Pub Date : 2025-01-28DOI: 10.1016/j.supflu.2025.106537
Yan Ren , Le Zeng , Shaogeng Zhong , Weidong Wu , Yingying Yang , Qiguo Yang
To improve the performance of printed circuit heat exchanger (PCHE) in the supercritical carbon dioxide (SCO2) Brayton cycle system, the mathematic-physical model of the heat exchange unit was established, based on a new-type rectangular microchannel PCHE (RM-PCHE) manufacturing by total-etching technology in this study. And the influence mechanism and laws on the flow and heat transfer of the different fin distributions and shapes were numerically investigate. Results showed average simulation deviations of 0.9 % for outlet temperature and 13.3 % for heat transfer quantity, meeting accuracy requirement. Uniform fin distribution at 10 mm intervals significantly reduced pressure drop and improved comprehensive heat transfer performance by 14.8 %. When elliptical and airfoil fins were selected for the hot-side and cold-side channels, the flow characteristic significantly improved and the heat transfer process became more stable, improving the single-side performance by 15.9 % and 12.3 %, respectively.
{"title":"Optimization of fin for rectangular microchannel printed circuit heat exchanger using supercritical CO2 as working fluid","authors":"Yan Ren , Le Zeng , Shaogeng Zhong , Weidong Wu , Yingying Yang , Qiguo Yang","doi":"10.1016/j.supflu.2025.106537","DOIUrl":"10.1016/j.supflu.2025.106537","url":null,"abstract":"<div><div>To improve the performance of printed circuit heat exchanger (PCHE) in the supercritical carbon dioxide (SCO<sub>2</sub>) Brayton cycle system, the mathematic-physical model of the heat exchange unit was established, based on a new-type rectangular microchannel PCHE (RM-PCHE) manufacturing by total-etching technology in this study. And the influence mechanism and laws on the flow and heat transfer of the different fin distributions and shapes were numerically investigate. Results showed average simulation deviations of 0.9 % for outlet temperature and 13.3 % for heat transfer quantity, meeting accuracy requirement. Uniform fin distribution at 10 mm intervals significantly reduced pressure drop and improved comprehensive heat transfer performance by 14.8 %. When elliptical and airfoil fins were selected for the hot-side and cold-side channels, the flow characteristic significantly improved and the heat transfer process became more stable, improving the single-side performance by 15.9 % and 12.3 %, respectively.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"219 ","pages":"Article 106537"},"PeriodicalIF":3.4,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-21DOI: 10.1016/j.supflu.2025.106523
Xiao-Chang Lu , Biao-Qi Chen , Sheng-Qing Li , Jian-Fei Xu , Ranjith Kumar Kankala , Shi-Bin Wang , Ai-Zheng Chen
The poor water solubility of hesperetin (HST) has impeded its relevant medical applications. To address this problem, the supercritical anti-solvent (SAS) technique was used to prepare HST-polyvinylpyrrolidone (HST-PVP) sub-microparticles. Additionally, the Box-Behnken Design was used to optimize three parameters (temperature, total solute concentration, and pressure) to determine the optimal process conditions, which were determined to be 40 ℃, 5 mg/mL, and 100 bar. The physicochemical properties, drug release, and in vitro anti-cancer efficacy of the designed particles under the optimal conditions were systematically investigated. The drug loading of HST in HST-PVP sub-microparticles was quantified at 12.73 %. The dissolution rate of SAS-treated HST-PVP sub-microparticles was significantly enhanced compared to that of pure HST, leading to a higher anti-cancer efficiency of the HST-PVP sub-microparticles than that of pure HST. These findings indicate that the SAS technique holds significant potential for enhancing the bioavailability of hydrophobic drugs.
