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Epidemiology and clinical findings of oral squamous cell carcinoma 口腔鳞状细胞癌的流行病学及临床表现
N. Shahidi, A. Lotfi
Background. Oral cancer is one of ten most common causes of death, because of late diagnosis due to its similarity of clinical presentation with some of the benign lesions.The aim of this research is to determine five years’ prevalence of oral squamous cell carcinoma of the patients. Methods. A descriptive cross-sectional study was done.We used SPSS software to analyze data Result. In this study, 101 patients were included, the most patients were in the seventh decade, with chief complaint was oral ulcer (61%), also only 6% of patients had a history of malignancy in their family, 22% had poor oral health status. males had a higher incidence rate than females. Conclusion. Surprisingly tobacco use was markedly low in comparison to other studies. Practical Implications. Early diagnosis of oral cavity cancers leads to proper treatment and increases survival rate of patientr.
背景。口腔癌是十大最常见的死亡原因之一,由于其临床表现与一些良性病变相似,因此诊断较晚。本研究的目的是确定口腔鳞状细胞癌患者五年内的患病率。方法。进行了描述性横断面研究。我们使用SPSS软件对数据进行分析。本研究纳入101例患者,以70岁为主,以口腔溃疡为主诉(61%),仅有6%的患者有家族恶性肿瘤病史,22%的患者口腔健康状况较差。男性的发病率高于女性。结论。令人惊讶的是,与其他研究相比,烟草使用明显较低。实际意义。口腔癌的早期诊断有助于适当的治疗,提高患者的生存率。
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引用次数: 0
The relationship between lifestyle and chronic diseases in the elderly 老年人生活方式与慢性病的关系
Mahdi Ajam, M. Sajjadi, Mohammad Reza Mansoorian, Hosein Ajamzibad
Background. Improving living conditions and increasing life expectancy have led to aging of societies. Lifestyles of the elderly and its related chronic diseases have changed by all of these factors, so this study was conducted to assess the correlation between lifestyle and chronic diseases of the elderly in Gonabad in 2019. Methods. In this descriptive-analytical study, 600 elderly residents of Gonabad were selected randomly from population covered by the three community health centers of Gonabad. Data was collected using lifestyle and its related chronic diseases questionnaires. These questionnaires were completed by interview method. The data were analyzed using independent t-test, paired t-test, ANOVA, Pearson test and chi-square test (SPSS software version 23). Results. Of the 600 participants, 321 (53.5%) were male and 279 (46.5%) were female with a mean age of 47.68 years. The lifestyle of the elderly was 0.7% favorable, 36.2% relatively favorable and 62.7% unfavorable. The prevalence of diseases in the elderly was heart disease 31.3%, blood pressure 42.8%, heart attack 8.2%, stroke 4.8%, diabetes 17.8%, cancer 6.5%, shortness of breath 17.3%, malnutrition 5.2%, constipation 16.3%, arthritis 27.3%, osteoporosis 21.3%, depression 12.8%, urinary problems 20%, vision problems 12.3%, hearing problems 12.2% and sleep problems 14%. There was a significant relationship between lifestyle and gender (P=0.001) so that the lifestyle average value of men was higher than women. There was also a negative and significant relationship between age and lifestyle (r=- 0.34) (P<0.001) so that with increasing age, lifestyle mean value decreased. Mean value of lifestyle based on educational levels was significant difference. Conclusion. Due to the high percentage of chronic diseases, low lifestyle in the elderly and relationship between lifestyle and chronic diseases of the elderly, screening and monitoring of chronic diseases should be given more attention. Also, improving the lifestyle of the elderly should be considered. Practical Implications. There is no clear and accurate information about the lifestyle of the elderly and related diseases in different parts of the country, so this study helps to better understand the lifestyle of the elderly and related chronic diseases, and by knowing them, strategies can be And designed more effective interventions to improve the lifestyle of the elderly in order to prevent and control chronic diseases threatening the elderly.
