Herviani Sari, Vera Estefania Kaban, Friska Raulina Situmorang, Firdaus Fahdi
Background : Diabetes mellitus (DM) is a chronic disease caused by the body's inability to produce the hormone insulin or due to ineffective use of insulin production. Diabetes has become a global problem, DM prevalence of 4.6%, estimated in 2000 amounted to 5.6 million. One of the plants that can reduce blood glucose levels is meniran and rosella which are found in Indonesia. Objective : To determine the effect of decreasing blood glucose levels in white rats using a combination of meniran and rosella compared to glibenclamide.Method : This research was carried out experimentally. Simplicia of meniran leaves and rosella macerated using 80% ethanol. The research used 21 rats that were induced by alloxan and divided into 7 groups and all compared using glibenclamide.Group 1 (negative control) CMC Na 1%, group 2 (positive control) glibenclamide dose 0.45 mg / kgBB, group 3 single roselle extract dose 130 mg / kgBB, group 4 single meniran leaf extract dose 200 mg / kgBB, group 5 combination of meniran leaf extract dose of 100 mg / kgBB and rosella extract dose of 65 mg / kgBB, group 6 combination of meniran leaf extract dose of 200 mg / kgBB and rosella extract dose of 130 mg / kgBB, and group 7 meniran leaf extract combination dose 400 mg / kgBB and rosella extract dose 195 mg / kgBB. Result : The results showed that rats had hyperglycemia after being induced by alloxan.Data were analyzed using one way ANOVA method followed by LSD and tukeys' B post hoct test. Having a difference in the decrease in blood glucose levels between the positive control group and the five doses of meniran extract and rosella where p <0.05 gave a significant effect compared to the negative control group p> 0.05 did not have a significant effect in reducing blood glucose levels. Conclusion : Single meniran extract and high-dose combination extract are more effective than glibenclamide.
{"title":"UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) pada TIKUS JANTAN PUTIH SEBAGAI HEWAN PERCOBAAN","authors":"Herviani Sari, Vera Estefania Kaban, Friska Raulina Situmorang, Firdaus Fahdi","doi":"10.36656/jpfh.v2i1.204","DOIUrl":"https://doi.org/10.36656/jpfh.v2i1.204","url":null,"abstract":"Background : Diabetes mellitus (DM) is a chronic disease caused by the body's inability to produce the hormone insulin or due to ineffective use of insulin production. Diabetes has become a global problem, DM prevalence of 4.6%, estimated in 2000 amounted to 5.6 million. One of the plants that can reduce blood glucose levels is meniran and rosella which are found in Indonesia. Objective : To determine the effect of decreasing blood glucose levels in white rats using a combination of meniran and rosella compared to glibenclamide.Method : This research was carried out experimentally. Simplicia of meniran leaves and rosella macerated using 80% ethanol. The research used 21 rats that were induced by alloxan and divided into 7 groups and all compared using glibenclamide.Group 1 (negative control) CMC Na 1%, group 2 (positive control) glibenclamide dose 0.45 mg / kgBB, group 3 single roselle extract dose 130 mg / kgBB, group 4 single meniran leaf extract dose 200 mg / kgBB, group 5 combination of meniran leaf extract dose of 100 mg / kgBB and rosella extract dose of 65 mg / kgBB, group 6 combination of meniran leaf extract dose of 200 mg / kgBB and rosella extract dose of 130 mg / kgBB, and group 7 meniran leaf extract combination dose 400 mg / kgBB and rosella extract dose 195 mg / kgBB. Result : The results showed that rats had hyperglycemia after being induced by alloxan.Data were analyzed using one way ANOVA method followed by LSD and tukeys' B post hoct test. Having a difference in the decrease in blood glucose levels between the positive control group and the five doses of meniran extract and rosella where p <0.05 gave a significant effect compared to the negative control group p> 0.05 did not have a significant effect in reducing blood glucose levels. Conclusion : Single meniran extract and high-dose combination extract are more effective than glibenclamide.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81910381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The bacteria Mycobacterium tuberculosis causes tuberculosis. That bacteria is a very strong bacterium, so it should used some antibiotics to kill the bacteria. Tuberculosis (TB) treatment has two stages of intensive and advanced stages. To improve the compliance of TB, patients generally use anti-tuberculosis drugs (OAT) a fixed-dose combination. In the intensive stage, there are at least four antibiotics in the OAT combines fixed-dose. The use of polypharmacy drugs leads to the onset of unwanted side effects and is one of the causes of tuberculosis patients to stop treatment. The purpose of this research is analyzing the side effects that occur during the treatment of anti-tuberculosis. Sampling techniques performed in a prospective observation of tuberculosis patients who consume OAT for two months with analysis using statistics. The results of the study are the most frequent adverse effects on OAT are itching, headache and nausea with a percentage of each 72%, joint pain 45%, abdominal pain 36.4%, less appetite and rash respectively 27,3% and reddish colour in the urine 18.2 %.
