Kuwait Journal of Science最新文献_第3页

RSM based optimization for sustainable removal of Cr(VI) and Pb(II) from tannery effluent using rotating disk mesh electrode by electrocoagulation 基于RSM的旋转圆盘网电极电絮凝法去除制革废水中Cr（VI）和Pb（II）的优化研究

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science

Pub Date : 2025-11-26 DOI: 10.1016/j.kjs.2025.100518

Arshad Iqbal , Khadija Qureshi , Zulfiqar Ali Bhatti , Abdul Qadeer Laghari , Imran Nazir Unar , Abdul Sattar Jatoi , Muhammad Azam Usto , Zubair Hashmi

The tanning process involves the usage of various toxic chemicals, disrupting concentrations in the ecosystem. The aim of this research was to develop an efficient electrode design and utilize it as an anode for treating chromium (Cr) and lead (Pb) present in tannery effluent through the electrocoagulation process in a sustainable manner and utilize the resulting sludge for pigment application. Performance of electrodes was analyzed using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). The electrode's surface morphology and chemical composition were analyzed using SEM and EDX techniques, respectively. The SEM analysis revealed that the newly developed rotating disk mesh electrode (RDME) exhibited minimal scaling of contaminant and oxide layer of metal formation on its surface and better removal performance of chromium and lead from tannery effluent. EDX shows the evidence of elements attached due to passivation and the metal oxide layer in effluent. Furthermore, the process parameters optimized were current density, pH, RPM, and treatment time using the Box-Behnkin Design method with Design Expert 13.6 software. At optimized conditions with a current density of 19.26 mA/cm², pH of 7, RPM of 160, and treatment time of 90 min, the rotating disk mesh electrode demonstrated impressive Cr and Pb removal efficiencies of 90 % and 94 % respectively. Moreover, the energy consumption for treatment of Cr and Pb were 31.75 kWh/m³ for the rotating disk mesh electrode (RDME). It showed great potential of the rotating disk mesh electrode design as the optimal choice for commercial-scale application, offering efficient removal and less energy consuming process for the removal of Cr and Pb from tannery effluent through the electrocoagulation process.

制革过程涉及使用各种有毒化学物质，破坏生态系统的浓度。本研究的目的是开发一种高效的电极设计，并利用它作为阳极，通过电凝工艺以可持续的方式处理制革厂废水中的铬（Cr）和铅（Pb），并利用产生的污泥用于颜料应用。利用扫描电子显微镜（SEM）和能量色散x射线能谱（EDX）分析了电极的性能。利用SEM和EDX技术对电极的表面形貌和化学成分进行了分析。扫描电镜分析表明，新开发的旋转圆盘网状电极（RDME）具有最小的污染物结垢和表面形成的金属氧化层，具有较好的去除制革废水中铬和铅的性能。EDX显示了由于钝化和流出物中的金属氧化层而附着的元素的证据。采用Box-Behnkin Design方法，利用Design Expert 13.6软件对电流密度、pH、转速、处理时间等工艺参数进行优化。在电流密度为19.26 mA/cm2， pH为7，转速为160，处理时间为90 min的优化条件下，旋转圆盘网状电极的Cr和Pb去除效率分别达到90%和94%。旋转圆盘网状电极（RDME）处理Cr和Pb的能耗为31.75 kWh/m3。通过电絮凝法去除制革废水中的铬和铅，显示了旋转圆盘网状电极设计作为商业规模应用的最佳选择的巨大潜力。

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引用次数: 0

Professionalism conduct on social networks before and after COVID-19 for healthcare practitioners 新型冠状病毒肺炎前后医护人员在社交网络上的职业操守

