Pub Date : 2024-11-18DOI: 10.1038/s41579-024-01131-0
Andrea Du Toit
This study provides insights into how adaptive changes in evolved microbial communities can affect pathogen invasion.
这项研究让人们深入了解了微生物群落进化过程中的适应性变化如何影响病原体入侵。
{"title":"Waning resistance","authors":"Andrea Du Toit","doi":"10.1038/s41579-024-01131-0","DOIUrl":"https://doi.org/10.1038/s41579-024-01131-0","url":null,"abstract":"This study provides insights into how adaptive changes in evolved microbial communities can affect pathogen invasion.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"12 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1038/s41579-024-01130-1
Agustina Taglialegna
In this study, Tofani et al. demonstrate that the gut microbiota regulates stress responsiveness in mice via the circadian system.
在这项研究中，Tofani 等人证明肠道微生物群通过昼夜节律系统调节小鼠的应激反应能力。
{"title":"Gut microbiota clocks in stress","authors":"Agustina Taglialegna","doi":"10.1038/s41579-024-01130-1","DOIUrl":"https://doi.org/10.1038/s41579-024-01130-1","url":null,"abstract":"In this study, Tofani et al. demonstrate that the gut microbiota regulates stress responsiveness in mice via the circadian system.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"20 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-18DOI: 10.1038/s41579-024-01124-z
Rachel T. Giorgio, Sophie Helaine
Antibiotic-recalcitrant infections, defined as the prolonged carriage of pathogenic bacteria even in the presence of antibiotics, are often caused by bacteria that are genetically susceptible to the drug. These recalcitrant bacteria fail to proliferate in the presence of antibiotics but remain viable such that they may recolonize their niche following antibiotic withdrawal. Significant progress has been made in our understanding of antibiotic-recalcitrant Salmonella, which are thought to be the source of infection relapse. In recent years, it has been shown that recalcitrant bacteria manipulate host immune defences and could directly contribute to the spread of antimicrobial resistance. In this Review, we provide an overview of what is currently known about the antibiotic recalcitrance of Salmonella during infection and highlight knowledge gaps requiring additional research in the future.
{"title":"Antibiotic-recalcitrant Salmonella during infection","authors":"Rachel T. Giorgio, Sophie Helaine","doi":"10.1038/s41579-024-01124-z","DOIUrl":"https://doi.org/10.1038/s41579-024-01124-z","url":null,"abstract":"<p>Antibiotic-recalcitrant infections, defined as the prolonged carriage of pathogenic bacteria even in the presence of antibiotics, are often caused by bacteria that are genetically susceptible to the drug. These recalcitrant bacteria fail to proliferate in the presence of antibiotics but remain viable such that they may recolonize their niche following antibiotic withdrawal. Significant progress has been made in our understanding of antibiotic-recalcitrant <i>Salmonella</i>, which are thought to be the source of infection relapse. In recent years, it has been shown that recalcitrant bacteria manipulate host immune defences and could directly contribute to the spread of antimicrobial resistance. In this Review, we provide an overview of what is currently known about the antibiotic recalcitrance of <i>Salmonella</i> during infection and highlight knowledge gaps requiring additional research in the future.</p>","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"168 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-14DOI: 10.1038/s41579-024-01101-6
Nazneen Damji, Lillian Mworeko
{"title":"Gender justice and prioritizing women and girls in the HIV response.","authors":"Nazneen Damji, Lillian Mworeko","doi":"10.1038/s41579-024-01101-6","DOIUrl":"https://doi.org/10.1038/s41579-024-01101-6","url":null,"abstract":"","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":" ","pages":""},"PeriodicalIF":69.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-14DOI: 10.1038/s41579-024-01127-w
Onalenna Neo, Nisha Singh, Adrian Cazares
{"title":"A river of resistant genes uncovered by metagenomics.","authors":"Onalenna Neo, Nisha Singh, Adrian Cazares","doi":"10.1038/s41579-024-01127-w","DOIUrl":"10.1038/s41579-024-01127-w","url":null,"abstract":"","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":" ","pages":""},"PeriodicalIF":69.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-08DOI: 10.1038/s41579-023-00992-1
Andrea Du Toit
This study reports the identification of an archaeal virus Acr protein that blocks the dissociation of the target RNA from the type III-B CRISPR–Cas effector complex, which prevents the recycling of the complex.
