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Echinops kebericho Aqueous Root Extract Assisted Green Synthesis of Zinc Oxide Nanoparticles for Photocatalytic Degradation of Methylene Blue 水提物辅助绿色合成氧化锌纳米颗粒光催化降解亚甲基蓝
Pub Date : 2022-04-19 DOI: 10.33263/lianbs123.072
Wastewater treatment from industrial effluents is a global problem. Searching for environmentally safe and green technology is in the utmost interest of the scientific community. Especially organic pollutants, due to their difficulty to biodegrade, have posed a problem to human health and the aquatic environment. Hence, we reported plant extract-mediated synthesis of zinc oxide nanoparticles (ZnO NPs) in this study for photocatalytic degradation of methylene blue (MB) under sunlight irradiation. Echinops kebericho root extract was used as a reducing and stabilizing agent during the synthesis of ZnO NPs. The presence of phenolics, tannins, flavonoids, terpenoids, and alkaloids was qualitatively confirmed in the aqueous root extract of the plant under study. These secondary metabolites have a high potential in facilitating capping and stabilizing effects on the formation of ZnO nanostructures. Powder X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy were used to characterize the crystal structure and chemical bond of ZnO NPs, respectively. The XRD patterns showed the formation of pure phase hexagonal wurtzite ZnO NPs with an average crystal size of 14.67 nm. The photocatalytic degradation efficiency of ZnO NPs (80 mg) to remove 10 mg/L of MB dye was found to be 92.2% at pH=10 and 120 min contact time under direct sunlight irradiation. Therefore, ZnO NPs synthesized using E.kebericho were potential photocatalysts for the degradation of MB from wastewater for at least three cycles.
工业废水的处理是一个全球性问题。寻找对环境安全的绿色技术是科学界的最大利益所在。特别是有机污染物,由于其难以生物降解,给人类健康和水生环境带来了问题。因此,我们在本研究中报道了植物提取物介导的氧化锌纳米颗粒(ZnO NPs)在阳光照射下光催化降解亚甲基蓝(MB)。在合成氧化锌纳米粒子的过程中,以松果根提取物为还原剂和稳定剂。定性证实了该植物根水提取物中酚类、单宁类、黄酮类、萜类和生物碱的存在。这些次生代谢物对ZnO纳米结构的形成具有很大的促进封盖和稳定作用。采用粉末x射线衍射(XRD)和傅里叶变换红外光谱(FT-IR)分别表征了ZnO NPs的晶体结构和化学键。XRD谱图显示,制备的ZnO纳米粒子为纯相六方纤锌矿型,平均晶粒尺寸为14.67 nm。当pH=10,接触时间120 min时,ZnO NPs (80 mg)对10 mg/L MB染料的光催化降解效率为92.2%。因此,用竹枝草合成的ZnO NPs是降解废水中MB至少三个循环的潜在光催化剂。
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引用次数: 0
Carbonization of Selected Biological Materials, Trends, and Perspectives 选定生物材料的碳化,趋势和前景
Pub Date : 2022-04-18 DOI: 10.33263/lianbs123.068
The exploration of new materials as well as methods and sources of their production is a constantly growing trend in both scientific and industrial directions. One such method is carbonization, which has attracted a lot of attention over the past decades. Carbonization is the process of preparation of 3D carbonaceous materials with unique properties by thermal treatments with the exclusion of oxygen. A higher specific surface area characterizes the obtained nanoporous carbon materials compared to their precursors, and, consequently, they can be used in such fields as biotechnology, electrochemistry, or electronic industry. Special attention has been directed to the carbonization of nanoorganized biological materials due to their extensive composition and unique hierarchical structure. This review aims to provide insight into the examples of carbonization of selected biomaterials such as polysaccharides (cellulose, chitin) and proteins (keratin, spongin, silk) evidenced by excellent and successful examples from the recent literature. In addition, this work highlights the most significant aspects of diverse experiments, allowing getting inspiration for fields such as materials science and well extreme biomimetics.
