Pub Date : 2026-02-04DOI: 10.1038/s41586-025-10082-2
A. von Hoegen, T. Tai, C. J. Allington, M. Yeung, J. Pettine, M. H. Michael, E. Viñas Boström, X. Cui, K. Torres, A. E. Kossak, B. Lee, G. S. D. Beach, G. D. Gu, A. Rubio, P. Kim, N. Gedik
{"title":"Imaging a terahertz superfluid plasmon in a two-dimensional superconductor","authors":"A. von Hoegen, T. Tai, C. J. Allington, M. Yeung, J. Pettine, M. H. Michael, E. Viñas Boström, X. Cui, K. Torres, A. E. Kossak, B. Lee, G. S. D. Beach, G. D. Gu, A. Rubio, P. Kim, N. Gedik","doi":"10.1038/s41586-025-10082-2","DOIUrl":"https://doi.org/10.1038/s41586-025-10082-2","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"1 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1038/s41586-025-10065-3
Max W. Schmidt, Nadia Paneva, Andrea Giuliani
{"title":"A universal concept for melting in mantle upwellings","authors":"Max W. Schmidt, Nadia Paneva, Andrea Giuliani","doi":"10.1038/s41586-025-10065-3","DOIUrl":"https://doi.org/10.1038/s41586-025-10065-3","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"1 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1038/s41586-025-10093-z
Lucía Barbadilla-Martínez, Noud Klaassen, Vinícius H. Franceschini-Santos, Jérémie Breda, Hatice Yücel, Miguel Hernández-Quiles, Tijs van Lieshout, Carlos G. Urzua Traslaviña, Minh Chau Luong Boi, Maryam Akbarzadeh, Celia Hermana-Garcia-Agullo, Sebastian Gregoricchio, Marcel de Haas, Roy Straver, Sarah Derks, Wilbert Zwart, Emile Voest, Lude Franke, Michiel Vermeulen, Jeroen de Ridder, Bas van Steensel
{"title":"Regulatory grammar in human promoters uncovered by MPRA-based deep learning","authors":"Lucía Barbadilla-Martínez, Noud Klaassen, Vinícius H. Franceschini-Santos, Jérémie Breda, Hatice Yücel, Miguel Hernández-Quiles, Tijs van Lieshout, Carlos G. Urzua Traslaviña, Minh Chau Luong Boi, Maryam Akbarzadeh, Celia Hermana-Garcia-Agullo, Sebastian Gregoricchio, Marcel de Haas, Roy Straver, Sarah Derks, Wilbert Zwart, Emile Voest, Lude Franke, Michiel Vermeulen, Jeroen de Ridder, Bas van Steensel","doi":"10.1038/s41586-025-10093-z","DOIUrl":"https://doi.org/10.1038/s41586-025-10093-z","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"68 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1038/d41586-026-00361-x
Jacob Smith
{"title":"Daily briefing: What people with no ‘mind’s eye’ can tell us about consciousness","authors":"Jacob Smith","doi":"10.1038/d41586-026-00361-x","DOIUrl":"https://doi.org/10.1038/d41586-026-00361-x","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"280 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1038/s41586-025-10085-z
Dahlia R. Klein, Uri Zondiner, Amit Keren, John Birkbeck, Alon Inbar, Jiewen Xiao, Yuval Zamir, Mariia Sidorova, Mohammed M. Al Ezzi, Liangtao Peng, Kenji Watanabe, Takashi Taniguchi, Shaffique Adam, Shahal Ilani
{"title":"Imaging the sub-moiré potential using an atomic single electron transistor","authors":"Dahlia R. Klein, Uri Zondiner, Amit Keren, John Birkbeck, Alon Inbar, Jiewen Xiao, Yuval Zamir, Mariia Sidorova, Mohammed M. Al Ezzi, Liangtao Peng, Kenji Watanabe, Takashi Taniguchi, Shaffique Adam, Shahal Ilani","doi":"10.1038/s41586-025-10085-z","DOIUrl":"https://doi.org/10.1038/s41586-025-10085-z","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"9 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1038/s41586-025-10087-x