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science

Pub Date : 2025-11-25 DOI: 10.1016/j.kjs.2025.100513

Fatemah Husain

Social networks have revolutionized numerous activities in daily life, affecting the behavior of professional conduct. Professionals, especially healthcare practitioners, directly impact the health and well-being of community members through online social network sites (SNSs). However, limited studies have considered the use of SNS by healthcare professionals, especially during the Coronavirus disease pandemic (COVID-19). Understanding how healthcare professionals use SNSs is crucial, as it can influence public health communication and education. By studying their SNS interactions, we can gain insight into how information is disseminated and how it impacts patient care and community health outcomes. Furthermore, this knowledge can help develop guidelines to improve the effective and responsible use of SNSs in the medical field. To understand the effect of COVID-19 on the behavior of healthcare professionals in SNSs for medical and healthcare purposes, we conducted a comprehensive survey based on the technology acceptance model (TAM), which is a theory of information systems used to explain how users come to accept and utilize technology. It focuses on two key factors: perceived usefulness (how much a person believes a technology will improve their performance) and perceived ease of use (how easy the technology is to use). We developed a cross-sectional survey covering two samples from Kuwaiti healthcare professionals before and after COVID-19. The results of the study suggest that physicians do not strongly favor using SNS as a healthcare tool, neither before nor after COVID-19. Therefore, it is essential to promote greater awareness of healthcare in the SNS. It is also important to study the needs of healthcare professionals so that they can positively employ SNSs for healthcare.

社交网络已经彻底改变了日常生活中的许多活动，影响了职业行为的行为。专业人员，特别是医疗保健从业人员，通过在线社交网络站点（sns）直接影响社区成员的健康和福祉。然而，有限的研究考虑了医疗保健专业人员使用SNS，特别是在冠状病毒病大流行（COVID-19）期间。了解医疗保健专业人员如何使用社交网站至关重要，因为它可以影响公共卫生沟通和教育。通过研究他们的社交网络互动，我们可以深入了解信息是如何传播的，以及它是如何影响患者护理和社区健康结果的。此外，这些知识有助于制定准则，以改进医疗领域对社交网络的有效和负责任的使用。为了了解COVID-19对医疗保健目的的社交网站中医护人员行为的影响，我们基于技术接受模型（TAM）进行了一项全面调查，技术接受模型是一种用于解释用户如何接受和利用技术的信息系统理论。它关注两个关键因素：感知有用性（一个人相信一项技术能在多大程度上提高他们的性能）和感知易用性（该技术使用起来有多容易）。我们开展了一项横断面调查，涵盖了在COVID-19之前和之后来自科威特卫生保健专业人员的两个样本。研究结果表明，无论是在COVID-19之前还是之后，医生都不太赞成使用SNS作为医疗工具。因此，在社交网络中提高医疗保健意识至关重要。研究医疗保健专业人员的需求也很重要，这样他们就可以积极地雇用社交网站从事医疗保健工作。

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引用次数: 0

In silico insights into (±)-zanthonitidumine B: anti-Inflammatory potency and enantiomeric selectivity through molecular docking, DFT, and MEP studies （±）-zanthonitidumine B：通过分子对接、DFT和MEP研究的抗炎效力和对映体选择性

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science

Pub Date : 2025-11-21 DOI: 10.1016/j.kjs.2025.100516

Maram B. Alhawarri , Amit Dubey , Aisha Tufail , Mohammad G. Al-Thiabat

Inflammation becomes pathogenic when dysregulated, with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) acting as central mediators. (±)-Zanthonitidumine B, a racemic benzophenanthridine alkaloid from Zanthoxylum nitidum, has been reported to suppress these cytokines. In this study, the enantiomers (+)-zanthonitidumine B and (−)-zanthonitidumine B were investigated using molecular docking supported by density functional theory (DFT) and molecular electrostatic potential (MEP) analyses. Docking simulations against TNF-α (PDB: 6X86; validated by redocking of the co-crystallized ligand, ΔG_bind = −13.13 kcal/mol) revealed that (−)-zanthonitidumine B exhibited stronger (more negative) binding (ΔG_bind = −10.73 kcal/mol) than (+)-zanthonitidumine B (ΔG_bind = −8.68 kcal/mol), forming a hydrogen bond with Tyr:119 (2.61 Å) and multiple hydrophobic contacts. Against IL-6 (PDB: 1ALU), both enantiomers showed comparable affinities [(+): 7.76 kcal/mol; (−): 7.64 kcal/mol] but distinct binding modes— (+)-zanthonitidumine B interacting with Gln:127/Ile:136 and (−)-zanthonitidumine B with Asp:140 and π–σ contacts at Leu:147. DFT results indicated a smaller HOMO–LUMO gap for (−)-zanthonitidumine B (2.71 eV) compared to (+)-zanthonitidumine B (1.97 eV), while MEP maps highlighted electron-rich regions near oxygen atoms, rationalizing the observed interaction hot spots. Collectively, these in silico results nominate (−)-zanthonitidumine B as the stronger TNF-α binder and suggest comparable IL-6 engagement for both enantiomers, providing stereochemical hypotheses to guide future chiral isolation and in vitro anti-inflammatory validation.

