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Association of prenatal antidepressant use with internalizing behaviors from kindergarten to adolescence. 产前抗抑郁药使用与从幼儿园到青春期的内化行为的关系。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-25 DOI: 10.1111/jcpp.70056
Amanda S Nitschke,Paramdeep Kaur,Naomi Phagau,Helena Abreu do Valle,Jeffrey N Bone,Brenda Poon,Martin Guhn,Simone N Vigod,Tim F Oberlander,Gillian E Hanley
BACKGROUNDTo examine, using repeated measures, whether prenatal serotonin/norepinephrine reuptake inhibitor (SRI) antidepressant exposure is associated with increased anxious behaviors at kindergarten age and anxiety and/or depression behaviors after kindergarten and into adolescence.METHODSThis population-based retrospective cohort study included all live singleton infants delivered in British Columbia, Canada between January 2001 and December 2012 with complete outcome data. Follow-up lasted until December 2022. Logistic regression models were used to estimate unadjusted and adjusted odds ratios (OR). To minimize confounding, high-dimensional propensity score adjustment and a matched discordant sibling-pair analysis were conducted.RESULTSPrenatal SRI exposure was associated with increased anxious behaviors in kindergarten (OR 1.77 [95% CI 1.59-1.97]) and anxiety and/or depression diagnostic codes in later childhood or adolescence (OR 2.09 [95% CI 1.97-2.22]). These associations attenuated but remained positive after high-dimensional propensity score adjustment; however, the associations did not remain in the conditional logistic regression of discordant sibling pairs (aORs 0.92 [95% CI 0.61-1.37] and 1.02 [95% CI 0.79-1.33]). Regardless of SRI exposure, children with high levels of anxious behaviors at kindergarten were more likely to receive anxiety and/or depression diagnostic codes later on (SRI exposed: aOR 1.59 [95% CI 1.24-2.06]; SRI unexposed: aOR 1.64 [95% CI 1.51-1.77]).CONCLUSIONSThe associations of prenatal SRI exposure with increased internalizing behaviors at kindergarten and into adolescence are likely due to shared genetics or environmental factors. Findings also suggested kindergarten as a time for targeted interventions to address developmental vulnerabilities and prevent later development of anxiety and/or depression.
背景:通过重复测量,研究产前血清素/去甲肾上腺素再摄取抑制剂(SRI)抗抑郁药物暴露是否与幼儿园年龄焦虑行为的增加以及幼儿园后和青春期焦虑和/或抑郁行为的增加有关。方法本研究基于人群的回顾性队列研究纳入了2001年1月至2012年12月在加拿大不列颠哥伦比亚省出生的所有活单胎婴儿,并提供了完整的结局数据。随访持续到2022年12月。Logistic回归模型用于估计未调整和调整的比值比(OR)。为了尽量减少混淆,进行了高维倾向得分调整和匹配不一致的兄弟姐妹对分析。结果产前SRI暴露与幼儿园焦虑行为增加(OR 1.77 [95% CI 1.59-1.97])和儿童后期或青春期焦虑和/或抑郁诊断代码增加(OR 2.09 [95% CI 1.97-2.22])相关。在高维倾向得分调整后,这些关联减弱,但仍保持正相关;然而,在条件逻辑回归中,不一致的兄弟姐妹之间的关联并不存在(aor分别为0.92 [95% CI 0.61-1.37]和1.02 [95% CI 0.79-1.33])。不管是否暴露于SRI,在幼儿园有高水平焦虑行为的儿童更有可能在以后接受焦虑和/或抑郁诊断代码(SRI暴露:aOR 1.59 [95% CI 1.24-2.06]; SRI未暴露:aOR 1.64 [95% CI 1.51-1.77])。结论产前SRI暴露与幼儿园和青春期内化行为增加的关联可能是由于共同的遗传或环境因素。研究结果还表明,幼儿园是一个有针对性的干预时间,以解决发展脆弱性,防止后来发展为焦虑和/或抑郁。
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引用次数: 0
Adolescent eating behaviours: associations with autistic and ADHD traits in childhood and the mediating role of anxiety. 青少年饮食行为:与儿童时期自闭症和多动症特征的关联以及焦虑的中介作用。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-22 DOI: 10.1111/jcpp.70051
Johanna Keller,William Polmear Locke Mandy,Moritz Herle,Virginia Carter Leno
BACKGROUNDAutistic individuals and individuals with ADHD are more likely to experience eating disorders, yet the reasons for this are not well understood. We investigated whether childhood neurodivergent (i.e. autistic and ADHD) traits are associated with patterns of emotional/restrained eating and externally driven eating behaviours in adolescence, whether these associations differed by sex and if they are mediated by anxiety.METHODSWe tested the association between parent-reported childhood (age 7 years) autistic and ADHD (i.e. hyperactivity/impulsivity, inattention) traits and self-reported adolescent (age 13) eating behaviours in a large population-representative prospective cohort (N = 7,572; Avon Longitudinal Study of Parents and Children). We performed multi-group longitudinal analysis stratified by sex to understand whether sex moderates' associations between neurodevelopmental traits and adolescent eating behaviours. Mediation models tested the extent to which observed associations were driven by mid-childhood (age 10) anxiety symptoms. All analyses were adjusted for child sex, child ethnicity, maternal education levels and maternal age at birth.RESULTSIndividuals who had higher childhood autistic traits were more likely to report emotional/restrained (b = 0.59, 95% CI [0.29, 0.88], p < .001, B = 0.07) and externally driven (b = 0.17, 95% CI [0.05, 0.28], p < .01, B = 0.06) eating behaviours during adolescence. Additionally, individuals with higher childhood inattention traits were more likely to report externally driven eating behaviours (b = 0.10, 95% CI [0.03, 0.19], p = .02, B = 0.05). No sex differences were identified in the associations. Mediation models suggested a significant indirect effect of anxiety for the association between autistic traits and emotional/restrained eating (b = 0.08, bootstrapped 95% CIs [0.02, 0.13]).CONCLUSIONSAutistic and ADHD traits in childhood may share some eating behaviour phenotypes in adolescence (externally driven eating), whereas others are specific to autism (emotional/restrained eating). We present evidence for the role of anxiety in underpinning the association between autistic traits and emotional/restrained eating behaviours, suggesting an important potential intervention target.
