Pub Date : 2022-02-16DOI: 10.53864/jifakfar.v4i2.74
Dewi - Rashati
Gummy candies paracetamol is chew candy containing the active subtance paracetamol with sweetener of sorbitol and cassava liquid sugar. The purpose of this study was to determine the effect of variations in the concentration of sorbitol and cassava liquid sugar as sweeteners on the physical properties of gummy candies paracetamol. Formulation of paracetamol gummy candies using diference concentration of sorbitol (20%, 15%, 10%) and cassava liquid sugar (40%, 45%, 50%).was used as the method pre-experimental design research method with one-shot case study design. Testing the physical properties of the preparations that have become chewing gum includes organoleptic tests, weight uniformity tests, pH tests and then the results are compared with the requirements in the literature. The results of the research on the physical properties of paracetamol gummy candy concluded that variations in the concentration of sorbitol sweetener and cassava liquid sugar had an effect on the uniformity of weight. Variations in the concentration of sorbitol sweetener and cassava liquid sugar did not affect the physical organoleptic properties of aroma, color, taste, texture, and physical properties of pH.Keywords : paracetamol, gummy candies, sorbitol, cassava liquid sugar
{"title":"THE EFFECT OF VARIATIONS IN THE CONCENTRATION SORBITOL AND CASSAVA LIQUID SUGAR (Manihot esculenta Crantz) OF SWEETENER ON THE PHYSICAL PROPERTIES OF GUMMY CANDIES PARACETAMOL","authors":"Dewi - Rashati","doi":"10.53864/jifakfar.v4i2.74","DOIUrl":"https://doi.org/10.53864/jifakfar.v4i2.74","url":null,"abstract":"Gummy candies paracetamol is chew candy containing the active subtance paracetamol with sweetener of sorbitol and cassava liquid sugar. The purpose of this study was to determine the effect of variations in the concentration of sorbitol and cassava liquid sugar as sweeteners on the physical properties of gummy candies paracetamol. Formulation of paracetamol gummy candies using diference concentration of sorbitol (20%, 15%, 10%) and cassava liquid sugar (40%, 45%, 50%).was used as the method pre-experimental design research method with one-shot case study design. Testing the physical properties of the preparations that have become chewing gum includes organoleptic tests, weight uniformity tests, pH tests and then the results are compared with the requirements in the literature. The results of the research on the physical properties of paracetamol gummy candy concluded that variations in the concentration of sorbitol sweetener and cassava liquid sugar had an effect on the uniformity of weight. Variations in the concentration of sorbitol sweetener and cassava liquid sugar did not affect the physical organoleptic properties of aroma, color, taste, texture, and physical properties of pH.Keywords : paracetamol, gummy candies, sorbitol, cassava liquid sugar","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88413950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-16DOI: 10.53864/jifakfar.v4i2.75
Asa Falahi
Emulgel is a semi-solid preparation, in the form of an emulsion where the viscosity is increased by the addition of the gelling agent. Emulgel can be used for formulations of active substances that are difficult to dissolve in water. Meloxicam is a first-line treatment to treat rheumatoid arthritis and osteoarthritis. The aim of the study was determine the stability of the physical properties of emulgel meloxicam with the Freeze thaw test. The research design used was quasi experimental. In this study there were 2 storage temperatures, the freeze temperature of 4-8oC and thaw temperature of 40-48oC. The treatment was carried out in 3 cycles for 6 days. Physical stability test of organoleptic (color, odor, and dosage form) showed no difference during storage. Physical stability test of homogenity also showed no difference during storage. Physical stability of the emulsion type showed that there was no phase separation in the emulsifying gel during storage. Significance of pH is 0,083 (p 0,05), viscosity is 0,083 (p0,05), and spreadabilityis 0,102 (p 0,05) can be interpreted that the physical stability of pH, viscosity and dispersion power has no significant difference. From all research data, it can be seen that the meloxicam emulgel preparation did notchanges in physical stability after passing 3 cycles.
