Pub Date : 2024-08-03DOI: 10.1016/j.supflu.2024.106374
Friso G. Versteeg, Guilherme de M.R. Lima, Francesco Picchioni, Pablo Druetta
Expanded polystyrene (ePS) plays an important role in the food packaging industry. However, the foaming process is environmentally unfriendly. A sustainable alternative is dissolving supercritical CO2 (scCO2) in the polystyrene (PS) matrix. Most studies so far were performed at temperatures above the PS glass transition temperature; however, a more general temperature window is desirable. In this work, the solubility of scCO2 in polystyrene was measured at 323 K, 343 K, 363 K and 383 K and pressure up to 130 bar using a magnetic suspension balance (MSB). It was concluded that the solubility of CO2 in PS decreases with temperature and increases with pressure. The Sanchez-Lacombe Equation of State was utilized to estimate the degree of swelling. The model developed was able to derive the experimentally determined solubilities after correction for the swelling. The interaction parameter, k12, turned out to be only a function of temperature. With these results the solubility and swelling of PS in scCO2 can be more accurately assessed for different temperatures and pressures.
发泡聚苯乙烯(ePS)在食品包装行业发挥着重要作用。然而,发泡工艺并不环保。一种可持续的替代方法是在聚苯乙烯(PS)基质中溶解超临界 CO(scCO)。迄今为止,大多数研究都是在高于 PS 玻璃转化温度的条件下进行的;然而,我们需要一个更宽泛的温度窗口。在这项工作中,使用磁悬浮天平 (MSB) 在 323 K、343 K、363 K 和 383 K 以及高达 130 bar 的压力下测量了 scCO 在聚苯乙烯中的溶解度。结果表明,一氧化碳在聚苯乙烯中的溶解度随温度升高而降低,随压力升高而升高。利用 Sanchez-Lacombe 状态方程估算了溶胀程度。在对溶胀进行修正后,所建立的模型能够推导出实验测定的溶解度。结果表明,相互作用参数 k 只是温度的函数。有了这些结果,就可以更准确地评估 PS 在不同温度和压力下在 scCO 中的溶解度和溶胀度。
{"title":"Solubility of supercritical CO2 in polystyrene","authors":"Friso G. Versteeg, Guilherme de M.R. Lima, Francesco Picchioni, Pablo Druetta","doi":"10.1016/j.supflu.2024.106374","DOIUrl":"10.1016/j.supflu.2024.106374","url":null,"abstract":"<div><p>Expanded polystyrene (ePS) plays an important role in the food packaging industry. However, the foaming process is environmentally unfriendly. A sustainable alternative is dissolving supercritical CO<sub>2</sub> (scCO<sub>2</sub>) in the polystyrene (PS) matrix. Most studies so far were performed at temperatures above the PS glass transition temperature; however, a more general temperature window is desirable. In this work, the solubility of scCO<sub>2</sub> in polystyrene was measured at 323 K, 343 K, 363 K and 383 K and pressure up to 130 bar using a magnetic suspension balance (MSB). It was concluded that the solubility of CO<sub>2</sub> in PS decreases with temperature and increases with pressure. The Sanchez-Lacombe Equation of State was utilized to estimate the degree of swelling. The model developed was able to derive the experimentally determined solubilities after correction for the swelling. The interaction parameter, k<sub>12</sub>, turned out to be only a function of temperature. With these results the solubility and swelling of PS in scCO<sub>2</sub> can be more accurately assessed for different temperatures and pressures.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"213 ","pages":"Article 106374"},"PeriodicalIF":3.4,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0896844624002092/pdfft?md5=216ec0599b69d6363ae8609ef674a44d&pid=1-s2.0-S0896844624002092-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141915325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-26DOI: 10.1016/j.supflu.2024.106349
Paulina Falletti , María F. Barrera Vázquez , Pedro H. Santos , Luiz G. Gonçalves Rodrigues , Marcelo Lanza , Raquel E. Martini , Laura R. Comini
Flaveria bidentis is an invasive plant containing Sulfated Flavonoids (SFs) with therapeutic potential. The extraction of these compounds would add value to the biomass generated during weeding. This work reports the optimization of the pretreatment of F. bidentis leaves with supercritical CO2 (P-SC-CO2) prior extraction of these compounds using subcritical water extraction. The combined effect of different levels of the three factors on P-SC-CO2, Time, Pressure and Depressurization rate, was investigated with Response Surface Methodology. The optimal pretreatment conditions were as follows: Time = 30 min, Pressure = 30 MPa and Depressurization rate = 2 kg CO2/h. Under these conditions, 72.45 ± 0.99 mg of totals SFs/100 g of leaves was recovered, practically doubling total SFs extraction yield in the absence of pretreatment. In addition, the structural damage caused by P-SC-CO2 on the leaves was detected using Scanning Electron Microscopy.
