S. Zununi Vahed, S. Naderi, S. M. Hejazian, Abdolmohammad Ranjbar, E. Ahmadian, M. Tarzamani, M. Ardalan
Background. The prevalence of chronic kidney disease (CKD) is increasing every year, which increases the risk of cardiovascular disease and even death. In Cardiorenal syndrome type 2 (CRS2), chronic cardiac dysfunction causes renal dysfunction. The aim of this study was to evaluate Doppler ultrasound of renal veins, calculate venous impedance index (VII) and determine their associations with the prognosis of CRS2 syndrome in patients with a history of chronic heart disease and CKD with a good forward function. Methods. In this descriptive-analytical study, 49 patients referred to Imam Reza Hospital in Tabriz with heart failure and renal dysfunction were selected. Renal status, VII and ejection fraction (EF) were evaluated. Results. Mean age of the patients was 61.83±12.39 years, 42.9% of which were women and 57.1% were men. The durations of heart and renal failure were 33.16 ± 13.8 and 11.76±5.1 months, respectively. Significant associations were found between VII and EF of the right and left kidneys (P=0.01 and P =0.03, respectively). But there was no statistically significant relationship between renal function and EF (P =0.54). With increasing edema rate, both VII and EF were decreased; however, these associations were not statistically significant (P >0.05). Conclusion. According to the results, significant associations were found between VII and EF of right and left kidneys, however, no statistically significant correlations were observed between edema and VII mean and EF.
{"title":"Venous impedance index and its relation with renal outcomes in patients with heart failure and renal dysfunction","authors":"S. Zununi Vahed, S. Naderi, S. M. Hejazian, Abdolmohammad Ranjbar, E. Ahmadian, M. Tarzamani, M. Ardalan","doi":"10.34172/mj.2022.001","DOIUrl":"https://doi.org/10.34172/mj.2022.001","url":null,"abstract":"Background. The prevalence of chronic kidney disease (CKD) is increasing every year, which increases the risk of cardiovascular disease and even death. In Cardiorenal syndrome type 2 (CRS2), chronic cardiac dysfunction causes renal dysfunction. The aim of this study was to evaluate Doppler ultrasound of renal veins, calculate venous impedance index (VII) and determine their associations with the prognosis of CRS2 syndrome in patients with a history of chronic heart disease and CKD with a good forward function. Methods. In this descriptive-analytical study, 49 patients referred to Imam Reza Hospital in Tabriz with heart failure and renal dysfunction were selected. Renal status, VII and ejection fraction (EF) were evaluated. Results. Mean age of the patients was 61.83±12.39 years, 42.9% of which were women and 57.1% were men. The durations of heart and renal failure were 33.16 ± 13.8 and 11.76±5.1 months, respectively. Significant associations were found between VII and EF of the right and left kidneys (P=0.01 and P =0.03, respectively). But there was no statistically significant relationship between renal function and EF (P =0.54). With increasing edema rate, both VII and EF were decreased; however, these associations were not statistically significant (P >0.05). Conclusion. According to the results, significant associations were found between VII and EF of right and left kidneys, however, no statistically significant correlations were observed between edema and VII mean and EF.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79913910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Amini-khoei, Shakiba Nasiri Boroujeni, Z. Lorigooini, Sepideh Yadollahi, Seyyed Kamal Solati Dehkordi, Mahmoud Rafieian Koopai
Background. Epilepsy is one of the most common neurological disorders after stroke. Due to the side effects and poor response of conventional anticonvulsant drugs, researchers have turned their attention to find new drugs. Carvacrol is a phenolic compound with neuroprotective, anti-inflammatory, antioxidant and anticonvulsant effects. The aim of the study was to investigate the anticonvulsant effects of carvacrol in PTZ-induced seizures in male mice and to investigate the role of N-Methyl-D-Aspartic Acid (NMDA) receptor. Methods. In the present experimental study, 90 mice were randomly divided into 9 groups (n=10). Drugs were injected intraperitoneally 30 minutes before PTZ injection. Then, seizure onset time, serum and brain antioxidant capacity (TAC) and malondialdehyde (MDA) and NMDA receptor gene expression in the hippocampus were examined. Results. Seizure onset time in the group received carvacrol (20 and 40 mg/kg) was significantly longer than the PTZ group (P<0.05). Treatment with carvacrol (20 and 40 mg/kg) significantly increased serum and brain antioxidant capacity and reduced serum and brain MDA in compared to the PTZ group (at doses of 5, 10, 20 and 40 mg/kg). The expression of NR2A and NR2B subunits of hippocampal NMDA receptors in carvacrol-received mice was significantly lower than the PTZ group (P<0.05). Conclusion. Carvacrol has anticonvulsant effects, possibly by inhibiting oxidative stress and reducing the expression of subunits of NMDA receptors.