探索新材料及其生产方法和来源是科学和工业方向上不断发展的趋势。其中一种方法是碳化,在过去的几十年里引起了很多关注。碳化是在不含氧的条件下通过热处理制备具有独特性能的三维碳质材料的过程。与它们的前体相比,获得的纳米多孔碳材料具有更高的比表面积,因此,它们可以用于诸如生物技术,电化学或电子工业等领域。纳米组织生物材料由于其广泛的组成和独特的层次结构而被特别关注。这篇综述的目的是提供一些生物材料如多糖(纤维素,几丁质)和蛋白质(角蛋白,海绵蛋白,丝)的碳化的例子,从最近的文献中证明了优秀的和成功的例子。此外,这项工作突出了各种实验的最重要方面,为材料科学和极端仿生学等领域提供了灵感。
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引用次数: 2
A DFT Study of Structure, Electronic and Optical Properties of Se-Doped Kesterite Cu2ZnSnS4 (CZTSSe) 掺硒Kesterite Cu2ZnSnS4 (CZTSSe)结构、电子和光学性质的DFT研究
Pub Date : 2022-04-18 DOI: 10.33263/lianbs123.067
In this work, we have studied the geometric structure and electronic and optical properties of Cu2ZnSn(S1-xSex)4 nanocrystals where x = 0, 0.25, 0.50, 0.75, 1.00 by the quantum-chemical calculations within the framework of DFT. For the electronic and optical properties calculations, the effective XC functional and the TB-mBJ potential were used. The calculated structural characteristics show that the volume of these systems increases with increasing the Se concentration. The electronic properties of the Se-doped kesterite Cu2ZnSnS4 show that the bandgap tends to decrease. It was found that the Se-doped material has noticeably increased its absorption capacity. Hence, the efficiency of the Cu2ZnSnS4 in the IR region of radiation improves. The effective reduction bandgap from 1.455 eV to 0.94 eV is observed, which is in gоod agreement with known experimental data for the pure and undoped systems Cu2ZnSnS4 and Cu2ZnSnSе4. The calculated band gap is 1.346 eV for the Cu2ZnSnS3Se system, which is comparable with the optimal bandgap of semiconductors used in photovoltaic applications. It was found that with the increase of the Se concentration, the absorption coefficient increases, thereby resulting in the materials' reflectivity decrease. The calculated optoelectronic parameters and the density of electronic states indicate that the Cu2ZnSnS4:Se system possesses a favorable property, suitable for applications in solar cells technology.
本文在DFT的框架下,通过量子化学计算研究了x = 0,0.25, 0.50, 0.75, 1.00的Cu2ZnSn(S1-xSex)4纳米晶体的几何结构和电子光学性质。电子和光学性质计算采用有效XC泛函和TB-mBJ势。计算的结构特征表明,随着硒浓度的增加,这些体系的体积增大。结果表明,掺硒kesterite Cu2ZnSnS4的带隙减小。结果表明,掺硒材料的吸收能力明显提高。从而提高了Cu2ZnSnS4在辐射红外区的效率。结果表明,纯Cu2ZnSnS4和未掺杂cu2znsnsns4体系的有效带隙从1.455 eV降至0.94 eV,与已知的实验数据基本一致。计算出Cu2ZnSnS3Se系统的带隙为1.346 eV,与光伏应用中半导体的最佳带隙相当。结果表明,随着Se浓度的增加,材料的吸收系数增大,导致材料的反射率降低。计算的光电子参数和电子态密度表明Cu2ZnSnS4:Se体系具有良好的性能,适合应用于太阳能电池技术。
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引用次数: 5
Novel Antibacterial Wound Healing Hydrogels Based On HEC/SA/HA Using Green Chemistry Approach 基于绿色化学方法的HEC/SA/HA新型抗菌伤口愈合水凝胶
Pub Date : 2022-04-18 DOI: 10.33263/lianbs123.069
(HEC/SA/HA/AgNP hydrogels) were successfully prepared using Hyaluronic acid (HA), Sodium alginate (SA), Hydroxyethylcellulose (HEC, and Silver nanoparticles (AgNPs). HEC/SA/HA/AgNP hydrogels were cross-linked via Ca2+ ions. The structural, chemical and physical properties of the hydrogel have been studied, which include: swelling ratio, antibacterial and antifungal activity, and also UV-Vis, FTIR, SEM, EDX after making sponges via the freeze-drying technique. The characteristic peak of UV-Vis spectra revealed the formation of AgNPs in the compound at 411 nm. The FTIR curves showed new peaks that confirmed the oxidation of HEC, and showed the chemical interaction of the three polymers with AgNPs and Ca2+. The SEM images showed monodispersed AgNPs with a size ranging (from 8.2 to 32 nm ). The results from these studies showed that the hydrogel has an excellent performance in swelling ratio. Furthermore, the hydrogel activity against bacteria and fungi was also measured for 72 h, and the results showed that these hydrogels were more effective against the microbes. These results suggested that the crosslinked hydrogel (HEC/HA/SA) with AgNPs might be an excellent dressing for wounds.