{"title":"Optimization of supercritical carbon dioxide pretreatment of Flaveria bidentis leaves prior extraction of sulfated flavonoids with subcritical water","authors":"Paulina Falletti , María F. Barrera Vázquez , Pedro H. Santos , Luiz G. Gonçalves Rodrigues , Marcelo Lanza , Raquel E. Martini , Laura R. Comini","doi":"10.1016/j.supflu.2024.106349","DOIUrl":"10.1016/j.supflu.2024.106349","url":null,"abstract":"<div><p><em>Flaveria bidentis</em> is an invasive plant containing Sulfated Flavonoids (SFs) with therapeutic potential. The extraction of these compounds would add value to the biomass generated during weeding. This work reports the optimization of the pretreatment of <em>F. bidentis</em> leaves with supercritical CO<sub>2</sub> (P-SC-CO<sub>2</sub>) prior extraction of these compounds using subcritical water extraction. The combined effect of different levels of the three factors on P-SC-CO<sub>2</sub>, Time, Pressure and Depressurization rate, was investigated with Response Surface Methodology. The optimal pretreatment conditions were as follows: Time = 30 min, Pressure = 30 MPa and Depressurization rate = 2 kg CO<sub>2</sub>/h. Under these conditions, 72.45 ± 0.99 mg of totals SFs/100 g of leaves was recovered, practically doubling total SFs extraction yield in the absence of pretreatment. In addition, the structural damage caused by P-SC-CO<sub>2</sub> on the leaves was detected using Scanning Electron Microscopy.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"213 ","pages":"Article 106349"},"PeriodicalIF":3.4,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-26DOI: 10.1016/j.supflu.2024.106369
Lucas Cantão Freitas , Manoel Benedito Sousa Cantão , Vanessa Souza Carvalho , Rogério Willian Silva dos Santos , Marcos Lúcio Corazza , Maria Lucia Masson
Compressed n-propane extraction (CPE) was applied to umari fruit (Poraqueiba sericea Tul.) pulp to obtain an oil rich in high added-value components. CPE was performed at different temperatures and flow rate, which was compared to conventional extraction (Soxhlet). The oils were analyzed for global yields, fatty acid composition, β-carotene content, antioxidant activity, total phenolics content (TPC) total flavonoids (TF), and thermal behavior. The highest extraction yield (29.2 wt%) was obtained with CPE at 80 °C and 3 mL.min−1, being higher than that obtained by Soxhlet. The flow rate variation had a significant effect (p < 0.05) on the oil extraction yield, while the temperature had a negative effect. The umari oil obtained by CPE emerges as a rich source of oleic acid (omega-9) and β-carotene (vitamin A precursor), with potential to be applied in various industrial segments and inserted into the Amazon bioeconomy scenario.