背景。癫痫是中风后最常见的神经系统疾病之一。由于常规抗惊厥药物的副作用和不良反应，研究人员已将注意力转向寻找新的药物。香芹酚是一种酚类化合物，具有神经保护、抗炎、抗氧化和抗惊厥作用。本研究旨在探讨香芹酚对ptz诱导的雄性小鼠癫痫发作的抗惊厥作用，并探讨n -甲基- d -天冬氨酸(NMDA)受体的作用。方法。在本实验研究中，90只小鼠随机分为9组(n=10)。药物于PTZ注射前30分钟腹腔注射。然后检测癫痫发作时间、血清和脑抗氧化能力(TAC)、海马丙二醛(MDA)和NMDA受体基因表达。结果。卡伐克罗(20、40 mg/kg)组癫痫发作时间明显长于PTZ组(P<0.05)。与PTZ组(剂量为5、10、20和40 mg/kg)相比，carvacrol(20和40 mg/kg)显著提高了血清和脑抗氧化能力，降低了血清和脑MDA。carvacrol组小鼠海马NMDA受体NR2A、NR2B亚基表达量显著低于PTZ组(P<0.05)。结论。香芹酚具有抗惊厥作用，可能是通过抑制氧化应激和减少NMDA受体亚基的表达。
{"title":"Evaluation of the anticonvulsant effect of carvacrol in Pentylenetetrazole (PTZ)-induced seizures in male mice: N-Methyl-D-Aspartic Acid receptor role","authors":"H. Amini-khoei, Shakiba Nasiri Boroujeni, Z. Lorigooini, Sepideh Yadollahi, Seyyed Kamal Solati Dehkordi, Mahmoud Rafieian Koopai","doi":"10.34172/mj.2022.004","DOIUrl":"https://doi.org/10.34172/mj.2022.004","url":null,"abstract":"Background. Epilepsy is one of the most common neurological disorders after stroke. Due to the side effects and poor response of conventional anticonvulsant drugs, researchers have turned their attention to find new drugs. Carvacrol is a phenolic compound with neuroprotective, anti-inflammatory, antioxidant and anticonvulsant effects. The aim of the study was to investigate the anticonvulsant effects of carvacrol in PTZ-induced seizures in male mice and to investigate the role of N-Methyl-D-Aspartic Acid (NMDA) receptor. Methods. In the present experimental study, 90 mice were randomly divided into 9 groups (n=10). Drugs were injected intraperitoneally 30 minutes before PTZ injection. Then, seizure onset time, serum and brain antioxidant capacity (TAC) and malondialdehyde (MDA) and NMDA receptor gene expression in the hippocampus were examined. Results. Seizure onset time in the group received carvacrol (20 and 40 mg/kg) was significantly longer than the PTZ group (P<0.05). Treatment with carvacrol (20 and 40 mg/kg) significantly increased serum and brain antioxidant capacity and reduced serum and brain MDA in compared to the PTZ group (at doses of 5, 10, 20 and 40 mg/kg). The expression of NR2A and NR2B subunits of hippocampal NMDA receptors in carvacrol-received mice was significantly lower than the PTZ group (P<0.05). Conclusion. Carvacrol has anticonvulsant effects, possibly by inhibiting oxidative stress and reducing the expression of subunits of NMDA receptors.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77321903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. M. Razavi, L. Maleki, B. Tahani, A. Behzadian, Hamed Rabbani, Zahra Ravankhah
Background. Clinical and pathologic features of oral and maxillofacial malignant lesions are very important and useful in diagnostic and therapeutic planning. The aim of this study was to determine and compare the clinicopathologic features of different types of oral and maxillofacial cancers in Cancer Registry System at Isfahan-Iran. Methods. In this cross-sectional descriptive analytic study, required data (tumor type, tumor location, age, sex, and grade of malignancy) of 1081 patients from Isfahan Cancer Registry collected. Results. In this study, the mean age of the patients was 59.9±18.5years old. Most of the patients were male (56.43%). In this study, squamous cell carcinoma was the most common malignancy (61.9%) followed by non-Hodgkin's lymphoma (7%). The most common site was tongue (38.7%) and then the nasopharynx (13%). Also nasopharynx tumors in men were more common than women (P <0.001). Conclusion. Squamous cell carcinoma, as the most common oral and maxillofacial cancer, requires considerable attention and rapid and appropriate diagnosis and treatment. Knowing the clinical and pathological features of this cancer and risk factors can improve the prognosis of patients.
