Iron (Fe) is the 4th most widespread element on Earth that constitutes a crucial player in geochemistry, biological processes, and industry as metal. The study of iron biomineralization is a well-recognized interdisciplinary area that has been growing over the years. This paper presents an overview of iron-sponges interrelation, particularly from the view of nanostructured biocomposites. This review highlights the potential mechanism of iron-sponge interrelations, including biocorrosion as well as the possible role of selected amino acids and structural proteins in the mineralization process concerning the development of novel nanoorganized hybrid materials. This is the first review that describes the interrelations between iron and structural biopolymers of marine sponge skeletons to the best of our knowledge. We believe that this review will highlight new perspectives in bioinspired materials science and modern biomimetics.
{"title":"Iron-sponges Interrelations: from Biocorrosion to Nanostructured Biocomposites","authors":"","doi":"10.33263/lianbs123.064","DOIUrl":"https://doi.org/10.33263/lianbs123.064","url":null,"abstract":"Iron (Fe) is the 4th most widespread element on Earth that constitutes a crucial player in geochemistry, biological processes, and industry as metal. The study of iron biomineralization is a well-recognized interdisciplinary area that has been growing over the years. This paper presents an overview of iron-sponges interrelation, particularly from the view of nanostructured biocomposites. This review highlights the potential mechanism of iron-sponge interrelations, including biocorrosion as well as the possible role of selected amino acids and structural proteins in the mineralization process concerning the development of novel nanoorganized hybrid materials. This is the first review that describes the interrelations between iron and structural biopolymers of marine sponge skeletons to the best of our knowledge. We believe that this review will highlight new perspectives in bioinspired materials science and modern biomimetics.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81759968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study investigated the effects of the alkaloid fraction of Vitex doniana on liver and kidney functions in albino rats. A solution of CCl4 in paraffin (1:1) was used to induce liver damage in albino rats. The liver and kidney function tests were carried out by oral administration of varying doses (200, 400, and 600 mg/kg) of the bulk alkaloid to different groups of albino rats for 14 days. The rats were subsequently sacrificed, and the hepatocurative and histopathological assessment of the liver and kidney were carried out to determine the serum albumin, total protein, cholesterol (CHOL), triglycerides (TAG), low-density lipoproteins (LDLs), high-density lipoproteins (HDLs), blood urea nitrogen (BUN) and creatinine. The total protein, serum albumin, and HDLs were significantly (p < 0.05) increased by alkaloid fraction of V. doniana to values compared with the control. The results also showed that serum CHOL, TAG, LDLs, BUN, and creatinine were significantly reduced (p < 0.05) in rats treated with alkaloid fraction compared with untreated. The normal cellular architecture of the liver destroyed by the standard hepatotoxin was restored by the alkaloids. The alkaloids of V. doniana reverse the CCl4-induced hepatocellular damage, supporting its use in managing liver-associated diseases.
{"title":"Hepatocurative and Histopathological Evaluations in Albino Rats Exposed to Vitex Doniana Alkaloids","authors":"","doi":"10.33263/lianbs122.056","DOIUrl":"https://doi.org/10.33263/lianbs122.056","url":null,"abstract":"The study investigated the effects of the alkaloid fraction of Vitex doniana on liver and kidney functions in albino rats. A solution of CCl4 in paraffin (1:1) was used to induce liver damage in albino rats. The liver and kidney function tests were carried out by oral administration of varying doses (200, 400, and 600 mg/kg) of the bulk alkaloid to different groups of albino rats for 14 days. The rats were subsequently sacrificed, and the hepatocurative and histopathological assessment of the liver and kidney were carried out to determine the serum albumin, total protein, cholesterol (CHOL), triglycerides (TAG), low-density lipoproteins (LDLs), high-density lipoproteins (HDLs), blood urea nitrogen (BUN) and creatinine. The total protein, serum albumin, and HDLs were significantly (p < 0.05) increased by alkaloid fraction of V. doniana to values compared with the control. The results also showed that serum CHOL, TAG, LDLs, BUN, and creatinine were significantly reduced (p < 0.05) in rats treated with alkaloid fraction compared with untreated. The normal cellular architecture of the liver destroyed by the standard hepatotoxin was restored by the alkaloids. The alkaloids of V. doniana reverse the CCl4-induced hepatocellular damage, supporting its use in managing liver-associated diseases.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86159936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present work aimed to dye silk fabric with natural dye extracted from the Artemisia Herba Alba plant from its leaves on pure silk dyeing fabrics with different dyeing conditions such as time, temperature, and pH value in the presence of Alum as a mordant, which had given different colors and shades to promote the use of natural silk fiber. Optimum results were obtained. Silk fabric was dyed using pH 5 for 45 minutes at temperature 80oC and 1:40 liquor ratio. Finally, the dyed mordant samples were thoroughly washed and dried at ambient conditions. The results obtained us successfully characterized dyed silk fabric by studying with a Fourier Transform Infrared thermogravimetric (TGA) properties, (FTIR) analysis technique, and X-ray diffraction (XRD). Improvement in the dyeing process may have been attributed to the improvement in the molecular structure of the chemical bonds in silk fabrics. This work gives an opportunity to use a new traditional natural dye that meets the future environmental technology that exhibited fantastic dyed patterns of high quality.
