The study concentrated on the prospects of multifunctional core-shell that can incorporate multiple functions simultaneously. For the sharp and precise assembling of core-shell nanostructures (CS-Ns) combining ferromagnetic-core and semiconducting-shell into a single material with mouldable fluorescence and magnetic features, the seed-mediated aqueous growth technique was flourished. SrFe12O19/CdS CS-Ns were designed to gratify the requirement of magneto-fluorescent features in a solo unit. Characterization techniques such as XRD, VSM and photoluminescence spectroscopy (PL) was used to analyze the as-synthesized CS-Ns. XRD spectra confirm the CS-Ns formation with the pure phase. PL results show that the CS-Ns follow the emission profile of the CdS shell. CS-Ns formation leads to a much better particle size distribution. In VSM analysis, it was observed that the saturation of the hysteresis loop is decayed many times as that of the bare core because of the semiconducting shell covering over the core. Altogether the results were in good agreement with one another. Because of the permanent magnetic nature of SrFe12O19 (1000°C), these CS-Ns are used in the magnetic separation process, where the ferromagnetic core aids in magnetic manipulation, and the fluorescent shell aids in detecting the path of the separated entity.
{"title":"Development of High Coercivity/High Fluorescence Hybrid nanostructures","authors":"D. Rawat, R. Singh","doi":"10.33263/lianbs122.048","DOIUrl":"https://doi.org/10.33263/lianbs122.048","url":null,"abstract":"The study concentrated on the prospects of multifunctional core-shell that can incorporate multiple functions simultaneously. For the sharp and precise assembling of core-shell nanostructures (CS-Ns) combining ferromagnetic-core and semiconducting-shell into a single material with mouldable fluorescence and magnetic features, the seed-mediated aqueous growth technique was flourished. SrFe12O19/CdS CS-Ns were designed to gratify the requirement of magneto-fluorescent features in a solo unit. Characterization techniques such as XRD, VSM and photoluminescence spectroscopy (PL) was used to analyze the as-synthesized CS-Ns. XRD spectra confirm the CS-Ns formation with the pure phase. PL results show that the CS-Ns follow the emission profile of the CdS shell. CS-Ns formation leads to a much better particle size distribution. In VSM analysis, it was observed that the saturation of the hysteresis loop is decayed many times as that of the bare core because of the semiconducting shell covering over the core. Altogether the results were in good agreement with one another. Because of the permanent magnetic nature of SrFe12O19 (1000°C), these CS-Ns are used in the magnetic separation process, where the ferromagnetic core aids in magnetic manipulation, and the fluorescent shell aids in detecting the path of the separated entity.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83037543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vismitha S. Patil, B. Saraswathi, R. M. Hodlur, J. AmithYadavH., S. V. Halse, Muttanagoud N. Kalasad
Nontoxic and biocompatible silver-chitosan colloids were prepared by direct chemical reduction. The Ag-chitosan colloids are drop cast on a glass slide and left to dry to obtain uniform, homogeneous films. The presence of chitosan prevented the growth of silver nanoparticles from agglomeration. The occurrence of localized surface plasmon resonance (LSPR) at ~ 400 nm in the optical absorption spectra indicated the formation of Ag nanoparticles which is the characteristic property of metal nanoparticles. The -prepared colloidal Ag nanoparticles are chemically stable and remain colloidal even after aging. The estimated average particle size is about 14nm and the face-centered cubic phase was observed in the XRD pattern. SEM images clearly showed the homogeneous distribution of silver nanoparticles.
