A. Rahimi, H. Samimagham, Ladan Hajiabdolrrasouli, M. Hassani Azad, Ali Salimi Asl, Fatemeh Khajavi Mayvan, E. Boushehri, M. Arabi, Sepideh Pazhoohesh, Mitra Kazemi Jahromi
Background: Today, various drugs have been investigated as the primary or complementary treatment for coronavirus disease 2019 (COVID-19). N-acetylcysteine (NAC) has been used as a mucolytic in pulmonary diseases. This drug apparently contributes to the retrieval of the intracellular antioxidant system. Objectives: This study aimed to determine the efficacy of NAC in severe COVID-19 patients admitted to the intensive care unit (ICU). Methods: This single-blinded randomized controlled phase III clinical trial included 40 patients with confirmed COVID-19 (based on polymerase chain reaction) admitted to the Shahid Mohammadi Hospital’s ICU, Bandar Abbas, Iran, in 2020. All cases had severe COVID-19. They were allocated randomly to two equal groups. Patients in the control group received standard drug therapy based on the treatment protocol of the national COVID-19 committee, while those in the NAC group received a single dose of intravenous NAC (300 mg/kg) upon admission to the ICU in addition to standard drug treatment. Clinical status and laboratory tests were done on admission to the ICU and then 14 days later or at discharge without knowing the patient grouping. Results: The two groups were comparable regarding age, gender, and other baseline laboratory and clinical parameters. At the final evaluation, respiratory rate (21.25 ± 4.67 vs. 27.37 ± 6.99 /min) and D-dimer (186.37 ± 410.23 vs. 1339.04 ± 2183.87 ng/mL) were significantly lower in the NAC group (P = 0.004 and P = 0.030, respectively). Also, a lower percentage of patients in the NAC group had lactate dehydrogenase (LDH) ≤ 245 U/L (0% vs. 25%, P = 0.047). Although the length of ward and ICU stay was shorter in the NAC group than in controls, the difference was statistically insignificant (P = 0.598 and P = 0.629, respectively). Mortality, on the other hand, was 75% in the control group and 50% in the NAC group, with no statistically significant difference (P = 0.102). Concerning the change in the study parameters, only the decrease in diastolic blood pressure (DBP) was significantly higher with NAC (P = 0.042). The intubation and mechanical ventilation rates were higher, while oxygen with mask and nasal oxygen rates were lower with NAC, but the difference was statistically insignificant. Conclusions: Based on the current research, NAC is related to a significant decrease in RR, D-dimer, and DBP in severe COVID-19. Also, LDH was significantly lower in the NAC group than in the controls. More research with larger sample sizes is needed to validate the current study results.
背景:目前，已经研究了各种药物作为2019冠状病毒病(COVID-19)的主要或补充治疗。n -乙酰半胱氨酸(NAC)已被用作肺部疾病的黏液溶解剂。这种药物显然有助于细胞内抗氧化系统的恢复。目的:本研究旨在确定NAC在重症监护病房(ICU)重症COVID-19患者中的疗效。方法:该单盲随机对照III期临床试验纳入了2020年在伊朗阿巴斯港Shahid Mohammadi医院ICU收治的40例确诊COVID-19患者(基于聚合酶链反应)。所有病例均为重症COVID-19。他们被随机分为两组。对照组患者按照国家新冠肺炎防治委员会治疗方案进行标准药物治疗，NAC组患者在标准药物治疗的基础上，于入住ICU时给予单剂量NAC (300 mg/kg)静脉注射。在不知道患者分组的情况下，于入院时和14天后或出院时分别进行临床状况和实验室检查。结果:两组在年龄、性别和其他基线实验室和临床参数方面具有可比性。最终评估时，NAC组呼吸频率(21.25±4.67 vs. 27.37±6.99 /min)和d -二聚体(186.37±410.23 vs. 1339.04±2183.87 ng/mL)均显著降低(P = 0.004和P = 0.030)。NAC组乳酸脱氢酶(LDH)≤245 U/L的患者比例较低(0% vs. 25%， P = 0.047)。NAC组病区时间和ICU住院时间虽短于对照组，但差异无统计学意义(P = 0.598、P = 0.629)。NAC组死亡率为50%，对照组为75%，差异无统计学意义(P = 0.102)。在研究参数的变化方面，NAC组只有舒张压(DBP)下降明显高于NAC组(P = 0.042)。NAC组插管和机械通气率较高，面罩供氧率和鼻供氧率较低，但差异无统计学意义。结论:根据目前的研究，NAC与重症COVID-19患者RR、d -二聚体和DBP的显著降低有关。NAC组的LDH也明显低于对照组。需要更多样本量更大的研究来验证目前的研究结果。
{"title":"Efficacy of N-acetyl Cysteine in Severe COVID-19 Patients: A Randomized Controlled Phase III Clinical Trial","authors":"A. Rahimi, H. Samimagham, Ladan Hajiabdolrrasouli, M. Hassani Azad, Ali Salimi Asl, Fatemeh Khajavi Mayvan, E. Boushehri, M. Arabi, Sepideh Pazhoohesh, Mitra Kazemi Jahromi","doi":"10.5812/jjnpp-129817","DOIUrl":"https://doi.org/10.5812/jjnpp-129817","url":null,"abstract":"Background: Today, various drugs have been investigated as the primary or complementary treatment for coronavirus disease 2019 (COVID-19). N-acetylcysteine (NAC) has been used as a mucolytic in pulmonary diseases. This drug apparently contributes to the retrieval of the intracellular antioxidant