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Falls as a Predictor of Future Dementia in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis 跌倒是中老年人未来痴呆的预测因素:一项系统回顾和荟萃分析。
IF 3.8 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1016/j.jamda.2025.106089
Juncai Li MS, Zhe Meng MS, Shuangxin Zhang PhD, Longjie Wei MS, Qirui Zhang MS, Yijia Lin MS, Bonolo William MS, Xiuling Zhou MBBS

Objectives

To systematically review and quantitatively synthesize evidence on the predictive role of falls for future dementia in middle-aged and older adults.

Design

Systematic review and meta-analysis.

Setting and Participants

Middle-aged and older adults without dementia (aged ≥40 years).

Methods

Systematically retrieved literature from 4 English-language databases—PubMed, Embase, Web of Science, and the Cochrane Library—from inception to July 1, 2025. Prospective and retrospective cohort studies investigating the association between falls and future development of dementia were included. Study quality was assessed using the Newcastle-Ottawa Scale. A random-effects model was applied using Stata 17.0 software to conduct a pooled analysis of the incidence of dementia in middle-aged and older adults (≥40 years) with a history of falls, as well as the strength of the association between falls and future dementia [adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs)].

Results

A total of 7 studies were included, of which 5 were included in the meta-analysis, comprising a total of 2,922,624 participants. Results indicate that among 1,246,410 middle-aged and older adults with a history of falls, the pooled incidence of future dementia was 11.6% (95% CI, 4.2%–19.0%; I2 = 99.8%). Among older adults (≥60 years), the pooled incidence was 12.3% (95% CI, 4.7%–20.0%; I2 = 99.8%). Both single falls (aHR, 1.20; 95% CI, 1.07–1.36) and multiple falls (aHR, 1.74; 95% CI, 1.53–1.98) increased the risk of future all-cause dementia, and multiple falls were a more robust predictor of future dementia. Collectively, the results indicate that the frequency of falls exhibits a dose-response relationship with dementia risk.

Conclusions and Implications

This study demonstrates that multiple falls are a significant predictor of future dementia and highlights the importance of fall frequency. Recurrent falls may serve as a potential clinical marker for identifying individuals at higher risk. Clinicians should maintain heightened vigilance for cognitive decline in middle-aged and older adults with a history of recurrent falls to facilitate early detection of dementia. Given the limited evidence base and high heterogeneity, further high-quality research is warranted to clarify this association and support preventive strategies in aging populations.
目的:系统回顾和定量综合跌倒对中老年人未来痴呆的预测作用的证据。设计:系统回顾和荟萃分析。环境和参与者:无痴呆的中老年人(年龄≥40岁)。方法:系统检索4个英文数据库(pubmed、Embase、Web of Science和Cochrane library)自成立至2025年7月1日的文献。包括前瞻性和回顾性队列研究,调查跌倒与痴呆未来发展之间的关系。采用纽卡斯尔-渥太华量表评估研究质量。采用Stata 17.0软件采用随机效应模型,对有跌倒史的中老年人(≥40岁)的痴呆发病率以及跌倒与未来痴呆之间的关联强度(调整风险比[aHRs]和95%置信区间[ci])进行汇总分析。结果:共纳入7项研究,其中5项纳入meta分析,共纳入2,922,624名受试者。结果显示,在1,246,410名有跌倒史的中老年人中,未来痴呆的总发病率为11.6% (95% CI, 4.2%-19.0%; I2 = 99.8%)。在老年人(≥60岁)中,合并发病率为12.3% (95% CI, 4.7%-20.0%; I2 = 99.8%)。单次跌倒(aHR, 1.20; 95% CI, 1.07-1.36)和多次跌倒(aHR, 1.74; 95% CI, 1.53-1.98)都增加了未来全因痴呆的风险,多次跌倒是未来痴呆的更可靠的预测因子。总的来说,结果表明跌倒的频率与痴呆风险呈剂量反应关系。结论和意义:本研究表明,多次跌倒是未来痴呆的重要预测因素,并强调了跌倒频率的重要性。复发性跌倒可作为识别高危人群的潜在临床标志。临床医生应对有反复跌倒史的中老年人的认知能力下降保持高度警惕,以促进早期发现痴呆。鉴于有限的证据基础和高度的异质性,需要进一步的高质量研究来澄清这种关联,并支持老年人的预防策略。
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引用次数: 0
Analgesic Stewardship After Hip Fracture: An Urgent Call to Action. 髋部骨折后的镇痛管理:紧急呼吁采取行动。
IF 3.8 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1016/j.jamda.2026.106116
Vincent E S Allot, Benjamin H L Harris, Michael B Fertleman, Louis J Koizia
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引用次数: 0
Factors Associated With Initial Type of Long-Term Services and Supports Among Dual-Eligible Beneficiaries. 双重资格受益人中与初始类型长期服务和支持相关的因素。
IF 3.8 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-05 DOI: 10.1016/j.jamda.2026.106136
Kun-Woo R Kim, David G Stevenson, Jennifer Kim, Chanee D Fabius, Laura M Keohane

Objective: To examine the association between individual characteristics and type of initial long-term services and supports (LTSS) among older adults receiving Medicaid home- and community-based services (HCBS) or nursing home (NH) care.

