Pub Date : 2025-01-10DOI: 10.1038/d41586-025-00027-0
Meta’s planned shift away from third party fact-checking in favour of a crowdsourced approach has perplexed those who study the spread of misinformation.
{"title":"Facebook to ditch fact-checking: what do researchers think?","authors":"","doi":"10.1038/d41586-025-00027-0","DOIUrl":"https://doi.org/10.1038/d41586-025-00027-0","url":null,"abstract":"Meta’s planned shift away from third party fact-checking in favour of a crowdsourced approach has perplexed those who study the spread of misinformation.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"9 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-10DOI: 10.1038/d41586-025-00067-6
The Nobel prizewinner worked tirelessly with wife Rosalynn Carter to eradicate Guinea-worm disease.
{"title":"Jimmy Carter obituary: former US president who dedicated his life after office to peace, human rights and global health","authors":"","doi":"10.1038/d41586-025-00067-6","DOIUrl":"https://doi.org/10.1038/d41586-025-00067-6","url":null,"abstract":"The Nobel prizewinner worked tirelessly with wife Rosalynn Carter to eradicate Guinea-worm disease.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"24 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1038/d41586-025-00008-3
Sensory organs on the walking legs of the male wasp spider can catch the scent of a female in a mood for romance.
{"title":"Male spiders smell with their legs","authors":"","doi":"10.1038/d41586-025-00008-3","DOIUrl":"https://doi.org/10.1038/d41586-025-00008-3","url":null,"abstract":"Sensory organs on the walking legs of the male wasp spider can catch the scent of a female in a mood for romance.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"84 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1038/d41586-025-00021-6
Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.
{"title":"Who’s quitting academia? Data reveal gender gaps in surprising fields","authors":"","doi":"10.1038/d41586-025-00021-6","DOIUrl":"https://doi.org/10.1038/d41586-025-00021-6","url":null,"abstract":"Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"118 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1038/d41586-025-00012-7
Previously undescribed cells look like fat cells, but they function to provide cushioning and support in cartilage.
{"title":"Revealed: the fatty cells that are the ‘bubble wrap’ of the body","authors":"","doi":"10.1038/d41586-025-00012-7","DOIUrl":"https://doi.org/10.1038/d41586-025-00012-7","url":null,"abstract":"Previously undescribed cells look like fat cells, but they function to provide cushioning and support in cartilage.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"20 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1038/d41586-025-00013-6
Pharmaceuticals and vector-control programmes have greatly diminished the once-widespread disease, but sustained effort will be needed to stamp out infection for good.
{"title":"Why the last cases of sleeping sickness will be the hardest to eliminate","authors":"","doi":"10.1038/d41586-025-00013-6","DOIUrl":"https://doi.org/10.1038/d41586-025-00013-6","url":null,"abstract":"Pharmaceuticals and vector-control programmes have greatly diminished the once-widespread disease, but sustained effort will be needed to stamp out infection for good.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"204 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1038/d41586-025-00048-9
We learn how the brain ‘washes’ itself while asleep and meet two fossils that are changing our understanding of mollusc evolution.
{"title":"Daily briefing: Meet Punk and Emo, the 430-million-year old mollusc fossils","authors":"","doi":"10.1038/d41586-025-00048-9","DOIUrl":"https://doi.org/10.1038/d41586-025-00048-9","url":null,"abstract":"We learn how the brain ‘washes’ itself while asleep and meet two fossils that are changing our understanding of mollusc evolution.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"9 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1038/s41586-024-08577-5
Mathi Thiruppathy, Lauren Teubner, Ryan R. Roberts, Micaela Lasser, Alessandra Moscatello, Ya-Wen Chen, Christian Hochstim, Seth Ruffins, Arijita Sarkar, Jade Tassey, Denis Evseenko, Thomas P. Lozito, Helen Rankin Willsey, J. Andrew Gillis, J. Gage Crump
How novel structures emerge during evolution has long fascinated biologists. A dramatic example is how the diminutive bones of the mammalian middle ear arose from ancestral fish jawbones1. In contrast, the evolutionary origin of the outer ear, another mammalian innovation, remains a mystery, in part because it is supported by non-mineralized elastic cartilage rarely recovered in fossils. Whether the outer ear arose de novo or through reuse of ancestral developmental programs is unknown. Here we show that the outer ear shares gene regulatory programs with the gills of fishes and amphibians for both its initial outgrowth and later development of elastic cartilage. Comparative single-nuclei multiomics of the human outer ear and zebrafish gills reveals conserved gene expression and putative enhancers enriched for common transcription factor binding motifs. This is reflected by transgenic activity of human outer ear enhancers in gills, and fish gill enhancers in the outer ear. Further, single-cell multiomics of the cartilaginous book gills of horseshoe crabs reveal a shared DLX-mediated gill program with vertebrates, with a book gill distalless enhancer driving expression in zebrafish gills. We propose that elements of an invertebrate gill program were reutilized in vertebrates to generate first gills and then the outer ear.
