Natural Product Research最新文献

英文中文

In vitro and in silico evaluation of the anti-leishmania activity of synthetic chalcones 合成查耳酮抗利什曼病活性的体外和硅学评估

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-01-02 DOI: 10.1080/14786419.2024.2401499

Fernando Ferreira Leite , Luis Cezar Rodrigues , Bruno Hanrry Melo de Oliveira , Gabrielly Diniz Duarte , Maria Denise Leite Ferreira , Natália Ferreira de Sousa , Shayenne Eduarda Ramos Vanderley , Leonardo Lima Cardoso , Tatjana Souza Lima Keesen , Rodrigo Santos Aquino de Araújo , Luciana Scotti , Marcus Tullius Scotti , Francisco Jaime Bezerra Mendonça-Junior

Leishmaniasis is a group of neglected, vector-borne infectious diseases that affect millions of people around the world. The medications available for its treatment, especially in cases of visceral leishmaniasis, are old, outdated and have serious side effects. In this work, 10 chalcones were synthesised and evaluated in vitro against promastigotes and axenic amastigotes of Leishmania infantum. Compounds CP04 and CP06 were the most promising, respectively presenting IC₅₀ values = 13.64 ± 0.25 and 11.19 ± 0.22 µM against promastigotes, and IC₅₀ = 18.92 ± 0.05 and 22.42 ± 0.05 µM against axenic amastigotes. Only compound CP04 did not show cytotoxicity against peripheral blood mononuclear cells (PBMCs). Molecular docking studies conducted with sterol 14-alpha demethylase (CYP-51) (PDB: 3L4D) and trypanothione reductase (PDB: 5EBK) enzymes from L. infantum evidenced the great affinity of compound CP04 for these targets, presenting Moldock score values of −94.0758 and −50.5692 KJ/mol⁻¹.

利什曼病是一组被忽视的病媒传染病，影响着全世界数百万人。治疗利什曼病的药物，尤其是治疗内脏利什曼病的药物...

{"title":"In vitro and in silico evaluation of the anti-leishmania activity of synthetic chalcones","authors":"Fernando Ferreira Leite , Luis Cezar Rodrigues , Bruno Hanrry Melo de Oliveira , Gabrielly Diniz Duarte , Maria Denise Leite Ferreira , Natália Ferreira de Sousa , Shayenne Eduarda Ramos Vanderley , Leonardo Lima Cardoso , Tatjana Souza Lima Keesen , Rodrigo Santos Aquino de Araújo , Luciana Scotti , Marcus Tullius Scotti , Francisco Jaime Bezerra Mendonça-Junior","doi":"10.1080/14786419.2024.2401499","DOIUrl":"10.1080/14786419.2024.2401499","url":null,"abstract":"<div><div>Leishmaniasis is a group of neglected, vector-borne infectious diseases that affect millions of people around the world. The medications available for its treatment, especially in cases of visceral leishmaniasis, are old, outdated and have serious side effects. In this work, 10 chalcones were synthesised and evaluated <em>in vitro</em> against promastigotes and axenic amastigotes of <em>Leishmania infantum</em>. Compounds CP04 and CP06 were the most promising, respectively presenting IC<sub>50</sub> values = 13.64 ± 0.25 and 11.19 ± 0.22 µM against promastigotes, and IC<sub>50</sub> = 18.92 ± 0.05 and 22.42 ± 0.05 µM against axenic amastigotes. Only compound CP04 did not show cytotoxicity against peripheral blood mononuclear cells (PBMCs). Molecular docking studies conducted with sterol 14-alpha demethylase (CYP-51) (PDB: 3L4D) and trypanothione reductase (PDB: 5EBK) enzymes from <em>L. infantum</em> evidenced the great affinity of compound CP04 for these targets, presenting Moldock score values of −94.0758 and −50.5692 KJ/mol<sup>−1</sup>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 1","pages":"Pages 196-207"},"PeriodicalIF":1.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First comprehensive report on the chemical composition of the floral perfume of Notylia (Orchidaceae) 本文首次综合报道了兰科植物诺提利亚花香的化学成分。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-01-02 DOI: 10.1080/14786419.2024.2448851

Miguel Sena de Oliveira , Mozaniel Santana de Oliveira , Lidiane Diniz do Nascimento , Edlley Max Pessoa , Eloisa Helena de Aguiar Andrade , Pedro Lage Viana

This study presents the first complete analysis of the chemical composition of the flowers of the species N. fragrans and N. microchila. The compounds were extracted via distillation and simultaneous extraction and analysed using gas chromatography coupled to mass spectrometry. A total of 82 compounds were identified and the results reveal significant differences in the abundance of compounds between the species. While N. fragrans has eugenol as its majority compound, N. microchila exhibits high concentrations of (E)-β-farnesene. In addition, remarkable concentrations of secondary compounds such as methyl-eugenol, β-bisabolene, germacrene D, 1-octadecene, hexadecyl acetate and ipsdienol were observed and are demonstrably related to the processes of attraction of pollinators, such as euglossine bees, by Orchidaceae. The findings of the study offer valuable insights into the ecology and reproductive biology of the species studied, and also present taxonomic potential for the phytochemical data.