{"title":"STABILITAS FISIK EMULGEL MELOKSIKAM MENGGUNAKAN METODE FREEZE THAW","authors":"Asa Falahi","doi":"10.53864/jifakfar.v4i2.75","DOIUrl":"https://doi.org/10.53864/jifakfar.v4i2.75","url":null,"abstract":"Emulgel is a semi-solid preparation, in the form of an emulsion where the viscosity is increased by the addition of the gelling agent. Emulgel can be used for formulations of active substances that are difficult to dissolve in water. Meloxicam is a first-line treatment to treat rheumatoid arthritis and osteoarthritis. The aim of the study was determine the stability of the physical properties of emulgel meloxicam with the Freeze thaw test. The research design used was quasi experimental. In this study there were 2 storage temperatures, the freeze temperature of 4-8oC and thaw temperature of 40-48oC. The treatment was carried out in 3 cycles for 6 days. Physical stability test of organoleptic (color, odor, and dosage form) showed no difference during storage. Physical stability test of homogenity also showed no difference during storage. Physical stability of the emulsion type showed that there was no phase separation in the emulsifying gel during storage. Significance of pH is 0,083 (p 0,05), viscosity is 0,083 (p0,05), and spreadabilityis 0,102 (p 0,05) can be interpreted that the physical stability of pH, viscosity and dispersion power has no significant difference. From all research data, it can be seen that the meloxicam emulgel preparation did notchanges in physical stability after passing 3 cycles.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86256706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-16DOI: 10.53864/jifakfar.v4i2.64
Churori Rorik Cahyono
ABSTRACTBackground research: Antibiotics are the most widely used drug class in the world due to the high incidence of bacterial infections. The high use of antibiotics but not balanced with the rational use of antibiotics can have a negative impact, one of which is resistance. Objective: This study was conducted to examine the prescribing pattern and rationale for the use of antibiotics in the Kalisat Jember Hospital. Research method: This study used a descriptive design, data collection was carried out retrospectively which was taken from October to December 2020 at the surgical clinic at the Kalisat Jember area hospital. Result and coclusion: Based on the calculation results, the number of samples used in this study were 263 prescription sheets with antibiotics. From the results of the study, it was found that the most prescribed pattern of antibiotic prescribing was cefixime as many as 165 prescriptions (62.74%) and the most antibiotic preparations prescribed in tablet form were 253 prescriptions (96.20%). From the results of the study, it was also found that the rationality of the use of antibiotics, namely the accuracy of the dose of 100%, the accuracy of the frequency of 99.24% and the accuracy of the duration of 100%.Keywords: Antibiotic, rational, prescription
{"title":"The Prescription Pattern And Rationality Of Antibiotics Usage In General Surgery Polyclinic Patient At RSD Kalisat In October - December 2020","authors":"Churori Rorik Cahyono","doi":"10.53864/jifakfar.v4i2.64","DOIUrl":"https://doi.org/10.53864/jifakfar.v4i2.64","url":null,"abstract":"ABSTRACTBackground research: Antibiotics are the most widely used drug class in the world due to the high incidence of bacterial infections. The high use of antibiotics but not balanced with the rational use of antibiotics can have a negative impact, one of which is resistance. Objective: This study was conducted to examine the prescribing pattern and rationale for the use of antibiotics in the Kalisat Jember Hospital. Research method: This study used a descriptive design, data collection was carried out retrospectively which was taken from October to December 2020 at the surgical clinic at the Kalisat Jember area hospital. Result and coclusion: Based on the calculation results, the number of samples used in this study were 263 prescription sheets with antibiotics. From the results of the study, it was found that the most prescribed pattern of antibiotic prescribing was cefixime as many as 165 prescriptions (62.74%) and the most antibiotic preparations prescribed in tablet form were 253 prescriptions (96.20%). From the results of the study, it was also found that the rationality of the use of antibiotics, namely the accuracy of the dose of 100%, the accuracy of the frequency of 99.24% and the accuracy of the duration of 100%.Keywords: Antibiotic, rational, prescription","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84146200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-16DOI: 10.53864/jifakfar.v4i2.57
Mikhania Christiningtyas Eryani
Mouthwash is an aqueous solution used as a cleanser to improve oral health, aesthetics, and breath freshness. The purpose of this study was to determine the effect of variation concentration of glycerin in beluntas leaf extract (Pluchea indica L.) on the physical properties of mouthwash. Extraction was using maceration method with 5000 ml of 96% ethanol as a solvent. Beluntas leaf extract mouthwash was made in 3 formulas with different glycerin concentration which were 10% (F1), 15% (F2) and 20% (F3). Evaluation includes organoleptic, pH and viscosity tests. The organoleptic test of the mouthwash on the three formulations was brown in color, tasted slightly sweet and had a distinctive minty smell. pH of three formulas were 6.16 - 6.20. Data processing using One Way Anova showed that there was no effect of glycerin variations concentration to pH of mouthwash but there was an effect of glycerin variations concentration to the viscosity of mouthwash.