在白细胞介素-6 （IL-6）和肿瘤坏死因子-α (TNF-α)作为中心介质的作用下，炎症在失调时变得具有致病性。（±）-Zanthonitidumine B是一种外消旋苯并苯胺生物碱，据报道可以抑制这些细胞因子。本研究采用密度泛函理论（DFT）和分子静电势（MEP）分析，对(+)- zananthonitidumine B和(−)- zananthonitidumine B进行了分子对接研究。与TNF-α （PDB: 6X86；通过共结晶配体的重新对接验证，ΔGbind =−13.13 kcal/mol）的对接模拟表明，(−)- zananthonitidumine B比(+)- zananthonitidumine B （ΔGbind =−8.68 kcal/mol）具有更强（更负）的结合（ΔGbind =−10.73 kcal/mol），与Tyr:119 （2.61 Å）形成氢键和多个疏水接触。对IL-6 (PDB: 1ALU)，两种对映体的亲和力相当[(+):7.76 kcal/mol；（−）：7.64 kcal/mol]，但不同的结合模式- (+)- zananthonitidumine B与Gln:127/Ile:136和(−)- zananthonitidumine B与Asp:140和π - σ接触Leu:147。DFT结果表明(−)-zanthonitidumine B的HOMO-LUMO间隙（2.71 eV）小于(+)-zanthonitidumine B (1.97 eV)，而MEP图突出了氧原子附近的富电子区域，使观察到的相互作用热点更加合理。总的来说，这些硅结果表明(−)-zanthonitidumine B是更强的TNF-α结合剂，并表明两种对映体具有相似的IL-6结合作用，为指导未来的手性分离和体外抗炎验证提供了立体化学假设。

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引用次数: 0

On tempered fractional Bullen-type inequalities: analysis in different function settings 缓变分数bullen型不等式：不同函数设置下的分析

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science

Pub Date : 2025-11-21 DOI: 10.1016/j.kjs.2025.100515

Abdelghani Lakhdari , Mehmet Zeki Sarikaya , Hüseyin Budak , Badreddine Meftah

Tempered fractional integrals offer a flexible and physically realistic extension of classical fractional operators by incorporating an exponential tempering factor that attenuates long-range memory effects. This modification not only ensures better convergence and numerical stability but also allows for more accurate modeling of real-world phenomena such as anomalous diffusion, financial returns, or geophysical processes, where power-law behaviors are observed but truncated at large scales. This study advances Bullen-type inequalities within the framework of tempered fractional calculus. By formulating a novel identity based on tempered operators, we derive generalized estimates applicable to various function classes, including those with convex or bounded derivatives,

r

-

L

-Hölderian functions, and functions of bounded variation. The inclusion of exponential tempering parameters refines classical Bullen results by balancing non-local effects with convergence guarantees. To illustrate their applicability, these bounds are applied to special means, highlighting how convexity constraints help stabilize tempered fractional integrals in practical contexts.

回火分数积分提供了一个灵活的和物理上现实的扩展经典分数运算符通过纳入一个指数回火因子，衰减长期记忆效应。这种修改不仅确保了更好的收敛性和数值稳定性，而且还允许更准确地模拟现实世界的现象，如异常扩散、金融回报或地球物理过程，其中幂律行为被观察到，但在大尺度上被截断。本研究在缓变分数微积分的框架内提出了bullen型不等式。通过构造一个基于调质算子的新恒等式，我们得到了适用于各种函数类的广义估计，包括凸导数或有界导数、r-L-Hölderian函数和有界变分函数。通过平衡非局部效应和收敛保证，指数回火参数的加入改进了经典的布伦结果。为了说明它们的适用性，这些边界被应用于特殊的方法，突出了凸性约束在实际环境中如何帮助稳定缓和分数阶积分。