system. Objectives: This study aimed to determine the efficacy of NAC in severe COVID-19 patients admitted to the intensive care unit (ICU). Methods: This single-blinded randomized controlled phase III clinical trial included 40 patients with confirmed COVID-19 (based on polymerase chain reaction) admitted to the Shahid Mohammadi Hospital’s ICU, Bandar Abbas, Iran, in 2020. All cases had severe COVID-19. They were allocated randomly to two equal groups. Patients in the control group received standard drug therapy based on the treatment protocol of the national COVID-19 committee, while those in the NAC group received a single dose of intravenous NAC (300 mg/kg) upon admission to the ICU in addition to standard drug treatment. Clinical status and laboratory tests were done on admission to the ICU and then 14 days later or at discharge without knowing the patient grouping. Results: The two groups were comparable regarding age, gender, and other baseline laboratory and clinical parameters. At the final evaluation, respiratory rate (21.25 ± 4.67 vs. 27.37 ± 6.99 /min) and D-dimer (186.37 ± 410.23 vs. 1339.04 ± 2183.87 ng/mL) were significantly lower in the NAC group (P = 0.004 and P = 0.030, respectively). Also, a lower percentage of patients in the NAC group had lactate dehydrogenase (LDH) ≤ 245 U/L (0% vs. 25%, P = 0.047). Although the length of ward and ICU stay was shorter in the NAC group than in controls, the difference was statistically insignificant (P = 0.598 and P = 0.629, respectively). Mortality, on the other hand, was 75% in the control group and 50% in the NAC group, with no statistically significant difference (P = 0.102). Concerning the change in the study parameters, only the decrease in diastolic blood pressure (DBP) was significantly higher with NAC (P = 0.042). The intubation and mechanical ventilation rates were higher, while oxygen with mask and nasal oxygen rates were lower with NAC, but the difference was statistically insignificant. Conclusions: Based on the current research, NAC is related to a significant decrease in RR, D-dimer, and DBP in severe COVID-19. Also, LDH was significantly lower in the NAC group than in the controls. More research with larger sample sizes is needed to validate the current study results.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48980180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. M. A. Noori, A. Behfar, Afrooz Saadat, A. Ameri, Seyyed Shahab Atashi Yazdi, A. Siahpoosh
Background: The application of natural antimicrobial and antioxidant agents in food and pharmaceutical products has recently become a trend due to the high demand for them from consumers. Postbiotics are bioactive compounds that are produced when the healthy bacteria in the gut ferment fiber. Objectives: This study aimed to compare the antibacterial and antioxidant properties of postbiotics from 5 different lactic acid bacteria (LAB) including Lactiplantibacillus fermentum, Lactiplantibacillus plantarum, Lactiplantibacillus rhamnosus, Lactobacillus casei, and Lactobacillus acidophilus. Methods: Two different methods were adopted to obtain postbiotics (M1 and M2). M1 was the simple method in which the centrifugation was employed while in M2 method, ethyl acetate was used to obtain postbiotics. Agar disc diffusion, minimum inhibition concentration, and minimum bactericidal concentration were used to assess the antimicrobial activity of postbiotics. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) test was performed in order for investigating the antioxidant property. Results: The best results were recorded for L. casei compared to other LABs. Highest values of the agar disc diffusion method were obtained for L. casei. The inhibition zones for Salmonella enterica, Listeria monocytogenes, and Staphylococcus aureus, for examples, were 22 mm, 20 mm, and 19 mm, respectively. The postbiotic of L. casei also exhibited the most potent antioxidant activity among other probiotic bacteria. The data showed that M2 was a more effective method than the other method for acquiring postbiotics. Conclusions: It was recommended LABs postbiotics should be applied as antioxidant, antimicrobial, and preservatives in food and pharmaceutical industries due to their desired effects and natural characteristics.
