric acid and valeric acid levels were found to be significantly lower in the insomnia patient group compared to the control group. The levels of zonulin, PSD-95 and SYPL1 were found to be significantly elevated in the insomnia patient group in comparison to the control group. A significant negative correlation was observed between PSQI and ISI values and fatty acids.</div></div><div><h3>Conclusions</h3><div>It has been demonstrated that sleep deprivation may be associated with alterations in the metabolites produced by the gut microbiota. In Western countries where dietary fibre consumption is low, increasing SCFA levels, promoting gut integrity and homeostasis may be regarded as a promising new approach for the treatment of diseases such as insomnia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 25-30"},"PeriodicalIF":3.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143351018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical heterogeneity in major depressive disorder underlies comorbidity with functional disorders

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-01-31 DOI: 10.1016/j.jpsychires.2025.01.056

Nathaniel S. Thomas , Nathan A. Gillespie , Michael C. Neale , Judith G.M. Rosmalen , Hanna M. van Loo , Kenneth S. Kendler

The comorbidities between MDD and functional disorders (FDs), such as fibromyalgia (FM), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and irritable bowel syndrome (IBS) remain largely unexplored. We analyzed data from 10,563 lifetime MDD cases (mean age = 50.5 (SD = 11.9), 71.8% female) from the Lifelines Cohort Study. Lifetime MDD symptoms from DSM-5 criterion A were assessed in 2018. Current FDs were assessed according to diagnostic criteria between 2014 and 2017. First, we modeled the effect of 12 disaggregated MDD symptoms on FM, ME/CFS, and IBS diagnoses using multiple logistic regression. Most, but not all, MDD symptoms were associated with FD diagnoses, suggesting that some features of MDD are particularly important to the comorbidity between MDD and FDs. Next, we used Latent Class Analysis to classify MDD cases based on their symptoms to explore whether MDD – FD comorbidities were associated with specific symptom profiles. We found that a five-class solution provided the best balance of model fit and entropy. Two classes, termed severe typical and anhedonia/weight gain, associated with increased prevalence of all FDs. The severe typical class was equally associated with FM and ME/CFS, while the anhedonia/weight gain class was differentially associated with pairs of FDs suggesting that features of the anhedonia/weight gain class are uniquely related to different FDs with varying magnitudes of effect and, possibly, different mechanisms. The comorbidity between MDD and FDs does not appear to result from a single mechanism. Identification of the mechanisms that underlie the association between MDD and FDs is a priority for future work.

{"title":"Clinical heterogeneity in major depressive disorder underlies comorbidity with functional disorders","authors":"Nathaniel S. Thomas , Nathan A. Gillespie , Michael C. Neale , Judith G.M. Rosmalen , Hanna M. van Loo , Kenneth S. Kendler","doi":"10.1016/j.jpsychires.2025.01.056","DOIUrl":"10.1016/j.jpsychires.2025.01.056","url":null,"abstract":"<div><div>The comorbidities between MDD and functional disorders (FDs), such as fibromyalgia (FM), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and irritable bowel syndrome (IBS) remain largely unexplored. We analyzed data from 10,563 lifetime MDD cases (mean age = 50.5 (SD = 11.9), 71.8% female) from the Lifelines Cohort Study. Lifetime MDD symptoms from DSM-5 criterion A were assessed in 2018. Current FDs were assessed according to diagnostic criteria between 2014 and 2017. First, we modeled the effect of 12 disaggregated MDD symptoms on FM, ME/CFS, and IBS diagnoses using multiple logistic regression. Most, but not all, MDD symptoms were associated with FD diagnoses, suggesting that some features of MDD are particularly important to the comorbidity between MDD and FDs. Next, we used Latent Class Analysis to classify MDD cases based on their symptoms to explore whether MDD – FD comorbidities were associated with specific symptom profiles. We found that a five-class solution provided the best balance of model fit and entropy. Two classes, termed <em>severe typical</em> and <em>anhedonia/weight gain,</em> associated with increased prevalence of all FDs. The severe typical class was equally associated with FM and ME/CFS, while the anhedonia/weight gain class was differentially associated with pairs of FDs suggesting that features of the anhedonia/weight gain class are uniquely related to different FDs with varying magnitudes of effect and, possibly, different mechanisms. The comorbidity between MDD and FDs does not appear to result from a single mechanism. Identification of the mechanisms that underlie the association between MDD and FDs is a priority for future work.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 16-24"},"PeriodicalIF":3.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143351017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of feeling understood in men's loneliness-depression pathway: Longitudinal findings over three assessment waves