{"title":"ANALISIS DESKRIPTIF EFEK SAMPING PENGGUNAAN OBAT ANTI TUBERCULOSIS PADA PASIEN TBC DI RSUD Dr. PIRNGADI MEDAN","authors":"E. S. Dasopang, Fenni Hasanah, Chairul Nisak","doi":"10.36656/jpfh.v2i1.180","DOIUrl":"https://doi.org/10.36656/jpfh.v2i1.180","url":null,"abstract":"The bacteria Mycobacterium tuberculosis causes tuberculosis. That bacteria is a very strong bacterium, so it should used some antibiotics to kill the bacteria. Tuberculosis (TB) treatment has two stages of intensive and advanced stages. To improve the compliance of TB, patients generally use anti-tuberculosis drugs (OAT) a fixed-dose combination. In the intensive stage, there are at least four antibiotics in the OAT combines fixed-dose. The use of polypharmacy drugs leads to the onset of unwanted side effects and is one of the causes of tuberculosis patients to stop treatment. The purpose of this research is analyzing the side effects that occur during the treatment of anti-tuberculosis. Sampling techniques performed in a prospective observation of tuberculosis patients who consume OAT for two months with analysis using statistics. The results of the study are the most frequent adverse effects on OAT are itching, headache and nausea with a percentage of each 72%, joint pain 45%, abdominal pain 36.4%, less appetite and rash respectively 27,3% and reddish colour in the urine 18.2 %.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89000842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To determine the effectiveness of pain reduction and hemodynamic response using a 30 mg lidocaine and 20 μg/kg of BB in the thirty seconds before propofol induction in general anesthesia with endotracheal intubation. Methods: This study has a double-blind clinical test design. A total of 140 ASA-1 and ASA-2 patients who would undergo surgery with general anesthesia techniques used propofol induction and were taken by Endotraskea to obtain one of the two groups. Thirty seconds before propofol induction, the group I is by adding lidocaine 30 mg, while the group II is by adding the ephedrine 20μg/KgMW thirty seconds before propofol induction. Assess the value of VAS at the time of injection of the first three cc propofol with an injection speed of 15-18 seconds. Systolic, diastolic blood pressure, MAP, and heart rate are recorded before premedication (baseline), after premedication, after administration of ephedrine, after induction of propofol and the 1st minute, 3.5 after intubation. Statistical tests conducted with Chi-Square, Mann-Whitney, and Independent T-Test tests. Result: The comparison of the pain incidence rate between the two groups is the same as the value of VAS 0-3 in both groups. Indicate a meaningful difference in the ephedrine group 20 μg/KgMW obtained a median value of visual analog scale 0, 64.3% while VAS 1-3 as much as 35.7% in group Lidocaine 30 mg obtained by the median value of visual analog scale 0, 47.1% While at VAS 1-3 as much as 52.9%. The average arterial pressure of the ephedrine group is 30 seconds after the injection of propofol, 83 (73-91) mmHg, which is significantly higher when compared with the average arterial pressure of the group Lidocaine 30 mg, 74 (68-85) mmHg. Arterial pressure at 1, 3, and 5 min after intubation in the ephedrine group consistently demonstrated a significantly higher value than the arterial pressure of the lidocaine group. Conclusion: Ephedrine 20 μg/KgMW and 30 mg lidocaine are equally effective in terms of pain reduction due to propofol induction. Ephedrine 20 μg/KgMW provides a lesser effect of hemodynamic changes in the injection of general anesthesia with endotracheal intubation.
