S. Esmat, M. Assaf, D. Kadry, M. E. El Hawary, D. Halim, Marwa Saleh, D. Bassiouny, Heba Saad, Ghada M. El-Hanafy
Background Melanocyte keratinocyte transplantation procedure (MKTP) is a multi-procedural intervention that could hypothetically alter the environment surrounding grafted epidermal cells, helping melanocytes’ migration and adherence to keratinocytes in their basal position. Objective To evaluate the effect of MKTP in acral vitiligo skin prepared by total ablative CO2 laser resurfacing and followed by narrow-band ultraviolet B (NB-UVB) phototherapy on matrix metalloproteinase-2 (MMP2) and E-Cadherin expression and the reflection of these changes on repigmentation. Patients and methods Acral lesions in 20 stable nonsegmental vitiligo patients were prepared by full CO2 ablation down to the papillary dermis followed by MKTP and NB-UVB sessions. Two 4 mm punch biopsies were taken: the first at baseline and the second after the onset of repigmentation or after 6 months of phototherapy if no repigmentation occurred. Immunohistochemical staining for evaluation of E-Cadherin and MMP2 expression was performed. Results Eight patients (40%) achieved repigmentation ranging from 10 to 90% with a median of 62.5%. E-Cadherin intensity was significantly increased after treatment (P<00.1). There was also a significant total increase in epidermal (P<0.001) and dermal (P<0.001) MMP2 with diffuse nuclear pattern of staining. In lesions showing repigmentations, the percentage change in dermal MMP2 was significantly higher (P=0.012), while no such difference was present in epidermal MMP2 and E-Cadherin expression. Conclusion MKTP with recipient site prepared by full CO2 laser ablation followed by NB-UVB phototherapy increased the expression of E-Cadherin and MMP2 in acral vitiliginous skin. The increase of dermal MMP2 could play a favorable role in repigmentation.
{"title":"Effect of melanocyte keratinocyte transplantation procedure, using ablative CO2 laser and followed by NB-UVB phototherapy, on the expression of E-Cadherin and matrix metalloproteinase-2 in acral vitiligo: an immunohistochemical study","authors":"S. Esmat, M. Assaf, D. Kadry, M. E. El Hawary, D. Halim, Marwa Saleh, D. Bassiouny, Heba Saad, Ghada M. El-Hanafy","doi":"10.4103/jewd.jewd_15_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_15_21","url":null,"abstract":"Background Melanocyte keratinocyte transplantation procedure (MKTP) is a multi-procedural intervention that could hypothetically alter the environment surrounding grafted epidermal cells, helping melanocytes’ migration and adherence to keratinocytes in their basal position. Objective To evaluate the effect of MKTP in acral vitiligo skin prepared by total ablative CO2 laser resurfacing and followed by narrow-band ultraviolet B (NB-UVB) phototherapy on matrix metalloproteinase-2 (MMP2) and E-Cadherin expression and the reflection of these changes on repigmentation. Patients and methods Acral lesions in 20 stable nonsegmental vitiligo patients were prepared by full CO2 ablation down to the papillary dermis followed by MKTP and NB-UVB sessions. Two 4 mm punch biopsies were taken: the first at baseline and the second after the onset of repigmentation or after 6 months of phototherapy if no repigmentation occurred. Immunohistochemical staining for evaluation of E-Cadherin and MMP2 expression was performed. Results Eight patients (40%) achieved repigmentation ranging from 10 to 90% with a median of 62.5%. E-Cadherin intensity was significantly increased after treatment (P<00.1). There was also a significant total increase in epidermal (P<0.001) and dermal (P<0.001) MMP2 with diffuse nuclear pattern of staining. In lesions showing repigmentations, the percentage change in dermal MMP2 was significantly higher (P=0.012), while no such difference was present in epidermal MMP2 and E-Cadherin expression. Conclusion MKTP with recipient site prepared by full CO2 laser ablation followed by NB-UVB phototherapy increased the expression of E-Cadherin and MMP2 in acral vitiliginous skin. The increase of dermal MMP2 could play a favorable role in repigmentation.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"179 - 185"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44645230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Azza G A Farag, H. Abdallah, R. Ibrahem, M. Elshaib, W. Shehata