{"title":"Optical and Structural Study of Biocompatible Silver-Chitosan Colloids","authors":"Vismitha S. Patil, B. Saraswathi, R. M. Hodlur, J. AmithYadavH., S. V. Halse, Muttanagoud N. Kalasad","doi":"10.33263/lianbs122.049","DOIUrl":"https://doi.org/10.33263/lianbs122.049","url":null,"abstract":"Nontoxic and biocompatible silver-chitosan colloids were prepared by direct chemical reduction. The Ag-chitosan colloids are drop cast on a glass slide and left to dry to obtain uniform, homogeneous films. The presence of chitosan prevented the growth of silver nanoparticles from agglomeration. The occurrence of localized surface plasmon resonance (LSPR) at ~ 400 nm in the optical absorption spectra indicated the formation of Ag nanoparticles which is the characteristic property of metal nanoparticles. The -prepared colloidal Ag nanoparticles are chemically stable and remain colloidal even after aging. The estimated average particle size is about 14nm and the face-centered cubic phase was observed in the XRD pattern. SEM images clearly showed the homogeneous distribution of silver nanoparticles.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75316355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The compound 4-nitrophenylisocyanate is known for its various biological properties and class of compounds in medicinal chemistry. In this paper, we are reporting the DFT studies of 4-nitrophenylisocyanate (NPIC). To better understand molecular properties, the computational study, optimized molecular geometry, and reactive parameters were investigated and calculated by employing the method of DFT and B3LYP/6-311++G(d, p) basis set. The DFT calculations were performed to analyze the frontier molecular orbitals (HOMO-LUMO). The energy difference between HOMO - LUMO is 4.516 eV, and the MEP was traced to find the reactive sites of the compound. In addition, theoretical UV-visible spectrum and vibrational spectra (FT-IR) were obtained in the gas phase using the TD-DFT method. By using pkCSM toxicity of the compound was also predicted. The Quantum Theory of Atoms in Molecules (QTAIM) framework is used to calculate topological parameters. Different intermolecular interactions are described using terms like Reduced Density Gradient (RDG), Non-Covalent Interactions (NCI), electron density, and electron localization function and electron cloud present in the NPIC molecule.
{"title":"Investigation on Quantum Computational Analysis and Toxicity Prediction of 4-Nitrophenylisocyanate","authors":"","doi":"10.33263/lianbs122.045","DOIUrl":"https://doi.org/10.33263/lianbs122.045","url":null,"abstract":"The compound 4-nitrophenylisocyanate is known for its various biological properties and class of compounds in medicinal chemistry. In this paper, we are reporting the DFT studies of 4-nitrophenylisocyanate (NPIC). To better understand molecular properties, the computational study, optimized molecular geometry, and reactive parameters were investigated and calculated by employing the method of DFT and B3LYP/6-311++G(d, p) basis set. The DFT calculations were performed to analyze the frontier molecular orbitals (HOMO-LUMO). The energy difference between HOMO - LUMO is 4.516 eV, and the MEP was traced to find the reactive sites of the compound. In addition, theoretical UV-visible spectrum and vibrational spectra (FT-IR) were obtained in the gas phase using the TD-DFT method. By using pkCSM toxicity of the compound was also predicted. The Quantum Theory of Atoms in Molecules (QTAIM) framework is used to calculate topological parameters. Different intermolecular interactions are described using terms like Reduced Density Gradient (RDG), Non-Covalent Interactions (NCI), electron density, and electron localization function and electron cloud present in the NPIC molecule.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85360923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transition metal dichalcogenides (TMDCs) have found diverse applications for intrinsic semiconducting and tunable electronic properties mediated via the van der Waals interaction between the adjacent chalcogen planes. Therefore, the large-scale production of TMDCs without compromising the material properties is the major challenge at the present moment. We follow a simple, cost-effective, and environmentally friendly hydrothermal technique for synthesizing tin disulfide (SnS2). The optical properties are investigated using UV-visible, photoluminescence (PL), Raman, and FTIR spectroscopy. The UV-visible absorption spectra of pure SnS2 show a broad absorption peak located at 340 nm, and the corresponding optical band gap energies are estimated to be 2.14 and 4.02 eV, respectively. The PL spectra display a sharp emission peak at 561 nm due to the radiative recombination of bound excitons for the excitation wavelength of 340 nm. FTIR is used to observe the existence of functional groups in the material. The absorption peak observes at 625 cm-1 corresponds to the vibration of the Sn-S bond. From Raman spectra, a sharp peak appears at 314 cm-1, corresponding to the A1g mode of pure SnS2, which occurs due to the out-of-plane stretching vibration of sulfur atoms in the SnS2 material. The XRD is used to identify structural phases. The sharp diffraction peaks at 2Ɵ = 15.17ᴼ and 28.55ᴼ corresponds to (001) and (100) planes, respectively, that suggest the hexagonal phase of pure SnS2. Interplanar spacing is estimated using Bragg’s law, and the value is found to be 5.83 Å. The average crystallite size is estimated to be 28 nm from the Williamson-Hall plot, which is comparable with the crystallite size calculated from Scherrer’s formula.