{"title":"Comparative study of clinicopathologic features of oral and maxillofacial cancers in Cancer Registry System (Isfahan-Iran)","authors":"S. M. Razavi, L. Maleki, B. Tahani, A. Behzadian, Hamed Rabbani, Zahra Ravankhah","doi":"10.34172/mj.2022.003","DOIUrl":"https://doi.org/10.34172/mj.2022.003","url":null,"abstract":"Background. Clinical and pathologic features of oral and maxillofacial malignant lesions are very important and useful in diagnostic and therapeutic planning. The aim of this study was to determine and compare the clinicopathologic features of different types of oral and maxillofacial cancers in Cancer Registry System at Isfahan-Iran. Methods. In this cross-sectional descriptive analytic study, required data (tumor type, tumor location, age, sex, and grade of malignancy) of 1081 patients from Isfahan Cancer Registry collected. Results. In this study, the mean age of the patients was 59.9±18.5years old. Most of the patients were male (56.43%). In this study, squamous cell carcinoma was the most common malignancy (61.9%) followed by non-Hodgkin's lymphoma (7%). The most common site was tongue (38.7%) and then the nasopharynx (13%). Also nasopharynx tumors in men were more common than women (P <0.001). Conclusion. Squamous cell carcinoma, as the most common oral and maxillofacial cancer, requires considerable attention and rapid and appropriate diagnosis and treatment. Knowing the clinical and pathological features of this cancer and risk factors can improve the prognosis of patients.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"132 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77764034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Mousavi, Mehrdad Ghaemmaghami, R. Alipour, Sona Rahimpour
I Restless legs syndrome (RLS), is a neurological disorder in which persons feel uncomfortable, especially at night, in the limbs and needs to move their legs. This condition worsens with rest. The aim of this study was to evaluate the frequency of restless legs syndrome in patients with renal insufficiency. In this case-control study, 180 patients with chronic kidney disease (90 hemodialysis patients and 90 non-dialysis patients) who referred to the nephrology clinic and dialysis ward of Imam Reza Hospital in Tabriz, were investigated. Data collection was done through a questionnaire form which was based on the criteria of the International Association for the Study of Restless Legs Syndrome. Among 180 patients in studied, 92 (51.7%) cases were male and 88 (48.3%) cases were female. The mean age of patients was 60.4 ± 17.2. So, 90 non-dialysis patients and 90 hemodialysis patients were evaluated. Of all the hemodialysis patients studied, 33 (37%) patients had restless legs syndrome, and among the non-dialysis patients, only 16 (18%) patients had restless legs syndrome. The frequency of restless legs syndrome is significantly higher in patients undergoing hemodialysis (P=0.001). There was also a meaningful difference about the frequency of restless legs syndrome among the male (77%) patients than females (23%) (P=0.001). A significant percentage (27%) of patients with renal failure suffer from restless legs syndrome and the hemodialysis patients are more involved in this disease, which needs more importance. Also, based on our findings in this study, men have a high probability of a conflict of restless legs syndrome than women
{"title":"The relationship between chronic kidney disease and restless legs syndrome and its effective factors. A case-control study.","authors":"Z. Mousavi, Mehrdad Ghaemmaghami, R. Alipour, Sona Rahimpour","doi":"10.34172/mj.2021.072","DOIUrl":"https://doi.org/10.34172/mj.2021.072","url":null,"abstract":"I Restless legs syndrome (RLS), is a neurological disorder in which persons feel uncomfortable, especially at night, in the limbs and needs to move their legs. This condition worsens with rest. The aim of this study was to evaluate the frequency of restless legs syndrome in patients with renal insufficiency. In this case-control study, 180 patients with chronic kidney disease (90 hemodialysis patients and 90 non-dialysis patients) who referred to the nephrology clinic and dialysis ward of Imam Reza Hospital in Tabriz, were investigated. Data collection was done through a questionnaire form which was based on the criteria of the International Association for the Study of Restless Legs Syndrome. Among 180 patients in studied, 92 (51.7%) cases were male and 88 (48.3%) cases were female. The mean age of patients was 60.4 ± 17.2. So, 90 non-dialysis patients and 90 hemodialysis patients were evaluated. Of all the hemodialysis patients studied, 33 (37%) patients had restless legs syndrome, and