背景。生活条件的改善和预期寿命的延长导致了社会老龄化。所有这些因素都改变了老年人的生活方式及其相关慢性病,因此本研究旨在评估2019年戈纳巴德老年人生活方式与慢性病的相关性。方法。在这项描述性分析研究中,从戈纳巴德三个社区卫生中心覆盖的人口中随机选择600名老年居民。采用生活方式及其相关慢性疾病问卷收集数据。问卷采用访谈法完成。数据分析采用独立t检验、配对t检验、方差分析、Pearson检验和卡方检验(SPSS软件版本23)。结果。600名参与者中,男性321人(53.5%),女性279人(46.5%),平均年龄47.68岁。对老年人生活方式满意的占0.7%,比较满意的占36.2%,不满意的占62.7%。老年人疾病患病率为心脏病31.3%、血压42.8%、心脏病8.2%、中风4.8%、糖尿病17.8%、癌症6.5%、呼吸短短17.3%、营养不良5.2%、便秘16.3%、关节炎27.3%、骨质疏松21.3%、抑郁症12.8%、泌尿系统问题20%、视力问题12.3%、听力问题12.2%、睡眠问题14%。生活方式与性别之间存在显著相关性(P=0.001),男性生活方式平均值高于女性。年龄与生活方式呈显著负相关(r=- 0.34) (P<0.001),随着年龄的增加,生活方式平均值降低。不同受教育程度的生活方式均值差异有统计学意义。结论。由于老年人慢性病发病率高,生活方式低,生活方式与老年人慢性疾病的关系,应重视慢性病的筛查和监测。此外,还应考虑改善老年人的生活方式。实际意义。对于全国不同地区老年人的生活方式和相关疾病还没有清晰准确的信息,因此本研究有助于更好地了解老年人的生活方式和相关的慢性疾病,通过了解老年人的生活方式,可以制定策略,设计更有效的干预措施来改善老年人的生活方式,从而预防和控制威胁老年人的慢性疾病。
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引用次数: 0
Evaluating the diagnosis and intervention of a sleepwalking disorder associated with violence: A case study 评估与暴力相关的梦游障碍的诊断和干预:一个案例研究
K. Khorramdel, S. Pasalari, M. Nami
This study aimed to investigate a case of sleep problems associated with violence (non-REM parasomnias) and obstructive sleep apnea (OSA) besides related therapeutic approaches. The studied case in the present study was a 60-year-old man with a family history of this sleep disorder. The treatment plan in the present study was as follows: Execution of the principles of sleep hygiene by the patient, use of the continuous positive airway pressure machine (CPAP), and eight sessions of weekly biofeedback therapy. Before the intervention, the subject suffered from anxiety, minor depression, moderate quality of life, some degree of PTSD, obstructive sleep apnea, and periodic limb undesirable movements. After the intervention, there was a relative improvement in all indicators, especially obstructive sleep apnea and limb movements. Practical Implications. Given the prevalence and complexity of non-REM parasomnias, insufficient knowledge of the involved causes and mechanisms, and the failure of many pharmacological therapies, the present study can help discover the possible causes and alternative treatments based on physical and psychological factors.
本研究旨在探讨一例与暴力(非快速眼动睡眠异常)和阻塞性睡眠呼吸暂停(OSA)相关的睡眠问题以及相关的治疗方法。本研究的研究对象是一名60岁的男性,他有这种睡眠障碍的家族史。本研究的治疗方案为:患者执行睡眠卫生原则,使用持续气道正压机(CPAP),每周进行8次生物反馈治疗。干预前,受试者存在焦虑、轻度抑郁、中等生活质量、一定程度的PTSD、阻塞性睡眠呼吸暂停、周期性肢体不良运动。干预后,所有指标均有相对改善,尤其是阻塞性睡眠呼吸暂停和肢体运动。实际意义。鉴于非快速眼动睡眠的普遍性和复杂性,对其原因和机制的认识不足,以及许多药物治疗的失败,本研究可以帮助发现基于生理和心理因素的可能原因和替代治疗。
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引用次数: 1
The role of pain, hopelessness, belonging, and suicide capacity in predicting suicide attempt in people with psychiatric disorders 疼痛、绝望、归属感和自杀能力在预测精神障碍患者自杀企图中的作用
K. Ghaleban, Naeemeh Moheb, R. Abdi, A. Farnam
Background. The idea and attempt of suicide are highly predictive of deaths due to suicide and can lead to several negative consequences for both the individual and his family and for society. Therefore, this study was conducted with the aim of the role of pain, hopelessness, belonging and suicidal capacity in predicting suicide attempt in people with psychiatric disorders. Methods. The research method of this study was correlational and the statistical population included all individuals referred to psychiatric outpatient clinics of Razi Hospital in Tabriz in 2020-2021. Sample sizes According to Klein criterion and according to the 62-item questionnaire, 298 subjects were selected. Research tools also include the Suicide Attempt Scale, the Suicide Capacity Scale and to examine the three variables of pain, hopelessness and belonging to the Suicide Motivation Questionnaire were used. Structural equation modeling was used to analyze the data using Smart pls software version 2. Results. In this study, 63.3% of the respondents