采用透明质酸(HA)、海藻酸钠(SA)、羟乙基纤维素(HEC)和纳米银(AgNPs)制备了HEC/SA/HA/AgNP水凝胶。HEC/SA/HA/AgNP水凝胶通过Ca2+离子交联。研究了经冷冻干燥技术制成海绵后的水凝胶的结构、化学和物理性能,包括:膨胀比、抗菌和抗真菌活性,以及紫外可见光谱、红外光谱、扫描电镜、电子能谱等。紫外可见光谱特征峰显示化合物在411 nm处形成AgNPs。FTIR曲线显示出新的峰,证实了HEC的氧化作用,并显示了三种聚合物与AgNPs和Ca2+的化学相互作用。SEM图像显示单分散的AgNPs,尺寸范围为8.2 ~ 32 nm。研究结果表明,该水凝胶具有良好的溶胀比性能。同时,测定了水凝胶对细菌和真菌的抑菌活性,结果表明,水凝胶对微生物的抑菌效果更好。这些结果表明,具有AgNPs的交联水凝胶(HEC/HA/SA)可能是一种良好的伤口敷料。
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引用次数: 0
Structural, Thermal, Optical, Mechanical, and Antibacterial Properties of PLA/Nanoclay/TiO2 Nanocomposite Films PLA/纳米粘土/TiO2纳米复合膜的结构、热、光学、机械和抗菌性能
Pub Date : 2022-04-18 DOI: 10.33263/lianbs123.070
In this report, Polylactide/Nanoclay/TiO2 nanocomposite films with two different weight percentages (2wt% and 5wt %) of clay and TiO2 nanoparticles were prepared by a cost-effective approach. A solvent casting process with the help of a cost-effective film applicator was used to prepare nanocomposite films. The surface morphology investigations revealed the agglomeration of fillers at higher weight percentages and uniform mixing of fillers at lower weight percentages. The crystallinity of the prepared films did not alter much with the nanofiller addition. Nanofillers with a 2wt% concentration in the PLA matrix enhanced thermal and mechanical properties significantly. The PLA nanocomposite films have exhibited an intense broad emission band in violet color with a wavelength of ≈420 nm. In addition, the antibacterial activity of polylactic acid nanocomposite films was investigated against Gram-positive S. aureus and Gram-negative E. coli bacteria. The enhanced antibacterial activity is observed for a 5wt% concentration of nanofillers. The results showed that the antibacterial activity increases with nanofiller concentration. This study presents a simple and cost-effective approach to preparing nanocomposite films with tuneable properties of mechanical, thermal, and antibacterial activity.
