Journal of the Indian Chemical Society最新文献

{"title":"Synthesis and characterization of Zn-based quantum dots and investigation of their potential in antibacterial infections","authors":"Mohammed Asiri ,&nbsp;Farag M.A. Altalbawy ,&nbsp;Jayanti Makasana ,&nbsp;Dukhbhanjan Singh ,&nbsp;Mamata Chahar ,&nbsp;Nashwan Salah Aldeen Darwish ,&nbsp;M Ravi Kumar ,&nbsp;Pushpa Negi Bhakuni ,&nbsp;Aziz Kubaev ,&nbsp;Morug Salih Mahdi ,&nbsp;Usama Kadem Radi ,&nbsp;Nasr Saadoun Abd ,&nbsp;Munthar Kadhim Abosaoda","doi":"10.1016/j.jics.2024.101530","DOIUrl":"10.1016/j.jics.2024.101530","url":null,"abstract":"<div><div>The burgeoning field of nanomaterials has spotlighted zinc-based quantum dots (Zn-QDs) as promising antibacterial agents. This review comprehensively analyzes their synthesis methods, characterization techniques, antibacterial mechanisms, and potential applications. Synthesis approaches, such as chemical precipitation, sol-gel processes, and hydrothermal techniques, enable the production of Zn-QDs with controlled sizes (typically 3–6 nm), which exhibit potent antibacterial properties. Characterization tools, including transmission electron microscopy (TEM), scanning electron microscopy (SEM), and UV–Vis spectroscopy, confirm their nanoscale dimensions and distinct optical properties. Among Zn-QDs, ZnO-QDs demonstrate remarkable antibacterial activity by generating reactive oxygen species (ROS) and releasing Zn²⁺ ions, achieving bacterial growth inhibition rates of 85–99 % against pathogens like <em>E. coli</em> and <em>S. aureus</em>. Similarly, ZnS-QDs exhibit ROS-mediated efficacy, with up to 78.25 % inhibition against <em>E. coli</em> when incorporated into polymer films. Advances in doping strategies, such as Co-doped ZnO-QDs and Mg-doped ZnS-QDs, further enhance their antibacterial potency, achieving bacterial growth reductions of 88 % and inhibition zones of up to 24 mm, respectively. This review also addresses critical safety and biocompatibility considerations, emphasizing the need for rigorous evaluations before clinical deployment. Finally, it highlights future research directions, including functionalization with synergistic antibacterial agents and the integration of Zn-QDs into advanced therapeutic systems to overcome current challenges and unlock their full potential.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 1","pages":"Article 101530"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing electrochemical performance of vanadium-doped ZnO nanoparticles based supercapacitor","authors":"Manisha Yadav ,&nbsp;Jitendra Kumar Yadav ,&nbsp;Sanju Choudhari ,&nbsp;Pradeep Kumar ,&nbsp;Pura Ram","doi":"10.1016/j.jics.2024.101529","DOIUrl":"10.1016/j.jics.2024.101529","url":null,"abstract":"<div><div>Metal-ion-doped transition metal oxides (TMOs) are suggested as innovative electrode materials with excellent cycling efficiency for asymmetric supercapacitors (ASCs). Here, we use a hydrothermal technique to synthesize vanadium (V) doped zinc oxide nanoparticles (NPs) as the electrode material for ASCs. The synthesized material pristine zinc oxide (ZO), 2 atomic% (at%) V-doped zinc oxide (2VZO), and 4 at% V-doped zinc oxide (4VZO) have been validated using various physical characterization techniques including XRD, FE-SEM, TGA, XPS, Raman, and FTIR techniques. The detailed electrochemical characterizations were performed, including CV, GCD, and EIS. The CV is investigated at the various scan rates, and GCD measurements are carried out to understand their charge-discharge characteristics at various current densities. The fabricated supercapacitor exhibits specific capacitance (<span><math><mrow><msub><mi>C</mi><mrow><mi>s</mi><mi>p</mi></mrow></msub></mrow></math></span>) for ZO, 2VZO, and 4VZO are 71.53, 103.90, and 126.78 F g⁻¹ at 10 mV s⁻¹ scan rate, respectively. The 4VZO material-based device exhibits the maximum energy and power density ∼16 Wh kg⁻¹ and 4 kW kg⁻¹, respectively. The electrochemical impedance spectroscopy measurements are also carried out to understand the interface impedances and their impact on electrochemical performance.