Journal of the Indian Chemical Society最新文献_第9页

Carbon enriched MgO, NiO, and BaCO3 as novel nanocomposite for facilitated basic red 46 sequestration from contaminated wastewater 富碳MgO、NiO和BaCO3作为新型纳米复合材料促进污染废水中碱性红46的吸附

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society

Pub Date : 2026-01-01 DOI: 10.1016/j.jics.2026.102398

Ehab A. Abdelrahman , Mohamed R. Elamin , Reem K. Shah , Nada S. Al-Kadhi

Basic red 46 is a cationic azo dye that can cause serious risks to aquatic ecosystems and human health because it is persistent, colored, and potentially toxic even at low levels. In this work, MgO/NiO/BaCO₃/C nanocomposites, denoted NBM600 and NBM800, were synthesized by a facile Pechini sol–gel route at 600 as well as 800 °C, respectively, for the removal of basic red 46 from contaminated wastewater. XRD patterns confirmed multiphase crystalline MgO, NiO, and BaCO₃ with carbon and showed an increase in average crystallite size from about 65.22 nm for NBM600 to 75.88 nm for NBM800, reflecting enhanced crystallinity at higher temperature. EDX analysis verified the presence of C, O, Mg, Ni, and Ba, with higher C and Ba content in NBM600 and higher Mg and Ni content in NBM800. FE-SEM images revealed irregular porous aggregates for NBM600 and more compact polygonal or hexagonal grains for NBM800, while HR-TEM micrographs showed fine nearly spherical particles for NBM600 and larger faceted particles for NBM800. The maximum uptake capabilities reached 371.75 mg/g concerning NBM600 as well as 310.56 mg/g concerning NBM800. Thermodynamic evaluation indicated that dye sequestration is exothermic, spontaneous, and physical in nature. Also, kinetic and isotherm analyses demonstrated harmony with the pseudo-first-order model as well as Langmuir monolayer adsorption. Besides, both nanocomposites were efficiently regenerated by HCl and reused with only limited loss in performance, and they achieved efficient removal of basic red 46 from real wastewater.

碱性红46是一种阳离子偶氮染料，会对水生生态系统和人类健康造成严重风险，因为它是持久的、有色的，即使浓度很低也可能有毒。本文采用简便的Pechini溶胶-凝胶法，分别在600℃和800℃条件下合成了MgO/NiO/BaCO3/C纳米复合材料NBM600和NBM800，用于去除污染废水中的碱性红46。XRD谱图证实了MgO、NiO和BaCO3与碳的多相结晶，平均晶粒尺寸从NBM600的65.22 nm增加到NBM800的75.88 nm，反映了高温下结晶度的增强。EDX分析证实了C、O、Mg、Ni和Ba的存在，NBM600中C和Ba含量较高，NBM800中Mg和Ni含量较高。FE-SEM图像显示NBM600为不规则多孔聚集体，而NBM800为更致密的多边形或六边形颗粒，而HR-TEM显微图像显示NBM600为细小的近球形颗粒，而NBM800为较大的多面颗粒。NBM600和NBM800的最大吸收能力分别为371.75 mg/g和310.56 mg/g。热力学评价表明染料固存是放热的、自发的和物理的。动力学和等温线分析也证实了该吸附过程符合拟一阶模型和Langmuir单层吸附。此外，这两种纳米复合材料都能被HCl有效地再生并重复使用，性能损失很小，并且能有效地去除实际废水中的碱性红46。

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引用次数: 0

Valorization of rice straw-derived lignin into vanillin via oxidative depolymerization over Mo/ZSM-5 catalysts Mo/ZSM-5催化剂氧化解聚制香兰素的研究

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society

Pub Date : 2026-01-01 DOI: 10.1016/j.jics.2025.102384

Harits Atika Ariyanta , Siti Komalasari , Wirya Sarwana , Egi Agustian , Fusia Mirda Yanti , Maya Ismayati , Aurelia Cyntia Putri , Obie Farobie , Widya Fatriasari , Mahardika F. Rois