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引用次数: 0

Identification and evaluation of natural compounds in the bud extract of Capparis spinosa L. native to Iran for obesity management 伊朗产甜辣椒芽提取物中用于肥胖治疗的天然化合物的鉴定与评价

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science

Pub Date : 2025-11-20 DOI: 10.1016/j.kjs.2025.100517

Ameneh Khodadadi, Akbar Esmaeili

This study examines the Capparis spinosa plant, prevalent in various regions of Iran, to evaluate its bud extract as a potential adjunctive treatment for obesity, a condition associated with significant health risks, including cardiovascular diseases. Gas chromatography-mass spectrometry (GC-MS) identified key compounds, including α-thujene and limonene, which may contribute to anti-obesity effects. The antioxidant capacity was assessed using the ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and hydrogen peroxide assays. The extract's antimicrobial properties were tested against six bacterial strains and Candida albicans using the disk diffusion method, which determined the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Results suggest that C. spinosa bud extract may serve as a promising complementary therapy for obesity. The extract demonstrated significant antibacterial and antifungal activity against bacterial strains, including Bacillus cereus, Escherichia coli, and Staphylococcus aureus. Key compounds are believed to enhance its antimicrobial effectiveness. The extract exhibited a clear zone of inhibition in Mueller-Hinton agar, indicating its capacity to inhibit microbial growth. The MIC and MBC results confirmed its bactericidal and fungicidal properties, supporting its potential use in traditional medicine. Further investigations should delve into the diverse applications and mechanisms of C. spinosa extract in addressing obesity and microbial infections. This study provides a comprehensive evaluation of the bud extract of C. spinosa, focusing on its antioxidant and antimicrobial properties, which have not been extensively studied in the context of obesity management.

本研究考察了在伊朗各个地区普遍存在的Capparis spinosa植物，以评估其芽提取物作为肥胖（一种与心血管疾病等重大健康风险相关的疾病）的潜在辅助治疗。气相色谱-质谱联用（GC-MS）鉴定出可能具有抗肥胖作用的关键化合物，包括α-thujene和柠檬烯。通过铁还原抗氧化能力（FRAP）、2,2-二苯基-1-苦味酰肼（DPPH）和过氧化氢测定来评估其抗氧化能力。采用纸片扩散法测定提取物对6种细菌和白色念珠菌的抑菌性能，确定其最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。结果表明，棘花蕾提取物可能是一种很有前景的肥胖补充疗法。该提取物对蜡样芽孢杆菌、大肠杆菌和金黄色葡萄球菌等细菌具有显著的抗菌和抗真菌活性。关键化合物被认为可以增强其抗菌效果。该提取物在muller - hinton琼脂中表现出明显的抑制区，表明其具有抑制微生物生长的能力。MIC和MBC的结果证实了其杀菌和杀真菌的特性，支持其在传统医学中的潜在应用。进一步的研究应深入探讨棘叶提取物在解决肥胖和微生物感染方面的多种应用和机制。本研究对棘豆芽提取物进行了综合评价，重点关注其抗氧化和抗菌特性，这些特性在肥胖管理方面尚未得到广泛研究。

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引用次数: 0

High-efficiency multi-band metamaterial absorber for X to Ka band applications 用于X到Ka波段应用的高效多波段超材料吸收体

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science

Pub Date : 2025-11-19 DOI: 10.1016/j.kjs.2025.100514

Khalid Saeed Lateef Al-Badri

We propose an advanced Perfect Metamaterial Absorber for Microwave Band (PMAMB) featuring a unique Y-shaped resonator design, specifically suitable for multi-frequency PMAMB across the X, Ku, K, and Ka bands. Constructed on an FR4 substrate, this PMAMB demonstrates exceptional perfect absorption, independent of polarization angle, and angular stability. The design realizes strong absorption peaks at four distinct frequencies: 10.28 GHz, 16.56 GHz, 22.74 GHz, and 25.96 GHz with absorption rates of 95.7 %, 97.3 %, 99.8 %, and 97.1 %, respectively, as confirmed through detailed simulation analysis. The evolution of the design, progressing through three resonator designs (1, 2, and 3), highlights how structural simplicity can significantly enhance performance. This PMAMB outperforms the existing structure in both multi-microwave band functionality and efficiency. Its versatility makes it highly appropriate for applications such as electromagnetic interference shielding (EMI), radar systems, and advanced wireless communication technologies.