were men and 36.7% of the respondents were women. The mean and standard deviation of the age of the respondents was 37.26±10.88 years. According to the results of the path coefficients between hopelessness with suicide capacity (β= 0.63), sense of belonging with suicide capacity (β= 0.28) and suicide attempt (β= 0.21), suicide capacity with suicide attempt (β= 0.59) were at a significant level (P<0.05). On the other hand, suicidal capacity had a significant mediating role in the relationship between hopelessness and sense of belonging with suicide attempt. Conclusion. The results showed that the three-step model of suicide has the ability to predict suicide attempt in the community of patients with psychiatric disorders. Practical Implications. The results of this study are very important for professionals who work with people with psychiatric disorders to distinguish the idea of suicide from suicide attempt.
背景。自杀的想法和企图是自杀死亡的高度预测因素,并可能对个人和他的家庭以及社会造成一些负面后果。因此,本研究旨在探讨疼痛、绝望、归属感和自杀能力在预测精神障碍患者自杀企图中的作用。方法。本研究的研究方法是相关的,统计人群包括2020-2021年在大不里士Razi医院精神病门诊转诊的所有个体。根据Klein标准,根据62项问卷,选取298名被试。研究工具还包括自杀企图量表,自杀能力量表和检查三个变量的痛苦,无望和属于自杀动机问卷被使用。采用Smart pls第二版软件,采用结构方程模型对数据进行分析。结果。在这项研究中,63.3%的受访者是男性,36.7%的受访者是女性。调查对象年龄的均值和标准差为37.26±10.88岁。绝望感与自杀能力(β= 0.63)、归属感与自杀能力(β= 0.28)、自杀企图(β= 0.21)之间的路径系数结果显示,自杀能力与自杀企图(β= 0.59)之间存在显著性差异(P<0.05)。另一方面,自杀能力在绝望感、归属感与自杀企图之间具有显著的中介作用。结论。结果表明,自杀三步模型具有预测社区精神障碍患者自杀企图的能力。实际意义。这项研究的结果对于那些与精神障碍患者打交道的专业人员区分自杀和自杀企图非常重要。
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引用次数: 1
The comparison of memory and executive functions in adults with type II diabetes and healthy people 成人II型糖尿病患者与健康人的记忆和执行功能比较
A. Shafiee-Kandjani, Jalil Hoshyar-Gharamaleki, Negin Ghafari, Habibeh Barzegar
Background. The prevalence of type 2 diabetes is increasing. The disease is known to be an important risk factor for cognitive decline. Given the importance of diagnosing and controlling cognitive disorders such as memory impairment in diabetic patients and the difference of cognitive impairments in different populations, we decided to investigate the relationship between type 2 diabetes with memory and executive function . Methods. This case-control study was performed on 30 type 2 diabetic patients (case group) and 30 nondiabetic patients (control group) referred to Sheikh ol-Rayis Clinic in Tabriz during 1997. Demographic information questionnaires and Persian Cognitive Assessment Package (PCAP) were administered to all subjects in both groups. Results. pPatients with diabetes achieved lower scores in working memory tests and concentration tests compared to controls (healthy controls). There was no significant difference between the two groups regarding executive function (P<0.05). But the scores of diabetic patients in the number and symbol placement test and the number and letter placement test were significantly lower than the control group (P<0.05). Conclusion. Type 2 diabetes can have a significant impact on the concentration of these patients and impair working memory and executive function. The findings of the present study stress that patients with type 2 diabetes experience a decline in their cognitive performance. Therefore, monitoring the neuropsychological status of these group are essential. Practical Implications. Due to the effect of type 2 diabetes on the brain and the development of cognitive disorders (such as memory and executive dysfunction), if diabetes is diagnosed and treated early, cognitive impairments can be significantly prevented. Importantly, these deficiencies can affect a person's ability to perform daily activities, job performance, and self-care. It is recommended to improve the process of diabetes control to prevent cognitive disorders in patients and help improve their quality of life.