Background The metabolism and immune system are linked via a network of many mediators known as adipokines. Ghrelin and apelin-36 are unique adipokines; however, their role in psoriasis, an immune-mediated disease, remains unclear. Objective To detect the serum levels of ghrelin and apelin-36 in psoriasis vulgaris patients in comparison with controls and to correlate their levels with severity of psoriasis, BMI, lipid profile, and glycated hemoglobin (HbA1c). Patients and methods The present case–control study included 70 nonobese psoriasis vulgaris patients and 70 controls. The severity of psoriasis was assessed using the psoriasis area and severity index score. The ghrelin and apelin-36 serum levels, cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and HbA1c were measured. Results Psoriatic patients had significantly higher ghrelin (P<0.001), HbA1c (P<0.001), cholesterol (P<0.001), triglycerides (P<0.001), and low-density lipoprotein (P=0.001) levels and a lower apelin-36 (P<0.001) serum level than controls. Serum ghrelin was negatively correlated with psoriasis area and severity index score (r=−0.75; P<0.001), whereas serum apelin-36 was negatively correlated with HbA1c mean values (r=−0.44; P=0.004) and was found to be a good predictor of prediabetes in psoriatic patients (P=0.012). Nonsignificant correlation between ghrelin and apelin-36 serum levels was observed in psoriatic patients. Conclusion Ghrelin and apelin-36 are dynamic adipokines that might play a role in psoriasis vulgaris pathogenesis. The role of ghrelin and apelin-36 in psoriasis might be mediated through dyslipidemia and impaired glucose metabolism in psoriatic patients, respectively. Targeting both ghrelin and apelin-36 may be of value in management of metabolic syndrome associated with psoriasis. Serum apelin-36 assessment can predict prediabetic state in psoriatic patients.
{"title":"Circulating ghrelin and apelin levels in nonobese psoriasis vulgaris patients","authors":"Azza G A Farag, H. Abdallah, R. Ibrahem, M. Elshaib, W. Shehata","doi":"10.4103/jewd.jewd_35_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_35_21","url":null,"abstract":"Background The metabolism and immune system are linked via a network of many mediators known as adipokines. Ghrelin and apelin-36 are unique adipokines; however, their role in psoriasis, an immune-mediated disease, remains unclear. Objective To detect the serum levels of ghrelin and apelin-36 in psoriasis vulgaris patients in comparison with controls and to correlate their levels with severity of psoriasis, BMI, lipid profile, and glycated hemoglobin (HbA1c). Patients and methods The present case–control study included 70 nonobese psoriasis vulgaris patients and 70 controls. The severity of psoriasis was assessed using the psoriasis area and severity index score. The ghrelin and apelin-36 serum levels, cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, and HbA1c were measured. Results Psoriatic patients had significantly higher ghrelin (P<0.001), HbA1c (P<0.001), cholesterol (P<0.001), triglycerides (P<0.001), and low-density lipoprotein (P=0.001) levels and a lower apelin-36 (P<0.001) serum level than controls. Serum ghrelin was negatively correlated with psoriasis area and severity index score (r=−0.75; P<0.001), whereas serum apelin-36 was negatively correlated with HbA1c mean values (r=−0.44; P=0.004) and was found to be a good predictor of prediabetes in psoriatic patients (P=0.012). Nonsignificant correlation between ghrelin and apelin-36 serum levels was observed in psoriatic patients. Conclusion Ghrelin and apelin-36 are dynamic adipokines that might play a role in psoriasis vulgaris pathogenesis. The role of ghrelin and apelin-36 in psoriasis might be mediated through dyslipidemia and impaired glucose metabolism in psoriatic patients, respectively. Targeting both ghrelin and apelin-36 may be of value in management of metabolic syndrome associated with psoriasis. Serum apelin-36 assessment can predict prediabetic state in psoriatic patients.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"198 - 204"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45114495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Eldarouti, H. Rasheed, A. M. Eltawdy, P. Mostafa
Mycosis fungoides (MF) is a great imitator. It can resemble more than 50 different clinical disorders. Porokeratosis is the rarest of the disorders and has been reported only in three cases. Herein, we present three cases of porokeratosis occurring in MF patients. The first case proved to be MF lesions upon histopathological examination, whereas the second case showed a classic porokeratosis occurring in association with MF in the same lesion. Finally, the third case was presented with classic porokeratosis that developed in a longstanding MF case undergoing treatment with Methotrexate and PUVA.