{"title":"Preparation of hesperetin-polyvinylpyrrolidone sub-microparticles by supercritical anti-solvent technique for improved anti-cancer efficiency","authors":"Xiao-Chang Lu , Biao-Qi Chen , Sheng-Qing Li , Jian-Fei Xu , Ranjith Kumar Kankala , Shi-Bin Wang , Ai-Zheng Chen","doi":"10.1016/j.supflu.2025.106523","DOIUrl":"10.1016/j.supflu.2025.106523","url":null,"abstract":"<div><div>The poor water solubility of hesperetin (HST) has impeded its relevant medical applications. To address this problem, the supercritical anti-solvent (SAS) technique was used to prepare HST-polyvinylpyrrolidone (HST-PVP) sub-microparticles. Additionally, the Box-Behnken Design was used to optimize three parameters (temperature, total solute concentration, and pressure) to determine the optimal process conditions, which were determined to be 40 ℃, 5 mg/mL, and 100 bar. The physicochemical properties, drug release, and <em>in vitro</em> anti-cancer efficacy of the designed particles under the optimal conditions were systematically investigated. The drug loading of HST in HST-PVP sub-microparticles was quantified at 12.73 %. The dissolution rate of SAS-treated HST-PVP sub-microparticles was significantly enhanced compared to that of pure HST, leading to a higher anti-cancer efficiency of the HST-PVP sub-microparticles than that of pure HST. These findings indicate that the SAS technique holds significant potential for enhancing the bioavailability of hydrophobic drugs.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"219 ","pages":"Article 106523"},"PeriodicalIF":3.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1016/j.supflu.2025.106522
Ana Paula de Souza e Silva , Flávia Cristina Seabra Pires , Maria Caroline Rodrigues Ferreira , Maria Eduarda Ferraz de Carvalho , Letícia Maria Martins Siqueira , Fernando de Freitas Maués de Azevedo , Eduardo Gama Ortiz de Menezes , Raul Nunes Carvalho Junior
The Amazon bioeconomy demands technologies that transform raw materials into high-value bioproducts. This work presents the assembly of a supercritical extractor designed for the Amazon, aiming for efficiency and adaptation of the equipment to the local conditions such as humidity and temperature that provide a directly influence in the phase equilibrium in the CO2 cylinder. Therefore, a gas booster system was developed, eliminating the need for CO2 liquefaction. This innovation simplified operations, reduced costs, and increased energy efficiency. The unit, tested against Soxhlet and commercial SFE methods, achieved 72 % of extraction efficiency using jambu inflorescences, improving product quality. This equipment promotes the use of sustainable resources and supports the Amazon bioeconomy.
{"title":"A new supercritical extraction equipment in the Amazon: Supercritical extractor efficiency upgrade provided by gas booster performance","authors":"Ana Paula de Souza e Silva , Flávia Cristina Seabra Pires , Maria Caroline Rodrigues Ferreira , Maria Eduarda Ferraz de Carvalho , Letícia Maria Martins Siqueira , Fernando de Freitas Maués de Azevedo , Eduardo Gama Ortiz de Menezes , Raul Nunes Carvalho Junior","doi":"10.1016/j.supflu.2025.106522","DOIUrl":"10.1016/j.supflu.2025.106522","url":null,"abstract":"<div><div>The Amazon bioeconomy demands technologies that transform raw materials into high-value bioproducts. This work presents the assembly of a supercritical extractor designed for the Amazon, aiming for efficiency and adaptation of the equipment to the local conditions such as humidity and temperature that provide a directly influence in the phase equilibrium in the CO<sub>2</sub> cylinder. Therefore, a gas booster system was developed, eliminating the need for CO<sub>2</sub> liquefaction. This innovation simplified operations, reduced costs, and increased energy efficiency. The unit, tested against Soxhlet and commercial SFE methods, achieved 72 % of extraction efficiency using jambu inflorescences, improving product quality. This equipment promotes the use of sustainable resources and supports the Amazon bioeconomy.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"219 ","pages":"Article 106522"},"PeriodicalIF":3.4,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1016/j.supflu.2025.106520
Xuwen Wang , Zhifeng Liu , Haoda Ruan , Xinyu Li , Lei Zhang
The rapid advancement of the photovoltaic (PV) industry has elevated the recycling and reuse of decommissioned PV modules to critical challenges, essential for tackling environmental concerns and achieving resource reutilization. To facilitate the efficient layering of PV modules and recovery of valuable materials, this study proposes a PV module degradation and recycling process utilizing supercritical n-butanol. A systematic evaluation was conducted to assess the effects of various factors on the dissolution ratio of PV modules, with an appropriate range of process parameters selected for optimization. A second-order regression model was developed to predict the dissolution ratio of the EVA film. Comparison of actual dissolution ratio with model predictions confirmed the high accuracy of the fitted model. Finally, characterization and elemental analysis of cells recovered from the supercritical process demonstrated the effectiveness of this recycling method, achieving more thorough degradation on the cell surfaces.