{"title":"Optical and Structural Studies of Tin Disulfide (SnS2) Synthesized by Facile Hydrothermal Method","authors":"","doi":"10.33263/lianbs122.047","DOIUrl":"https://doi.org/10.33263/lianbs122.047","url":null,"abstract":"Transition metal dichalcogenides (TMDCs) have found diverse applications for intrinsic semiconducting and tunable electronic properties mediated via the van der Waals interaction between the adjacent chalcogen planes. Therefore, the large-scale production of TMDCs without compromising the material properties is the major challenge at the present moment. We follow a simple, cost-effective, and environmentally friendly hydrothermal technique for synthesizing tin disulfide (SnS2). The optical properties are investigated using UV-visible, photoluminescence (PL), Raman, and FTIR spectroscopy. The UV-visible absorption spectra of pure SnS2 show a broad absorption peak located at 340 nm, and the corresponding optical band gap energies are estimated to be 2.14 and 4.02 eV, respectively. The PL spectra display a sharp emission peak at 561 nm due to the radiative recombination of bound excitons for the excitation wavelength of 340 nm. FTIR is used to observe the existence of functional groups in the material. The absorption peak observes at 625 cm-1 corresponds to the vibration of the Sn-S bond. From Raman spectra, a sharp peak appears at 314 cm-1, corresponding to the A1g mode of pure SnS2, which occurs due to the out-of-plane stretching vibration of sulfur atoms in the SnS2 material. The XRD is used to identify structural phases. The sharp diffraction peaks at 2Ɵ = 15.17ᴼ and 28.55ᴼ corresponds to (001) and (100) planes, respectively, that suggest the hexagonal phase of pure SnS2. Interplanar spacing is estimated using Bragg’s law, and the value is found to be 5.83 Å. The average crystallite size is estimated to be 28 nm from the Williamson-Hall plot, which is comparable with the crystallite size calculated from Scherrer’s formula.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91207682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This research aimed to find a suitable vehicle (media) for dispersing titanium dioxide nanoparticles (TiO2 NPs) to investigate their toxicity in laboratory rodents.The TiO2 NPs were suspended in different vehicles viz., distilled water, Tween 80 (0.1% v/v), normal saline, normal saline + Tween 80 (0.1% v/v) and carboxymethylcellulose (CMC; 0.1%, 0.2%, 0.3% or 0.4% w/v). The hydrodynamic diameters, zeta potential, and polydispersity index were measured by the dynamic light scattering (DLS) technique by employing a zeta sizer. The TiO2 NPs in Tween 80 (0.1% v/v) and CMC (0.2% w/v) showed lesser hydrodynamic diameter compared to other vehicles. Further, TiO2 NPs dispersed in CMC (0.1%, 0.2%, or 0.3% w/v) showed relatively better zeta potential in terms of better stability than other media examined. The polydispersity index of nanoparticles was relatively less for CMC: 0.1% w/v followed by CMC: 0.2% w/v. Thus, it is concluded that CMC (0.2% w/v) can be used as an ideal vehicle among the various media examined for delivery of TiO2 NPs for toxicity testing in laboratory rodents.
{"title":"Comparative Studies on Dispersion Characters of Titanium Dioxide (TiO2) Nanoparticles for Rodent Toxicology Studies","authors":"","doi":"10.33263/lianbs122.051","DOIUrl":"https://doi.org/10.33263/lianbs122.051","url":null,"abstract":"This research aimed to find a suitable vehicle (media) for dispersing titanium dioxide nanoparticles (TiO2 NPs) to investigate their toxicity in laboratory rodents.The TiO2 NPs were suspended in different vehicles viz., distilled water, Tween 80 (0.1% v/v), normal saline, normal saline + Tween 80 (0.1% v/v) and carboxymethylcellulose (CMC; 0.1%, 0.2%, 0.3% or 0.4% w/v). The hydrodynamic diameters, zeta potential, and polydispersity index were measured by the dynamic light scattering (DLS) technique by employing a zeta sizer. The TiO2 NPs in Tween 80 (0.1% v/v) and CMC (0.2% w/v) showed lesser hydrodynamic diameter compared to other vehicles. Further, TiO2 NPs dispersed in CMC (0.1%, 0.2%, or 0.3% w/v) showed relatively better zeta potential in terms of better stability than other media examined. The polydispersity index of nanoparticles was relatively less for CMC: 0.1% w/v followed by CMC: 0.2% w/v. Thus, it is concluded that CMC (0.2% w/v) can be used as an ideal vehicle among the various media examined for delivery of TiO2 NPs for toxicity testing in laboratory rodents.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91257553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