{"title":"Investigation of Thermal and Structure Properties of Silk Dyed with a Natural Dye","authors":"R. Mahmoud, Nabawia A. Adelzaher","doi":"10.33263/lianbs122.060","DOIUrl":"https://doi.org/10.33263/lianbs122.060","url":null,"abstract":"The present work aimed to dye silk fabric with natural dye extracted from the Artemisia Herba Alba plant from its leaves on pure silk dyeing fabrics with different dyeing conditions such as time, temperature, and pH value in the presence of Alum as a mordant, which had given different colors and shades to promote the use of natural silk fiber. Optimum results were obtained. Silk fabric was dyed using pH 5 for 45 minutes at temperature 80oC and 1:40 liquor ratio. Finally, the dyed mordant samples were thoroughly washed and dried at ambient conditions. The results obtained us successfully characterized dyed silk fabric by studying with a Fourier Transform Infrared thermogravimetric (TGA) properties, (FTIR) analysis technique, and X-ray diffraction (XRD). Improvement in the dyeing process may have been attributed to the improvement in the molecular structure of the chemical bonds in silk fabrics. This work gives an opportunity to use a new traditional natural dye that meets the future environmental technology that exhibited fantastic dyed patterns of high quality.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87118894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Alberto Márquez-Montes, J. Gallegos‐Infante, Guillermo Rodrigo, Petzold-Maldonado, Patricio Orellana-Palma, R. González-Laredo, Nuria, Elizabeth Rocha-Guzmán, L. A. Ochoa-Martínez
Centrifugal cryoconcentration has been shown to be effective in the desalination of seawater, concentration of proteins, and liquid foods, mainly fruit juices; in the latter, it is particularly interesting to be a non-destructive technology on various bioactive compounds, such as polyphenols, which have been found in several fruit juices such as prickly pear. An important issue is related to centrifugation's effect on the concentration efficiency of cryoconcentration. The present work's main objective was to study the Block cryoconcentration assisted by centrifugation (BCCC), their effects on the polyphenols, and antioxidant activity applied to prickly pear juice. Prickly pear juice was obtained, Bx, pH, titratable acidity, color, total reducing sugars, total phenolic content (TPC), flavonoids, FRAP, DPPH, and process parameters (efficiency (η), concentration index (CI), and solute yield (Y)) were evaluated. Data obtained for physicochemical parameters showed high values of °Bx in cryoconcentrated samples, pH values decreased in treated samples, and total titratable acidity increased, total reducing sugars were higher in samples treated at the lower time of centrifugation, all experimental samples showed noticeable color changes. Higher total phenolic and flavonoid content were observed in samples treated at 15 min of centrifugation; DPPH and FRAP tests were highly correlated with TPC and flavonoid content (R2> 0.96). High efficiency and concentration index were observed; however, a low value of solute yield was found in cryoconcentrated juice. The use of cryoconcentration for prickly pear juices shows good results for physicochemical parameters, preservation of bioactive, and process parameters with the exception of solute yield.