{"title":"Employing supercritical n-butanol to remove the EVA film for the delamination of photovoltaic laminated module","authors":"Xuwen Wang , Zhifeng Liu , Haoda Ruan , Xinyu Li , Lei Zhang","doi":"10.1016/j.supflu.2025.106520","DOIUrl":"10.1016/j.supflu.2025.106520","url":null,"abstract":"<div><div>The rapid advancement of the photovoltaic (PV) industry has elevated the recycling and reuse of decommissioned PV modules to critical challenges, essential for tackling environmental concerns and achieving resource reutilization. To facilitate the efficient layering of PV modules and recovery of valuable materials, this study proposes a PV module degradation and recycling process utilizing supercritical n-butanol. A systematic evaluation was conducted to assess the effects of various factors on the dissolution ratio of PV modules, with an appropriate range of process parameters selected for optimization. A second-order regression model was developed to predict the dissolution ratio of the EVA film. Comparison of actual dissolution ratio with model predictions confirmed the high accuracy of the fitted model. Finally, characterization and elemental analysis of cells recovered from the supercritical process demonstrated the effectiveness of this recycling method, achieving more thorough degradation on the cell surfaces.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"219 ","pages":"Article 106520"},"PeriodicalIF":3.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143228558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1016/j.supflu.2025.106521
Yiheng Dou, Yoshito Oshima, Makoto Akizuki
The use of the CO2-expanded liquid method for enhancing the extraction performance of deep eutectic solvents (DES) was evaluated. The extraction of crocin I from gardenia fruits using a DES composed of choline chloride and propylene glycol (1:3) was enhanced by the formation of a CO2-expanded DES. Visualization showed a biphasic system in which the DES-rich phase, and not the CO2 phase, extracted crocin I. Temperature and pressure were the key parameters influencing the effect of CO2 addition, likely due to CO2 solubility in the DES. Kinetic studies using a second-order model showed that CO2 improved both the extraction rate and yield, particularly at higher pressures and lower temperatures. At 40 °C, CO2 addition doubled the extraction rate at 10 MPa and increased the yield by 8 % at 12 MPa.
{"title":"Effect of CO2 addition on crocin i extraction from gardenia fruits using CO2-expanded deep eutectic solvent","authors":"Yiheng Dou, Yoshito Oshima, Makoto Akizuki","doi":"10.1016/j.supflu.2025.106521","DOIUrl":"10.1016/j.supflu.2025.106521","url":null,"abstract":"<div><div>The use of the CO<sub>2</sub>-expanded liquid method for enhancing the extraction performance of deep eutectic solvents (DES) was evaluated. The extraction of crocin I from gardenia fruits using a DES composed of choline chloride and propylene glycol (1:3) was enhanced by the formation of a CO<sub>2</sub>-expanded DES. Visualization showed a biphasic system in which the DES-rich phase, and not the CO<sub>2</sub> phase, extracted crocin I. Temperature and pressure were the key parameters influencing the effect of CO<sub>2</sub> addition, likely due to CO<sub>2</sub> solubility in the DES. Kinetic studies using a second-order model showed that CO<sub>2</sub> improved both the extraction rate and yield, particularly at higher pressures and lower temperatures. At 40 °C, CO<sub>2</sub> addition doubled the extraction rate at 10 MPa and increased the yield by 8 % at 12 MPa.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"219 ","pages":"Article 106521"},"PeriodicalIF":3.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-15DOI: 10.1016/j.supflu.2025.106518
Gizem Zihna , Busra Kilic , Bengisu Topuz , Gulcin Gunal , Halil Murat Aydin
The increasing prevalence of meniscus injuries highlights the critical need for the development of effective repair strategies. Currently, there is ongoing exploration of materials possessing microscopic and macroscopic characteristics akin to authentic meniscus tissue. In this study, meniscus tissue was subjected to a comparative evaluation of two different decellularization techniques which one of these involved conventional decellularization technique; one novel approach involved the utilization of supercritical carbon dioxide (scCO₂) technology on meniscus tissue. All decellularized tissues underwent biochemical, histological, microscopic, mechanical and cytotoxic evaluations. The optimized method, combining physical pretreatment, enzymatic agitation with trypsin agent, and chemical agitation with SDS agent, achieved a remarkable reduction of 82 % in genomic DNA content. Physical pre-treatment in scCO₂ decellularization facilitated enhanced penetration depth with trypsin, resulting in optimal group demonstrating a 76 % reduction in DNA content. While histological examinations and biochemical analyses indicated no alteration in collagen quantities, the conventional decellularization group exhibited a 42 % decline in GAG content, whereas the scCO2 group showed a 58 % decrease. Compressive modulus decreased from 22.8 ± 0.91 MPa in decellularized tissues to 15.26 ± 0.28 MPa in conventionally decellularized scaffold and 14.49 ± 0.48 MPa in scCO2 decellularized tissue, attributed to GAG destruction. Cytotoxicity assessments of the examined tissues revealed cell viability levels exceeding 75 % in both groups. Both approaches demonstrate potential for producing high-quality biomaterials; nevertheless, further research endeavors may lead to enhancements in the extracellular matrix preservation, mechanical characteristics, and facilitation of biological responses using supercritical fluid-based methodologies.