我们提出了一种先进的微波波段完美超材料吸收器（PMAMB），具有独特的y形谐振器设计，特别适用于X， Ku， K和Ka波段的多频PMAMB。在FR4衬底上构建，该PMAMB具有出色的完美吸收，独立于偏振角和角稳定性。通过详细的仿真分析，该设计在10.28 GHz、16.56 GHz、22.74 GHz和25.96 GHz四个不同频率处实现了强吸收峰，其吸收率分别为95.7%、97.3%、99.8%和97.1%。设计的演变，通过三种谐振器设计（1、2和3），突出了结构的简单性如何显著提高性能。该PMAMB在多微波波段功能和效率方面都优于现有结构。它的多功能性使其非常适用于电磁干扰屏蔽（EMI）、雷达系统和先进的无线通信技术等应用。

引用次数: 0

On q-Pell sequence spaces: A study of operator ideals and geometric properties 关于q-Pell序列空间：算子理想及其几何性质的研究

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science

Pub Date : 2025-11-15 DOI: 10.1016/j.kjs.2025.100512

Shiva Shah, Bipan Hazarika

<div><div>The matrix <span><math><mrow><mi>P</mi><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>=</mo><msub><mrow><mrow><mo>{</mo><msub><mrow><mi>Ψ</mi></mrow><mrow><mi>λ</mi><mi>μ</mi></mrow></msub><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>}</mo></mrow></mrow><mrow><mi>λ</mi><mo>,</mo><mi>μ</mi><mo>∈</mo><mi>N</mi></mrow></msub></mrow></math></span>, called the <span><math><mi>q</mi></math></span>-Pell matrix, with elements determined by <span><span><span><math><mrow><mi>P</mi><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>=</mo><mfenced><mrow><mtable><mtr><mtd><mfrac><mrow><mn>2</mn><mspace></mspace><msup><mrow><mi>q</mi></mrow><mrow><mi>μ</mi><mo>−</mo><mn>1</mn></mrow></msup><mspace></mspace><msub><mrow><mi>Ψ</mi></mrow><mrow><mi>μ</mi></mrow></msub><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow></mrow><mrow><msub><mrow><mi>Ψ</mi></mrow><mrow><mi>λ</mi><mo>+</mo><mn>1</mn></mrow></msub><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>+</mo><msub><mrow><mi>Ψ</mi></mrow><mrow><mi>λ</mi></mrow></msub><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>−</mo><mn>1</mn></mrow></mfrac><mo>,</mo><mspace></mspace></mtd><mtd><mtext>if</mtext><mn>1</mn><mo>≤</mo><mi>μ</mi><mo>≤</mo><mi>λ</mi><mo>,</mo></mtd></mtr><mtr><mtd><mn>0</mn><mo>,</mo><mspace></mspace></mtd><mtd><mtext>if</mtext><mi>μ</mi><mo>></mo><mi>λ</mi><mo>.</mo></mtd></mtr></mtable></mrow></mfenced></mrow></math></span></span></span>with <span><math><mrow><mo>{</mo><msub><mrow><mi>Ψ</mi></mrow><mrow><mi>λ</mi></mrow></msub><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>}</mo></mrow></math></span> representing the <span><math><mi>q</mi></math></span>-Pell sequence. Using <span><math><mrow><mi>P</mi><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow></mrow></math></span> is defined by <span><span><span><math><mrow><msub><mrow><mi>Ψ</mi></mrow><mrow><mi>λ</mi></mrow></msub><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>=</mo><mrow><mo>(</mo><mn>1</mn><mo>+</mo><msup><mrow><mi>q</mi></mrow><mrow><mi>λ</mi><mo>+</mo><mn>1</mn></mrow></msup><mo>)</mo></mrow><msub><mrow><mi>Ψ</mi></mrow><mrow><mi>λ</mi><mo>−</mo><mn>1</mn></mrow></msub><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>+</mo><msub><mrow><mi>Ψ</mi></mrow><mrow><mi>λ</mi><mo>−</mo><mn>2</mn></mrow></msub><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow></mrow></math></span></span></span>for <span><math><mrow><mi>λ</mi><mo>≥</mo><mn>2</mn></mrow></math></span>, <span><math><mrow><msub><mrow><mi>Ψ</mi></mrow><mrow><mn>0</mn></mrow></msub><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>=</mo><mn>0</mn><mo>,</mo><msub><mrow><mi>Ψ</mi></mrow><mrow><mn>1</mn></mrow></msub><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>=</mo><mn>1</mn></mrow></math></span>. In this context, the Schauder basis is derived for the space <span><math><mrow><msub><mrow><mi>ℓ</mi></mrow><mrow><mi>p</mi></mrow></msub><mrow><mo>(</mo><mi>P</mi><mrow><mo>(</mo><mi>q</mi><mo>)</mo></mrow><mo>)</mo></mrow></mrow></math></span> for <span><math><mrow><mn>1</mn><mo>≤</mo><mi>p</mi><mo>≤</m