对乌梅果(Poraqueiba sericea Tul.)果肉进行压缩正丙烷萃取(CPE),以获得富含高附加值成分的油脂。正丙烷萃取在不同的温度和流速下进行,并与传统萃取(索氏提取法)进行了比较。对油的总产量、脂肪酸组成、β-胡萝卜素含量、抗氧化活性、总酚含量(TPC)、总黄酮含量(TF)和热行为进行了分析。CPE 在 80 °C 和 3 mL.min-1 条件下的提取率最高(29.2 wt%),高于索氏提取法。流速变化对萃取率有显著影响(p < 0.05),而温度则有负面影响。通过 CPE 获得的乌玛里油含有丰富的油酸(omega-9)和 β-胡萝卜素(维生素 A 前体),具有应用于各种工业领域并融入亚马逊生物经济情景的潜力。
{"title":"Compressed n-propane extraction of umari pulp oil: A rich Amazon source of β-carotene and omega-9","authors":"Lucas Cantão Freitas , Manoel Benedito Sousa Cantão , Vanessa Souza Carvalho , Rogério Willian Silva dos Santos , Marcos Lúcio Corazza , Maria Lucia Masson","doi":"10.1016/j.supflu.2024.106369","DOIUrl":"10.1016/j.supflu.2024.106369","url":null,"abstract":"<div><p>Compressed <em>n</em>-propane extraction (CPE) was applied to umari fruit (<em>Poraqueiba sericea</em> Tul.) pulp to obtain an oil rich in high added-value components. CPE was performed at different temperatures and flow rate, which was compared to conventional extraction (Soxhlet). The oils were analyzed for global yields, fatty acid composition, β-carotene content, antioxidant activity, total phenolics content (TPC) total flavonoids (TF), and thermal behavior. The highest extraction yield (29.2 wt%) was obtained with CPE at 80 °C and 3 mL.min<sup>−1</sup>, being higher than that obtained by Soxhlet. The flow rate variation had a significant effect (<em>p</em> < 0.05) on the oil extraction yield, while the temperature had a negative effect. The umari oil obtained by CPE emerges as a rich source of oleic acid (omega-9) and β-carotene (vitamin A precursor), with potential to be applied in various industrial segments and inserted into the Amazon bioeconomy scenario.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"213 ","pages":"Article 106369"},"PeriodicalIF":3.4,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-26DOI: 10.1016/j.supflu.2024.106368
L.I. Granone , F.A. Sánchez , P. Hegel , S. Pereda
This work introduces a pumpless high-pressure Soxhlet cross-current solid-liquid extraction method using liquid CO2 and hydrated ethanol for studying the decaffeination of yerba mate. By combining experimental results with thermodynamic modelling, a comprehensive evaluation of the impact of the co-solvent composition is achieved. It is observed that an ethanol/water mixture with a specific composition of 85 wt% is optimal under mild operating conditions (283 K and 4.5 MPa) for extracting caffeine from chopped yerba mate leaves with a negligible co-extraction of caffeoyl derivative antioxidants. The obtained selectivity, together with the phase equilibrium simulation, provide evidence of the significant potential of liquid CO2 extraction as a decaffeination alternative for yerba mate. Thus, high-pressure Soxhlet extraction serves as simple technique to access valuable experimental information with potential for the conceptual design of further scalable semi-continuous processes.