among the non-dialysis patients, only 16 (18%) patients had restless legs syndrome. The frequency of restless legs syndrome is significantly higher in patients undergoing hemodialysis (P=0.001). There was also a meaningful difference about the frequency of restless legs syndrome among the male (77%) patients than females (23%) (P=0.001). A significant percentage (27%) of patients with renal failure suffer from restless legs syndrome and the hemodialysis patients are more involved in this disease, which needs more importance. Also, based on our findings in this study, men have a high probability of a conflict of restless legs syndrome than women","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81032966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Gharehbaghi, Sadollah Yegane Dust, Elmira Naseri
Background. Prematurity is one of the major health problems and common causes of neonatal mortality. One of the complications of premature infants is hyponatremia. The effect of hyponatremia on the prognosis of preterm infants has not been well studied. This study aimed to evaluate infants with late hyponatremia, its risk factors, and prognosis. Methods. This descriptive analytical study reviewed preterm infants (<34 weeks) admitted to Al-Zahra or Children’s Hospital in Tabriz for one year (2019). Neonates diagnosed with hyponatremia after the second week were identified and evaluated for risk factors and short-term outcome. Results. A total of 186 neonates were studied. The mean gestational age of the neonates was 30 weeks (first and third quarters = 29-32 weeks). 101 (54.3%) infants were male. The route of delivery was the cesarean section in 60.7% of cases. Late hyponatremia was present in 50 (26.8 %) infants. Gestational age and birth weight were significantly lower in infants with hyponatremia than in the control group. Multivariate analysis showed that low birth weight, the use of prenatal steroids, and inappropriate weight for gestational age status independently predict the incidence of late hyponatremia. There was a significant relationship between the presence of prolonged late hyponatremia (over 7 days) and bronchopulmonary dysplasia and osteopenia of prematurity. However, no significant association was found between the presence of prolonged late hyponatremia in preterm infants with the length of hospital stay and in-hospital mortality. Conclusion. Based on the findings of this study, low birth weight, prenatal steroid use, and lack of appropriate weight for gestational age were risk factors for late hyponatremia in preterm infants. Prolonged hyponatremia is associated with bronchopulmonary dysplasia and osteopenia of prematurity
{"title":"Late hyponatremia: its risk factors in preterm infants and short-term outcome","authors":"M. Gharehbaghi, Sadollah Yegane Dust, Elmira Naseri","doi":"10.34172/mj.2021.069","DOIUrl":"https://doi.org/10.34172/mj.2021.069","url":null,"abstract":"Background. Prematurity is one of the major health problems and common causes of neonatal mortality. One of the complications of premature infants is hyponatremia. The effect of hyponatremia on the prognosis of preterm infants has not been well studied. This study aimed to evaluate infants with late hyponatremia, its risk factors, and prognosis. Methods. This descriptive analytical study reviewed preterm infants (<34 weeks) admitted to Al-Zahra or Children’s Hospital in Tabriz for one year (2019). Neonates diagnosed with hyponatremia after the second week were identified and evaluated for risk factors and short-term outcome. Results. A total of 186 neonates were studied. The mean gestational age of the neonates was 30 weeks (first and third quarters = 29-32 weeks). 101 (54.3%) infants were male. The route of delivery was the cesarean section in 60.7% of cases. Late hyponatremia was present in 50 (26.8 %) infants. Gestational age and birth weight were significantly lower in infants with hyponatremia than in the control group. Multivariate analysis showed that low birth weight, the use of prenatal steroids, and inappropriate weight for gestational age status independently predict the incidence of late hyponatremia. There was a significant relationship between the presence of prolonged late hyponatremia (over 7 days) and bronchopulmonary dysplasia and osteopenia of prematurity. However, no significant association was found between the presence of prolonged late hyponatremia in preterm infants with the length of hospital stay and in-hospital mortality. Conclusion. Based on the findings of this study, low birth weight, prenatal steroid use, and lack of appropriate weight for gestational age were risk factors for late hyponatremia in preterm