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 1","pages":"Article 101529"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inspection the impact of mixing and external resistance on the Microbial Desalination Cell for electricity generation and desalination efficiency by using Macroalgae as a bio-cathode","authors":"Hussein H. Abd-almohi ,&nbsp;Ziad T. Alismaeel ,&nbsp;Mohanad J. M-Ridha","doi":"10.1016/j.jics.2024.101543","DOIUrl":"10.1016/j.jics.2024.101543","url":null,"abstract":"<div><div>Microbial desalination cell (MDC) is a promising and effective desalination method for water treatment and electric power production. Three different external resistances were studied in this research (50, 100 and 150 kΩ) with two concentrations of NaCl (15 and 25 g/L) for each resistor, and the maximum voltages generated were 71, 167 and 202 mV, respectively. The maximum NaCl removal rate from the middle chamber increased from 0.164 g/L/h to 0.226 g/L/h when the external resistance was 150 kΩ for 15 and 25 g/L, respectively. The presence of mixing in the desalting chamber resulted in a maximum voltage of 256 mV with 150 kΩ, a desalting efficiency of 42 % and a removal efficiency of 25 % after 48 h of operation for the bio-cathode. For the chemical catholyte, the maximum voltages obtained were 238, 385 and 442 mV for 50, 100 and 150 kΩ, respectively; the maximum NaCl removal efficiency was 31 % and 33 % for 15 and 25 g/L with 150 kΩ, respectively. This study investigated the possibility of finding a description and equation for COD removal from wastewater in the anode chamber using the Design Experimental® program. The maximum COD removal efficiency obtained was 51 % after 24 h of operation. These findings underscore the potential of MDCs as efficient, sustainable technologies for water treatment and energy production.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 1","pages":"Article 101543"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pro Transferosome Loaded Gefitinib Novel Tablet for pulmonary drug delivery: Optimization and characterization","authors":"Krishna Swaroop ,&nbsp;Basavaraju S.B ,&nbsp;Samathoti Prasanthi ,&nbsp;Prakash Goudanavar ,&nbsp;Nimbagal Raghavendra Naveen ,&nbsp;Nagaraja Sreeharsha ,&nbsp;Girish Meravanige ,&nbsp;Afzal Haq Asif","doi":"10.1016/j.jics.2024.101520","DOIUrl":"10.1016/j.jics.2024.101520","url":null,"abstract":"<div><div>The aim of this study is to optimize and characterize gefitinib-loaded Protransferosome tablets for pulmonary drug delivery. Gefitinib is a chemotherapy drug used primarily for the treatment of certain types of non-small cell lung cancer (NSCLC). It is a member of the tyrosine kinase inhibitor (TKI) class of medications. Gefitinib works by targeting and inhibiting the epidermal growth factor receptor (EGFR) tyrosine kinase, which has impact on the growth and proliferation of malignant cells. The extensive surface region of the respiratory system provides an ideal site for localized anti-cancer drug delivery within the lungs. Gefitinib loaded Protransferosomes (PT) were prepared by using rotary film evaporation method. The Box-Behnken statistical design was utilized to optimize the formulation and identify the variable parameters that impact the vesicle size, zeta potential and entrapment efficiency. Finally, the formulated Gefitinib Protransferosomes was undergo direct compression method. which was evaluated for weight variation test, Thickness test, Hardness test, disintegration test, Friability test, and Dissolution test. The GFT-loaded LMH powders, particularly O GFT PTS (lipid phase-to-carrier ratio of 1:25 w/w), showed remarkable flowability, as indicated by a favorable angle of repose (AOR) and a excellent compressibility index due to their small and homogeneous particle size. The prepared GFT PT had high encapsulation efficiencies (EE%) ranging from 52.2 ± 0.66 % to 75.6 ± 1.12 %, with Vesicle sizes varying from 3.153 ± 0.153 μm to 5.39 ± 0.684 μm, and zeta potentials ranging from −26.6 mV to −35.9 mV. Scanning electron microscopy discovered that the protransferosomes were circular in shape. In-vitro release studies conducted over 1 h for the optimal formulation shown a better cumulative drug release (CDR) of 94.24 % for Gefitinib. Stability results showed no significant changes in weight variation, hardness, friability, thickness, or dissolution tests. The development and optimization of Protransferosome-loaded tablets show promising results for pulmonary drug delivery. The optimized formulation demonstrates improved drug delivery performance, with the potential for enhanced therapeutic efficacy in respiratory conditions. Further studies and clinical evaluations may be required to validate these findings in practical applications.