Rice straw, an abundant agricultural residue in Indonesia, contains significant lignin content that can be valorized into high-value aromatic compounds. Herein, lignin isolated via alkaline delignification was subjected to oxidative depolymerization using molybdenum-based catalysts (MoO₃ and MoPO) supported on ZSM-5. Structural analyses confirmed that the guaiacyl-rich, condensed nature of rice straw lignin posed inherent recalcitrance issues. Nonetheless, FTIR and GC–MS analyses of the depolymerization products confirmed the formation of carbonyl- and hydroxyl-containing aromatics, predominantly vanillin and acetovanillone. Quantitative evaluation revealed that the MoO₃/ZSM-5 and MoPO/ZSM-5 catalysts achieved vanillin yields of 5.60 % and 5.64 %, respectively, substantially surpassing those of the unsupported systems. XPS analysis demonstrated that the coexistence of multiple Mo oxidation states (Mo⁴⁺/Mo⁵⁺/Mo⁶⁺) facilitated selective β–O–4 bond scission, while the zeolite supported enhanced dispersion and porosity, enabling efficient substrate–catalyst interactions. These findings establish an efficient catalytic platform for converting recalcitrant lignin into vanillin, underscoring the potential of Mo/ZSM-5 systems to advance lignin valorization within a sustainable waste-to-value framework.

水稻秸秆是印度尼西亚丰富的农业残留物，含有大量木质素，可以转化为高价值的芳香化合物。本研究利用ZSM-5负载的钼基催化剂（MoO3和MoPO）对碱解木质素进行氧化解聚。结构分析证实，愈创木酰丰富，浓缩性质的稻草木质素造成固有的顽抗问题。尽管如此，FTIR和GC-MS对解聚产物的分析证实了羰基和羟基芳香烃的形成，主要是香兰素和乙酰香兰酮。定量评价表明，MoO3/ZSM-5和MoPO/ZSM-5催化剂的香兰素产率分别为5.60%和5.64%，大大超过无负载体系。XPS分析表明，多种Mo氧化态（Mo4+/Mo5+/Mo6+）的共存促进了β-O-4键的选择性断裂，而沸石支持增强的分散性和孔隙度，从而实现了高效的底物-催化剂相互作用。这些发现为将顽固性木质素转化为香兰素建立了一个有效的催化平台，强调了Mo/ZSM-5系统在可持续的废物转化价值框架内促进木质素增值的潜力。

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引用次数: 0

Sweeping away Cd(II) from aquatic systems using a C@BaO2@TiO2 nanosorbent 利用C@BaO2@TiO2纳米吸附剂清除水生系统中的Cd（II）

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society

Pub Date : 2026-01-01 DOI: 10.1016/j.jics.2025.102375

Abueliz Modwi , Hajo Idriss , Mohamed Ali Ben Aissa , Sulaiman Aloraini

This study evaluates the C@BaO₂@TiO₂ (CBOTO) nanocomposite for Cd(II) removal from aqueous solutions. CBOTO was synthesized via sonication and characterized by XRD, FTIR, BET, SEM-EDX, TEM, and XPS, confirming the intended composite and mesoporous morphology. Batch adsorption tests systematically examined the effects of pH, initial Cd(II) concentration, adsorbent dose, and contact time on the adsorption process. Equilibrium data were best described by the Freundlich model (multilayer adsorption), while the Langmuir fit yielded a maximum capacity of 472.9 mg g⁻¹. Kinetic analysis indicated a pseudo-first-order rate law with rapid uptake to near-equilibrium (68 min). Spectroscopic and mapping evidence, including the emergence of the Cd–O band in FTIR and Cd signals identified by EDX mapping, demonstrates that Cd(II) ions interact with oxygen-containing sites on the Ti–O–Ba framework. This supports a mechanism in which Cd(II) uptake occurs primarily through electrostatic attraction between Cd (II) ions and negatively charged surface oxygen atoms, followed by surface complexation that stabilizes the adsorbed Cd(II). CBOTO retained high performance in the presence of common coexisting ions and showed good regeneration (maintaining >90 % of its initial removal efficiency over multiple adsorption–desorption cycles). These findings highlight CBOTO as a promising, fast-acting, high-capacity nanosorbent for cadmium remediation in water.

