Marrubium vulgare L. leaves have long been recognised in Moroccan traditional medicine for their effectiveness in managing pain and inflammation. However, their potential is in treating peripheral neuropathic pain. This study aimed to investigate the effects of M. vulgare aqueous extract (AEMV) on peripheral neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve in mice. This research represents the first exploration of AEMV’s therapeutic potential in neuropathic pain management. AEMV was initially analysed using HPLC MS/MS to identify its predominant compound, Marrubiin. Mice underwent CCI surgery to induce neuropathic pain. AEMV was administered orally and Clomipramine served as a positive control. Chronic administration of AEMV significantly attenuated thermal, mechanical, and cold sensitivity induced by CCI. It also promoted functional and histological recovery of the sciatic nerve.
长期以来，摩洛哥传统医学一直认为马鲁巴叶具有止痛和消炎的功效。然而，它们在治疗外周神经病理性疼痛方面也具有潜力。本研究旨在探讨 M. vulgare 水提取物（AEMV）对小鼠坐骨神经慢性收缩损伤（CCI）诱发的周围神经病理性疼痛的影响。这项研究首次探索了 AEMV 在治疗神经性疼痛方面的潜力。首先使用 HPLC MS/MS 对 AEMV 进行分析，以确定其主要化合物 Marrubiin。小鼠接受 CCI 手术，诱发神经病理性疼痛。口服 AEMV，氯米帕明作为阳性对照。长期服用 AEMV 能明显减轻 CCI 引起的热敏性、机械性和冷敏感性。它还能促进坐骨神经的功能和组织学恢复。
{"title":"Therapeutic effect of Marrubium vulgare L. Aqueous extract on chronic constriction injury of sciatic nerve-induced neuropathic pain in mice","authors":"Abdelfatah Aitbaba , Hamid Kabdy , Abdelmounaim Baslam , Hajar Azraida , Jawad Laadraoui , Karima Raoui , Rachida Aboufatima , Loubna El Yazouli , Zahra Sokar , Stefania Garzoli , Abderrahman Chait","doi":"10.1080/14786419.2024.2424403","DOIUrl":"10.1080/14786419.2024.2424403","url":null,"abstract":"<div><div><em>Marrubium vulgare</em> L. leaves have long been recognised in Moroccan traditional medicine for their effectiveness in managing pain and inflammation. However, their potential is in treating peripheral neuropathic pain. This study aimed to investigate the effects <em>of M. vulgare</em> aqueous extract (AEMV) on peripheral neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve in mice. This research represents the first exploration of AEMV’s therapeutic potential in neuropathic pain management. AEMV was initially analysed using HPLC MS/MS to identify its predominant compound, Marrubiin. Mice underwent CCI surgery to induce neuropathic pain. AEMV was administered orally and Clomipramine served as a positive control. Chronic administration of AEMV significantly attenuated thermal, mechanical, and cold sensitivity induced by CCI. It also promoted functional and histological recovery of the sciatic nerve.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 5","pages":"Pages 1318-1326"},"PeriodicalIF":1.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-04Epub Date: 2024-10-14DOI: 10.1080/14786419.2024.2417359
Vinothini Gunasekaran , Palanivel Sathishkumar
{"title":"Importance of natural products to overcome antimicrobial resistance: time to rethink","authors":"Vinothini Gunasekaran , Palanivel Sathishkumar","doi":"10.1080/14786419.2024.2417359","DOIUrl":"10.1080/14786419.2024.2417359","url":null,"abstract":"","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 5","pages":"Pages 1377-1378"},"PeriodicalIF":1.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-04DOI: 10.1080/14786419.2026.2640144
Anaïs Cyatwa, Joseph Thiery, Agathe Martinez, Alexis Kotland, Jane Hubert
Vegetable oils are increasingly used to formulate bioactive ingredients with pharmaceutical, nutraceutical or cosmeceutical applications. Their biological properties depend directly on their chemical profile, but so far it remains difficult to simultaneously characterise the major long chain lipidic constituents together with the minor but valuable unsaponifiable constituents specific to botanical species. Therefore accurate and comprehensive analytical strategies appear crucial. In this work, a NMR-based dereplication workflow was developed to decipher the metabolome of vegetable oils. The approach involves either a direct liquid-liquid extraction of minor oil constituents or a saponification treatment on the crude starting oil, followed by liquid-liquid fractionation, and direct NMR analysis of all fractions. Oil metabolites are then identified with the help of computer tools and a natural metabolite database. The whole process was applied to a grape seed oil sample, resulting in a rapid and unambiguous identification of 23 metabolites including fatty acid derivatives, triterpenes, sterols, and tocopherols. This NMR-based analytical workflow offers interesting perspectives for the chemical profiling of vegetable oils and oily extracts.
