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From farm to pharmacy: gene-edited plants produce a popular supplement
IF 64.8 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nature
Pub Date : 2025-02-13 DOI: 10.1038/d41586-025-00401-y
Widely grown crops can be bioengineered to make a form of coenzyme Q taken by people seeking a health boost.
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引用次数: 0
Quantum-computing technology that makes qubits from atoms wins mega investment.
IF 50.5 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nature
Pub Date : 2025-02-13 DOI: 10.1038/d41586-025-00451-2
Elizabeth Gibney
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引用次数: 0
Daily briefing: A simple blood test could diagnose pancreatic cancer early
IF 64.8 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nature
Pub Date : 2025-02-13 DOI: 10.1038/d41586-025-00492-7
A new blood test could diagnose pancreatic cancer before it spreads. Plus, physicists have detected the highest-energy neutrino ever.
{"title":"Daily briefing: A simple blood test could diagnose pancreatic cancer early","authors":"","doi":"10.1038/d41586-025-00492-7","DOIUrl":"https://doi.org/10.1038/d41586-025-00492-7","url":null,"abstract":"A new blood test could diagnose pancreatic cancer before it spreads. Plus, physicists have detected the highest-energy neutrino ever.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"23 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Royal Society will meet amid campaign to revoke Elon Musk's fellowship.
IF 50.5 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nature
Pub Date : 2025-02-13 DOI: 10.1038/d41586-025-00486-5
Holly Else
{"title":"Royal Society will meet amid campaign to revoke Elon Musk's fellowship.","authors":"Holly Else","doi":"10.1038/d41586-025-00486-5","DOIUrl":"10.1038/d41586-025-00486-5","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":50.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scientists use AI to design life-like enzymes from scratch.
IF 50.5 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nature
Pub Date : 2025-02-13 DOI: 10.1038/d41586-025-00488-3
Miryam Naddaf
{"title":"Scientists use AI to design life-like enzymes from scratch.","authors":"Miryam Naddaf","doi":"10.1038/d41586-025-00488-3","DOIUrl":"https://doi.org/10.1038/d41586-025-00488-3","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":50.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are the Trump team’s actions affecting your research? How to contact Nature
IF 64.8 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nature
Pub Date : 2025-02-13 DOI: 10.1038/d41586-025-00479-4
Use this form to share information with Nature’s news team, or to make suggestions for future coverage.
{"title":"Are the Trump team’s actions affecting your research? How to contact Nature","authors":"","doi":"10.1038/d41586-025-00479-4","DOIUrl":"https://doi.org/10.1038/d41586-025-00479-4","url":null,"abstract":"Use this form to share information with Nature’s news team, or to make suggestions for future coverage.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"19 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: India–Eurasia convergence speed-up by passive-margin sediment subduction
IF 64.8 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nature
Pub Date : 2025-02-13 DOI: 10.1038/s41586-025-08762-0
Hao Zhou, Jiashun Hu, Luca Dal Zilio, Ming Tang, Keqing Li, Xiumian Hu

Correction to: Nature https://doi.org/10.1038/s41586-024-08069-6 Published online 6 November 2024

{"title":"Author Correction: India–Eurasia convergence speed-up by passive-margin sediment subduction","authors":"Hao Zhou, Jiashun Hu, Luca Dal Zilio, Ming Tang, Keqing Li, Xiumian Hu","doi":"10.1038/s41586-025-08762-0","DOIUrl":"https://doi.org/10.1038/s41586-025-08762-0","url":null,"abstract":"<p>Correction to: <i>Nature</i> https://doi.org/10.1038/s41586-024-08069-6 Published online 6 November 2024</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"20 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The researchers on a quest to protect the gut from antibiotics
IF 64.8 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nature
Pub Date : 2025-02-13 DOI: 10.1038/d41586-025-00477-6
The crucial drugs can have unintended consequences. Innovative therapies could shield the microbiome from their effects.
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引用次数: 0
Publisher Correction: Immune evasion through mitochondrial transfer in the tumour microenvironment
IF 64.8 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nature
Pub Date : 2025-02-13 DOI: 10.1038/s41586-025-08764-y
Hideki Ikeda, Katsushige Kawase, Tatsuya Nishi, Tomofumi Watanabe, Keizo Takenaga, Takashi Inozume, Takamasa Ishino, Sho Aki, Jason Lin, Shusuke Kawashima, Joji Nagasaki, Youki Ueda, Shinichiro Suzuki, Hideki Makinoshima, Makiko Itami, Yuki Nakamura, Yasutoshi Tatsumi, Yusuke Suenaga, Takao Morinaga, Akiko Honobe-Tabuchi, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yasuhiro Nakamura, Yukiko Kiniwa, Eiki Ichihara, Hidetoshi Hayashi, Jun-ichiro Ikeda, Toyoyuki Hanazawa, Shinichi Toyooka, Hiroyuki Mano, Takuji Suzuki, Tsuyoshi Osawa, Masahito Kawazu, Yosuke Togashi