本研究评价了C@BaO2@TiO2 （CBOTO）纳米复合材料对水溶液中Cd（II）的去除效果。通过超声波合成了CBOTO，并通过XRD、FTIR、BET、SEM-EDX、TEM和XPS对其进行了表征，证实了CBOTO的复合结构和介孔形貌。批量吸附试验系统地考察了pH、初始Cd（II）浓度、吸附剂剂量和接触时间对吸附过程的影响。平衡数据最好用Freundlich模型（多层吸附）来描述，而Langmuir拟合的最大容量为472.9 mg g−1。动力学分析显示准一阶速率规律，快速吸收至接近平衡（68 min）。光谱和作图证据，包括FTIR中Cd - o波段的出现和EDX作图识别的Cd信号，表明Cd（II）离子与Ti-O-Ba框架上的含氧位点相互作用。这支持了Cd（II）吸收主要通过Cd（II）离子和带负电荷的表面氧原子之间的静电吸引发生的机制，随后是表面络合作用，稳定吸附的Cd（II）。在常见共存离子存在的情况下，CBOTO保持了良好的性能，并表现出良好的再生能力（在多次吸附-解吸循环中保持了90%的初始去除效率）。这些发现突出了CBOTO作为一种有前途的、快速作用的、高容量的纳米吸附剂用于水中镉的修复。

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引用次数: 0

Targeting NDM-1 through in silico approaches: Discovery of potential inhibitors to overcome antimicrobial resistance 通过硅片方法靶向NDM-1：发现克服抗菌素耐药性的潜在抑制剂

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society

Pub Date : 2026-01-01 DOI: 10.1016/j.jics.2025.102395

Sayantan Pradhan , SK Jubayar Ahashan , Jyotirmayee Dash , Barada P. Dash

New Delhi Metallo-β-lactamase-1 (NDM-1) is a zinc-dependent β-lactamase responsible for antibiotic resistance through the hydrolysis of β-lactam antibiotics. Docking-based screening of 137 sulfonamide derivatives identified three lead compounds (M1–M3) with stronger binding affinities (−10.4 to −9.5 kcal/mol) than ampicillin (−8.6 kcal/mol). These ligands formed stable interactions with the catalytic zinc ions (ZN302 and ZN303) at the active site. Molecular dynamics simulations (200 ns) confirmed stable ligand-enzyme complexes with minimal RMSD fluctuations while HOMO-LUMO and ADMET analyses indicated favorable electronic properties and pharmacokinetics. M1-M3 therefore represent promising leads for inhibiting NDM-1-mediated antibiotic resistance. Among the identified leads, M1 exhibited the strongest binding and highest stability, emerging as the most promising inhibitor of NDM-1.

新德里金属β-内酰胺酶-1 （NDM-1）是一种锌依赖性β-内酰胺酶，通过水解β-内酰胺类抗生素产生抗生素耐药性。对137个磺酰胺衍生物进行对接筛选，发现3个先导化合物（M1-M3）的结合亲和力（- 10.4 ~ - 9.5 kcal/mol）高于氨苄西林（- 8.6 kcal/mol）。这些配体在活性位点与催化锌离子（ZN302和ZN303）形成稳定的相互作用。分子动力学模拟（200 ns）证实了稳定的配体-酶复合物具有最小的RMSD波动，而HOMO-LUMO和ADMET分析显示了良好的电子特性和药代动力学。因此，M1-M3代表了抑制ndm -1介导的抗生素耐药性的有希望的线索。在已确定的先导物中，M1表现出最强的结合性和最高的稳定性，成为最有希望的NDM-1抑制剂。

引用次数: 0

Development and validation of an eco-friendly RP-HPLC method for the quantification of lurasidone in complexed nano-formulation with forced degradation studies 生态友好型反相高效液相色谱（RP-HPLC）方法的建立与验证，用于鲁拉西酮在复杂纳米制剂中的定量及强制降解研究