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-01-31 DOI: 10.1016/j.jpsychires.2025.01.057

Matthew C. Genuchi , John S. Ogrodniczuk , John L. Oliffe , Andreas Walther , David Kealy , Simon M. Rice , Zac E. Seidler

Introduction

Loneliness is a significant global public health issue associated with a range of negative health outcomes. Men experiencing loneliness are at increased risk for depression; however, limited research has focused on mechanisms that explain the relationship between men's loneliness and depression. Existential isolation, the lack of feeling deeply understood by others, may be an important element that provides insight into how loneliness is related to men's depression over time, as evidence suggests that masculine norms may impair men's abilities to seek out help and experience emotional intimacy. The purpose of this study was to examine existential isolation as mediator between men's loneliness and depression over time. We hypothesized that the relationship between men's baseline loneliness and depression six months later would be mediated by their sense of feeling understood at three months.

Materials and methods

An international community sample of men (n = 300) were recruited from the men's mental health website HeadsUpGuys and completed anonymous online surveys at three time points, including baseline, three months, and six months. The longitudinal design involved self-reported assessment of participants' loneliness, sense of feeling deeply understood, and depressive symptoms at all timepoints.

Results

The mediation model revealed men's perception of feeling deeply understood by others to be a significant temporal mediator of the association between loneliness and depression.

Conclusions

Interventions that reduce or prevent men's loneliness and existential isolation may significantly reduce men's depression risk.

{"title":"The role of feeling understood in men's loneliness-depression pathway: Longitudinal findings over three assessment waves","authors":"Matthew C. Genuchi , John S. Ogrodniczuk , John L. Oliffe , Andreas Walther , David Kealy , Simon M. Rice , Zac E. Seidler","doi":"10.1016/j.jpsychires.2025.01.057","DOIUrl":"10.1016/j.jpsychires.2025.01.057","url":null,"abstract":"<div><h3>Introduction</h3><div>Loneliness is a significant global public health issue associated with a range of negative health outcomes. Men experiencing loneliness are at increased risk for depression; however, limited research has focused on mechanisms that explain the relationship between men's loneliness and depression. Existential isolation, the lack of feeling deeply understood by others, may be an important element that provides insight into how loneliness is related to men's depression over time, as evidence suggests that masculine norms may impair men's abilities to seek out help and experience emotional intimacy. The purpose of this study was to examine existential isolation as mediator between men's loneliness and depression over time. We hypothesized that the relationship between men's baseline loneliness and depression six months later would be mediated by their sense of feeling understood at three months.</div></div><div><h3>Materials and methods</h3><div>An international community sample of men (<em>n</em> = 300) were recruited from the men's mental health website <em>HeadsUpGuys</em> and completed anonymous online surveys at three time points, including baseline, three months, and six months. The longitudinal design involved self-reported assessment of participants' loneliness, sense of feeling deeply understood, and depressive symptoms at all timepoints.</div></div><div><h3>Results</h3><div>The mediation model revealed men's perception of feeling deeply understood by others to be a significant temporal mediator of the association between loneliness and depression.</div></div><div><h3>Conclusions</h3><div>Interventions that reduce or prevent men's loneliness and existential isolation may significantly reduce men's depression risk.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 47-51"},"PeriodicalIF":3.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinguished multimodal imaging features affected by COVID-19 in major depressive disorder patients

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-01-30 DOI: 10.1016/j.jpsychires.2025.01.053

Taipeng Sun , Chenguang Jiang , Yubo Zhang , Yueying Li , Gang Chen , Yue Zhou , Wei Xu , Linlin You , Youyong Kong , Wenhao Jiang , Yonggui Yuan

Objectives

Growing attention has been directed toward the structural and functional alterations among individuals infected with COVID-19. However, data on its impact on patients with Major Depressive Disorder (MDD) remain limited.