本文采用高性价比的方法,制备了黏土和TiO2的重量百分比分别为2wt%和5wt %的聚丙交酯/纳米粘土/TiO2纳米复合薄膜。采用溶剂浇铸工艺,在低成本的涂膜器的帮助下制备了纳米复合薄膜。表面形貌的研究表明,填料在较高的重量百分比的团聚和均匀混合的填料在较低的重量百分比。纳米填料的加入对制备膜的结晶度影响不大。在PLA基体中加入2wt%浓度的纳米填料,可以显著提高材料的热性能和力学性能。制备的聚乳酸纳米复合薄膜在波长约420 nm的紫外光下具有较强的宽发射带。此外,还研究了聚乳酸纳米复合膜对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌的抑菌活性。纳米填料浓度为5wt%时,抗菌活性增强。结果表明,纳米填料的浓度越大,抗菌活性越强。本研究提出了一种简单而经济的方法来制备具有可调机械、热学和抗菌活性的纳米复合薄膜。
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引用次数: 0
Microwave-Assisted One-Pot Synthesis of Aminopyrimidine Scaffolds and their Biological Evaluation 微波辅助一锅法合成氨基嘧啶支架及其生物学评价
Pub Date : 2022-04-15 DOI: 10.33263/lianbs123.063
Synthesis of aminopyrimidine derivatives was carried out by microwave synthesis. This microwave-assisted heating is an eco-friendly method. Aminopyrimidines were modified by using substituted benzaldehydes, acetophenones, and uracil during synthesis. Compounds were screened pharmacologically against the cancer cell lines. To synthesize the uracil substituted amino pyrimidines involving aldol condensation. The Invitro cytotoxicity studies against the cancer cell lines using MTT assay and the antimicrobial resistance using the bacterial and fungal strains. Aminopyrimidines were synthesized by condensation of chalcones and guanidine and further substituted with uracil. These aminopyrimidine derivatives were analyzed by FT-IR, 1H NMR, and MASS spectra. Compounds were evaluated for cytotoxicity studies against the HeLa and Vero cancer cell lines using an MTT assay. Antibacterial and antifungal activity by cup plate and two-fold serial dilution method was done. Substituted amino pyrimidines were synthesized by microwave-assisted heating and yielded in the range of 33-56%. Melting point, solubility, and spectral analysis were carried out. All the compounds exhibited no cytotoxicity. The compounds C7, C9, and C12 were viable the most at the concentration of 625µg/ml against HeLa and Vero cell lines. The compound C10 showed the highest zone of inhibition against the bacteria Mycobacterium phlei, Bacillus cereus, and Escherichia coli by both cup plate and serial dilution methods. It exhibited more inhibition against the fungi Aspergillus niger than the bacteria. The compounds with nitro substituted were found to be more effective than any other substitution. The aminopyrimidine derivatives synthesized by microwave procedure were evaluated for antimicrobial screening. It resulted in similar inhibition as ciprofloxacin. This work would serve the researchers for the eco-friendly method of synthesis and screening drugs for antimicrobial activity.
采用微波合成法合成了氨基嘧啶衍生物。这种微波辅助加热是一种环保的方法。在合成过程中,氨基嘧啶被取代苯甲醛、苯乙酮和尿嘧啶修饰。化合物对肿瘤细胞系进行了药理学筛选。通过缩醛反应合成尿嘧啶取代的氨基嘧啶。用MTT法对肿瘤细胞株进行体外细胞毒性研究,并用细菌和真菌菌株对肿瘤细胞株进行耐药性研究。以查尔酮和胍为原料缩合合成氨基嘧啶,再用尿嘧啶取代。用FT-IR、1H NMR和质谱对这些氨基嘧啶衍生物进行了分析。使用MTT法评估化合物对HeLa和Vero癌细胞系的细胞毒性研究。用杯板法和两次连续稀释法测定了其抑菌和抗真菌活性。采用微波辅助加热法合成取代氨基嘧啶,收率在33-56%之间。进行了熔点、溶解度和光谱分析。所有化合物均无细胞毒性。化合物C7、C9和C12在浓度为625µg/ml时对HeLa和Vero细胞株的活性最强。在杯板法和连续稀释法中,化合物C10对真菌分枝杆菌、蜡样芽孢杆菌和大肠杆菌的抑制作用均达到最高。对真菌黑曲霉的抑制作用强于对细菌的抑制作用。发现硝基取代的化合物比任何其他取代都更有效。对微波合成的氨基嘧啶衍生物进行抗菌筛选。其抑制作用与环丙沙星相似。本研究为抗菌药物的生态友好型合成和筛选提供了理论依据。
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引用次数: 0
Antipyretic Activity of Medicinal Plants from the Thal Desert 塔尔沙漠药用植物的解热作用
