Journal of Supercritical Fluids最新文献

英文中文

A supercritical carbon dioxide pre-isothermal crystallization foaming strategy for lightweight TPU/PLA composite foam with enhanced compressive strength and elasticity 提高抗压强度和弹性的轻质TPU/PLA复合泡沫的超临界二氧化碳预等温结晶发泡策略

IF 3.9 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-02-03 DOI: 10.1016/j.supflu.2026.106921

Huazhen Jiang, Panfeng Shao, Guangxian Li, Xia Liao

引用次数: 0

Synergistic Extraction Technologies: A Comprehensive Review of EASCFE and Its Applications 协同萃取技术：EASCFE及其应用综述

IF 3.9 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-02-02 DOI: 10.1016/j.supflu.2026.106885

Rajanikanta Acharya, Mydavolu Sai Niharika, Divina Christopher, Anitha Anbalagan, Meenakshi Sundaram Muthuraman

引用次数: 0

Numerical assessment of scale-up criteria in a wall-cooled reactor for hydrogen combustion in supercritical water 超临界水中氢燃烧壁冷堆放大准则的数值评定

IF 3.9 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-02-02 DOI: 10.1016/j.supflu.2026.106919

Mingjing Fan, Xiaoge Zhang, Yu Zhang, Haoze Wang, Hao Wang, Youjun Lu

引用次数: 0

Material selection strategy against high-temperature high-pressure Cl/CO2-containing corrosive environment 高温高压含Cl/ co2腐蚀环境下的材料选择策略

IF 3.9 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-01-31 DOI: 10.1016/j.supflu.2026.106918

Bihui Wang, Weikai Yi, Xuefei Gao, Xinyu Hu, Kaiyang Li

引用次数: 0

Green preparation of polyvinyl chloride/epoxy resin blend foams using supercritical CO2 超临界CO2绿色制备聚氯乙烯/环氧树脂共混泡沫

IF 3.9 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-01-29 DOI: 10.1016/j.supflu.2026.106916

Xuelin Zhang, Xiulu Gao, Qiyuan He, Haonan Chen, Yichong Chen, Ling Zhao, Dongdong Hu

引用次数: 0

Sequential supercritical and pressurized liquid extraction of flavonoids from Astragalus membranaceus: Optimizing yield and preserving glycoside integrity 连续超临界和加压液体提取黄芪黄酮：优化得率和保持糖苷完整性

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-01-23 DOI: 10.1016/j.supflu.2026.106917

Marie Sajfrtová , Helena Sovová , Naděžda Vrchotová , Jan Tříska , Roman Pavela

The root of Astragalus membranaceus (AR), one of the most popular Chinese herbal medicines, is used to treat various diseases. Flavonoids (FL), both glycosides and aglycons, belong to its biologically active components. The purpose of the research was to examine the effect of AR sequential extraction on the yield of flavonoids and their composition in extracts. Two high-pressure extraction methods were applied, supercritical fluid extraction (SFE) and pressurized liquid extraction (PLE). Ethanol, methanol, ethyl acetate and water were used as CO₂ modifiers and solvents. The complete succession of applied extraction solvents was neat supercritical CO₂, modified CO₂, pressurized organic solvent and overheated water. The PLE results show an increasing yield of FL with increasing modifier polarity from ethyl acetate to ethanol and methanol, and then a decrease for water. The maximum yield of FL, 9.1 mg/100 g AR, was provided by PLE with ethanol at 120 °C and 10 MPa. Similar was the relationship between solvent power of CO₂ modifiers and their polarity in SFE, but the yield of FL was an order of magnitude lower. Thus, according to the FL yield, there was practically no difference between a simple PLE and more complicated sequential extraction SFE, PLE. A marked difference was however in the glycosides-to-aglycons ratio, which was higher in sequential extraction. It is hypothesized that water residue in AR is removed by SFE, preventing thus hydrolysis of glycosides during the following PLE.