{"title":"PENGARUH VARIASI KONSENTRASI GLISERIN TERHADAP SIFAT FISIK OBAT KUMUR EKSTRAK DAUN BELUNTAS (Pluchea indica L.)","authors":"Mikhania Christiningtyas Eryani","doi":"10.53864/jifakfar.v4i2.57","DOIUrl":"https://doi.org/10.53864/jifakfar.v4i2.57","url":null,"abstract":"Mouthwash is an aqueous solution used as a cleanser to improve oral health, aesthetics, and breath freshness. The purpose of this study was to determine the effect of variation concentration of glycerin in beluntas leaf extract (Pluchea indica L.) on the physical properties of mouthwash. Extraction was using maceration method with 5000 ml of 96% ethanol as a solvent. Beluntas leaf extract mouthwash was made in 3 formulas with different glycerin concentration which were 10% (F1), 15% (F2) and 20% (F3). Evaluation includes organoleptic, pH and viscosity tests. The organoleptic test of the mouthwash on the three formulations was brown in color, tasted slightly sweet and had a distinctive minty smell. pH of three formulas were 6.16 - 6.20. Data processing using One Way Anova showed that there was no effect of glycerin variations concentration to pH of mouthwash but there was an effect of glycerin variations concentration to the viscosity of mouthwash.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86056933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-12DOI: 10.53864/jifakfar.v4i1.49
Asa Falahi, Dewi - Rashati
Glibenclamide is a sulfonylurea class of antidiabetic drugs that works by stimulating insulin secretion in the pancreas so that it is effective only when the β-cells of the pancreas can still produce. The glibenclamide dosage form that is on the market is a conventional oral tablet which has various disadvantages in terms of pharmacokinetics. Based on this, it is necessary to develop a more effective drug delivery system for glibenclamide in order to avoid first-pass metabolism so as to increase the bioavailability of glibenclamide, namely by making mucoadhesive buccal tablets. This glibenclamide mucoadhesive buccal tablet is formulated using a variety of mucoadhesive polymers, namely CMC Na and oleic acid as enhancers. The manufacture of four mucoadhesive buccal tablet formulas used the direct compression method. The results of the weight uniformity test showed that they did not meet the NP requirements specified, all formulas had an NP of more than 15. The tablet hardness test also showed results that did not meet the test requirements. However, the results of the physical properties of the brittleness, pH and swelling index showed the results that met the test requirements. In this research, the optimum variation of CMC Na polymer and oleic acid as enhancers to physical properties (hardness, brittleness, pH, swelling ability) and the release of glibenclamide mucoadhesive tablets were CMC Na of 37.5 mg and oleic acid of 3.5. ml.