Design: Cohort study of traditional Medicare beneficiaries surveyed between 2002 and 2009 linked with Medicare and Medicaid administrative files through 2018.

Setting and participants: The study population includes 581 dual-eligible individuals aged ≥65 at the time of initial LTSS use. Study population was predominantly Black (67.1%), female (69.0%), and with a household income below $15,000/year (78.3%).

Methods: Initial HCBS and long-term NH use were identified using Medicaid data and Minimum Data Set (MDS) nursing home assessments. Sociodemographic factors were identified using the Southern Community Cohort Study (SCCS) survey dataset. Chronic conditions and prior health care use were identified using traditional Medicare claims. A multivariate logistic model predicted whether individuals initiated LTSS with HCBS use, adjusting for individual-level covariates and state and year fixed effects.

Results: Half of the sample (N = 291) initiated LTSS with HCBS and the other half (N = 290) initiated with NH use between 2008 and 2018. Factors associated with a higher likelihood of initiating LTSS with HCBS included Black race (marginal effect [ME], 0.13; 95% CI, 0.05-0.21) and female sex (ME, 0.19; 95% CI, 0.12-0.26). Factors associated with higher likelihood of initiating LTSS with NH instead of HCBS included older age, Alzheimer's disease and related dementias (ADRD) diagnosis, recent hospitalization, and higher education levels. Among individuals with ADRD, several factors-Black race, living with others, and prior emergency room use-were associated with higher likelihood of initiating LTSS with HCBS and prior hospitalization was associated with initial NH use.

Conclusion and implications: Among dual-eligible older adults initiating LTSS, factors related to more complex medical needs were associated with a higher likelihood of NH use rather than HCBS use as their initial LTSS option.

目的:探讨在接受医疗补助家庭和社区服务(HCBS)或疗养院(NH)护理的老年人中,个体特征与初始长期服务和支持(LTSS)类型之间的关系。设计:对2002年至2009年间接受调查的传统医疗保险受益人进行队列研究,并将其与医疗保险和医疗补助计划的行政文件联系到2018年。环境和参与者:研究人群包括581名首次使用LTSS时年龄≥65岁的双重条件个体。研究人群主要是黑人(67.1%),女性(69.0%),家庭收入低于15,000美元/年(78.3%)。方法:使用医疗补助数据和最小数据集(MDS)养老院评估确定初始HCBS和长期NH使用情况。使用南方社区队列研究(SCCS)调查数据集确定社会人口因素。使用传统的医疗保险索赔来确定慢性病和先前的医疗保健使用情况。一个多变量逻辑模型预测了使用HCBS的个体是否开始LTSS,调整了个体水平的协变量和状态和年份固定效应。结果:一半的样本(N = 291)在2008年至2018年期间开始使用HCBS进行LTSS,另一半(N = 290)开始使用NH。与HCBS启动LTSS的较高可能性相关的因素包括黑人种族(边际效应[ME], 0.13; 95% CI, 0.05-0.21)和女性(ME, 0.19; 95% CI, 0.12-0.26)。与NH而非HCBS引发LTSS的可能性较高相关的因素包括年龄较大、阿尔茨海默病和相关痴呆(ADRD)诊断、近期住院和高等教育水平。在患有ADRD的个体中,有几个因素——黑人种族、与他人同住、以前使用过急诊室——与HCBS启动LTSS的可能性较高有关,而以前住院与初始NH使用有关。结论和意义:在开始LTSS的双重资格老年人中,与更复杂的医疗需求相关的因素与NH使用的可能性相关,而不是HCBS作为他们最初的LTSS选择。
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引用次数: 0
The Prevalence and Impact of Vaccination Programs: Differences Between Nursing Homes and Assisted Living Communities. 疫苗接种计划的流行和影响:养老院和辅助生活社区之间的差异。
IF 3.8 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-04 DOI: 10.1016/j.jamda.2025.106107
Kennedy J Berner, Patrick O Mese, John R Bowblis, Robert Applebaum

Objectives: To compare the prevalence of vaccination programs between nursing homes (NHs) and assisted living communities (ALs) and examine how these programs relate to perceived hospitalization risk and temporary admission suspensions due to outbreaks.

Design: Descriptive analysis of facility-level survey data from the 2023 Ohio Biennial Survey of Long-Term Care Facilities, which has a >90% response rate.

Setting and participants: All licensed NHs and ALs in Ohio were surveyed and answered questions related to vaccination programs (n = 736; n = 623).

Methods: Three measures were analyzed: presence of a vaccination program for 7 vaccine-preventable illnesses [influenza; COVID-19; respiratory syncytial virus (RSV); pneumococcal; hepatitis B; shingles; and tetanus, diphtheria, and pertussis (Tdap)], perceived risk of transferring residents to the hospital for these illnesses, and temporary suspension of admissions due to outbreaks. All measures were binary and sample averages were calculated separately for NHs and ALs. Facility characteristics associated with COVID-19-related admission suspensions were compared.