本研究介绍了一种使用液态二氧化碳和水合乙醇的无泵高压索氏跨流固液萃取法,用于研究耶巴马黛茶的脱咖啡因作用。通过将实验结果与热力学模型相结合,实现了对助溶剂成分影响的全面评估。研究发现,在温和的操作条件下(283 K 和 4.5 MPa),乙醇/水混合物的特定成分为 85 wt%,是从切碎的耶巴马黛茶叶中萃取咖啡因的最佳选择,同时咖啡因酰衍生物抗氧化剂的共萃取量可以忽略不计。所获得的选择性和相平衡模拟结果证明,液态二氧化碳萃取作为耶巴马黛茶的脱咖啡因替代品具有巨大潜力。因此,高压索氏提取是获取宝贵实验信息的简单技术,具有进一步设计可扩展半连续工艺的潜力。
{"title":"Decaffeination of yerba mate (Ilex paraguariensis) by pressurized liquid CO2 extraction: A feasible process?","authors":"L.I. Granone , F.A. Sánchez , P. Hegel , S. Pereda","doi":"10.1016/j.supflu.2024.106368","DOIUrl":"10.1016/j.supflu.2024.106368","url":null,"abstract":"<div><p>This work introduces a pumpless high-pressure Soxhlet cross-current solid-liquid extraction method using liquid CO<sub>2</sub> and hydrated ethanol for studying the decaffeination of yerba mate. By combining experimental results with thermodynamic modelling, a comprehensive evaluation of the impact of the co-solvent composition is achieved. It is observed that an ethanol/water mixture with a specific composition of 85 wt% is optimal under mild operating conditions (283 K and 4.5 MPa) for extracting caffeine from chopped yerba mate leaves with a negligible co-extraction of caffeoyl derivative antioxidants. The obtained selectivity, together with the phase equilibrium simulation, provide evidence of the significant potential of liquid CO<sub>2</sub> extraction as a decaffeination alternative for yerba mate. Thus, high-pressure Soxhlet extraction serves as simple technique to access valuable experimental information with potential for the conceptual design of further scalable semi-continuous processes.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"213 ","pages":"Article 106368"},"PeriodicalIF":3.4,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.1016/j.supflu.2024.106354
Victor Saldanha Carvalho , Francisco Manuel Barrales , Luiz Henrique Fasolin , Juliane Viganó , Julian Martínez
The concentration of oxygenated monoterpenes (oxyterpenes) in orange peel oil by supercritical fluid adsorption (SFA) was investigated varying pressure (10–24 MPa) and temperature (40–60 ºC) and using silica aerogels as adsorbent. Dynamic solubility experiments were conducted to obtain the solubility of the monoterpenes in supercritical CO2, revealing that it increases with pressure regardless of temperature. For SFA, 10 MPa and 60 ºC was the most appropriate condition to concentrate oxyterpenes, leading to the lowest solubility of oxyterpenes and highlighting the advantage of lower densities for SFA’s selectivity. Furthermore, this condition yielded the highest concentration factors for oxyterpenes (4.3 for linalool and 6.5 for α-terpineol) within the 80–90 min interval. These findings contribute with valuable insights to SFA processes to concentrate oxyterpenes from orange peel oil, which has the potential to enhance the market value and functionality of this important product from citrus industries.
{"title":"Concentration of the oxyterpenes linalool and α-terpineol in orange peel oil by supercritical fluid adsorption","authors":"Victor Saldanha Carvalho , Francisco Manuel Barrales , Luiz Henrique Fasolin , Juliane Viganó , Julian Martínez","doi":"10.1016/j.supflu.2024.106354","DOIUrl":"10.1016/j.supflu.2024.106354","url":null,"abstract":"<div><p>The concentration of oxygenated monoterpenes (oxyterpenes) in orange peel oil by supercritical fluid adsorption (SFA) was investigated varying pressure (10–24 MPa) and temperature (40–60 ºC) and using silica aerogels as adsorbent. Dynamic solubility experiments were conducted to obtain the solubility of the monoterpenes in supercritical CO<sub>2</sub>, revealing that it increases with pressure regardless of temperature. For SFA, 10 MPa and 60 ºC was the most appropriate condition to concentrate oxyterpenes, leading to the lowest solubility of oxyterpenes and highlighting the advantage of lower densities for SFA’s selectivity. Furthermore, this condition yielded the highest concentration factors for oxyterpenes (4.3 for linalool and 6.5 for α-terpineol) within the 80–90 min interval. These findings contribute with valuable insights to SFA processes to concentrate oxyterpenes from orange peel oil, which has the potential to enhance the market value and functionality of this important product from citrus industries.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"213 ","pages":"Article 106354"},"PeriodicalIF":3.4,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The catalytic oxidation of benzene with nitrous oxide (N2O) over ZSM-5 zeolite has been carried out in a continuous-flow reactor under supercritical conditions and compared with the results of the gas-phase reaction. Aromatic substrates and nitrous oxide under the conditions of supercritical experiments (300–435 °C, 6.0–18.0 MPa) are both reagents and the supercritical medium. It has been established that the productivity of the supercritical oxidation of benzene into phenol significantly exceeds the productivity of the gas-phase process owing to the limited reversible deactivation of the catalyst under supercritical conditions and the in situ removal of the coke precursors by the dense reaction medium. In addition, it has been demonstrated that a successful in situ regeneration of the deactivated oxidation catalyst can be carried out during the transition from gas-phase reaction conditions to supercritical conditions in one experiment.
