Pub Date : 2026-03-25DOI: 10.1038/s41586-026-10270-8
Alisha S. Kardian, Hua Sun, Siri Ippagunta, Nicholas Laboe, Srinidhi Varadharajan, Kwanha Yu, Hsiao-Chi Chen, Erik Emanus, Tuyu Zheng, Riley M. Deneen, Jon P. Connelly, Yong-Dong Wang, Jiangshan Zhan, Hengxi Liu, Kimberley Lowe, Taylor Bugbee, Rakesh Pathak, Amanda Bland, Sanya Mehta, Sophie Cochiolo, Amir Arabzade, Blake Holcomb, Kaitlin M. Budd, Gabriele Kembuan, Tristen Wright, Emma Caesar, Maxwell Park, Amelia Hancock, David Gee, Joel Murdoch, Yi Xiao, Samuel K. McBrayer, Thomas E. Merchant, Jun Qi, Adam D. Durbin, Lindsay A. Schwarz, Li Wang, Andrew M. Donson, Nicholas K. Foreman, Sameer Agnihotri, Alfonso Lavado, Suzanne J. Baker, David W. Ellison, Hyun Kyoung Lee, Shondra M. Pruett-Miller, Kelsey C. Bertrand, Benjamin Deneen, Stephen C. Mack
ZFTA–RELA is the most recurrent genetic alteration seen in paediatric supratentorial ependymoma (EPN) and is sufficient to initiate tumours in mice1. Despite its oncogenic potential, ZFTA–RELA (ZR) is observed nearly exclusively in childhood EPN, with tumours located distinctly in the supratentorial brain of the central nervous system1. We proposed that specific chromatin modules accessible during brain development would render distinct cell lineage programs at direct risk of transformation by ZR. To test this hypothesis, we performed combined single-nucleus assay for transposase-accessible chromatin and RNA (snMultiome) sequencing of the developing mouse forebrain compared with ZR-driven mouse and human EPN. We demonstrated that specific developmental lineage programs present in transient progenitor cells and regulated by PLAG/L family transcription factors were at risk of neoplastic transformation. Binding of this chromatin network by ZR or other PLAG/L family motifs targeting fusion oncoproteins led to persistent chromatin accessibility at oncogenic loci and oncogene expression. Cross-species analysis of mouse and human ZR EPN revealed significant cell type heterogeneity indicating incomplete neurogenic and gliogenic differentiation, with a small percentage of cycling progenitor-like or radial glial-like cells that established a putative tumour cell hierarchy. In vivo lineage tracing studies identified neoplastic clones that aggressively dominated tumour growth and established the entire EPN cellular hierarchy. These findings identify developmental epigenomic states that are critical for fusion-oncoprotein-driven transformation and show how these states continue to shape tumour progression.
{"title":"Dominant clones leverage developmental epigenomic states to drive ependymoma","authors":"Alisha S. Kardian, Hua Sun, Siri Ippagunta, Nicholas Laboe, Srinidhi Varadharajan, Kwanha Yu, Hsiao-Chi Chen, Erik Emanus, Tuyu Zheng, Riley M. Deneen, Jon P. Connelly, Yong-Dong Wang, Jiangshan Zhan, Hengxi Liu, Kimberley Lowe, Taylor Bugbee, Rakesh Pathak, Amanda Bland, Sanya Mehta, Sophie Cochiolo, Amir Arabzade, Blake Holcomb, Kaitlin M. Budd, Gabriele Kembuan, Tristen Wright, Emma Caesar, Maxwell Park, Amelia Hancock, David Gee, Joel Murdoch, Yi Xiao, Samuel K. McBrayer, Thomas E. Merchant, Jun Qi, Adam D. Durbin, Lindsay A. Schwarz, Li Wang, Andrew M. Donson, Nicholas K. Foreman, Sameer Agnihotri, Alfonso Lavado, Suzanne J. Baker, David W. Ellison, Hyun Kyoung Lee, Shondra M. Pruett-Miller, Kelsey C. Bertrand, Benjamin Deneen, Stephen C. Mack","doi":"10.1038/s41586-026-10270-8","DOIUrl":"https://doi.org/10.1038/s41586-026-10270-8","url":null,"abstract":"ZFTA–RELA is the most recurrent genetic alteration seen in paediatric supratentorial ependymoma (EPN) and is sufficient to initiate tumours in mice1. Despite its oncogenic potential, ZFTA–RELA (ZR) is observed nearly exclusively in childhood EPN, with tumours located distinctly in the supratentorial brain of the central nervous system1. We proposed that specific chromatin modules