{"title":"Porokeratosis and mycosis fungoides: cause/result or an association or neither? A case report","authors":"M. Eldarouti, H. Rasheed, A. M. Eltawdy, P. Mostafa","doi":"10.4103/jewd.jewd_13_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_13_21","url":null,"abstract":"Mycosis fungoides (MF) is a great imitator. It can resemble more than 50 different clinical disorders. Porokeratosis is the rarest of the disorders and has been reported only in three cases. Herein, we present three cases of porokeratosis occurring in MF patients. The first case proved to be MF lesions upon histopathological examination, whereas the second case showed a classic porokeratosis occurring in association with MF in the same lesion. Finally, the third case was presented with classic porokeratosis that developed in a longstanding MF case undergoing treatment with Methotrexate and PUVA.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"215 - 218"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48827297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Valle, Daniel López, A. Velázquez, Carmen Donoso
The authors present the unusual case of a 21-year-old woman, who, during the fourth month of her first pregnancy, developed asymptomatic lesions on abdominal distension striae. On physical examination, she presented erythematous–violaceous nodules, of a fibrous consistency, superimposed on atrophic whitish linear plaques along the abdomen, flanks, and lumbar region. A skin biopsy was performed that confirmed the clinical suspicion of hypertrophic scars on striae distensae. Over the biopsy wound, a keloid scar also developed. The authors have found previous case reports of queloid recurrence during pregnancy, but none about hypertrophic scars on stretch marks of pregnancy. However, it appears that the relationship between hormonal factors during pregnancy and the tendency toward abnormal scarring is well established.
{"title":"Hypertrophic striae gravidarum as an eruptive dermatosis of pregnancy","authors":"A. Valle, Daniel López, A. Velázquez, Carmen Donoso","doi":"10.4103/jewd.jewd_27_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_27_21","url":null,"abstract":"The authors present the unusual case of a 21-year-old woman, who, during the fourth month of her first pregnancy, developed asymptomatic lesions on abdominal distension striae. On physical examination, she presented erythematous–violaceous nodules, of a fibrous consistency, superimposed on atrophic whitish linear plaques along the abdomen, flanks, and lumbar region. A skin biopsy was performed that confirmed the clinical suspicion of hypertrophic scars on striae distensae. Over the biopsy wound, a keloid scar also developed. The authors have found previous case reports of queloid recurrence during pregnancy, but none about hypertrophic scars on stretch marks of pregnancy. However, it appears that the relationship between hormonal factors during pregnancy and the tendency toward abnormal scarring is well established.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"222 - 224"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48281414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashraf M. Hamza, R. A. Abo Elwafa, N. Ramadan, S. Omar
Background IL17F rs763780 polymorphism results in substitution of histidine to arginine at amino acid 161, leading to upregulation of IL17F and increased propensity to autoimmune diseases. The single nucleotide polymorphism rs2275913 (G197A) involves a substitution of the guanine by an adenine nucleotide base in IL17A gene promotor which plays a key role in regulation of cytokine transcription. The relation of IL17 polymorphisms however to psoriasis risk and response to methotrexate has not been previously studied in Egyptians. Objective To study the relation of IL17A (rs2275913 G>A) and IL17F (rs2397084 T>C) polymorphisms to psoriasis risk and assess their predictive role regarding response to methotrexate. Patients and methods The study was conducted in two phases. First, a case–control study including 100 patients with chronic plaque psoriasis and 100 healthy control patients was conducted for IL17A (rs2275913) and IL17F (rs2397084) polymorphisms by real-time PCR. Second, a cohort study was adopted where the patients with psoriasis were treated with methotrexate weekly intramuscularly (0.6 mg/kg) for 12 weeks and followed for clinical response. Results IL17F TT genotype was more frequent in patients (87%) than controls (68%), whereas TC genotype was more frequent in controls (32%) than patients (13%). TT genotype was associated with increased risk of psoriasis, whereas the TC allele was associated with a decreased risk. There was no significant difference regarding IL17A GG, GA, and AA genotype frequencies between patients and controls. Psoriasis area and severity index greater than or equal to 75% was achieved in 22 patients (73.3%) with the TT genotype and eight patients (26.7%) with TC genotype (P=0.019). Conclusion IL17F (rs2397084 T>C) TT genotype could be considered a susceptibility marker in Egyptian patients. Psoriatic patients with TT genotype and T allele of IL17F (rs2397084 T>C) are likely to show a better response to methotrexate.