自闭症患者和多动症患者更容易出现饮食失调,但其原因尚不清楚。我们调查了儿童时期的神经发散性(即自闭症和多动症)特征是否与青春期的情绪/克制性饮食和外部驱动性饮食行为模式有关,这些联系是否因性别而异,以及它们是否由焦虑介导。方法我们在一个具有较大人口代表性的前瞻性队列中(N = 7,572;雅芳父母与儿童纵向研究)测试了父母报告的儿童(7岁)自闭症和多动症(即多动/冲动,注意力不集中)特征与青少年(13岁)饮食行为之间的关系。我们进行了按性别分层的多组纵向分析,以了解性别是否调节神经发育特征和青少年饮食行为之间的关联。中介模型测试了观察到的关联在多大程度上受儿童中期(10岁)焦虑症状的驱动。所有分析都根据儿童性别、儿童种族、母亲教育水平和母亲出生年龄进行了调整。结果具有较高儿童自闭症特征的个体更容易报告情绪/克制(b = 0.59, 95% CI [0.29, 0.88], p <。001年,B = 0.07)和外部驱动(B = 0.17, 95%可信区间[0.05,0.28],p <。01, B = 0.06)青少年的饮食行为。此外,具有较高儿童注意力不集中特征的个体更有可能报告外部驱动的饮食行为(b = 0.10, 95% CI [0.03, 0.19], p =。02, b = 0.05)。在这些关联中没有发现性别差异。中介模型表明,焦虑对自闭症特征与情绪性/克制性饮食之间的关联具有显著的间接影响(b = 0.08, 95% ci自举[0.02,0.13])。结论儿童时期的自闭症和ADHD特征可能在青春期有一些共同的饮食行为表型(外部驱动进食),而其他特征则是自闭症特有的(情绪性/克制性进食)。我们提供的证据表明,焦虑在自闭症特征和情绪/克制饮食行为之间的关联中起着重要的作用,这表明了一个重要的潜在干预目标。
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引用次数: 0
Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis. 利用网络分析绘制青少年易怒、抑郁和ADHD之间的表型和遗传关系。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-20 DOI: 10.1111/jcpp.70040
Amy Shakeshaft,Luis C Farhat,Charlotte A Dennison,Olga Eyre,Olakunle Oginni,Michael C O'Donovan,Argyris Stringaris,Ellen Leibenluft,Guilherme V Polanczyk,Lucy Riglin,Anita Thapar
BACKGROUNDIrritability is a common reason for referral to child and adolescent mental health services. However, debate exists as to whether irritability is best conceptualised and treated as a feature of mood disorder, oppositional defiant disorder or a core symptom of ADHD.METHODSWe use network analyses to examine the relationships between adolescent irritability, headstrong/hurtful ODD items, depression and ADHD phenotypes, and polygenic scores (PGS) for depression and ADHD using the Avon Longitudinal Study of Parents and Children (ALSPAC). In primary analysis, irritability, depression, headstrong/hurtful ODD items and ADHD were defined using the Development and Well-Being Assessment (DAWBA) at age 15. In secondary analysis, phenotypes were defined using the Short Mood and Feelings Questionnaire (SMFQ) and the Strengths and Difficulties Questionnaire (SDQ) ADHD and behavioural subscales at age 13. Finally, we tested for network replicability using confirmatory network analysis in the Millennium Cohort Study (MCS).RESULTSResults of network analyses using the DAWBA in ALSPAC indicated irritability was most strongly associated with headstrong/hurtful ODD items, followed by ADHD and depression. When including PGS, we observed an edge between irritability and depression PGS but not between irritability and ADHD PGS. Irritability appeared to be the primary pathway between ADHD and depression as well as between headstrong/hurtful ODD items and depression. Results were similar using SMFQ/SDQ in ALSPAC and confirmatory network analysis indicated excellent model fit in MCS.CONCLUSIONSAlthough irritability appears to be transdiagnostic, phenotypically, it was most strongly associated with headstrong/hurtful ODD items and broader behavioural problems, which favours the ICD-11 approach of including irritability as a specifier of ODD. However, irritability appeared to be a key connector between both ADHD and behavioural problems to depression; thus, is important to monitor and treat in affected youth with ADHD or behavioural problems.
背景:可逆性是儿童和青少年心理健康服务转诊的常见原因。然而,关于易怒是最好的概念化和治疗作为情绪障碍的特征,对立违抗性障碍或ADHD的核心症状存在争议。方法采用网络分析方法,利用雅芳父母与儿童纵向研究(ALSPAC),研究青少年易怒、任性/伤害性ODD项目、抑郁和ADHD表型以及抑郁和ADHD多基因评分(PGS)之间的关系。在初步分析中,易怒、抑郁、任性/伤害性ODD项目和ADHD在15岁时使用发展和幸福评估(DAWBA)进行定义。在二级分析中,使用13岁时的短期情绪和感觉问卷(SMFQ)和优势和困难问卷(SDQ) ADHD和行为量表来定义表型。最后,我们在千年队列研究(MCS)中使用验证性网络分析测试了网络的可复制性。结果在ALSPAC中使用DAWBA的网络分析结果表明,易怒与任性/伤害性ODD项目的相关性最强,其次是ADHD和抑郁。当包括PGS时,我们观察到易怒和抑郁PGS之间存在优势,但易怒和ADHD PGS之间没有优势。易怒似乎是ADHD和抑郁之间的主要途径,也是任性/伤害性ODD和抑郁之间的主要途径。在ALSPAC中使用SMFQ/SDQ结果相似,验证性网络分析表明MCS模型拟合良好。结论虽然易怒似乎是跨诊断的,但在表型上,它与任性/伤害性ODD项目和更广泛的行为问题密切相关,这有利于ICD-11将易怒作为ODD的一个具体指标。然而,易怒似乎是ADHD和行为问题与抑郁症之间的关键联系;因此,监测和治疗患有多动症或行为问题的青少年是很重要的。
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引用次数: 0
Have parenting programs for disruptive child behavior become less effective? 针对破坏性儿童行为的育儿计划变得不那么有效了吗?
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-18 DOI: 10.1111/jcpp.70049
Patty Leijten, G.J. Melendez-Torres, Sophia Backhaus, Frances Gardner, Annabeth P. Groenman, Tycho J. Dekkers, Barbara J. van den Hoofdakker, Liina Björg Laas Sigurðardóttir, Danni Liu, Marjolein Luman, Lara Mansur, Merlin Nieterau, Saskia van der Oord, Geertjan Overbeek, Constantina Psyllou, Karen Rienks, Susanne Schulz, John R. Weisz