accessible during brain development would render distinct cell lineage programs at direct risk of transformation by ZR. To test this hypothesis, we performed combined single-nucleus assay for transposase-accessible chromatin and RNA (snMultiome) sequencing of the developing mouse forebrain compared with ZR-driven mouse and human EPN. We demonstrated that specific developmental lineage programs present in transient progenitor cells and regulated by PLAG/L family transcription factors were at risk of neoplastic transformation. Binding of this chromatin network by ZR or other PLAG/L family motifs targeting fusion oncoproteins led to persistent chromatin accessibility at oncogenic loci and oncogene expression. Cross-species analysis of mouse and human ZR EPN revealed significant cell type heterogeneity indicating incomplete neurogenic and gliogenic differentiation, with a small percentage of cycling progenitor-like or radial glial-like cells that established a putative tumour cell hierarchy. In vivo lineage tracing studies identified neoplastic clones that aggressively dominated tumour growth and established the entire EPN cellular hierarchy. These findings identify developmental epigenomic states that are critical for fusion-oncoprotein-driven transformation and show how these states continue to shape tumour progression.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"16 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1038/d41586-026-00893-2
Elizabeth Gibney
{"title":"Major conference catches illicit AI use — and rejects hundreds of papers","authors":"Elizabeth Gibney","doi":"10.1038/d41586-026-00893-2","DOIUrl":"https://doi.org/10.1038/d41586-026-00893-2","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"23 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1038/s41586-026-10170-x
William A. Marsh, Lachie Scarsbrook, Eren Yüncü, Lizzie Hodgson, Audrey T. Lin, Maria De Iorio, Olaf Thalmann, Mark G. Thomas, Mahaut Goor, Anders Bergström, Angela Noseda, Sarieh Amiri, Fereidoun Biglari, Dušan Borić, Katia Bougiouri, Alberto Carmagnini, Maddalena Giannì, Tom Higham, Ophelie Lebrasseur, Anna Linderholm, Marcello A. Mannino, Caroline Middleton, Gökhan Mustafaoğlu, Angela Perri, Joris Peters, Mike Richards, Özlem Sarıtaş, Pontus Skoglund, Rhiannon E. Stevens, Chris Stringer, Kristina Tabbada, Helen M. Talbot, Laura G. Van der Sluis, Silvia M. Bello, Vesna Dimitrijevic, Louise Martin, Marjan Mashkour, Simon A. Parfitt, Sonja Vukovic, Selina Brace, Oliver E. Craig, Douglas Baird, Sophy Charlton, Greger Larson, Ian Barnes, Laurent A. F. Frantz
Archaeological evidence suggests that dogs diverged from wolves during the Palaeolithic, more than 15,000 years ago1,2,3,4,5,6,7. The earliest unequivocal genetic evidence, however, is associated with dog remains from Mesolithic archaeological contexts approximately 10,900 years ago8,9. Here we generate both nuclear and mitochondrial genomes from canid remains at Pınarbaşı in Türkiye (15,800 years ago)10 and Gough’s Cave in the UK (14,300 years ago)11, as well as from dogs excavated from two Mesolithic sites in Serbia (Padina between 11,500–7,900 years ago and Vlasac 8,900 years ago)12,13. Our analyses indicate that a genetically homogeneous dog population was already widely distributed across Europe and Anatolia during the Late Upper Palaeolithic (by at least 14,300 years ago). This finding suggests that dogs were exchanged among genetically and culturally distinct western Eurasian Late Palaeolithic human populations, namely the Magdalenian, Epigravettian and Anatolian hunter-gatherers10,14,15,16. Last, we identify a major influx of eastern Eurasian dog ancestry during the Mesolithic, concomitant with the movement of eastern hunter-gatherer populations into Europe14, which led to the establishment of the primary ancestry characteristics that define European dog populations today.