{"title":"Il17A (rs2275913 G>A) and IL17F (rs2397084 T>C) gene polymorphisms: relation to psoriasis risk and response to methotrexate","authors":"Ashraf M. Hamza, R. A. Abo Elwafa, N. Ramadan, S. Omar","doi":"10.4103/jewd.jewd_6_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_6_21","url":null,"abstract":"Background IL17F rs763780 polymorphism results in substitution of histidine to arginine at amino acid 161, leading to upregulation of IL17F and increased propensity to autoimmune diseases. The single nucleotide polymorphism rs2275913 (G197A) involves a substitution of the guanine by an adenine nucleotide base in IL17A gene promotor which plays a key role in regulation of cytokine transcription. The relation of IL17 polymorphisms however to psoriasis risk and response to methotrexate has not been previously studied in Egyptians. Objective To study the relation of IL17A (rs2275913 G>A) and IL17F (rs2397084 T>C) polymorphisms to psoriasis risk and assess their predictive role regarding response to methotrexate. Patients and methods The study was conducted in two phases. First, a case–control study including 100 patients with chronic plaque psoriasis and 100 healthy control patients was conducted for IL17A (rs2275913) and IL17F (rs2397084) polymorphisms by real-time PCR. Second, a cohort study was adopted where the patients with psoriasis were treated with methotrexate weekly intramuscularly (0.6 mg/kg) for 12 weeks and followed for clinical response. Results IL17F TT genotype was more frequent in patients (87%) than controls (68%), whereas TC genotype was more frequent in controls (32%) than patients (13%). TT genotype was associated with increased risk of psoriasis, whereas the TC allele was associated with a decreased risk. There was no significant difference regarding IL17A GG, GA, and AA genotype frequencies between patients and controls. Psoriasis area and severity index greater than or equal to 75% was achieved in 22 patients (73.3%) with the TT genotype and eight patients (26.7%) with TC genotype (P=0.019). Conclusion IL17F (rs2397084 T>C) TT genotype could be considered a susceptibility marker in Egyptian patients. Psoriatic patients with TT genotype and T allele of IL17F (rs2397084 T>C) are likely to show a better response to methotrexate.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"167 - 173"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45453776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Zayed, Rasha Abelghafar, Ahmed Hehazy, Sarah Orabi, M. El-Mesidy
Background Challenging treatment of acne scars makes it a must to have a plan for each case specifically. Subcision breaks the fibrous strands tethering the scar but is followed by recurrence. Chemical peeling and microneedling are other treatment options. Objectives To evaluate a new subcision technique combined with either microneedling or peeling in the treatment of acne scars. Patients and methods A total of 20 patients with bilateral rolling and boxcar acne scars were enrolled. Subcision using microkeratomes was done followed by either peeling using 35% trichloroacetic acid on one side or microneedling on the other side. Evaluation of response was done by Echelle d’Evaluation clinique des Cicatrices d’acné grading scale and optical coherence tomography imaging. Results Both therapeutic modalities yielded statistically significant improvement of acne scars and statistically significant decrease in acne scar depth. There was neither a statistically significant difference between the two sides regarding Echelle d’Evaluation clinique des Cicatrices d’acné scoring after treatment (P=0.968) nor regarding optical coherence tomography acne scar depth after treatment (P=0.583). Conclusion This novel technique of subcision is a safe and effective method for rolling and boxcar scar treatment, with almost no adverse effects and no downtime. In addition, trichloroacetic acid 35% peel is cheaper, as well as does not need any extensive special training or expensive instruments, as compared with microneedling, but microneedling shows better skin tightness and improvement of skin elastolysis especially in older patients.