Xueqing Zoe Zou, Fengyuan Hu, Haiyi Lou, Oliver S. Burren, Xiaoyin Li, Karyn Megy, Eleanor Wheeler, Qiang Wu, Santosh S. Atanur, Marcin Karpinski, Douglas Loesch, Zammy Fairhurst-Hunter, Sri V. V. Deevi, Erin Oerton, Sean Wen, Xiao Jiang, Cecilia Salvoro, Jonathan Mitchell, Abhishek Nag, Ben Hollis, Amanda O’Neill, , Lauren Anderson-Dring, Mohammad Bohlooly-Y, Lisa Buvall, Sophia Cameron-Christie, Bram Prins, Suzanne Cohen, Regina F. Danielson, Andrew Davis, Wei Ding, Brian Dougherty, Manik Garg, Benjamin Georgi, Andrew Harper, Carolina Haefliger, Mårten Hammar, Richard N. Hanna, Ian Henry, Kousik Kundu, Zhongwu Lai, Mark Lal, Glenda Lassi, Yupu Liang, Margarida Lopes, Kieren Lythgow, Meeta Maisuria-Armer, Ruth March, Dorota Matelska, Rob Menzies, Erik Michaëlsson, Bill Mowrey, Daniel Muthas, Yoichiro Ohne, Benjamin Pullman, Sonja Hess, Arwa Raies, Anna Reznichenko, Xavier Romero Ros, Helen Stevens, Ioanna Tachmazidou, Coralie Viollet, Anna Walentinsson, Lily Wang, Qing-Dong Wang, Anna Cuomo, Daniel Elias Martin Herranz, Jared O’Connell, Jorge L. Del-Aguila, Anish Konkar, Benjamin Challis, Adam Platt, Tatiana Ort, James Garnett, Xiao-Rong Peng, Gabrielle Baumberg, Natalia Frydrych, Luca Stefanucci, Anna Szymaniak, Anna Maria Tsakiroglou, Rahul Sharma, Jen Harrow, Stewart MacArthur, Sebastian Wasilewski, Sean O’Dell, Lifeng Tian, Katherine R. Smith, Guillermo del Angel, Margarete Fabre, Ryan S. Dhindsa, Quanli Wang, Slavé Petrovski, Keren Carss
{"title":"Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes","authors":"Xueqing Zoe Zou, Fengyuan Hu, Haiyi Lou, Oliver S. Burren, Xiaoyin Li, Karyn Megy, Eleanor Wheeler, Qiang Wu, Santosh S. Atanur, Marcin Karpinski, Douglas Loesch, Zammy Fairhurst-Hunter, Sri V. V. Deevi, Erin Oerton, Sean Wen, Xiao Jiang, Cecilia Salvoro, Jonathan Mitchell, Abhishek Nag, Ben Hollis, Amanda O’Neill, , Lauren Anderson-Dring, Mohammad Bohlooly-Y, Lisa Buvall, Sophia Cameron-Christie, Bram Prins, Suzanne Cohen, Regina F. Danielson, Andrew Davis, Wei Ding, Brian Dougherty, Manik Garg, Benjamin Georgi, Andrew Harper, Carolina Haefliger, Mårten Hammar, Richard N. Hanna, Ian Henry, Kousik Kundu, Zhongwu Lai, Mark Lal, Glenda Lassi, Yupu Liang, Margarida Lopes, Kieren Lythgow, Meeta Maisuria-Armer, Ruth March, Dorota Matelska, Rob Menzies, Erik Michaëlsson, Bill Mowrey, Daniel Muthas, Yoichiro Ohne, Benjamin Pullman, Sonja Hess, Arwa Raies, Anna Reznichenko, Xavier Romero Ros, Helen Stevens, Ioanna Tachmazidou, Coralie Viollet, Anna Walentinsson, Lily Wang, Qing-Dong Wang, Anna Cuomo, Daniel Elias Martin Herranz, Jared O’Connell, Jorge L. Del-Aguila, Anish Konkar, Benjamin Challis, Adam Platt, Tatiana Ort, James Garnett, Xiao-Rong Peng, Gabrielle Baumberg, Natalia Frydrych, Luca Stefanucci, Anna Szymaniak, Anna Maria Tsakiroglou, Rahul Sharma, Jen Harrow, Stewart MacArthur, Sebastian Wasilewski, Sean O’Dell, Lifeng Tian, Katherine R. Smith, Guillermo del Angel, Margarete Fabre, Ryan S. Dhindsa, Quanli Wang, Slavé Petrovski, Keren Carss","doi":"10.1038/s41586-025-10087-x","DOIUrl":"https://doi.org/10.1038/s41586-025-10087-x","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"31 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1038/d41586-026-00358-6
Rachel Fieldhouse
{"title":"Innovative CAR-T therapy destroys cancer cells without dangerous side effects","authors":"Rachel Fieldhouse","doi":"10.1038/d41586-026-00358-6","DOIUrl":"https://doi.org/10.1038/d41586-026-00358-6","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"31 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1038/d41586-026-00338-w
Edward Chen
{"title":"How tumours trick the brain into shutting down cancer-fighting cells","authors":"Edward Chen","doi":"10.1038/d41586-026-00338-w","DOIUrl":"https://doi.org/10.1038/d41586-026-00338-w","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"58 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-04DOI: 10.1038/s41586-025-10073-3
Rongqin Li, Niko Dalheimer, Martin B. D. Müller, F. Ulrich Hartl
