Amanda S Nitschke,Paramdeep Kaur,Naomi Phagau,Helena Abreu do Valle,Jeffrey N Bone,Brenda Poon,Martin Guhn,Simone N Vigod,Tim F Oberlander,Gillian E Hanley
BACKGROUNDTo examine, using repeated measures, whether prenatal serotonin/norepinephrine reuptake inhibitor (SRI) antidepressant exposure is associated with increased anxious behaviors at kindergarten age and anxiety and/or depression behaviors after kindergarten and into adolescence.METHODSThis population-based retrospective cohort study included all live singleton infants delivered in British Columbia, Canada between January 2001 and December 2012 with complete outcome data. Follow-up lasted until December 2022. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR). To minimize confounding, high-dimensional propensity score adjustment and a matched discordant sibling-pair analysis were conducted.RESULTSPrenatal SRI exposure was associated with increased anxious behaviors in kindergarten (OR 1.77 [95% CI 1.59-1.97]) and anxiety and/or depression diagnostic codes in later childhood or adolescence (OR 2.09 [95% CI 1.97-2.22]). These associations attenuated but remained positive after high-dimensional propensity score adjustment; however, the associations did not remain in the conditional logistic regression of discordant sibling pairs (aORs 0.92 [95% CI 0.61-1.37] and 1.02 [95% CI 0.79-1.33]). Regardless of SRI exposure, children with high levels of anxious behaviors at kindergarten were more likely to receive anxiety and/or depression diagnostic codes later on (SRI exposed: aOR 1.59 [95% CI 1.24-2.06]; SRI unexposed: aOR 1.64 [95% CI 1.51-1.77]).CONCLUSIONSThe associations of prenatal SRI exposure with increased internalizing behaviors at kindergarten and into adolescence are likely due to shared genetics or environmental factors. Findings also suggested kindergarten as a time for targeted interventions to address developmental vulnerabilities and prevent later development of anxiety and/or depression.
背景:通过重复测量,研究产前血清素/去甲肾上腺素再摄取抑制剂(SRI)抗抑郁药物暴露是否与幼儿园年龄焦虑行为的增加以及幼儿园后和青春期焦虑和/或抑郁行为的增加有关。方法本研究基于人群的回顾性队列研究纳入了2001年1月至2012年12月在加拿大不列颠哥伦比亚省出生的所有活单胎婴儿,并提供了完整的结局数据。随访持续到2022年12月。Logistic回归模型用于估计未调整和调整的比值比(OR)。为了尽量减少混淆,进行了高维倾向得分调整和匹配不一致的兄弟姐妹对分析。结果产前SRI暴露与幼儿园焦虑行为增加(OR 1.77 [95% CI 1.59-1.97])和儿童后期或青春期焦虑和/或抑郁诊断代码增加(OR 2.09 [95% CI 1.97-2.22])相关。在高维倾向得分调整后,这些关联减弱,但仍保持正相关;然而,在条件逻辑回归中,不一致的兄弟姐妹之间的关联并不存在(aor分别为0.92 [95% CI 0.61-1.37]和1.02 [95% CI 0.79-1.33])。不管是否暴露于SRI,在幼儿园有高水平焦虑行为的儿童更有可能在以后接受焦虑和/或抑郁诊断代码(SRI暴露:aOR 1.59 [95% CI 1.24-2.06]; SRI未暴露:aOR 1.64 [95% CI 1.51-1.77])。结论产前SRI暴露与幼儿园和青春期内化行为增加的关联可能是由于共同的遗传或环境因素。研究结果还表明,幼儿园是一个有针对性的干预时间,以解决发展脆弱性,防止后来发展为焦虑和/或抑郁。
{"title":"Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence.","authors":"Amanda S Nitschke,Paramdeep Kaur,Naomi Phagau,Helena Abreu do Valle,Jeffrey N Bone,Brenda Poon,Martin Guhn,Simone N Vigod,Tim F Oberlander,Gillian E Hanley","doi":"10.1111/jcpp.70056","DOIUrl":"https://doi.org/10.1111/jcpp.70056","url":null,"abstract":"BACKGROUNDTo examine, using repeated measures, whether prenatal serotonin/norepinephrine reuptake inhibitor (SRI) antidepressant exposure is associated with increased anxious behaviors at kindergarten age and anxiety and/or depression behaviors after kindergarten and into adolescence.METHODSThis population-based retrospective cohort study included all live singleton infants delivered in British Columbia, Canada between January 2001 and December 2012 with complete outcome data. Follow-up lasted until December 2022. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR). To minimize confounding, high-dimensional propensity score adjustment and a matched discordant sibling-pair analysis were conducted.RESULTSPrenatal SRI exposure was associated with increased anxious behaviors in kindergarten (OR 1.77 [95% CI 1.59-1.97]) and anxiety and/or depression diagnostic codes in later childhood or adolescence (OR 2.09 [95% CI 1.97-2.22]). These associations attenuated but remained positive after high-dimensional propensity score adjustment; however, the associations did not remain in the conditional logistic regression of discordant sibling pairs (aORs 0.92 [95% CI 0.61-1.37] and 1.02 [95% CI 0.79-1.33]). Regardless of SRI exposure, children with high levels of anxious behaviors at kindergarten were more likely to receive anxiety and/or depression diagnostic codes later on (SRI exposed: aOR 1.59 [95% CI 1.24-2.06]; SRI unexposed: aOR 1.64 [95% CI 1.51-1.77]).CONCLUSIONSThe associations of prenatal SRI exposure with increased internalizing behaviors at kindergarten and into adolescence are likely due to shared genetics or environmental factors. Findings also suggested kindergarten as a time for targeted interventions to address developmental vulnerabilities and prevent later development of anxiety and/or depression.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"85 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Johanna Keller,William Polmear Locke Mandy,Moritz Herle,Virginia Carter Leno
BACKGROUNDAutistic individuals and individuals with ADHD are more likely to experience eating disorders, yet the reasons for this are not well understood. We investigated whether childhood neurodivergent (i.e. autistic and ADHD) traits are associated with patterns of emotional/restrained eating and externally driven eating behaviours in adolescence, whether these associations differed by sex and if they are mediated by anxiety.METHODSWe tested the association between parent-reported childhood (age 7 years) autistic and ADHD (i.e. hyperactivity/impulsivity, inattention) traits and self-reported adolescent (age 13) eating behaviours in a large population-representative prospective cohort (N = 7,572; Avon Longitudinal Study of Parents and Children). We performed multi-group longitudinal analysis stratified by sex to understand whether sex moderates' associations between neurodevelopmental traits and adolescent eating behaviours. Mediation models tested the extent to which observed associations were driven by mid-childhood (age 10) anxiety symptoms. All analyses were adjusted for child sex, child ethnicity, maternal education levels and maternal age at birth.RESULTSIndividuals who had higher childhood autistic traits were more likely to report emotional/restrained (b = 0.59, 95% CI [0.29, 0.88], p < .001, B = 0.07) and externally driven (b = 0.17, 95% CI [0.05, 0.28], p < .01, B = 0.06) eating behaviours during adolescence. Additionally, individuals with higher childhood inattention traits were more likely to report externally driven eating behaviours (b = 0.10, 95% CI [0.03, 0.19], p = .02, B = 0.05). No sex differences were identified in the associations. Mediation models suggested a significant indirect effect of anxiety for the association between autistic traits and emotional/restrained eating (b = 0.08, bootstrapped 95% CIs [0.02, 0.13]).CONCLUSIONSAutistic and ADHD traits in childhood may share some eating behaviour phenotypes in adolescence (externally driven eating), whereas others are specific to autism (emotional/restrained eating). We present evidence for the role of anxiety in underpinning the association between autistic traits and emotional/restrained eating behaviours, suggesting an important potential intervention target.
