Wastewater treatment from industrial effluents is a global problem. Searching for environmentally safe and green technology is in the utmost interest of the scientific community. Especially organic pollutants, due to their difficulty to biodegrade, have posed a problem to human health and the aquatic environment. Hence, we reported plant extract-mediated synthesis of zinc oxide nanoparticles (ZnO NPs) in this study for photocatalytic degradation of methylene blue (MB) under sunlight irradiation. Echinops kebericho root extract was used as a reducing and stabilizing agent during the synthesis of ZnO NPs. The presence of phenolics, tannins, flavonoids, terpenoids, and alkaloids was qualitatively confirmed in the aqueous root extract of the plant under study. These secondary metabolites have a high potential in facilitating capping and stabilizing effects on the formation of ZnO nanostructures. Powder X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy were used to characterize the crystal structure and chemical bond of ZnO NPs, respectively. The XRD patterns showed the formation of pure phase hexagonal wurtzite ZnO NPs with an average crystal size of 14.67 nm. The photocatalytic degradation efficiency of ZnO NPs (80 mg) to remove 10 mg/L of MB dye was found to be 92.2% at pH=10 and 120 min contact time under direct sunlight irradiation. Therefore, ZnO NPs synthesized using E.kebericho were potential photocatalysts for the degradation of MB from wastewater for at least three cycles.
{"title":"Echinops kebericho Aqueous Root Extract Assisted Green Synthesis of Zinc Oxide Nanoparticles for Photocatalytic Degradation of Methylene Blue","authors":"","doi":"10.33263/lianbs123.072","DOIUrl":"https://doi.org/10.33263/lianbs123.072","url":null,"abstract":"Wastewater treatment from industrial effluents is a global problem. Searching for environmentally safe and green technology is in the utmost interest of the scientific community. Especially organic pollutants, due to their difficulty to biodegrade, have posed a problem to human health and the aquatic environment. Hence, we reported plant extract-mediated synthesis of zinc oxide nanoparticles (ZnO NPs) in this study for photocatalytic degradation of methylene blue (MB) under sunlight irradiation. Echinops kebericho root extract was used as a reducing and stabilizing agent during the synthesis of ZnO NPs. The presence of phenolics, tannins, flavonoids, terpenoids, and alkaloids was qualitatively confirmed in the aqueous root extract of the plant under study. These secondary metabolites have a high potential in facilitating capping and stabilizing effects on the formation of ZnO nanostructures. Powder X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy were used to characterize the crystal structure and chemical bond of ZnO NPs, respectively. The XRD patterns showed the formation of pure phase hexagonal wurtzite ZnO NPs with an average crystal size of 14.67 nm. The photocatalytic degradation efficiency of ZnO NPs (80 mg) to remove 10 mg/L of MB dye was found to be 92.2% at pH=10 and 120 min contact time under direct sunlight irradiation. Therefore, ZnO NPs synthesized using E.kebericho were potential photocatalysts for the degradation of MB from wastewater for at least three cycles.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82979495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The exploration of new materials as well as methods and sources of their production is a constantly growing trend in both scientific and industrial directions. One such method is carbonization, which has attracted a lot of attention over the past decades. Carbonization is the process of preparation of 3D carbonaceous materials with unique properties by thermal treatments with the exclusion of oxygen. A higher specific surface area characterizes the obtained nanoporous carbon materials compared to their precursors, and, consequently, they can be used in such fields as biotechnology, electrochemistry, or electronic industry. Special attention has been directed to the carbonization of nanoorganized biological materials due to their extensive composition and unique hierarchical structure. This review aims to provide insight into the examples of carbonization of selected biomaterials such as polysaccharides (cellulose, chitin) and proteins (keratin, spongin, silk) evidenced by excellent and successful examples from the recent literature. In addition, this work highlights the most significant aspects of diverse experiments, allowing getting inspiration for fields such as materials science and well extreme biomimetics.