Methods

This study investigates the effects of COVID-19 on patients with MDD and healthy controls (HCs) using MRI scans. Participants were categorized into four groups: MDD patients before (n = 165) and after COVID-19 infection (n = 70), HCs before (n = 108) and after COVID-19 infection (n = 57). All participants underwent T1-weighted imaging, diffusion tensor imaging (DTI), and resting-state functional MRI from January 2022 to August 2023.

Results

Structural alterations associated with COVID-19 were predominantly observed in the white matter (WM) rather than the gray matter (GM), with specific involvement noted in the superior longitudinal fasciculus tract, Forceps minor tract, and cingulum-cingulate gyrus tract among patients with MDD. Functional changes were spread from GM to WM. The bilateral supplementary motor area, the left angular gyrus, the left subcortical regions (amygdala and parahippocampal gyrus), and various WM tracts showed significant infection-related changes across groups.

Conclusion

COVID-19 infection induces significant microstructural damage of WM in healthy individuals and exacerbates white matter microstructural injury of MDD. These findings suggest that WM might be more susceptible to COVID-19 effects than GM in both MDD patients and HCs.

{"title":"Distinguished multimodal imaging features affected by COVID-19 in major depressive disorder patients","authors":"Taipeng Sun , Chenguang Jiang , Yubo Zhang , Yueying Li , Gang Chen , Yue Zhou , Wei Xu , Linlin You , Youyong Kong , Wenhao Jiang , Yonggui Yuan","doi":"10.1016/j.jpsychires.2025.01.053","DOIUrl":"10.1016/j.jpsychires.2025.01.053","url":null,"abstract":"<div><h3>Objectives</h3><div>Growing attention has been directed toward the structural and functional alterations among individuals infected with COVID-19. However, data on its impact on patients with Major Depressive Disorder (MDD) remain limited.</div></div><div><h3>Methods</h3><div>This study investigates the effects of COVID-19 on patients with MDD and healthy controls (HCs) using MRI scans. Participants were categorized into four groups: MDD patients before (n = 165) and after COVID-19 infection (n = 70), HCs before (n = 108) and after COVID-19 infection (n = 57). All participants underwent T1-weighted imaging, diffusion tensor imaging (DTI), and resting-state functional MRI from January 2022 to August 2023.</div></div><div><h3>Results</h3><div>Structural alterations associated with COVID-19 were predominantly observed in the white matter (WM) rather than the gray matter (GM), with specific involvement noted in the superior longitudinal fasciculus tract, Forceps minor tract, and cingulum-cingulate gyrus tract among patients with MDD. Functional changes were spread from GM to WM. The bilateral supplementary motor area, the left angular gyrus, the left subcortical regions (amygdala and parahippocampal gyrus), and various WM tracts showed significant infection-related changes across groups.</div></div><div><h3>Conclusion</h3><div>COVID-19 infection induces significant microstructural damage of WM in healthy individuals and exacerbates white matter microstructural injury of MDD. These findings suggest that WM might be more susceptible to COVID-19 effects than GM in both MDD patients and HCs.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 1-9"},"PeriodicalIF":3.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143134481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibromyalgia and the painful self: A meta-analysis of resting-state fMRI data

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-01-30 DOI: 10.1016/j.jpsychires.2025.01.048

Marco Cavicchioli , Andrea Scalabrini , Filippo Nimbi , Alessandro Torelli , Sara Bottiroli , Anna Pichiecchio , Elena Prodi , Cristina Trentini , Piercarlo Sarzi-Puttini , Federica Galli