{"title":"Antimicrobial and Antioxidant Properties of Natural Postbiotics Derived from Five Lactic Acid Bacteria","authors":"S. M. A. Noori, A. Behfar, Afrooz Saadat, A. Ameri, Seyyed Shahab Atashi Yazdi, A. Siahpoosh","doi":"10.5812/jjnpp-130785","DOIUrl":"https://doi.org/10.5812/jjnpp-130785","url":null,"abstract":"Background: The application of natural antimicrobial and antioxidant agents in food and pharmaceutical products has recently become a trend due to the high demand for them from consumers. Postbiotics are bioactive compounds that are produced when the healthy bacteria in the gut ferment fiber. Objectives: This study aimed to compare the antibacterial and antioxidant properties of postbiotics from 5 different lactic acid bacteria (LAB) including Lactiplantibacillus fermentum, Lactiplantibacillus plantarum, Lactiplantibacillus rhamnosus, Lactobacillus casei, and Lactobacillus acidophilus. Methods: Two different methods were adopted to obtain postbiotics (M1 and M2). M1 was the simple method in which the centrifugation was employed while in M2 method, ethyl acetate was used to obtain postbiotics. Agar disc diffusion, minimum inhibition concentration, and minimum bactericidal concentration were used to assess the antimicrobial activity of postbiotics. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) test was performed in order for investigating the antioxidant property. Results: The best results were recorded for L. casei compared to other LABs. Highest values of the agar disc diffusion method were obtained for L. casei. The inhibition zones for Salmonella enterica, Listeria monocytogenes, and Staphylococcus aureus, for examples, were 22 mm, 20 mm, and 19 mm, respectively. The postbiotic of L. casei also exhibited the most potent antioxidant activity among other probiotic bacteria. The data showed that M2 was a more effective method than the other method for acquiring postbiotics. Conclusions: It was recommended LABs postbiotics should be applied as antioxidant, antimicrobial, and preservatives in food and pharmaceutical industries due to their desired effects and natural characteristics.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43081382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanya Koliji, Zohra Keshavarz, F. Mojab, M. Nasiri, E. Zare
Background: Sexual dysfunction is one of the most common problems following menopause. This study aimed to evaluate the effect of cinnamon and vitex on improving sexual function in postmenopausal women. Methods: This study was a randomized triple-blind clinical trial with a control group. Randomized sampling was used to allocate postmenopausal women into three cinnamon, vitex, and placebo groups of 35. A sexual function index was utilized before and two and three months after the intervention to assess sexual functioning. SPSS version 21 software was used for analysis. Results: The mean age was 54.45 ± 3.73 years. The overall sexual function score in the two cinnamon and vitex groups showed a statistically significant difference before and after treatment compared to the placebo group (P < 0.00). In the vitex group, sexual desire (P = 0.00) and arousal (P = 0.02) increased significantly compared to pre-intervention, and this significant increase was observed in the cinnamon group in lubricity (P = 0.00) and sexual satisfaction (P = 0.03). Conclusions: Cinnamon and vitex are effective medicinal herbs to alleviate sexual function.
