Pub Date : 2022-12-20DOI: 10.53864/jifakfar.v3i1.155
Rosida Hari, Kukuh Judy Handojo
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis can infect anyone in the patient's environment. Someone with good body immunity conditions will avoid tuberculosis. Increased immunity for tuberculosis sufferers is very important. The active substances contained in plants such as flavonoids and essential oils are important components in supporting the body's immunity. One plant that contains flavonoids and essential oils is kencur (Kaemferia galanga L.). This study aims to prove the potential of kencur extract as an immunomodulator in model rat infected with Mycobacterium tuberculosis. This study was a laboratory experiment using the kencur extract (EK) and samples of rats as a model. The sample used was 30 animals which were divided into 6 groups. Group 1 was a healthy animal (Normal). Groups 2, 3, 4 and 5 were treatment groups consisting of sick animals given placebo treatment (control), rifampicin (R), EK (Kencur Extract) and CRK (Mixture of Rifampicin and Kencur). Group 6 was a normal group given EK then infected with Mycobacterium tuberculosis (NK). Modeling was done by infecting experimental animals using Mycobacterium tuberculosis. The infection was 30 days and the treatment was 21 days. The parameters in this study were leukocytes and Laju Endap Darah (LED). The results of the kencur extract phytochemical screening study showed the presence of flavonoids. The results of the treatment showed that differences in the number of Leukocytes and LEDs between the control group and the treatment (sig <0.05). These results indicate that kencur extract has the potential as an immunomodulator.
结核病是一种由结核分枝杆菌引起的传染病。结核病可以感染病人周围的任何人。身体免疫力好的人会避免患肺结核。提高结核病患者的免疫力非常重要。植物中含有的活性物质，如类黄酮和精油，是支持人体免疫力的重要成分。一种含有黄酮类化合物和精油的植物是kencur (Kaemferia galanga L.)。本研究旨在证明kencur提取物对结核分枝杆菌感染模型大鼠的免疫调节剂作用。本研究是以kencur提取物(EK)和大鼠标本为模型的室内实验。实验选用30只动物，分为6组。1组为健康动物(正常)。第2、3、4和5组为治疗组，由给予安慰剂(对照)、利福平(R)、Kencur提取物EK和CRK(利福平和Kencur混合物)的病鼠组成。第6组为正常组，给予EK后感染结核分枝杆菌(NK)。用结核分枝杆菌感染实验动物建立模型。感染30天，治疗21天。本研究的参数为白细胞和Laju Endap Darah (LED)。对莪术提取物进行了植物化学筛选，结果表明莪术提取物中含有黄酮类化合物。治疗结果显示，对照组与治疗组白细胞和发光二极管数量差异有统计学意义(p <0.05)。这些结果表明，kencur提取物具有作为免疫调节剂的潜力。
{"title":"POTENSI EKSTRAK KENCUR (Kaemferia galanga L.) SEBAGAI IMUNOMODULATOR PADA TIKUS MODEL YANG TERINFEKSI Mycobacterium tuberculosis","authors":"Rosida Hari, Kukuh Judy Handojo","doi":"10.53864/jifakfar.v3i1.155","DOIUrl":"https://doi.org/10.53864/jifakfar.v3i1.155","url":null,"abstract":"Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Tuberculosis can infect anyone in the patient's environment. Someone with good body immunity conditions will avoid tuberculosis. Increased immunity for tuberculosis sufferers is very important. The active substances contained in plants such as flavonoids and essential oils are important components in supporting the body's immunity. One plant that contains flavonoids and essential oils is kencur (Kaemferia galanga L.). This study aims to prove the potential of kencur extract as an immunomodulator in model rat infected with Mycobacterium tuberculosis. This study was a laboratory experiment using the kencur extract (EK) and samples of rats as a model. The sample used was 30 animals which were divided into 6 groups. Group 1 was a healthy animal (Normal). Groups 2, 3, 4 and 5 were treatment groups consisting of sick animals given placebo treatment (control), rifampicin (R), EK (Kencur Extract) and CRK (Mixture of Rifampicin and Kencur). Group 6 was a normal group given EK then infected with Mycobacterium tuberculosis (NK). Modeling was done by infecting experimental animals using Mycobacterium tuberculosis. The infection was 30 days and the treatment was 21 days. The parameters in this study were leukocytes and Laju Endap Darah (LED). The results of the kencur extract phytochemical screening study showed the presence of flavonoids. The results of the treatment showed that differences in the number of Leukocytes and LEDs between the control group and the treatment (sig <0.05). These results indicate that kencur extract has the potential as an immunomodulator.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81729841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.53864/jifakfar.v2i1.146
