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Comparative study of stressors in medical and non-medical students of Tehran Islamic Azad University 德黑兰伊斯兰阿扎德大学医学生与非医学生压力源比较研究
Pub Date : 2021-12-01 DOI: 10.52547/iau.31.4.442
Niloufar Jeyhani, B. Akbarzadeh, N. Hasanmoradi, M. Sahebalzamani
Background: Stress is one of the perceived feelings in university students that plays an important role in students' academic performance and achievement which is often overlooked. Therefore, the present study was conducted to identify and compare stressors in medical and non-medical students. Materials and methods: In this comparative descriptive study, a sample of 380 medical and non-medical students of Islamic Azad University in Tehran, who were at the first semester of the 2019-2020 academic year were selected. The study tools included a demographic information and stressors questionnaire. Data were analyzed by SPSS-16 software using descriptive statistics and independent t-test at the significant level of 0.05. Results: There was a statistically significant difference between the medical and non-medical students of Tehran Islamic Azad University, in terms of problems related to "academic affairs", "emotions", "job, welfare and finance", "marital issues, marriage and choice of spouse", "social issues " and " family issue” (p<0.05). However, no statistically significant difference was observed between the medical and non-medical students in terms of problems related to "burnout", "unexpected events such as natural disasters”, "different accidents" and "behavioral characteristics and habits, and health issues" (p>0.05). Conclusion: The results of present study can help managers in developing educational frameworks to improve and create a suitable educational environment, recognize and improve coping strategies among students and to provide effective education for parents in order to reduce the stressors of students.
背景:压力是大学生的一种感知感受,它对学生的学习成绩和成就起着重要的作用,但往往被忽视。因此,本研究旨在识别和比较医学生和非医学生的压力源。材料与方法:在这项比较描述性研究中,选择了德黑兰伊斯兰阿扎德大学2019-2020学年第一学期的380名医科和非医科学生作为样本。研究工具包括人口统计信息和压力源问卷。采用SPSS-16软件进行数据分析,采用描述性统计和独立t检验,显著水平为0.05。结果:德黑兰伊斯兰阿扎德大学医学生与非医学生在“学术事务”、“情感”、“工作、福利和财务”、“婚姻问题、婚姻与配偶选择”、“社会问题”和“家庭问题”方面的问题差异有统计学意义(p0.05)。结论:本研究结果可以帮助管理者制定教育框架,改善和创造适宜的教育环境,识别和改善学生的应对策略,为家长提供有效的教育,以减少学生的压力源。
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引用次数: 0
Effect of high-intensity interval training and Aloe vera consumption on serum adiponectin and beta cells function in diabetic male rats 高强度间歇训练和芦荟消耗对糖尿病雄性大鼠血清脂联素和β细胞功能的影响
Pub Date : 2021-09-01 DOI: 10.52547/iau.31.3.299
Mahtab Sabzparvar, Shahin Riyahi Malayeri, B. Divkan
Background: Exercise training and the use of medicinal plants are helpful in the prevention and treatment of diabetes. The purpose of this study was to evaluate effect of eight-week high-intensity interval training and Aloe vera consumption on serum adiponectin and beta cells function in diabetic male rats. Materials and methods: In this experimental study, 32 diabetic Wistar rats with STZ (weight of 240-260 grams and an average age of 12 weeks) were randomly divided into four groups, including the “control group”, the “training group”, the “supplement group” and the “training + supplement group”. Training group was exposed to high-intensity interval training with %90 VO2max intensity for 8 weeks and 5 sessions per week for 2 to 6 minutes per session. Supplement group received 300 mg of Aloe vera daily for 8 weeks, five times a week. Data were analyzed using one-way ANOVA. Results: Eight weeks of high intensity interval training with Aloe vera supplementation resulted in a significant increase in adiponectin and insulin in diabetic male rats (P<0.05). But there was no significant difference in glucose and beta cell function (P>0.05). Conclusion: According to the findings of the present research, it seems that high intensity interval training along with Aloe vera supplementation may help to increase adiponectin and insulin and also improve diabetes control.