{"title":"Comparative analysis of supercritical-based and chemical-based decellularization technique for meniscus tissue","authors":"Gizem Zihna , Busra Kilic , Bengisu Topuz , Gulcin Gunal , Halil Murat Aydin","doi":"10.1016/j.supflu.2025.106518","DOIUrl":"10.1016/j.supflu.2025.106518","url":null,"abstract":"<div><div>The increasing prevalence of meniscus injuries highlights the critical need for the development of effective repair strategies. Currently, there is ongoing exploration of materials possessing microscopic and macroscopic characteristics akin to authentic meniscus tissue. In this study, meniscus tissue was subjected to a comparative evaluation of two different decellularization techniques which one of these involved conventional decellularization technique; one novel approach involved the utilization of supercritical carbon dioxide (scCO₂) technology on meniscus tissue. All decellularized tissues underwent biochemical, histological, microscopic, mechanical and cytotoxic evaluations. The optimized method, combining physical pretreatment, enzymatic agitation with trypsin agent, and chemical agitation with SDS agent, achieved a remarkable reduction of 82 % in genomic DNA content. Physical pre-treatment in scCO₂ decellularization facilitated enhanced penetration depth with trypsin, resulting in optimal group demonstrating a 76 % reduction in DNA content. While histological examinations and biochemical analyses indicated no alteration in collagen quantities, the conventional decellularization group exhibited a 42 % decline in GAG content, whereas the scCO<sub>2</sub> group showed a 58 % decrease. Compressive modulus decreased from 22.8 ± 0.91 MPa in decellularized tissues to 15.26 ± 0.28 MPa in conventionally decellularized scaffold and 14.49 ± 0.48 MPa in scCO<sub>2</sub> decellularized tissue, attributed to GAG destruction. Cytotoxicity assessments of the examined tissues revealed cell viability levels exceeding 75 % in both groups. Both approaches demonstrate potential for producing high-quality biomaterials; nevertheless, further research endeavors may lead to enhancements in the extracellular matrix preservation, mechanical characteristics, and facilitation of biological responses using supercritical fluid-based methodologies.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"219 ","pages":"Article 106518"},"PeriodicalIF":3.4,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-13DOI: 10.1016/j.supflu.2025.106519
Hugo Andersson Dantas Medeiros , Jean-Patrick Bazile , Filipe Xavier Feitosa , Hosiberto Batista de Sant’Ana , Jean-Luc Daridon
This study investigates the high-pressure phase behavior of synthetic systems formed by the blending of a ternary heavy liquid mixture: 2,2,4,4,6,8,8 heptamethylnonane + dodecylcyclohexane + o-terphenyl – with light gas mixtures. Two different gas mixtures were examined: methane + ethane + propane and methane + ethane + propane + carbon dioxide. Five global compositions were studied for the first gas+liquid system and seven for the second, with temperatures ranging from T = 293.15 K to 373.15 K and pressures up to p = 70 MPa. One hundred and eighteen pressure transitions were measured, including fluid-fluid and solid-fluid transitions. The Peng-Robinson equation of state, with the fully predictive mixing rule PPR78, was used to predict the observed fluid-fluid transitions, showing qualitatively good agreement with experiments.