{"title":"EFEKTIFITAS EPHEDRINE 20 µg/KgBB DIBANDINGKAN DENGAN LIDOKAIN 30 mg TERHADAP NYERI DAN RESPON HEMODINAMIK AKIBAT PENYUNTIKAN PROPOFOL PADA ANESTESIA UMUM DENGAN INTUBASI ENDOTRAKEA","authors":"Dody Firmanda","doi":"10.36656/jpfh.v2i1.206","DOIUrl":"https://doi.org/10.36656/jpfh.v2i1.206","url":null,"abstract":"\u0000Purpose: To determine the effectiveness of pain reduction and hemodynamic response using a 30 mg lidocaine and 20 μg/kg of BB in the thirty seconds before propofol induction in general anesthesia with endotracheal intubation. Methods: This study has a double-blind clinical test design. A total of 140 ASA-1 and ASA-2 patients who would undergo surgery with general anesthesia techniques used propofol induction and were taken by Endotraskea to obtain one of the two groups. Thirty seconds before propofol induction, the group I is by adding lidocaine 30 mg, while the group II is by adding the ephedrine 20μg/KgMW thirty seconds before propofol induction. Assess the value of VAS at the time of injection of the first three cc propofol with an injection speed of 15-18 seconds. Systolic, diastolic blood pressure, MAP, and heart rate are recorded before premedication (baseline), after premedication, after administration of ephedrine, after induction of propofol and the 1st minute, 3.5 after intubation. Statistical tests conducted with Chi-Square, Mann-Whitney, and Independent T-Test tests. Result: The comparison of the pain incidence rate between the two groups is the same as the value of VAS 0-3 in both groups. Indicate a meaningful difference in the ephedrine group 20 μg/KgMW obtained a median value of visual analog scale 0, 64.3% while VAS 1-3 as much as 35.7% in group Lidocaine 30 mg obtained by the median value of visual analog scale 0, 47.1% While at VAS 1-3 as much as 52.9%. The average arterial pressure of the ephedrine group is 30 seconds after the injection of propofol, 83 (73-91) mmHg, which is significantly higher when compared with the average arterial pressure of the group Lidocaine 30 mg, 74 (68-85) mmHg. Arterial pressure at 1, 3, and 5 min after intubation in the ephedrine group consistently demonstrated a significantly higher value than the arterial pressure of the lidocaine group. Conclusion: Ephedrine 20 μg/KgMW and 30 mg lidocaine are equally effective in terms of pain reduction due to propofol induction. Ephedrine 20 μg/KgMW provides a lesser effect of hemodynamic changes in the injection of general anesthesia with endotracheal intubation.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81583845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aims to find out: whether the use of video is more effective than using audio in improving students' pharmacists 'speaking skills. Find out whether the use of video is more effective than general media use in improving students' speaking skills. Whether audio usage more effective rather than using conventional media in improving students 'speaking skills. Find out which media is the most effective among the use of Video, Audio, and conventional media on improving students' speaking skills. This research is an experimental study using Quasi Pretest Post-test Control Group design. The research sample was students pharmacist class 1A, 1B, and 1C taken by a simple cluster random sampling technique. This research shows that video usage is the most effective medium among all of them, and the use of video is more effective than using audio in improving students ' speaking skills.