自闭症患者和多动症患者更容易出现饮食失调,但其原因尚不清楚。我们调查了儿童时期的神经发散性(即自闭症和多动症)特征是否与青春期的情绪/克制性饮食和外部驱动性饮食行为模式有关,这些联系是否因性别而异,以及它们是否由焦虑介导。方法我们在一个具有较大人口代表性的前瞻性队列中(N = 7,572;雅芳父母与儿童纵向研究)测试了父母报告的儿童(7岁)自闭症和多动症(即多动/冲动,注意力不集中)特征与青少年(13岁)饮食行为之间的关系。我们进行了按性别分层的多组纵向分析,以了解性别是否调节神经发育特征和青少年饮食行为之间的关联。中介模型测试了观察到的关联在多大程度上受儿童中期(10岁)焦虑症状的驱动。所有分析都根据儿童性别、儿童种族、母亲教育水平和母亲出生年龄进行了调整。结果具有较高儿童自闭症特征的个体更容易报告情绪/克制(b = 0.59, 95% CI [0.29, 0.88], p <。001年,B = 0.07)和外部驱动(B = 0.17, 95%可信区间[0.05,0.28],p <。01, B = 0.06)青少年的饮食行为。此外,具有较高儿童注意力不集中特征的个体更有可能报告外部驱动的饮食行为(b = 0.10, 95% CI [0.03, 0.19], p =。02, b = 0.05)。在这些关联中没有发现性别差异。中介模型表明,焦虑对自闭症特征与情绪性/克制性饮食之间的关联具有显著的间接影响(b = 0.08, 95% ci自举[0.02,0.13])。结论儿童时期的自闭症和ADHD特征可能在青春期有一些共同的饮食行为表型(外部驱动进食),而其他特征则是自闭症特有的(情绪性/克制性进食)。我们提供的证据表明,焦虑在自闭症特征和情绪/克制饮食行为之间的关联中起着重要的作用,这表明了一个重要的潜在干预目标。
{"title":"Adolescent eating behaviours: associations with autistic and ADHD traits in childhood and the mediating role of anxiety.","authors":"Johanna Keller,William Polmear Locke Mandy,Moritz Herle,Virginia Carter Leno","doi":"10.1111/jcpp.70051","DOIUrl":"https://doi.org/10.1111/jcpp.70051","url":null,"abstract":"BACKGROUNDAutistic individuals and individuals with ADHD are more likely to experience eating disorders, yet the reasons for this are not well understood. We investigated whether childhood neurodivergent (i.e. autistic and ADHD) traits are associated with patterns of emotional/restrained eating and externally driven eating behaviours in adolescence, whether these associations differed by sex and if they are mediated by anxiety.METHODSWe tested the association between parent-reported childhood (age 7 years) autistic and ADHD (i.e. hyperactivity/impulsivity, inattention) traits and self-reported adolescent (age 13) eating behaviours in a large population-representative prospective cohort (N = 7,572; Avon Longitudinal Study of Parents and Children). We performed multi-group longitudinal analysis stratified by sex to understand whether sex moderates' associations between neurodevelopmental traits and adolescent eating behaviours. Mediation models tested the extent to which observed associations were driven by mid-childhood (age 10) anxiety symptoms. All analyses were adjusted for child sex, child ethnicity, maternal education levels and maternal age at birth.RESULTSIndividuals who had higher childhood autistic traits were more likely to report emotional/restrained (b = 0.59, 95% CI [0.29, 0.88], p < .001, B = 0.07) and externally driven (b = 0.17, 95% CI [0.05, 0.28], p < .01, B = 0.06) eating behaviours during adolescence. Additionally, individuals with higher childhood inattention traits were more likely to report externally driven eating behaviours (b = 0.10, 95% CI [0.03, 0.19], p = .02, B = 0.05). No sex differences were identified in the associations. Mediation models suggested a significant indirect effect of anxiety for the association between autistic traits and emotional/restrained eating (b = 0.08, bootstrapped 95% CIs [0.02, 0.13]).CONCLUSIONSAutistic and ADHD traits in childhood may share some eating behaviour phenotypes in adolescence (externally driven eating), whereas others are specific to autism (emotional/restrained eating). We present evidence for the role of anxiety in underpinning the association between autistic traits and emotional/restrained eating behaviours, suggesting an important potential intervention target.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"11 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amy Shakeshaft,Luis C Farhat,Charlotte A Dennison,Olga Eyre,Olakunle Oginni,Michael C O'Donovan,Argyris Stringaris,Ellen Leibenluft,Guilherme V Polanczyk,Lucy Riglin,Anita Thapar