矩阵P (q) ={Ψλμ(q)}λ,μ∈N,称为q-Pell矩阵,与元素由P (q) = 2μ−1Ψμ(q)Ψλ+ 1 (q) +Ψλ(q)−1,i≤μ≤λ,0,如果μ祝辞λ。其中{Ψλ(q)}表示q- pell序列。使用P (q)被定义为Ψλ(q) = (1 + qλ+ 1)Ψλ−1 (q) +Ψλ−2 (q)λ≥2,Ψ0 (q) = 0,Ψ1 (q) = 1。在这种情况下，导出了1≤p≤∞时空间p（p(q)）的Schauder基。研究了l_p （p(q)）和l_∞(p(q))的关键几何性质，如近似性质、Dunford-Pettis性质、Hahn-Banach扩展性质和圆度。最后，研究了这些序列空间的固性性质。

引用次数: 0

Optimizing neutron-gamma discrimination in scintillation detectors using Tucker decomposition 利用Tucker分解优化闪烁探测器中中子-伽马识别

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science

Pub Date : 2025-11-10 DOI: 10.1016/j.kjs.2025.100511

Imane Ahnouz , Hanan Arahmane , Rajaa Sebihi

Neutron-gamma discrimination is essential for applications in radiation monitoring and nuclear safety. Conventional methods often face challenges related to complex signal processing and experimental constraints. This study presents fast and accurate methods for signal separation based on multiway blind source separation (MBSS) and sequentially truncated multilinear singular value decomposition (ST-MLSVD), both leveraging Tucker decomposition. These methods are applied to mixed signals acquired from scintillator detectors and evaluated using the fit parameter, mean signal-to-interference ratio (meanSIR), and correlation coefficients for source characterization. Results show that meanSIR values for the first two modes range from

189.3083 dB

to

270.0128 dB

, and from

63.3614 dB

to

119.1609 dB

for the third mode. Correlation coefficients between each mode component and pure neutron or gamma reference signals range from

0.66

and

0.99

, indicating strong signal alignment. Both MBSS and ST-MLSVD demonstrate high discrimination performance, with ST-MLSVD notably offering improved computational efficiency. To further validate the separation quality, K-means clustering was employed, and the figure of merit (FOM) was computed for each method, yielding FOM values

\geq 3.17

. These findings highlight the reliability and effectiveness of the proposed approaches in neutron–gamma signal discrimination.