{"title":"Carbonization of Selected Biological Materials, Trends, and Perspectives","authors":"","doi":"10.33263/lianbs123.068","DOIUrl":"https://doi.org/10.33263/lianbs123.068","url":null,"abstract":"The exploration of new materials as well as methods and sources of their production is a constantly growing trend in both scientific and industrial directions. One such method is carbonization, which has attracted a lot of attention over the past decades. Carbonization is the process of preparation of 3D carbonaceous materials with unique properties by thermal treatments with the exclusion of oxygen. A higher specific surface area characterizes the obtained nanoporous carbon materials compared to their precursors, and, consequently, they can be used in such fields as biotechnology, electrochemistry, or electronic industry. Special attention has been directed to the carbonization of nanoorganized biological materials due to their extensive composition and unique hierarchical structure. This review aims to provide insight into the examples of carbonization of selected biomaterials such as polysaccharides (cellulose, chitin) and proteins (keratin, spongin, silk) evidenced by excellent and successful examples from the recent literature. In addition, this work highlights the most significant aspects of diverse experiments, allowing getting inspiration for fields such as materials science and well extreme biomimetics.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77196411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this work, we have studied the geometric structure and electronic and optical properties of Cu2ZnSn(S1-xSex)4 nanocrystals where x = 0, 0.25, 0.50, 0.75, 1.00 by the quantum-chemical calculations within the framework of DFT. For the electronic and optical properties calculations, the effective XC functional and the TB-mBJ potential were used. The calculated structural characteristics show that the volume of these systems increases with increasing the Se concentration. The electronic properties of the Se-doped kesterite Cu2ZnSnS4 show that the bandgap tends to decrease. It was found that the Se-doped material has noticeably increased its absorption capacity. Hence, the efficiency of the Cu2ZnSnS4 in the IR region of radiation improves. The effective reduction bandgap from 1.455 eV to 0.94 eV is observed, which is in gоod agreement with known experimental data for the pure and undoped systems Cu2ZnSnS4 and Cu2ZnSnSе4. The calculated band gap is 1.346 eV for the Cu2ZnSnS3Se system, which is comparable with the optimal bandgap of semiconductors used in photovoltaic applications. It was found that with the increase of the Se concentration, the absorption coefficient increases, thereby resulting in the materials' reflectivity decrease. The calculated optoelectronic parameters and the density of electronic states indicate that the Cu2ZnSnS4:Se system possesses a favorable property, suitable for applications in solar cells technology.
{"title":"A DFT Study of Structure, Electronic and Optical Properties of Se-Doped Kesterite Cu2ZnSnS4 (CZTSSe)","authors":"","doi":"10.33263/lianbs123.067","DOIUrl":"https://doi.org/10.33263/lianbs123.067","url":null,"abstract":"In this work, we have studied the geometric structure and electronic and optical properties of Cu2ZnSn(S1-xSex)4 nanocrystals where x = 0, 0.25, 0.50, 0.75, 1.00 by the quantum-chemical calculations within the framework of DFT. For the electronic and optical properties calculations, the effective XC functional and the TB-mBJ potential were used. The calculated structural characteristics show that the volume of these systems increases with increasing the Se concentration. The electronic properties of the Se-doped kesterite Cu2ZnSnS4 show that the bandgap tends to decrease. It was found that the Se-doped material has noticeably increased its absorption capacity. Hence, the efficiency of the Cu2ZnSnS4 in the IR region of radiation improves. The effective reduction bandgap from 1.455 eV to 0.94 eV is observed, which is in gоod agreement with known experimental data for the pure and undoped systems Cu2ZnSnS4 and Cu2ZnSnSе4. The calculated band gap is 1.346 eV for the Cu2ZnSnS3Se system, which is comparable with the optimal bandgap of semiconductors used in photovoltaic applications. It was found that with the increase of the Se concentration, the absorption coefficient increases, thereby resulting in the materials' reflectivity decrease. The calculated optoelectronic parameters and the density of electronic states indicate that the Cu2ZnSnS4:Se system possesses a favorable property, suitable for applications in solar cells technology.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"94 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91300531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
(HEC/SA/HA/AgNP hydrogels) were successfully prepared using Hyaluronic acid (HA), Sodium alginate (SA), Hydroxyethylcellulose (HEC, and Silver nanoparticles (AgNPs). HEC/SA/HA/AgNP hydrogels were cross-linked via Ca2+ ions. The structural, chemical and physical properties of the hydrogel have been studied, which include: swelling ratio, antibacterial and antifungal activity, and also UV-Vis, FTIR, SEM, EDX after making sponges via the freeze-drying technique. The characteristic peak of UV-Vis spectra revealed the formation of AgNPs in the compound at 411 nm. The FTIR curves showed new peaks that confirmed the oxidation of HEC, and showed the chemical interaction of the three polymers with AgNPs and Ca2+. The SEM images showed monodispersed AgNPs with a size ranging (from 8.2 to 32 nm ). The results from these studies showed that the hydrogel has an excellent performance in swelling ratio. Furthermore, the hydrogel activity against bacteria and fungi was also measured for 72 h, and the results showed that these hydrogels were more effective against the microbes. These results suggested that the crosslinked hydrogel (HEC/HA/SA) with AgNPs might be an excellent dressing for wounds.