{"title":"Oxidation of benzene with N2O on ZSM-5 zeolite: A comparison of gas-phase and supercritical conditions","authors":"V.I. Bogdan , V.L. Zholobenko , T.V. Bogdan , A.L. Kustov , A.E. Koklin , I.I. Mishanin , N.V. Mashchenko , S.E. Bogorodskiy","doi":"10.1016/j.supflu.2024.106355","DOIUrl":"10.1016/j.supflu.2024.106355","url":null,"abstract":"<div><p>The catalytic oxidation of benzene with nitrous oxide (N<sub>2</sub>O) over ZSM-5 zeolite has been carried out in a continuous-flow reactor under supercritical conditions and compared with the results of the gas-phase reaction. Aromatic substrates and nitrous oxide under the conditions of supercritical experiments (300–435 °C, 6.0–18.0 MPa) are both reagents and the supercritical medium. It has been established that the productivity of the supercritical oxidation of benzene into phenol significantly exceeds the productivity of the gas-phase process owing to the limited reversible deactivation of the catalyst under supercritical conditions and the <em>in situ</em> removal of the coke precursors by the dense reaction medium. In addition, it has been demonstrated that a successful in situ regeneration of the deactivated oxidation catalyst can be carried out during the transition from gas-phase reaction conditions to supercritical conditions in one experiment.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"213 ","pages":"Article 106355"},"PeriodicalIF":3.4,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-20DOI: 10.1016/j.supflu.2024.106357
D.I. Kamalova, M.Kh. Salakhov
An approach to predict the gas permeability of membrane polymers after supercritical CO2 treatment is proposed. The approach is based on the connection of the temperatures of secondary relaxation transitions with the effective sizes of mobile free volume elements in the polymers. The correlation between permeability of nitrogen and effective sizes of mobile holes for a set of polymers is established. The effect of supercritical CO2 on the nitrogen permeability of polycarbonate, polysulfone, polyvinylbutyral is analyzed by FTIR spectroscopy of low-molecular weight conformationally-inhomogeneous compounds introduced in the polymers. Membranes were exposed at 40 MPa and 333 K for 4 h through static treatment and dynamic treatment separately. For polyvinylbutyral, the nitrogen permeability did not change after supercritical CO2 modification while for polysulphone, the effective volume of mobile holes increased, but the nitrogen permeability decreased. For polycarbonate after supercritical CO2, the effective volume of mobile holes and the nitrogen permeability increased.
本文提出了一种预测膜聚合物经超临界 CO 处理后气体渗透性的方法。该方法基于二次弛豫转变温度与聚合物中可移动自由体积元素有效尺寸之间的联系。建立了一组聚合物的氮渗透性与移动孔有效尺寸之间的相关性。通过对聚合物中引入的低分子量构象均一化合物的傅立叶变换红外光谱分析了超临界 CO 对聚碳酸酯、聚砜和聚乙烯醇缩丁醛的氮渗透性的影响。分别通过静态处理和动态处理,将膜暴露在 40 兆帕和 333 K 的环境中 4 小时。对于聚乙烯醇缩丁醛,超临界 CO 改性后氮渗透性没有变化;而对于聚砜,移动孔的有效体积增加了,但氮渗透性降低了。聚碳酸酯经过超临界 CO 改性后,移动孔的有效体积和氮渗透率都有所增加。
{"title":"Permeability of porous membrane polymers modified by supercritical carbon dioxide","authors":"D.I. Kamalova, M.Kh. Salakhov","doi":"10.1016/j.supflu.2024.106357","DOIUrl":"10.1016/j.supflu.2024.106357","url":null,"abstract":"<div><p>An approach to predict the gas permeability of membrane polymers after supercritical CO<sub>2</sub> treatment is proposed. The approach is based on the connection of the temperatures of secondary relaxation transitions with the effective sizes of mobile free volume elements in the polymers. The correlation between permeability of nitrogen and effective sizes of mobile holes for a set of polymers is established. The effect of supercritical CO<sub>2</sub> on the nitrogen permeability of polycarbonate, polysulfone, polyvinylbutyral is analyzed by FTIR spectroscopy of low-molecular weight conformationally-inhomogeneous compounds introduced in the polymers. Membranes were exposed at 40 MPa and 333 K for 4 h through static treatment and dynamic treatment separately. For polyvinylbutyral, the nitrogen permeability did not change after supercritical CO<sub>2</sub> modification while for polysulphone, the effective volume of mobile holes increased, but the nitrogen permeability decreased. For polycarbonate after supercritical CO<sub>2</sub>, the effective volume of mobile holes and the nitrogen permeability increased.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"213 ","pages":"Article 106357"},"PeriodicalIF":3.4,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-20DOI: 10.1016/j.supflu.2024.106351