{"title":"Dogs were widely distributed across western Eurasia during the Palaeolithic","authors":"William A. Marsh, Lachie Scarsbrook, Eren Yüncü, Lizzie Hodgson, Audrey T. Lin, Maria De Iorio, Olaf Thalmann, Mark G. Thomas, Mahaut Goor, Anders Bergström, Angela Noseda, Sarieh Amiri, Fereidoun Biglari, Dušan Borić, Katia Bougiouri, Alberto Carmagnini, Maddalena Giannì, Tom Higham, Ophelie Lebrasseur, Anna Linderholm, Marcello A. Mannino, Caroline Middleton, Gökhan Mustafaoğlu, Angela Perri, Joris Peters, Mike Richards, Özlem Sarıtaş, Pontus Skoglund, Rhiannon E. Stevens, Chris Stringer, Kristina Tabbada, Helen M. Talbot, Laura G. Van der Sluis, Silvia M. Bello, Vesna Dimitrijevic, Louise Martin, Marjan Mashkour, Simon A. Parfitt, Sonja Vukovic, Selina Brace, Oliver E. Craig, Douglas Baird, Sophy Charlton, Greger Larson, Ian Barnes, Laurent A. F. Frantz","doi":"10.1038/s41586-026-10170-x","DOIUrl":"https://doi.org/10.1038/s41586-026-10170-x","url":null,"abstract":"Archaeological evidence suggests that dogs diverged from wolves during the Palaeolithic, more than 15,000 years ago1,2,3,4,5,6,7. The earliest unequivocal genetic evidence, however, is associated with dog remains from Mesolithic archaeological contexts approximately 10,900 years ago8,9. Here we generate both nuclear and mitochondrial genomes from canid remains at Pınarbaşı in Türkiye (15,800 years ago)10 and Gough’s Cave in the UK (14,300 years ago)11, as well as from dogs excavated from two Mesolithic sites in Serbia (Padina between 11,500–7,900 years ago and Vlasac 8,900 years ago)12,13. Our analyses indicate that a genetically homogeneous dog population was already widely distributed across Europe and Anatolia during the Late Upper Palaeolithic (by at least 14,300 years ago). This finding suggests that dogs were exchanged among genetically and culturally distinct western Eurasian Late Palaeolithic human populations, namely the Magdalenian, Epigravettian and Anatolian hunter-gatherers10,14,15,16. Last, we identify a major influx of eastern Eurasian dog ancestry during the Mesolithic, concomitant with the movement of eastern hunter-gatherer populations into Europe14, which led to the establishment of the primary ancestry characteristics that define European dog populations today.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"17 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1038/s41586-026-10219-x
Hoyt Patrick Taylor IV, Khoi Minh Huynh, Kim-Han Thung, Guoye Lin, Wenjiao Lyu, Weili Lin, Sahar Ahmad, Pew-Thian Yap
Large-scale gradients of functional connectivity between brain areas organize the human neocortex, linking brain topography to the texture of cognition1,2. In adults, three dominant axes—sensory–association, visual–somatosensory and modulation–representation—run, respectively, from primary sensory to transmodal association areas, from visual to body-centred systems and from control and attention networks to default mode and sensory areas1,2,3,4. These gradients provide a compact description of large-scale cortical hierarchies that underlie distinct modes of information processing. However, how these gradients and their multiscale biological and cognitive correlates evolve across the lifespan is unknown. Here we establish a continuous normative reference of functional organization from birth to 100 years of age, revealing complex, nonlinear developmental trajectories. Gradient architecture is anchored by primary sensory systems in infancy, differentiates along association and control axes during childhood and adolescence and gradually dedifferentiates during ageing. The importance of this functional architecture is corroborated by biology and behaviour: gradient metrics predict cognitive performance across development; structure–function coupling varies by axis and age; and distinct transcriptomic signatures are strongest early in life and weaken with age, consistent with a transient genetic scaffold for gradient architecture. Our lifespan gradients unify diverse research into developmental brain connectivity and provide a shared multimodal reference for future studies.