Pub Date : 2022-04-15 DOI: 10.33263/lianbs123.062
The Thal Desert in Punjab, Pakistan, is known for being home to a number of plants, many of which are utilized by the local natural healers to treat various inflammatory and non-inflammatory conditions. However, no scientific studies to date have evaluated these plant-based therapeutics. Here we report on the results of an antipyretic study of two plants from the Thal Desert, namely Fagonia bruguieri and Tamarix dioica, in an animal model. Hydro-alcoholic extracts of the two plants were tested for their ability to reduce pyrexia induced by Escherichia coli in rabbits. Rabbits were divided into five separate groups for each plant extract tested, numbering five animals each. They included a negative control group where animals were subjected to no treatment and a positive control group subjected to the conventional treatment with 150 mg/kg paracetamol. Animals comprising the additional three sample groups were treated with 100, 250, and 500 mg/kg of the experimental medicines in the form of hydro-ethanol concentrates of Fagonia bruguieri and Tamarix dioica. The treatment with the plant concentrates showed a highly positive antipyretic effect relative to both controls in these animal trials. The average body temperatures of the animals 5 h after the treatment with either Tamarix dioica or Fagonia bruguieri were significantly (p < 0.05) lower than those in both control groups. The differences were not as significant at lower time points, suggesting that the plant extracts exhibit slower pharmacokinetics and have a stronger and longer-lasting effect than the conventional treatment. Another insight emerging from this study is that the hydro-ethanol concentrates of the plants assessed in this examination exhibit a dose-dependent antipyretic effect. The antipyretic activity of Fagonia bruguieri and Tamarix dioica is pronounced in an animal model. Further investigations of these plant species emerge as imperative from this study.
巴基斯坦旁遮普的塔尔沙漠以多种植物的家园而闻名,其中许多植物被当地的自然治疗师用来治疗各种炎症和非炎症性疾病。然而,迄今为止还没有科学研究评估过这些基于植物的治疗方法。在这里,我们报告了两种来自塔尔沙漠的植物的解热研究结果,即Fagonia bruguieri和柽柳,在动物模型中。对两种植物的水酒精提取物进行了降低家兔大肠杆菌所致发热的实验。每种植物提取物将家兔分成5组,每组5只。他们包括一个阴性对照组,动物不进行任何治疗,阳性对照组接受150mg /kg扑热息痛的常规治疗。另外三个样品组分别给予100、250和500 mg/kg的实验药物,其形式为布鲁吉火柴和柽柳的氢乙醇浓缩物。在这些动物试验中,与两种对照相比,植物浓缩液治疗显示出高度积极的解热作用。柽柳和布氏柴处理后5 h动物平均体温均显著低于对照组(p < 0.05)。在较低的时间点上,差异不那么显著,这表明植物提取物表现出较慢的药代动力学,比传统治疗具有更强、更持久的效果。从这项研究中得出的另一个见解是,本研究中评估的植物的氢乙醇浓缩物表现出剂量依赖性的解热作用。在动物模型中,布鲁吉尼亚和柽柳具有明显的解热活性。进一步研究这些植物物种势在必行。
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引用次数: 0
Evaluation of Phytocompounds of Vitis vinifera, Tabernaemontana corymbosa and Aloe vera against JAB1: A Strategy to Treat Cervical Cancer 葡萄、大蒙塔纳和芦荟抗JAB1的药效评价:宫颈癌的治疗策略
Pub Date : 2022-04-15 DOI: 10.33263/lianbs123.066