{"title":"Repurposing of a gill gene regulatory program for outer ear evolution","authors":"Mathi Thiruppathy, Lauren Teubner, Ryan R. Roberts, Micaela Lasser, Alessandra Moscatello, Ya-Wen Chen, Christian Hochstim, Seth Ruffins, Arijita Sarkar, Jade Tassey, Denis Evseenko, Thomas P. Lozito, Helen Rankin Willsey, J. Andrew Gillis, J. Gage Crump","doi":"10.1038/s41586-024-08577-5","DOIUrl":"https://doi.org/10.1038/s41586-024-08577-5","url":null,"abstract":"<p>How novel structures emerge during evolution has long fascinated biologists. A dramatic example is how the diminutive bones of the mammalian middle ear arose from ancestral fish jawbones<sup>1</sup>. In contrast, the evolutionary origin of the outer ear, another mammalian innovation, remains a mystery, in part because it is supported by non-mineralized elastic cartilage rarely recovered in fossils. Whether the outer ear arose de novo or through reuse of ancestral developmental programs is unknown. Here we show that the outer ear shares gene regulatory programs with the gills of fishes and amphibians for both its initial outgrowth and later development of elastic cartilage. Comparative single-nuclei multiomics of the human outer ear and zebrafish gills reveals conserved gene expression and putative enhancers enriched for common transcription factor binding motifs. This is reflected by transgenic activity of human outer ear enhancers in gills, and fish gill enhancers in the outer ear. Further, single-cell multiomics of the cartilaginous book gills of horseshoe crabs reveal a shared DLX-mediated gill program with vertebrates, with a book gill <i>distalless</i> enhancer driving expression in zebrafish gills. We propose that elements of an invertebrate gill program were reutilized in vertebrates to generate first gills and then the outer ear.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"39 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1038/s41586-024-08560-0
Andrew Moorman, Elizabeth K. Benitez, Francesco Cambuli, Qingwen Jiang, Ahmed Mahmoud, Melissa Lumish, Saskia Hartner, Sasha Balkaran, Jonathan Bermeo, Simran Asawa, Canan Firat, Asha Saxena, Fan Wu, Anisha Luthra, Cassandra Burdziak, Yubin Xie, Valeria Sgambati, Kathleen Luckett, Yanyun Li, Zhifan Yi, Ignas Masilionis, Kevin Soares, Emmanouil Pappou, Rona Yaeger, T. Peter Kingham, William Jarnagin, Philip B. Paty, Martin R. Weiser, Linas Mazutis, Michael D’Angelica, Jinru Shia, Julio Garcia-Aguilar, Tal Nawy, Travis J. Hollmann, Ronan Chaligné, Francisco Sanchez-Vega, Roshan Sharma, Dana Pe’er, Karuna Ganesh
Correction to: Nature https://doi.org/10.1038/s41586-024-08150-0 Published online 30 October 2024
{"title":"Author Correction: Progressive plasticity during colorectal cancer metastasis","authors":"Andrew Moorman, Elizabeth K. Benitez, Francesco Cambuli, Qingwen Jiang, Ahmed Mahmoud, Melissa Lumish, Saskia Hartner, Sasha Balkaran, Jonathan Bermeo, Simran Asawa, Canan Firat, Asha Saxena, Fan Wu, Anisha Luthra, Cassandra Burdziak, Yubin Xie, Valeria Sgambati, Kathleen Luckett, Yanyun Li, Zhifan Yi, Ignas Masilionis, Kevin Soares, Emmanouil Pappou, Rona Yaeger, T. Peter Kingham, William Jarnagin, Philip B. Paty, Martin R. Weiser, Linas Mazutis, Michael D’Angelica, Jinru Shia, Julio Garcia-Aguilar, Tal Nawy, Travis J. Hollmann, Ronan Chaligné, Francisco Sanchez-Vega, Roshan Sharma, Dana Pe’er, Karuna Ganesh","doi":"10.1038/s41586-024-08560-0","DOIUrl":"https://doi.org/10.1038/s41586-024-08560-0","url":null,"abstract":"<p>Correction to: <i>Nature</i> https://doi.org/10.1038/s41586-024-08150-0 Published online 30 October 2024</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"23 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-08DOI: 10.1038/s41586-024-08451-4