中子- γ鉴别对于辐射监测和核安全的应用至关重要。传统的方法经常面临复杂的信号处理和实验限制的挑战。本研究提出了基于多路盲源分离（MBSS）和顺序截断多线性奇异值分解（ST-MLSVD）的快速、准确的信号分离方法，两者均利用Tucker分解。这些方法应用于从闪烁体探测器获取的混合信号，并使用拟合参数、平均信干涉比（meanSIR）和源表征的相关系数进行评估。结果表明，前两种模式的平均sir值在189.3083 ~ 270.0128dB之间，第三种模式的平均sir值在63.3614 ~ 119.1609dB之间。各模分量与纯中子或伽马参考信号的相关系数在0.66 ~ 0.99之间，表明信号对准性强。MBSS和ST-MLSVD均表现出较高的识别性能，其中ST-MLSVD的计算效率显著提高。为了进一步验证分离质量，采用K-means聚类，并计算每种方法的优值（FOM），得到FOM值≥3.17。这些发现突出了所提出的中子-伽马信号鉴别方法的可靠性和有效性。

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引用次数: 0

Multifunctional properties of Thai vegetable extracts: Inhibition of foodborne pathogens, anti-inflammatory activity, and anti-apoptotic effects 泰国蔬菜提取物的多功能特性：抑制食源性病原体，抗炎活性和抗凋亡作用

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science

Pub Date : 2025-11-07 DOI: 10.1016/j.kjs.2025.100510

Adisak Palasap , Patcharee Boonsiri , Nisachon Jangpromma , Sakda Daduang , Narintorn Rattanata , Daraporn Chua-on , Patcharaporn Tippayawat , Pornsuda Maraming , Ratree Tavichakorntrakool , Pitsamai Saisud , Jringjai Areemit , Jureerut Daduang

Foodborne pathogens represent a significant global health challenge. Vegetables, rich in phytochemicals, offer the potential to inhibit these pathogens. This study investigated the therapeutic potential of ethanolic extracts from eight local Thai vegetables against common foodborne bacteria and inflammation. Antibacterial properties were evaluated using disk-diffusion and minimum bactericidal concentration (MBC) assays against Staphylococcus aureus, Escherichia coli, Salmonella spp., Vibrio cholerae, and Shigella flexneri. Anti-inflammation and anti-apoptosis effects were also evaluated. All extracts demonstrated antibacterial activity, with Schinus terebinthifolius Raddi (MT) and Caesalpinia mimosoides Lamk (KY) showing particularly potent effects. The scanning electron microscope revealed that MT and KY extracts disrupted bacterial cell walls. Additionally, MT, KY, Zanthoxylum limonella Alston (MK), and Acmella oleracea (L.) R.K. Jansen (KV) significantly reduced nitric oxide production in lipopolysaccharide (LPS)-treated RAW 264.7 cells. Real-time polymerase chain reaction (PCR) analysis indicated that these extracts significantly downregulated the expression of iNOS, TNF-α, IL-1β, IL-6, caspase-3, and p53 mRNA. Our findings suggest that these vegetable extracts have potential for further development as therapeutic agents against foodborne pathogens and related inflammation.

食源性病原体是一项重大的全球卫生挑战。蔬菜富含植物化学物质，有可能抑制这些病原体。本研究调查了泰国当地八种蔬菜的乙醇提取物对常见食源性细菌和炎症的治疗潜力。采用圆盘扩散法和最低杀菌浓度（MBC）法对金黄色葡萄球菌、大肠杆菌、沙门氏菌、霍乱弧菌和福氏志贺氏菌进行抑菌性能评价。并对其抗炎症和抗细胞凋亡作用进行了评价。所有提取物均表现出抑菌活性，其中三叶草（Schinus terebinthifolius Raddi， MT）和三叶草（Caesalpinia mimosoides Lamk， KY）表现出特别强的抑菌作用。扫描电镜显示，MT和KY提取物破坏了细菌细胞壁。此外，MT， KY，花椒柠檬Alston （MK）和Acmella oleracea （L.）R.K. Jansen （KV）显著降低脂多糖（LPS）处理的RAW 264.7细胞中一氧化氮的产生。实时聚合酶链反应（Real-time polymerase chain reaction， PCR）结果显示，这些提取物显著下调了iNOS、TNF-α、IL-1β、IL-6、caspase-3和p53 mRNA的表达。我们的研究结果表明，这些植物提取物作为食源性病原体和相关炎症的治疗剂具有进一步开发的潜力。