{"title":"Novel Antibacterial Wound Healing Hydrogels Based On HEC/SA/HA Using Green Chemistry Approach","authors":"","doi":"10.33263/lianbs123.069","DOIUrl":"https://doi.org/10.33263/lianbs123.069","url":null,"abstract":"(HEC/SA/HA/AgNP hydrogels) were successfully prepared using Hyaluronic acid (HA), Sodium alginate (SA), Hydroxyethylcellulose (HEC, and Silver nanoparticles (AgNPs). HEC/SA/HA/AgNP hydrogels were cross-linked via Ca2+ ions. The structural, chemical and physical properties of the hydrogel have been studied, which include: swelling ratio, antibacterial and antifungal activity, and also UV-Vis, FTIR, SEM, EDX after making sponges via the freeze-drying technique. The characteristic peak of UV-Vis spectra revealed the formation of AgNPs in the compound at 411 nm. The FTIR curves showed new peaks that confirmed the oxidation of HEC, and showed the chemical interaction of the three polymers with AgNPs and Ca2+. The SEM images showed monodispersed AgNPs with a size ranging (from 8.2 to 32 nm ). The results from these studies showed that the hydrogel has an excellent performance in swelling ratio. Furthermore, the hydrogel activity against bacteria and fungi was also measured for 72 h, and the results showed that these hydrogels were more effective against the microbes. These results suggested that the crosslinked hydrogel (HEC/HA/SA) with AgNPs might be an excellent dressing for wounds.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"187 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86313557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this report, Polylactide/Nanoclay/TiO2 nanocomposite films with two different weight percentages (2wt% and 5wt %) of clay and TiO2 nanoparticles were prepared by a cost-effective approach. A solvent casting process with the help of a cost-effective film applicator was used to prepare nanocomposite films. The surface morphology investigations revealed the agglomeration of fillers at higher weight percentages and uniform mixing of fillers at lower weight percentages. The crystallinity of the prepared films did not alter much with the nanofiller addition. Nanofillers with a 2wt% concentration in the PLA matrix enhanced thermal and mechanical properties significantly. The PLA nanocomposite films have exhibited an intense broad emission band in violet color with a wavelength of ≈420 nm. In addition, the antibacterial activity of polylactic acid nanocomposite films was investigated against Gram-positive S. aureus and Gram-negative E. coli bacteria. The enhanced antibacterial activity is observed for a 5wt% concentration of nanofillers. The results showed that the antibacterial activity increases with nanofiller concentration. This study presents a simple and cost-effective approach to preparing nanocomposite films with tuneable properties of mechanical, thermal, and antibacterial activity.