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 1","pages":"Article 101520"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steam-treated SAPO-18 with well-regulated acidity and excellent DTO performance","authors":"You Gyong Ho ,&nbsp;Song Chol Jong ,&nbsp;Un Yong Paek ,&nbsp;Un Chol Han ,&nbsp;Hyon-Tae Pak ,&nbsp;Ri Myong Kim","doi":"10.1016/j.jics.2024.101505","DOIUrl":"10.1016/j.jics.2024.101505","url":null,"abstract":"<div><div>The hydrothermally synthesized SAPO-18 catalyst was steam treated to investigate the catalytic performance in dimethyl ether to olefins (DTO) reaction. After steam treatment, micropores and mesopores were created on the SAPO-18 catalyst. To evaluate the catalytic activity of steamed SAPO-18, the DTO reaction was carried out at 673 K with weight hourly space velocity (WHSV) of 3.546 h⁻¹, and the steamed SAPO-18 (S-773) at 773 K exhibited excellent DTO conversion performance (single-run lifetime 5.5 h, light olefin selectivity 95.9 %) with BET surface area of 737 m² g⁻¹, mesopore volume of 125 mm³ g⁻¹, total amount of acid sites of 533 μmol g⁻¹, and Brønsted/Lewis ratio of 0.97. The improvement of DTO stability can be attributed to the increased mesoporosity and significantly reduced total amount of acid sites (well-regulated Brønsted/Lewis ratio) after steam treatment of SAPO-18 catalyst.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 1","pages":"Article 101505"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An efficient and sustainable multicomponent synthesis of structurally diverse tetrahydrochromeno[2,3-c]pyrazol-5(1H)-one using indium triflate as a reusable catalyst","authors":"Asha Verma ,&nbsp;Sandeep Kumar ,&nbsp;Vineeta Khatri ,&nbsp;Gargi Pathak ,&nbsp;Suresh Kumar Verma ,&nbsp;Dinesh Kumar Arya","doi":"10.1016/j.jics.2024.101561","DOIUrl":"10.1016/j.jics.2024.101561","url":null,"abstract":"<div><div>The effective and environmentally friendly synthetic approach has been presented for the synthesis of structurally diverse tetrahydrochromeno[2,3-c]pyrazol-5(1H)-one using indium triflate catalyzed the four-component reaction of aromatic aldehyde, 1,3-diketone, Phenylhydrazine and ethyl acetoacetate in solvent ethanol. The synthetic methodology has specific features such as atom and step economy, operational simplicity and excellent catalytic activity with sustainability, recyclability and reusability, resulting in structurally varied hybrid molecules with a unique combination of preferred substructures. The synthetic method of preparation of structurally diverse drug-like molecules has exceptional synthetic efficiency and molecular complexity in a shorter reaction time (15–20 min) and high product yield (85–95 %) at moderate temperatures, which contribute significantly to drug discovery research in medicinal and pharmaceutical chemistry.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 1","pages":"Article 101561"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surfactant additive enhanced stability and thermal conductivity of graphene (Gr) and ALN (AlN) nanolubricants","authors":"Yasmin Wadzer,&nbsp;Ye Zar Ni Htwe,&nbsp;Hussin Mamat","doi":"10.1016/j.jics.2024.101553","DOIUrl":"10.1016/j.jics.2024.101553","url":null,"abstract":"<div><div>The stability of the nanoparticles is a vital concern in nanolubricants research, where poor dispersion stability has a negative impact on their heat transmission and tribological performance. Adding surfactants is a useful and effective way to change the surface properties of nanoparticles and lower