Fibromyalgia (FM) is a complex medical condition. The nested hierarchical model of self and its extension to the pain matrix could represent an integrated theoretical framework that might comprehensively captures FM clinical feautres. A multi-level meta-analysis was conducted. Resting-state functional connectivity (RS-FC) studies that compared patients with FM and healthy controls (HCs) were included. The association between RS-FC among self-related brain regions and pain intensity was also explored in the FM group. Eleven studies were eligible for meta-analytic procedures. Patients with FM, compared to HCs, were characterized by an increased RS-FC between the default mode network (DMN) and areas ascribed to interoceptive (e.g., insula) and exteroceptive (e.g., premotor, visual/auditory cortices) self layers. The clinical group also showed a reduced RS-FC among regions of the pain matrix (i.e., periaqueductal gray matter, somatosensory areas) involved in pain modulation. An increased RS-FC within DMN together with a heightened RS-FC between DMN and interoceptive self areas were positively associated to pain intensity reported by patients with FM. The nested hierarchical model of self and its extension to the pain matrix might represent comprehensive neurobiological backgrounds for clarifying core mind-body clinical features of FM.

{"title":"Fibromyalgia and the painful self: A meta-analysis of resting-state fMRI data","authors":"Marco Cavicchioli , Andrea Scalabrini , Filippo Nimbi , Alessandro Torelli , Sara Bottiroli , Anna Pichiecchio , Elena Prodi , Cristina Trentini , Piercarlo Sarzi-Puttini , Federica Galli","doi":"10.1016/j.jpsychires.2025.01.048","DOIUrl":"10.1016/j.jpsychires.2025.01.048","url":null,"abstract":"<div><div>Fibromyalgia (FM) is a complex medical condition. The nested hierarchical model of self and its extension to the pain matrix could represent an integrated theoretical framework that might comprehensively captures FM clinical feautres. A multi-level meta-analysis was conducted. Resting-state functional connectivity (RS-FC) studies that compared patients with FM and healthy controls (HCs) were included. The association between RS-FC among self-related brain regions and pain intensity was also explored in the FM group. Eleven studies were eligible for meta-analytic procedures. Patients with FM, compared to HCs, were characterized by an increased RS-FC between the default mode network (DMN) and areas ascribed to interoceptive (e.g., insula) and exteroceptive (e.g., premotor, visual/auditory cortices) self layers. The clinical group also showed a reduced RS-FC among regions of the pain matrix (i.e., periaqueductal gray matter, somatosensory areas) involved in pain modulation. An increased RS-FC within DMN together with a heightened RS-FC between DMN and interoceptive self areas were positively associated to pain intensity reported by patients with FM. The nested hierarchical model of self and its extension to the pain matrix might represent comprehensive neurobiological backgrounds for clarifying core mind-body clinical features of FM.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 61-71"},"PeriodicalIF":3.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of transcranial alternating current stimulation on measures of cognition and symptom scores in Chinese patients with schizophrenia

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-01-30 DOI: 10.1016/j.jpsychires.2025.01.055

Xinyi Cao , Yong Liu , Yuanyu Lu , Hua Jin , Henry Sershen , John M. Davis , Chunbo Li , Robert C. Smith

Transcranial alternating current stimulation (tACS) may have effects on cognition and symptoms in psychiatric illness but there have been few randomized controlled studies in people with schizophrenia. We conducted a randomized sham-controlled double-blind study of 40 Hz tACS on measures of cognition and symptoms scores in 50 patients diagnosed with DSM-5 schizophrenia. tACS was delivered in 10 sessions (20 min each) over a 2-week period. Evaluations were conducted with multiple cognitive and symptom batteries after 10 sessions and at 2 weeks and 4 weeks post-treatment, and also on-line during the tACS stimulation session 1. The primary outcome measured changes in the MATRICS overall composite score. The results showed no statistically significant (P < 0.05) effects of active vs. sham on improvement in any of the cognitive measures or PANSS rated positive or negative symptoms. There was a trend (P < 0.06) for the MATRICS Domain score of verbal learning to show greater improvement of active tACS compared to sham within 1–2 days after the 10 tACS sessions. Additional trials are needed to determine the effective tACS parameters targeting cognition and symptoms of schizophrenia.