{"title":"Structural, Thermal, Optical, Mechanical, and Antibacterial Properties of PLA/Nanoclay/TiO2 Nanocomposite Films","authors":"","doi":"10.33263/lianbs123.070","DOIUrl":"https://doi.org/10.33263/lianbs123.070","url":null,"abstract":"In this report, Polylactide/Nanoclay/TiO2 nanocomposite films with two different weight percentages (2wt% and 5wt %) of clay and TiO2 nanoparticles were prepared by a cost-effective approach. A solvent casting process with the help of a cost-effective film applicator was used to prepare nanocomposite films. The surface morphology investigations revealed the agglomeration of fillers at higher weight percentages and uniform mixing of fillers at lower weight percentages. The crystallinity of the prepared films did not alter much with the nanofiller addition. Nanofillers with a 2wt% concentration in the PLA matrix enhanced thermal and mechanical properties significantly. The PLA nanocomposite films have exhibited an intense broad emission band in violet color with a wavelength of ≈420 nm. In addition, the antibacterial activity of polylactic acid nanocomposite films was investigated against Gram-positive S. aureus and Gram-negative E. coli bacteria. The enhanced antibacterial activity is observed for a 5wt% concentration of nanofillers. The results showed that the antibacterial activity increases with nanofiller concentration. This study presents a simple and cost-effective approach to preparing nanocomposite films with tuneable properties of mechanical, thermal, and antibacterial activity.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81590614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Synthesis of aminopyrimidine derivatives was carried out by microwave synthesis. This microwave-assisted heating is an eco-friendly method. Aminopyrimidines were modified by using substituted benzaldehydes, acetophenones, and uracil during synthesis. Compounds were screened pharmacologically against the cancer cell lines. To synthesize the uracil substituted amino pyrimidines involving aldol condensation. The Invitro cytotoxicity studies against the cancer cell lines using MTT assay and the antimicrobial resistance using the bacterial and fungal strains. Aminopyrimidines were synthesized by condensation of chalcones and guanidine and further substituted with uracil. These aminopyrimidine derivatives were analyzed by FT-IR, 1H NMR, and MASS spectra. Compounds were evaluated for cytotoxicity studies against the HeLa and Vero cancer cell lines using an MTT assay. Antibacterial and antifungal activity by cup plate and two-fold serial dilution method was done. Substituted amino pyrimidines were synthesized by microwave-assisted heating and yielded in the range of 33-56%. Melting point, solubility, and spectral analysis were carried out. All the compounds exhibited no cytotoxicity. The compounds C7, C9, and C12 were viable the most at the concentration of 625µg/ml against HeLa and Vero cell lines. The compound C10 showed the highest zone of inhibition against the bacteria Mycobacterium phlei, Bacillus cereus, and Escherichia coli by both cup plate and serial dilution methods. It exhibited more inhibition against the fungi Aspergillus niger than the bacteria. The compounds with nitro substituted were found to be more effective than any other substitution. The aminopyrimidine derivatives synthesized by microwave procedure were evaluated for antimicrobial screening. It resulted in similar inhibition as ciprofloxacin. This work would serve the researchers for the eco-friendly method of synthesis and screening drugs for antimicrobial activity.
{"title":"Microwave-Assisted One-Pot Synthesis of Aminopyrimidine Scaffolds and their Biological Evaluation","authors":"","doi":"10.33263/lianbs123.063","DOIUrl":"https://doi.org/10.33263/lianbs123.063","url":null,"abstract":"Synthesis of aminopyrimidine derivatives was carried out by microwave synthesis. This microwave-assisted heating is an eco-friendly method. Aminopyrimidines were modified by using substituted benzaldehydes, acetophenones, and uracil during synthesis. Compounds were screened pharmacologically against the cancer cell lines. To synthesize the uracil substituted amino pyrimidines involving aldol condensation. The Invitro cytotoxicity studies against the cancer cell lines using MTT assay and the antimicrobial resistance using the bacterial and fungal strains. Aminopyrimidines were synthesized by condensation of chalcones and guanidine and further substituted with uracil. These aminopyrimidine derivatives were analyzed by FT-IR, 1H NMR, and MASS spectra. Compounds were evaluated for cytotoxicity studies against the HeLa and Vero cancer cell lines using an MTT assay. Antibacterial and antifungal activity by cup plate and two-fold serial dilution method was done. Substituted amino pyrimidines were synthesized by microwave-assisted heating and yielded in the range of 33-56%. Melting point, solubility, and spectral analysis were carried out. All the compounds exhibited no