黄芪（Astragalus aceus， AR）的根是最受欢迎的中草药之一，用于治疗各种疾病。黄酮类化合物（Flavonoids， FL）是一种具有生物活性的成分，可分为糖苷类和糖苷类。本研究的目的是考察AR序贯提取对黄酮类化合物得率及其组成的影响。采用了超临界流体萃取（SFE）和加压液体萃取（PLE）两种高压萃取方法。采用乙醇、甲醇、乙酸乙酯和水作为CO2的改性剂和溶剂。萃取溶剂依次为纯超临界CO2、改性CO2、加压有机溶剂和过热水。PLE结果表明，随着改性剂极性的增加，从乙酸乙酯到乙醇和甲醇的收率增加，然后对水的收率降低。在120°C、10 MPa条件下，乙醇萃取的最大得率为9.1 mg/100 g AR。在SFE中，CO2改性剂的溶剂功率与其极性之间的关系类似，但FL的产率要低一个数量级。因此，从FL得率来看，简单的PLE和更复杂的顺序提取SFE， PLE几乎没有区别。然而，在糖苷与糖苷的比例上存在显著差异，顺序提取的糖苷与糖苷的比例更高。假设AR中的水残渣被SFE除去，从而在接下来的PLE中防止糖苷水解。

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引用次数: 0

Measurement and prediction of levofloxacin and metacetamol solubility in supercritical carbon dioxide 左氧氟沙星、甲醋氨醇在超临界二氧化碳中的溶解度测定与预测

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-01-23 DOI: 10.1016/j.supflu.2026.106915

Yung-Chun Yang , Hsu-Chen Wang , Chie-Shaan Su , Chieh-Ming Hsieh

The solubility of pharmaceutical compounds in supercritical carbon dioxide (scCO₂) is crucial for process development. In this study, the solubility of levofloxacin and metacetamol was measured using a high-pressure semi-flow apparatus at 313.2 K, 323.2 K, and 333.2 K, over a pressure range of 12 MPa to 24 MPa for levofloxacin and 12 MPa to 22 MPa for metacetamol. Solubilities (in mole fraction) ranged from 1.51 × 10⁻⁷ to 2.71 × 10⁻⁶ for levofloxacin and from 8.00 × 10⁻⁷ to 7.32 × 10⁻⁶ for metacetamol. Semi-empirical correlations proposed by Chrastil, Mendez-Santiago & Teja, Kumar & Johnston, and Bartle reproduced the data with average absolute relative deviations (AARD-y) of 2.89–3.90 % for levofloxacin and 2.64–6.73 % for metacetamol. Two thermodynamic models based on the Peng-Robinson equation of state (PR EOS), PR+VDW and PR+MHV1 +Wilson, were also used to correlate the data, giving AARD values of 8.53 % and 23.6 % for levofloxacin, and 4.53 % and 8.21 % for metacetamol, respectively. In addition, the PR EOS was combined with COSMO-SAC through the MHV1 mixing rule to enable solubility prediction without adjusting system-specific parameters. This predictive framework yielded average logarithmic deviation (ALD-y) values of 0.229 for levofloxacin and 0.169 for metacetamol, corresponding to AARDs of 39.5 % and 48.7 %.

药物化合物在超临界二氧化碳（scCO2）中的溶解度对工艺开发至关重要。在本研究中，左氧氟沙星和metacetamol在313.2 K， 323.2 K和333.2 K下的高压半流动装置测量了溶解度，左氧氟沙星的压力范围为12 MPa至24 MPa， metacetamol的压力范围为12 MPa至22 MPa。左氧氟沙星的溶解度（以摩尔分数计）为1.51 × 10−7 ~ 2.71 × 10−6，氨对乙酰氨基酚的溶解度为8.00 × 10−7 ~ 7.32 × 10−6。由Chrastil， Mendez-Santiago & Teja， Kumar & Johnston和Bartle提出的半经验相关性再现了数据，左氧氟沙星的平均绝对相对偏差（AARD-y）为2.89-3.90 %，metacetamol的平均绝对相对偏差为2.64-6.73 %。基于彭氏状态方程（PR - EOS）的两个热力学模型PR+VDW和PR+MHV1 +Wilson也被用于关联数据，左氧氟沙星的AARD值分别为8.53 %和23.6 %，梅对乙酰氨基酚的AARD值分别为4.53 %和8.21 %。此外，通过MHV1混合规则将PR EOS与cosmos - sac结合，无需调整系统特定参数即可实现溶解度预测。该预测框架对左氧氟沙星和对乙酰氨基酚的平均对数偏差（ALD-y）值分别为0.229和0.169，对应的ards分别为39.5 %和48.7 %。

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引用次数: 0

Multi-objective optimization of a novel non-uniform variable cross-section zigzag printed circuit heat exchanger for supercritical CO2 Brayton Cycle 超临界CO2布雷顿循环非均匀变截面之字形印刷电路换热器多目标优化

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-01-21 DOI: 10.1016/j.supflu.2026.106904