C. Bouhallas , A. Abdallah el hadj , Y. Ammi , A. Belghait
In this paper, a new semi-empirical density-based model was developed to correlate drug compounds solubility in supercritical carbon dioxide (SC-CO2) as a function of temperature and density of supercritical carbon dioxide. The proposed approach has successfully predicted the solubility of 282 pharmaceutical compounds accounting for 7469 experimental data points collected from literature published between 1994 and 2024. Several statistical metrics, including average absolute relative deviation (AARD=7.24 %), coefficient of correlation (R=0.9987), and coefficient of determination (R2=0.994) were used to validate the reliability of the proposed model and compared with twenty existing density-based models. The overall results demonstrate the accuracy of the proposed model and its suitability for the correlation of solubility.
{"title":"Assessment of new semi-empirical density based model for prediction the solubility of pharmaceutical components in supercritical carbon dioxide","authors":"C. Bouhallas , A. Abdallah el hadj , Y. Ammi , A. Belghait","doi":"10.1016/j.supflu.2024.106351","DOIUrl":"10.1016/j.supflu.2024.106351","url":null,"abstract":"<div><p>In this paper, a new semi-empirical density-based model was developed to correlate drug compounds solubility in supercritical carbon dioxide (SC-CO<sub>2</sub>) as a function of temperature and density of supercritical carbon dioxide. The proposed approach has successfully predicted the solubility of 282 pharmaceutical compounds accounting for 7469 experimental data points collected from literature published between 1994 and 2024. Several statistical metrics, including average absolute relative deviation (AARD=7.24 %), coefficient of correlation (R=0.9987), and coefficient of determination (R<sup>2</sup>=0.994) were used to validate the reliability of the proposed model and compared with twenty existing density-based models. The overall results demonstrate the accuracy of the proposed model and its suitability for the correlation of solubility.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"213 ","pages":"Article 106351"},"PeriodicalIF":3.4,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-18DOI: 10.1016/j.supflu.2024.106347
Lucas Cantão Freitas , Flávia Cristina Seabra Pires , Tiago Costa de Araújo , Raul Nunes de Carvalho Junior
Sequential extraction (SE) using supercritical CO2 plus ethanol was applied to separate resin from bacuri fruit shell, where process parameters such as particle size, pressure and cosolvent use were studied. The extracts obtained were also analyzed for phenolic compounds and antioxidant capacity. The extraction results showed that SE was able to separate the resin, which is the first report described in the literature, resulting in a patent. Furthermore, the smaller particle size (0.25 mm) showed the higher extraction rates, providing good yields of lipid extracts (up to 10.09 wt%) and ethanolic extracts (up to 13.78 wt%). The extracts presented good levels of phenolic compounds, which was associated with its high antioxidant capacity. Thus, the application of SE added value to bacuri fruit shell, enabling new strands for potential applications in the food, pharmaceutical and cosmetic industries, placing this by-product in the Amazon bioeconomy scenario.