the surface tension of base fluids. This makes nanoparticles more stable and easier to disperse in base fluids. Hence, this paper aims to study the compability of surfactant in terms of stability and thermal conductivity performance played by Graphene (Gr) and Aluminium Nitride (AlN) nanoparticles in the composition of 4GS Suniso compressor oil (CO) and Petronas 15W-40 engine oil (EO) nanolubricants. Additionally, the performance of the nanolubricants and the compatibility of the nanoparticles with surfactant in various base fluids were examined in this study providing insights into their suitability for enhancing the thermophysical properties of different base fluids. Furthermore, the majority of research have examined the same kind of nanoparticles; however, in this study, Gr and AlN, which are carbon- and ceramic-based nanoparticles, respectively, belong to two distinct classes of nanoparticles. Cetyltrimethylammonium bromide (CTAB), Sodium dodecylbenzene sulfonate (SDBS), and Sorbitan Monooleate (SPAN-80) are the surfactants employed in this study. Each of these surfactants has a different type; CTAB is cationic, SDBS is anionic, and SPAN-80 is a non-ionic surfactant. Hence, this study investigates the effect of surfactant type (cationic, anionic, and non-ionic) on the thermal conductivity performance of Gr and AlN-based nanolubricants in both compressor oil and engine oil, highlighting the role of surfactant-nanoparticle interactions in improving nanolubricant performance. Visual observation, thermal conductivity measurement, pH value measurement, Zeta Potential analyzer and viscosity measurement are used for the identification of compatibility surfactant for Gr and AlN in both base oils. The study revealed that SPAN-80 and CTAB are the most suitable for AlN and Gr, respectively, in both of CO and EO.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 1","pages":"Article 101553"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-extractive spectrophotometric estimation of indomethacin in pharmaceuticals and biological fluids via ion-pair complexes","authors":"Basima A.A. Saleem,&nbsp;Salim A. Mohammed,&nbsp;Amer Th. Al-Taee","doi":"10.1016/j.jics.2024.101532","DOIUrl":"10.1016/j.jics.2024.101532","url":null,"abstract":"<div><div>Two simple, rapid and inexpensive spectrophotometric methods were proposed for the determination of indomethacin in its pure form, pharmaceutical formulations and in the biological fluids. The two suggested approaches were based on the formation of a wine-red ion-pair complex between indomethacin and chrome azurol S in presence of cetylpyridinium chloride at pH4.8 (in method A) and a pinkish-red complex with methyl red in presence of cetyltrimethylammonium bromide at pH 4.3 (in method B). The two ion-pair complexes formed exhibit two maximum absorption peaks at the wavelengths of 513 and 527 nm in methods A and B, respectively. For both methods, optimal spectrophotometric conditions were established. The calibration graph of the two methods is linear and Beer's law was valid within the concentration ranges of 0.4–28 and 0.4–24 μg/mL with molar absorptivity values 2.6369 × 10⁴ and 3.0198 × 10⁴ L/mol.cm in method A and B, correspondingly. The precision (RSD%) value is better than ≤1.57 % for both methods depending on the concentration level. Both recommended methods A and B have low detection limit (LOD) values of 0.0281 and 0.0327, respectively. Results of the two suggested methods compare favorably with the published method and offer the virtues of stability and sensitivity. The two suggested methods have been employed successfully to estimate indomethacin in its pharmaceutical forms (capsules, suppositories and spray) and in the spiked human urine and serum samples with mean recoveries of 95.41–101.64 %, and no intrusions were noticed from the shared excipients additives present in the commercial pharmaceutical forms.