Houdong Shi , Bingguo Zhu , Qing Zhang

This study proposes a novel non-uniform variable cross-section zigzag printed circuit heat exchanger (UZPCHE) to address the demand for high-performance and compact heat exchangers in the precooler of the supercritical CO₂ Brayton cycle (SCO₂-BC). Three geometric parameters including the variable diameter (d1) and the inner and outer chord lengths (L1 and L2) of the turning region are selected as design variables, with the Nusselt number (Nu), friction factor (f), and compactness performance (Q/V) as optimization objectives. A quadratic response surface model (RSM) is established using the Box–Behnken design, and grey relational analysis (GRA) is employed to elucidate the influence degree of geometric parameters on thermal–hydraulic performance. Subsequently, a multi-objective optimization framework integrating the non-dominated sorting genetic algorithm II (NSGA-II) and the technique for order preference by similarity to ideal solution (TOPSIS) is applied to derive the optimal compromise design. The results indicate that the developed RSM exhibits high predictive accuracy. The d1 is identified as the dominant parameter, contributing approximately 38 % to the objective functions. The optimized non-uniform variable-cross-section printed circuit heat exchanger (UZPCHE, d1 = 1.2 mm, L1 = 2.5 mm, L2 = 2.7 mm) exhibits superior thermohydraulic performance (PEC=1.173) compared to the traditional zigzag printed circuit heat exchanger (TZPCHE), wavy channel printed circuit heat exchanger (WAPCHE), and straight channel printed circuit heat exchanger (STPCHE). Furthermore, the optimized UZPCHE reduces the maximum equivalent stress in the solid region compared to the TZPCHE. These findings provide valuable insights for the structural optimization of printed circuit heat exchangers in supercritical CO₂ power systems.

针对超临界CO2布雷顿循环（SCO2-BC）预冷器对高性能紧凑型换热器的需求，提出了一种新型非均匀可变截面之字印刷电路换热器（UZPCHE）。选取车体变径（d1）和内外弦长（L1和L2） 3个几何参数作为设计变量，以努塞尔数（Nu）、摩擦系数(f)和紧致性能（Q/V）为优化目标。采用Box-Behnken设计方法建立了二次响应面模型（RSM），并采用灰色关联分析（GRA）分析几何参数对热工性能的影响程度。随后，将非支配排序遗传算法II （NSGA-II）与理想解相似性排序偏好技术（TOPSIS）相结合，建立了多目标优化框架，推导出最优妥协设计。结果表明，该方法具有较高的预测精度。d1被确定为主导参数，对目标函数的贡献约为38% %。优化后的非均匀变截面印刷电路换热器（UZPCHE, d1 = 1.2 mm, L1 = 2.5 mm, L2 = 2.7 mm）与传统的之字形印刷电路换热器（TZPCHE）、波浪形印刷电路换热器（WAPCHE）和直线型印刷电路换热器（STPCHE）相比，具有更好的热液性能（PEC=1.173）。此外，与TZPCHE相比，优化后的UZPCHE降低了固体区的最大等效应力。这些发现为超临界CO2电力系统中印刷电路热交换器的结构优化提供了有价值的见解。

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引用次数: 0

Study on the dynamic response mechanisms of a lead-bismuth fast reactor coupled with a transcritical CO2 power cycle 跨临界CO2动力循环耦合的铅铋快堆动态响应机制研究

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-01-21 DOI: 10.1016/j.supflu.2026.106903

Zhaoyang Yuan , Xuanang Zhang , Jintao He , Yonghao Zhang , Jie Yu , Zhen Wang , Lingfeng Shi , Hua Tian , Gequn Shu

The integration of a lead-bismuth fast reactor (LFR) with a transcritical CO₂ (T-CO₂) power cycle represents a promising offshore nuclear energy solution. Although prior research has advanced the primary and secondary circuits separately, their dynamic interactions under tightly coupled conditions remain insufficiently explored. This work establishes a dynamic system model to investigate bidirectional disturbance propagation and load-following coordination between the two circuits. Results indicate that reducing reactor power by 5 % and 10 % decreases secondary circuit output by 13.8 % and 28.4 %, respectively. Variations in secondary circuit parameters, such as pump speed and cold source temperature, alter the CO₂ mass flow rate and evaporator heat transfer, leading to temperature changes in the primary coolant. Through inherent temperature feedback, the reactor autonomously adjusts its power, demonstrating strong closed-loop coupling. Notably, pump speed has a greater influence on secondary circuit output than cold source temperature, contributing approximately 5.6 % more to the output work variation. During load following, adjusting only reactor power lowers both turbine inlet temperature and system efficiency. In contrast, coordinated adjustment of reactor power and secondary circuit flow maintains a more stable thermal state while adapting to load changes, improving average thermal efficiency by 2.1 % compared to the reactor-only strategy. This study clarifies key thermophysical coupling mechanisms in the LFR–T-CO₂ system and provides a valuable reference for the coordinated control of marine nuclear power systems under dynamic operating conditions.