Background

Behavioral parenting programs have been exhaustively studied over the past five decades. We used this wealth of research to examine how estimates of parenting program effects have evolved over time, and if any time trends in effect estimates can be explained by trial, sample, or intervention characteristics.

Methods

We based our meta-analysis on a systematic search of 22 international and regional databases, gray literature, and 4 trial registries for randomized controlled trials of behavioral parenting programs.

Results

We identified 244 eligible trials (1,100 effect sizes; 28,916 families) from 36 countries. Parenting program effects initially reduced and then stabilized. More recent trials used more rigorous methods (e.g., more active control conditions and less risk of bias), samples that were generally older and included more girls, and evaluated interventions that on average had fewer sessions, were more often delivered by independent staff and made less use of time-out. However, none of these developments explained the initial reduction in effect size estimates during the first decades.

Conclusions

Our findings suggest that estimates of parenting program effects are currently stable: Effect sizes are no longer reducing but there is also no evidence of increases over time. Experimentation with the content, delivery, and personalization of parenting programs is needed to identify ways to increase program effects.

在过去的50年里,人们对行为育儿项目进行了详尽的研究。我们利用这些丰富的研究来检验对育儿计划效果的估计是如何随着时间的推移而演变的,以及是否有任何时间趋势可以用试验、样本或干预特征来解释。方法:我们基于对22个国际和地区数据库、灰色文献和4个行为育儿项目随机对照试验的试验注册库的系统检索进行meta分析。我们确定了来自36个国家的244项符合条件的试验(1100个效应量;28,916个家庭)。育儿计划的效果最初减弱,然后趋于稳定。最近的试验采用了更严格的方法(例如,更积极的控制条件和更少的偏差风险),样本通常年龄较大,包括更多的女孩,评估的干预措施平均疗程更少,更经常由独立工作人员提供,使用暂停时间更少。然而,这些发展都不能解释最初几十年效应量估计值的减少。我们的研究结果表明,对育儿计划影响的估计目前是稳定的:影响大小不再减少,但也没有证据表明随着时间的推移会增加。需要对育儿项目的内容、方式和个性化进行试验,以确定提高项目效果的方法。
{"title":"Have parenting programs for disruptive child behavior become less effective?","authors":"Patty Leijten,&nbsp;G.J. Melendez-Torres,&nbsp;Sophia Backhaus,&nbsp;Frances Gardner,&nbsp;Annabeth P. Groenman,&nbsp;Tycho J. Dekkers,&nbsp;Barbara J. van den Hoofdakker,&nbsp;Liina Björg Laas Sigurðardóttir,&nbsp;Danni Liu,&nbsp;Marjolein Luman,&nbsp;Lara Mansur,&nbsp;Merlin Nieterau,&nbsp;Saskia van der Oord,&nbsp;Geertjan Overbeek,&nbsp;Constantina Psyllou,&nbsp;Karen Rienks,&nbsp;Susanne Schulz,&nbsp;John R. Weisz","doi":"10.1111/jcpp.70049","DOIUrl":"10.1111/jcpp.70049","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Behavioral parenting programs have been exhaustively studied over the past five decades. We used this wealth of research to examine how estimates of parenting program effects have evolved over time, and if any time trends in effect estimates can be explained by trial, sample, or intervention characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We based our meta-analysis on a systematic search of 22 international and regional databases, gray literature, and 4 trial registries for randomized controlled trials of behavioral parenting programs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified 244 eligible trials (1,100 effect sizes; 28,916 families) from 36 countries. Parenting program effects initially reduced and then stabilized. More recent trials used more rigorous methods (e.g., more active control conditions and less risk of bias), samples that were generally older and included more girls, and evaluated interventions that on average had fewer sessions, were more often delivered by independent staff and made less use of time-out. However, none of these developments explained the initial reduction in effect size estimates during the first decades.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings suggest that estimates of parenting program effects are currently stable: Effect sizes are no longer reducing but there is also no evidence of increases over time. Experimentation with the content, delivery, and personalization of parenting programs is needed to identify ways to increase program effects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"67 1","pages":"127-137"},"PeriodicalIF":7.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://acamh.onlinelibrary.wiley.com/doi/epdf/10.1111/jcpp.70049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychostimulant treatment uniquely reduces left uncinate fasciculus microstructural integrity in ADHD youth with a familial risk for bipolar I disorder: a 12-week DTI study. 精神兴奋剂治疗独特地降低了具有双相I型障碍家族性风险的ADHD青年左钩叶束微结构完整性:一项为期12周的DTI研究。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-17 DOI: 10.1111/jcpp.70053
Kun Qin,Wen Chen,Du Lei,Ziyu Zhu,Maxwell J Tallman,Nanfang Pan,Lisha Zhang,Luis Rodrigo Patino,John A Sweeney,Melissa P DelBello,Robert K McNamara