{"title":"Sabotage of CRISPR–Cas","authors":"Andrea Du Toit","doi":"10.1038/s41579-023-00992-1","DOIUrl":"10.1038/s41579-023-00992-1","url":null,"abstract":"This study reports the identification of an archaeal virus Acr protein that blocks the dissociation of the target RNA from the type III-B CRISPR–Cas effector complex, which prevents the recycling of the complex.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 1","pages":"1-1"},"PeriodicalIF":88.1,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-06DOI: 10.1038/s41579-023-00991-2
Robert F. J. Kullberg, Timothy J. Rozday, Bastiaan W. Haak
This month’s Genome Watch highlights how a tailor-made search through bacterial genomes revealed the widespread presence of a new class of bacterial signalling peptides that lack conventional characteristics. This Genome Watch highlights how a tailor-made search through bacterial genomes revealed the widespread presence of a new class of bacterial signalling peptides that lack conventional characteristics.
{"title":"Microbial murmurs — decoding hidden conversations between bacteria","authors":"Robert F. J. Kullberg, Timothy J. Rozday, Bastiaan W. Haak","doi":"10.1038/s41579-023-00991-2","DOIUrl":"10.1038/s41579-023-00991-2","url":null,"abstract":"This month’s Genome Watch highlights how a tailor-made search through bacterial genomes revealed the widespread presence of a new class of bacterial signalling peptides that lack conventional characteristics. This Genome Watch highlights how a tailor-made search through bacterial genomes revealed the widespread presence of a new class of bacterial signalling peptides that lack conventional characteristics.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 1","pages":"3-3"},"PeriodicalIF":88.1,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71483821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-24DOI: 10.1038/s41579-023-00989-w
Andrea Du Toit
This study reports that intracellular cord formation by Mycobacterium tuberculosis is an important feature of early pathogenesis.
本研究报告指出，结核分枝杆菌在细胞内形成脐带是早期发病的一个重要特征。
{"title":"Mycobacterial cords","authors":"Andrea Du Toit","doi":"10.1038/s41579-023-00989-w","DOIUrl":"10.1038/s41579-023-00989-w","url":null,"abstract":"This study reports that intracellular cord formation by Mycobacterium tuberculosis is an important feature of early pathogenesis.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"21 12","pages":"769-769"},"PeriodicalIF":88.1,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-10-20DOI: 10.1038/s41579-023-00980-5
Laurent Philippot, Claire Chenu, Andreas Kappler, Matthias C. Rillig, Noah Fierer
In recent years, there has been considerable progress in determining the soil properties that influence the structure of the soil microbiome. By contrast, the effects of microorganisms on their soil habitat have received less attention with most previous studies focusing on microbial contributions to soil carbon and nitrogen dynamics. However, soil microorganisms are not only involved in nutrient cycling and organic matter transformations but also alter the soil habitat through various biochemical and biophysical mechanisms. Such microbially mediated modifications of soil properties can have local impacts on microbiome assembly with pronounced ecological ramifications. In this Review, we describe the processes by which microorganisms modify the soil environment, considering soil physics, hydrology and chemistry. We explore how microorganism–soil interactions can generate feedback loops and discuss how microbially mediated modifications of soil properties can serve as an alternative avenue for the management and manipulation of microbiomes to combat soil threats and global change. In this Review, Philippot et al. explore how soil microorganisms can affect the physical and chemical properties of soil and discuss the ecological and evolutionary consequences of these microbially driven shifts in soil properties. They also explore how microbially mediated changes in soil properties can be used to combat threats to soil health and other environmental challenges.
{"title":"The interplay between microbial communities and soil properties","authors":"Laurent Philippot, Claire Chenu, Andreas Kappler, Matthias C. Rillig, Noah Fierer","doi":"10.1038/s41579-023-00980-5","DOIUrl":"10.1038/s41579-023-00980-5","url":null,"abstract":"In recent years, there has been considerable progress in determining the soil properties that influence the structure of the soil microbiome. By contrast, the effects of microorganisms on their soil habitat have received less attention with most previous studies focusing on microbial contributions to soil carbon and nitrogen dynamics. However, soil microorganisms are not only involved in nutrient cycling and organic matter transformations but also alter the soil habitat through various biochemical and biophysical mechanisms. Such microbially mediated modifications of soil properties can have local impacts on microbiome assembly with pronounced ecological ramifications. In this Review, we describe the processes by which microorganisms modify the soil environment, considering soil physics, hydrology and chemistry. We explore how microorganism–soil interactions can generate feedback loops and discuss how microbially mediated modifications of soil properties can serve as an alternative avenue for the management and manipulation of microbiomes to combat soil threats and global change. In this Review, Philippot et al. explore how soil microorganisms can affect the physical and chemical properties of soil and discuss the ecological and evolutionary consequences of these microbially driven shifts in soil properties. They also explore how microbially mediated changes in soil properties can be used to combat threats to soil health and other environmental challenges.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"22 4","pages":"226-239"},"PeriodicalIF":88.1,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49679837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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