{"title":"Functional hierarchy of the human neocortex across the lifespan","authors":"Hoyt Patrick Taylor IV, Khoi Minh Huynh, Kim-Han Thung, Guoye Lin, Wenjiao Lyu, Weili Lin, Sahar Ahmad, Pew-Thian Yap","doi":"10.1038/s41586-026-10219-x","DOIUrl":"https://doi.org/10.1038/s41586-026-10219-x","url":null,"abstract":"Large-scale gradients of functional connectivity between brain areas organize the human neocortex, linking brain topography to the texture of cognition1,2. In adults, three dominant axes—sensory–association, visual–somatosensory and modulation–representation—run, respectively, from primary sensory to transmodal association areas, from visual to body-centred systems and from control and attention networks to default mode and sensory areas1,2,3,4. These gradients provide a compact description of large-scale cortical hierarchies that underlie distinct modes of information processing. However, how these gradients and their multiscale biological and cognitive correlates evolve across the lifespan is unknown. Here we establish a continuous normative reference of functional organization from birth to 100 years of age, revealing complex, nonlinear developmental trajectories. Gradient architecture is anchored by primary sensory systems in infancy, differentiates along association and control axes during childhood and adolescence and gradually dedifferentiates during ageing. The importance of this functional architecture is corroborated by biology and behaviour: gradient metrics predict cognitive performance across development; structure–function coupling varies by axis and age; and distinct transcriptomic signatures are strongest early in life and weaken with age, consistent with a transient genetic scaffold for gradient architecture. Our lifespan gradients unify diverse research into developmental brain connectivity and provide a shared multimodal reference for future studies.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"49 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rice is a staple crop for more than half of the world’s population, and its sustainable production is vital to ensure global food security. However, rice is susceptible to several devastating fungal diseases1, including blast disease caused by Magnaporthe oryzae, sheath blight by Rhizoctonia solani, false smut by Ustilaginoidea virens, brown spot by Bipolaris oryzae, bakanae by Fusarium fujikuroi and head blight by Fusarium graminearum. The mechanisms underlying the susceptibility to these fungal diseases remain unclear. Here we report that the β subunit of SnRK1, SnRK1β1A, confers broad-spectrum susceptibility to these fungal diseases. Our findings show that diverse rice fungal pathogens have convergently evolved an effector-like protein, Gas2, which interacts with SnRK1β1A to prevent its ubiquitination-mediated degradation and promotes its nuclear translocation. SnRK1β1A is markedly induced on fungal infection, promoting susceptibility by inhibiting SnRK1α1, an α subunit of SnRK1 known to positively regulate broad-spectrum resistance in rice2. Notably, rice lines with disrupted SnRK1β1A are resistant to several fungal diseases without compromising growth and yield in the field under normal farming conditions. This study demonstrates that broad-spectrum disease resistance in crops can be achieved by disrupting inducible susceptibility genes whose encoded proteins are targeted by effectors conserved across several pathogens.
{"title":"Inactivating SnRK1β1A promotes broad-spectrum disease resistance in rice","authors":"Guixin Yuan, Xunli Lu, Xingbin Wang, Mengfei Li, Shiwei Wang, Zhaoxiang Huang, Zhigang Li, Fengrui Zhang, Xin Zhang, Jun Yang, Hailong Guo, Vijai Bhadauria, Wang-Sheng Zhu, Wensheng Zhao, Meng Yuan, Jian-Min Zhou, You-Liang Peng","doi":"10.1038/s41586-026-10273-5","DOIUrl":"https://doi.org/10.1038/s41586-026-10273-5","url":null,"abstract":"Rice is a staple crop for more than half of the world’s population, and its sustainable production is vital to ensure global food security. However, rice is susceptible to several devastating fungal diseases1, including blast disease caused by Magnaporthe oryzae, sheath blight by Rhizoctonia solani, false smut by Ustilaginoidea virens, brown spot by Bipolaris oryzae, bakanae by Fusarium fujikuroi and head blight by Fusarium graminearum. The mechanisms underlying the susceptibility to these fungal diseases remain unclear. Here we report that the β subunit of SnRK1, SnRK1β1A, confers broad-spectrum susceptibility to these fungal diseases. Our findings show that diverse rice fungal pathogens have convergently evolved an effector-like protein, Gas2, which interacts with SnRK1β1A to prevent its ubiquitination-mediated degradation and promotes its nuclear translocation. SnRK1β1A is markedly induced on fungal infection, promoting susceptibility by inhibiting SnRK1α1, an α subunit of SnRK1 known to positively regulate broad-spectrum resistance in rice2. Notably, rice lines with disrupted SnRK1β1A are resistant to several fungal diseases without compromising growth and yield in the field under normal farming conditions. This study demonstrates that broad-spectrum disease resistance in crops can be achieved by disrupting inducible susceptibility genes whose encoded proteins are targeted by effectors conserved across several pathogens.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"45 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1038/s41586-026-10306-z