铅铋快堆（LFR）与跨临界CO2 （T-CO2）动力循环的集成代表了一种有前途的海上核能解决方案。虽然先前的研究已经分别提出了主回路和次回路，但它们在紧密耦合条件下的动态相互作用仍然没有得到充分的探讨。本文建立了一个动态系统模型来研究两个电路之间的双向扰动传播和负载跟随协调。结果表明，电抗器功率每降低5 %和10 %，二次回路输出分别降低13.8 %和28.4 %。二次回路参数的变化，如泵转速和冷源温度，会改变CO2质量流量和蒸发器传热，从而导致一次冷却剂的温度变化。电抗器通过固有的温度反馈，自主调节功率，表现出强闭环耦合。值得注意的是，泵转速比冷源温度对二次回路输出的影响更大，对输出功变化的贡献约为5.6% %。在负荷跟踪期间，仅调整反应堆功率会降低涡轮入口温度和系统效率。相比之下，电抗器功率和二次回路流量的协调调整在适应负荷变化的同时保持了更稳定的热状态，与仅电抗器策略相比，平均热效率提高了2.1 %。本研究阐明了LFR-T-CO2系统中关键的热物理耦合机理，为船舶核电系统在动态运行条件下的协调控制提供了有价值的参考。

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Solid solubility measurement and microparticle production by supercritical process: A case study of pirfenidone 超临界工艺固溶度测定及微粒生产：以吡非尼酮为例

IF 4.4 3区工程技术 Q2 CHEMISTRY, PHYSICAL

Journal of Supercritical Fluids

Pub Date : 2026-01-20 DOI: 10.1016/j.supflu.2026.106899

Yun Chang , Yung-Chun Yang , Chieh-Ming Hsieh , Chie-Shaan Su

Pirfenidone is an orally active antifibrotic agent for the treatment of idiopathic pulmonary fibrosis. For designing effective pulmonary drug delivery, microparticle production with controlled particle size is crucial. To select the appropriate supercritical process to meet the goal of particle design of pirfenidone, the solubility of pirfenidone in supercritical carbon dioxide (CO₂) was measured at 313 K to 333 K and 10 MPa to 22 MPa, yielding dissolved mole fractions between 3.90 × 10⁻⁵ and 1.77 × 10⁻³. The measured solubility data were also correlated using four semi-empirical models, with the Chrastil equation providing the best fit. Due to its high solubility, the rapid expansion of supercritical solutions (RESS) was selected for microparticle generation. The effects of extraction temperature, extraction pressure, pre-expansion temperature, and spray distance were investigated. Under the appropriate screening conditions, pirfenidone microparticles with a mean size of 2.5 μm, which fall within the size range suitable for pulmonary drug delivery, were produced. In addition, solid-state characterizations, including PXRD, DSC, and FTIR, confirmed that the crystalline form, thermal behavior, and spectroscopic properties of pirfenidone remained consistent before and after RESS processing. These results demonstrate the feasibility of the RESS process for producing inhalable pirfenidone microparticles and provide fundamental solubility data for supercritical CO₂ processing.

吡非尼酮是一种口服活性抗纤维化药物，用于治疗特发性肺纤维化。为了设计有效的肺给药，控制颗粒大小的微粒生产是至关重要的。为了选择合适的超临界工艺来满足吡非尼酮颗粒设计的目的，在313 K ~ 333 K和10 MPa ~ 22 MPa的条件下，测定了吡非尼酮在超临界二氧化碳中的溶解度，得到的溶解摩尔分数在3.90 × 10⁻5 ~ 1.77 × 10⁻3之间。测量的溶解度数据也使用四种半经验模型进行关联，其中Chrastil方程提供了最佳拟合。由于其高溶解度，选择了快速膨胀超临界溶液（RESS）来产生微粒。考察了萃取温度、萃取压力、预膨胀温度和喷雾距离对萃取效果的影响。在适当的筛选条件下，可制得平均粒径为2.5 μm的吡非尼酮微粒，粒径范围在适合肺部给药的范围内。此外，固态表征，包括PXRD， DSC和FTIR，证实了吡非尼酮的晶体形态，热行为和光谱性质在RESS处理前后保持一致。这些结果证明了RESS工艺生产可吸入性吡非尼酮微粒的可行性，并为超临界CO2处理提供了基本的溶解度数据。

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