{"title":"Effects of transcranial alternating current stimulation on measures of cognition and symptom scores in Chinese patients with schizophrenia","authors":"Xinyi Cao , Yong Liu , Yuanyu Lu , Hua Jin , Henry Sershen , John M. Davis , Chunbo Li , Robert C. Smith","doi":"10.1016/j.jpsychires.2025.01.055","DOIUrl":"10.1016/j.jpsychires.2025.01.055","url":null,"abstract":"<div><div>Transcranial alternating current stimulation (tACS) may have effects on cognition and symptoms in psychiatric illness but there have been few randomized controlled studies in people with schizophrenia. We conducted a randomized sham-controlled double-blind study of 40 Hz tACS on measures of cognition and symptoms scores in 50 patients diagnosed with DSM-5 schizophrenia. tACS was delivered in 10 sessions (20 min each) over a 2-week period. Evaluations were conducted with multiple cognitive and symptom batteries after 10 sessions and at 2 weeks and 4 weeks post-treatment, and also on-line during the tACS stimulation session 1. The primary outcome measured changes in the MATRICS overall composite score. The results showed no statistically significant (<em>P</em> < 0.05) effects of active vs. sham on improvement in any of the cognitive measures or PANSS rated positive or negative symptoms. There was a trend (<em>P</em> < 0.06) for the MATRICS Domain score of verbal learning to show greater improvement of active tACS compared to sham within 1–2 days after the 10 tACS sessions. Additional trials are needed to determine the effective tACS parameters targeting cognition and symptoms of schizophrenia.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 10-15"},"PeriodicalIF":3.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143356214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PTSS, perceived stress, and social media use affecting somatic symptoms in healthcare workers recovering from COVID after ending China's dynamic zero-COVID policy: A moderated mediation model

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-01-28 DOI: 10.1016/j.jpsychires.2025.01.031

Yafei Chen , Zhiruo Zhou , Wenwen Ou , Mohan Ma , Fanyu Meng , Chunxi Ke , Mi Wang , Yumeng Ju , Yan Zhang

Background

Persistent somatic symptoms brought by COVID are a matter of concern. Post-traumatic stress symptoms (PTSS) and perceived stress have been recognized as risk factors for somatic symptoms. Recently, the associations between social media use and COVID-related PTSS have also been noticed. However, the pathways these factors contribute to persistent somatic symptoms after COVID remain unclear. This study aims to investigate the role of perceived stress as a mediator in COVID-related PTSS and somatic symptoms, and whether social media use moderated the mediation in a sample of healthcare workers (HCWs) during the subacute phase of COVID in the context of the end of China's dynamic zero-COVID policy.

Methods

Questionnaire data from 2281 Chinese HCWs were included in the study. COVID-related PTSS, perceived stress, and somatic symptoms were measured, and a moderated mediator model was developed.

Results

The effect of COVID-related PTSS on somatic symptoms was partially mediated by perceived stress. Moreover, social media use positively moderated the relationship between COVID-related PTSS and perceived stress. That is, at higher frequencies of social media use, COVID-related PTSS played a stronger role in perceived stress.

Conclusion

Our findings suggest that perceived stress and frequency of social media use play a facilitating role in the impact of COVID-related PTSS on somatic symptoms. From a psychosocial perspective, this study identifies psychological interventions targeting stress and benign media communication as potential interventions for persistent somatic symptoms after COVID infection and prevention of long-term COVID.