cytotoxicity. The compounds C7, C9, and C12 were viable the most at the concentration of 625µg/ml against HeLa and Vero cell lines. The compound C10 showed the highest zone of inhibition against the bacteria Mycobacterium phlei, Bacillus cereus, and Escherichia coli by both cup plate and serial dilution methods. It exhibited more inhibition against the fungi Aspergillus niger than the bacteria. The compounds with nitro substituted were found to be more effective than any other substitution. The aminopyrimidine derivatives synthesized by microwave procedure were evaluated for antimicrobial screening. It resulted in similar inhibition as ciprofloxacin. This work would serve the researchers for the eco-friendly method of synthesis and screening drugs for antimicrobial activity.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79046753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Thal Desert in Punjab, Pakistan, is known for being home to a number of plants, many of which are utilized by the local natural healers to treat various inflammatory and non-inflammatory conditions. However, no scientific studies to date have evaluated these plant-based therapeutics. Here we report on the results of an antipyretic study of two plants from the Thal Desert, namely Fagonia bruguieri and Tamarix dioica, in an animal model. Hydro-alcoholic extracts of the two plants were tested for their ability to reduce pyrexia induced by Escherichia coli in rabbits. Rabbits were divided into five separate groups for each plant extract tested, numbering five animals each. They included a negative control group where animals were subjected to no treatment and a positive control group subjected to the conventional treatment with 150 mg/kg paracetamol. Animals comprising the additional three sample groups were treated with 100, 250, and 500 mg/kg of the experimental medicines in the form of hydro-ethanol concentrates of Fagonia bruguieri and Tamarix dioica. The treatment with the plant concentrates showed a highly positive antipyretic effect relative to both controls in these animal trials. The average body temperatures of the animals 5 h after the treatment with either Tamarix dioica or Fagonia bruguieri were significantly (p < 0.05) lower than those in both control groups. The differences were not as significant at lower time points, suggesting that the plant extracts exhibit slower pharmacokinetics and have a stronger and longer-lasting effect than the conventional treatment. Another insight emerging from this study is that the hydro-ethanol concentrates of the plants assessed in this examination exhibit a dose-dependent antipyretic effect. The antipyretic activity of Fagonia bruguieri and Tamarix dioica is pronounced in an animal model. Further investigations of these plant species emerge as imperative from this study.
{"title":"Antipyretic Activity of Medicinal Plants from the Thal Desert","authors":"","doi":"10.33263/lianbs123.062","DOIUrl":"https://doi.org/10.33263/lianbs123.062","url":null,"abstract":"The Thal Desert in Punjab, Pakistan, is known for being home to a number of plants, many of which are utilized by the local natural healers to treat various inflammatory and non-inflammatory conditions. However, no scientific studies to date have evaluated these plant-based therapeutics. Here we report on the results of an antipyretic study of two plants from the Thal Desert, namely Fagonia bruguieri and Tamarix dioica, in an animal model. Hydro-alcoholic extracts of the two plants were tested for their ability to reduce pyrexia induced by Escherichia coli in rabbits. Rabbits were divided into five separate groups for each plant extract tested, numbering five animals each. They included a negative control group where animals were subjected to no treatment and a positive control group subjected to the conventional treatment with 150 mg/kg paracetamol. Animals comprising the additional three sample groups were treated with 100, 250, and 500 mg/kg of the experimental medicines in the form of hydro-ethanol concentrates of Fagonia bruguieri and Tamarix dioica. The treatment with the plant concentrates showed a highly positive antipyretic effect relative to both controls in these animal trials. The average body temperatures of the animals 5 h after the treatment with either Tamarix dioica or Fagonia bruguieri were significantly (p < 0.05) lower than those in both control groups. The differences were not as significant at lower time points, suggesting that the plant extracts exhibit slower pharmacokinetics and have a stronger and longer-lasting effect than the conventional treatment. Another insight emerging from this study is that the hydro-ethanol concentrates of the plants assessed in this examination exhibit a dose-dependent antipyretic effect. The antipyretic activity of Fagonia bruguieri and Tamarix dioica is pronounced in an animal model. Further investigations of these plant species emerge as imperative from this study.