Raquel Francés, Typhaine Comyn, Coraline Desnous, Francesca Bettoni, Alice Pavlowsky, Thomas Preat, Pierre-Yves Plaçais
The formation of food-related memories involves post-ingestion nutrient sensing signals1,2,3,4,5. Whether nutrient sensors act beyond feeding-relevant behaviour is less well understood. Here we show that an internal sugar sensor in the Drosophila brain6 is involved in memory consolidation, both in fasted flies subjected to an appetitive learning task involving a sucrose reward and in flies fed ad libitum subjected to an aversive learning task independent of food cues7,8. In the latter, spaced repetition of learning sessions, a prerequisite to induce long-term memory, lures brain fructose-sensing neurons into a fasted state through a disinhibition mechanism that transiently restores their sensing ability despite satiation9. Post-learning sugar ingestion activates disinhibited fructose-sensing neurons, which triggers memory consolidation through the release of the glycoprotein hormone thyrostimulin10,11, as in appetitive learning. The reset of fructose-sensing neurons by spaced training also results in a fasted state-like feeding behaviour, manifesting in a strong increase in sucrose preference and intake. By revealing a mechanism of non-homeostatic hunger and its critical relevance for memory consolidation, our results provide a neural circuit basis, and a cognitive value, to a behaviour akin to emotional eating.
{"title":"Aversive learning hijacks a brain sugar sensor to consolidate memory","authors":"Raquel Francés, Typhaine Comyn, Coraline Desnous, Francesca Bettoni, Alice Pavlowsky, Thomas Preat, Pierre-Yves Plaçais","doi":"10.1038/s41586-026-10306-z","DOIUrl":"https://doi.org/10.1038/s41586-026-10306-z","url":null,"abstract":"The formation of food-related memories involves post-ingestion nutrient sensing signals1,2,3,4,5. Whether nutrient sensors act beyond feeding-relevant behaviour is less well understood. Here we show that an internal sugar sensor in the Drosophila brain6 is involved in memory consolidation, both in fasted flies subjected to an appetitive learning task involving a sucrose reward and in flies fed ad libitum subjected to an aversive learning task independent of food cues7,8. In the latter, spaced repetition of learning sessions, a prerequisite to induce long-term memory, lures brain fructose-sensing neurons into a fasted state through a disinhibition mechanism that transiently restores their sensing ability despite satiation9. Post-learning sugar ingestion activates disinhibited fructose-sensing neurons, which triggers memory consolidation through the release of the glycoprotein hormone thyrostimulin10,11, as in appetitive learning. The reset of fructose-sensing neurons by spaced training also results in a fasted state-like feeding behaviour, manifesting in a strong increase in sucrose preference and intake. By revealing a mechanism of non-homeostatic hunger and its critical relevance for memory consolidation, our results provide a neural circuit basis, and a cognitive value, to a behaviour akin to emotional eating.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"52 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1038/d41586-026-00638-1
Najla Kfoury-Beaumont
{"title":"Testosterone promotes growth of a type of brain tumour in young boys.","authors":"Najla Kfoury-Beaumont","doi":"10.1038/d41586-026-00638-1","DOIUrl":"https://doi.org/10.1038/d41586-026-00638-1","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":48.5,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1038/d41586-026-00637-2
Richard A I Bethlehem, Daniel S Margulies
{"title":"Charting the human brain's lifelong functional organization.","authors":"Richard A I Bethlehem, Daniel S Margulies","doi":"10.1038/d41586-026-00637-2","DOIUrl":"https://doi.org/10.1038/d41586-026-00637-2","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":48.5,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1038/d41586-026-00423-0
Simon Baker
{"title":"Can China keep up its extraordinary research growth?","authors":"Simon Baker","doi":"10.1038/d41586-026-00423-0","DOIUrl":"https://doi.org/10.1038/d41586-026-00423-0","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"19 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-25DOI: 10.1038/d41586-026-00933-x
Michael Paul Nelson
{"title":"‘Continuity over novelty’: why environmental science needs to rethink its focus","authors":"Michael Paul Nelson","doi":"10.1038/d41586-026-00933-x","DOIUrl":"https://doi.org/10.1038/d41586-026-00933-x","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"22 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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