{"title":"OPTIMASI FORMULA TABLET BUKAL MUKOADHESIVE GLIBENKLAMID MENGGUNAKAN MATRIKS CMC NA SERTA ASAM OLEAT SEBAGAI ENHANCHER","authors":"Asa Falahi, Dewi - Rashati","doi":"10.53864/jifakfar.v4i1.49","DOIUrl":"https://doi.org/10.53864/jifakfar.v4i1.49","url":null,"abstract":"Glibenclamide is a sulfonylurea class of antidiabetic drugs that works by stimulating insulin secretion in the pancreas so that it is effective only when the β-cells of the pancreas can still produce. The glibenclamide dosage form that is on the market is a conventional oral tablet which has various disadvantages in terms of pharmacokinetics. Based on this, it is necessary to develop a more effective drug delivery system for glibenclamide in order to avoid first-pass metabolism so as to increase the bioavailability of glibenclamide, namely by making mucoadhesive buccal tablets. This glibenclamide mucoadhesive buccal tablet is formulated using a variety of mucoadhesive polymers, namely CMC Na and oleic acid as enhancers. The manufacture of four mucoadhesive buccal tablet formulas used the direct compression method. The results of the weight uniformity test showed that they did not meet the NP requirements specified, all formulas had an NP of more than 15. The tablet hardness test also showed results that did not meet the test requirements. However, the results of the physical properties of the brittleness, pH and swelling index showed the results that met the test requirements. In this research, the optimum variation of CMC Na polymer and oleic acid as enhancers to physical properties (hardness, brittleness, pH, swelling ability) and the release of glibenclamide mucoadhesive tablets were CMC Na of 37.5 mg and oleic acid of 3.5. ml.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80862276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-12DOI: 10.53864/jifakfar.v4i1.50
S. Azizah
The objective of this research was to known antibacterial activity of 4 endhophytic Streptomyces namely Streptomyces griseorubiginosus, Streptomyces vellosus, Streptomyces diastaticus and Streptomyces griseoruber against Staphylococcus aureus and Eschericia coli and measure the biggest antibacterial activity which is indicate by clear zone diameter. Antibacterial activity by using agar plug diffusion method showed that Streptomyces vellosus has capable to inhibits growth of Staphylococcus aureus but not with Eschericia coli and Streptomyces diastaticus has capable to inhibits growth of Eschericia coli but not with Staphylococcus aureus. The clear zone of Streptomyces vellosus and Streptomyces diastaticus are 5,18 mm and 7 mm respectively. Streptomyces griseoruber and Streptomyces griseorubiginosus can’t grow during isolation. Keyword: Streptomyces vellosus, Streptomyces diastaticus, agar plug diffusion method
{"title":"ANTIBACTERIAL ACTIVITY Streptomyces spp. ENDHOPHYTIC TO Staphylococcus aureus AND Eschericia coli","authors":"S. Azizah","doi":"10.53864/jifakfar.v4i1.50","DOIUrl":"https://doi.org/10.53864/jifakfar.v4i1.50","url":null,"abstract":"The objective of this research was to known antibacterial activity of 4 endhophytic Streptomyces namely Streptomyces griseorubiginosus, Streptomyces vellosus, Streptomyces diastaticus and Streptomyces griseoruber against Staphylococcus aureus and Eschericia coli and measure the biggest antibacterial activity which is indicate by clear zone diameter. Antibacterial activity by using agar plug diffusion method showed that Streptomyces vellosus has capable to inhibits growth of Staphylococcus aureus but not with Eschericia coli and Streptomyces diastaticus has capable to inhibits growth of Eschericia coli but not with Staphylococcus aureus. The clear zone of Streptomyces vellosus and Streptomyces diastaticus are 5,18 mm and 7 mm respectively. Streptomyces griseoruber and Streptomyces griseorubiginosus can’t grow during isolation. Keyword: Streptomyces vellosus, Streptomyces diastaticus, agar plug diffusion method","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89366908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fever is a condition often found in toddlers. Fever is a condition when the body temperature is above normal temperature (36-37ºC). The general objective of the study was to describe the level of knowledge of mothers in handling fever in children under five years old in Suci village, Panti Jember district. The research used a descriptive design. Samples were taken by random samplingand obtained 81 mothers who have toddlers. This research instrument uses a questionnaire. The results showed that the level of mother's knowledge in handling fever in toddlers in the realm of know was 86%, in the realm of understand was 76%, and in the realm of application was 75%. It can be concluded that the level of mother's knowledge in handling fever in toddlers in Suci village, Panti Jember sub-district in the realm of know and in the realm of understand was a good criterion, and in the realm of application was a fairly good criterion.Keywords: toddlers, fever, mother's knowledge level