{"title":"PTSS, perceived stress, and social media use affecting somatic symptoms in healthcare workers recovering from COVID after ending China's dynamic zero-COVID policy: A moderated mediation model","authors":"Yafei Chen , Zhiruo Zhou , Wenwen Ou , Mohan Ma , Fanyu Meng , Chunxi Ke , Mi Wang , Yumeng Ju , Yan Zhang","doi":"10.1016/j.jpsychires.2025.01.031","DOIUrl":"10.1016/j.jpsychires.2025.01.031","url":null,"abstract":"<div><h3>Background</h3><div>Persistent somatic symptoms brought by COVID are a matter of concern. Post-traumatic stress symptoms (PTSS) and perceived stress have been recognized as risk factors for somatic symptoms. Recently, the associations between social media use and COVID-related PTSS have also been noticed. However, the pathways these factors contribute to persistent somatic symptoms after COVID remain unclear. This study aims to investigate the role of perceived stress as a mediator in COVID-related PTSS and somatic symptoms, and whether social media use moderated the mediation in a sample of healthcare workers (HCWs) during the subacute phase of COVID in the context of the end of China's dynamic zero-COVID policy.</div></div><div><h3>Methods</h3><div>Questionnaire data from 2281 Chinese HCWs were included in the study. COVID-related PTSS, perceived stress, and somatic symptoms were measured, and a moderated mediator model was developed.</div></div><div><h3>Results</h3><div>The effect of COVID-related PTSS on somatic symptoms was partially mediated by perceived stress. Moreover, social media use positively moderated the relationship between COVID-related PTSS and perceived stress. That is, at higher frequencies of social media use, COVID-related PTSS played a stronger role in perceived stress.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that perceived stress and frequency of social media use play a facilitating role in the impact of COVID-related PTSS on somatic symptoms. From a psychosocial perspective, this study identifies psychological interventions targeting stress and benign media communication as potential interventions for persistent somatic symptoms after COVID infection and prevention of long-term COVID.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"183 ","pages":"Pages 86-92"},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global prevalence of depression, anxiety, and stress symptoms in different trimesters of pregnancy: A meta-analysis and meta-regression 不同孕期抑郁、焦虑和压力症状的全球流行率：荟萃分析和荟萃回归。

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-01-01 DOI: 10.1016/j.jpsychires.2024.11.070

Halimatusaadiyah Abdul Aziz , Huda Dianah Binte Yahya , Wen Wei Ang , Ying Lau

The global prevalence of psychological problems in different trimesters is unclear due to methodological constraints in previous reviews. A precise estimate would be a key first step in raising awareness and allocating resources. This review aims to (1) calculate the global prevalence of depression, anxiety, and stress symptoms during different trimesters and (2) determine the factors influencing their prevalence estimates. A comprehensive search across eight databases was conducted. The meta packages in R software were used to perform meta-analysis, subgroup analysis, and meta-regression analysis. The Newcastle Ottawa Scale was used to assess the study quality, while the Grading of Recommendations, Assessment, Development, and Evaluation method was utilized to assess the certainty of the evidence. A total of 88 studies with 61,719 participants across 48 countries were included. The prevalences of depression, anxiety, and stress symptoms during all trimesters were 27% (95% CI: 23–31), 37% (95% CI: 31–42), and 26% (95% CI: 9–49), respectively. The second trimester had the highest prevalence of depression (30%) and anxiety (28%) symptoms, whereas the third trimester had the highest prevalence of stress symptoms (52%). A series of subgroup and meta-regression analyses revealed that regions, economic levels of the country, setting, the COVID-19 pandemic, and quality of study were significant factors. Most studies were high quality, but the certainty of the evidence was very low. Findings can contribute as evidence to raising awareness about specific psychological problems during different trimesters. Implementing effective policies and launching targeted interventions can help minimize the prevalence.

由于之前的审查在方法上的限制，不同孕期心理问题的全球流行率还不清楚。精确的估计将是提高认识和分配资源的关键第一步。本综述旨在：（1）计算抑郁、焦虑和压力症状在不同孕期的全球流行率；（2）确定影响其流行率估计的因素。我们对八个数据库进行了全面检索。使用 R 软件中的元软件包进行了元分析、亚组分析和元回归分析。采用纽卡斯尔-渥太华量表评估研究质量，并采用建议、评估、发展和评价分级法评估证据的确定性。研究共纳入了 88 项研究，涉及 48 个国家的 61,719 名参与者。各孕期抑郁、焦虑和压力症状的患病率分别为 27% (95% CI: 23-31)、37% (95% CI: 31-42) 和 26% (95% CI: 9-49)。第二个孕期抑郁（30%）和焦虑（28%）症状的发生率最高，而第三个孕期压力症状的发生率最高（52%）。一系列分组和元回归分析表明，地区、国家经济水平、环境、COVID-19 大流行和研究质量是重要因素。大多数研究的质量较高，但证据的确定性很低。研究结果有助于提高人们对不同孕期特定心理问题的认识。实施有效的政策和启动有针对性的干预措施有助于最大限度地降低患病率。