BACKGROUNDBipolar I disorder (BD) is associated with reduced white matter microstructural integrity in the uncinate fasciculus (UF), a primary fiber tract connecting frontolimbic systems. Although familial history for BD, attention-deficit/hyperactivity disorder (ADHD), and psychostimulants are important risk factors implicated in BD pathoetiology, their impact on UF microstructure remains poorly understood.METHODSThis diffusion tensor imaging study investigated UF microstructural integrity prior to and following 12 weeks of psychostimulant treatment in ADHD youth with ('high-risk', HR) and without ('low-risk', LR) a first-degree relative with BD. Healthy controls were included for comparative purposes. LR youth received 12-week open-label mixed amphetamine salts-extended release (MAS-XR), and HR youth were randomized to either MAS-XR or placebo (PLA). Bilateral UF fractional anisotropy (FA) and axial diffusivity (AD) were assessed using automated fiber quantification.RESULTSA total of 137 participants were included in the analyses. At baseline, there were no significant group differences in bilateral UF microstructural metrics. Following 12-week MAS-XR treatment, significant group-by-time interactions were found for left UF FA and AD between HR-MAS and LR-MAS, as well as for left UF FA between HR-MAS and HR-PLA. Specifically, left UF FA and UF AD decreased significantly in HR-MAS but remained unchanged in LR-MAS and HR-PLA groups. At week 12, left UF FA was lower in HR-MAS relative to HC but not in LR-MAS or HR-PLA. Segment-wise analyses further revealed that UF microstructural changes in the HR-MAS group were localized to the anterior segments.CONCLUSIONSThese results suggest that HR-ADHD youth are uniquely vulnerable to reductions in left UF microstructural integrity following psychostimulant treatment, suggesting potential relevance to BD pathoprogression.
双相I型障碍(BD)与钩侧束(UF)白质微结构完整性降低有关,钩侧束是连接额叶系统的初级纤维束。虽然双相障碍家族史、注意缺陷/多动障碍(ADHD)和精神兴奋剂是双相障碍病理的重要危险因素,但它们对UF微观结构的影响尚不清楚。方法:本弥散张量成像研究调查了患有双相障碍的一级亲属(“高风险”,HR)和未患有双相障碍的一级亲属(“低风险”,LR)的ADHD青少年在接受精神兴奋剂治疗前后12周的UF显微结构完整性。LR青年接受为期12周的开放标签混合安非他明盐缓释(MAS-XR), HR青年随机接受MAS-XR或安慰剂(PLA)。双侧UF分数各向异性(FA)和轴向扩散率(AD)采用自动纤维定量评估。结果共纳入137名受试者。基线时,两组间双侧UF显微结构指标无显著差异。经过12周的MAS-XR治疗,发现HR-MAS和LR-MAS之间的左UF FA和AD,以及HR-MAS和HR-PLA之间的左UF FA显着的组时间相互作用。其中,左UF FA和UF AD在HR-MAS组显著降低,但在LR-MAS组和HR-PLA组保持不变。在第12周,左UF FA在HR-MAS相对于HC较低,但在LR-MAS或HR-PLA中没有。节段分析进一步显示,HR-MAS组的UF微结构变化局限于前节段。这些结果表明,HR-ADHD青少年在接受精神兴奋剂治疗后,特别容易受到左UF微结构完整性降低的影响,这可能与双相障碍的发病进展有关。
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引用次数: 0
Long-term follow-up of a randomised controlled trial of a brief home-based parenting intervention to reduce behavioural problems in young children. 一项随机对照试验的长期随访研究,以家庭为基础的短期父母干预来减少幼儿的行为问题。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-17 DOI: 10.1111/jcpp.70037
Paul Ramchandani,Jack Elkes,Victoria Cornelius,Sarah Byford,Laura Oxley,Daphne Babalis,Beth Barker,Erin Bibby,Brittney Chere,Poushali Ganguli,Sam Griffith,Zaheema Iqbal,Aiman Kamarudin,Katie Lui,Stephen Scott,Emma Tassie,Essi Viding,Christine O'Farrelly
BACKGROUNDBehaviour problems are common in childhood and are associated with higher rates of mental health problems, educational and relationship difficulties throughout life. This study assessed whether a Video-feedback Intervention to promote Positive Parenting and Sensitive Discipline (VIPP-SD) has sustained benefit 6 years after delivery. It had previously been shown to reduce behavioural problems in children aged 2 and 4 years old.METHODSThe Healthy Start, Happy Start study was a 2-arm, multisite randomised clinical trial conducted in 6 NHS trusts in England. Participants (N = 300) were parents/caregivers of children (aged 12-36 months) at risk of behaviour problems. Participants were randomised to receive either VIPP-SD (n = 151) or usual care (n = 149). Those allocated to VIPP-SD were offered 6 home-based video-feedback sessions. Six-year follow-up data were collected from May 2022 to July 2023. The primary outcome was the total score on Parental Account of Children's Symptoms (PACS). The analysis used prespecified longitudinal Bayesian models to handle missing data, and findings are reported as posterior probabilities of superiority alongside treatment effect estimates with 95% credible interval.RESULTSAnalysis included 294 of the 300 participants, with 6-year primary outcome data available for 244/300 (81%) (106 girls [43%]; mean age, 8.2 years). The probability of superiority for VIPP-SD on PACS was 86%. The mean difference in the total PACS score was -1.23 (95% Cred.I [-3.34, 0.90]); d = -0.11 (95% Cred.I [-0.032, 0.09]), with fewer behavioural problems in children in the VIPP-SD group (mean [SD] score of 25.30 [9.63] vs. 26.36 [11.05]).CONCLUSIONSThis trial found a probability of 86% that VIPP-SD was superior for reducing behaviour problems in children up to 6 years later. Taken together with the earlier positive trial findings, this suggests a small enduring positive impact of a brief early intervention with potential for scaling.
背景:行为问题在儿童时期很常见,并与一生中较高的心理健康问题、教育和人际关系困难有关。本研究评估了视频反馈干预促进积极育儿和敏感管教(VIPP-SD)是否在分娩后6年持续受益。之前的研究表明,它可以减少2岁和4岁儿童的行为问题。方法“健康开始,快乐开始”研究是一项在英国6家NHS信托机构进行的两组、多地点随机临床试验。参与者(N = 300)是有行为问题风险的儿童(12-36个月)的父母/照顾者。参与者被随机分配接受VIPP-SD (n = 151)或常规护理(n = 149)。分配到VIPP-SD的学生进行了6次家庭视频反馈。从2022年5月至2023年7月收集了六年的随访数据。主要结局是父母儿童症状报告(PACS)的总分。分析使用预先指定的纵向贝叶斯模型来处理缺失数据,研究结果报告为后验优势概率和治疗效果估计,可信区间为95%。结果纳入了300名参与者中的294名,其中244名(81%)有6年的主要结局数据(106名女孩[43%],平均年龄8.2岁)。VIPP-SD在PACS上的优势概率为86%。总PACS评分的平均差异为-1.23 (95% credit。I [-3.34, 0.90]);d = -0.11 (95%)I [-0.032, 0.09]), VIPP-SD组儿童的行为问题较少(平均[SD]评分为25.30[9.63]对26.36[11.05])。结论:该试验发现,在减少儿童6年后的行为问题方面,VIPP-SD的成功率为86%。结合早期的积极试验结果,这表明短暂的早期干预具有小规模的持久积极影响,并有可能扩大规模。
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引用次数: 0
Unraveling psychosis risk in sexual minorities: temporal dynamics of social defeat and suspiciousness in adolescence 揭示性少数群体的精神病风险:青春期社会失败和怀疑的时间动态。
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-10 DOI: 10.1111/jcpp.70042
Margaux Sageot, Robin Achterhof, Anu P. Hiekkaranta, Aleksandra Lecei, Kristof Vansteeland, Inez Myin-Germeys, Ruud van Winkel