Results: NHs had a higher prevalence of vaccination programs for all 7 vaccine-preventable illnesses compared with ALs. The largest differences were observed for RSV, pneumococcal, hepatitis B, shingles, and Tdap. ALs reported higher perceived risk of transferring residents to the hospital for all illnesses, whereas NHs reported the highest perceived risk for respiratory illnesses. Temporary admission suspensions due to outbreaks were uncommon; when reported, they were primarily associated with COVID-19. Facilities with COVID-19-related suspensions were more likely to be smaller and not-for-profit/government owned. NHs with outbreaks were more often located in rural areas, and ALs with outbreaks were more often located in urban areas.

Conclusions and implications: Significant disparities exist in vaccination program implementation between NHs and ALs. Expanding vaccination programs in ALs may reduce hospitalization risk and strengthen outbreak prevention. Targeted policy efforts, improved education, and resource allocation are needed to ensure equitable access to comprehensive vaccination programs across long-term care settings.

目的:比较疗养院(NHs)和辅助生活社区(ALs)之间疫苗接种计划的流行程度,并检查这些计划与感知住院风险和因疫情而暂时暂停住院的关系。设计:对2023年俄亥俄州长期护理设施两年一次调查的设施级调查数据进行描述性分析,该调查的回复率为90%。环境和参与者:调查了俄亥俄州所有有执照的NHs和ALs,并回答了与疫苗接种计划相关的问题(N = 736; N = 623)。方法:分析三项措施:7种疫苗可预防疾病(流感、COVID-19、呼吸道合胞病毒(RSV)、肺炎球菌、乙型肝炎、带状疱疹、破伤风、白喉和百日咳[Tdap])的疫苗接种计划,因这些疾病将居民转移到医院的感知风险,以及因疫情而暂时停止住院。所有测量都是二元的,NHs和ALs的样本平均值分别计算。比较了与covid -19相关的停学相关的设施特征。结果:与ALs相比,NHs对所有7种疫苗可预防疾病的疫苗接种计划的患病率更高。RSV、肺炎球菌、乙型肝炎、带状疱疹和Tdap的差异最大。ALs报告了将居民转移到医院治疗所有疾病的更高感知风险,而NHs报告了呼吸系统疾病的最高感知风险。因疫情而暂停入院的情况并不常见;报告时,它们主要与COVID-19有关。与covid -19相关的停课设施更有可能是规模较小、非营利/政府所有的。发生疫情的国民保健系统多位于农村地区,而发生疫情的ALs多位于城市地区。结论和意义:NHs和ALs在疫苗接种计划实施方面存在显著差异。扩大ALs的疫苗接种计划可以降低住院风险并加强疫情预防。需要有针对性的政策努力、改进的教育和资源分配,以确保在长期护理环境中公平获得全面的疫苗接种规划。
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引用次数: 0
The Association of Pain With Physical Performance Among Community-Dwelling Older Adults in the PRO-EVA Study. 在PRO-EVA研究中,社区居住的老年人疼痛与身体表现的关系。
IF 3.8 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-04 DOI: 10.1016/j.jamda.2025.106110
Aline Dos Santos Mendes, Sabrina Gabrielle Gomes Fernandes Mâcedo, Weslley Barbosa Sales, Paulo Eduardo E Silva Barbosa, Edgar Ramos Vieira, Álvaro Campos Cavalcanti Maciel

Objectives: To examine which pain-related characteristics are most strongly associated with impairments in physical performance among community-dwelling older adults.

Design: Cross-sectional study with no intervention.

Setting and participants: A total of 694 adults aged 60 years or older, of both sexes, registered in Primary Health Care Units in Parnamirim, Brazil.

Methods: Chronic pain (lasting more than 3 months) was self-reported. Physical performance was assessed using the Short Physical Performance Battery (SPPB). Bivariate analyses were conducted using Student's t-tests and χ2 tests. Multiple linear regression was applied to evaluate the association between pain-related variables and total SPPB scores, adjusting for covariates.

Results: Chronic pain prevalence was 56%. Pain exacerbation during walking was reported by 32%, and mean pain intensity was 5.7. The mean SPPB score was 9 (±2), and 31% of participants had low physical performance. Pain intensity and pain while walking were associated with worse physical performance; however, only pain intensity remained an independent predictor in adjusted models. Additional factors associated with lower performance included female sex, polypharmacy, lower engagement in walking activity, and lower Leganés Cognitive Test (LCT) scores.

Conclusions and implications: Chronic pain, especially its intensity, is independently associated with reduced physical performance in older adults. These findings reinforce the need for primary care services to prioritize the identification and management of chronic pain to help preserve mobility and functional capacity in aging populations.