{"title":"THE LEVEL OF MOTHER'S KNOWLEDGE IN HANDLING FEVER IN CHILDREN IN SUCI VILLAGE, PANTI JEMBER SUB-DISTRICT","authors":"Amaliyah Nurul Hidayah, Alfira Septia Wahyuni, Diyan Ajeng Rossetyowati","doi":"10.53864/jifakfar.v4i1.43","DOIUrl":"https://doi.org/10.53864/jifakfar.v4i1.43","url":null,"abstract":"Fever is a condition often found in toddlers. Fever is a condition when the body temperature is above normal temperature (36-37ºC). The general objective of the study was to describe the level of knowledge of mothers in handling fever in children under five years old in Suci village, Panti Jember district. The research used a descriptive design. Samples were taken by random samplingand obtained 81 mothers who have toddlers. This research instrument uses a questionnaire. The results showed that the level of mother's knowledge in handling fever in toddlers in the realm of know was 86%, in the realm of understand was 76%, and in the realm of application was 75%. It can be concluded that the level of mother's knowledge in handling fever in toddlers in Suci village, Panti Jember sub-district in the realm of know and in the realm of understand was a good criterion, and in the realm of application was a fairly good criterion.Keywords: toddlers, fever, mother's knowledge level","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89727980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-12DOI: 10.53864/jifakfar.v4i1.44
Rosida Hari
Penyakit kardiovaskular merupakan penyebab kematian utama didunia dan jumlah kasus penyakit ini telah mengalami peningkatan selama satu decade terakhir. Salah satu penyebabnya adalah hipertrigliserida. Hipertrigliseridemia atau tingginya kadar trigliserida darah merupakan salah satu kelainan fraksi lipid yang berhubungan dengan peningkatan resiko penyakit kardiovaskular Penurunan kadar trigliserida dalam darah dapat dilakukan dengan terapi Gemfibrozil. Gemfibrozil adalah regulator lipid plasma yang dapat menurunkan kadar kolesterol total, kolesterol LDL, kolesterol VLDL dan trigliserida serta meningkatkan kolesterol HDL. Penelitian ini bertujuan untuk mengetahui efektivitas gemfibrozil 300 mg terhadap kadar trigliserida pada pasien hipertrigliseridemia di Poliklinik Pratama Negeri Jember (periode Mei-Juli 2020). Jenis penelitian yang digunakan adalah deskriptif observasional dengan metode pendekatan cross sectional. Teknik pengambilan sampel menggunakan total sampling. Pengukuran kadar trigliserida dilakukan pada 60 pasien sebelum dan sesudah menggunakan gemfibrozil 300 mg. Hasil penelitian menunjukkan, persentase penurunan setelah menggunakan gemfibrozil 300 mg terendah sebesar 10,27 ± 8,64% dan tertinggi sebesar 40,40 ± 12,38%. Rata-rata kadar trigliserida sebelum penggunaan gemfibrozil 300 mg sebesar 295,35 ± 35 mg / dl dan rata-rata kadar trigliserida setelah penggunaan gemfibrozil 300 mg adalah 196,75 ± 49,59 mg / dl.
{"title":"PROFIL KADAR TRIGLISERIDA PASIEN HIPERTRIGLISERIDEMIA SETELAH PENGGUNAAN GEMFIBROZIL 300 mg DI POLIKLINIK PRATAMA POLITEKNIK NEGERI JEMBER","authors":"Rosida Hari","doi":"10.53864/jifakfar.v4i1.44","DOIUrl":"https://doi.org/10.53864/jifakfar.v4i1.44","url":null,"abstract":"Penyakit kardiovaskular merupakan penyebab kematian utama didunia dan jumlah kasus penyakit ini telah mengalami peningkatan selama satu decade terakhir. Salah satu penyebabnya adalah hipertrigliserida. Hipertrigliseridemia atau tingginya kadar trigliserida darah merupakan salah satu kelainan fraksi lipid yang berhubungan dengan peningkatan resiko penyakit kardiovaskular Penurunan kadar trigliserida dalam darah dapat dilakukan dengan terapi Gemfibrozil. Gemfibrozil adalah regulator lipid plasma yang dapat menurunkan kadar kolesterol total, kolesterol LDL, kolesterol VLDL dan trigliserida serta meningkatkan kolesterol HDL. Penelitian ini