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引用次数: 0

Antidiabetic, antioxidant, and anti-inflammatory activities of Paronychia capitata L. and Paronychia argentea L. from Algerian medicinal plants and identification of its bioactive compounds by LC-MS/MS phytochemical analysis 阿尔及利亚药用植物首甲甲鱼（Paronychia capitata L.）和银甲鱼（Paronychia argentea L.）的抗糖尿病、抗氧化和抗炎活性及其生物活性成分的LC-MS/MS分析

IF 1.1 4区综合性期刊 Q3 MULTIDISCIPLINARY SCIENCES

Kuwait Journal of Science

Pub Date : 2025-10-22 DOI: 10.1016/j.kjs.2025.100509

Ahlem Karbab , Noureddine Charef , Andika Pramudya Wardana , Muhammad Ikhlas Abdjan , Ashok K. Shakya , Nanik Siti Aminah

Paronychia capitata L. (PC) and Paronychia argentea L. (PA) are traditionally used in Algerian folk medicine to treat various ailments, including urolithiasis, diabetes, bladder disorders, and gastric ulcers. This study aimed to evaluate the phytochemical composition, antidiabetic, antioxidant, and anti-inflammatory activities, as well as the acute oral toxicity of aqueous and ethanol extracts from both species. Qualitative phytochemical screening confirmed the presence of polyphenols, flavonoids, tannins, and sugars in the extracts. Quantitative assays were preformed to determine the total phenol and total flavonoids contents. At the same time, results from LC-MS/MS analysis revealed the presence of ascorbic acid and phenolic substances including quercetin, and other phenolic and flavonoid components in the extracts. In vitro antidiabetic activity, assessed via α-glucosidase inhibition, revealed potent effects of P. argentea aqueous and ethanolic extracts, with an IC₅₀ values of 20.62 ± 3.60 μg/mL and 26.90 ± 3.34 μg/mL, respectively. All extracts demonstrated strong antioxidant activity. In vitro anti-inflammatory activity, evaluated through protein denaturation inhibition, showed substantial effects for all extracts. In vivo anti-inflammatory activity, as assessed using the xylene-induced ear edema model, demonstrated significant inhibition by ethanol extracts of both species, with P. capitata (PCEE) and P. argentea (PAEE) exhibiting 79.01 ± 3.52 % and 79.94 ± 4.63 % inhibition, respectively. Acute oral toxicity tests indicated that the extracts were safe up to 2 g/kg body weight, with no observed mortality or behavioral changes in mice. These findings support the ethnomedicinal use of Paronychia species and highlight their potential as sources of bioactive compounds for therapeutic applications.

甲甲鱼（PC）和阿根廷甲甲鱼（PA）传统上在阿尔及利亚民间医学中用于治疗各种疾病，包括尿石症、糖尿病、膀胱疾病和胃溃疡。本研究旨在评估这两种植物的植物化学成分、抗糖尿病、抗氧化和抗炎活性，以及水提取物和乙醇提取物的急性口服毒性。定性植物化学筛选证实了提取物中存在多酚、类黄酮、单宁和糖。定量测定了总酚和总黄酮的含量。同时，LC-MS/MS分析结果显示，提取物中含有抗坏血酸和槲皮素等酚类物质，以及其他酚类和类黄酮成分。体外抗糖尿病活性通过α-葡萄糖苷酶抑制测定，结果表明银青茶水提液和醇提液的IC50值分别为20.62±3.60 μg/mL和26.90±3.34 μg/mL。所有提取物均表现出较强的抗氧化活性。体外抗炎活性，通过评估蛋白质变性抑制，显示出实质性的影响，所有提取物。用二甲苯诱导的耳部水肿模型评估了两种植物的体内抗炎活性，结果表明，两种植物的乙醇提取物均具有显著的抑制作用，其中，头叶大蠊（PCEE）和银茶大蠊（PAEE）的抑制作用分别为79.01±3.52%和79.94±4.63%。急性口服毒性试验表明，提取物在每公斤体重达到2克时是安全的，在小鼠中没有观察到死亡或行为改变。这些发现支持了甲鱼的民族医学用途，并突出了其作为治疗应用的生物活性化合物来源的潜力。

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