{"title":"Comparison of Cinnamon and Vitex on Improving Sexual Function in Postmenopausal Women: A Triple-blind Randomized Clinical Trial","authors":"Tanya Koliji, Zohra Keshavarz, F. Mojab, M. Nasiri, E. Zare","doi":"10.5812/jjnpp-128406","DOIUrl":"https://doi.org/10.5812/jjnpp-128406","url":null,"abstract":"Background: Sexual dysfunction is one of the most common problems following menopause. This study aimed to evaluate the effect of cinnamon and vitex on improving sexual function in postmenopausal women. Methods: This study was a randomized triple-blind clinical trial with a control group. Randomized sampling was used to allocate postmenopausal women into three cinnamon, vitex, and placebo groups of 35. A sexual function index was utilized before and two and three months after the intervention to assess sexual functioning. SPSS version 21 software was used for analysis. Results: The mean age was 54.45 ± 3.73 years. The overall sexual function score in the two cinnamon and vitex groups showed a statistically significant difference before and after treatment compared to the placebo group (P < 0.00). In the vitex group, sexual desire (P = 0.00) and arousal (P = 0.02) increased significantly compared to pre-intervention, and this significant increase was observed in the cinnamon group in lubricity (P = 0.00) and sexual satisfaction (P = 0.03). Conclusions: Cinnamon and vitex are effective medicinal herbs to alleviate sexual function.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46563614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zeinab Houshialsadat, P. Mirmiran, A. Zare-Javid, Z. Bahadoran, C. Houghton
Context: Cruciferous vegetables are complementary dietary therapies for disease prevention and health promotion. Sulforaphane-yielding broccoli sprouts are gaining popularity in managing cardiometabolic diseases. Objectives: Given the increasing prevalence of cardiometabolic diseases worldwide, this systematic review and meta-analysis aimed to study the cardiometabolic implications of broccoli sprout supplementation within the literature. Methods: Eligible literature was retrieved through Pubmed and Scopus up to June 2022. Results: Ten clinical trials investigating broccoli sprout supplementation and cardiometabolic health among human subjects were extracted for meta-analysis. The earliest study was published in 2004, and the most recent was released in 2019. Seven studies included control groups for valid comparison. Overall, the dietary intake of broccoli sprouts significantly reduced systolic (-10.9 mmHg; 95% confidence interval (CI): -17.0, -4.86) and diastolic (-6.95 mmHg; 95% CI: -10.6, -3.28) blood pressures. Marginally significant changes were also detected in blood lipid biomarkers compared to the baseline. Conclusions: Our results confirm the hypotensive properties of broccoli sprout and highlight the potential sulforaphane-dependent effects of this vegetable.
{"title":"Beneficial Effects of Sulforaphane-Yielding Broccoli Sprout on Cardiometabolic Health: A Systematic Review and Meta-Analysis","authors":"Zeinab Houshialsadat, P. Mirmiran, A. Zare-Javid, Z. Bahadoran, C. Houghton","doi":"10.5812/jjnpp-129402","DOIUrl":"https://doi.org/10.5812/jjnpp-129402","url":null,"abstract":"Context: Cruciferous vegetables are complementary dietary therapies for disease prevention and health promotion. Sulforaphane-yielding broccoli sprouts are gaining popularity in managing cardiometabolic diseases. Objectives: Given the increasing prevalence of cardiometabolic diseases worldwide, this systematic review and meta-analysis aimed to study the cardiometabolic implications of broccoli sprout supplementation within the literature. Methods: Eligible literature was retrieved through Pubmed and Scopus up to June 2022. Results: Ten clinical trials investigating broccoli sprout supplementation and cardiometabolic health among human subjects were extracted for meta-analysis. The earliest study was published in 2004, and the most recent was released in 2019. Seven studies included control groups for valid comparison. Overall, the dietary intake of broccoli sprouts significantly reduced systolic (-10.9 mmHg; 95% confidence interval (CI): -17.0, -4.86) and diastolic (-6.95 mmHg; 95% CI: -10.6, -3.28) blood pressures. Marginally significant changes were also detected in blood lipid biomarkers compared to the baseline. Conclusions: Our results confirm the hypotensive properties of broccoli sprout and highlight the potential sulforaphane-dependent effects of this vegetable.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41973304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mohammadi, Y. Yahyapour, Sina Nasrollahian, Mohammad Hossein Tayefeh-Arbab, M. Javanian, Mohammad Rajabi Fadardi, Seyedeh Nasim Mousavi Kani, Parisa Honarvar Bakeshloo, R. Saghebi, Mehdi Rajabnia, M. Halaji, Abazar Pournajaf
Context: An outbreak of the new coronavirus disease 2019 (COVID-19) was reported in Wuhan, China, in December 2019, subsequently affecting countries worldwide and causing a pandemic. Although several vaccines, such as mRNA vaccines, inactivated vaccines, and adenovirus vaccines, have been licensed in several countries, the danger of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants persists. To date, Alpha (B.1.1.7), Beta (B.1.351, B.1.351.2, B.1.351.3), Delta (B.1.617.2, AY.1, AY.2, AY. 3), Gamma (P.1, P.1.1, P.1.2), and Iota (B.1 .526) circulating in the United States, Kappa (B.1.617.1) in India, Lambda (C.37) in Peru and Mu (B.1.621) in Colombia are considered the variants of concern and interest. Evidence Acquisition: Data were collected through the end of August 2021 by searching PubMed, Scopus, and Google Scholar databases. There were findings from in silico, in vitro cell-based, and non-cell-based investigations. Results: The potential and safety profile of herbal medicines need clarification to scientifically support future recommendations regarding the benefits and risks of their use. Conclusions: Current research results on natural products against SARS-CoV-2 and variants are discussed, and their specific molecular targets and possible mechanisms of action are summarized.