bertujuan untuk mengetahui efektivitas gemfibrozil 300 mg terhadap kadar trigliserida pada pasien hipertrigliseridemia di Poliklinik Pratama Negeri Jember (periode Mei-Juli 2020). Jenis penelitian yang digunakan adalah deskriptif observasional dengan metode pendekatan cross sectional. Teknik pengambilan sampel menggunakan total sampling. Pengukuran kadar trigliserida dilakukan pada 60 pasien sebelum dan sesudah menggunakan gemfibrozil 300 mg. Hasil penelitian menunjukkan, persentase penurunan setelah menggunakan gemfibrozil 300 mg terendah sebesar 10,27 ± 8,64% dan tertinggi sebesar 40,40 ± 12,38%. Rata-rata kadar trigliserida sebelum penggunaan gemfibrozil 300 mg sebesar 295,35 ± 35 mg / dl dan rata-rata kadar trigliserida setelah penggunaan gemfibrozil 300 mg adalah 196,75 ± 49,59 mg / dl.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78439003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-12DOI: 10.53864/jifakfar.v4i1.46
Hadi Barru Hakam Fajar Siddiq
The synthesis of amoxicillin derivatives was carried out by reaction of amoxicillin with p-aminophenol which was catalyzed by MgF2. The aims of this research was to characterize amoxicillin derivatives. The compounds have been characterized by physical and chemical tests including organoleptic test, melting point test, pH test, Rf value test and maximum wavelength test. The results showed that the compounds having physical characteristics including organoleptic was brown powder and bitter taste with 238°C melting point. The chemical characteristic showed that Rf value was about 0.6, a pH was 6,1 and a maximum wavelength was 311 nm.
{"title":"PENGGUNAAN KATALIS MgF2 DALAM SINTESIS SENYAWA TURUNAN AMOKSISILIN","authors":"Hadi Barru Hakam Fajar Siddiq","doi":"10.53864/jifakfar.v4i1.46","DOIUrl":"https://doi.org/10.53864/jifakfar.v4i1.46","url":null,"abstract":"The synthesis of amoxicillin derivatives was carried out by reaction of amoxicillin with p-aminophenol which was catalyzed by MgF2. The aims of this research was to characterize amoxicillin derivatives. The compounds have been characterized by physical and chemical tests including organoleptic test, melting point test, pH test, Rf value test and maximum wavelength test. The results showed that the compounds having physical characteristics including organoleptic was brown powder and bitter taste with 238°C melting point. The chemical characteristic showed that Rf value was about 0.6, a pH was 6,1 and a maximum wavelength was 311 nm.","PeriodicalId":17737,"journal":{"name":"JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76758665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-12DOI: 10.53864/jifakfar.v4i1.51
Kukuh Handojo
The "PANAH" programme is one of the innovative Pharmacy Installation services at RSUD Genteng. PANAH is an abbreviation of Pangkas Antrian Ambil Obat Harian. This program is a new program and there has never been a measurement of the level of satisfaction so that it is necessary to measure the level of satisfaction.This study aims to determine the level of satisfaction of patients served by the “PANAH” program at RSUD Genteng based on five dimensions of service quality, namely tangible, reliability, responsiveness, empathy, assurance.The type of research used is descriptive quantitative research with cross sectional design and the sample technique used is total sampling. Samples taken were 72 patients. Technique of answering data using a questionnaire.Based on the results of the study obtained as follows. On the dimensions of physical evidence (tangible) 43 respondents were satisfied (59,72%), 29 respondents were quite satisfied (40,28%). On the credibility dimension (reliability) 45 respondents were satisfied (62,5%), 27 respondents were quite satisfied (37,5%). On the dimension of responsiveness (responsiveness) 45 respondents were satisfied (62,5%), 27 respondents were quite satisfied (37,5%). On the dimension of empathy (emphaty) 42 respondents were satisfied (58,33%), 30 respondents were quite satisfied (41,67%). On the assurance dimension 41 respondents were satisfied (56,94%), 31 respondents were quite satisfied (43,06%). In the response of fifth dimension, namely tangible, reliability, responsiveness, empathy, assurance 52 respondents were satisfied (72,22%), 20 respondents were quite satisfied (27,78%), there were no respondents who were less satisfied and dissatisfied.
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