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"532 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91462982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JAB1 or C-Jun activation domain-binding protein-1 plays a role in controlling cellular proliferation, cell apoptosis, cell cycle, and regulating genomic instability as well as DNA damage response. JAB1 dysregulation contributes to oncogenesis via deactivating tumor suppressor genes. Vitis vinifera, Tabernaemontana corymbosa, and Aloe vera have been known for their antitumor functions. However, the inhibitory role of phytocompounds derived from Vitis vinifera, Tabernaemontana corymbosa, and Aloe barbadensis miller (Aloe vera) against JAB1 has not yet been elucidated. Therefore, we studied the naturally derived compounds from Vitis vinifera, Tabernaemontana corymbosa, and Aloe vera, which can interact and decrease the activities of JAB1 using in-silico analysis. Eighty-one compounds were screened using PyRx and further analyzed via Lipinski's rule. Further, on executing molecular docking studies on the sixty selected compounds, Iboluteine was found to be a potent inhibitor of JAB1 and should further be explored in in-vitro studies to substantiate these assertions. Phytocompounds are a reservoir of bioactive molecules that can be particularly useful in treating cervical cancer due to their limited toxicity and amenability from the development of drug resistance. Thus, this study aims to identify possible naturally derived compounds from Vitis vinifera, Tabernaemontana corymbosa, and Aloe vera, which can selectively decrease the activities of JAB1 that has the potential to be a crucial anti-cancer therapeutic molecule against cervical cancer.
{"title":"Evaluation of Phytocompounds of Vitis vinifera, Tabernaemontana corymbosa and Aloe vera against JAB1: A Strategy to Treat Cervical Cancer","authors":"","doi":"10.33263/lianbs123.066","DOIUrl":"https://doi.org/10.33263/lianbs123.066","url":null,"abstract":"JAB1 or C-Jun activation domain-binding protein-1 plays a role in controlling cellular proliferation, cell apoptosis, cell cycle, and regulating genomic instability as well as DNA damage response. JAB1 dysregulation contributes to oncogenesis via deactivating tumor suppressor genes. Vitis vinifera, Tabernaemontana corymbosa, and Aloe vera have been known for their antitumor functions. However, the inhibitory role of phytocompounds derived from Vitis vinifera, Tabernaemontana corymbosa, and Aloe barbadensis miller (Aloe vera) against JAB1 has not yet been elucidated. Therefore, we studied the naturally derived compounds from Vitis vinifera, Tabernaemontana corymbosa, and Aloe vera, which can interact and decrease the activities of JAB1 using in-silico analysis. Eighty-one compounds were screened using PyRx and further analyzed via Lipinski's rule. Further, on executing molecular docking studies on the sixty selected compounds, Iboluteine was found to be a potent inhibitor of JAB1 and should further be explored in in-vitro studies to substantiate these assertions. Phytocompounds are a reservoir of bioactive molecules that can be particularly useful in treating cervical cancer due to their limited toxicity and amenability from the development of drug resistance. Thus, this study aims to identify possible naturally derived compounds from Vitis vinifera, Tabernaemontana corymbosa, and Aloe vera, which can selectively decrease the activities of JAB1 that has the potential to be a crucial anti-cancer therapeutic molecule against cervical cancer.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"291 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76459627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biofertilizers are a novel technique for Indian agriculture that has the potential to address many of the shortcomings of chemical-based technology. Plant growth-promoting (PGP) traits such as IAA, P-solubilization, ACC deaminase, NH3, HCN, EPS, siderophore synthesis, and biofilm formation have been demonstrated in two salt-tolerant PGPR, BST YS1 42 (Bacillus cereus) and CHR JH203 (Bacillus marisflavi). They are most commonly utilized to make carrier-based compositions. This study aimed to evaluate how different carrier-based formulations of salt-tolerant PGPR performed in seedlings of pea and maize plants. The chosen PGPR was mass replicated in the lab and put into seedlings via a variety of carriers, including charcoal powder, dry pea peel powder, tea leaf powder, hay+2%peptone, and cowdung powder. The influence of bio inoculants on seedling growth of Pisum sativum and Zea mays seedlings was investigated. There was a substantial variation in seedling germination in both pea and maize. The result was different depending on the type of carrier materials utilized in the bioformulation process. The results showed that seedling germination was better with the bioformulation made with charcoal and tea leaf powder. As a result, we believe it might be used to alleviate abiotic stresses in a cost-effective and environmentally friendly manner.