López-Ramos Maria, Figueroa‐Valverde Lauro, D. Francisco, Rosas-Nexticapa, Marcela, Cervantes-Ortega Catalina, Alvarez-Ramirez Magdalena, Mateu-Armad Maria, Virgínia, Lopez-Gutierrez Tomas
There are some reports which show that omega-3 fatty acids extracted from either animals or plants can be used to reduce glucose levels in diabetic patients; however, the results are very confusing; perhaps this phenomenon is due to the different protocols used. Analyzing these data, this study aimed to evaluate the biological activity of the oil extracted from Crocodylus moreletii at a dose of 100, 200, and 300 µl/kg using metformin glibenclamide and sodium oleate as controls in a diabetic rat model. The results showed that oil Crocodylus moreletii lowered glucose levels in a dose-dependent manner than untreated diabetic rats. Furthermore, the effects produced by Crocodylus moreletii oil and sodium oleate on glucose concentration were very similar. However, the biological activity exerted by glibenclamide and metformin on glucose levels was different from to effect induced by Crocodylus moreletii oil and sodium oleate. In conclusion, the biological activity of Crocodylus moreletii oil is interesting and could be considered a therapeutic alternative for the treatment of diabetes.
{"title":"Evaluation of Biological Activity of Oil Crocodylus moreletii on Glucose levels Using a Diabetic Model","authors":"López-Ramos Maria, Figueroa‐Valverde Lauro, D. Francisco, Rosas-Nexticapa, Marcela, Cervantes-Ortega Catalina, Alvarez-Ramirez Magdalena, Mateu-Armad Maria, Virgínia, Lopez-Gutierrez Tomas","doi":"10.33263/lianbs122.046","DOIUrl":"https://doi.org/10.33263/lianbs122.046","url":null,"abstract":"There are some reports which show that omega-3 fatty acids extracted from either animals or plants can be used to reduce glucose levels in diabetic patients; however, the results are very confusing; perhaps this phenomenon is due to the different protocols used. Analyzing these data, this study aimed to evaluate the biological activity of the oil extracted from Crocodylus moreletii at a dose of 100, 200, and 300 µl/kg using metformin glibenclamide and sodium oleate as controls in a diabetic rat model. The results showed that oil Crocodylus moreletii lowered glucose levels in a dose-dependent manner than untreated diabetic rats. Furthermore, the effects produced by Crocodylus moreletii oil and sodium oleate on glucose concentration were very similar. However, the biological activity exerted by glibenclamide and metformin on glucose levels was different from to effect induced by Crocodylus moreletii oil and sodium oleate. In conclusion, the biological activity of Crocodylus moreletii oil is interesting and could be considered a therapeutic alternative for the treatment of diabetes.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84623437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hesperidin is a plant-derived flavonoid, abundantly present in the different citrus species, including lemon, orange, lime, and grapefruit. It possesses the diverse biological potential of therapeutic significance, including anti-inflammatory, anti-adipogenic, antioxidant, insulin-sensitizing, antimicrobial, neuroprotective, and anti-carcinogenic activities. The objective of the present study was to enhance the dissolution characteristics of the model drug by increasing the solubility and release rate of hesperidin through solid dispersions using natural polymers by the hot-melt extrusion method. The compatibility analysis was carried out through Fourier Transform-Infrared Spectroscopy (FT-IR) and Differential scanning calorimetry (DSC). The kinetic studies for drug release mechanisms were characterized through zero-order, first-order, Higuchi, Korsmeyer-Peppas, and Hixson-Crowell models. The dissolution analysis of solid dispersions showed exhibited more than 99% drug released. The optimized formulation was found to follow the Higuchi model of drug release kinetics with an R2 value of 0.919. Solid dispersions containing natural polymers prepared through the hot-melt extrusion method exhibited significant enhancement in the release profile compared to a pure drug, hesperidin.