{"title":"Fluid phase behavior of asymmetric synthetic mixture + gas: Experimental and modeling studies","authors":"Hugo Andersson Dantas Medeiros , Jean-Patrick Bazile , Filipe Xavier Feitosa , Hosiberto Batista de Sant’Ana , Jean-Luc Daridon","doi":"10.1016/j.supflu.2025.106519","DOIUrl":"10.1016/j.supflu.2025.106519","url":null,"abstract":"<div><div>This study investigates the high-pressure phase behavior of synthetic systems formed by the blending of a ternary heavy liquid mixture: 2,2,4,4,6,8,8 heptamethylnonane + dodecylcyclohexane + <em>o</em>-terphenyl – with light gas mixtures. Two different gas mixtures were examined: methane + ethane + propane and methane + ethane + propane + carbon dioxide. Five global compositions were studied for the first gas+liquid system and seven for the second, with temperatures ranging from <em>T</em> = 293.15 K to 373.15 K and pressures up to <em>p</em> = 70 MPa. One hundred and eighteen pressure transitions were measured, including fluid-fluid and solid-fluid transitions. The Peng-Robinson equation of state, with the fully predictive mixing rule PPR78, was used to predict the observed fluid-fluid transitions, showing qualitatively good agreement with experiments.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"219 ","pages":"Article 106519"},"PeriodicalIF":3.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-07DOI: 10.1016/j.supflu.2025.106517
Hsien-Tsung Wu, Yi-Jia Tu, Yu-Xuan Huang, Kim Hoong Ng
Monodisperse nanoparticles of bovine serum albumin (BSA) and lysozyme (LYS) were generated using supercritical assisted atomization (SAA). The impact of several key factors, including the solvent effect, precipitator and saturator temperatures, concentration of protein solutions, and the flow rate ratio of carbon dioxide to protein solutions, on the morphology and size of protein particles was examined. Increasing the ethanol content in the protein solution reduced the particle size, likely due to enhanced secondary atomization by CO2-dissolved aqueous ethanol. Higher precipitator and saturator temperatures increased protein particle size. This effect was attributed to intermolecular aggregation from thermal denaturation. Under optimal conditions, the mean sizes of the BSA and LYS particles were 430 nm and 300 nm, respectively, along with an average process recovery of approximately 60 %. In addition, high-temperature processing enhanced the hydrolytic resistance of protein particles and could be used for the controlled release of drug formulations.
{"title":"Monodisperse protein nanoparticles production by supercritical assisted atomization","authors":"Hsien-Tsung Wu, Yi-Jia Tu, Yu-Xuan Huang, Kim Hoong Ng","doi":"10.1016/j.supflu.2025.106517","DOIUrl":"10.1016/j.supflu.2025.106517","url":null,"abstract":"<div><div>Monodisperse nanoparticles of bovine serum albumin (BSA) and lysozyme (LYS) were generated using supercritical assisted atomization (SAA). The impact of several key factors, including the solvent effect, precipitator and saturator temperatures, concentration of protein solutions, and the flow rate ratio of carbon dioxide to protein solutions, on the morphology and size of protein particles was examined. Increasing the ethanol content in the protein solution reduced the particle size, likely due to enhanced secondary atomization by CO<sub>2</sub>-dissolved aqueous ethanol. Higher precipitator and saturator temperatures increased protein particle size. This effect was attributed to intermolecular aggregation from thermal denaturation. Under optimal conditions, the mean sizes of the BSA and LYS particles were 430 nm and 300 nm, respectively, along with an average process recovery of approximately 60 %. In addition, high-temperature processing enhanced the hydrolytic resistance of protein particles and could be used for the controlled release of drug formulations.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"218 ","pages":"Article 106517"},"PeriodicalIF":3.4,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-04DOI: 10.1016/j.supflu.2024.106509
Oxana N. Fedyaeva, Aleksander P. Grebennikov, Anatoly A. Vostrikov
The paper presents the research results on oxidation of liquid lead (Pb)l and bismuth (Bi)l by high density water-oxygen fluid (ρH2O = 0.91–4.69 and ρO2 = 0.75–2.93 mol/dm3). Time dependences of the pressure were obtained by the method of H2O/O2 fluid injection into the reactor at different temperatures (623–873 K), from which the dependences of the amount of O2 in the reaction mixture were calculated and the oxidation kinetics was described. The results revealed a non-monotonic dependence of the (Pb)l oxidation rate and mechanisms on temperature and H2O/O2 molar ratio, caused by the transition from kinetic to diffusion modes. The oxidation rate of (Bi)l was observed to increase with increasing temperature and is governed by diffusion. The oxidation of (Pb)l at 653–723 K and molar ratio H2O/O2 = 1.45–1.70 was found to lead to the formation of a porous oxide layer consisting of polyhedral Pb3O4 crystals. The oxidation of (Bi)l gives rise to the synthesis of Bi(OH)3 and Bi2O3 in the form of plates, ribbons, and rods exhibiting diverse crystal structures. It is shown that H2O molecules can participate in oxidation of (Pb)l as a catalyst, whereas in the oxidation of (Bi)l they act as the reagent. The results obtained may be useful in developing new approaches to the synthesis of oxide particles using supercritical water fluids, evaluating the stability of catalysts based on variable valence metal oxides, and ensuring the safety of power units.