背景:运动训练和药用植物的使用有助于糖尿病的预防和治疗。本研究的目的是评估8周高强度间歇训练和芦荟消耗对糖尿病雄性大鼠血清脂联素和β细胞功能的影响。材料与方法:选用体重240 ~ 260 g,平均年龄12周龄的糖尿病大鼠32只,随机分为“对照组”、“训练组”、“补充组”和“训练+补充组”4组。训练组接受90%最大摄氧量的高强度间歇训练,持续8周,每周5次,每次2 - 6分钟。补充组每日给予芦荟300 mg,连续8周,每周5次。数据分析采用单因素方差分析。结果:8周的高强度间歇训练,芦荟补充剂导致糖尿病雄性大鼠脂联素和胰岛素显著增加(P0.05)。结论:根据本研究结果,高强度间歇训练与补充芦荟可能有助于增加脂联素和胰岛素,并改善糖尿病的控制。
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引用次数: 0
Evaluation of behavior of human umbilical cord-Wharton’s jelly mesenchymal stem cell on electrospun poly (lactic acid)wax nanofibers scaffold 人脐带-华氏胶间充质干细胞在电纺丝聚乳酸蜡纳米纤维支架上的性能评价
Pub Date : 2021-09-01 DOI: 10.52547/iau.31.3.266
Tina Shafaf, E. Hoveizi, S. R. Kazeminejad
Background: Mesenchymal stem cells are pluripotent stromal cells which are capable of differentiating into different cell lines. Nowadays, umbilical cord Wharton’s jelly (UC-WJ) are increasingly used as sources of stem cells. Studies show that scaffolds can affect the differentiation of stem cells to different cells and cause higher cell viability and proliferation as well. The present study aimed to evaluate the adhesion and viability of WJ-MSCs to PLA/Wax scaffold. Materials and methods: PLA/Wax scaffold was prepared using electrospinning method. Adhesion and viability of MSCs on this scaffold was investigated using scanning electron microscope (SEM) and MTT assay respectively. Results: SEM results showed that the fibers were homogeneous, uniform, and free of beads with high quality property, and adding wax to PLA significantly reduced the diameter of the nanofibers. These studies confirmed that the cells were attached to the scaffold in large numbers and with appropriate size. The results of MTT show good biocompatibility of the scaffold made with the cells and a significant increase in the survival rate of mesenchymal cells was observed during the period. Conclusion: In conclusion, using PLA/Wax scaffold has promoted the attachment, survival and proliferation of the cells and has the potential to be an important candidate for developing the efficiency of 3D-cultures in order to cure diseases.
背景:间充质干细胞是一种多能性基质细胞,能够分化成不同的细胞系。如今,脐带沃顿氏冻(UC-WJ)越来越多地被用作干细胞的来源。研究表明,支架可以影响干细胞向不同细胞的分化,提高细胞活力和增殖能力。本研究旨在评价WJ-MSCs与PLA/Wax支架的粘附性和生存能力。材料与方法:采用静电纺丝法制备PLA/Wax支架。用扫描电镜(SEM)和MTT法分别观察MSCs在支架上的粘附和活性。结果:SEM结果表明,纤维均匀、均匀、无珠,具有良好的质量性能,在PLA中加入蜡可以显著减小纳米纤维的直径。这些研究证实细胞大量且大小合适地附着在支架上。MTT实验结果表明,细胞制备的支架具有良好的生物相容性,在此期间间充质细胞存活率显著提高。结论:PLA/Wax支架具有促进细胞附着、存活和增殖的作用,有望成为提高3d培养效率、治疗疾病的重要候选材料。
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引用次数: 0
Evaluation of the prevalence of Mycobacterium tuberculosis strains isolated from tuberculosis patients referred to Pasteur Institute of Iran 伊朗巴斯德研究所肺结核患者分离结核分枝杆菌株流行率评估
Pub Date : 2021-09-01 DOI: 10.52547/iau.31.3.328
Nayereh Ebrahimzadeh, S. Irani, S. Khatami, S. Siadat