Y. A. Prasetya, K. Nisyak
Lactobacillus acidophillus dalam bentuk yoghurt mempunyai efek penurunan terhadap hiperkolesterolemia namun dapat mengalami stress akibat asam lambung. Teknik bioenkapsulasi mampu meningkatkan viabilitas dan perlindungan terhadap bakteri asam laktat tersebut. Penelitian ini bertujuan untuk mengetahui bahan bioenkapsulasi L. acidophillus dari Whey Protein Isolate (WPI), kasein, gum arab, dan amilum yang terbaik viabilitasnya terhadap asam lambung dan mengetahui dosis bioenkapsulasi yoghurt (single, double atau triple dose) yang efektif sebagai terapi antihiperkolesterolemia. Viabilitas bioenkapsulasi yoghurt terhadap asam lambung dilakukan secara in vitro dengan teknik Total Plate Count (TPC) kemudian diujikan aktivitas antihiperkolesterolemia secara in vivo terhadap tikus putih galur wistar. Hasil menunjukkan bahwa bahan dari amilum menunjukkan hasil yang terbaik dalam peningkatan viabilitas sebelum dan sesudah diberi perlakuan asam lambung yakni dari 3.0 x106 CFU/g menjadi 2.1 x 108 CFU/g. Dosis yang efektif sebagai antihiperkolesterolemia pada tikus putih wistar yakni single dose dengan nilai rataan kadar Low Density Lipoprotein (LDL) sebesar 15mg.dL-1.
{"title":"BIOENKAPSULASI YOGHURT Lactobacillus acidophillus SEBAGAI ANTIHIPERKOLESTROLEMIA","authors":"Y. A. Prasetya, K. Nisyak","doi":"10.53864/jifakfar.v2i1.146","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i1.146","url":null,"abstract":"Lactobacillus acidophillus dalam bentuk yoghurt mempunyai efek penurunan terhadap hiperkolesterolemia namun dapat mengalami stress akibat asam lambung. Teknik bioenkapsulasi mampu meningkatkan viabilitas dan perlindungan terhadap bakteri asam laktat tersebut. Penelitian ini bertujuan untuk mengetahui bahan bioenkapsulasi L. acidophillus dari Whey Protein Isolate (WPI), kasein, gum arab, dan amilum yang terbaik viabilitasnya terhadap asam lambung dan mengetahui dosis bioenkapsulasi yoghurt (single, double atau triple dose) yang efektif sebagai terapi antihiperkolesterolemia. Viabilitas bioenkapsulasi yoghurt terhadap asam lambung dilakukan secara in vitro dengan teknik Total Plate Count (TPC) kemudian diujikan aktivitas antihiperkolesterolemia secara in vivo terhadap tikus putih galur wistar. Hasil menunjukkan bahwa bahan dari amilum menunjukkan hasil yang terbaik dalam peningkatan viabilitas sebelum dan sesudah diberi perlakuan asam lambung yakni dari 3.0 x106 CFU/g menjadi 2.1 x 108 CFU/g. Dosis yang efektif sebagai antihiperkolesterolemia pada tikus putih wistar yakni single dose dengan nilai rataan kadar Low Density Lipoprotein (LDL) sebesar 15mg.dL-1.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90470611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.53864/jifakfar.v3i2.150
Dewi - Rashati, Icha Ayuning Suprayitno
Edamame seeds (glycine max (L) merr) is a soybean variety that is harvested while still young. Isoflavones present in soybeans such as deidzein, glycitein, and genistein have activity in inhibiting the tyrosinase enzyme to achieve skin lightening effects for skin whitening cosmetics. In this study the gel was formulated with HPMC (Hydroxypropyl methylcellulose) 2%, 3%, 5% as a gel forming agent. Evaluation includes organoleptic, homogeneity, pH, viscosity, and spreadability. The results of organoleptic evaluation of gel form in formula 1 fulfill the requirements, in formula 2 and 3 do not meet the requirements. The physical properties of the odor and color organoleptic formulas 1, 2, and 3 are eligible. in the homogeneity test of formulas 1, 2, and 3 are homogen. In the pH test formula 1,2,3 fulfills skin pH susceptibility pH 6. In the viscosity test of formula 1 250 dPa.S, Formula 2 500 dPa.S and formula 3 800 dPa.S.in the spread test of formula 1 it is 4.4cm, formula 2 is 3.8cm, and formula 3 is 3.7cm. From the results test of the Formula 1 (2% HPMC) meets all physical requirements of the gels.