{"title":"PENGARUH MEDIA AUDIO DAN VIDEO TERHADAP MAHASISWA PROGRAM STUDI FARMASI DALAM KEMAMPUAN BERBICARA DI INSTITUT KESEHATAN DELI HUSADA DELI TUA","authors":"Mona Fitri Gurusinga","doi":"10.36656/jpfh.v2i1.208","DOIUrl":"https://doi.org/10.36656/jpfh.v2i1.208","url":null,"abstract":"This study aims to find out: whether the use of video is more effective than using audio in improving students' pharmacists 'speaking skills. Find out whether the use of video is more effective than general media use in improving students' speaking skills. Whether audio usage more effective rather than using conventional media in improving students 'speaking skills. Find out which media is the most effective among the use of Video, Audio, and conventional media on improving students' speaking skills. This research is an experimental study using Quasi Pretest Post-test Control Group design. The research sample was students pharmacist class 1A, 1B, and 1C taken by a simple cluster random sampling technique. This research shows that video usage is the most effective medium among all of them, and the use of video is more effective than using audio in improving students ' speaking skills.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"167 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83530637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The discovery of new antibiotic drugs is getting more and more reactive. The plant of the peria laut leaf is one of the drugs that is often used as a traditional medicine and contains bioactive compounds of polyphenols, flavonoids, and saponins, which can inhibit antibacterial growth. Purpose of this study was to determine the antibacterial activity of ethanol extract of peria laut leaves (Colubrina asiatica L.) against Staphylococcus aureus and Escherichia coli bacteria. Method the experimental, of the sample used was concentrated marine peria laut leaf extract of 25mg/ml, 50mg/ml, 75mg/ml, 100mg/ml, 200mg/ml, 300mg/ml, 400mg/ml, and 500mg/ml, positive control of amoxicillin tablet 500 mg, negative control of dimethylsulfoxide with the method of disc diffusion testing using media Nutrient Agar. Results the showed thet the peria laut leaf extract positively contained bioactive alkaloid compounds, flavonoids, saponins, steroids, and tannins, and had inhibitory effects on Staphylococcus aureus and Escgerichia coli bacteria with various concentrations which had been tested on the average area of the highest inhibition zone of 18,6 mm in Staphylococcus aureus bacteria, and 10,2 mm in Escherichia coli bacteria. Conclusion peria laut leaf extract (Colubrina asiatica L.) has antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria in the most inhibitory zone at a concentration of 500mg/ml with a diameter of 18,6 in Staphylococcus aureus bacteria and 10,2 in Escherichia coli.
{"title":"UJI AKTIVITAS ANTIBAKTERI DARI EKSTRAK ETANOL DAUN PERIA LAUT (Colubrina Asiatica L.) TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS DAN ESCHERICHIA COLI","authors":"F. Fahdi, Harwitavia Harwitavia, Herviani Sari","doi":"10.36656/jpfh.v2i1.201","DOIUrl":"https://doi.org/10.36656/jpfh.v2i1.201","url":null,"abstract":"The discovery of new antibiotic drugs is getting more and more reactive. The plant of the peria laut leaf is one of the drugs that is often used as a traditional medicine and contains bioactive compounds of polyphenols, flavonoids, and saponins, which can inhibit antibacterial growth. Purpose of this study was to determine the antibacterial activity of ethanol extract of peria laut leaves (Colubrina asiatica L.) against Staphylococcus aureus and Escherichia coli bacteria. Method the experimental, of the sample used was concentrated marine peria laut leaf extract of 25mg/ml, 50mg/ml, 75mg/ml, 100mg/ml, 200mg/ml, 300mg/ml, 400mg/ml, and 500mg/ml, positive control of amoxicillin tablet 500 mg, negative control of dimethylsulfoxide with the method of disc diffusion testing using media Nutrient Agar. Results the showed thet the peria laut leaf extract positively contained bioactive alkaloid compounds, flavonoids, saponins, steroids, and tannins, and had inhibitory effects on Staphylococcus aureus and Escgerichia coli bacteria with various concentrations which had been tested on the average area of the highest inhibition zone of 18,6 mm in Staphylococcus aureus bacteria, and 10,2 mm in Escherichia coli bacteria. Conclusion peria laut leaf extract (Colubrina asiatica L.) has antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria in the most inhibitory zone at a concentration of 500mg/ml with a diameter of 18,6 in Staphylococcus aureus bacteria and 10,2 in Escherichia coli.