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society

Pub Date : 2026-01-01 DOI: 10.1016/j.jics.2025.102372

Tushar Sirmaur, Arka Karmakar, Lalit Kumar

Lurasidone hydrochloride has limited water solubility and undergoes considerable first-pass metabolism, resulting in reduced oral bioavailability (<20 %). Encapsulating LRD into nano-carrier systems is an excellent approach to improve solubility and provide advantages such as targeted and sustained delivery, addressing limitations. The study focused on developing a straightforward, sensitive, and environmentally friendly HPLC analytical method for quantifying LRD in nanoformulations. Utilizing an analytical quality-by-design approach, an HPLC-based analytical method was developed using a C18 column and validated in accordance with ICH Q2(R1) guidelines. The mobile phase comprises an ammonium acetate buffer (30 mM) at pH 3.5, methanol, and acetonitrile in a ratio of 14:68:18, with an optimized flow rate of 0.82 mL/min. All analyses were conducted with a UV detector at 230 nm. A forced degradation study was conducted to assess the stability of LRD under various stress conditions. The optimized method demonstrated excellent linearity within the 0.5–4.0 μg/mL concentration range. The LOD and LOQ values of 40.48 and 122.68 ng/mL reflect the method's high sensitivity. The results of forced degradation indicated the stability of LRD under various conditions. Furthermore, the results from multiple greenness-assessment tools, including GAPI, complex-GAPI, AGREE, and BAGI, validate the greenness and practical applicability of the improved technique.

盐酸鲁拉西酮水溶性有限，首过代谢相当大，导致口服生物利用度降低（20%）。将LRD封装到纳米载体系统中是一种极好的方法，可以提高其溶解度，并具有靶向和持续递送等优点，解决了局限性。本研究的重点是建立一种简单、灵敏、环保的高效液相色谱分析方法来定量纳米制剂中的LRD。采用基于设计的分析质量方法，采用C18色谱柱建立了基于高效液相色谱的分析方法，并根据ICH Q2（R1）指南进行了验证。流动相包括pH为3.5的醋酸铵缓冲液（30 mM）、甲醇和乙腈，比例为14:68:18，优化流速为0.82 mL/min。所有分析均采用230 nm紫外检测器进行。进行了强制降解研究，以评估LRD在各种应力条件下的稳定性。优化后的方法在0.5 ~ 4.0 μg/mL浓度范围内线性良好。LOD和LOQ分别为40.48和122.68 ng/mL，反映了该方法的高灵敏度。强迫降解的结果表明LRD在不同条件下的稳定性。此外，包括GAPI、complex-GAPI、AGREE和BAGI在内的多个绿色度评估工具的结果验证了改进技术的绿色度和实用性。

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引用次数: 0

Design and characterization of acacia gum –graft- polyacrylamide polymer based sustained release metformin HCl tablets 金合欢胶接枝聚丙烯酰胺聚合物基盐酸二甲双胍缓释片的设计与表征

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society

Pub Date : 2026-01-01 DOI: 10.1016/j.jics.2025.102387

Gita Sahu , Shashikant Chandrakar , Sanjib Bahadur

Objective

Main object of this research is formulation of a metformin sustained released tablet used with AG-g-PAM (Acacia gum-g-Polyacrylamide).

Methods

At first Acacia gum grafted with Polyacrylamide was synthesized with convention technique using CAS as a redox initiator and characterized by FTIR,SEM, XRD and swelling index study.

Result

The polymerization and grafting of AG-g-PAM successfully completed is analyzed by by FTIR, which identified characteristic functional groups, including shifts in amide and hydroxyl peaks, indicating that grafting interactions between acacia gum and polyacrylamide is good. XRD analysis revealed the amorphous nature of the composite, with changes in partially crystalline attributed to the grafting process. SEM method reveals a rough, porous surface structure, which increases the material's capacity to absorb more water and potential for adsorption applications. Acute oral toxicity studies was done according to OECD guideline 425 and and Histopathology studies was carried. The formulation of different batch of tablet were optimized by central composite design 2³ using Design expert software 13 version. Than 14 batches of 500 mg tablet were prepared using dry granulation method and grafted polymer as a excipients and evaluated the sustained released tablet such as hardness, thickness, friability, In vitro drug release studies. The F3 and F4 batch was dedicate the sustained released.98 % of durg were released over a period of 8hr in the 6.8 pH Phosphate buffer. as compare the drug released of tablet with native gum was 99 % drug released within the 1hr approx.