Background: Tuberculosis is a threat to public health. The epidemiology of tuberculosis can be effective in identifying the source of infection, the dominant circulating strains and achieving transmission pathways in the world. The aim of this study was to determine the genotype of Mycobacterium tuberculosis (M. tb) strains in patients referred to Pasteur Institute of Iran between 2018 and 2019. Materials and methods: In this study, 50 confirmed M. tb strains were evaluated. After M. tb strains identification and determining the drug susceptibility test, all strains were genotyped by MIRU-VNTR (Mycobacterial Interspersed Repetitive Unit Variable Number Tandem Repeat) method. Results: The most frequent genotype in all strains was CAS/Delhi (42%), followed by Haarlem (24%), NEW-1 (10%), LAM (8%), Beijing (8%), Cameroon (4%), EAI (% 2) and S (2%). Three clonal complexes and 44 singleton isolates were identified . Beijing genotype was the common genotype in MDR-TB strains. Also, QUB26 and QUB4156 loci had shown the highest of discriminative and allelic diversity. Conclusion: CAS/Delhi and Beijing genotypes were introduced as the dominant genotypes in drug sensitive and MDR strains, respectively.
背景:结核病是对公众健康的威胁。结核病流行病学可以有效地确定感染源、主要流行菌株和在世界范围内确定传播途径。本研究的目的是确定2018年至2019年在伊朗巴斯德研究所转诊的患者中结核分枝杆菌(M. tb)菌株的基因型。材料与方法:本研究对50株结核分枝杆菌进行了鉴定。经结核分枝杆菌菌株鉴定和药敏试验后,采用MIRU-VNTR (mycobacterium Interspersed Repeat Unit Variable Number Tandem Repeat)方法分型。结果:所有菌株中最常见的基因型为CAS/Delhi(42%),其次为Haarlem(24%)、NEW-1(10%)、LAM(8%)、Beijing(8%)、Cameroon(4%)、EAI(% 2)和S(2%)。鉴定出3个克隆复合体和44个单株分离株。北京基因型是耐多药结核菌株中常见的基因型。其中,QUB26和QUB4156位点的歧视多样性和等位基因多样性最高。结论:CAS/德里基因型和北京基因型分别为药敏菌株和耐多药菌株的优势基因型。
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引用次数: 0
Antibacterial effects study of nanofluid containing carbon nanotubes and evaluation of its efficacy on reducing antibiotic resistance of Pseudomonas aeruginosa 含碳纳米管纳米流体的抗菌效果研究及其对铜绿假单胞菌耐药性的降低效果评价
Pub Date : 2021-09-01 DOI: 10.52547/iau.31.3.276
Vahid Amiri, Mojgan Sheikhpour, F. Shooraj, M. Parzadeh, M. Masoumi
Background: Pseudomonas aeruginosa is an opportunistic gram-negative bacterium that causes infections of the urinary tract, respiratory tract, skin inflammation, soft tissue infections, and a variety of systemic infections. Increased antibiotic resistance in Pseudomonas aeruginosa has led to its introduction as one of the most important nosocomial infections. Recently, carbon nanotubes are important and effective antibacterial agents. Materials and methods: Carbon nanotubes were prepared as carboxyl-functionalized nanofluids and then were evaluated on Pseudomonas aeruginosa to reduce antibiotic resistance. Results: It was observed that multi-walled carbon nanotubes had antimicrobial effects on Pseudomonas aeruginosa. Bacterial resistance to the antibiotic meropenem was also significantly reduced in the presence of nanofluids containing functionalized carbon nanotubes. Thus, by co-administration of functionalized carbon nanotubes and meropenem, in the nanofluid condition, a significant reduction in growth was observed. Conclusion: In the present study, using nanofluids containing functionalized carbon nanotubes and also increasing its stability, the antibiotic resistance of Pseudomonas aeruginosa was significantly reduced in lower dilutions than antibiotics alone. However, more specialized cellular and molecular research are needed to obtain more accurate results.