背景。2型糖尿病的患病率正在上升。众所周知,这种疾病是导致认知能力下降的一个重要风险因素。鉴于诊断和控制糖尿病患者记忆障碍等认知障碍的重要性以及不同人群认知障碍的差异,我们决定研究2型糖尿病与记忆和执行功能之间的关系。方法。本病例对照研究于1997年在大不里士的Sheikh ol-Rayis诊所对30名2型糖尿病患者(病例组)和30名非糖尿病患者(对照组)进行。对两组所有受试者进行人口统计信息问卷和波斯语认知评估包(PCAP)。结果。与对照组(健康对照组)相比,糖尿病患者在工作记忆测试和注意力测试中的得分较低。两组患者执行功能差异无统计学意义(P<0.05)。但糖尿病患者在数字符号放置测试和数字字母放置测试中的得分显著低于对照组(P<0.05)。结论。2型糖尿病会严重影响这些患者的注意力,损害他们的工作记忆和执行功能。本研究的结果强调,2型糖尿病患者的认知能力下降。因此,监测这些群体的神经心理状态是必要的。实际意义。由于2型糖尿病对大脑的影响和认知障碍的发展(如记忆和执行功能障碍),如果糖尿病得到早期诊断和治疗,可以显著预防认知障碍。重要的是,这些缺陷会影响一个人进行日常活动、工作表现和自我照顾的能力。建议改善糖尿病的控制过程,预防患者的认知障碍,帮助改善患者的生活质量。
{"title":"The comparison of memory and executive functions in adults with type II diabetes and healthy people","authors":"A. Shafiee-Kandjani, Jalil Hoshyar-Gharamaleki, Negin Ghafari, Habibeh Barzegar","doi":"10.34172/mj.2022.009","DOIUrl":"https://doi.org/10.34172/mj.2022.009","url":null,"abstract":"Background. The prevalence of type 2 diabetes is increasing. The disease is known to be an important risk factor for cognitive decline. Given the importance of diagnosing and controlling cognitive disorders such as memory impairment in diabetic patients and the difference of cognitive impairments in different populations, we decided to investigate the relationship between type 2 diabetes with memory and executive function . Methods. This case-control study was performed on 30 type 2 diabetic patients (case group) and 30 nondiabetic patients (control group) referred to Sheikh ol-Rayis Clinic in Tabriz during 1997. Demographic information questionnaires and Persian Cognitive Assessment Package (PCAP) were administered to all subjects in both groups. Results. pPatients with diabetes achieved lower scores in working memory tests and concentration tests compared to controls (healthy controls). There was no significant difference between the two groups regarding executive function (P<0.05). But the scores of diabetic patients in the number and symbol placement test and the number and letter placement test were significantly lower than the control group (P<0.05). Conclusion. Type 2 diabetes can have a significant impact on the concentration of these patients and impair working memory and executive function. The findings of the present study stress that patients with type 2 diabetes experience a decline in their cognitive performance. Therefore, monitoring the neuropsychological status of these group are essential. Practical Implications. Due to the effect of type 2 diabetes on the brain and the development of cognitive disorders (such as memory and executive dysfunction), if diabetes is diagnosed and treated early, cognitive impairments can be significantly prevented. Importantly, these deficiencies can affect a person's ability to perform daily activities, job performance, and self-care. It is recommended to improve the process of diabetes control to prevent cognitive disorders in patients and help improve their quality of life.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85542588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of combined training and activity in an enriched environment on the brain BDNF and VEGF protein levels in the pre-pubertal male rats 在丰富的环境中联合训练和活动对青春期前雄性大鼠脑BDNF和VEGF蛋白水平的影响
S. Rostami, Milad Esmailyanmaleki, Parham Kargarfard, R. Fayazmilani
Background. Neurotrophic factors play an important role in the brain plasticity. The brain developmental processes remarkably occur in the pre-pubertal period, and training interventions during this sensitive period may lead to specific effects. The purpose of this study was to investigate the effects of combined training and activity in an enriched environment on the brain BDNF and VEGF protein levels in the pre-pubertal male rats. Methods. The pre-pubertal male Wistar rats (n=18) were randomly divided into three groups of combined training (CT), enriched environment (EE), and control (C) at postnatal day 22. The combined training included endurance and resistance physical exercises, which performed six days a week. A large cage with various rich stimuli (wheel running, ladder, toys, tunnels) was provided for voluntary physical activity in an enriched environment. The