毛豆种子(glycine max (L) merr)是一种大豆品种，在还年轻的时候就收获了。大豆中存在的异黄酮如去黄素、糖苷、染料木素等具有抑制酪氨酸酶的活性，从而达到美白化妆品的亮肤效果。在本研究中，以HPMC(羟丙基甲基纤维素)2%，3%，5%作为凝胶形成剂配制凝胶。评价包括感官、均匀性、pH值、粘度和铺展性。公式1中凝胶形态的感官评价结果满足要求，公式2和公式3不满足要求。气味和颜色感官公式1、2和3的物理性质是合格的。在同质性检验中，公式1、2、3是同质的。pH试验中公式1、2、3满足皮肤pH敏感性pH值6。在粘度试验中，公式1为250dpa。S，公式2500dpa。公式1的扩散试验为4.4cm，公式2为3.8cm，公式3为3.7cm。从试验结果来看，公式1 (2% HPMC)满足了凝胶的所有物理要求。
{"title":"PENGARUH VARIASI KONSENTRASI GELLING AGENT HPMC (Hidroxypropyl methylcellulose) TERHADAP SIFAT FISIK GEL EKSTRAK ETANOL BIJI EDAMAME (Glycine max)","authors":"Dewi - Rashati, Icha Ayuning Suprayitno","doi":"10.53864/jifakfar.v3i2.150","DOIUrl":"https://doi.org/10.53864/jifakfar.v3i2.150","url":null,"abstract":"Edamame seeds (glycine max (L) merr) is a soybean variety that is harvested while still young. Isoflavones present in soybeans such as deidzein, glycitein, and genistein have activity in inhibiting the tyrosinase enzyme to achieve skin lightening effects for skin whitening cosmetics. In this study the gel was formulated with HPMC (Hydroxypropyl methylcellulose) 2%, 3%, 5% as a gel forming agent. Evaluation includes organoleptic, homogeneity, pH, viscosity, and spreadability. The results of organoleptic evaluation of gel form in formula 1 fulfill the requirements, in formula 2 and 3 do not meet the requirements. The physical properties of the odor and color organoleptic formulas 1, 2, and 3 are eligible. in the homogeneity test of formulas 1, 2, and 3 are homogen. In the pH test formula 1,2,3 fulfills skin pH susceptibility pH 6. In the viscosity test of formula 1 250 dPa.S, Formula 2 500 dPa.S and formula 3 800 dPa.S.in the spread test of formula 1 it is 4.4cm, formula 2 is 3.8cm, and formula 3 is 3.7cm. From the results test of the Formula 1 (2% HPMC) meets all physical requirements of the gels.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84523186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.53864/jifakfar.v2i2.140
Holdin Eka Prilia, Rosida Hari
Water pumpkin (Lagenaria siceria) is a useful plant in Indonesian. People used water pumpkin flesh as a drug wound, especially as wound burning. This study was prove the activity of water pumpkin flesh extract as wound burning in male rats Wistar strain. The method in this research used experimental. This study used 25 male rats Wistar strain divided into 5 groups. The positive control group was given bioplacenton, the negative control group was given CMC-Na base gel, the other group was given water pumpkin gel extract at doses 2.5%, 5% and 7.5%. compount of water pumpkin extract are flavonoid and saponin. This compount have activity as a burn medicine in male rats wistar strain. At activity level 2.5% has activity 40,06%, at dose 5% has activity 49,75%, and at dose 7.5% has activity 60,11%. Water pumpkin gel extract at 2.5%, 5%, 7.5% dose had different activity with negative control group with CMC-Na gel base, but no significant difference (sig> 0,05) 25%, 50%, 75%.