背景:铜绿假单胞菌是一种机会性革兰氏阴性菌,可引起尿路感染、呼吸道感染、皮肤炎症、软组织感染和各种全身感染。铜绿假单胞菌的抗生素耐药性增加导致其作为最重要的医院感染之一引入。碳纳米管是近年来重要而有效的抗菌剂。材料与方法:制备了碳纳米管作为羧基功能化纳米流体,并对铜绿假单胞菌降低耐药性进行了评价。结果:观察到多壁碳纳米管对铜绿假单胞菌具有抗菌作用。在含有功能化碳纳米管的纳米流体中,细菌对抗生素美罗培南的耐药性也显著降低。因此,在纳米流体条件下,通过功能化碳纳米管和美罗培南的共同施用,观察到生长显著减少。结论:在本研究中,使用含有功能化碳纳米管的纳米流体并增加其稳定性,在较低稀释度下,铜绿假单胞菌的耐药性明显降低。然而,需要更专门的细胞和分子研究来获得更准确的结果。
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引用次数: 1
Preparation and evaluation of bismuth oxide nanoparticles by thermal degradation of metal organic framework 金属有机骨架热降解法制备氧化铋纳米颗粒及其性能评价
Pub Date : 2021-09-01 DOI: 10.52547/iau.31.3.259
Negar Motakef Kazemi
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引用次数: 0
The effect of Ferulic acid on motor-cognitive learning in Trimethyltin- induced hyperactivity model 阿魏酸对三甲基锡致多动症模型运动认知学习的影响
Pub Date : 2021-09-01 DOI: 10.52547/iau.31.3.307
H. Khodabandeh, M. Edalatmanesh
Background: Trimethyltin (TMT) is an organotin with selectively damage in the cerebral cortex and hippocampus which leads hyperactivity in prenatal exposure. The aim of this study was the evaluation of Ferulic acid (FER) effect on amelioration of motor and cognitive deficits in prenatal TMT-intoxication rat model. Materials and methods: In this experimental study, 30 Wistar pregnant rats were randomly divided into 5 groups, including control group, TMT+Saline group and TMT+FER25, TMT+FER50 and TMT+FER100 groups. TMT (9 mg/kg) were intraperitoneally injected to the pregnant rats on embryonic day (ED) 14. Ferulic acid groups were treated by 25, 50 and 100 mg/kg doses of Ferulic acid during ED12 to ED18. Open field test for evaluation of anxiety and locomotor activity, beam walking and grid walking test for assessment of motor learning and Y-maze for evaluation of working memory were used on postnatal day (PND) 30. The data were analyzed by ANOVA and Tukey post hoc. Results: Increased rates of anxietylike behaviors, decrease of motor learning and working memory were shown in TMT+Saline group compared to the control. Although, Ferulic acid treated groups were shown a significant amelioration in correct alteration behavior and motor learning with reduction of anxietylike behaviors (p˂0.05). Conclusion: TMT prenatal exposure impairs learning and attention in rats and Ferulic acid may reduce cognitive-behavioral deficits.