目的:研究在社区居住的老年人中,哪些与疼痛相关的特征与身体机能障碍最密切相关。设计:无干预的横断面研究。环境和参与者:在巴西帕纳米rim的初级保健单位登记的60岁或以上的男女成年人共有694人。方法:慢性疼痛(持续3个月以上)自我报告。使用短物理性能电池(SPPB)评估物理性能。采用学生t检验和χ2检验进行双变量分析。采用多元线性回归评估疼痛相关变量与SPPB总分之间的相关性,并对协变量进行调整。结果:慢性疼痛患病率为56%。行走时疼痛加重的比例为32%,平均疼痛强度为5.7。SPPB平均得分为9(±2)分,31%的参与者体能表现较差。疼痛强度和走路时疼痛与较差的身体表现有关;然而,在调整后的模型中,只有疼痛强度仍然是一个独立的预测因子。与较低表现相关的其他因素包括女性、多种药物、较少的步行活动和较低的legansams认知测试(LCT)分数。结论和意义:慢性疼痛,尤其是其强度,与老年人身体活动能力下降独立相关。这些发现加强了初级保健服务优先识别和管理慢性疼痛的必要性,以帮助保持老年人的活动能力和功能能力。
{"title":"The Association of Pain With Physical Performance Among Community-Dwelling Older Adults in the PRO-EVA Study.","authors":"Aline Dos Santos Mendes, Sabrina Gabrielle Gomes Fernandes Mâcedo, Weslley Barbosa Sales, Paulo Eduardo E Silva Barbosa, Edgar Ramos Vieira, Álvaro Campos Cavalcanti Maciel","doi":"10.1016/j.jamda.2025.106110","DOIUrl":"10.1016/j.jamda.2025.106110","url":null,"abstract":"<p><strong>Objectives: </strong>To examine which pain-related characteristics are most strongly associated with impairments in physical performance among community-dwelling older adults.</p><p><strong>Design: </strong>Cross-sectional study with no intervention.</p><p><strong>Setting and participants: </strong>A total of 694 adults aged 60 years or older, of both sexes, registered in Primary Health Care Units in Parnamirim, Brazil.</p><p><strong>Methods: </strong>Chronic pain (lasting more than 3 months) was self-reported. Physical performance was assessed using the Short Physical Performance Battery (SPPB). Bivariate analyses were conducted using Student's t-tests and χ<sup>2</sup> tests. Multiple linear regression was applied to evaluate the association between pain-related variables and total SPPB scores, adjusting for covariates.</p><p><strong>Results: </strong>Chronic pain prevalence was 56%. Pain exacerbation during walking was reported by 32%, and mean pain intensity was 5.7. The mean SPPB score was 9 (±2), and 31% of participants had low physical performance. Pain intensity and pain while walking were associated with worse physical performance; however, only pain intensity remained an independent predictor in adjusted models. Additional factors associated with lower performance included female sex, polypharmacy, lower engagement in walking activity, and lower Leganés Cognitive Test (LCT) scores.</p><p><strong>Conclusions and implications: </strong>Chronic pain, especially its intensity, is independently associated with reduced physical performance in older adults. These findings reinforce the need for primary care services to prioritize the identification and management of chronic pain to help preserve mobility and functional capacity in aging populations.</p>","PeriodicalId":17180,"journal":{"name":"Journal of the American Medical Directors Association","volume":" ","pages":"106110"},"PeriodicalIF":3.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To Sit or Stand? Evaluating the End Position of the 5-Times Chair-Stand Test (5-CST) Among Older Adults. 坐着还是站着?老年人5次椅架试验(5-CST)结束位置评价
IF 3.8 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-04 DOI: 10.1016/j.jamda.2025.106079
Si Qi Lim, Yong-Hao Pua, Amber Wong, Suet Ching Jennifer Liaw, Wan Qi Yee, Xiaoting Huang, Lian Leng Low
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引用次数: 0
Social Participation and Digital Health Literacy Among Older Adults in the Community: The Mediating Roles of Self-Efficacy and Technophobia. 社区老年人的社会参与与数字健康素养:自我效能感和技术恐惧症的中介作用
IF 3.8 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-03 DOI: 10.1016/j.jamda.2026.106111
Haichao Wang, Li Yang, Danqing Hu, Xiaomin Tu, Yangyang Hu, Mengni Tang, Aimin Wang

Objectives: This study aimed to explore how self-efficacy and technophobia mediate the relationship between social participation and digital health literacy among older adults living in the community.

Design: We conducted a cross-sectional survey.

Setting and participants: We recruited 665 older adults in Qingdao, China, from September 2024 to February 2025.

Methods: Data were collected on sociodemographic characteristics, social participation, self-efficacy, technophobia, and digital health literacy. The SPSS PROCESS macro was used to investigate the mediating role of self-efficacy and technophobia between social participation and digital health literacy.

Results: There were positive correlations among social participation, self-efficacy, and digital health literacy (r = 0.429-0.646, P<.001), whereas technophobia was significantly and negatively correlated with these variables (r = -0.525 to -0.273, P<.001). In the mediation model, social participation was positively associated with digital health literacy (β = 0.284, P<.001). This association was accounted for by both the independent mediating roles of self-efficacy and technophobia, as well as their sequential roles as serial mediators.