{"title":"Formulation and Evaluation of Solid Dispersions of Poorly Water-Soluble Drug- Hesperidin","authors":"","doi":"10.33263/lianbs122.050","DOIUrl":"https://doi.org/10.33263/lianbs122.050","url":null,"abstract":"Hesperidin is a plant-derived flavonoid, abundantly present in the different citrus species, including lemon, orange, lime, and grapefruit. It possesses the diverse biological potential of therapeutic significance, including anti-inflammatory, anti-adipogenic, antioxidant, insulin-sensitizing, antimicrobial, neuroprotective, and anti-carcinogenic activities. The objective of the present study was to enhance the dissolution characteristics of the model drug by increasing the solubility and release rate of hesperidin through solid dispersions using natural polymers by the hot-melt extrusion method. The compatibility analysis was carried out through Fourier Transform-Infrared Spectroscopy (FT-IR) and Differential scanning calorimetry (DSC). The kinetic studies for drug release mechanisms were characterized through zero-order, first-order, Higuchi, Korsmeyer-Peppas, and Hixson-Crowell models. The dissolution analysis of solid dispersions showed exhibited more than 99% drug released. The optimized formulation was found to follow the Higuchi model of drug release kinetics with an R2 value of 0.919. Solid dispersions containing natural polymers prepared through the hot-melt extrusion method exhibited significant enhancement in the release profile compared to a pure drug, hesperidin.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76394773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Figueroa‐Valverde Lauro, D. Francisco, Rosas-Nexticapa Marcela, López-Ramos, Mária, Alvarez-Ramirez Magdalena, M. Virginia, Lopez Gutierrez, Tomáš
There are drugs such as cephalosporin, penicillins, aminoglycosides, quinolones for the treatment of infectious diseases; however, some of these drugs can produce bacterial resistance. This research aimed to synthesize six oxapentacyclo derivatives to evaluate their biological activity against some Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Streptococcus pneumoniae using the minimum inhibitory concentration method. The results showed that the methods used in this study produce a good yield of each product. Furthermore, the chemical structure of compounds 2 to 7 was determined using 1H and 13C NMR spectroscopic techniques. Other data showed that only compounds 3 and 5 decreased the growth bacterial of Garam-negative and Gram-positive bacteria; these data suggest that compounds 3 and 5 could be considered good antibacterial agents against infectious diseases produced by Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Streptococcus pneumoniae.
{"title":"Synthesis and Evaluation Biological Activity of Six Oxapentacyclo Derivatives on Gram Negative and Gram Postive Bacteria","authors":"Figueroa‐Valverde Lauro, D. Francisco, Rosas-Nexticapa Marcela, López-Ramos, Mária, Alvarez-Ramirez Magdalena, M. Virginia, Lopez Gutierrez, Tomáš","doi":"10.33263/lianbs122.043","DOIUrl":"https://doi.org/10.33263/lianbs122.043","url":null,"abstract":"There are drugs such as cephalosporin, penicillins, aminoglycosides, quinolones for the treatment of infectious diseases; however, some of these drugs can produce bacterial resistance. This research aimed to synthesize six oxapentacyclo derivatives to evaluate their biological activity against some Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Streptococcus pneumoniae using the minimum inhibitory concentration method. The results showed that the methods used in this study produce a good yield of each product. Furthermore, the chemical structure of compounds 2 to 7 was determined using 1H and 13C NMR spectroscopic techniques. Other data showed that only compounds 3 and 5 decreased the growth bacterial of Garam-negative and Gram-positive bacteria; these data suggest that compounds 3 and 5 could be considered good antibacterial agents against infectious diseases produced by Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Streptococcus pneumoniae.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85692021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashraf Maher Sulaiman, Ali Saeed Abdulaziz, Amina Mohamed Almutawea, Sarà, A. Alansari, Fatema Mohamed Aldoseri, Salma A. Bekhit, -. SalwaMutlaqAl, Thawadi, S. Alqallaf, A. Bekhit
Warnings by WHO concerning the antibacterial resistance was an encouragement to investigate the antibacterial effects of extracted and purchased Salvia officinalis essential oils against S. aureus, L. monocytogenes, S. pyogenes, E. coli, P. aeruginosa, and K. pneumonia by the agar well diffusion method. Besides, the checkerboard method evaluated the potential synergistic antibacterial activity of volatile sage oil and meropenem against multi-drug resistant E. coli. Results showed that the purchased oil did not have antimicrobial activity against any of the tested pathogens, while the extracted oil of S. officinalis inhibited the growth of all the tested microorganisms except the MDR K. pneumonia. The extracted oil showed the highest activity against the E. coli with an IZ of 18±0.4 mm and MIC of 6.25± 0.2 mg/ml, and the lowest activity was recorded against P. aeruginosa with an IZ of 10±0.2 mm and MIC of 25 mg/ml. In addition, SoEO showed a promising synergistic effect with meropenem against MDR E. coli. Results suggest that the EOs of S. officinalis possess antimicrobial activity, and therefore, they can be used to treat infections caused by some pathogens.