{"title":"Non-targeted NMR chemical profiling of vegetable oils: a two-path workflow for fast access to a detailed metabolome.","authors":"Anaïs Cyatwa, Joseph Thiery, Agathe Martinez, Alexis Kotland, Jane Hubert","doi":"10.1080/14786419.2026.2640144","DOIUrl":"https://doi.org/10.1080/14786419.2026.2640144","url":null,"abstract":"<p><p>Vegetable oils are increasingly used to formulate bioactive ingredients with pharmaceutical, nutraceutical or cosmeceutical applications. Their biological properties depend directly on their chemical profile, but so far it remains difficult to simultaneously characterise the major long chain lipidic constituents together with the minor but valuable unsaponifiable constituents specific to botanical species. Therefore accurate and comprehensive analytical strategies appear crucial. In this work, a NMR-based dereplication workflow was developed to decipher the metabolome of vegetable oils. The approach involves either a direct liquid-liquid extraction of minor oil constituents or a saponification treatment on the crude starting oil, followed by liquid-liquid fractionation, and direct NMR analysis of all fractions. Oil metabolites are then identified with the help of computer tools and a natural metabolite database. The whole process was applied to a grape seed oil sample, resulting in a rapid and unambiguous identification of 23 metabolites including fatty acid derivatives, triterpenes, sterols, and tocopherols. This NMR-based analytical workflow offers interesting perspectives for the chemical profiling of vegetable oils and oily extracts.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychedelic mushrooms belonging to basidiomycota have gained prominence in research due to the range of hallucinogenic compounds. To combat the challenge of antimicrobial resistance, exploring alternative antimicrobial peptides has become crucial. In this study, we present the proteomic analysis of psychedelic mushroom. Psilocybe cubensis was identified by molecular characterisation using the ITS1 and ITS4 regions. Subsequently, LC-MS/MS and gene ontology analyses were used to characterise the proteome of P. cubensis. The proteomic analysis unveiled several antimicrobial peptides. The results revealed favourable binding scores, suggesting the potential efficacy of these peptides against Staphylococcus aureus. Hence the inhibition of bacterial growth, supporting the antimicrobial properties of the identified peptides. In our findings, the individual peptides from P. cubensis against S. aureus suggest a promising avenue for the discovery of novel antimicrobial peptides.
{"title":"Proteomic analysis of psychedelic mushroom isolate and exploring potential antimicrobial peptides against bacteria","authors":"Balakrishnan Karthiyayini , Arulprakasam Karthick Raja , Sivaraj Arthi , Balakrishnan Gowdhami , Manickam Muthuselvam , Dharumadurai Dhanasekaran","doi":"10.1080/14786419.2024.2423045","DOIUrl":"10.1080/14786419.2024.2423045","url":null,"abstract":"<div><div>Psychedelic mushrooms belonging to basidiomycota have gained prominence in research due to the range of hallucinogenic compounds. To combat the challenge of antimicrobial resistance, exploring alternative antimicrobial peptides has become crucial. In this study, we present the proteomic analysis of psychedelic mushroom. <em>Psilocybe cubensis</em> was identified by molecular characterisation using the ITS1 and ITS4 regions. Subsequently, LC-MS/MS and gene ontology analyses were used to characterise the proteome of <em>P. cubensis</em>. The proteomic analysis unveiled several antimicrobial peptides. The results revealed favourable binding scores, suggesting the potential efficacy of these peptides against <em>Staphylococcus aureus</em>. Hence the inhibition of bacterial growth, supporting the antimicrobial properties of the identified peptides. In our findings, the individual peptides from <em>P. cubensis</em> against <em>S. aureus</em> suggest a promising avenue for the discovery of novel antimicrobial peptides.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 5","pages":"Pages 1277-1285"},"PeriodicalIF":1.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drug-resistant microorganisms pose a significant threat to public health as they can undermine the effectiveness of existing antibiotics and other medications. Additionally, the formation of free radicals, can contribute to various health problems. Diospyros buxifolia (D. buxifolia) belonging to Ebenaceae family is a large tropical evergreen tree utilised in traditional medicine to cure several health ailments. The present study was set out to separate bioactive speciation of aqueous and methanolic extracts of stem and leaves from D. buxifolia by using Gas Chromatography-Mass Spectrometry (GC-MS) followed by evaluation of its antimicrobial and antioxidant capabilities. GC-MS identified 14 different bioactive compounds, with four compounds common for both (leaf and stem) extracts. The methanolic extracts of leaf demonstrated significant antibacterial activity) while stem extracts exhibited notable antioxidant potential. Thus, D. buxifolia is proved source of natural antimicrobial and antioxidant agent, that could address the challenges posed by drug-resistant microorganisms and oxidative stress in global health.