infants. Prolonged hyponatremia is associated with bronchopulmonary dysplasia and osteopenia of prematurity","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89544570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. One of the most common childhood disorders is attention-deficit/hyperactivity disorder (ADHD). This study aimed to determine the prevalence of ADHD in children aged 6-11 years in Piranshahr city (Iran). Methods. This descriptive-analytical study involved six hundred primary school students (300 girls and 300 boys) in Piranshahr city who were enrolled in the study using stratified random sampling. The frequency of ADHD was assessed using the short form of the Conners Teacher and Parent Rating Scale. Results. The frequency of inattention and hyperactivity indices in girls were respectively 13% and 15%, per Conners Parents Rating Scale, and 14.6% and 16.6% per Conners Teacher Rating Scale, while the frequency of ADHD index was 6.33% and 8.66%, respectively. The frequency of inattention and hyperactivity indexes in boys were respectively 11% and 17% per Conners Teacher Rating Scale, and 20.6% and 24.6%, respectively, per Conners Parents Rating scale, whereas the frequency of ADHD index was based on parents and teacher was 5.6% and 18.3%, respectively. Conclusion. This study showed that the prevalence of children prone to ADHD in the Piranshahr region is relatively high in comparison with other regions of the country. Therefore, it is necessary to study this disorder in the identity card of children at the entrance to kindergartens and schools to identify the patients, so through timely and appropriate intervention, its important complications in adolescence and adulthood can be prevented.
{"title":"Frequency of Attention Deficit Hyperactivity Disorder (ADHD) in children aged 6-11 years old in the city of Piranshahr","authors":"Abdolkarim Piroti, S. Amiri, S. Tabatabaei","doi":"10.34172/mj.2021.068","DOIUrl":"https://doi.org/10.34172/mj.2021.068","url":null,"abstract":"Background. One of the most common childhood disorders is attention-deficit/hyperactivity disorder (ADHD). This study aimed to determine the prevalence of ADHD in children aged 6-11 years in Piranshahr city (Iran). Methods. This descriptive-analytical study involved six hundred primary school students (300 girls and 300 boys) in Piranshahr city who were enrolled in the study using stratified random sampling. The frequency of ADHD was assessed using the short form of the Conners Teacher and Parent Rating Scale. Results. The frequency of inattention and hyperactivity indices in girls were respectively 13% and 15%, per Conners Parents Rating Scale, and 14.6% and 16.6% per Conners Teacher Rating Scale, while the frequency of ADHD index was 6.33% and 8.66%, respectively. The frequency of inattention and hyperactivity indexes in boys were respectively 11% and 17% per Conners Teacher Rating Scale, and 20.6% and 24.6%, respectively, per Conners Parents Rating scale, whereas the frequency of ADHD index was based on parents and teacher was 5.6% and 18.3%, respectively. Conclusion. This study showed that the prevalence of children prone to ADHD in the Piranshahr region is relatively high in comparison with other regions of the country. Therefore, it is necessary to study this disorder in the identity card of children at the entrance to kindergartens and schools to identify the patients, so through timely and appropriate intervention, its important complications in adolescence and adulthood can be prevented.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78448020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. ERCP is the gold standard procedure for diagnosis and potential treatment of biliary-pancreatic disorders with various distributions in different areas of the world. The study aimed to evaluate the findings, outcome, complications and technical experiences of ERCP, also by considering the correlation of findings with liver function tests (LFT) and imaging. Methods. In this descriptive – cross sectional data-based study for 12 years from 2007, 626 (43.9% male and 56.1%female; mean age 60 Ys) consecutive patients were subjected with therapeutic purpose at two referral hospitals. Results. Epigastric pain (40%), jaundice (39.4%) and pruritus (38.1%) were the most common indications. CBD was cannulated by optimal wire- guided sphincterotomy in 486(77.6%) patients. Precut was performed in 65(10.6%) with successful cannulation in 61 cases (93.8%) and 7.7% of complications, including perforation. A total success rate of 98% was obtained. The most common diagnoses were CBD stone(s) in 322 (51.4%) and biliary-pancreatic cancers in 114 (18.2%) of cases. No