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89435329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To determine the effectiveness of pain reduction and hemodynamic response using a 30 mg lidocaine and 20 μg/kg of BB in the thirty seconds before propofol induction in general anesthesia with endotracheal intubation. Methods: This study has a double-blind clinical test design. A total of 140 ASA-1 and ASA-2 patients who would undergo surgery with general anesthesia techniques used propofol induction and were taken by Endotraskea to obtain one of the two groups. Thirty seconds before propofol induction, the group I is by adding lidocaine 30 mg, while the group II is by adding the ephedrine 20μg/KgMW thirty seconds before propofol induction. Assess the value of VAS at the time of injection of the first three cc propofol with an injection speed of 15-18 seconds. Systolic, diastolic blood pressure, MAP, and heart rate are recorded before premedication (baseline), after premedication, after administration of ephedrine, after induction of propofol and the 1st minute, 3.5 after intubation. Statistical tests conducted with Chi-Square, Mann-Whitney, and Independent T-Test tests. Result: The comparison of the pain incidence rate between the two groups is the same as the value of VAS 0-3 in both groups. Indicate a meaningful difference in the ephedrine group 20 μg/KgMW obtained a median value of visual analog scale 0, 64.3% while VAS 1-3 as much as 35.7% in group Lidocaine 30 mg obtained by the median value of visual analog scale 0, 47.1% While at VAS 1-3 as much as 52.9%. The average arterial pressure of the ephedrine group is 30 seconds after the injection of propofol, 83 (73-91) mmHg, which is significantly higher when compared with the average arterial pressure of the group Lidocaine 30 mg, 74 (68-85) mmHg. Arterial pressure at 1, 3, and 5 min after intubation in the ephedrine group consistently demonstrated a significantly higher value than the arterial pressure of the lidocaine group. Conclusion: Ephedrine 20 μg/KgMW and 30 mg lidocaine are equally effective in terms of pain reduction due to propofol induction. Ephedrine 20 μg/KgMW provides a lesser effect of hemodynamic changes in the injection of general anesthesia with endotracheal intubation.
{"title":"EFEKTIFITAS EPHEDRINE 20 μg/KgBB DIBANDINGKAN DENGAN LIDOKAIN 30 mg TERHADAP NYERI DAN RESPON HEMODINAMIK AKIBAT PENYUNTIKAN PROPOFOL PADA ANESTESIA UMUM DENGAN INTUBASI ENDOTRAKEA","authors":"Dody Firmanda","doi":"10.36656/jpfh.v2i1.81","DOIUrl":"https://doi.org/10.36656/jpfh.v2i1.81","url":null,"abstract":"Purpose: To determine the effectiveness of pain reduction and hemodynamic response using a 30 mg lidocaine and 20 μg/kg of BB in the thirty seconds before propofol induction in general anesthesia with endotracheal intubation. Methods: This study has a double-blind clinical test design. A total of 140 ASA-1 and ASA-2 patients who would undergo surgery with general anesthesia techniques used propofol induction and were taken by Endotraskea to obtain one of the two groups. Thirty seconds before propofol induction, the group I is by adding lidocaine 30 mg, while the group II is by adding the ephedrine 20μg/KgMW thirty seconds before propofol induction. Assess the value of VAS at the time of injection of the first three cc propofol with an injection speed of 15-18 seconds. Systolic, diastolic blood pressure, MAP, and heart rate are recorded before premedication (baseline), after premedication, after administration of ephedrine, after induction of propofol and the 1st minute, 3.5 after intubation. Statistical tests conducted with Chi-Square, Mann-Whitney, and Independent T-Test tests. Result: The comparison of the pain incidence rate between the two groups is the same as the value of VAS 0-3 in both groups. Indicate a meaningful difference in the ephedrine group 20 μg/KgMW obtained a median value of visual analog scale 0, 64.3% while VAS 1-3 as much as 35.7% in group Lidocaine 30 mg obtained by the median value of visual analog scale 0, 47.1% While at VAS 1-3 as much as 52.9%. The average arterial pressure of the ephedrine group is 30 seconds after the injection of propofol, 83 (73-91) mmHg, which is significantly higher when compared with the average arterial pressure of the group Lidocaine 30 mg, 74 (68-85) mmHg. Arterial pressure at 1, 3, and 5 min after intubation in the ephedrine group consistently demonstrated a significantly higher value than the arterial pressure of the lidocaine group. Conclusion: Ephedrine 20 μg/KgMW and 30 mg lidocaine are equally effective in terms of pain reduction due to propofol induction. Ephedrine 20 μg/KgMW provides a lesser effect of hemodynamic changes in the injection of general anesthesia with endotracheal intubation.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82094728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Herviani Sari, Vera Estefania Kaban, Friska Raulina Situmorang, Firdaus Fahdi