{"title":"Global prevalence of depression, anxiety, and stress symptoms in different trimesters of pregnancy: A meta-analysis and meta-regression","authors":"Halimatusaadiyah Abdul Aziz , Huda Dianah Binte Yahya , Wen Wei Ang , Ying Lau","doi":"10.1016/j.jpsychires.2024.11.070","DOIUrl":"10.1016/j.jpsychires.2024.11.070","url":null,"abstract":"<div><div>The global prevalence of psychological problems in different trimesters is unclear due to methodological constraints in previous reviews. A precise estimate would be a key first step in raising awareness and allocating resources. This review aims to (1) calculate the global prevalence of depression, anxiety, and stress symptoms during different trimesters and (2) determine the factors influencing their prevalence estimates. A comprehensive search across eight databases was conducted. The <em>meta</em> packages in R software were used to perform meta-analysis, subgroup analysis, and meta-regression analysis. The Newcastle Ottawa Scale was used to assess the study quality, while the Grading of Recommendations, Assessment, Development, and Evaluation method was utilized to assess the certainty of the evidence. A total of 88 studies with 61,719 participants across 48 countries were included. The prevalences of depression, anxiety, and stress symptoms during all trimesters were 27% (95% CI: 23–31), 37% (95% CI: 31–42), and 26% (95% CI: 9–49), respectively. The second trimester had the highest prevalence of depression (30%) and anxiety (28%) symptoms, whereas the third trimester had the highest prevalence of stress symptoms (52%). A series of subgroup and meta-regression analyses revealed that regions, economic levels of the country, setting, the COVID-19 pandemic, and quality of study were significant factors. Most studies were high quality, but the certainty of the evidence was very low. Findings can contribute as evidence to raising awareness about specific psychological problems during different trimesters. Implementing effective policies and launching targeted interventions can help minimize the prevalence.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 528-546"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factor structure, reliability and validity of an Indian Scale for Assessment of Nomophobia (ISAN) among college students: A multicentre Indian study 印度大学生无恐惧症量表（ISAN）的因素结构、信度和效度：一项多中心印度研究

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research

Pub Date : 2025-01-01 DOI: 10.1016/j.jpsychires.2024.12.036

Rajeev Ranjan , Yatan Pal Singh Balhara , Biswa Ranjan Mishra , Shamshad Ahmad , Siddharth Sarkar , Ayushi Bharti , Sahadeb Panigrahi , Muskan Sinha , Akanksha Jayant Rajguru , Pankaj Kumar , Debadatta Mohapatra , Arpit Parmar , Meha Jain

Background

The current severity assessment measures for nomophobia have issues related to clinical applicability, which makes them difficult to be consistently applied in the Indian context. We aimed to develop a valid and reliable instrument for the assessment of severity of Nomophobia.

Methods

This study was a two-phase, exploratory sequential mixed method design conducted across three centres in India. The development of the questionnaire included identification of the domains and items, inputs from experts and refining the questionnaire. EFA was carried out to check the internal consistency among items. CFA was carried out to test the factor structure of ISAN. Concurrent validity with NMP-Q was ascertained. Convergent and discriminant validity were tested using bivariate correlation analysis.

Results

The qualitative findings from the initial exploration were developed into 27-item ISAN reviewed by experts for content validity. EFA showed that the questionnaire has good internal consistency (Cronbach's alpha reliability coefficient = 0.934) with a five-factor pattern matrix. CFA explained five-factor structure (Digital compulsion, Digital Intensement, Digital Obsession, Digital Detachment Distress and Digital Engagement) was deemed to be the most tenable comprising of 21 items. ISAN fits good on all indices (CMIN/df = 2.44, CFI = 0.93, RMSEA = 0.05, TLI = 0.92, IFI = 0.93) for the five-factor structure. Concurrent validity with NMP-Q was good (r = 0.695). Good to moderate associations were noted for the convergent (r = 0.985) and discriminant validity (r = −0.560) respectively.