Conclusion

Tablets prepared with pure polymer exhibited rapid drug released whereas tablet made with grafted polymer show sustained drug released.

目的研究二甲双胍缓释片与AG-g-PAM（金合欢胶-g-聚丙烯酰胺）联用的处方。方法以CAS为氧化还原引发剂，采用常规工艺合成了第一次聚丙烯酰胺接枝的金合树胶，并通过FTIR、SEM、XRD和膨胀指数研究对其进行了表征。结果通过FTIR对成功完成的AG-g-PAM的聚合和接枝过程进行了分析，鉴定出了典型的官能团，包括酰胺峰和羟基峰的移位，表明金合木与聚丙烯酰胺的接枝相互作用良好。XRD分析揭示了复合材料的非晶性质，部分结晶的变化归因于接枝过程。扫描电镜方法揭示了粗糙的多孔表面结构，这增加了材料吸收更多水的能力和吸附应用的潜力。急性口服毒性研究是根据经合组织指南425进行的，并进行了组织病理学研究。采用设计专家软件13版，采用中心组合设计23对不同批次片剂的处方进行优化。采用干造粒法制备14批500 mg片剂，接枝聚合物为辅料，对其进行硬度、厚度、脆性等缓释片的评价，并进行体外释药研究。F3和F4批专用于持续释放。98%的药物在6.8 pH的磷酸盐缓冲液中释放8小时。与天然口香糖相比，片剂在约1小时内释药率为99%。结论纯聚合物制备的片剂释药速度快，接枝聚合物制备的片剂释药时间长。

{"title":"Design and characterization of acacia gum –graft- polyacrylamide polymer based sustained release metformin HCl tablets","authors":"Gita Sahu , Shashikant Chandrakar , Sanjib Bahadur","doi":"10.1016/j.jics.2025.102387","DOIUrl":"10.1016/j.jics.2025.102387","url":null,"abstract":"<div><h3>Objective</h3><div>Main object of this research is formulation of a metformin sustained released tablet used with AG-g-PAM (Acacia gum-g-Polyacrylamide).</div></div><div><h3>Methods</h3><div>At first Acacia gum grafted with Polyacrylamide was synthesized with convention technique using CAS as a redox initiator and characterized by FTIR,SEM, XRD and swelling index study.</div></div><div><h3>Result</h3><div>The polymerization and grafting of AG-g-PAM successfully completed is analyzed by by FTIR, which identified characteristic functional groups, including shifts in amide and hydroxyl peaks, indicating that grafting interactions between acacia gum and polyacrylamide is good. XRD analysis revealed the amorphous nature of the composite, with changes in partially crystalline attributed to the grafting process. SEM method reveals a rough, porous surface structure, which increases the material's capacity to absorb more water and potential for adsorption applications. Acute oral toxicity studies was done according to OECD guideline 425 and and Histopathology studies was carried. The formulation of different batch of tablet were optimized by central composite design 2<sup>3</sup> using Design expert software 13 version. Than 14 batches of 500 mg tablet were prepared using dry granulation method and grafted polymer as a excipients and evaluated the sustained released tablet such as hardness, thickness, friability, In vitro drug release studies. The F3 and F4 batch was dedicate the sustained released.98 % of durg were released over a period of 8hr in the 6.8 pH Phosphate buffer. as compare the drug released of tablet with native gum was 99 % drug released within the 1hr approx.</div></div><div><h3>Conclusion</h3><div>Tablets prepared with pure polymer exhibited rapid drug released whereas tablet made with grafted polymer show sustained drug released.</div></div>","PeriodicalId":17276,"journal":{"name":"Journal of the Indian Chemical Society","volume":"103 2","pages":"Article 102387"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145928413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential solubilization and zeolite-assisted fermentation of macroalgae: A sustainable route for biohydrogen generation 大型藻类的顺序增溶和沸石辅助发酵：生物制氢的可持续途径