{"title":"Unveiling the antibacterial and antioxidant capabilities of Diospyros buxifolia leaf and stem extracts via GC-MS analysis","authors":"Praveen Kumar Basivi , Jayaletchumi Raman , Anitha Tippana , Vijay Kakani , Reetesh Kumar , Pasupuleti Visweswara Rao , Chang Woo Kim","doi":"10.1080/14786419.2024.2425804","DOIUrl":"10.1080/14786419.2024.2425804","url":null,"abstract":"<div><div>Drug-resistant microorganisms pose a significant threat to public health as they can undermine the effectiveness of existing antibiotics and other medications. Additionally, the formation of free radicals, can contribute to various health problems. <em>Diospyros buxifolia</em> (<em>D. buxifolia</em>) belonging to Ebenaceae family is a large tropical evergreen tree utilised in traditional medicine to cure several health ailments. The present study was set out to separate bioactive speciation of aqueous and methanolic extracts of stem and leaves from <em>D. buxifolia</em> by using Gas Chromatography-Mass Spectrometry (GC-MS) followed by evaluation of its antimicrobial and antioxidant capabilities. GC-MS identified 14 different bioactive compounds, with four compounds common for both (leaf and stem) extracts. The methanolic extracts of leaf demonstrated significant antibacterial activity) while stem extracts exhibited notable antioxidant potential. Thus, <em>D. buxifolia</em> is proved source of natural antimicrobial and antioxidant agent, that could address the challenges posed by drug-resistant microorganisms and oxidative stress in global health.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 5","pages":"Pages 1338-1344"},"PeriodicalIF":1.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-04Epub Date: 2024-10-26DOI: 10.1080/14786419.2024.2423042
Karthikeyan Kandaswamy , Ajay Guru
{"title":"How peptides from venomous and poisonous animals can be used to treat oral cancer: possible mechanisms of action","authors":"Karthikeyan Kandaswamy , Ajay Guru","doi":"10.1080/14786419.2024.2423042","DOIUrl":"10.1080/14786419.2024.2423042","url":null,"abstract":"","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 5","pages":"Pages 1383-1384"},"PeriodicalIF":1.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-04Epub Date: 2024-11-04DOI: 10.1080/14786419.2024.2426208
Taniya Mary Martin , Ajay Guru
{"title":"Exploring Dendropsophin 1: a novel antimicrobial peptide from Dendropsophus columbianus for tissue regeneration in burned skin","authors":"Taniya Mary Martin , Ajay Guru","doi":"10.1080/14786419.2024.2426208","DOIUrl":"10.1080/14786419.2024.2426208","url":null,"abstract":"","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 5","pages":"Pages 1396-1397"},"PeriodicalIF":1.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-04Epub Date: 2024-10-17DOI: 10.1080/14786419.2024.2418450
Swapnil Chaturvedi , Indira P. Sarethy
Aureobasidium sp., strain TD-062, a micro colonial black yeast, was obtained as part of a screening program from the Thar Desert of India, which has been inadequately explored for novel microorganisms/bioactive metabolites. The anticancer activity of aqueous and organic solvent extracts of culture supernatant of TD-062 was investigated against A-375 myeloma and MCF-7 breast cancer cell lines. Following column chromatography, bioactive fractions were subjected to GC–MS analysis in two cycles. The GC–MS metabolite fingerprinting revealed 20 compounds belonging to various chemical groups. Further, based on observed and calculated mass ion spectra, retention time, and retention indices, many compounds could be considered novel. The second purification cycle resulted in three compounds- ATD-1, ATD-2 and ATD-3 with different calculated retention indices from that of the nearest matching compounds, squalene and tocopherol. In silico prediction study of their ADMET profiles, suggests that these new compounds have a suitable contour for use as safe anticancer drugs, without the toxicity normally associated with anticancer compounds.