Purpose: To determine the effect of decreasing blood glucose levels in white rats using a combination of meniran and rosella compared to glibenclamide. Method: This research was carried out experimentally. Simplicia of meniran leaves and rosella macerated using 80% ethanol. The research used 21 rats that were induced by alloxan and divided into 7 groups and all compared using glibenclamide.Group 1 (negative control) CMC Na 1%, group 2 (positive control) glibenclamide dose 0.45 mg/kgMB, group 3 single roselle extract dose 130 mg/kgMB, group 4 single meniran leaf extract dose 200 mg/kgMB, group 5 combination of meniran leaf extract dose of 100 mg/kgMB and rosella extract dose of 65 mg/kgMB, group 6 combination of meniran leaf extract dose of 200 mg/kgMB and rosella extract dose of 130 mg/kgMB, and group 7 meniran leaf extract combination dose 400 mg/kgMB and rosella extract dose 195 mg/kgMB. Result: The results showed that rats had hyperglycemia after being induced by alloxan.Data were analyzed using one way ANOVA method followed by LSD and tukeys' B post hoct test. Having a difference in the decrease in blood glucose levels between the positive control group and the five doses of meniran extract and rosella gave a significant effect compared to the negative control group did not have a significant effect in reducing blood glucose levels. Conclusion: Single meniran extract and high-dose combination extract are more effective than glibenclamide.
{"title":"UJI EFEKTIVITAS ANTIDIABETES KOMBINASI EKSTRAK DAUN MENIRAN (Phyllanthus niruri L.) Dan KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS JANTAN PUTIH","authors":"Herviani Sari, Vera Estefania Kaban, Friska Raulina Situmorang, Firdaus Fahdi","doi":"10.36656/jpfh.v2i1.79","DOIUrl":"https://doi.org/10.36656/jpfh.v2i1.79","url":null,"abstract":"Purpose: To determine the effect of decreasing blood glucose levels in white rats using a combination of meniran and rosella compared to glibenclamide. Method: This research was carried out experimentally. Simplicia of meniran leaves and rosella macerated using 80% ethanol. The research used 21 rats that were induced by alloxan and divided into 7 groups and all compared using glibenclamide.Group 1 (negative control) CMC Na 1%, group 2 (positive control) glibenclamide dose 0.45 mg/kgMB, group 3 single roselle extract dose 130 mg/kgMB, group 4 single meniran leaf extract dose 200 mg/kgMB, group 5 combination of meniran leaf extract dose of 100 mg/kgMB and rosella extract dose of 65 mg/kgMB, group 6 combination of meniran leaf extract dose of 200 mg/kgMB and rosella extract dose of 130 mg/kgMB, and group 7 meniran leaf extract combination dose 400 mg/kgMB and rosella extract dose 195 mg/kgMB. Result: The results showed that rats had hyperglycemia after being induced by alloxan.Data were analyzed using one way ANOVA method followed by LSD and tukeys' B post hoct test. Having a difference in the decrease in blood glucose levels between the positive control group and the five doses of meniran extract and rosella gave a significant effect compared to the negative control group did not have a significant effect in reducing blood glucose levels. Conclusion: Single meniran extract and high-dose combination extract are more effective than glibenclamide.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82065932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zaim Anshari, C. Ginting, L. Chiuman, Yuliani Mardiati Lubis
Objective: to determine the effect of mangosteen peel extract (Garcinia mangostana Linn) on ileal peristalsis separate male guinea pigs as diarrhea. Results: t-independent test, the difference: Contraction of ileum Acethlcholin with Atropine + Acethylcholin is 6.333 compared to Acethylcholin with extract + Acethylcholin is 8,500 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The t-independent test results are the difference: Contraction of ileum Histamine with Diphenhidramine + Histamine is 8.333 compared to Histamine with extract + Histamine is 10.833 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The results of the t-independent test are the difference: Contraction of the Barrium ileum with Papaverine + Barrium is 2,500 compared to the contraction of Barrium ileum with extract + Barrium is 2,500 with ANOVA test P value meaning that there is no difference between the two contractions of the ileum. From the three experimental groups, it was concluded that the extract worked similar to Papaverine. Cecilia's study, fruit skin extract can be used as diarrhea in Diare Effect of Mangosteen Ethanol Extract of Oleum ricini-induced Webster Swiss Mice.