LFT (ALT, ALP and Bilirubin) predicted the diagnoses. The higher concordance rate of imaging studies in comparison with ERCP was 75% for stone(s) and the lower rate of 11.1% for tumors. Metallic stents were used in 15(2.4%) of inoperable malignant cases with life expectancy of more than 6 months. Complications occurred in 29 cases (4.6%) including duodenal perforation (0.8%), pancreatitis (1.6%) and bleeding (1.2%). Mortality rate was 0.4%. Conclusion. Although no single laboratory or imaging can exactly predict the finding or outcome, but by considering judicious case selection, appropriate use of available tools and standard techniques, the procedure could be safe with a few complications and higher success rates.
{"title":"Outcome and early complications of Endoscopic Retrograde Cholangio-Pancreatography (ERCP): a cross-sectional study on 626 Patients","authors":"Y. Bafandeh","doi":"10.34172/mj.2021.067","DOIUrl":"https://doi.org/10.34172/mj.2021.067","url":null,"abstract":"Background. ERCP is the gold standard procedure for diagnosis and potential treatment of biliary-pancreatic disorders with various distributions in different areas of the world. The study aimed to evaluate the findings, outcome, complications and technical experiences of ERCP, also by considering the correlation of findings with liver function tests (LFT) and imaging. Methods. In this descriptive – cross sectional data-based study for 12 years from 2007, 626 (43.9% male and 56.1%female; mean age 60 Ys) consecutive patients were subjected with therapeutic purpose at two referral hospitals. Results. Epigastric pain (40%), jaundice (39.4%) and pruritus (38.1%) were the most common indications. CBD was cannulated by optimal wire- guided sphincterotomy in 486(77.6%) patients. Precut was performed in 65(10.6%) with successful cannulation in 61 cases (93.8%) and 7.7% of complications, including perforation. A total success rate of 98% was obtained. The most common diagnoses were CBD stone(s) in 322 (51.4%) and biliary-pancreatic cancers in 114 (18.2%) of cases. No LFT (ALT, ALP and Bilirubin) predicted the diagnoses. The higher concordance rate of imaging studies in comparison with ERCP was 75% for stone(s) and the lower rate of 11.1% for tumors. Metallic stents were used in 15(2.4%) of inoperable malignant cases with life expectancy of more than 6 months. Complications occurred in 29 cases (4.6%) including duodenal perforation (0.8%), pancreatitis (1.6%) and bleeding (1.2%). Mortality rate was 0.4%. Conclusion. Although no single laboratory or imaging can exactly predict the finding or outcome, but by considering judicious case selection, appropriate use of available tools and standard techniques, the procedure could be safe with a few complications and higher success rates.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87314670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roya Bagheri, S. Rahmani, Leila Khoramifar, Solmaz Ilkhichoui
Background. Parental chromosomal abnormalities as well as changes in genes encoding thrombophilic factors are common causes of recurrent abortions. One of the causes of thrombophilia is Factor II (F2) gene mutation (G20210A) and plasminogen activator inhibitor gene (PAI-1) polymorphism (4G/5G). Therefore, the present study aimed to investigate the frequency of chromosomal abnormalities and the association of thrombophilic gene polymorphisms in patients with abortion in northwestern Iran. Methods. In the present case-control study, cytogenetic analysis of 60 couples with a history of recurrent abortions was performed by the standard 72-hour culture of lymphocytes and G-banding. The polymorphism (5G/4G) of PAI-1 gene and the mutation (G20210A) of F2 genes were evaluated using RFLP-PCR and ARMS-PCR molecular methods, respectively. The obtained data were analyzed using statistical software. Results. No significant abnormalities affecting abortion were observed in cytogenetic studies; in the molecular study, the frequency of the 4G allele in patients and control groups were 54.2% and 33.3%, respectively; the frequency of 5G allele in the patients and control groups were 45.8% and 66.8%, respectively. The frequency of 5G/5G and 4G/5G genotypes is 25.0% and 41.6% in the patient group, and 55.0% and 23.3% in the control group, respectively. Also, the frequency of 4G/4G genotype in patients and controls were 33.3% and 21.6%, respectively. Conclusion. The results of this study show that there is a significant relationship between the frequency of the 4G allele of the PAI-1 gene with susceptibility to recurrent abortions in northwestern women, while no was relationship between F2 gene mutation and recurrent abortions was observed.