Background

Previous research suggests that sexual minorities are at higher risk for psychotic experiences, possibly due to repeated social defeat experiences. However, empirical research investigating this hypothesis is largely lacking. This study examined how experiences of “feeling excluded” and “not belonging” impact the prospective development of psychotic experiences in an adolescent sexual minority group, defined here as non-heterosexual attraction to others.

Methods

Experience sampling method (ESM) data from 1913 Flemish adolescents (aged 11–20) in the SIGMA study were analyzed. They reported their momentary feelings of exclusion when alone, belonging when in the company of others (both operationalizations of social defeat), and suspiciousness. Multilevel linear regression models tested the bidirectional, within- and between-person associations between social defeat and suspiciousness, and the effects of sexual minority status.

Results

Lower feelings of belonging when in company significantly predicted higher suspiciousness at the next beep [95% CI: −0.03, −0.01], whereas increased feelings of exclusion when alone did not. Moreover, suspiciousness did not significantly predict feelings of exclusion and belonging at the next beep, confirming the direction of effect. Sexual minority participants reported generally lower belonging in social settings [95% CI: −0.68, −0.29] and higher suspiciousness [95% CI: 0.16, 0.57], but not higher feelings of exclusion. The interaction between social defeat and sexual minority status was not significant, indicating no differential sensitivity to social defeat experiences.

Conclusions

The experience of “not fitting in” when in company may be the most poignant social factor increasing risk for psychotic experiences in sexual minority youth. The findings highlight the need for inclusive environments where sexual minority individuals feel supported and integrated.