{"title":"Sequential extraction as a pioneering method to separate resin from bacuri fruit shell","authors":"Lucas Cantão Freitas , Flávia Cristina Seabra Pires , Tiago Costa de Araújo , Raul Nunes de Carvalho Junior","doi":"10.1016/j.supflu.2024.106347","DOIUrl":"10.1016/j.supflu.2024.106347","url":null,"abstract":"<div><p>Sequential extraction (SE) using supercritical CO<sub>2</sub> plus ethanol was applied to separate resin from bacuri fruit shell, where process parameters such as particle size, pressure and cosolvent use were studied. The extracts obtained were also analyzed for phenolic compounds and antioxidant capacity. The extraction results showed that SE was able to separate the resin, which is the first report described in the literature, resulting in a patent. Furthermore, the smaller particle size (0.25 mm) showed the higher extraction rates, providing good yields of lipid extracts (up to 10.09 wt%) and ethanolic extracts (up to 13.78 wt%). The extracts presented good levels of phenolic compounds, which was associated with its high antioxidant capacity. Thus, the application of SE added value to bacuri fruit shell, enabling new strands for potential applications in the food, pharmaceutical and cosmetic industries, placing this by-product in the Amazon bioeconomy scenario.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"213 ","pages":"Article 106347"},"PeriodicalIF":3.4,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141850849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-18DOI: 10.1016/j.supflu.2024.106356
Hadi Share Mohammadi, Ali Haghighi Asl, Maryam Khajenoori
This action described the experimental equilibrium solubility of aprepitant (APT), an antiemetic drug for chemotherapy, in subcritical water (SW) with/without ethanol as co-solvent, acquired through a static method between 298.15 and 393.15 K and 0–15 % (w/w) of ethanol and the constant pressure of 10 bar. The mole fraction of APT was obtained in the range of 0.39×10−4 to 9.10×10−4 while its mole fraction by cosolvent varied from 0.75×10−4 to 22.98×10−4. The obtained results represented the significant effect of solvent temperature on the solubility of APT. For both studied systems, the solubility data was successfully correlated with two well-known semi-empirical temperature-based models, namely the linear and modified Apelblat models. Results from applying statistical criteria exhibited that the modified Apelblat model had the highest accordance with experimental data. Finally, using the obtained correlation results, the apparent thermodynamic analysis including enthalpy, entropy, and Gibbs free energy of dissolution for APT dissolved in SW was obtained.
{"title":"Experimental analysis and modeling of aprepitant (an antiemetic drug for chemotherapy) solubility in subcritical water with/without co-solvent","authors":"Hadi Share Mohammadi, Ali Haghighi Asl, Maryam Khajenoori","doi":"10.1016/j.supflu.2024.106356","DOIUrl":"10.1016/j.supflu.2024.106356","url":null,"abstract":"<div><p>This action described the experimental equilibrium solubility of aprepitant (APT), an antiemetic drug for chemotherapy, in subcritical water (SW) with/without ethanol as co-solvent, acquired through a static method between 298.15 and 393.15 K and 0–15 % (w/w) of ethanol and the constant pressure of 10 bar. The mole fraction of APT was obtained in the range of 0.39×10<sup>−4</sup> to 9.10×10<sup>−4</sup> while its mole fraction by cosolvent varied from 0.75×10<sup>−4</sup> to 22.98×10<sup>−4</sup>. The obtained results represented the significant effect of solvent temperature on the solubility of APT. For both studied systems, the solubility data was successfully correlated with two well-known semi-empirical temperature-based models, namely the linear and modified Apelblat models. Results from applying statistical criteria exhibited that the modified Apelblat model had the highest accordance with experimental data. Finally, using the obtained correlation results, the apparent thermodynamic analysis including enthalpy, entropy, and Gibbs free energy of dissolution for APT dissolved in SW was obtained.</p></div>","PeriodicalId":17078,"journal":{"name":"Journal of Supercritical Fluids","volume":"213 ","pages":"Article 106356"},"PeriodicalIF":3.4,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141769183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}