JAB1 or C-Jun activation domain-binding protein-1 plays a role in controlling cellular proliferation, cell apoptosis, cell cycle, and regulating genomic instability as well as DNA damage response. JAB1 dysregulation contributes to oncogenesis via deactivating tumor suppressor genes. Vitis vinifera, Tabernaemontana corymbosa, and Aloe vera have been known for their antitumor functions. However, the inhibitory role of phytocompounds derived from Vitis vinifera, Tabernaemontana corymbosa, and Aloe barbadensis miller (Aloe vera) against JAB1 has not yet been elucidated. Therefore, we studied the naturally derived compounds from Vitis vinifera, Tabernaemontana corymbosa, and Aloe vera, which can interact and decrease the activities of JAB1 using in-silico analysis. Eighty-one compounds were screened using PyRx and further analyzed via Lipinski's rule. Further, on executing molecular docking studies on the sixty selected compounds, Iboluteine was found to be a potent inhibitor of JAB1 and should further be explored in in-vitro studies to substantiate these assertions. Phytocompounds are a reservoir of bioactive molecules that can be particularly useful in treating cervical cancer due to their limited toxicity and amenability from the development of drug resistance. Thus, this study aims to identify possible naturally derived compounds from Vitis vinifera, Tabernaemontana corymbosa, and Aloe vera, which can selectively decrease the activities of JAB1 that has the potential to be a crucial anti-cancer therapeutic molecule against cervical cancer.
JAB1或C-Jun活化结构域结合蛋白-1在控制细胞增殖、细胞凋亡、细胞周期、调节基因组不稳定性和DNA损伤应答等方面发挥作用。JAB1的失调通过使肿瘤抑制基因失活来促进肿瘤的发生。葡萄、山楂和芦荟因其抗肿瘤功能而闻名。然而,从葡萄树(Vitis vinifera)、塔伯纳蒙塔纳(tabernamontana corymbosa)和芦荟(Aloe barbadensis miller)中提取的植物化合物对JAB1的抑制作用尚未阐明。因此,我们采用芯片分析的方法研究了葡萄(Vitis vinifera)、塔伯纳蒙塔纳(tabernamontana corymbosa)和芦荟(Aloe vera)中能够相互作用并降低JAB1活性的天然化合物。使用PyRx筛选了81个化合物,并通过Lipinski规则进一步分析。此外,在对60种选定的化合物进行分子对接研究时,发现Iboluteine是一种有效的JAB1抑制剂,应该在体外研究中进一步探索以证实这些断言。植物化合物是生物活性分子的储存库,由于其有限的毒性和易受耐药性发展的影响,在治疗宫颈癌方面特别有用。因此,本研究旨在从葡萄(Vitis vinifera)、tabernamontana corymbosa和芦荟中鉴定可能的天然衍生化合物,这些化合物可以选择性地降低JAB1的活性,而JAB1有可能成为宫颈癌的重要抗癌治疗分子。
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引用次数: 2
Selection of Carrier Materials to Formulate Bioinoculant Package for Promoting Seed Germination 促进种子萌发的生物接种剂包装载体材料的选择
Pub Date : 2022-04-15 DOI: 10.33263/lianbs123.065
Biofertilizers are a novel technique for Indian agriculture that has the potential to address many of the shortcomings of chemical-based technology. Plant growth-promoting (PGP) traits such as IAA, P-solubilization, ACC deaminase, NH3, HCN, EPS, siderophore synthesis, and biofilm formation have been demonstrated in two salt-tolerant PGPR, BST YS1 42 (Bacillus cereus) and CHR JH203 (Bacillus marisflavi). They are most commonly utilized to make carrier-based compositions. This study aimed to evaluate how different carrier-based formulations of salt-tolerant PGPR performed in seedlings of pea and maize plants. The chosen PGPR was mass replicated in the lab and put into seedlings via a variety of carriers, including charcoal powder, dry pea peel powder, tea leaf powder, hay+2%peptone, and cowdung powder. The influence of bio inoculants on seedling growth of Pisum sativum and Zea mays seedlings was investigated. There was a substantial variation in seedling germination in both pea and maize. The result was different depending on the type of carrier materials utilized in the bioformulation process. The results showed that seedling germination was better with the bioformulation made with charcoal and tea leaf powder. As a result, we believe it might be used to alleviate abiotic stresses in a cost-effective and environmentally friendly manner.