本研究首次完整地分析了香芸苔属（N. fragrans）和微花芸苔属（N. microchila）花的化学成分。通过蒸馏法和同时萃取法提取化合物，并采用气相色谱-质谱联用法进行分析。共鉴定出82种化合物，结果显示不同物种间化合物丰度存在显著差异。虽然香菊属植物以丁香酚为主要化合物，但微紫菊属植物表现出高浓度的(E)-β-法尼辛。此外，还观察到甲基丁香酚、β-双abolene、germacrene D、1-十八烯、十六烷基乙酸酯和异二烯醇等二级化合物的显著浓度，这些化合物与兰科植物吸引传粉者（如eugineine蜜蜂）的过程有关。该研究结果为研究物种的生态学和生殖生物学提供了有价值的见解，并为植物化学数据提供了分类潜力。

{"title":"First comprehensive report on the chemical composition of the floral perfume of Notylia (Orchidaceae)","authors":"Miguel Sena de Oliveira , Mozaniel Santana de Oliveira , Lidiane Diniz do Nascimento , Edlley Max Pessoa , Eloisa Helena de Aguiar Andrade , Pedro Lage Viana","doi":"10.1080/14786419.2024.2448851","DOIUrl":"10.1080/14786419.2024.2448851","url":null,"abstract":"<div><div>This study presents the first complete analysis of the chemical composition of the flowers of the species <em>N. fragrans</em> and <em>N. microchila</em>. The compounds were extracted <em>via</em> distillation and simultaneous extraction and analysed using gas chromatography coupled to mass spectrometry. A total of 82 compounds were identified and the results reveal significant differences in the abundance of compounds between the species. While <em>N. fragrans</em> has eugenol as its majority compound, <em>N. microchila</em> exhibits high concentrations of (<em>E</em>)-<em>β</em>-farnesene. In addition, remarkable concentrations of secondary compounds such as methyl-eugenol, <em>β</em>-bisabolene, germacrene D, 1-octadecene, hexadecyl acetate and ipsdienol were observed and are demonstrably related to the processes of attraction of pollinators, such as euglossine bees, by Orchidaceae. The findings of the study offer valuable insights into the ecology and reproductive biology of the species studied, and also present taxonomic potential for the phytochemical data.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 1","pages":"Pages 289-295"},"PeriodicalIF":1.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green synthesis of silver nano-insecticide from Polygonum hydropipper (Polygonaceae) 从蓼属植物中绿色合成纳米银杀虫剂。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-01-02 DOI: 10.1080/14786419.2024.2405015

C.R. Chandana , Surajit Kalita , Pulin Patgiri , Pranjal Kumar Kaman

Developing eco-friendly and cost-effective green synthesis of metallic nanoparticles using an array of natural resources has garnered significant interest in recent years for their diverse sustainable applications, including agriculture. In our present investigation for green synthesis of silver nanoparticles (AgNPs), phytochemicals present on the Polygonum hydropipper (Family: Polygonaceae) leaf extract acted as a reducing and stabilising agent owing to their active phytoconstituents. Biosynthesis of AgNPs was confirmed using various physio-chemical methods including UV-Vis spectrophotometry, Dynamic Light Scattering (DLS) analysis, Zeta potential, Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM). The Fourier Transform Infra-red Spectrograph (FTIR) analysis revealed strong peaks in the range of 638–3246.3 cm⁻¹, confirming the presence of various functional groups viz., O-H, C-H, C = C and O = C = O on the biosynthesized compound. The methodology employed in our study for the biosynthesis of AgNPs utilising P. hydropiper leaf extract exhibits significant potential for future technological advancements.