背景:三甲基锡(TMT)是一种选择性损伤大脑皮层和海马的有机锡,可导致产前暴露过度活跃。本研究的目的是评价阿魏酸(FER)对产前tmt中毒大鼠运动和认知缺陷的改善作用。材料与方法:本实验选取Wistar孕鼠30只,随机分为5组,分别为对照组、TMT+生理盐水组、TMT+FER25、TMT+FER50、TMT+FER100组。在胚胎第14天(ED)腹腔注射TMT (9 mg/kg)。在ED12至ED18期间,阿魏酸组分别给予25、50和100 mg/kg剂量的阿魏酸。在出生后第30天(PND)使用开放场测试评估焦虑和运动活动,梁行走和网格行走测试评估运动学习和y迷宫评估工作记忆。数据采用方差分析和事后分析。结果:与对照组相比,TMT+生理盐水组焦虑样行为发生率升高,运动学习和工作记忆下降。阿魏酸治疗组在正确改变行为和运动学习方面表现出显著改善,焦虑样行为减少(p小于0.05)。结论:TMT产前暴露会损害大鼠的学习和注意力,阿魏酸可能减轻认知行为缺陷。
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引用次数: 1
Preparation and invitro evaluation of extend release tablets containing carbamazepine 200mg using HPMC 4000cps 卡马西平200mg缓释片的制备及体外评价
Pub Date : 2021-09-01 DOI: 10.52547/iau.31.3.290
Zahra Saeedinia, Mohammad Reza Awadi, R. Asgharian
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引用次数: 0
Comparison of visual-spatial perception ability in patients with multiple sclerosis (MS) and normal people in Tabriz City 大不里士市多发性硬化症(MS)患者与正常人视觉空间知觉能力的比较
Pub Date : 2021-09-01 DOI: 10.52547/iau.31.3.338
Hamid Zaferani Arani, K. Alimohammadzadeh, Negin Abbasi Garravand, Zahra Abbasy
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引用次数: 0
Investigating the mediating role of attachment styles to parents and peers in predicting aggression and social self-efficacy among adolescents referred to healthcare centers in Zahedan 探讨父母和同伴依恋类型对扎黑丹医疗中心转诊青少年攻击和社会自我效能的中介作用
Pub Date : 2021-09-01 DOI: 10.52547/iau.31.3.358
M. Raghibi, H. Sheikh, Yaser Shamsollahzadeh, Morteza Jalambadani
Background: This study aimed to examine the mediating role of attachment styles to parents and peers in predicting aggression and social self-efficacy among adolescents. Materials and methods: This was a descriptive-correlational (predictive) study that regarded as an applicable study in terms of its objective. The statistical population included all adolescents referred to healthcare centers in Zahedan whom based on the latest statistics, were more than 190 adolescents. Using Morgan’s table, the sample size was determined 122 people. A convenience sampling method was applied to select the sample and the measurement tools were the Armsden and Greeberg Inventory of Parent and Peer Attachment (1987), the Buss and Perry Aggression Questionnaire (1992), and the Connolly Scale of Social Self-Efficacy (1989). Research hypotheses were analyzed using the stepwise regression analysis via SPSS ver.22. Results: Among the components of attachment to peers and parents, in the first step, feeling alienated with peers explained 11% of the variance and, in the second step, feeling alienated with parents explained 18% of the variance in aggression among the adolescents at the confidence level of 0.99. Additionally, among the components of attachment to peers, only the component of communication with peers predicted 2.5% of the variance in social self-efficacy at confidence level of 0.95. Conclusion: Attachment to parents and peers is one of the important factors contributing to aggression and social self-efficacy among adolescents.
背景:本研究旨在探讨父母和同伴依恋类型对青少年攻击行为和社会自我效能感的中介作用。材料和方法:这是一项描述性相关(预测性)研究,就其目的而言,被认为是一项适用的研究。统计人口包括转诊到扎黑丹保健中心的所有青少年,根据最新统计,他们有190多名青少年。根据摩根的表格,样本量确定为122人。本研究采用便利抽样法选取样本,测量工具为Armsden and greenberg父母与同伴依恋量表(1987)、Buss and Perry攻击问卷(1992)和Connolly社会自我效能量表(1989)。采用SPSS ver.22软件对研究假设进行逐步回归分析。结果:在同伴依恋和父母依恋成分中,在第一步中,与同伴疏远感解释了11%的方差;在第二步中,与父母疏远感解释了18%的攻击性方差,置信水平为0.99。此外,在同伴依恋的组成部分中,只有同伴沟通的组成部分在0.95的置信水平上预测了2.5%的社会自我效能方差。结论:父母依恋和同伴依恋是影响青少年攻击行为和社会自我效能感的重要因素之一。
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引用次数: 0
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