{"title":"Centrifugal Cryoconcentration of Prickly Pear Juice: Effect on the Polyphenolic Content and their Antioxidant Activity","authors":"Carlos Alberto Márquez-Montes, J. Gallegos‐Infante, Guillermo Rodrigo, Petzold-Maldonado, Patricio Orellana-Palma, R. González-Laredo, Nuria, Elizabeth Rocha-Guzmán, L. A. Ochoa-Martínez","doi":"10.33263/lianbs122.057","DOIUrl":"https://doi.org/10.33263/lianbs122.057","url":null,"abstract":"Centrifugal cryoconcentration has been shown to be effective in the desalination of seawater, concentration of proteins, and liquid foods, mainly fruit juices; in the latter, it is particularly interesting to be a non-destructive technology on various bioactive compounds, such as polyphenols, which have been found in several fruit juices such as prickly pear. An important issue is related to centrifugation's effect on the concentration efficiency of cryoconcentration. The present work's main objective was to study the Block cryoconcentration assisted by centrifugation (BCCC), their effects on the polyphenols, and antioxidant activity applied to prickly pear juice. Prickly pear juice was obtained, Bx, pH, titratable acidity, color, total reducing sugars, total phenolic content (TPC), flavonoids, FRAP, DPPH, and process parameters (efficiency (η), concentration index (CI), and solute yield (Y)) were evaluated. Data obtained for physicochemical parameters showed high values of °Bx in cryoconcentrated samples, pH values decreased in treated samples, and total titratable acidity increased, total reducing sugars were higher in samples treated at the lower time of centrifugation, all experimental samples showed noticeable color changes. Higher total phenolic and flavonoid content were observed in samples treated at 15 min of centrifugation; DPPH and FRAP tests were highly correlated with TPC and flavonoid content (R2> 0.96). High efficiency and concentration index were observed; however, a low value of solute yield was found in cryoconcentrated juice. The use of cryoconcentration for prickly pear juices shows good results for physicochemical parameters, preservation of bioactive, and process parameters with the exception of solute yield.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90818632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marwaa M. Abd-El Monem, A. A. El-Megeid, Eman F. El-Haggar
Implantation Ras cheese with different vegetable oils as a ketogenic model in the form to use it as a diet plan to prevent obesity and investigated cytotoxicity mode of these vegetable oils on liver cancer as consequences of obesity complications in vitro system by using Huh7 cell line. The chemical and organoleptic characteristics of Ras cheese with different vegetable oils were investigated, as well as phenolic compounds and fatty acid profiles of these oils were identified and determined. Thus, findings show that the Ras cheese with different oil possesses different omega fatty acid ratios, including omega 3, 6, and 9. The total phenolic compound results indicate that sesame oil had a pronounced rank of kaempferol (2478.44 µg/g) content, followed by canola oil (628.15 µg/g). Also, peanuts oil contains the highest value of gallic acid (164.52 µg/g), while canola oil is alone contains hesperetin value (793.44 µg/g). Ras cheese with canola oil had the highest protein and fat contents compared to other Ras cheese treatments. The results showed that Ras cheese with canola and sesame oil had a pivotal role in cancer cells. It is also considered a functional dairy product that may offer vital nutrients and health benefits.
{"title":"Ras Cheese with Different Omega Fatty Acids as Diet Plans: Cytotoxicity & Characteristics","authors":"Marwaa M. Abd-El Monem, A. A. El-Megeid, Eman F. El-Haggar","doi":"10.33263/lianbs122.055","DOIUrl":"https://doi.org/10.33263/lianbs122.055","url":null,"abstract":"Implantation Ras cheese with different vegetable oils as a ketogenic model in the form to use it as a diet plan to prevent obesity and investigated cytotoxicity mode of these vegetable oils on liver cancer as consequences of obesity complications in vitro system by using Huh7 cell line. The chemical and organoleptic characteristics of Ras cheese with different vegetable oils were investigated, as well as phenolic compounds and fatty acid profiles of these oils were identified and determined. Thus, findings show that the Ras cheese with different oil possesses different omega fatty acid ratios, including omega 3, 6, and 9. The total phenolic compound results indicate that sesame oil had a pronounced rank of kaempferol (2478.44 µg/g) content, followed by canola oil (628.15 µg/g). Also, peanuts oil contains the highest value of gallic acid (164.52 µg/g), while canola oil is alone contains hesperetin value (793.44 µg/g). Ras cheese with canola oil had the highest protein and fat contents compared to other Ras cheese treatments. The results showed that Ras cheese with canola and sesame oil had a pivotal role in cancer cells. It is also considered a functional dairy product that may offer vital nutrients and health benefits.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88257070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanoparticles (NPs) are playing a significant role in the development of modern agriculture. Among other metal nanoparticles, ZnS NPs are important due to their utilization in agriculture. Zinc sulfide nanoparticles have great potential to enhance agriculture production. The co-precipitation method was used to make ZnS nanoparticles, and morphological features were investigated using X-ray diffraction (XRD) and a transmission electron microscope (TEM) to determine size. The average particle was near ~3 nm calculated using XRD, close to the TEM study. Tomatoes, which belong to the Solanaceae family, are one of India's most important vegetable crops. The tomato plants were sprayed with a graded concentration of zinc sulfide nanoparticles (ZnS NPs) based nano-fertilizer four times at a 15-day interval and a control. At the flowering time, growth parameters such as plant height were measured. Nanofertilizer-treated plants showed increased weight and quality of crop yield. This paper elaborates the synthesis, characterization, properties, and application of ZnS NPs as nano-fertilizer on tomato plant growth. Developing nano-based fertilizer would be a new technique in this field, as nano-fertilizers are beneficial and less toxic to chemical fertilizer and improve soil fertility.