生物肥料是印度农业的一种新技术,它有可能解决化学技术的许多缺点。在两种耐盐PGPR BST ys142(蜡样芽孢杆菌)和CHR JH203 (marisflavi芽孢杆菌)中发现了IAA、p溶解、ACC脱氨酶、NH3、HCN、EPS、铁载体合成和生物膜形成等植物生长促进(PGP)性状。它们最常用于制造基于载体的组合物。本研究旨在评估不同的耐盐PGPR载体配方在豌豆和玉米幼苗中的表现。选择的PGPR在实验室大量复制,并通过木炭粉、干豌豆皮粉、茶叶粉、干草+2%蛋白胨和牛粪粉等多种载体植入幼苗。研究了生物接种剂对油菜和玉米幼苗生长的影响。豌豆和玉米的幼苗发芽率有很大差异。根据在生物制剂过程中使用的载体材料的类型,结果是不同的。结果表明,以木炭和茶叶粉配制的生物制剂能较好地促进幼苗萌发。因此,我们相信它可以以一种成本效益和环境友好的方式来缓解非生物压力。
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引用次数: 2
Green Synthesis of Tecoma stans Flower and Leaf Extracts: Characterization and Anti-Proliferative Activity in Colorectal Cancer Cell Lines 藤花和叶提取物的绿色合成:表征及其对结直肠癌细胞系的抗增殖活性
Pub Date : 2022-04-15 DOI: 10.33263/lianbs123.061
Since times immemorial, many plant species have been utilized to cure severe diseases. A wide range of diversification has been observed in various medicinal plants, which are indeed able to cure several deadly diseases. The presence of secondary metabolites is a high priority for their medicinal characteristics. This study focused on T. stans (Yellow bells), a shrub that grows profoundly in tropical and sub-tropical regions. Although many studies have been done on the medicinal value of this plant, not much has been done on cancer treatment and nanomedicine. Green synthesized silver nanoparticles are an eco-friendly approach to delivering the drug to the target size. Nano appearance is an add-on advantage of these compounds. Hence, it is emerging in medicine. Colorectal cancer is the fourth deadliest one globally. Hence the synthesized silver nanoparticles of T. stans flower and leaf extracts showed cytotoxically and wound healing properties on colorectal cancer cell lines (HCT 116 and SW 480). Synthesis of silver nanoparticles confirmation is done by Ultra Violet Visible spectrophotometry and Particle size analyzer. All the results showcase the beneficial effects of silver nanoparticles synthesized plant extracts and may be used as a novel medicine in the field of chemotherapy.
自古以来,许多植物物种就被用来治疗严重的疾病。在各种药用植物中已经观察到广泛的多样化,这些植物确实能够治疗几种致命的疾病。次级代谢物的存在是其药用特性的高度优先考虑。本研究以黄钟属灌木(T. stans)为研究对象,黄钟属灌木广泛生长在热带和亚热带地区。虽然对这种植物的药用价值进行了许多研究,但对癌症治疗和纳米医学的研究却不多。绿色合成银纳米颗粒是一种环保的方法,可以将药物输送到目标尺寸。纳米外观是这些化合物的附加优势。因此,它正在医学中出现。结直肠癌是全球第四大致命疾病。因此,紫花苜蓿花和叶提取物合成的银纳米颗粒对结直肠癌细胞系(HCT 116和SW 480)具有细胞毒性和伤口愈合特性。采用紫外可见分光光度法和粒度分析仪对银纳米粒子的合成进行了验证。这些结果表明,银纳米颗粒合成的植物提取物具有良好的药理作用,有望作为一种新型药物应用于化疗领域。
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引用次数: 0
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Letters in Applied NanoBioScience
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