{"title":"UJI AKTIVITAS EKSTRAK LABU AIR (Lagenaria siceria) TERHADAP LUKA BAKAR TIKUS JANTAN GALUR WISTAR","authors":"Holdin Eka Prilia, Rosida Hari","doi":"10.53864/jifakfar.v2i2.140","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i2.140","url":null,"abstract":"Water pumpkin (Lagenaria siceria) is a useful plant in Indonesian. People used water pumpkin flesh as a drug wound, especially as wound burning. This study was prove the activity of water pumpkin flesh extract as wound burning in male rats Wistar strain. The method in this research used experimental. This study used 25 male rats Wistar strain divided into 5 groups. The positive control group was given bioplacenton, the negative control group was given CMC-Na base gel, the other group was given water pumpkin gel extract at doses 2.5%, 5% and 7.5%. compount of water pumpkin extract are flavonoid and saponin. This compount have activity as a burn medicine in male rats wistar strain. At activity level 2.5% has activity 40,06%, at dose 5% has activity 49,75%, and at dose 7.5% has activity 60,11%. Water pumpkin gel extract at 2.5%, 5%, 7.5% dose had different activity with negative control group with CMC-Na gel base, but no significant difference (sig> 0,05) 25%, 50%, 75%.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82856702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.53864/jifakfar.v1i1.128
Hadi Barru Hakam Fajar Siddiq, Rosida Hari, Erika Fauziah Prabawati
Antioxidants are compounds that can inhibit oxidation reactions with the free radicals and molecules are highly reactive. According to the previous research, edamame (Glycin max (L)Merril) plant is one of the plants that contains isoflavon compound that serves as an antioxidant. This study aims to determine the antioxidant activity of edamame extracts. This study is an experimental study. Edamame beans extract obtained by remaceration during 24 hours using 96% ethanol. The concentration of edamame beans extract were make different concentration from 90 ppm, 121,3 ppm, 143 ppm, 173,1 ppm. The extract then added with 0,02 g of DPPH free radicals that have been disolved in 100 mL of 96% ethanol. Those solutions were measured at wavelength 516,5 nm by an UV-Vis spectrophotometer. Vitamin C used as positive control. The result of Antioxidant activity of edamame beans extract has IC50value of 177,2 ppm and Vitamin C as a control has a IC50value 0,18 ppm.It means that 177,2 ppm of edamame beans extract classified as low antioxidant.
抗氧化剂是一种能抑制自由基氧化反应的化合物，具有高活性。根据以往的研究，毛豆(Glycin max (L)Merril)植物是一种含有异黄酮化合物的植物，具有抗氧化剂的作用。本研究旨在测定毛豆提取物的抗氧化活性。这项研究是一项实验性研究。用96%的乙醇再发酵24小时得到的毛豆提取物。毛豆提取物的浓度分别为90 ppm、121 ppm、3 ppm、143 ppm、173 ppm、1 ppm。然后在提取液中加入0.02 g溶解于100 mL 96%乙醇中的DPPH自由基。用紫外-可见分光光度计在波长516,5 nm处测量这些溶液。维生素C作为阳性对照。毛豆提取物的抗氧化活性ic50值为177.2 ppm，维生素C作为对照的ic50值为0.18 ppm。也就是说，毛豆提取物中的177.02 ppm属于低抗氧化剂。
{"title":"UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BIJI EDAMAME (Glycin max (L) Merril) DENGAN METODE DPPH","authors":"Hadi Barru Hakam Fajar Siddiq, Rosida Hari, Erika Fauziah Prabawati","doi":"10.53864/jifakfar.v1i1.128","DOIUrl":"https://doi.org/10.53864/jifakfar.v1i1.128","url":null,"abstract":"Antioxidants are compounds that can inhibit oxidation reactions with the free radicals and molecules are highly reactive. According to the previous research, edamame (Glycin max (L)Merril) plant is one of the plants that contains isoflavon compound that serves as an antioxidant. This study aims to determine the antioxidant activity of edamame extracts. This study is an experimental study. Edamame beans extract obtained by remaceration during 24 hours using 96% ethanol. The concentration of edamame beans extract were make different concentration from 90 ppm, 121,3 ppm, 143 ppm, 173,1 ppm. The extract then added with 0,02 g of DPPH free radicals that have been disolved in 100 mL of 96% ethanol. Those solutions were measured at wavelength 516,5 nm by an UV-Vis spectrophotometer. Vitamin C used as positive control. The result of Antioxidant activity of edamame beans extract has IC50value of 177,2 ppm and Vitamin C as a control has a IC50value 0,18 ppm.It means that 177,2 ppm of edamame beans extract classified as low antioxidant.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"279 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73657691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.53864/jifakfar.v2i1.142