{"title":"Study of common chromosomal abnormalities and Plasminogen activator Inhibitor(PAI-1) gene Polymorphism (5G/4G) and Prothrombin (F2)gene mutation(G20210A) in women with recurrent abortions in the North West of Iran","authors":"Roya Bagheri, S. Rahmani, Leila Khoramifar, Solmaz Ilkhichoui","doi":"10.34172/mj.2021.066","DOIUrl":"https://doi.org/10.34172/mj.2021.066","url":null,"abstract":"Background. Parental chromosomal abnormalities as well as changes in genes encoding thrombophilic factors are common causes of recurrent abortions. One of the causes of thrombophilia is Factor II (F2) gene mutation (G20210A) and plasminogen activator inhibitor gene (PAI-1) polymorphism (4G/5G). Therefore, the present study aimed to investigate the frequency of chromosomal abnormalities and the association of thrombophilic gene polymorphisms in patients with abortion in northwestern Iran. Methods. In the present case-control study, cytogenetic analysis of 60 couples with a history of recurrent abortions was performed by the standard 72-hour culture of lymphocytes and G-banding. The polymorphism (5G/4G) of PAI-1 gene and the mutation (G20210A) of F2 genes were evaluated using RFLP-PCR and ARMS-PCR molecular methods, respectively. The obtained data were analyzed using statistical software. Results. No significant abnormalities affecting abortion were observed in cytogenetic studies; in the molecular study, the frequency of the 4G allele in patients and control groups were 54.2% and 33.3%, respectively; the frequency of 5G allele in the patients and control groups were 45.8% and 66.8%, respectively. The frequency of 5G/5G and 4G/5G genotypes is 25.0% and 41.6% in the patient group, and 55.0% and 23.3% in the control group, respectively. Also, the frequency of 4G/4G genotype in patients and controls were 33.3% and 21.6%, respectively. Conclusion. The results of this study show that there is a significant relationship between the frequency of the 4G allele of the PAI-1 gene with susceptibility to recurrent abortions in northwestern women, while no was relationship between F2 gene mutation and recurrent abortions was observed.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73089645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Retrocaval ureter is a rare congenital disorder and surgery is necessary when the patient is symptomatic or having significant functional obstructions. The two cases referred to our center with severe hydronephrosis on their right sides. In both cases further evaluation with CT scan showed the diagnosis of retrocaval ureter. The retrocaval segment of the both ureters were isolated and after the excision of the narrow segments, end to end anastomosis have been done with transperitoneal laparoscopic technique. The laparoscopic ureteroureterostomy is a safe, effective and minimally invasive procedure and should be considered as a standard treatment for retrocaval ureter.