interventions lasted for three weeks, and the brain tissue (right hemisphere) was removed for biochemical evaluations. The BDNF and VEGF protein levels of the brain were measured by the western blotting method. Results. Significant differences found in the BDNF and VEGF levels in this study (P<0.01). The neurotrophic factors were significantly increased in the CT and EE groups. Although VEGF protein level increased in both groups, only enriched rats showed a significant difference. Conclusion. It can be concluded that combined training and voluntary physical activity in an enriched environment in the pre-pubertal period can effective in brain plasticity by increasing the neurotrophic factors.
背景。神经营养因子在大脑可塑性中起着重要作用。大脑发育过程在青春期前显著发生,在这一敏感时期进行训练干预可能会产生特定的效果。本研究的目的是探讨在丰富的环境中进行联合训练和活动对青春期前雄性大鼠脑BDNF和VEGF蛋白水平的影响。方法。取18只青春期前雄性Wistar大鼠,于出生后22 d随机分为联合训练组(CT)、强化环境组(EE)和对照组(C)。联合训练包括耐力和抵抗力的体育锻炼,每周进行六天。一个大笼子里有各种丰富的刺激(轮子跑,梯子,玩具,隧道)提供了一个丰富的环境中自愿的身体活动。干预持续了三周,脑组织(右半球)被移除进行生化评估。western blotting法检测大鼠脑组织BDNF和VEGF蛋白水平。结果。各组BDNF、VEGF水平差异有统计学意义(P<0.01)。CT组和EE组神经营养因子明显升高。虽然两组VEGF蛋白水平均升高,但只有富集大鼠表现出显著差异。结论。综上所述,在青春期前丰富的环境中,结合训练和自愿体育活动可以通过增加神经营养因子来有效地提高大脑的可塑性。
{"title":"The effects of combined training and activity in an enriched environment on the brain BDNF and VEGF protein levels in the pre-pubertal male rats","authors":"S. Rostami, Milad Esmailyanmaleki, Parham Kargarfard, R. Fayazmilani","doi":"10.34172/mj.2022.007","DOIUrl":"https://doi.org/10.34172/mj.2022.007","url":null,"abstract":"Background. Neurotrophic factors play an important role in the brain plasticity. The brain developmental processes remarkably occur in the pre-pubertal period, and training interventions during this sensitive period may lead to specific effects. The purpose of this study was to investigate the effects of combined training and activity in an enriched environment on the brain BDNF and VEGF protein levels in the pre-pubertal male rats. Methods. The pre-pubertal male Wistar rats (n=18) were randomly divided into three groups of combined training (CT), enriched environment (EE), and control (C) at postnatal day 22. The combined training included endurance and resistance physical exercises, which performed six days a week. A large cage with various rich stimuli (wheel running, ladder, toys, tunnels) was provided for voluntary physical activity in an enriched environment. The interventions lasted for three weeks, and the brain tissue (right hemisphere) was removed for biochemical evaluations. The BDNF and VEGF protein levels of the brain were measured by the western blotting method. Results. Significant differences found in the BDNF and VEGF levels in this study (P<0.01). The neurotrophic factors were significantly increased in the CT and EE groups. Although VEGF protein level increased in both groups, only enriched rats showed a significant difference. Conclusion. It can be concluded that combined training and voluntary physical activity in an enriched environment in the pre-pubertal period can effective in brain plasticity by increasing the neurotrophic factors.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75481871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Premature cellular senescence in isolated chondrocytes from polydactyl cartilage in FBS containing serum in comparison to human serum 含血清的胎牛血清中多趾软骨分离软骨细胞的过早细胞衰老与人血清的比较
H. Shafaei, Azam Farani, Zahra Baghaei, F. Mortazavi
Background. Transplantation of chondrocytes is one of the methods for treatment of articular cartilage defects. For this purpose, it is necessary to isolate these chondrocytes and expand in serum containing culture medium. Sera contain growth factors that are added to medium. Fetal bovine serum (FBS) is used for standard cell culture. However bovine proteins of FBS are accompanied with risk of host immune system reactions. Therefore, it is necessary to replace FBS with human serum for clinical cases. In addition, infants have chondrocytes with high proliferation potency versus adults. In this study, the effects of FBS and human placental serum was investigated on morphology and cellular senescence related genes expression of chondrocytes