{"title":"PENGARUH EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana Linn) TERHADAP PERISTALTIK ILEUM TERPISAH MARMOT JANTAN SEBAGAI ANTI DIARE","authors":"Zaim Anshari, C. Ginting, L. Chiuman, Yuliani Mardiati Lubis","doi":"10.36656/jpfh.v2i1.73","DOIUrl":"https://doi.org/10.36656/jpfh.v2i1.73","url":null,"abstract":"Objective: to determine the effect of mangosteen peel extract (Garcinia mangostana Linn) on ileal peristalsis separate male guinea pigs as diarrhea. Results: t-independent test, the difference: Contraction of ileum Acethlcholin with Atropine + Acethylcholin is 6.333 compared to Acethylcholin with extract + Acethylcholin is 8,500 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The t-independent test results are the difference: Contraction of ileum Histamine with Diphenhidramine + Histamine is 8.333 compared to Histamine with extract + Histamine is 10.833 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The results of the t-independent test are the difference: Contraction of the Barrium ileum with Papaverine + Barrium is 2,500 compared to the contraction of Barrium ileum with extract + Barrium is 2,500 with ANOVA test P value meaning that there is no difference between the two contractions of the ileum. From the three experimental groups, it was concluded that the extract worked similar to Papaverine. Cecilia's study, fruit skin extract can be used as diarrhea in Diare Effect of Mangosteen Ethanol Extract of Oleum ricini-induced Webster Swiss Mice.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79350039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Research on the tobacco leaves nicotine alkaloid (Nicotiana tobacum L) transdermal patch formulation has been carried out as a cigarette dependence therapy with variations in polymers and oleic acid as a penetration enhancer. The purpose of this study is to formulate a stable transdermal patch of nicotine alkaloid tobacco leaf and to see the effect of adding cellulose, PVP and oleic acid to the release of nicotine in vitro. Transdermal patch formulation consists of nicotine alkaloid tobacco leaf, PVP, ethyl cellulose, PVP, PEG 400, propylenglycol and oleic acid. In this study, 3 formulas were made with concentration variants of PVP: EC namely F1 = 1: 1, F2 = 1: 2, and F3 = 1: 3, where the variations in penetration enhancements in the form of oleic acid were F1: 0.10, F2: 0.15, and F3: 0.20. Evaluation of transdermal patch preparations includes organoleptic, matrix weight test, matrix thickness test, drying shrinkage percentage, moisture uptake, matrix fold resistance test, skin irritation test, patch matrix surface pH test, elongation percentage, frezee and thaw test, nicotine content test, and nicotine release (diffusion cell) test, based on physical stability test of all relatively stable transdermal patch formulas and kinetics of transdermal patch release kinetics following first order and the results of statistical analysis using Variant Analysis (ANOVA) showed differences in F1, F2 and F3, and based on the Korsmayer Peppas test following the non-fick law
{"title":"FORMULASI DAN EVALUAI STABILITAS FISIK PATCH TRANSDERMAL ALKALOID NIKOTIN DAUN TEMBAKAU (Nicotiana tobacum Linn) DENGAN VARIASI POLIMER DAN ASAM OLEAT","authors":"Adi Nurmesa, N. Nurhabibah, A. Najihudin","doi":"10.36656/jpfh.v2i1.150","DOIUrl":"https://doi.org/10.36656/jpfh.v2i1.150","url":null,"abstract":"Research on the tobacco leaves nicotine alkaloid (Nicotiana tobacum L) transdermal patch formulation has been carried out as a cigarette dependence therapy with variations in polymers and oleic acid as a penetration enhancer. The purpose of this study is to formulate a stable transdermal patch of nicotine alkaloid tobacco leaf and to see the effect of adding cellulose, PVP and oleic acid to the release of nicotine in vitro. Transdermal patch formulation consists of nicotine alkaloid tobacco leaf, PVP, ethyl cellulose, PVP, PEG 400, propylenglycol and oleic acid. In this study, 3 formulas were made with concentration variants of PVP: EC namely F1 = 1: 1, F2 = 1: 2, and F3 = 1: 3, where the variations in penetration enhancements in the form of oleic