背景痤疮疤痕的治疗具有挑战性，因此必须针对每种情况制定具体的计划。皮下切除术使束缚疤痕的纤维束断裂，但随后会复发。化学去皮和微针是其他治疗选择。目的评价一种新的皮下切除技术结合微针或去皮治疗痤疮疤痕。患者和方法共20例双侧滚动痤疮和箱形痤疮疤痕患者。使用微型角膜刀进行皮下切除，然后在一侧使用35%三氯乙酸去皮或在另一侧使用微针。通过Echelle d’Evaluation clinicique des Cicatrices d’acné分级量表和光学相干断层扫描成像对反应进行评估。结果两种治疗方式均能显著改善痤疮疤痕，并显著降低痤疮疤痕深度。双方在治疗后的Echelle d’Evaluation clinicique des Cicatrices d’acné评分（P=0.968）和治疗后的光学相干断层扫描痤疮疤痕深度（P=0.583）方面均无统计学差异，几乎没有不良影响，也没有停机时间。此外，与微针相比，35%三氯乙酸果皮更便宜，也不需要任何广泛的特殊训练或昂贵的仪器，但微针显示出更好的皮肤紧密性和改善皮肤弹性溶解，尤其是在老年患者中。
{"title":"Novel subcision technique combined with either microneedling or trichloroacetic acid 35% peeling for acne scars: a comparative study","authors":"A. Zayed, Rasha Abelghafar, Ahmed Hehazy, Sarah Orabi, M. El-Mesidy","doi":"10.4103/jewd.jewd_58_20","DOIUrl":"https://doi.org/10.4103/jewd.jewd_58_20","url":null,"abstract":"Background Challenging treatment of acne scars makes it a must to have a plan for each case specifically. Subcision breaks the fibrous strands tethering the scar but is followed by recurrence. Chemical peeling and microneedling are other treatment options. Objectives To evaluate a new subcision technique combined with either microneedling or peeling in the treatment of acne scars. Patients and methods A total of 20 patients with bilateral rolling and boxcar acne scars were enrolled. Subcision using microkeratomes was done followed by either peeling using 35% trichloroacetic acid on one side or microneedling on the other side. Evaluation of response was done by Echelle d’Evaluation clinique des Cicatrices d’acné grading scale and optical coherence tomography imaging. Results Both therapeutic modalities yielded statistically significant improvement of acne scars and statistically significant decrease in acne scar depth. There was neither a statistically significant difference between the two sides regarding Echelle d’Evaluation clinique des Cicatrices d’acné scoring after treatment (P=0.968) nor regarding optical coherence tomography acne scar depth after treatment (P=0.583). Conclusion This novel technique of subcision is a safe and effective method for rolling and boxcar scar treatment, with almost no adverse effects and no downtime. In addition, trichloroacetic acid 35% peel is cheaper, as well as does not need any extensive special training or expensive instruments, as compared with microneedling, but microneedling shows better skin tightness and improvement of skin elastolysis especially in older patients.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"109 - 118"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48199701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Podoplanin (PDPN) is a specific marker for lymphatic endothelial cells; however, it can be expressed by many other cells including renal podocytes. In dermatology, PDPN has been involved in diverse disorders, such as tumor lymphangiogenesis, as well as in immune-mediated disorders. Herein, we illustrate and discuss the landscape of PDPN in dermatology.
{"title":"The landscape of ‘podoplanin’ in dermatology: a narrative review","authors":"N. Diab, M. Assaf, Nourhan Anis, E. Salah","doi":"10.4103/jewd.jewd_18_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_18_21","url":null,"abstract":"Podoplanin (PDPN) is a specific marker for lymphatic endothelial cells; however, it can be expressed by many other cells including renal podocytes. In dermatology, PDPN has been involved in diverse disorders, such as tumor lymphangiogenesis, as well as in immune-mediated disorders. Herein, we illustrate and discuss the landscape of PDPN in dermatology.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"81 - 88"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47584570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashraf M. Hamza, Mona Aiad, Ahmed Abdel-Bary, Eman Gouda
Background Interleukin 15 (IL15) is a proinflammatory cytokine that is involved in the pathogenesis of several autoimmune and inflammatory diseases. The stability of vitiligo represents the periods of no activity of the disease, and it is crucial in determining the line of treatment of the patient. Objective To assess serum IL15 in patients with vitiligo and to evaluate its predictive capacity as a marker of vitiligo activity. Patients and methods A total of 40 patients with nonsegmental vitiligo were included, in addition to 30 age-matched and sex-matched healthy individuals as a control. The severity of vitiligo was assessed using vitiligo area severity index score, whereas the activity of disease in patients was assessed using vitiligo disease activity score. Serum levels of IL15 were measured using the ELISA technique. Results The mean serum level of IL15 was significantly higher in patients with vitiligo (201.14±115.41 ng/l) than in control (136.13±22.57 ng/l). Moreover, the mean serum level of IL15 was significantly higher in patients with unstable/active vitiligo (243.12±136.64 ng/l) than in patients with stable vitiligo (144.35±28.82 ng/l). Patients with serum level of less than or equal to 150.90 ng/l can be diagnosed as stable vitiligo, with 76.47% sensitivity and 73.91% specificity. Conclusion IL15 is a good and reliable marker for the detection of activity in patients with vitiligo, but further studies are needed to follow the progression of disease and to correlate this with the serum level of IL15. Targeting IL15 could be a novel treatment approach for patients with vitiligo.