{"title":"Evaluation of the Antibacterial Effect of Salvia Officinalis Essential Oil and its Synergistic Effect with Meropenem","authors":"Ashraf Maher Sulaiman, Ali Saeed Abdulaziz, Amina Mohamed Almutawea, Sarà, A. Alansari, Fatema Mohamed Aldoseri, Salma A. Bekhit, -. SalwaMutlaqAl, Thawadi, S. Alqallaf, A. Bekhit","doi":"10.33263/lianbs122.044","DOIUrl":"https://doi.org/10.33263/lianbs122.044","url":null,"abstract":"Warnings by WHO concerning the antibacterial resistance was an encouragement to investigate the antibacterial effects of extracted and purchased Salvia officinalis essential oils against S. aureus, L. monocytogenes, S. pyogenes, E. coli, P. aeruginosa, and K. pneumonia by the agar well diffusion method. Besides, the checkerboard method evaluated the potential synergistic antibacterial activity of volatile sage oil and meropenem against multi-drug resistant E. coli. Results showed that the purchased oil did not have antimicrobial activity against any of the tested pathogens, while the extracted oil of S. officinalis inhibited the growth of all the tested microorganisms except the MDR K. pneumonia. The extracted oil showed the highest activity against the E. coli with an IZ of 18±0.4 mm and MIC of 6.25± 0.2 mg/ml, and the lowest activity was recorded against P. aeruginosa with an IZ of 10±0.2 mm and MIC of 25 mg/ml. In addition, SoEO showed a promising synergistic effect with meropenem against MDR E. coli. Results suggest that the EOs of S. officinalis possess antimicrobial activity, and therefore, they can be used to treat infections caused by some pathogens.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86814981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Machrumnizar Machrumnizar, Suriyani Tan, Y. Yuliana
Sugary foods and beverages are highly consumed by children. It is a substrate for fungal growth and has effects on oral hygiene. The study aimed to determine sugary foods and beverages’ relationship to oral fungi and hygiene. This cross-sectional study was conducted on 150 students aged 11-12 years old, selected based on inclusive-exclusive criteria. Demographic data and sugary foods and beverages consumption were recorded in a questionnaire. The oral material was collected and cultured in SDA media. Fungal growth was evaluated microscopically, and then fungal identification used the Integral System YEASTS Plus (Liofilchem®). OHI was used to assess oral hygiene. Results showed that 72.0% were 12 years old, the frequency of sugary foods and beverages consumption was more than once per week in 85 children (56.67 %), mostly girls (30.9%). The fungus found was mostly Candida (55.3%), and 43.3% of children had poor oral hygiene. Statistical analysis showed a significant association between the frequency of sugary foods and beverages consumption with fungal colonization (p<0.05) and oral hygiene (p<0.05). The correlation between fungal colonization and oral hygiene was statistically significant (p<0.05). This study provides insight into the relationships between sugary foods and beverages, fungal colonization, and oral hygiene.
含糖食品和饮料是儿童大量消费的。它是真菌生长的基质，对口腔卫生有影响。这项研究旨在确定含糖食品和饮料与口腔真菌和卫生的关系。本横断面研究是对150名11-12岁的学生进行的，他们是根据包容性-排他性标准选择的。人口统计数据和含糖食品和饮料的消费记录在问卷中。收集口腔材料，用SDA培养基培养。在显微镜下评估真菌生长情况，然后使用Integral System yests Plus (Liofilchem®)进行真菌鉴定。OHI用于评估口腔卫生。结果显示，年龄在12岁的儿童占72.0%，每周摄入含糖食品和饮料频率在1次以上的儿童85例(56.67%)，其中以女孩居多(30.9%)。检出的真菌以念珠菌为主(55.3%)，43.3%的儿童口腔卫生状况较差。统计分析表明，含糖食品和饮料的消费频率与真菌定植(p<0.05)和口腔卫生(p<0.05)有显著相关性。真菌定植与口腔卫生的相关性有统计学意义(p<0.05)。这项研究深入了解了含糖食物和饮料、真菌定植和口腔卫生之间的关系。
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