BACKGROUNDIrritability is a common reason for referral to child and adolescent mental health services. However, debate exists as to whether irritability is best conceptualised and treated as a feature of mood disorder, oppositional defiant disorder or a core symptom of ADHD.METHODSWe use network analyses to examine the relationships between adolescent irritability, headstrong/hurtful ODD items, depression and ADHD phenotypes, and polygenic scores (PGS) for depression and ADHD using the Avon Longitudinal Study of Parents and Children (ALSPAC). In primary analysis, irritability, depression, headstrong/hurtful ODD items and ADHD were defined using the Development and Well-Being Assessment (DAWBA) at age 15. In secondary analysis, phenotypes were defined using the Short Mood and Feelings Questionnaire (SMFQ) and the Strengths and Difficulties Questionnaire (SDQ) ADHD and behavioural subscales at age 13. Finally, we tested for network replicability using confirmatory network analysis in the Millennium Cohort Study (MCS).RESULTSResults of network analyses using the DAWBA in ALSPAC indicated irritability was most strongly associated with headstrong/hurtful ODD items, followed by ADHD and depression. When including PGS, we observed an edge between irritability and depression PGS but not between irritability and ADHD PGS. Irritability appeared to be the primary pathway between ADHD and depression as well as between headstrong/hurtful ODD items and depression. Results were similar using SMFQ/SDQ in ALSPAC and confirmatory network analysis indicated excellent model fit in MCS.CONCLUSIONSAlthough irritability appears to be transdiagnostic, phenotypically, it was most strongly associated with headstrong/hurtful ODD items and broader behavioural problems, which favours the ICD-11 approach of including irritability as a specifier of ODD. However, irritability appeared to be a key connector between both ADHD and behavioural problems to depression; thus, is important to monitor and treat in affected youth with ADHD or behavioural problems.
{"title":"Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis.","authors":"Amy Shakeshaft,Luis C Farhat,Charlotte A Dennison,Olga Eyre,Olakunle Oginni,Michael C O'Donovan,Argyris Stringaris,Ellen Leibenluft,Guilherme V Polanczyk,Lucy Riglin,Anita Thapar","doi":"10.1111/jcpp.70040","DOIUrl":"https://doi.org/10.1111/jcpp.70040","url":null,"abstract":"BACKGROUNDIrritability is a common reason for referral to child and adolescent mental health services. However, debate exists as to whether irritability is best conceptualised and treated as a feature of mood disorder, oppositional defiant disorder or a core symptom of ADHD.METHODSWe use network analyses to examine the relationships between adolescent irritability, headstrong/hurtful ODD items, depression and ADHD phenotypes, and polygenic scores (PGS) for depression and ADHD using the Avon Longitudinal Study of Parents and Children (ALSPAC). In primary analysis, irritability, depression, headstrong/hurtful ODD items and ADHD were defined using the Development and Well-Being Assessment (DAWBA) at age 15. In secondary analysis, phenotypes were defined using the Short Mood and Feelings Questionnaire (SMFQ) and the Strengths and Difficulties Questionnaire (SDQ) ADHD and behavioural subscales at age 13. Finally, we tested for network replicability using confirmatory network analysis in the Millennium Cohort Study (MCS).RESULTSResults of network analyses using the DAWBA in ALSPAC indicated irritability was most strongly associated with headstrong/hurtful ODD items, followed by ADHD and depression. When including PGS, we observed an edge between irritability and depression PGS but not between irritability and ADHD PGS. Irritability appeared to be the primary pathway between ADHD and depression as well as between headstrong/hurtful ODD items and depression. Results were similar using SMFQ/SDQ in ALSPAC and confirmatory network analysis indicated excellent model fit in MCS.CONCLUSIONSAlthough irritability appears to be transdiagnostic, phenotypically, it was most strongly associated with headstrong/hurtful ODD items and broader behavioural problems, which favours the ICD-11 approach of including irritability as a specifier of ODD. However, irritability appeared to be a key connector between both ADHD and behavioural problems to depression; thus, is important to monitor and treat in affected youth with ADHD or behavioural problems.","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"20 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patty Leijten, G.J. Melendez-Torres, Sophia Backhaus, Frances Gardner, Annabeth P. Groenman, Tycho J. Dekkers, Barbara J. van den Hoofdakker, Liina Björg Laas Sigurðardóttir, Danni Liu, Marjolein Luman, Lara Mansur, Merlin Nieterau, Saskia van der Oord, Geertjan Overbeek, Constantina Psyllou, Karen Rienks, Susanne Schulz, John R. Weisz