Talyn Chu, Ming Wu, Barbara Hoellbacher, Gustavo P. de Almeida, Christine Wurmser, Jacqueline Berner, Lara V. Donhauser, Gerullis Ann-Katrin, Siran Lin, J. Diego Cepeda-Mayorga, Iman I. Kilb, Lukas Bongers, Fabio Toppeta, Philipp Strobl, Ben Youngblood, Anna M. Schulz, Alfred Zippelius, Percy A. Knolle, Matthias Heinig, Carl-Philipp Hackstein, Dietmar Zehn
T cell exhaustion limits effector T cell function in chronic infection and tumors1,2. The development of these hypofunctional T cells and of their precursors was considered to require stimulatory conditions met only upon persisting exposure to antigen and inflammation. In sharp contrast, we found similar T cell populations in the early phase of acute infections1,2. At that stage early developing TCF1+ precursor population shows an unexpected diversity, which includes precursors of normal memory T cells but also cells with a phenotype, gene-expression, and epigenetic profile that resembles precursors of exhausted T cells found in chronic infections. We demonstrate that high ligand affinity promotes, and PD-1 signaling restricts the development of these precursors. While these exhausted precursors are initially frequently found, they decline without being completely lost in infections the immune system resolves. We therefore concluded that precursor T cells with at least two distinct phenotypes are preemptively generated irrespectively of the outcome of the infection.
{"title":"Precursors of exhausted T cells are preemptively formed in acute infection","authors":"Talyn Chu, Ming Wu, Barbara Hoellbacher, Gustavo P. de Almeida, Christine Wurmser, Jacqueline Berner, Lara V. Donhauser, Gerullis Ann-Katrin, Siran Lin, J. Diego Cepeda-Mayorga, Iman I. Kilb, Lukas Bongers, Fabio Toppeta, Philipp Strobl, Ben Youngblood, Anna M. Schulz, Alfred Zippelius, Percy A. Knolle, Matthias Heinig, Carl-Philipp Hackstein, Dietmar Zehn","doi":"10.1038/s41586-024-08451-4","DOIUrl":"https://doi.org/10.1038/s41586-024-08451-4","url":null,"abstract":"<p>T cell exhaustion limits effector T cell function in chronic infection and tumors<sup>1,2</sup>. The development of these hypofunctional T cells and of their precursors was considered to require stimulatory conditions met only upon persisting exposure to antigen and inflammation. In sharp contrast, we found similar T cell populations in the early phase of acute infections<sup>1,2</sup>. At that stage early developing TCF1<sup>+</sup> precursor population shows an unexpected diversity, which includes precursors of normal memory T cells but also cells with a phenotype, gene-expression, and epigenetic profile that resembles precursors of exhausted T cells found in chronic infections. We demonstrate that high ligand affinity promotes, and PD-1 signaling restricts the development of these precursors. While these exhausted precursors are initially frequently found, they decline without being completely lost in infections the immune system resolves. We therefore concluded that precursor T cells with at least two distinct phenotypes are preemptively generated irrespectively of the outcome of the infection.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"24 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142937192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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