{"title":"Laparoscopic repair of retro-caval ureter: report of two cases","authors":"A. Farshi, Denial Jafarlou","doi":"10.34172/mj.2021.073","DOIUrl":"https://doi.org/10.34172/mj.2021.073","url":null,"abstract":"Retrocaval ureter is a rare congenital disorder and surgery is necessary when the patient is symptomatic or having significant functional obstructions. The two cases referred to our center with severe hydronephrosis on their right sides. In both cases further evaluation with CT scan showed the diagnosis of retrocaval ureter. The retrocaval segment of the both ureters were isolated and after the excision of the narrow segments, end to end anastomosis have been done with transperitoneal laparoscopic technique. The laparoscopic ureteroureterostomy is a safe, effective and minimally invasive procedure and should be considered as a standard treatment for retrocaval ureter.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80161413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. IGF-1 hormone decreases in patients with type 2 diabetes and NAFLD. The effect of exercise on this hormone requires further researches. The purpose of this study was to compare the effects of the interval, continuous, and combined aerobic exercise on IGF-1 hormone and body composition in type 2 diabetic patients with NAFLD. Methods. In this study, forty female type 2 diabetes patients with NAFLD (mean age 50.6 ± 4.5 years, height 1.58 ± 0.07 m, weight 74.4 ± 9.9 kg) were randomized into four groups. The exercise training groups performed exercises by cycle ergometer three days a week for eight weeks. The groups included: interval aerobic exercise group (75-80% maximum heart rate), continuous aerobic exercise group (60-75% maximum heart rate), combined exercise group (interval and continuous), and control group. Variance analysis was used for analysis and comparison between groups. The t-dependent test was used for intra-group compression (α≤0.05). Results. Decreased body weight, BMI, waist circumference, waist circumference, waist-to-height ratio, body fat percentage, body fat mass, and increased IGF-1 were significant in all three exercise groups (P≤0.05). In the control group, increased hip circumference and decreased IGF-1 were significant (P≤0.05). Among the three exercise groups, the interval aerobic exercise group had the most effect on improving type 2 diabetic patients with NAFLD. Comparing between the groups, IGF-1, body mass index, waist circumference, hip circumference, and waist-to-height ratio were significant in the interval, continuous, and combined aerobic exercise groups compared to the control group (P≥0.05). Conclusion. Interval, continuous, and combined aerobic exercise improves body composition and hormone IGF-1, and according to the findings, interval aerobic exercise had the greatest effect on diabetic patients with NAFLD. Therefore, it is recommended that these patients participate in aerobic exercise regularly, especially interval aerobic exercise.
{"title":"The effect of interval, continuous and combined aerobic exercise on IGF-1 hormone and body composition in type 2 diabetic patients with NAFLD","authors":"Z. Bayat, A. Gaeini, R. Nuri","doi":"10.34172/mj.2021.071","DOIUrl":"https://doi.org/10.34172/mj.2021.071","url":null,"abstract":"Background. IGF-1 hormone decreases in patients with type 2 diabetes and NAFLD. The effect of exercise on this hormone requires further researches. The purpose of this study was to compare the effects of the interval, continuous, and combined aerobic exercise on IGF-1 hormone and body composition in type 2 diabetic patients with NAFLD. Methods. In this study, forty female type 2 diabetes patients with NAFLD (mean age 50.6 ± 4.5 years, height 1.58 ± 0.07 m, weight 74.4 ± 9.9 kg) were randomized into four groups. The exercise training groups performed exercises by cycle ergometer three days a week for eight weeks. The groups included: interval aerobic exercise group (75-80% maximum heart rate), continuous aerobic exercise group (60-75% maximum heart rate), combined exercise group (interval and continuous), and control group. Variance analysis was used for analysis and comparison between groups. The t-dependent test was used for intra-group compression (α≤0.05). Results. Decreased body weight, BMI, waist circumference, waist circumference, waist-to-height ratio, body fat percentage, body fat mass, and increased IGF-1 were significant in all three exercise groups (P≤0.05). In the control group, increased hip circumference and decreased IGF-1 were significant (P≤0.05). Among the three exercise groups, the interval aerobic exercise group had the most effect on improving type 2 diabetic patients with NAFLD. Comparing between the groups, IGF-1, body mass index, waist circumference, hip circumference, and waist-to-height ratio were significant in the interval, continuous, and combined aerobic exercise groups compared to the control group (P≥0.05). Conclusion. Interval, continuous, and combined aerobic exercise improves body composition and hormone IGF-1, and according to the findings, interval aerobic exercise had the greatest effect on diabetic patients with NAFLD. Therefore, it is recommended that these patients participate in aerobic exercise regularly, especially interval aerobic exercise.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81649379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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