{"title":"Serum interleukin 15 as a marker of activity in patients with vitiligo","authors":"Ashraf M. Hamza, Mona Aiad, Ahmed Abdel-Bary, Eman Gouda","doi":"10.4103/jewd.jewd_60_20","DOIUrl":"https://doi.org/10.4103/jewd.jewd_60_20","url":null,"abstract":"Background Interleukin 15 (IL15) is a proinflammatory cytokine that is involved in the pathogenesis of several autoimmune and inflammatory diseases. The stability of vitiligo represents the periods of no activity of the disease, and it is crucial in determining the line of treatment of the patient. Objective To assess serum IL15 in patients with vitiligo and to evaluate its predictive capacity as a marker of vitiligo activity. Patients and methods A total of 40 patients with nonsegmental vitiligo were included, in addition to 30 age-matched and sex-matched healthy individuals as a control. The severity of vitiligo was assessed using vitiligo area severity index score, whereas the activity of disease in patients was assessed using vitiligo disease activity score. Serum levels of IL15 were measured using the ELISA technique. Results The mean serum level of IL15 was significantly higher in patients with vitiligo (201.14±115.41 ng/l) than in control (136.13±22.57 ng/l). Moreover, the mean serum level of IL15 was significantly higher in patients with unstable/active vitiligo (243.12±136.64 ng/l) than in patients with stable vitiligo (144.35±28.82 ng/l). Patients with serum level of less than or equal to 150.90 ng/l can be diagnosed as stable vitiligo, with 76.47% sensitivity and 73.91% specificity. Conclusion IL15 is a good and reliable marker for the detection of activity in patients with vitiligo, but further studies are needed to follow the progression of disease and to correlate this with the serum level of IL15. Targeting IL15 could be a novel treatment approach for patients with vitiligo.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"104 - 108"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43778231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can patients with urticaria be contagious to COVID-19? a new disguise: a hypothesis from an Egyptian experience","authors":"P. Mostafa","doi":"10.4103/jewd.jewd_8_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_8_21","url":null,"abstract":"","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"157 - 158"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43156704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. El-Enany, Khaled El Hoshy, R. Youssef, N. Nagui, H. Nada, M. Halim, A. Nada, Dina Elantably, Iman Sany
Fluoroscopy-induced chronic radiodermatitis is a rare complication that is now encountered more often owing to the increasing use of fluoroscopy in radiological procedures. The long duration between radiation exposure and development of condition, patient unawareness of exposure to radiation along with lack of clinical suspicion of the condition among dermatologists, all make the diagnosis difficult. We report three cases of male patients who presented with a clinical picture suggestive of fluoroscopy-induced chronic radiodermatitis backed up by history of cardiac catheterization procedures confirming the diagnosis. Awareness of this entity among dermatologists is important for early recognition and proper management.
{"title":"Fluoroscopy-induced chronic radiodermatitis: three cases presenting after cardiac catheterization","authors":"G. El-Enany, Khaled El Hoshy, R. Youssef, N. Nagui, H. Nada, M. Halim, A. Nada, Dina Elantably, Iman Sany","doi":"10.4103/jewd.jewd_67_20","DOIUrl":"https://doi.org/10.4103/jewd.jewd_67_20","url":null,"abstract":"Fluoroscopy-induced chronic radiodermatitis is a rare complication that is now encountered more often owing to the increasing use of fluoroscopy in radiological procedures. The long duration between radiation exposure and development of condition, patient unawareness of exposure to radiation along with lack of clinical suspicion of the condition among dermatologists, all make the diagnosis difficult. We report three cases of male patients who presented with a clinical picture suggestive of fluoroscopy-induced chronic radiodermatitis backed up by history of cardiac catheterization procedures confirming the diagnosis. Awareness of this entity among dermatologists is important for early recognition and proper management.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"153 - 156"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49619379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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