Conclusions and implications: Social participation is associated with digital health literacy through the pathways of self-efficacy and technophobia. By fostering engagement opportunities, supportive environments, and positive role models, communities and families may help create conditions that are conducive to higher self-efficacy and lower technophobia among older adults, both of which are associated with higher levels of digital health literacy and a greater ability to benefit from opportunities in the digital age.

目的:本研究旨在探讨自我效能感和技术恐惧如何中介社区老年人社会参与与数字健康素养之间的关系。设计:我们进行了一个横断面调查。环境和参与者:从2024年9月到2025年2月,我们在中国青岛招募了665名老年人。方法:收集社会人口学特征、社会参与、自我效能、技术恐惧症和数字健康素养等方面的数据。使用SPSS PROCESS宏来调查自我效能感和技术恐惧在社会参与和数字健康素养之间的中介作用。结果:社会参与、自我效能感和数字健康素养之间存在显著正相关(r = 0.429-0.646, p)。结论与意义:社会参与通过自我效能感和技术恐惧通路与数字健康素养相关。通过促进参与机会、支持性环境和积极的榜样,社区和家庭可以帮助创造有利于老年人提高自我效能和降低技术恐惧症的条件,这两者都与更高水平的数字健康素养和更大的能力有关,从数字时代的机会中受益。
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引用次数: 0
Independent and Combined Associations of Handgrip and Knee Extension Strength With Cognitive Function in Community-Dwelling Older Adults. 在社区居住的老年人中,手握和膝关节伸展力量与认知功能的独立和联合关联。
IF 3.8 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-03 DOI: 10.1016/j.jamda.2026.106112
Yosuke Yamada, Aiko Inoue, Hirotaka Nakashima, Kazuhisa Watanabe, Chisato Fujisawa, Hitoshi Komiya, Tomihiko Tajima, Hiroyuki Umegaki

Objectives: To examine the independent and combined associations of handgrip strength (HGS) and knee extension strength (KES) with global cognition in community-dwelling older adults.

Design: Cross-sectional analysis of baseline data from a prospective cohort.

Setting and participants: A total of 279 community-dwelling adults aged 65 years or older living independently (mean age 76.8 ± 5.9; 26.5% men).

Methods: Low strength was defined as the sex-specific lowest quartile (Q1). Multiple linear regression estimated differences in Mini-Mental State Examination (MMSE) scores adjusting for age, sex, education, and depressive symptoms (GDS-15). We examined (1) HGS and KES together, (2) 4 exclusive groups (low KES only, low HGS only, both low, neither), and (3) sensitivity analyses including skeletal muscle index and sex-stratified analyses using weight-normalized KES.

Results: Low KES related to lower MMSE (Model 1 B, -0.882; 95% CI, -1.542 to -0.223, P = .009; Model 2 B, -0.892; 95% CI, -1.564 to -0.219; P = .010). Low HGS was not significant (P ≥ .27). When both were included, low KES remained significant (B, -0.814; 95% CI, -1.509 to -0.119; P = .022) but low HGS did not. In 4-group analysis, both low KES and HGS vs neither showed lower MMSE (B, -1.054; 95% CI, -1.984 to -0.112; P = .027). Associations for KES persisted after adjusting for skeletal muscle index (B, -0.842; 95% CI, -1.522 to -0.161; P = .016). In sex-stratified models, weight-normalized KES was associated with MMSE in men (B, 6.598; 95% CI, 2.258 to 10.939; P = .004) but not in women.

Conclusions and implications: Lower KES shows a consistent and independent association with global cognition; combined weakness in upper and lower limbs signals greater cognitive deficit. Adding KES to community screening may improve early detection of cognitive vulnerability.

目的:探讨社区老年人握力(HGS)和膝关节伸展力(KES)与全球认知的独立和联合关系。设计:对前瞻性队列基线数据进行横断面分析。环境和参与者:共有279名65岁及以上独立生活的社区居民(平均年龄76.8±5.9岁;男性26.5%)。方法:低强度被定义为性别特异性最低四分位数(Q1)。多元线性回归估计了年龄、性别、教育程度和抑郁症状(GDS-15)调整后的最小精神状态检查(MMSE)得分的差异。我们检查了(1)HGS和KES,(2) 4个排他组(仅低KES,仅低HGS,均低,均不低),以及(3)敏感性分析,包括骨骼肌指数和使用权重归一化KES的性别分层分析。结果:低KES与低MMSE相关(模型1b, -0.882; 95% CI, -1.542 ~ -0.223, P = 0.009;模型2b, -0.892; 95% CI, -1.564 ~ -0.219; P = 0.010)。低HGS无显著性差异(P≥0.27)。当两者均纳入时,低KES仍然显著(B, -0.814; 95% CI, -1.509至-0.119;P = 0.022),但低HGS则不显著。在4组分析中,低KES和低HGS与两者均较低的MMSE (B, -1.054; 95% CI, -1.984 ~ -0.112; P = 0.027)。调整骨骼肌指数后,KES的相关性仍然存在(B, -0.842; 95% CI, -1.522至-0.161;P = 0.016)。在性别分层模型中,体重归一化KES与男性MMSE相关(B, 6.598; 95% CI, 2.258 ~ 10.939; P = 0.004),但与女性无关。结论和意义:低KES与整体认知具有一致且独立的关联;上肢和下肢同时无力表明更严重的认知缺陷。将KES加入到社区筛查中可以改善认知脆弱性的早期发现。
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引用次数: 0
Cognitive and Functional Trajectories Among Older Widowed Male Veterans: Findings From the Health and Retirement Study. 老年丧偶男性退伍军人的认知和功能轨迹:来自健康和退休研究的发现。
IF 3.8 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-02 DOI: 10.1016/j.jamda.2025.106078
Nicole D Evangelista, Jordan N Kohn, Molly A Patapoff, Jeonghyun Shin, Dylan J Jester