{"title":"Agricultural Application of Synthesized ZnS Nanoparticles for the Development of Tomato Crop","authors":"","doi":"10.33263/lianbs122.058","DOIUrl":"https://doi.org/10.33263/lianbs122.058","url":null,"abstract":"Nanoparticles (NPs) are playing a significant role in the development of modern agriculture. Among other metal nanoparticles, ZnS NPs are important due to their utilization in agriculture. Zinc sulfide nanoparticles have great potential to enhance agriculture production. The co-precipitation method was used to make ZnS nanoparticles, and morphological features were investigated using X-ray diffraction (XRD) and a transmission electron microscope (TEM) to determine size. The average particle was near ~3 nm calculated using XRD, close to the TEM study. Tomatoes, which belong to the Solanaceae family, are one of India's most important vegetable crops. The tomato plants were sprayed with a graded concentration of zinc sulfide nanoparticles (ZnS NPs) based nano-fertilizer four times at a 15-day interval and a control. At the flowering time, growth parameters such as plant height were measured. Nanofertilizer-treated plants showed increased weight and quality of crop yield. This paper elaborates the synthesis, characterization, properties, and application of ZnS NPs as nano-fertilizer on tomato plant growth. Developing nano-based fertilizer would be a new technique in this field, as nano-fertilizers are beneficial and less toxic to chemical fertilizer and improve soil fertility.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75673518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emerging nanotechnology has a significant impact on diverse fields such as medical, information technology, energy, advanced materials, textile, and many new upcoming areas. Out of all methods to produce nanoparticles, the green synthesis is the best one as it is cost-effective, non-toxic in nature, simple at feasible conditions. In our study, we are fabricating silver nanoparticles by a single-step green synthesis method using the water extract of the leaves of the Vitex negundo plant. The plant is well known for its rich supply of biologically active compounds. The plant consists of flavonoids, polyphenols, terpenoids, and many more metabolite compounds that are used to prevent many diseases. These help as a capping agent and stabilizing agent in the process of forming silver nanoparticles from silver nitrate solution. Thus, fabricated silver nanoparticles are subjected to characterization techniques such as UV-Visible spectroscopy, FTIR, DLS, SEM with EDX, and XRD to determine silver nanoparticles' size, structure, and shape. Further, the antimicrobial activity of these silver nanoparticles is evaluated against four bacterial strains. Two of them are gram-positive, and the other two are gram-negative. The gram-positive bacteria, namely M. luteus and B. subtilis have shown good activity compared to gram-negative bacteria, namely E. coli and Salmonella. typhi.