{"title":"GC–MS-based metabolite fingerprinting reveals the presence of novel anticancer compounds in the microcolonial fungus Aureobasidium sp. TD-062 from the under-explored Thar Desert","authors":"Swapnil Chaturvedi , Indira P. Sarethy","doi":"10.1080/14786419.2024.2418450","DOIUrl":"10.1080/14786419.2024.2418450","url":null,"abstract":"<div><div><em>Aureobasidium sp.</em>, strain TD-062, a micro colonial black yeast, was obtained as part of a screening program from the Thar Desert of India, which has been inadequately explored for novel microorganisms/bioactive metabolites. The anticancer activity of aqueous and organic solvent extracts of culture supernatant of TD-062 was investigated against A-375 myeloma and MCF-7 breast cancer cell lines. Following column chromatography, bioactive fractions were subjected to GC–MS analysis in two cycles. The GC–MS metabolite fingerprinting revealed 20 compounds belonging to various chemical groups. Further, based on observed and calculated mass ion spectra, retention time, and retention indices, many compounds could be considered novel. The second purification cycle resulted in three compounds- ATD-1, ATD-2 and ATD-3 with different calculated retention indices from that of the nearest matching compounds, squalene and tocopherol. <em>In silico</em> prediction study of their ADMET profiles, suggests that these new compounds have a suitable contour for use as safe anticancer drugs, without the toxicity normally associated with anticancer compounds.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 5","pages":"Pages 1186-1192"},"PeriodicalIF":1.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-04Epub Date: 2024-11-02DOI: 10.1080/14786419.2024.2424402
Caixia Han , Yu Mei , Nigora Kuchkarova , Zokir Toshmatov , Shijie Fang , Hua Shao
This study investigated the allelopathic and phytotoxic effects of Elaeagnus angustifolia flower essential oil (EO) and its major constituents. Forty-one compounds were identified by GC–MS, accounting for 96.93% of the total oil, with the main compounds being ethyl cinnamate and methyl cinnamate. The allelopathic assay of the EO completely suppressed the seed germination of Lolium perenne and Amaranthus retroflexus at 22.22 mg/mL air treatment. Phytotoxic activities of ethyl cinnamate and methyl cinnamate were much stronger than those of the EO against L. perenne, with IC50 values of 0.386, 0.396, and 7.159 mg/mL, respectively. The strength of the phytotoxic activity of the major constituent ethyl cinnamate, and the mixture of ethyl cinnamate and methyl cinnamate was comparable to that of the commercial herbicide glyphosate in terms of suppressing root elongation in A. retroflexus, with IC50 values of 0.049, 0.076, and 0.017 mg/mL, respectively, indicating a possible synergistic effect of the major compounds.