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society

Pub Date : 2025-12-31 DOI: 10.1016/j.jics.2025.102396

Shabarish S , Tamilarasan K , Godvin Sharmila V

This study explores an energy-efficient and cost-effective method called hydrophobins-availed sonic solubilization (HSS), combined with zeolite 13X-aided anaerobic fermentation (AF) (zeolite 13X + HSS), to enhance biohydrogen production from marine macroalgae biomass (MMB), specifically Chaetomorpha antennina. Sonic solubilization (SS) was optimized by varying sonic intensity (20–70 %) and solubilization time (5–60 min). The optimum conditions—50 % intensity for 30 mins—produced a solubilized organics release (SOR) of 2710 mg/L and a solubilization efficiency (SE) of 21 %. Under these conditions, HSS was performed with hydrophobins dosages ranging from 0.0 to 4.5 g/g total solids (TS). A dosage of 1.5 g/g TS was optimal, achieving 25.5 % SE and 3300 mg/L SOR. In AF, a zeolite 13X dosage of 200 mg/g TS resulted in the highest biohydrogen yield due to the balancing capacity of adsorption, buffering, nutrient availability, and microbial attachment. HSS led to greater volatile fatty acid (VFA) production (1785 mg/L) compared to SS (824 mg/L), and a higher energy ratio (1.7 vs. 0.7). The Zeolite 13X + HSS method produced a maximum of 211 mL H₂/g COD. Economically, it delivered a net profit of $112.24, surpassing Zeolite 13X + SS ($54). These findings confirm that Zeolite 13X + HSS is a superior strategy for efficient and economical biohydrogen production from MMB.

本研究探索了一种高效、经济的方法，称为疏水素利用声波增溶（HSS），结合沸石13X辅助厌氧发酵（AF）（沸石13X + HSS），以提高海洋大型藻类生物量（MMB）的生物产氢量，特别是毛藻。通过改变超声强度（20 ~ 70%）和增溶时间（5 ~ 60 min），优化了超声增溶效果。最佳条件为50%的强度30 min，可产生2710 mg/L的增溶有机物释放量（SOR）和21%的增溶效率（SE）。在这些条件下，疏水蛋白的剂量范围为0.0至4.5 g/g总固体（TS）。最佳剂量为1.5 g/g TS， SE为25.5%，SOR为3300 mg/L。在AF中，沸石13X用量为200 mg/g TS，由于吸附、缓冲、养分有效性和微生物附着的平衡能力，生物氢产量最高。与SS （824 mg/L）相比，HSS的挥发性脂肪酸（VFA）产量更高（1785 mg/L），能量比更高（1.7 vs 0.7）。沸石13X + HSS法最大COD为211 mL H2/g。经济上，它实现了112.24美元的净利润，超过了沸石13X + SS（54美元）。这些发现证实了沸石13X + HSS是一种高效、经济的从MMB生产生物氢的优越策略。

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引用次数: 0

Taguchi-optimized eco-friendly treatment of Sansevieria trifasciata fibers using liquid smoke and microwave heating for enhanced composite properties 田口优化的三叶草纤维的液体烟和微波加热的环保处理，以提高复合材料的性能

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society

Pub Date : 2025-12-31 DOI: 10.1016/j.jics.2025.102393

Muhammad Arsyad Suyuti , Rusdi Nur , Ahmad Nurul Muttaqin , Djarot B. Darmadi , Dahlang Tahir