Dewi Rashati, Amirul Fauziah
This research is aims to determine the effect of variation concentration starch Zea mays (L) as disintegration agent in wet granulation to physical characteristics paracetamo. This research used eperimental method by one shot case study. Paracetamol as active ingredient, starch zea mays (L)as desintegrant agent, PVPK30 as binding agent, avicel as filler and Mg stearat as lubricants. The result of SPSS showed significant (p>0,05), that means no difference in the three formulation. The first test is weight uniformity show that from column A and B qualify weight requirement range, hardness test. Showed significant (p>0,05) that means nodifference in the three formulation. Friability test showed significant (p >0,05) the last is disintegration time test showed that significant (P>0,05) no difference in the three formulation. The research of physic characteristic of the tablet showed that hardness test and time test not qualif. Analysis SPSS showed (p>0,05) no difference in the three formulation and amilum had no effect on physical test of paracetamol tablet.
{"title":"PENGARUH VARIASI KONSENTRASI AMILUM Zea mays (L) SEBAGAI BAHAN PENGHANCUR SECARA GRANULASI BASAH TERHADAP SIFAT FISIK TABLET PARASETAMOL","authors":"Dewi Rashati, Amirul Fauziah","doi":"10.53864/jifakfar.v2i1.142","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i1.142","url":null,"abstract":"This research is aims to determine the effect of variation concentration starch Zea mays (L) as disintegration agent in wet granulation to physical characteristics paracetamo. This research used eperimental method by one shot case study. Paracetamol as active ingredient, starch zea mays (L)as desintegrant agent, PVPK30 as binding agent, avicel as filler and Mg stearat as lubricants. The result of SPSS showed significant (p>0,05), that means no difference in the three formulation. The first test is weight uniformity show that from column A and B qualify weight requirement range, hardness test. Showed significant (p>0,05) that means nodifference in the three formulation. Friability test showed significant (p >0,05) the last is disintegration time test showed that significant (P>0,05) no difference in the three formulation. The research of physic characteristic of the tablet showed that hardness test and time test not qualif. Analysis SPSS showed (p>0,05) no difference in the three formulation and amilum had no effect on physical test of paracetamol tablet.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77225190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.53864/jifakfar.v2i1.144
Kukuh Judy Handojo, Pradanu Satria Rakhmanta, Diyan Ajeng R.
PBF services in Lumajang region need to improve the quality of service, includingdelivery time often exceeds the time that had been promised, complaints regarding medication errors and difficulty getting accountability, the price has changed in a short time, and the service was not constant. The purpose of this study was to determine the level of drug store Lumajang region against drug distribution by PBF in tangible dimension (direct evidence), reliablity (reliability), responsivines (responsiveness),assurance (assurance), empathy (caring). Samples were selected in this research is all drug store in Lumajang totaling 30 pharmacies. The research design in this study is descriptive by using survey method.Based on the data collection process,there were only 30 drug store that are willing to be respondenden has qualified for data processing and it can be concluded that the level of satisfaction Pharmacy Lumajang region on tangible dimension (direct evidence) of 86.24%, expressed satisfaction,reliability dimension (reliability) by 80%, otherwise satisfactory, dimensions responsiviness (responsiveness) of 75.84%, expressed quite satisfactory, dimensions assurance (guarantee) amounting to 86.11%, declared satisfactory, the dimensions of empathy (caring) amounted to 86.94%, otherwise satisfactory. Based on the above data,it needs to be evaluated in five dimensions, from the evaluation it would appear that satisfaction level of drug store in Lumajang to PBF service (drug distribution)reach 83,02% and including the satisfactory category .