{"title":"Synthesis of Silver Nanoparticles from Vitex negundo Plant by Green Method and their Bactericidal Effects","authors":"","doi":"10.33263/lianbs122.059","DOIUrl":"https://doi.org/10.33263/lianbs122.059","url":null,"abstract":"Emerging nanotechnology has a significant impact on diverse fields such as medical, information technology, energy, advanced materials, textile, and many new upcoming areas. Out of all methods to produce nanoparticles, the green synthesis is the best one as it is cost-effective, non-toxic in nature, simple at feasible conditions. In our study, we are fabricating silver nanoparticles by a single-step green synthesis method using the water extract of the leaves of the Vitex negundo plant. The plant is well known for its rich supply of biologically active compounds. The plant consists of flavonoids, polyphenols, terpenoids, and many more metabolite compounds that are used to prevent many diseases. These help as a capping agent and stabilizing agent in the process of forming silver nanoparticles from silver nitrate solution. Thus, fabricated silver nanoparticles are subjected to characterization techniques such as UV-Visible spectroscopy, FTIR, DLS, SEM with EDX, and XRD to determine silver nanoparticles' size, structure, and shape. Further, the antimicrobial activity of these silver nanoparticles is evaluated against four bacterial strains. Two of them are gram-positive, and the other two are gram-negative. The gram-positive bacteria, namely M. luteus and B. subtilis have shown good activity compared to gram-negative bacteria, namely E. coli and Salmonella. typhi.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86303566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Honnegowdanahalli, Shivabasappa, Nagendra, Prasad, Navyatha, Prashanth, Gaonkar, Agasanapura Puttaswamy Ananda, Amogh Mukarambi, Guddappa Charan Kumar, T. N. Lohith, Hampapura Sunderraj Jayanth, Nidaghatta Beeregowda, Krishnamurthy, M. A. Sridhar, P. Mallu
In this investigation, Schiff-based Piperazine was synthesized characterized with different spectral studies. Synthesized compound was subjected to Density functional theory (DFT), Adsorption, Distribution, Metabolism and Excretion (ADME), Blood-Brain Barrier (BBB), and their prediction of activity spectra of computational screening (PASS) for their application in the biological science was predicted, drug-likeness and total surface area was calculated. Membrane disassembly was studied based on the fatty acid profile test, compound exhibit potent in vitro biocidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) at 30±0.45µg/mL. The membrane damage property was validated by SEM analysis; then, the fatty acid profile test addressed membrane disassembly. The synthesized compound shows significant activity in the fatty acid profile test. It confirms involvement in the membrane disassembly of MRSA. Molecular docking approach for the validation for understanding membrane damage and miss loading of FMM. This work suggests that Schiff-based piperazine is a potent antibacterial candidate against MRSA.
{"title":"Antibacterial Property of Schiff-based Piperazine against MRSA: Design, Synthesis, Molecular Docking, and DFT Computational Studies","authors":"Honnegowdanahalli, Shivabasappa, Nagendra, Prasad, Navyatha, Prashanth, Gaonkar, Agasanapura Puttaswamy Ananda, Amogh Mukarambi, Guddappa Charan Kumar, T. N. Lohith, Hampapura Sunderraj Jayanth, Nidaghatta Beeregowda, Krishnamurthy, M. A. Sridhar, P. Mallu","doi":"10.33263/lianbs122.054","DOIUrl":"https://doi.org/10.33263/lianbs122.054","url":null,"abstract":"In this investigation, Schiff-based Piperazine was synthesized characterized with different spectral studies. Synthesized compound was subjected to Density functional theory (DFT), Adsorption, Distribution, Metabolism and Excretion (ADME), Blood-Brain Barrier (BBB), and their prediction of activity spectra of computational screening (PASS) for their application in the biological science was predicted, drug-likeness and total surface area was calculated. Membrane disassembly was studied based on the fatty acid profile test, compound exhibit potent in vitro biocidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) at 30±0.45µg/mL. The membrane damage property was validated by SEM analysis; then, the fatty acid profile test addressed membrane disassembly. The synthesized compound shows significant activity in the fatty acid profile test. It confirms involvement in the membrane disassembly of MRSA. Molecular docking approach for the validation for understanding membrane damage and miss loading of FMM. This work suggests that Schiff-based piperazine is a potent antibacterial candidate against MRSA.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88823328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sri Gustini Husein, Syarif Hamdani, Kardian Rinaldi
Ar-turmerone is one of the curcumin derivatives contained in turmeric oleoresins. Ar-turmerone has various pharmacological effects, including antivenom, antidepressant, antiepileptic, antidermatophyte, antitumor, and antiplatelet activity. This research aimed to develop an isolation method of ar-turmerone from turmeric oleoresin using silica gel adsorbent, which is relatively low cost. Ar-turmerone was isolated by adsorption process using silica gel adsorbent and followed by elution process using a suitable solvent. The UV-visible spectrum of the isolated compounds showed a maximum wavelength at 237 nm. FTIR spectrum values were found at 2300 cm-1 and 2935 cm-1 (for aromatic C=C stretching), 1445 cm-1 and 1735 cm-1 (for C=O stretching), and 990 cm-1 and 1100 cm-1 (for C–H bending). GC-MS spectrum showed a main peak at a retention time of 12.884 minutes and a percent area of 27.74%, which was identified as ar-turmerone (molecular weight of 216). The optimum condition for the isolation of ar-turmerone from turmeric oleoresin using silica gel as adsorbent was the use of turmeric oleoresin:silica gel with a ratio of 1:3 without being affected by adsorption time. The optimum eluent for the elution process was 96% ethanol.