Correction to: Nature https://doi.org/10.1038/s41586-024-08439-0 Published online 22 January 2025

{"title":"Publisher Correction: Immune evasion through mitochondrial transfer in the tumour microenvironment","authors":"Hideki Ikeda, Katsushige Kawase, Tatsuya Nishi, Tomofumi Watanabe, Keizo Takenaga, Takashi Inozume, Takamasa Ishino, Sho Aki, Jason Lin, Shusuke Kawashima, Joji Nagasaki, Youki Ueda, Shinichiro Suzuki, Hideki Makinoshima, Makiko Itami, Yuki Nakamura, Yasutoshi Tatsumi, Yusuke Suenaga, Takao Morinaga, Akiko Honobe-Tabuchi, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yasuhiro Nakamura, Yukiko Kiniwa, Eiki Ichihara, Hidetoshi Hayashi, Jun-ichiro Ikeda, Toyoyuki Hanazawa, Shinichi Toyooka, Hiroyuki Mano, Takuji Suzuki, Tsuyoshi Osawa, Masahito Kawazu, Yosuke Togashi","doi":"10.1038/s41586-025-08764-y","DOIUrl":"https://doi.org/10.1038/s41586-025-08764-y","url":null,"abstract":"<p>Correction to: <i>Nature</i> https://doi.org/10.1038/s41586-024-08439-0 Published online 22 January 2025</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"42 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
IF 64.8 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Nature
Pub Date : 2025-02-12 DOI: 10.1038/s41586-024-08532-4
Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie, Eunju Nam, N. Connor Payne, Pallavi M. Gosavi, Hui Si Kwok, Irtiza Iram, Ceejay Lee, Jiaming Li, Nicholas J. Chen, Khanh Nguyen, Hanjie Jiang, Zhipeng A. Wang, Kwangwoon Lee, Haibin Mao, Stefan A. Harry, Idris A. Barakat, Mariko Takahashi, Amanda L. Waterbury, Marco Barone, Andrea Mattevi, Steven A. Carr, Namrata D. Udeshi, Liron Bar-Peled, Philip A. Cole, Ralph Mazitschek, Brian B. Liau, Ning Zheng

UM171 is a potent agonist of ex vivo human haematopoietic stem cell self-renewal1. By co-opting KBTBD4, a substrate receptor of the CUL3–RING E3 ubiquitin ligase (CRL3) complex, UM171 promotes the degradation of the LSD1–CoREST corepressor complex, thereby limiting haematopoietic stem cell attrition2,3. However, the direct target and mechanism of action of UM171 remain unclear. Here we show that UM171 acts as a molecular glue to induce high-affinity interactions between KBTBD4 and HDAC1/2 to promote corepressor degradation. Through proteomics and chemical inhibitor studies, we identify the principal target of UM171 as HDAC1/2. Cryo-electron microscopy analysis of dimeric KBTBD4 bound to UM171 and the LSD1–HDAC1–CoREST complex identifies an asymmetric assembly in which a single UM171 molecule enables a pair of KELCH-repeat propeller domains to recruit the HDAC1 catalytic domain. One KBTBD4 propeller partially masks the rim of the HDAC1 active site, which is exploited by UM171 to extend the E3–neosubstrate interface. The other propeller cooperatively strengthens HDAC1 binding through a distinct interface. The overall CoREST–HDAC1/2–KBTBD4 interaction is further buttressed by the endogenous cofactor inositol hexakisphosphate, which acts as a second molecular glue. The functional relevance of the quaternary complex interaction surfaces is demonstrated by base editor scanning of KBTBD4 and HDAC1. By delineating the direct target of UM171 and its mechanism of action, we reveal how the cooperativity offered by a dimeric CRL3 E3 can be leveraged by a small molecule degrader.

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引用次数: 0
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