{"title":"A Review on Herbal Secondary Metabolites Against COVID-19 Focusing on the Genetic Variants of SARS-CoV-2","authors":"M. Mohammadi, Y. Yahyapour, Sina Nasrollahian, Mohammad Hossein Tayefeh-Arbab, M. Javanian, Mohammad Rajabi Fadardi, Seyedeh Nasim Mousavi Kani, Parisa Honarvar Bakeshloo, R. Saghebi, Mehdi Rajabnia, M. Halaji, Abazar Pournajaf","doi":"10.5812/jjnpp-129618","DOIUrl":"https://doi.org/10.5812/jjnpp-129618","url":null,"abstract":"Context: An outbreak of the new coronavirus disease 2019 (COVID-19) was reported in Wuhan, China, in December 2019, subsequently affecting countries worldwide and causing a pandemic. Although several vaccines, such as mRNA vaccines, inactivated vaccines, and adenovirus vaccines, have been licensed in several countries, the danger of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants persists. To date, Alpha (B.1.1.7), Beta (B.1.351, B.1.351.2, B.1.351.3), Delta (B.1.617.2, AY.1, AY.2, AY. 3), Gamma (P.1, P.1.1, P.1.2), and Iota (B.1 .526) circulating in the United States, Kappa (B.1.617.1) in India, Lambda (C.37) in Peru and Mu (B.1.621) in Colombia are considered the variants of concern and interest. Evidence Acquisition: Data were collected through the end of August 2021 by searching PubMed, Scopus, and Google Scholar databases. There were findings from in silico, in vitro cell-based, and non-cell-based investigations. Results: The potential and safety profile of herbal medicines need clarification to scientifically support future recommendations regarding the benefits and risks of their use. Conclusions: Current research results on natural products against SARS-CoV-2 and variants are discussed, and their specific molecular targets and possible mechanisms of action are summarized.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45875645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Delaram Poorkazemi, Ali Malekzadeh Shafaroudi, Pegah Nasiri, M. Aarabi, Javad Mehrani Sabet
Context: Mouth rinses have been recognized as the main adjuvant or primary treatment to address many issues relating to dentistry. Previous studies have investigated the anti-inflammatory, anti-arthritic, anti-viral, antioxidant, anti-fungal, and anti-bacterial effects of Aloe vera. Recently, Aloe vera has been applied to treat several dental and oral conditions. Methods: Official web pages, such as Scopus, PubMed, and Microsoft were searched for collecting the required data using the keywords Aloe vera, Aloe vera mouthwash, Aloe vera mouth rinse, and dentistry. After checking the abstracts and titles, all relevant papers were retrieved for performing a full-text review. Results: Aloe vera was effective in reducing periodontal indices compared to chlorhexidine. It was also effective in treating oral diseases such as mucositis, postoperative pain, trismus, and dry socket incidence after the third molar extraction. Aloe vera decreased the number of colony-forming units during scaling and root planning (SRP). Conclusions: Aloe vera mouthwash was just as effective as other commercial mouthwashes in reducing the severity of radiation-induced mucositis, periodontal disease, the amount of S. mutans, the number of colony-forming units during SRP, and other situations which required a mouth rinse for the acceleration of treatment.