{"title":"Optimization of ar-Turmerone Isolation Method from Turmeric Oleoresin using Silica Gel Adsorbent","authors":"Sri Gustini Husein, Syarif Hamdani, Kardian Rinaldi","doi":"10.33263/lianbs122.053","DOIUrl":"https://doi.org/10.33263/lianbs122.053","url":null,"abstract":"Ar-turmerone is one of the curcumin derivatives contained in turmeric oleoresins. Ar-turmerone has various pharmacological effects, including antivenom, antidepressant, antiepileptic, antidermatophyte, antitumor, and antiplatelet activity. This research aimed to develop an isolation method of ar-turmerone from turmeric oleoresin using silica gel adsorbent, which is relatively low cost. Ar-turmerone was isolated by adsorption process using silica gel adsorbent and followed by elution process using a suitable solvent. The UV-visible spectrum of the isolated compounds showed a maximum wavelength at 237 nm. FTIR spectrum values were found at 2300 cm-1 and 2935 cm-1 (for aromatic C=C stretching), 1445 cm-1 and 1735 cm-1 (for C=O stretching), and 990 cm-1 and 1100 cm-1 (for C–H bending). GC-MS spectrum showed a main peak at a retention time of 12.884 minutes and a percent area of 27.74%, which was identified as ar-turmerone (molecular weight of 216). The optimum condition for the isolation of ar-turmerone from turmeric oleoresin using silica gel as adsorbent was the use of turmeric oleoresin:silica gel with a ratio of 1:3 without being affected by adsorption time. The optimum eluent for the elution process was 96% ethanol.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"239 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72918873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harsimaran Kaur, N. Chakraborty, K. C. Juglan, Parminder Kaur, Harsh, Kumar
The density and speed of sound for polyethylene glycols (PEG-200 and PEG-600) in an aqueous solution of D-Mannitol have been measured by Anton Paar DSA 5000M at different temperatures and concentrations. Experimentally obtained data of density and speed of sound are employed to calculate various theoretical parameters such as intermolecular free length, acoustic impedance, adiabatic compressibility, Wada's constant, Rao's Constant, and Vander Waal's constant, which gave the better insight into molecular interactions between the polyethylene glycols and D-mannitol solutions.
用Anton Paar DSA 5000M测量了聚乙二醇(PEG-200和PEG-600)在不同温度和浓度下在d -甘露醇水溶液中的密度和声速。利用实验得到的密度和声速数据，计算了分子间自由长度、声阻抗、绝热压缩系数、Wada常数、Rao常数和Vander Waal常数等理论参数，从而更好地了解聚乙二醇与d -甘露醇溶液之间的分子相互作用。
{"title":"Study of Molecular Interaction of PEG-200 and PEG-600 in Aqueous D-Mannitol Solutions at Different Temperatures","authors":"Harsimaran Kaur, N. Chakraborty, K. C. Juglan, Parminder Kaur, Harsh, Kumar","doi":"10.33263/lianbs122.052","DOIUrl":"https://doi.org/10.33263/lianbs122.052","url":null,"abstract":"The density and speed of sound for polyethylene glycols (PEG-200 and PEG-600) in an aqueous solution of D-Mannitol have been measured by Anton Paar DSA 5000M at different temperatures and concentrations. Experimentally obtained data of density and speed of sound are employed to calculate various theoretical parameters such as intermolecular free length, acoustic impedance, adiabatic compressibility, Wada's constant, Rao's Constant, and Vander Waal's constant, which gave the better insight into molecular interactions between the polyethylene glycols and D-mannitol solutions.","PeriodicalId":18009,"journal":{"name":"Letters in Applied NanoBioScience","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81403068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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