{"title":"TINGKAT KEPUASAN APOTEK DI WILAYAH LUMAJANG TERHADAP DISTRIBUSI OBAT OLEH PEDAGANG BESAR FARMASI","authors":"Kukuh Judy Handojo, Pradanu Satria Rakhmanta, Diyan Ajeng R.","doi":"10.53864/jifakfar.v2i1.144","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i1.144","url":null,"abstract":"PBF services in Lumajang region need to improve the quality of service, includingdelivery time often exceeds the time that had been promised, complaints regarding medication errors and difficulty getting accountability, the price has changed in a short time, and the service was not constant. The purpose of this study was to determine the level of drug store Lumajang region against drug distribution by PBF in tangible dimension (direct evidence), reliablity (reliability), responsivines (responsiveness),assurance (assurance), empathy (caring). Samples were selected in this research is all drug store in Lumajang totaling 30 pharmacies. The research design in this study is descriptive by using survey method.Based on the data collection process,there were only 30 drug store that are willing to be respondenden has qualified for data processing and it can be concluded that the level of satisfaction Pharmacy Lumajang region on tangible dimension (direct evidence) of 86.24%, expressed satisfaction,reliability dimension (reliability) by 80%, otherwise satisfactory, dimensions responsiviness (responsiveness) of 75.84%, expressed quite satisfactory, dimensions assurance (guarantee) amounting to 86.11%, declared satisfactory, the dimensions of empathy (caring) amounted to 86.94%, otherwise satisfactory. Based on the above data,it needs to be evaluated in five dimensions, from the evaluation it would appear that satisfaction level of drug store in Lumajang to PBF service (drug distribution)reach 83,02% and including the satisfactory category .","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81660852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.53864/jifakfar.v1i1.130
Dewi Rashati, Siti Mursidatur Rohmah
The purpose of this study was to determine the physical properties of theophylline floating tablet formulation with HPMC as matrix. Floating tablets of theophylline is manufactured by direct compression. Composition per tablet formulation consisting of theophylline 270 mg, HPMC, avicel, magnesium stearate, and sodium bicarbonate. The results of data showed average of tablet weight uniformity 501mg, tablet hardness 6,99 kg, tablet friability 0,593%, disintegration time of tablets 738 seconds, floating lag time (FLT) 584,3 seconds and floating duration time (FDT) more than 8 hours. Floating tablet formulation of theophylline resulted in a good physical test.
{"title":"UJI FISIK FORMULASI TABLET FLOATING TEOFILIN DENGAN MATRIK HPMC","authors":"Dewi Rashati, Siti Mursidatur Rohmah","doi":"10.53864/jifakfar.v1i1.130","DOIUrl":"https://doi.org/10.53864/jifakfar.v1i1.130","url":null,"abstract":"The purpose of this study was to determine the physical properties of theophylline floating tablet formulation with HPMC as matrix. Floating tablets of theophylline is manufactured by direct compression. Composition per tablet formulation consisting of theophylline 270 mg, HPMC, avicel, magnesium stearate, and sodium bicarbonate. The results of data showed average of tablet weight uniformity 501mg, tablet hardness 6,99 kg, tablet friability 0,593%, disintegration time of tablets 738 seconds, floating lag time (FLT) 584,3 seconds and floating duration time (FDT) more than 8 hours. Floating tablet formulation of theophylline resulted in a good physical test.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76818728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.53864/jifakfar.v2i2.139
S. Azizah
Limbah cangkang udang mengandung kitin yang tinggi yaitu sekitar 17-40%. Kitin tersebut dapat digunakan sebagai substat pertumbuhan bakteri kitinolitik yaitu S.marcescens KAHN 15.12. Bakteri tersebut akan mensekresikan enzim kitinase untuk mendegradasi kitin sebagai media pertumbuhannya hingga menghasilkan monomer N-asetil glukosamin (GlcNac). N-asetil glukosamin dapat dimanfaatkan sebagai bahan sediaan suplemen osteoartritis. Penelitian ini bertujuan untuk memproduksi GlcNac hasil hidrolisis kitin cangkang udang menggunakan kitinase Serratia marcescens KAHN.15.12. Hasil konfirmasi aktivitas kitinolitik menggunakan media selektif yaitu agar koloidal kitin 0,3% menunjukkan bahwa Serratia marcescens KAHN 15.12 memiliki index kitinolitik sebesar 2,3 yang ditunjukkan dengan adanya zona bening disekitar koloni. Hasil optimasi perbedaan konsentrasi media produksi menunjukkan bahwa tepung cangkang udang 2% menghasilkan kadar GlcNac tertinggi yaitu sebesar 376,35 μg/ml setelah diuji dengan metode kolorimetri menggunakan reagen shcales pada panjang gelombang 420nm. Berdasarkan hasil tersebut menunjukkan bahwa setiap hidrolisis 1 gram tepung cangkang udang yang mengandung 18,7% kitin akan menghasilkan sebesar 70,54 mg GlcNAc.