{"title":"Selection of Carrier Materials to Formulate Bioinoculant Package for Promoting Seed Germination","authors":"","doi":"10.33263/lianbs123.065","DOIUrl":"https://doi.org/10.33263/lianbs123.065","url":null,"abstract":"Biofertilizers are a novel technique for Indian agriculture that has the potential to address many of the shortcomings of chemical-based technology. Plant growth-promoting (PGP) traits such as IAA, P-solubilization, ACC deaminase, NH3, HCN, EPS, siderophore synthesis, and biofilm formation have been demonstrated in two salt-tolerant PGPR, BST YS1 42 (Bacillus cereus) and CHR JH203 (Bacillus marisflavi). They are most commonly utilized to make carrier-based compositions. This study aimed to evaluate how different carrier-based formulations of salt-tolerant PGPR performed in seedlings of pea and maize plants. The chosen PGPR was mass replicated in the lab and put into seedlings via a variety of carriers, including charcoal powder, dry pea peel powder, tea leaf powder, hay+2%peptone, and cowdung powder. The influence of bio inoculants on seedling growth of Pisum sativum and Zea mays seedlings was investigated. There was a substantial variation in seedling germination in both pea and maize. The result was different depending on the type of carrier materials utilized in the bioformulation process. The results showed that seedling germination was better with the bioformulation made with charcoal and tea leaf powder. As a result, we believe it might be used to alleviate abiotic stresses in a cost-effective and environmentally friendly manner.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85837230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Since times immemorial, many plant species have been utilized to cure severe diseases. A wide range of diversification has been observed in various medicinal plants, which are indeed able to cure several deadly diseases. The presence of secondary metabolites is a high priority for their medicinal characteristics. This study focused on T. stans (Yellow bells), a shrub that grows profoundly in tropical and sub-tropical regions. Although many studies have been done on the medicinal value of this plant, not much has been done on cancer treatment and nanomedicine. Green synthesized silver nanoparticles are an eco-friendly approach to delivering the drug to the target size. Nano appearance is an add-on advantage of these compounds. Hence, it is emerging in medicine. Colorectal cancer is the fourth deadliest one globally. Hence the synthesized silver nanoparticles of T. stans flower and leaf extracts showed cytotoxically and wound healing properties on colorectal cancer cell lines (HCT 116 and SW 480). Synthesis of silver nanoparticles confirmation is done by Ultra Violet Visible spectrophotometry and Particle size analyzer. All the results showcase the beneficial effects of silver nanoparticles synthesized plant extracts and may be used as a novel medicine in the field of chemotherapy.
{"title":"Green Synthesis of Tecoma stans Flower and Leaf Extracts: Characterization and Anti-Proliferative Activity in Colorectal Cancer Cell Lines","authors":"","doi":"10.33263/lianbs123.061","DOIUrl":"https://doi.org/10.33263/lianbs123.061","url":null,"abstract":"Since times immemorial, many plant species have been utilized to cure severe diseases. A wide range of diversification has been observed in various medicinal plants, which are indeed able to cure several deadly diseases. The presence of secondary metabolites is a high priority for their medicinal characteristics. This study focused on T. stans (Yellow bells), a shrub that grows profoundly in tropical and sub-tropical regions. Although many studies have been done on the medicinal value of this plant, not much has been done on cancer treatment and nanomedicine. Green synthesized silver nanoparticles are an eco-friendly approach to delivering the drug to the target size. Nano appearance is an add-on advantage of these compounds. Hence, it is emerging in medicine. Colorectal cancer is the fourth deadliest one globally. Hence the synthesized silver nanoparticles of T. stans flower and leaf extracts showed cytotoxically and wound healing properties on colorectal cancer cell lines (HCT 116 and SW 480). Synthesis of silver nanoparticles confirmation is done by Ultra Violet Visible spectrophotometry and Particle size analyzer. All the results showcase the beneficial effects of silver nanoparticles synthesized plant extracts and may be used as a novel medicine in the field of chemotherapy.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84799037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}