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 1","pages":"Article 101532"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A path to the formation of superacids HPtnF5n+1(n=1–3) and their ability to form supersalts by using the ab initio technique","authors":"Vijay Singh ,&nbsp;D.V. Shukla ,&nbsp;Apoorva Dwivedi ,&nbsp;D.D. Dubey ,&nbsp;S.N. Tiwari ,&nbsp;S.A.H. Vuai ,&nbsp;Anoop Kumar Pandey","doi":"10.1016/j.jics.2024.101527","DOIUrl":"10.1016/j.jics.2024.101527","url":null,"abstract":"<div><div>In this article, our primary focus is to determine all possible ways of formation of superacids HPt_nF_5n+1 by using thermodynamic parameters. We have employed a combination of the DFT/B3LYP method and SDD basis set for Pt, 6-31+G(d, p) for F, H, and Li atoms for optimization and other calculations. The superacidic characteristics of HPt_nF_5n+1 are calculated using the deprotonation energy. The acidity of HPt_nF_5n+1 is closely correlated to the vertical detachment energy of the associated superhalogen anions. The chemical reactivity is determined using the frontier molecular orbitals HOMO and LUMO. Superacids' salt formation ability is calculated by the interaction of Pt_nF_5n+1 anions with alkali metal Li. The NBO charges on Li and Pt_nF_5n+1 define the type of interaction that occurs during LiPt_nF_5n+1 salt formation. Several nonlinear optical properties of LiPt_nF_5n+1, such as dipole moment, mean polarizability, anisotropic polarizability, and hyperpolarizability, are determined to analyze their NLO behavior. We anticipate that our discovery will open up new avenues for researchers to identify novel NLO materials in the future.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 1","pages":"Article 101527"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality by design assisted a stability indicating RP-HPLC method for the estimation of hesperidin in transfersome and marketed product","authors":"Sakshi N. Sonawane ,&nbsp;Bhaskar K. Kurangi ,&nbsp;Omkar A. Shelar ,&nbsp;Abhilash A. Jalalpure ,&nbsp;Nikhil Gawas ,&nbsp;Rahul Koli","doi":"10.1016/j.jics.2024.101521","DOIUrl":"10.1016/j.jics.2024.101521","url":null,"abstract":"<div><div>The present study aimed to develop and validate a Quality by Design (QbD)-assisted simple stability-indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method for the estimation of hesperidin in transfersomes and marketed formulations. This QbD strategic approach is innovative as it allows for optimization with minimal trial and error, making the HPLC method more efficient while enhancing robustness, reliability, and regulatory compliance. Hesperidin is a naturally occurring polyphenolic flavonoid widely distributed in citrus species, including oranges and lemons. Due to its extensive and attractive therapeutic potential, an efficient, accurate, and specialized HPLC technique was developed and validated according to ICH guidelines. A central composite design was employed for the analysis, offering the advantage of using a reduced number of design points and experimental runs. Using a C18 column (4.6 mm × 250 mm, 5 μm) and acetonitrile (0.1 % orthophosphoric acid) (70:30) as the mobile phase, chromatographic separation was performed at a wavelength of 284 nm and a flow rate of 1 ml/min. Hesperidin peaked around 4.6 min using the innovative analytical method. The method was found to be linear over a concentration range of 0.5–16 μg/ml. The developed method was robust, precise, and accurate, with a 98 % recovery. The limit of detection (LOD) was 0.453 μg/ml, and the limit of quantification (LOQ) was 1.375 μg/ml, with a relative standard deviation (RSD) of less than 2 %. Moreover, forced degradation studies of hesperidin were conducted, and the relevance of the developed method was evaluated on transfersome nanoformulations and marketed formulations, demonstrating its versatility and broad applicability. The hesperidin peak was well separated in the presence of degradation products. It was found that the developed method was adequate, sensitive, and specific. This research provides a comprehensive and innovative approach to hesperidin estimation, which can significantly impact quality control and formulation development.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"102 1","pages":"Article 101521"},"PeriodicalIF":3.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}