之前的研究表明,性少数群体患精神病的风险更高,可能是由于反复的社会失败经历。然而,调查这一假设的实证研究在很大程度上是缺乏的。本研究考察了“感觉被排斥”和“不属于”的经历如何影响青少年性少数群体精神病经历的未来发展,这里定义为对他人的非异性恋吸引力。方法采用经验抽样法(ESM)对1913例11 ~ 20岁佛兰德青少年的SIGMA研究数据进行分析。他们报告了独处时的短暂排斥感,和其他人在一起时的归属感(都是社会失败的操作化),以及怀疑感。多水平线性回归模型检验了社会失败与怀疑之间的双向、内部和人与人之间的联系,以及性少数地位的影响。结果:与同伴在一起时,较低的归属感显著预示着下一次蜂鸣声时较高的疑心[95% CI: -0.03, -0.01],而独自一人时,较高的排斥感则无此影响。此外,怀疑并不能显著预测下一次哔哔声时的排斥感和归属感,证实了效应的方向。性少数参与者普遍报告在社会环境中较低的归属感[95% CI: -0.68, -0.29]和较高的怀疑[95% CI: 0.16, 0.57],但没有较高的排斥感。社会失败与性少数身份之间的交互作用不显著,表明对社会失败经历的敏感性不存在差异。结论与人交往时的“不适应”体验可能是增加性少数青少年精神病经历风险的最尖锐的社会因素。研究结果强调,需要一个包容的环境,让性少数群体感到得到支持和融入。
{"title":"Unraveling psychosis risk in sexual minorities: temporal dynamics of social defeat and suspiciousness in adolescence","authors":"Margaux Sageot,&nbsp;Robin Achterhof,&nbsp;Anu P. Hiekkaranta,&nbsp;Aleksandra Lecei,&nbsp;Kristof Vansteeland,&nbsp;Inez Myin-Germeys,&nbsp;Ruud van Winkel","doi":"10.1111/jcpp.70042","DOIUrl":"10.1111/jcpp.70042","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Previous research suggests that sexual minorities are at higher risk for psychotic experiences, possibly due to repeated social defeat experiences. However, empirical research investigating this hypothesis is largely lacking. This study examined how experiences of “feeling excluded” and “not belonging” impact the prospective development of psychotic experiences in an adolescent sexual minority group, defined here as non-heterosexual attraction to others.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Experience sampling method (ESM) data from 1913 Flemish adolescents (aged 11–20) in the SIGMA study were analyzed. They reported their momentary feelings of exclusion when alone, belonging when in the company of others (both operationalizations of social defeat), and suspiciousness. Multilevel linear regression models tested the bidirectional, within- and between-person associations between social defeat and suspiciousness, and the effects of sexual minority status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Lower feelings of belonging when in company significantly predicted higher suspiciousness at the next beep [95% CI: −0.03, −0.01], whereas increased feelings of exclusion when alone did not. Moreover, suspiciousness did not significantly predict feelings of exclusion and belonging at the next beep, confirming the direction of effect. Sexual minority participants reported generally lower belonging in social settings [95% CI: −0.68, −0.29] and higher suspiciousness [95% CI: 0.16, 0.57], but not higher feelings of exclusion. The interaction between social defeat and sexual minority status was not significant, indicating no differential sensitivity to social defeat experiences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The experience of “not fitting in” when in company may be the most poignant social factor increasing risk for psychotic experiences in sexual minority youth. The findings highlight the need for inclusive environments where sexual minority individuals feel supported and integrated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":187,"journal":{"name":"Journal of Child Psychology and Psychiatry","volume":"67 2","pages":"296-304"},"PeriodicalIF":7.0,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emotional and behavioural difficulties in gender minority compared to cisgender adolescents: identity specific findings from a contemporary national study. 与顺性青少年相比,性别少数群体的情感和行为困难:来自当代国家研究的身份特异性发现。
IF 7.6 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-10 DOI: 10.1111/jcpp.70050
Nicholas Page,Lianna Angel,Sophie Borgia,Colleen Reynolds,Dougie Zubizarreta,Honor Young,Max R Ashton,James White