acid were F1: 0.10, F2: 0.15, and F3: 0.20. Evaluation of transdermal patch preparations includes organoleptic, matrix weight test, matrix thickness test, drying shrinkage percentage, moisture uptake, matrix fold resistance test, skin irritation test, patch matrix surface pH test, elongation percentage, frezee and thaw test, nicotine content test, and nicotine release (diffusion cell) test, based on physical stability test of all relatively stable transdermal patch formulas and kinetics of transdermal patch release kinetics following first order and the results of statistical analysis using Variant Analysis (ANOVA) showed differences in F1, F2 and F3, and based on the Korsmayer Peppas test following the non-fick law","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81384934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zaim Anshari, C. Ginting, L. Chiuman, Yuliani Mardiati Lubis
This study aims to determine whether mangosteen rind extract (in the form of ethanol extract/EE) can be used as an anti-diarrhea drug after compared with other anti-diarrhea substances in three experimental groups. This research is an in vitro experimental study using adult male guinea pigs weighing 400-600 gr through the standard method of Magnus with the Latin square controlled experiment design. The study was conducted at the Pharmacology and Toxicology Laboratory of the Faculty of Pharmacy, University of North Sumatra. The results showed that the contraction of ileum in Ach with Atp + Ach compared the difference in contraction of ileum Ach with EE + Ach showed the difference in difference between the two contractions of the ileum was significant, the contraction of ileum in His with Dip + His compared indifference in contraction of ileum His with EE + His showed a difference indifference. the two ileal contractions are significant, the ileal contraction in the bar with Papa + Bar compared to the difference between the ileum bar contraction with EE + Bar shows no difference in the difference between the two ileum contractions. The conclusion is that the Mangosteen Skin Ethanol Extract works similarly to Papaverine Hydrochloride which is an antidiarrheal drug used to relax smooth muscles so that it can also make blood vessels dilate by relaxing smooth muscles in the walls of blood vessels.
{"title":"EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana L.) SEBAGAI OBAT ANTI DIARE","authors":"Zaim Anshari, C. Ginting, L. Chiuman, Yuliani Mardiati Lubis","doi":"10.36656/jpfh.v2i1.195","DOIUrl":"https://doi.org/10.36656/jpfh.v2i1.195","url":null,"abstract":"This study aims to determine whether mangosteen rind extract (in the form of ethanol extract/EE) can be used as an anti-diarrhea drug after compared with other anti-diarrhea substances in three experimental groups. This research is an in vitro experimental study using adult male guinea pigs weighing 400-600 gr through the standard method of Magnus with the Latin square controlled experiment design. The study was conducted at the Pharmacology and Toxicology Laboratory of the Faculty of Pharmacy, University of North Sumatra. The results showed that the contraction of ileum in Ach with Atp + Ach compared the difference in contraction of ileum Ach with EE + Ach showed the difference in difference between the two contractions of the ileum was significant, the contraction of ileum in His with Dip + His compared indifference in contraction of ileum His with EE + His showed a difference indifference. the two ileal contractions are significant, the ileal contraction in the bar with Papa + Bar compared to the difference between the ileum bar contraction with EE + Bar shows no difference in the difference between the two ileum contractions. The conclusion is that the Mangosteen Skin Ethanol Extract works similarly to Papaverine Hydrochloride which is an antidiarrheal drug used to relax smooth muscles so that it can also make blood vessels dilate by relaxing smooth muscles in the walls of blood vessels.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79191454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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