This study presents an eco-friendly, statistically optimized approach to enhancing the mechanical and structural properties of Sansevieria trifasciata fibers (STF) for sustainable composite applications. The treatment combines coconut shell liquid smoke (CS-LS) soaking and microwave heating, optimized using the Taguchi method. The primary treatment factors, soaking time, heating temperature, and heating duration, were optimized to improve the mechanical, morphological, and thermal properties of STF. The optimal conditions 120 min of CS-LS soaking and microwave heating at 40 °C for 30 min resulted in a 33 % increase in tensile strength, from 269.82 MPa (untreated) to 358.87 MPa (treated). Characterization through SEM, FTIR, XRD, TGA, and DSC revealed significant changes in the fiber's morphology, chemical structure, crystallinity, and thermal stability. SEM analysis showed enhanced surface roughness and porosity, while FTIR indicated reduced hydroxyl and lignin content. XRD analysis confirmed an increase in the crystallinity index from 50.72 % to 80.91 %. TGA and DSC analysis demonstrated improved thermal stability and reactivity. These findings validate the effectiveness of the Taguchi-optimized treatment in improving STF's properties, positioning them as promising reinforcement materials for high-performance, environmentally friendly composites.

本研究提出了一种生态友好的、统计优化的方法来提高三叶桑叶纤维（STF）的机械和结构性能，以实现可持续复合材料的应用。采用椰壳液烟（CS-LS）浸泡和微波加热相结合的处理方法，采用田口法进行优化。通过对浸泡时间、加热温度和加热时间等主要处理因素的优化，提高了STF的力学性能、形貌和热性能。最佳工艺条件为CS-LS浸泡120 min， 40℃微波加热30 min，拉伸强度从269.82 MPa（未处理）提高到358.87 MPa（处理），提高了33%。通过SEM、FTIR、XRD、TGA和DSC表征，发现纤维的形态、化学结构、结晶度和热稳定性发生了显著变化。扫描电镜分析显示表面粗糙度和孔隙度增加，红外光谱分析显示羟基和木质素含量降低。XRD分析证实结晶度指数从50.72%提高到80.91%。TGA和DSC分析表明其热稳定性和反应性得到改善。这些发现验证了taguchi优化处理在改善STF性能方面的有效性，将其定位为高性能、环保复合材料的有前途的增强材料。

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引用次数: 0

A one-pot four-component, synthetic strategy for coumarin-fused 1,2,3,4-tetrahydropyrimidines with promising antimicrobial activities 一锅四组分合成香豆素融合1,2,3,4-四氢嘧啶，具有良好的抗菌活性

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society

Pub Date : 2025-12-30 DOI: 10.1016/j.jics.2025.102391

Tara Rangrime A. Sangma, Shunan Kaping, Jai Narain Vishwakarma

In the present study, a series of 3-(alkyl/aralkyl/aryl)-3,4-dihydro-1H-chromeno[4,3-d]pyrimidin-5(2H)-one derivatives was designed and synthesized via a multicomponent one-pot strategy, and their potential as antimicrobial agents was explored. The coumarin-fused 1,2,3,4-tetrahydropyrimidines were generated through the reaction of 4-aminocoumarin with primary amines and formaldehyde in methanol/AcOH, providing good to high yields. Spectral analyses – IR, ¹H & ¹³C NMR, and MS or HR-MS confirmed the formation of the anticipated structural frameworks. The compounds 4a–4j were assessed for antibacterial and antifungal activities against clinically relevant fungal pathogens. The coumarin-fused pyrimidine derivatives demonstrated moderate activity, though their efficacy was lower compared to the reference drugs. Compounds 4a, 4h, 4i, and 4j exhibited potential inhibition across the tested microorganisms.

本研究采用多组分一锅法设计并合成了一系列3-（烷基/芳烷基/芳基）-3,4-二氢- 1h -色[4,3-d]嘧啶-5(2H)- 1衍生物，并探索了它们作为抗菌药物的潜力。通过4-氨基香豆素与伯胺和甲醛在甲醇/AcOH中反应，得到了香豆素融合的1,2,3,4-四氢嘧啶，收率较高。光谱分析-红外，1H & 13C核磁共振，质谱或HR-MS证实了预期结构框架的形成。化合物4a-4j对临床相关真菌病原体的抗菌和抗真菌活性进行了评估。香豆素融合嘧啶衍生物显示出适度的活性，但其功效低于对照药物。化合物4a、4h、4i和4j在被测微生物中表现出潜在的抑制作用。