BACKGROUNDGender minority adolescents are more likely to report emotional and behavioural difficulties compared to their cisgender peers. However, little is known about these experiences for adolescents with specific gender minority identities.METHODSCross-sectional data were obtained from the 2021/22 Student Health and Well-being survey, a national survey of 11-16-year-olds in Wales, UK. Emotional and behavioural difficulties were measured using the Strengths and Difficulties Questionnaire. Gender identity and assigned sex at birth were self-reported. Multivariable linear regressions with robust standard errors were used to examine associations between gender identity and emotional and behavioural difficulties, adjusting for age, ethnicity, household-level affluence and correction for multiple testing.RESULTSOf the 122,766 participants, 2.0% (2,455) identified as a person with a gender minority identity. Twenty-eight gender minority identities were self-reported, with the most prevalent being transgender boy and nonbinary assigned female at birth (both 0.6%). Young people assigned female at birth comprised 80% of gender minority adolescents. In the adjusted model, emotional and behavioural difficulties were reported most frequently by people who identified as non-binary (B = 7.66, 95% CI 7.25, 8.06) and another gender identity (B = 7.86, 95% CI 7.34, 8.38), then transgender (B = 5.05, 95% CI 4.58, 5.51), when compared to cisgender adolescents. Female sex assigned at birth was associated with more reported difficulties than male sex assigned at birth for adolescents with a transgender or cisgender identity, but not a nonbinary identity.CONCLUSIONSIn this population-based study, emotional and behavioural difficulties were reported most frequently by adolescents who identified as nonbinary and another gender identity, then transgender, then cisgender. Health and educational practitioners need to be aware that emotional and behavioural difficulties differ across gender minority identities.
背景:与顺性别同龄人相比,少数性别青少年更有可能报告情感和行为上的困难。然而,对于具有特定性别少数认同的青少年的这些经历,我们知之甚少。方法横断面数据来自2021/22学生健康与幸福调查,这是一项针对英国威尔士11-16岁学生的全国性调查。使用优势和困难问卷测量情绪和行为困难。出生时的性别认同和生理性别都是自我报告的。使用具有稳健标准误差的多变量线性回归来检查性别认同与情感和行为困难之间的关联,调整年龄、种族、家庭富裕程度,并对多重测试进行校正。结果在122,766名参与者中,2.0%(2,455人)认为自己是性别少数群体。28个性别少数认同是自我报告的,最普遍的是变性男孩和出生时非二元性别分配的女性(均为0.6%)。出生时被指定为女性的青少年占性别少数群体青少年的80%。在调整后的模型中,与顺性青少年相比,被认定为非二元(B = 7.66, 95% CI 7.25, 8.06)和另一性别认同(B = 7.86, 95% CI 7.34, 8.38)的人最常报告情绪和行为困难,然后是跨性别(B = 5.05, 95% CI 4.58, 5.51)。对于具有跨性别或顺性别认同的青少年来说,出生时性别分配的女性比出生时性别分配的男性有更多的困难,而非二元认同的青少年则没有。结论:在这项以人群为基础的研究中,情绪和行为困难最常见于非二元性和其他性别认同的青少年,其次是跨性别者,然后是顺性别者。保健和教育从业人员需要认识到,情感和行为困难因性别少数群体身份而异。
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引用次数: 0
Mid-childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder 有自闭症和/或注意缺陷多动障碍家族史的婴儿的童年中期发育和行为结果
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-09 DOI: 10.1111/jcpp.70048
Tony Charman, Tessel Bazelmans, Greg Pasco, Jannath Begum Ali, Mark H. Johnson, Emily J. H. Jones, The BASIS/STAARS Team

Background

Prospective studies of autism family history infants primarily report recurrence and predictors of autism at 3 years. Less is known about ADHD family history infants and later childhood outcomes. We characterise profiles of mid-childhood developmental and behavioural outcomes in infants with a family history of autism and/or ADHD to identify potential support needs and patterns of co-occurrence across domains.

Methods

Two hundred and sixty-three infants (51% male; N = 198 autism/ADHD family history; N = 65 no family history) were assessed at 6–12 years. A latent profile analysis (LPA) with indicator variables measuring developmental abilities (IQ, adaptive function) and behavioural traits (autism, ADHD, anxiety) identified dimensional, data-derived outcome classes.