The essential chaperonin T-complex protein ring complex (TRiC) (also known as chaperonin containing TCP-1 (CCT)) mediates protein folding in cooperation with the co-chaperone prefoldin (PFD) 1–5 . In vitro experiments have shown that the cylindrical TRiC complex facilitates folding through ATP-regulated client protein encapsulation 6–9 . However, the functional dynamics of the chaperonin system in vivo remain unexplored. Here we developed single-particle tracking in human cells to monitor the interactions of TRiC–PFD with newly synthesized proteins. Both chaperones engaged nascent polypeptides repeatedly in brief probing events typically lasting around one second, with PFD recruiting TRiC. As shown with the chaperonin client actin 8 , the co-translational interactions of PFD and TRiC increased in frequency and lifetime during chain elongation. Close to translation termination, PFD bound for several seconds, facilitating TRiC recruitment for post-translational folding involving multiple reaction cycles of around 2.5 s. Notably, the lifetimes of TRiC interactions with a folding-defective actin mutant were markedly prolonged, indicating that client conformational properties modulate TRiC function. Mutant actin continued cycling on TRiC until it was targeted for degradation. TRiC often remained confined near its client protein between successive binding cycles, suggesting that the chaperonin machinery operates within a localized ‘protective zone’ in which free diffusion is restricted. Together, these findings offer detailed insight into the single-molecule dynamics and supramolecular organization of the chaperonin system in the cellular environment.
{"title":"Single-molecule dynamics of the TRiC chaperonin system in vivo","authors":"Rongqin Li, Niko Dalheimer, Martin B. D. Müller, F. Ulrich Hartl","doi":"10.1038/s41586-025-10073-3","DOIUrl":"https://doi.org/10.1038/s41586-025-10073-3","url":null,"abstract":"The essential chaperonin T-complex protein ring complex (TRiC) (also known as chaperonin containing TCP-1 (CCT)) mediates protein folding in cooperation with the co-chaperone prefoldin (PFD) <jats:sup>1–5</jats:sup> . In vitro experiments have shown that the cylindrical TRiC complex facilitates folding through ATP-regulated client protein encapsulation <jats:sup>6–9</jats:sup> . However, the functional dynamics of the chaperonin system in vivo remain unexplored. Here we developed single-particle tracking in human cells to monitor the interactions of TRiC–PFD with newly synthesized proteins. Both chaperones engaged nascent polypeptides repeatedly in brief probing events typically lasting around one second, with PFD recruiting TRiC. As shown with the chaperonin client actin <jats:sup>8</jats:sup> , the co-translational interactions of PFD and TRiC increased in frequency and lifetime during chain elongation. Close to translation termination, PFD bound for several seconds, facilitating TRiC recruitment for post-translational folding involving multiple reaction cycles of around 2.5 s. Notably, the lifetimes of TRiC interactions with a folding-defective actin mutant were markedly prolonged, indicating that client conformational properties modulate TRiC function. Mutant actin continued cycling on TRiC until it was targeted for degradation. TRiC often remained confined near its client protein between successive binding cycles, suggesting that the chaperonin machinery operates within a localized ‘protective zone’ in which free diffusion is restricted. Together, these findings offer detailed insight into the single-molecule dynamics and supramolecular organization of the chaperonin system in the cellular environment.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"30 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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