Objectives: Loss of a spouse increases risk for cognitive and functional decline in older age. However, literature examining bereavement effects on cognition and daily functioning in veterans is limited. This study therefore examined differences in cognitive and functional trajectories after spousal loss in older male veterans.

Design: Retrospective cohort study.

Setting and participants: Participants included 3339 male, community-dwelling veterans in the Health and Retirement Study aged >51 years who were married/partnered at enrollment and remained married (n = 2849) or became widowed (n = 490).

Methods: Participants completed biannual cognitive testing (Telephone Interview of Cognitive Status) and basic activities of daily living (ADL) and instrumental activities of daily living (IADL) questionnaires, and reported medical comorbidities and marital status. A generalized additive mixed-effects model compared annual rates of cognitive decline between married and widowed participants. Negative binomial regression evaluated associations between widowhood, ADLs, and IADLs. Poisson regression tested associations between widowhood and medical comorbidities. All models adjusted for age, race, ethnicity, years of education, depression, recent hospitalization, medical comorbidities, body mass index, years worked, income, and mortality.

Results: Results indicated greater cognitive decline after spousal loss between ages 64 to 76 years and after aged 84 years. Widowhood was associated with greater IADL difficulty [incidence rate ratio (IRR), 1.20; 95% CI, 1.01-1.43] and requiring IADL assistance (IRR, 1.38; 95% CI, 1.14-1.68). No associations were found between widowhood and basic ADL difficulty (IRR, 1.14; 95% CI, 0.97-1.34), requiring ADL assistance (IRR, 1.04; 95% CI, 0.77-1.41), or medical comorbidities (IRR, 0.99; 95% CI, 0.94-1.04). Sensitivity analyses including only widowers revealed greater post-loss ADL difficulty (IRR, 1.30; 95% CI, 1.04-1.63), ADL assistance (IRR, 1.76; 95% CI, 1.14-2.73), and medical comorbidities (IRR, 1.12; 95% CI, 1.05-1.20).

Conclusions and implications: Compared with married veterans, widowers had greater rates of cognitive decline, greater difficulty completing IADLs, and increased medical comorbidities. These findings may inform access to mental health services addressing bereavement and other clinical outcomes after widowhood.