{"title":"The role of water in the oxidation of lead and bismuth by high-density water-oxygen fluid","authors":"Oxana N. Fedyaeva, Aleksander P. Grebennikov, Anatoly A. Vostrikov","doi":"10.1016/j.supflu.2024.106509","DOIUrl":"10.1016/j.supflu.2024.106509","url":null,"abstract":"<div><div>The paper presents the research results on oxidation of liquid lead (Pb)<sup>l</sup> and bismuth (Bi)<sup>l</sup> by high density water-oxygen fluid (ρ<sub>H2O</sub> = 0.91–4.69 and ρ<sub>O2</sub> = 0.75–2.93 mol/dm<sup>3</sup>). Time dependences of the pressure were obtained by the method of H<sub>2</sub>O/O<sub>2</sub> fluid injection into the reactor at different temperatures (623–873 K), from which the dependences of the amount of O<sub>2</sub> in the reaction mixture were calculated and the oxidation kinetics was described. The results revealed a non-monotonic dependence of the (Pb)<sup>l</sup> oxidation rate and mechanisms on temperature and H<sub>2</sub>O/O<sub>2</sub> molar ratio, caused by the transition from kinetic to diffusion modes. The oxidation rate of (Bi)<sup>l</sup> was observed to increase with increasing temperature and is governed by diffusion. The oxidation of (Pb)<sup>l</sup> at 653–723 K and molar ratio H<sub>2</sub>O/O<sub>2</sub> = 1.45–1.70 was found to lead to the formation of a porous oxide layer consisting of polyhedral Pb<sub>3</sub>O<sub>4</sub> crystals. The oxidation of (Bi)<sup>l</sup> gives rise to the synthesis of Bi(OH)<sub>3</sub> and Bi<sub>2</sub>O<sub>3</sub> in the form of plates, ribbons, and rods exhibiting diverse crystal structures. It is shown that H<sub>2</sub>O molecules can participate in oxidation of (Pb)<sup>l</sup> as a catalyst, whereas in the oxidation of (Bi)<sup>l</sup> they act as the reagent. The results obtained may be useful in developing new approaches to the synthesis of oxide particles using supercritical water fluids, evaluating the stability of catalysts based on variable valence metal oxides, and ensuring the safety of power units.</div></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"218 ","pages":"Article 106509"},"PeriodicalIF":3.4,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-04DOI: 10.1016/j.supflu.2024.106510
Hamed Peyrovedin , Seyed Ali Sajadian , Sara Bahmanzade , Kamiar Zomorodian , Mohammad Khorram
Rifampin is an effective tuberculosis drug. This study examines drug solubility in supercritical carbon dioxide at 308 K to 338 K and 12 MPa to 30 MPa. This study investigates Rifampin solubility using ethanol as a co-solvent. The experimental data is then used to develop a solute-solvent system model using semi-empirical correlations, the Peng-Robinson equation of state, and machine learning models. A study showed that the mole fraction of rifampin without a co-solvent ranges from 0.147 × 10−5 to 1.972 × 10−5. Using ethanol as a co-solvent enhances Rifampin mole fraction, resulting in a range of 1.880 × 10−5 to 1.403 × 10−4. This study shows that ethanol can be used in this particular system as a co-solvent. The findings demonstrate that semi-empirical, equation of state-based, and machine learning methods may accurately determine Rifampin solubility. Moreover, the results indicate that the incorporation of a co-solvent enhances solubility and may facilitate the application of SCF-based micronization techniques, particularly the rapid expansion of supercritical solution (RESS) and other SCF-based methods for nanoparticle production. However, the use of a liquid co-solvent can complicate the recovery of a dry drugs powder.
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