Pub Date : 2025-12-09DOI: 10.1038/s41579-025-01269-5
Andrea Du Toit
This study reports that the commensal gut bacterium Bacteroides thetaiotaomicron establishes distinct subpopulations in response to two secreted, self-targeting effector proteins.
{"title":"Splitting the population in the gut","authors":"Andrea Du Toit","doi":"10.1038/s41579-025-01269-5","DOIUrl":"10.1038/s41579-025-01269-5","url":null,"abstract":"This study reports that the commensal gut bacterium Bacteroides thetaiotaomicron establishes distinct subpopulations in response to two secreted, self-targeting effector proteins.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"24 2","pages":"93-93"},"PeriodicalIF":103.3,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1038/s41579-025-01267-7
Shimona Starling
This paper reports week 96 efficacy and safety findings from a multicentre, open-label phase IIIb trial of intramuscular cabotegravir and rilpivirine in adults living with HIV from Uganda, Kenya and South Africa.
{"title":"Long-acting therapy for HIV shows promise in African trial","authors":"Shimona Starling","doi":"10.1038/s41579-025-01267-7","DOIUrl":"10.1038/s41579-025-01267-7","url":null,"abstract":"This paper reports week 96 efficacy and safety findings from a multicentre, open-label phase IIIb trial of intramuscular cabotegravir and rilpivirine in adults living with HIV from Uganda, Kenya and South Africa.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"24 1","pages":"5-5"},"PeriodicalIF":103.3,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145554409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1038/s41579-025-01264-w
Hsueh-Chien Raymond Cheng, Diego Teixeira
This Genome Watch discusses recent advances in genomic epidemiology that enable the reconstruction of transmission events, with greater resolution and across more complex settings at scale.
{"title":"Unpacking the spread of pathogens","authors":"Hsueh-Chien Raymond Cheng, Diego Teixeira","doi":"10.1038/s41579-025-01264-w","DOIUrl":"10.1038/s41579-025-01264-w","url":null,"abstract":"This Genome Watch discusses recent advances in genomic epidemiology that enable the reconstruction of transmission events, with greater resolution and across more complex settings at scale.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"24 2","pages":"96-96"},"PeriodicalIF":103.3,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1038/s41579-025-01259-7
Arthur Kocher, Johannes Krause, Maria A. Spyrou
{"title":"Insights into infectious diseases through ancient pathogen genomics","authors":"Arthur Kocher, Johannes Krause, Maria A. Spyrou","doi":"10.1038/s41579-025-01259-7","DOIUrl":"https://doi.org/10.1038/s41579-025-01259-7","url":null,"abstract":"","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"28 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1038/s41579-025-01256-w
Jan C. Wohlfarth, Danny Ward, Joana Pereira, Marek Basler
{"title":"The type VI secretion system and associated effector proteins","authors":"Jan C. Wohlfarth, Danny Ward, Joana Pereira, Marek Basler","doi":"10.1038/s41579-025-01256-w","DOIUrl":"https://doi.org/10.1038/s41579-025-01256-w","url":null,"abstract":"","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"7 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145509079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1038/s41579-025-01262-y
Jessica A. Griffiths, Khemlal Nirmalkar, Wei-Li Wu, Rosa Krajmalnik-Brown, Sarkis K. Mazmanian
{"title":"The gut microbiome shapes social behaviour across animal species","authors":"Jessica A. Griffiths, Khemlal Nirmalkar, Wei-Li Wu, Rosa Krajmalnik-Brown, Sarkis K. Mazmanian","doi":"10.1038/s41579-025-01262-y","DOIUrl":"https://doi.org/10.1038/s41579-025-01262-y","url":null,"abstract":"","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"3 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145509118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-13DOI: 10.1038/s41579-025-01258-8
Buse Isbilir, Andriko von Kügelgen, Vikram Alva, Tanmay A. M. Bharat
{"title":"Assembly, architecture and functional roles of microbial surface layers","authors":"Buse Isbilir, Andriko von Kügelgen, Vikram Alva, Tanmay A. M. Bharat","doi":"10.1038/s41579-025-01258-8","DOIUrl":"https://doi.org/10.1038/s41579-025-01258-8","url":null,"abstract":"","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"173 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145498273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1038/s41579-025-01265-9
Shimona Starling
This study identifies multiple low-density lipoprotein receptor family members, including LRP4, LRP1 and VLDLR, as entry receptors for yellow fever virus.