目的:丧偶增加老年认知和功能衰退的风险。然而,研究丧亲之痛对退伍军人认知和日常功能影响的文献有限。因此,本研究考察了老年男性退伍军人失去配偶后认知和功能轨迹的差异。设计:回顾性队列研究。环境和参与者:参与者包括3339名男性,社区居住的退伍军人,在健康和退休研究中年龄在bb0 - 51岁,在登记时已婚/有伴侣,并保持已婚(n = 2849)或丧偶(n = 490)。方法:参与者完成一年两次的认知测试(认知状态电话访谈)和基本日常生活活动(ADL)和工具性日常生活活动(IADL)问卷,并报告医疗合并症和婚姻状况。一个广义的加性混合效应模型比较了已婚和丧偶参与者之间认知能力下降的年速率。负二项回归评估丧偶、ADLs和ADLs之间的关系。泊松回归检验了丧偶与医疗合并症之间的关系。所有模型都对年龄、种族、民族、受教育年限、抑郁症、最近住院、医疗合并症、体重指数、工作年限、收入和死亡率进行了调整。结果:结果表明,在64 - 76岁和84岁之后,失去配偶后认知能力下降更大。丧偶与较高的IADL困难(发病率比[IRR], 1.20; 95% CI, 1.01-1.43)和需要IADL辅助(IRR, 1.38; 95% CI, 1.14-1.68)相关。寡居与基本ADL困难(IRR, 1.14; 95% CI, 0.97-1.34)、需要ADL辅助(IRR, 1.04; 95% CI, 0.77-1.41)或医学合并症(IRR, 0.99; 95% CI, 0.94-1.04)之间没有关联。仅包括丧偶者的敏感性分析显示,丧偶后的ADL困难(IRR, 1.30; 95% CI, 1.04-1.63)、ADL辅助(IRR, 1.76; 95% CI, 1.14-2.73)和医疗合共病(IRR, 1.12; 95% CI, 1.05-1.20)更大。结论和意义:与已婚退伍军人相比,丧偶军人的认知能力下降率更高,完成iadl的难度更大,医疗合并症也更多。这些发现可能有助于获得精神卫生服务,解决丧亲之痛和丧偶后的其他临床结果。
{"title":"Cognitive and Functional Trajectories Among Older Widowed Male Veterans: Findings From the Health and Retirement Study.","authors":"Nicole D Evangelista, Jordan N Kohn, Molly A Patapoff, Jeonghyun Shin, Dylan J Jester","doi":"10.1016/j.jamda.2025.106078","DOIUrl":"10.1016/j.jamda.2025.106078","url":null,"abstract":"<p><strong>Objectives: </strong>Loss of a spouse increases risk for cognitive and functional decline in older age. However, literature examining bereavement effects on cognition and daily functioning in veterans is limited. This study therefore examined differences in cognitive and functional trajectories after spousal loss in older male veterans.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Setting and participants: </strong>Participants included 3339 male, community-dwelling veterans in the Health and Retirement Study aged >51 years who were married/partnered at enrollment and remained married (n = 2849) or became widowed (n = 490).</p><p><strong>Methods: </strong>Participants completed biannual cognitive testing (Telephone Interview of Cognitive Status) and basic activities of daily living (ADL) and instrumental activities of daily living (IADL) questionnaires, and reported medical comorbidities and marital status. A generalized additive mixed-effects model compared annual rates of cognitive decline between married and widowed participants. Negative binomial regression evaluated associations between widowhood, ADLs, and IADLs. Poisson regression tested associations between widowhood and medical comorbidities. All models adjusted for age, race, ethnicity, years of education, depression, recent hospitalization, medical comorbidities, body mass index, years worked, income, and mortality.</p><p><strong>Results: </strong>Results indicated greater cognitive decline after spousal loss between ages 64 to 76 years and after aged 84 years. Widowhood was associated with greater IADL difficulty [incidence rate ratio (IRR), 1.20; 95% CI, 1.01-1.43] and requiring IADL assistance (IRR, 1.38; 95% CI, 1.14-1.68). No associations were found between widowhood and basic ADL difficulty (IRR, 1.14; 95% CI, 0.97-1.34), requiring ADL assistance (IRR, 1.04; 95% CI, 0.77-1.41), or medical comorbidities (IRR, 0.99; 95% CI, 0.94-1.04). Sensitivity analyses including only widowers revealed greater post-loss ADL difficulty (IRR, 1.30; 95% CI, 1.04-1.63), ADL assistance (IRR, 1.76; 95% CI, 1.14-2.73), and medical comorbidities (IRR, 1.12; 95% CI, 1.05-1.20).</p><p><strong>Conclusions and implications: </strong>Compared with married veterans, widowers had greater rates of cognitive decline, greater difficulty completing IADLs, and increased medical comorbidities. These findings may inform access to mental health services addressing bereavement and other clinical outcomes after widowhood.</p>","PeriodicalId":17180,"journal":{"name":"Journal of the American Medical Directors Association","volume":" ","pages":"106078"},"PeriodicalIF":3.8,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and Factors Associated With Hospitalizations for Urinary Tract Infections Among Older People Residing in Long-Term Care Facilities. 长期护理机构中老年人尿路感染住院的发病率和相关因素
IF 3.8 2区 医学 Q2 GERIATRICS & GERONTOLOGY Pub Date : 2026-02-02 DOI: 10.1016/j.jamda.2025.106073
Yohanes A Wondimkun, Maria C Inacio, Noleen Bennett, Leon J Worth, Karin Thursky, Rodney James, Malcolm Clark, Janet K Sluggett

Objectives: This study examined the incidence of hospitalizations for urinary tract infections (UTIs) and associated factors among residents of long-term care facilities (LTCFs) during the first 12 months of their LTCF stay.

Design: Population-based retrospective cohort study.

Setting and participants: This study included people aged ≥65 years who first entered an LTCF between 2015 and 2018 using data from the Registry of Senior Australians National Historical Cohort.

Methods: The cumulative incidence of hospitalizations of UTI in the 12 months following LTCF entry was evaluated. Individual, facility, medicine, and service utilization-related factors associated with hospitalizations for UTIs were investigated. A Fine-Gray model was used to estimate subdistribution hazard ratios (sHRs) and 95% CIs.