{"title":"Evaluation of Aloe vera as a Natural Pharmaceutic in Mouthwashes: A Narrative Review","authors":"Delaram Poorkazemi, Ali Malekzadeh Shafaroudi, Pegah Nasiri, M. Aarabi, Javad Mehrani Sabet","doi":"10.5812/jjnpp-122155","DOIUrl":"https://doi.org/10.5812/jjnpp-122155","url":null,"abstract":"Context: Mouth rinses have been recognized as the main adjuvant or primary treatment to address many issues relating to dentistry. Previous studies have investigated the anti-inflammatory, anti-arthritic, anti-viral, antioxidant, anti-fungal, and anti-bacterial effects of Aloe vera. Recently, Aloe vera has been applied to treat several dental and oral conditions. Methods: Official web pages, such as Scopus, PubMed, and Microsoft were searched for collecting the required data using the keywords Aloe vera, Aloe vera mouthwash, Aloe vera mouth rinse, and dentistry. After checking the abstracts and titles, all relevant papers were retrieved for performing a full-text review. Results: Aloe vera was effective in reducing periodontal indices compared to chlorhexidine. It was also effective in treating oral diseases such as mucositis, postoperative pain, trismus, and dry socket incidence after the third molar extraction. Aloe vera decreased the number of colony-forming units during scaling and root planning (SRP). Conclusions: Aloe vera mouthwash was just as effective as other commercial mouthwashes in reducing the severity of radiation-induced mucositis, periodontal disease, the amount of S. mutans, the number of colony-forming units during SRP, and other situations which required a mouth rinse for the acceleration of treatment.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48038587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Rezaei, M. Sheikholeslami, Ebrahim Salimi-Sabour, E. Lotfali, S. Parvardeh
Background: Opioids are the principal drugs of choice for managing acute severe pain; however, physical dependence is still reported as one of the main limiting factors in the clinical application of these drugs. In the present study, the effect of Ganoderma lucidum (G. lucidum) was assessed on morphine dependence in mice. Methods: A 19-day administration schedule was applied to induce morphine dependence in male adult NMRI mice. The mice were given intraperitoneal (i.p.) morphine sulfate once daily in an increasing dose of 10, 20, and 40 mg/kg. Then, G. lucidum hydroalcoholic extract (12.5, 25, and 50 mg/kg, i.p.) was given to the mice from days 10 to 18. Another group of mice received single doses of the extract (50, 100, and 200 mg/kg, i.p.) only on the 19th day. Naloxone (3 mg/kg, i.p.) was used to precipitate withdrawal syndrome. Normal saline and diazepam (0.25 mg/kg) were used as the negative and positive controls, respectively. Results: The administration of single doses of G. lucidum extract (100 and 200 mg/kg, i.p.) significantly decreased the number of jumps, leanings, and diarrhea in mice subjected to morphine dependence. The repeated administration of G. lucidum extract (25 and 50 mg/kg for nine days) significantly attenuated the number of jumps, leanings, and diarrhea in morphine-dependent mice. Conclusions: Overall, G. lucidum extract attenuates induced morphine dependence and inhibits withdrawal syndrome symptoms in mice.
{"title":"Attenuation of Morphine Dependence by Ganoderma lucidum Extract in Mice","authors":"K. Rezaei, M. Sheikholeslami, Ebrahim Salimi-Sabour, E. Lotfali, S. Parvardeh","doi":"10.5812/jjnpp-123164","DOIUrl":"https://doi.org/10.5812/jjnpp-123164","url":null,"abstract":"Background: Opioids are the principal drugs of choice for managing acute severe pain; however, physical dependence is still reported as one of the main limiting factors in the clinical application of these drugs. In the present study, the effect of Ganoderma lucidum (G. lucidum) was assessed on morphine dependence in mice. Methods: A 19-day administration schedule was applied to induce morphine dependence in male adult NMRI mice. The mice were given intraperitoneal (i.p.) morphine sulfate once daily in an increasing dose of 10, 20, and 40 mg/kg. Then, G. lucidum hydroalcoholic extract (12.5, 25, and 50 mg/kg, i.p.) was given to the mice from days 10 to 18. Another group of mice received single doses of the extract (50, 100, and 200 mg/kg, i.p.) only on the 19th day. Naloxone (3 mg/kg, i.p.) was used to precipitate withdrawal syndrome. Normal saline and diazepam (0.25 mg/kg) were used as the negative and positive controls, respectively. Results: The administration of single doses of G. lucidum extract (100 and 200 mg/kg, i.p.) significantly decreased the number of jumps, leanings, and diarrhea in mice subjected to morphine dependence. The repeated administration of G. lucidum extract (25 and 50 mg/kg for nine days) significantly attenuated the number of jumps, leanings, and diarrhea in morphine-dependent mice. Conclusions: Overall, G. lucidum extract attenuates induced morphine dependence and inhibits withdrawal syndrome symptoms in mice.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45239449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Malayeri, F. Golfakhrabadi, Z. Basir, Tohid Movahhed, Zeinab Zaheri Abdevand
Background: Persian oak (Quercus castaneifolia C.A.Mey) belongs to the Fagaceae family. This plant is commonly used in Iranian traditional medicine to treat inflammatory and gastric ulcers. Objectives: This study aimed to assess the efficacy of Persian oak fruit aqueous hull extract on wound healing in rats. Methods: Thirty-five male Wistar rats were randomly divided into five groups, then two full-thickness wounds of 10 mm in diameter were created bilaterally on the back of the animals. The negative control group received saline, the positive control group was treated with phenytoin cream, and three treatment groups received 2%, 4%, and 8% Jaft aqueous extract. The animals received these medicines once daily for 15 days. The percentage of wound healing was evaluated using wound contraction ratio, re-epithelialization, tensile strength, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) content. Histopathological examination was performed on repaired tissues. Results: In the 2%, 4%, and 8% Jaft extract and the phenytoin groups, the wound closure rate was significantly higher than in the saline group. The treatment groups revealed significant healing improvement (P < 0.05) compared to the control group in wound contraction, tensile strength, epithelialization duration, VEGF, and PDGF plasma level. Histopathological investigations also exhibited development in wound healing with Jaft extract. Conclusions: This study shows that the Persian oak fruit hull aqueous extract was effective in wound healing in animal models. Clinical trials are required to prove the efficacy of Q. castaneifolia fruit hull spray in healing various wounds in humans.