Results

A seven-class solution was the most robust and clinically meaningful. Two classes (27% and 23%) had typical development; two classes had high autism, ADHD, and anxiety traits—one with low IQ and adaptive function (10%) and one with average IQ but low adaptive function (13%); one class had elevated autism and ADHD but not anxiety traits (10%); and the final two classes had elevated ADHD (9%) and anxiety (8%) traits in isolation. Sex distribution was balanced across all classes. Children with autism were found in all classes but predominantly in the classes with low IQ/adaptive functioning and high behavioural traits, as well as in the class with elevated autism and ADHD traits. We found only partial continuity between membership of similarly derived 3-year LPA classes and mid-childhood LPA classes.

Conclusions

Many autism/ADHD family history infants develop typically. However, by mid-childhood, in addition to those with autism, others show elevated neurodevelopmental (autism, ADHD) and neuropsychiatric (anxiety) behavioural traits. Lower developmental abilities (IQ and adaptive function) are primarily seen in children with an autism diagnosis. Family history infants should be monitored through childhood, and support provided should challenges emerge.

背景:对自闭症家族史婴儿的前瞻性研究主要报告了3岁时自闭症的复发和预测因素。对于多动症的家族史,婴儿和儿童后期的结果,我们所知较少。我们对有自闭症和/或ADHD家族史的婴儿的童年中期发育和行为结果进行特征描述,以确定潜在的支持需求和跨领域共发生的模式。方法对6-12岁的263名婴儿进行评估,其中男性占51%,有自闭症/ADHD家族史的198例,无家族史的65例。潜在轮廓分析(LPA)与指标变量测量发展能力(智商,适应功能)和行为特征(自闭症,多动症,焦虑)确定维度,数据派生的结果类别。结果tsa 7级溶液稳健性最强,具有临床意义。两类(27%和23%)发展典型;两类具有高自闭症、多动症和焦虑特征——一类具有低智商和低适应功能(10%),另一类具有平均智商但低适应功能(13%);一个班级的自闭症和注意力缺陷多动症升高,但没有焦虑特征(10%);最后两类单独出现ADHD(9%)和焦虑(8%)特征升高。性别分布在所有阶层中都是平衡的。所有班级都有自闭症儿童,但主要出现在智商/适应功能低、行为特征高的班级,以及自闭症和多动症特征较高的班级。我们发现类似衍生的3年LPA班级和儿童中期LPA班级的成员之间只有部分连续性。结论许多有自闭症/ADHD家族史的婴儿发育典型。然而,到了儿童中期,除了那些患有自闭症的人,其他人表现出神经发育(自闭症、多动症)和神经精神(焦虑)行为特征的升高。较低的发展能力(智商和适应功能)主要见于被诊断为自闭症的儿童。有家族史的婴儿应该在童年时期进行监测,并在出现挑战时提供支持。
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引用次数: 0
Editorial: Supporting families in the first 1,000 days of life – a balancing act 社论:在生命最初的1000天里支持家庭——一种平衡的行为。
IF 7 1区 医学 Q1 PSYCHIATRY Pub Date : 2025-09-08 DOI: 10.1111/jcpp.70041
Maartje P.C.M. Luijk, Tessa J. Roseboom

From the moment of fertilization, human development takes a phenomenal pace. In no other period of life are more biological and developmental milestones met than in the first 1,000 days after conception. All organs and systems are formed, and children start to discover the world, learn whom to trust and where to find comfort in times of distress. Evidence from biological, psychological, social and economic research shows that the environment in the first 1,000 days significantly impacts a person's ability to reach their full potential. Children who grow up in unpredictable and unsafe environments often struggle with the consequences for the rest of their lives. Investments in this critical period of human development have proven to be the most cost-effective way to improve lifelong health and well-being. Therefore, this period has gained interest both in political debate and society at large. In this contribution, we demonstrate that while the focus on the first 1,000 days is scientifically sound and historically grounded, it is time to reflect on its societal impact. We focus on its unintended negative consequences for parental well-being. Evidence for the importance of the first 1,000 days should drive collective action rather than reinforce individual blame. Parenting is not just a private matter; governments have a duty to provide parents with the resources to give their children the best start in life.

从受精的那一刻起,人类就以惊人的速度发展。怀孕后的头1000天是生命中最具生物学和发育里程碑的时期。所有的器官和系统都形成了,孩子们开始发现世界,学会信任谁,在痛苦的时候去哪里寻找安慰。来自生物学、心理学、社会和经济研究的证据表明,人生最初1000天的环境对一个人充分发挥潜力的能力有重大影响。在不可预测和不安全的环境中长大的儿童往往会在其余生中与这些后果作斗争。事实证明,在人类发展的这一关键时期进行投资是改善终身健康和福祉的最具成本效益的方式。因此,这一时期在政治辩论和整个社会都引起了人们的兴趣。在这篇文章中,我们证明,虽然对前1000天的关注在科学上是合理的,并且有历史依据,但现在是时候反思其社会影响了。我们关注的是它对父母幸福的意想不到的负面影响。证明前1000天重要性的证据应该推动集体行动,而不是强化个人指责。养育子女不仅仅是一件私事;政府有责任为父母提供资源,让他们的孩子有一个最好的人生开端。
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引用次数: 0
期刊
Journal of Child Psychology and Psychiatry
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