{"title":"Unlocking entry for yellow fever virus","authors":"Shimona Starling","doi":"10.1038/s41579-025-01265-9","DOIUrl":"10.1038/s41579-025-01265-9","url":null,"abstract":"This study identifies multiple low-density lipoprotein receptor family members, including LRP4, LRP1 and VLDLR, as entry receptors for yellow fever virus.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"24 1","pages":"4-4"},"PeriodicalIF":103.3,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-10DOI: 10.1038/s41579-025-01254-y
Mary K. Hayden, Sarah E. Sansom, Evan S. Snitkin
{"title":"Genome sequencing for prevention of health-care-associated bacterial infections","authors":"Mary K. Hayden, Sarah E. Sansom, Evan S. Snitkin","doi":"10.1038/s41579-025-01254-y","DOIUrl":"https://doi.org/10.1038/s41579-025-01254-y","url":null,"abstract":"","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"47 1","pages":""},"PeriodicalIF":88.1,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145478043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-10DOI: 10.1038/s41579-025-01255-x
Ryuta Uraki, Bette Korber, Michael S. Diamond, Yoshihiro Kawaoka
More than 5 years have passed since the emergence of the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yet this virus continues to circulate globally, undergoing evolutionary changes. The effective control of SARS-CoV-2 necessitates an understanding of its antigenicity, replicative capacity, pathogenicity and transmissibility, as well as the development of preventive and treatment options. In this Review, we describe the origins and evolution of SARS-CoV-2, and outline variant and subvariant-specific characteristics. We also discuss the challenges faced in implementing prevention and treatment methods, such as the emergence of antigenically distinct variants and the phenomenon of immune imprinting. This Review provides insights into combating the ongoing COVID-19 pandemic and guidance for future research and vaccine development efforts. This Review explores the evolution of SARS-CoV-2 since its emergence in late 2019 and discusses how the changes in the various variants and subvariants have affected the viral life cycle and ongoing transmission. In addition, prevention and treatment strategies are outlined, as well as the effects of antigenically distinct variants and immune imprinting on immunity after natural infection or vaccination.
{"title":"SARS-CoV-2 variants: biology, pathogenicity, immunity and control","authors":"Ryuta Uraki, Bette Korber, Michael S. Diamond, Yoshihiro Kawaoka","doi":"10.1038/s41579-025-01255-x","DOIUrl":"10.1038/s41579-025-01255-x","url":null,"abstract":"More than 5 years have passed since the emergence of the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yet this virus continues to circulate globally, undergoing evolutionary changes. The effective control of SARS-CoV-2 necessitates an understanding of its antigenicity, replicative capacity, pathogenicity and transmissibility, as well as the development of preventive and treatment options. In this Review, we describe the origins and evolution of SARS-CoV-2, and outline variant and subvariant-specific characteristics. We also discuss the challenges faced in implementing prevention and treatment methods, such as the emergence of antigenically distinct variants and the phenomenon of immune imprinting. This Review provides insights into combating the ongoing COVID-19 pandemic and guidance for future research and vaccine development efforts. This Review explores the evolution of SARS-CoV-2 since its emergence in late 2019 and discusses how the changes in the various variants and subvariants have affected the viral life cycle and ongoing transmission. In addition, prevention and treatment strategies are outlined, as well as the effects of antigenically distinct variants and immune imprinting on immunity after natural infection or vaccination.","PeriodicalId":18838,"journal":{"name":"Nature Reviews Microbiology","volume":"24 1","pages":"8-28"},"PeriodicalIF":103.3,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145478176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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