{"title":"Evaluating the Effectiveness of Aqueous Extract of Persian Oak (Quercus castaneifolia C.A.Mey.) Fruit Hull on Dermal Wound Healing in the Rat Model","authors":"A. Malayeri, F. Golfakhrabadi, Z. Basir, Tohid Movahhed, Zeinab Zaheri Abdevand","doi":"10.5812/jjnpp-127426","DOIUrl":"https://doi.org/10.5812/jjnpp-127426","url":null,"abstract":"Background: Persian oak (Quercus castaneifolia C.A.Mey) belongs to the Fagaceae family. This plant is commonly used in Iranian traditional medicine to treat inflammatory and gastric ulcers. Objectives: This study aimed to assess the efficacy of Persian oak fruit aqueous hull extract on wound healing in rats. Methods: Thirty-five male Wistar rats were randomly divided into five groups, then two full-thickness wounds of 10 mm in diameter were created bilaterally on the back of the animals. The negative control group received saline, the positive control group was treated with phenytoin cream, and three treatment groups received 2%, 4%, and 8% Jaft aqueous extract. The animals received these medicines once daily for 15 days. The percentage of wound healing was evaluated using wound contraction ratio, re-epithelialization, tensile strength, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) content. Histopathological examination was performed on repaired tissues. Results: In the 2%, 4%, and 8% Jaft extract and the phenytoin groups, the wound closure rate was significantly higher than in the saline group. The treatment groups revealed significant healing improvement (P < 0.05) compared to the control group in wound contraction, tensile strength, epithelialization duration, VEGF, and PDGF plasma level. Histopathological investigations also exhibited development in wound healing with Jaft extract. Conclusions: This study shows that the Persian oak fruit hull aqueous extract was effective in wound healing in animal models. Clinical trials are required to prove the efficacy of Q. castaneifolia fruit hull spray in healing various wounds in humans.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44422370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shahnaz kheirkhah Rahimabadi, A. S. Tabatabaee Bafroee, B. Khalili Hadad
Background: Replacing all or part of synthetic preservatives with natural antimicrobials in pharmaceutical formulations can be a way to improve the safety and quality of products. Evaluating the preservative effectiveness of essential oils is valuable since most of them are generally known to be safe. Objectives: In the current research, the efficacy of Eucalyptus globulus essential oil was investigated as an antimicrobial agent individually and in combination with benzalkonium chloride in fluticasone propionate nasal spray. Methods: To determine the minimum inhibitory concentration (MIC) of E. globulus essential oil, in vitro antimicrobial activity was assayed. The stability of nasal sprays was studied in intended preservation conditions at 40°C and RH: 25 %, and also the microbial challenge test was performed according to the United States Pharmacopoeia procedure, using reference strains: Staphylococcus aureus ATCC 1112, Escherichia coli ATCC 1330, Pseudomonas aeruginosa ATCC 1074, Candida albicans ATCC 5027, and Aspergillus brasiliensis ATCC 5011. Results: The combined application of E. globulus essential oil and benzalkonium chloride at a concentration of 0.675/0.005% v/v, in nasal spray formulation could decrease the bacterial and fungal populations, in compliance with United States Pharmacopoeia criteria, with considerable preservation within 28 days of the study compared to those preserved with only benzalkonium chloride (0.02%). Conclusions: In the current research, notable antimicrobial effectiveness of the combinational preservative system was observed and followed by a decrease in the functional level of the synthetic preservative. Therefore, after further studies, a combinational preservative system can be considered as an alternative preservative for pharmaceutical formulations.