Results: Of the 180,858 people included from 2464 LTCFs, 59.7% (n = 107,914) were female, with a median age of 85 years. The cumulative incidence of hospitalizations for UTIs in the 12 months after LTCF entry was 3.7% (95% CI 3.7-3.8). Factors associated with a higher rate of hospitalizations for UTIs included long-term urinary catheter use (sHR 3.39, 95% CI 3.16-3.65), history of hospitalizations with UTI (sHR 2.33, 95% CI 2.21-2.46), preferred language other than English (sHR 1.38, 95% CI 1.28-1.48), diabetes (sHR 1.29, 95% CI 1.22-1.37), high (sHR 1.30, 95% CI 1.19-1.41) or medium (sHR 1.21, 95% CI 1.11-1.32) need for assistance with activities of daily living, cerebrovascular disease (sHR 1.14, 95% CI 1.08-1.20), and urinary incontinence (sHR 1.08, 95% CI 1.01-1.15).

Conclusions and implications: A considerable burden of UTI-associated hospitalizations was observed in Australian LTCFs, which can be minimized through implementing effective UTI prevention, detection, and management strategies.

目的:本研究调查了长期护理机构(LTCF)住院的前12个月内尿路感染(uti)住院的发生率及其相关因素。设计:基于人群的回顾性队列研究。环境和参与者:本研究包括年龄≥65岁的人,他们在2015年至2018年期间首次进入LTCF,使用的数据来自澳大利亚老年人国家历史队列登记处。方法:评估LTCF入组后12个月内尿路感染住院累计发生率。调查了与尿路感染住院相关的个人、设施、药物和服务利用相关因素。采用Fine-Gray模型估计亚分布风险比(sHRs)和95% ci。结果:在2464例ltcf纳入的180858例患者中,59.7% (n = 107914)为女性,中位年龄为85岁。LTCF入组后12个月内尿路感染住院的累计发生率为3.7% (95% CI 3.7-3.8)。与尿路感染住院率较高相关的因素包括:长期使用导尿管(sHR 3.39, 95% CI 3.16-3.65)、尿路感染住院史(sHR 2.33, 95% CI 2.21-2.46)、首选非英语语言(sHR 1.38, 95% CI 1.28-1.48)、糖尿病(sHR 1.29, 95% CI 1.22-1.37)、日常生活活动需要帮助程度高(sHR 1.30, 95% CI 1.19-1.41)或中等(sHR 1.21, 95% CI 1.11-1.32)、脑血管疾病(sHR 1.14, 95% CI 1.08-1.20)。尿失禁(sHR 1.08, 95% CI 1.01-1.15)。结论和意义:在澳大利亚ltcf中观察到与尿路感染相关的住院负担相当大,可以通过实施有效的尿路感染预防、检测和管理策略将其降至最低。
{"title":"Incidence and Factors Associated With Hospitalizations for Urinary Tract Infections Among Older People Residing in Long-Term Care Facilities.","authors":"Yohanes A Wondimkun, Maria C Inacio, Noleen Bennett, Leon J Worth, Karin Thursky, Rodney James, Malcolm Clark, Janet K Sluggett","doi":"10.1016/j.jamda.2025.106073","DOIUrl":"10.1016/j.jamda.2025.106073","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the incidence of hospitalizations for urinary tract infections (UTIs) and associated factors among residents of long-term care facilities (LTCFs) during the first 12 months of their LTCF stay.</p><p><strong>Design: </strong>Population-based retrospective cohort study.</p><p><strong>Setting and participants: </strong>This study included people aged ≥65 years who first entered an LTCF between 2015 and 2018 using data from the Registry of Senior Australians National Historical Cohort.</p><p><strong>Methods: </strong>The cumulative incidence of hospitalizations of UTI in the 12 months following LTCF entry was evaluated. Individual, facility, medicine, and service utilization-related factors associated with hospitalizations for UTIs were investigated. A Fine-Gray model was used to estimate subdistribution hazard ratios (sHRs) and 95% CIs.</p><p><strong>Results: </strong>Of the 180,858 people included from 2464 LTCFs, 59.7% (n = 107,914) were female, with a median age of 85 years. The cumulative incidence of hospitalizations for UTIs in the 12 months after LTCF entry was 3.7% (95% CI 3.7-3.8). Factors associated with a higher rate of hospitalizations for UTIs included long-term urinary catheter use (sHR 3.39, 95% CI 3.16-3.65), history of hospitalizations with UTI (sHR 2.33, 95% CI 2.21-2.46), preferred language other than English (sHR 1.38, 95% CI 1.28-1.48), diabetes (sHR 1.29, 95% CI 1.22-1.37), high (sHR 1.30, 95% CI 1.19-1.41) or medium (sHR 1.21, 95% CI 1.11-1.32) need for assistance with activities of daily living, cerebrovascular disease (sHR 1.14, 95% CI 1.08-1.20), and urinary incontinence (sHR 1.08, 95% CI 1.01-1.15).</p><p><strong>Conclusions and implications: </strong>A considerable burden of UTI-associated hospitalizations was observed in Australian LTCFs, which can be minimized through implementing effective UTI prevention, detection, and management strategies.</p>","PeriodicalId":17180,"journal":{"name":"Journal of the American Medical Directors Association","volume":" ","pages":"106073"},"PeriodicalIF":3.8,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Journal of the American Medical Directors Association
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