{"title":"OPTIMASI HIDROLISIS MEDIA PRODUKSI CANGKANG UDANG MENGGUNAKAN KITINASE SERRATIA MARCESCENS KAHN.15.12 TERHADAP KADAR N-ASETIL GLUKOSAMIN SEBAGAI BAHAN SEDIAAN","authors":"S. Azizah","doi":"10.53864/jifakfar.v2i2.139","DOIUrl":"https://doi.org/10.53864/jifakfar.v2i2.139","url":null,"abstract":"Limbah cangkang udang mengandung kitin yang tinggi yaitu sekitar 17-40%. Kitin tersebut dapat digunakan sebagai substat pertumbuhan bakteri kitinolitik yaitu S.marcescens KAHN 15.12. Bakteri tersebut akan mensekresikan enzim kitinase untuk mendegradasi kitin sebagai media pertumbuhannya hingga menghasilkan monomer N-asetil glukosamin (GlcNac). N-asetil glukosamin dapat dimanfaatkan sebagai bahan sediaan suplemen osteoartritis. Penelitian ini bertujuan untuk memproduksi GlcNac hasil hidrolisis kitin cangkang udang menggunakan kitinase Serratia marcescens KAHN.15.12. Hasil konfirmasi aktivitas kitinolitik menggunakan media selektif yaitu agar koloidal kitin 0,3% menunjukkan bahwa Serratia marcescens KAHN 15.12 memiliki index kitinolitik sebesar 2,3 yang ditunjukkan dengan adanya zona bening disekitar koloni. Hasil optimasi perbedaan konsentrasi media produksi menunjukkan bahwa tepung cangkang udang 2% menghasilkan kadar GlcNac tertinggi yaitu sebesar 376,35 μg/ml setelah diuji dengan metode kolorimetri menggunakan reagen shcales pada panjang gelombang 420nm. Berdasarkan hasil tersebut menunjukkan bahwa setiap hidrolisis 1 gram tepung cangkang udang yang mengandung 18,7% kitin akan menghasilkan sebesar 70,54 mg GlcNAc.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81118595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-20DOI: 10.53864/jifakfar.v1i1.131
Mikhania C.E., Dewi Rashati, Dadang Putra Mardigantara
The aim of this study was to compare physical properties ciprofloxacin 500 mg coated tablet generic and trademark brand. The test include weight uniformity, tablet hardness, tablet friability, and disintegration time test. Descriptive experimental design (the one-shot case study) was used as study design. Samples were taken from three generic brands and three trademarks brand ciprofloxacin 500 mg coated tablets. Samples were produced by different factories and taken by simple random sampling method. The results showed that ciprofloxacin 500 mg coated tablets generic and trademark brand are comparable unless hardness of tablet.
{"title":"PERBANDINGAN SIFAT FISIK TABLET SALUT CIPROFLOXACIN 500 MG MEREK GENERIK DAN MEREK DAGANG","authors":"Mikhania C.E., Dewi Rashati, Dadang Putra Mardigantara","doi":"10.53864/jifakfar.v1i1.131","DOIUrl":"https://doi.org/10.53864/jifakfar.v1i1.131","url":null,"abstract":"The aim of this study was to compare physical properties ciprofloxacin 500 mg coated tablet generic and trademark brand. The test include weight uniformity, tablet hardness, tablet friability, and disintegration time test. Descriptive experimental design (the one-shot case study) was used as study design. Samples were taken from three generic brands and three trademarks brand ciprofloxacin 500 mg coated tablets. Samples were produced by different factories and taken by simple random sampling method. The results showed that ciprofloxacin 500 mg coated tablets generic and trademark brand are comparable unless hardness of tablet.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81911717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：