{"title":"Development of a Natural Preservative System in Fluticasone Propionate Nasal Spray Formulation Using Eucalyptus globulus Essential Oil","authors":"Shahnaz kheirkhah Rahimabadi, A. S. Tabatabaee Bafroee, B. Khalili Hadad","doi":"10.5812/jjnpp-127106","DOIUrl":"https://doi.org/10.5812/jjnpp-127106","url":null,"abstract":"Background: Replacing all or part of synthetic preservatives with natural antimicrobials in pharmaceutical formulations can be a way to improve the safety and quality of products. Evaluating the preservative effectiveness of essential oils is valuable since most of them are generally known to be safe. Objectives: In the current research, the efficacy of Eucalyptus globulus essential oil was investigated as an antimicrobial agent individually and in combination with benzalkonium chloride in fluticasone propionate nasal spray. Methods: To determine the minimum inhibitory concentration (MIC) of E. globulus essential oil, in vitro antimicrobial activity was assayed. The stability of nasal sprays was studied in intended preservation conditions at 40°C and RH: 25 %, and also the microbial challenge test was performed according to the United States Pharmacopoeia procedure, using reference strains: Staphylococcus aureus ATCC 1112, Escherichia coli ATCC 1330, Pseudomonas aeruginosa ATCC 1074, Candida albicans ATCC 5027, and Aspergillus brasiliensis ATCC 5011. Results: The combined application of E. globulus essential oil and benzalkonium chloride at a concentration of 0.675/0.005% v/v, in nasal spray formulation could decrease the bacterial and fungal populations, in compliance with United States Pharmacopoeia criteria, with considerable preservation within 28 days of the study compared to those preserved with only benzalkonium chloride (0.02%). Conclusions: In the current research, notable antimicrobial effectiveness of the combinational preservative system was observed and followed by a decrease in the functional level of the synthetic preservative. Therefore, after further studies, a combinational preservative system can be considered as an alternative preservative for pharmaceutical formulations.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46207741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Hakimin Shafie, M. Kamal, Nursayidatul Arisya Abdul Razak, S. Hasan, N. H. Uyup, N. Abdul Rashid, Z. Zafarina
Context: Hydrosol is a residual product from the steam or hydro distillation process of abundant types of plants. It can be separated from the essential oil mixture by the liquid-liquid extraction process. Hydrosols from a variety of plants are becoming increasingly popular in cosmetology, aromatherapy, traditional pharmacy, and food sector; thus, their prospective applications should be further explored. Evidence Acquisition: Hydrosol may generally contain chemicals such as alcohol, ketone, and ester. Based on the previous studies using gas chromatography-mass spectroscopy (GC-MS) analysis, linalool, carvacrol, and α-terpineol are the major chemicals present in plant hydrosol. Results: The chemical composition is either showing antimicrobial or antioxidant properties. The antioxidant properties are important in cosmeceutical products to prevent oxidation of the cosmetic ingredients, while the antimicrobial properties maintain the quality of the cosmetics. Hitherto, hydrosol usage is still unfamiliar in the market, but several cosmetic products have been formulated using hydrosol, such as shampoo, soap, and conditioner. Conclusions: This work will review the hydrosol compound from plants, extraction methods, chemical composition, antioxidant and antimicrobial activities, and the potential of hydrosol in cosmeceutical application.
{"title":"Antioxidant and Antimicrobial Activity of Plant Hydrosol and Its Potential Application in Cosmeceutical Products","authors":"Muhammad Hakimin Shafie, M. Kamal, Nursayidatul Arisya Abdul Razak, S. Hasan, N. H. Uyup, N. Abdul Rashid, Z. Zafarina","doi":"10.5812/jjnpp-124018","DOIUrl":"https://doi.org/10.5812/jjnpp-124018","url":null,"abstract":"Context: Hydrosol is a residual product from the steam or hydro distillation process of abundant types of plants. It can be separated from the essential oil mixture by the liquid-liquid extraction process. Hydrosols from a variety of plants are becoming increasingly popular in cosmetology, aromatherapy, traditional pharmacy, and food sector; thus, their prospective applications should be further explored. Evidence Acquisition: Hydrosol may generally contain chemicals such as alcohol, ketone, and ester. Based on the previous studies using gas chromatography-mass spectroscopy (GC-MS) analysis, linalool, carvacrol, and α-terpineol are the major chemicals present in plant hydrosol. Results: The chemical composition is either showing antimicrobial or antioxidant properties. The antioxidant properties are important in cosmeceutical products to prevent oxidation of the cosmetic ingredients, while the antimicrobial properties maintain the quality of the cosmetics. Hitherto, hydrosol usage is still unfamiliar in the market, but several cosmetic products have been formulated using hydrosol, such as shampoo, soap, and conditioner. Conclusions: This work will review the hydrosol compound from plants, extraction methods, chemical composition, antioxidant and antimicrobial activities, and the potential of hydrosol in cosmeceutical application.","PeriodicalId":17745,"journal":{"name":"Jundishapur Journal of Natural Pharmaceutical Products","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2022-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47166348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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