{"title":"Allelopathic and phytotoxic activity of essential oil of Elaeagnus angustifolia flowers and its major constituents on Amaranthus retroflexus and Lolium perenne","authors":"Caixia Han , Yu Mei , Nigora Kuchkarova , Zokir Toshmatov , Shijie Fang , Hua Shao","doi":"10.1080/14786419.2024.2424402","DOIUrl":"10.1080/14786419.2024.2424402","url":null,"abstract":"<div><div>This study investigated the allelopathic and phytotoxic effects of <em>Elaeagnus angustifolia</em> flower essential oil (EO) and its major constituents. Forty-one compounds were identified by GC–MS, accounting for 96.93% of the total oil, with the main compounds being ethyl cinnamate and methyl cinnamate. The allelopathic assay of the EO completely suppressed the seed germination of <em>Lolium perenne</em> and <em>Amaranthus retroflexus</em> at 22.22 mg/mL air treatment. Phytotoxic activities of ethyl cinnamate and methyl cinnamate were much stronger than those of the EO against <em>L. perenne</em>, with IC<sub>50</sub> values of 0.386, 0.396, and 7.159 mg/mL, respectively. The strength of the phytotoxic activity of the major constituent ethyl cinnamate, and the mixture of ethyl cinnamate and methyl cinnamate was comparable to that of the commercial herbicide glyphosate in terms of suppressing root elongation in <em>A. retroflexus</em>, with IC<sub>50</sub> values of 0.049, 0.076, and 0.017 mg/mL, respectively, indicating a possible synergistic effect of the major compounds.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 5","pages":"Pages 1308-1317"},"PeriodicalIF":1.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study explores the bioactivity potential of four indigenous Ganoderma species from northern Serbia (G. applanatum, G. lucidum, G. pfeifferi, and G. resinaceum), comparing antioxidant and anti-acetylcholinesterase (anti-AChE) properties. The mycochemical profile, including ethanol (EtOH), water (H2O), and chloroform (CHCl3) extracts, was analysed, revealing significant phenolic compounds, such as 2,5-dihydroxybenzoic acid. Highest total phenolic content (TP) was in EtOH extracts (205 - 380 mg GAE/g d.w.), and total carbohydrate content peaked in G. pfeifferi CHCl3 extracts (1895 ± 0.29 mg GluE/g d.w., 439 ± 0.42 mg FruE/g d.w.). DPPH and FRAP activities were prominent in G. applanatum H2O extracts, while CHCl3 extracts excelled in the NO assay, and EtOH extracts were superior in the ABTS assay. The most effective AChE inhibitors were polar extracts from G. pfeifferi. These findings emphasise the potential therapeutic use of Ganoderma species, particularly G. pfeifferi, in combating oxidative stress and acetylcholine deficiencies.
{"title":"Exploring the bioactivity potential of indigenous Ganoderma species from Northern Serbia: insights into antioxidant and anti-acetylcholinesterase properties","authors":"Milena Rašeta , Jovana Mišković , Nenad Krsmanović , Eleonora Čapelja , Sanja Berežni , Diandra Pintać Šarac , Maja Karaman","doi":"10.1080/14786419.2024.2415437","DOIUrl":"10.1080/14786419.2024.2415437","url":null,"abstract":"<div><div>This study explores the bioactivity potential of four indigenous <em>Ganoderma</em> species from northern Serbia (<em>G. applanatum</em>, <em>G. lucidum</em>, <em>G. pfeifferi</em>, and <em>G. resinaceum</em>), comparing antioxidant and anti-acetylcholinesterase (anti-AChE) properties. The mycochemical profile, including ethanol (EtOH), water (H<sub>2</sub>O), and chloroform (CHCl<sub>3</sub>) extracts, was analysed, revealing significant phenolic compounds, such as 2,5-dihydroxybenzoic acid. Highest total phenolic content (TP) was in EtOH extracts (205 - 380 mg GAE/g d.w.), and total carbohydrate content peaked in <em>G. pfeifferi</em> CHCl<sub>3</sub> extracts (1895 ± 0.29 mg GluE/g d.w., 439 ± 0.42 mg FruE/g d.w.). DPPH and FRAP activities were prominent in <em>G. applanatum</em> H<sub>2</sub>O extracts, while CHCl<sub>3</sub> extracts excelled in the NO assay, and EtOH extracts were superior in the ABTS assay. The most effective AChE inhibitors were polar extracts from <em>G. pfeifferi</em>. These findings emphasise the potential therapeutic use of <em>Ganoderma</em> species, particularly <em>G. pfeifferi,</em> in combating oxidative stress and acetylcholine deficiencies.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 5","pages":"Pages 1149-1160"},"PeriodicalIF":1.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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