of infants. Methods. Chondrocytes after isolation of from polydactyly cartilage tissue samples, were cultured in 10% FBS and human serum up to passage 5. Human placental serum was obtained from venous blood of embryonic surface of human placenta. Chondrocytes in two culture medium were compared morphologically by inverted microscope. For cellular senescence evaluation, relative expression of IGF1 and P16 genes were assessed by quantitative real-time RT PCR. Results. Proliferation of chondrocytes is markedly decreased in FBS groups in comparison with human serum. In FBS containing medium, phenotypes of cells were changed from spindle shape to flat appearance after five passages. The expression IGF1 and P16 genes are increased in chondrocytes grown in FBS containing medium and it was significant about P16. Morphologic results were in agreement with Real-time RT PCR results. Conclusion. Human placental serum has advantages such as high proliferation rate on human chondrocytes, prevention from cellular senescence and immunological problems in using cultured chondrocytes for cartilage tissue engineering.
背景。软骨细胞移植是治疗关节软骨缺损的方法之一。为此,有必要分离这些软骨细胞并在含培养基的血清中扩增。血清中含有添加到培养基中的生长因子。胎牛血清(FBS)用于标准细胞培养。然而,牛胎牛蛋白伴宿主免疫系统反应的危险。因此,临床病例有必要用人血清代替胎牛血清。此外,与成人相比,婴儿的软骨细胞具有较高的增殖能力。本研究研究了胎牛血清和人胎盘血清对婴儿软骨细胞形态和细胞衰老相关基因表达的影响。方法。从多指软骨组织样本中分离出软骨细胞,在10%胎牛血清和人血清中培养至5代。人胎盘血清是从人胎盘胚表面静脉血中提取的。倒置显微镜下比较两种培养基中软骨细胞的形态。采用实时荧光定量RT - PCR技术检测IGF1和P16基因的相对表达量。结果。与人血清相比,胎牛血清组软骨细胞增殖明显减少。在含FBS的培养基中,5代后细胞表型由纺锤形变为扁平状。在含FBS培养基中培养的软骨细胞中,IGF1和P16基因表达增加,其中P16表达显著增加。形态学结果与Real-time RT - PCR结果一致。结论。人胎盘血清具有对人软骨细胞增殖率高、防止细胞衰老和利用培养的软骨细胞进行软骨组织工程的免疫问题等优点。
{"title":"Premature cellular senescence in isolated chondrocytes from polydactyl cartilage in FBS containing serum in comparison to human serum","authors":"H. Shafaei, Azam Farani, Zahra Baghaei, F. Mortazavi","doi":"10.34172/mj.2022.002","DOIUrl":"https://doi.org/10.34172/mj.2022.002","url":null,"abstract":"Background. Transplantation of chondrocytes is one of the methods for treatment of articular cartilage defects. For this purpose, it is necessary to isolate these chondrocytes and expand in serum containing culture medium. Sera contain growth factors that are added to medium. Fetal bovine serum (FBS) is used for standard cell culture. However bovine proteins of FBS are accompanied with risk of host immune system reactions. Therefore, it is necessary to replace FBS with human serum for clinical cases. In addition, infants have chondrocytes with high proliferation potency versus adults. In this study, the effects of FBS and human placental serum was investigated on morphology and cellular senescence related genes expression of chondrocytes of infants. Methods. Chondrocytes after isolation of from polydactyly cartilage tissue samples, were cultured in 10% FBS and human serum up to passage 5. Human placental serum was obtained from venous blood of embryonic surface of human placenta. Chondrocytes in two culture medium were compared morphologically by inverted microscope. For cellular senescence evaluation, relative expression of IGF1 and P16 genes were assessed by quantitative real-time RT PCR. Results. Proliferation of chondrocytes is markedly decreased in FBS groups in comparison with human serum. In FBS containing medium, phenotypes of cells were changed from spindle shape to flat appearance after five passages. The expression IGF1 and P16 genes are increased in chondrocytes grown in FBS containing medium and it was significant about P16. Morphologic results were in agreement with Real-time RT PCR results. Conclusion. Human placental serum has advantages such as high proliferation rate on human chondrocytes, prevention from cellular senescence and immunological problems in using cultured chondrocytes for cartilage tissue engineering.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83902109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attitudes of infertile women referring to Tabriz Infertility Center about marital relations 到大不里士不育中心就诊的不孕妇女对婚姻关系的态度
Z. Mousavi, F. Torabi, Narges Shamsian Khoramabbadi