Conclusion

ISAN (Indian Scale for Assessment of Nomophobia) is an accurate and reliable instrument that can measure nomophobia in the Indian youth population.

背景：目前的无恐惧症严重程度评估措施存在与临床适用性相关的问题，这使得它们难以在印度的情况下一致应用。我们的目的是开发一种有效和可靠的工具来评估Nomophobia的严重程度。方法：本研究是在印度的三个中心进行的两阶段探索性顺序混合方法设计。问卷的开发包括领域和项目的识别、专家的输入和问卷的完善。进行EFA检查项目之间的内部一致性。采用CFA对ISAN的因子结构进行检验。确定了NMP-Q的并发效度。采用双变量相关分析检验收敛效度和判别效度。结果：初步探索的定性发现被发展成27个项目的ISAN，由专家对内容效度进行审查。EFA结果表明，问卷具有良好的内部一致性（Cronbach's α信度系数= 0.934），具有五因子模式矩阵。CFA解释说，五因素结构（数字强迫、数字强化、数字痴迷、数字脱离困扰和数字参与）被认为是最站得住的，包括21个项目。ISAN对五因素结构的所有指标（CMIN/df = 2.44, CFI = 0.93, RMSEA = 0.05, TLI = 0.92, IFI = 0.93）都很适合。NMP-Q的并发效度较好（r = 0.695）。收敛效度（r = 0.985）和判别效度（r = -0.560）分别为良好至中度关联。结论：ISAN （Indian Scale for Assessment of Nomophobia）是一种准确、可靠的工具，可以测量印度青年人群的Nomophobia。

{"title":"Factor structure, reliability and validity of an Indian Scale for Assessment of Nomophobia (ISAN) among college students: A multicentre Indian study","authors":"Rajeev Ranjan , Yatan Pal Singh Balhara , Biswa Ranjan Mishra , Shamshad Ahmad , Siddharth Sarkar , Ayushi Bharti , Sahadeb Panigrahi , Muskan Sinha , Akanksha Jayant Rajguru , Pankaj Kumar , Debadatta Mohapatra , Arpit Parmar , Meha Jain","doi":"10.1016/j.jpsychires.2024.12.036","DOIUrl":"10.1016/j.jpsychires.2024.12.036","url":null,"abstract":"<div><h3>Background</h3><div>The current severity assessment measures for nomophobia have issues related to clinical applicability, which makes them difficult to be consistently applied in the Indian context. We aimed to develop a valid and reliable instrument for the assessment of severity of Nomophobia.</div></div><div><h3>Methods</h3><div>This study was a two-phase, exploratory sequential mixed method design conducted across three centres in India. The development of the questionnaire included identification of the domains and items, inputs from experts and refining the questionnaire. EFA was carried out to check the internal consistency among items. CFA was carried out to test the factor structure of ISAN. Concurrent validity with NMP-Q was ascertained. Convergent and discriminant validity were tested using bivariate correlation analysis.</div></div><div><h3>Results</h3><div>The qualitative findings from the initial exploration were developed into 27-item ISAN reviewed by experts for content validity. EFA showed that the questionnaire has good internal consistency (Cronbach's alpha reliability coefficient = 0.934) with a five-factor pattern matrix. CFA explained five-factor structure (Digital compulsion, Digital Intensement, Digital Obsession, Digital Detachment Distress and Digital Engagement) was deemed to be the most tenable comprising of 21 items. ISAN fits good on all indices (CMIN/df = 2.44, CFI = 0.93, RMSEA = 0.05, TLI = 0.92, IFI = 0.93) for the five-factor structure. Concurrent validity with NMP-Q was good (r = 0.695). Good to moderate associations were noted for the convergent (r = 0.985) and discriminant validity (r = −0.560) respectively.</div></div><div><h3>Conclusion</h3><div>ISAN (<strong>I</strong>ndian <strong>S</strong>cale for <strong>A</strong>ssessment of <strong>N</strong>omophobia) is an accurate and reliable instrument that can measure nomophobia in the Indian youth population.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"181 ","pages":"Pages 599-606"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0