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引用次数: 0

Synergistic impact of Gd3+ doped CaCO3/PEG nanocomposites for dye degradation and antibacterial functionalities Gd3+掺杂CaCO3/PEG纳米复合材料对染料降解和抗菌功能的协同影响

IF 3.4 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Indian Chemical Society

Pub Date : 2025-12-30 DOI: 10.1016/j.jics.2025.102392

E. Thenpandiyan , V. Ramasamy , G. Suresh , T. Sathishpriya , S. Senthil

A series of Gd-doped CaCO₃/PEG nanocomposites were successfully synthesized via a simple biomimetic route. The nanocomposites were comprehensively characterized for their structural, functional, optical, thermal, elemental, and morphological properties. FTIR (461 cm⁻¹, Gd–O) and XRD analyses confirmed the successful incorporation of Gd³⁺ into the CaCO₃ matrix, with crystallite sizes ranging between 29 and 23 nm. Optical studies using UV–Vis DRS and photoluminescence spectra revealed a blue shift and a gradual increase in bandgap energy (from 4.12 to 4.70 eV) with increasing Gd concentration. XPS analysis further confirmed the substitution of Gd³⁺ ions into the CaCO₃ lattice, showing well-resolved peaks corresponding to Ca 2p, C 1s, O 1s, and Gd 4d. FE-SEM and HR-TEM imaging revealed spherical and rhombohedral-like morphologies, highlighting uniform dispersion within the PEG matrix. Among the series, the GCP₁ nanocomposite demonstrated outstanding photocatalytic efficiency, achieving 86 % (k = 3.23 × 10⁻³min⁻¹, and R² = 0.9599) degradation of Methylene Blue (MB) dye within 90 min under UV irradiation. A scavenger-based trapping study was conducted to elucidate the active species involved in the degradation mechanism. In terms of biological efficacy, the GCP₄ nanocomposite exhibited remarkable antibacterial activity, producing zones of inhibition of 17 mm and 13 mm against Staphylococcus aureus (Gram-positive) and Salmonella sp. (Gram-negative), respectively, at a concentration of 1000 μg/mL. Overall, the synthesized Gd-doped CaCO₃/PEG nanocomposites, with tunable properties based on Gd content, show great promise as multifunctional materials for environmental remediation and antibacterial applications, supported by their efficacy, stability, and biocompatibility.

通过简单的仿生方法成功合成了一系列gd掺杂CaCO3/PEG纳米复合材料。对纳米复合材料的结构、功能、光学、热、元素和形态等性能进行了全面表征。FTIR （461 cm−1,Gd-O）和XRD分析证实了Gd3+成功结合到CaCO3基体中，晶粒尺寸在29 ~ 23 nm之间。利用UV-Vis DRS和光致发光光谱进行的光学研究表明，随着Gd浓度的增加，带隙能量逐渐增加（从4.12 eV增加到4.70 eV），并发生蓝移。XPS分析进一步证实了Gd3+离子取代到CaCO3晶格中，显示出对应于Ca 2p， C 1s， O 1s和Gd 4d的良好分辨峰。FE-SEM和HR-TEM成像显示球形和菱形样形态，突出PEG基质内均匀分散。其中，GCP1纳米复合材料表现出优异的光催化效率，在紫外线照射下90 min内对亚甲基蓝（MB）染料的降解率达到86% （k = 3.23 × 10−3min−1,R2 = 0.9599）。为了阐明参与降解机制的活性物种，进行了基于食腐动物的捕集研究。在生物功效方面，GCP4纳米复合材料表现出显著的抗菌活性，在浓度为1000 μg/mL时，对金黄色葡萄球菌（革兰氏阳性）和沙门氏菌（革兰氏阴性）分别产生17 mm和13 mm的抑制区。总的来说，所合成的Gd掺杂CaCO3/PEG纳米复合材料具有基于Gd含量可调的性能，具有良好的功效、稳定性和生物相容性，在环境修复和抗菌方面具有广阔的应用前景。

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引用次数: 0