Background. Infertility as one of the bitter and Stressful experiences of couple’s cohabitation can affect various aspects of marital relationships, sexual relations and attitudes toward them. Therefore, the study aimed to determine attitudes of infertile women towards infertility and sexual behavior. Methods. In descriptive study with cross-sectional And retrospective study, 124 infertile women referred to the infertility center of Al-Zahra Hospital in Tabriz were selected by counting sampling method. The required data were collected through demographic information and sexual attitude questionnaire. Results. The 60 percent of participants did not report a change in the quality of their sexual relationships. Also, 63 percent of the participants state that sexual desire has no effect on infertility. Most participants did not blame anyone for their infertility (84%) and patients sexual relationships before and after awareness about infertility were not different. Conclusion. The infertility awareness had no effect on patients' sexual relationships. However, patients had problems in control of their lives and were affected by People around.
背景。不孕症作为夫妻共同生活中痛苦和紧张的经历之一,会影响夫妻关系、性关系和对他们的态度的各个方面。因此,该研究旨在确定不孕妇女对不孕和性行为的态度。方法。采用横断面和回顾性研究相结合的描述性研究方法,选取大不里士Al-Zahra医院不孕症中心的124名不孕症妇女。通过人口统计资料和性态度问卷收集所需数据。结果。60%的参与者没有报告说他们的性关系质量发生了变化。此外,63%的参与者表示,性欲对不孕症没有影响。大多数参与者(84%)没有将自己的不孕症归咎于任何人,并且患者在意识到不孕症之前和之后的性关系没有什么不同。结论。不孕意识对患者的性关系无影响。然而,患者在控制自己的生活方面存在问题,并受到周围人的影响。
{"title":"Attitudes of infertile women referring to Tabriz Infertility Center about marital relations","authors":"Z. Mousavi, F. Torabi, Narges Shamsian Khoramabbadi","doi":"10.34172/mj.2022.005","DOIUrl":"https://doi.org/10.34172/mj.2022.005","url":null,"abstract":"Background. Infertility as one of the bitter and Stressful experiences of couple’s cohabitation can affect various aspects of marital relationships, sexual relations and attitudes toward them. Therefore, the study aimed to determine attitudes of infertile women towards infertility and sexual behavior. Methods. In descriptive study with cross-sectional And retrospective study, 124 infertile women referred to the infertility center of Al-Zahra Hospital in Tabriz were selected by counting sampling method. The required data were collected through demographic information and sexual attitude questionnaire. Results. The 60 percent of participants did not report a change in the quality of their sexual relationships. Also, 63 percent of the participants state that sexual desire has no effect on infertility. Most participants did not blame anyone for their infertility (84%) and patients sexual relationships before and after awareness about infertility were not different. Conclusion. The infertility awareness had no effect on patients' sexual relationships. However, patients had problems in control of their lives and were affected by People around.","PeriodicalId":18474,"journal":{"name":"Medical journal of Tabriz University of Medical Sciences and Health Services","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73007381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of job satisfaction and hopelessness in medical assistants of Tabriz University of Medical Sciences 大不里士医科大学助理医师工作满意度与绝望感之评估
A. Mohagheghi, Seyyed Jalal Hatam Nejhad
Employee job satisfaction is one of the most important issues in any organization. Job satisfaction is described as general attitude of a person towards his job. Job satisfaction of medical assistants increases and promotes the quality of medical services and improves patients' satisfaction with medical services. The aim of this study was to determine the level of job satisfaction and hopelessness of medical assistants in educational centers of Tabriz. In this descriptive-analytical study, medical assistants of Tabriz University of Medical Sciences were selected and assessed using the Job Descriptive Index (JDI) for Job Satisfaction and Beck Hopelessness Scale. Hopelessness decreases with increasing job satisfaction (P<0.001). There was a significant relationship between hopelessness and domesticity (P=0.017) and between job satisfaction and the level of hopelessness with the marital status of assistants (P<0.001) and (P=0.043).
员工的工作满意度是任何组织中最重要的问题之一。工作满意度被描述为一个人对工作的总体态度。医务助理的工作满意度增加和促进了医疗服务质量,提高了患者对医疗服务的满意度。本研究的目的是确定大不里士市教育中心医疗助理的工作满意度和绝望程度。本研究以大不里士医科大学的医疗助理为研究对象,采用工作满意度工作描述指数(JDI)和贝克绝望量表进行评估。绝望感随工作满意度的增加而降低(P<0.001)。助理绝望与家庭生活(P=0.017)、工作满意度与绝望水平与婚姻状况(P<0.001)、婚姻状况(P=0.043)存在显著相关。
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引用次数: 0
Marriage expectation and related factors among newlywed couples in pre-marriage counseling center in Tabriz 大不里士市婚前咨询中心新婚夫妇婚姻期望及相关因素分析
Ata Khodaparast, Delara Laghousi, M. Alizadeh, Neda Gilani
Background. One of the important determinants of a successful marriage is the realistic expectation about marriage. This study aimed to assess the expectations of newly married couples about marriage referred to the pre-marital counseling center, and also the factors affecting their marriage expectations. Methods. In this cross-sectional study, to examine the level of marital expectation of newlywed couples referring to the premarital counseling center in Tabriz from August 2018 to April 2019, 284 samples were chosen. The self-administered Marriage Expectation Scale was used to collect data. Results. In a sample of 284, the mean age was 26±5 years. Approximately 52% of couples had an academic education. The mean marriage expectation score was 158.13±19.74. According to the results of logistic regression, the odds of idealistic marriage expectation among couples with an academic degree was 2.94 times higher compared to those with an under diploma degree (P= 0.003). In addition, the odds of idealistic marriage expectation among employees and self-employed couples was 3.14 and 3.16 times higher compared to the unemployed ones or housewives, respectively (P<0.05). Conclusion. The majority of couples had idealistic expectations about marriage and also couples with academic education, self-employed and employees had more idealistic marriage expectations.
背景。成功婚姻的重要决定因素之一是对婚姻的现实期望。本研究旨在评估到婚前咨询中心就诊的新婚夫妇对婚姻的期望,以及影响其婚姻期望的因素。方法。在本横断面研究中,为了检验2018年8月至2019年4月在大不里士婚前咨询中心就诊的新婚夫妇的婚姻期望水平,选取了284个样本。采用自编婚姻期望量表收集数据。结果。样本284例,平均年龄26±5岁。大约52%的夫妇接受过学术教育。平均婚姻期望得分为158.13±19.74。根据logistic回归的结果,有学历的夫妻对婚姻抱有理想主义期望的几率是没有学历的夫妻的2.94倍(P= 0.003)。此外,在职夫妇和个体户夫妇的理想主义婚姻期望的几率分别是失业夫妇和家庭主妇的3.14倍和3.16倍(P<0.05)。结论。大多数夫妇对婚姻抱有理想主义的期望,受过高等教育的夫妇、自雇人士和雇员对婚姻抱有更理想主义的期望。
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引用次数: 1
期刊
Medical journal of Tabriz University of Medical Sciences and Health Services
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