近年来，利用一系列自然资源开发生态友好型和具有成本效益的金属纳米粒子绿色合成技术因其在农业等领域的多种可持续应用而备受关注。在我们目前进行的银纳米粒子（AgNPs）绿色合成研究中，蓼科植物蓼（Polygonum hydropipper）叶提取物中的植物化学物质因其活性植物成分而成为还原剂和稳定剂。AgNPs 的生物合成采用了多种物理化学方法，包括紫外可见分光光度法、动态光散射（DLS）分析、Zeta 电位、透射电子显微镜（TEM）和扫描电子显微镜（SEM）。傅立叶变换红外光谱仪（FTIR）分析表明，在 638-3246.3 cm-1 范围内有较强的峰值，证实了生物合成化合物中存在各种官能团，即 O-H、C-H、C = C 和 O = C = O。我们的研究中采用的利用水黄柏叶提取物生物合成 AgNPs 的方法为未来的技术进步展示了巨大的潜力。

{"title":"Green synthesis of silver nano-insecticide from Polygonum hydropipper (Polygonaceae)","authors":"C.R. Chandana , Surajit Kalita , Pulin Patgiri , Pranjal Kumar Kaman","doi":"10.1080/14786419.2024.2405015","DOIUrl":"10.1080/14786419.2024.2405015","url":null,"abstract":"<div><div>Developing eco-friendly and cost-effective green synthesis of metallic nanoparticles using an array of natural resources has garnered significant interest in recent years for their diverse sustainable applications, including agriculture. In our present investigation for green synthesis of silver nanoparticles (AgNPs), phytochemicals present on the <em>Polygonum hydropipper</em> (Family: Polygonaceae) leaf extract acted as a reducing and stabilising agent owing to their active phytoconstituents. Biosynthesis of AgNPs was confirmed using various physio-chemical methods including UV-Vis spectrophotometry, Dynamic Light Scattering (DLS) analysis, Zeta potential, Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM). The Fourier Transform Infra-red Spectrograph (FTIR) analysis revealed strong peaks in the range of 638–3246.3 cm<sup>−1</sup>, confirming the presence of various functional groups <em>viz</em>., O-H, C-H, C = C and O = C = O on the biosynthesized compound. The methodology employed in our study for the biosynthesis of AgNPs utilising <em>P. hydropiper</em> leaf extract exhibits significant potential for future technological advancements.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 1","pages":"Pages 250-259"},"PeriodicalIF":1.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new tetrahydroxybenzophenone from a marine-associated fungus of penicillium sp. and its potential antibacterial activity 来自海洋相关真菌青霉菌的一种新的四羟基二苯甲酮及其潜在的抗菌活性。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-01-02 DOI: 10.1080/14786419.2024.2404651

Ruifeng Huang , Shuaiqi Ma , Jiale Wu , Asma Riaz , Li Song , Shaofen Zhou , Runhong Zhou , Jingnan Qiu , Jian He

Penicillium species are renowned for their ability to produce a wide range of secondary metabolites with medicinal properties. In this study, compounds 1-10 were isolated from Penicillium sp. Z-16, of which compound 1 is a new benzophenone derivative named methyl 2-(2,6-dihydroxy-4-methylbenzoyl)-4,5-dihydroxy-3-methoxybenzoate. The chemical structure of 1 was determined through comprehensive spectroscopic analysis, including 1D, 2D NMR (HMBC, HSQC) and HRESIMS. In addition, six other known compounds (11-16) were isolated and identified from Penicillium sp. T-5-1. The antimicrobial activity tests demonstrated that compound 1 was moderately active against Candida albicans with a MIC value of 125 μg/mL, while compound 2 showed a MIC value of 62.5 μg/mL against Staphylococcus aureus.

青霉菌因能产生多种具有药用价值的次级代谢产物而闻名于世。本研究从青霉 Z-16 中分离出了 1-10 号化合物，其中 1 号化合物是一种新的二苯甲酮衍生物，名为 2-(2,6-二羟基-4-甲基苯甲酰基)-4,5-二羟基-3-甲氧基苯甲酸甲酯。通过全面的光谱分析，包括一维、二维核磁共振（HMBC、HSQC）和 HRESIMS，确定了 1 的化学结构。此外，还从青霉 T-5-1 中分离并鉴定出了其他六个已知化合物（11-16）。抗菌活性测试表明，化合物 1 对白色念珠菌具有中等活性，其 MIC 值为 125 μg/mL，而化合物 2 对金黄色葡萄球菌的 MIC 值为 62.5 μg/mL。

引用次数: 0

Two new phenolic glycosides from the roots of Iris domestica (L.) Goldblatt & Mabb and their cytotoxic activity 从鸢尾（L. ）Goldblatt & Mabb 的根中提取的两种新的酚苷及其细胞毒性活性。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-01-02 DOI: 10.1080/14786419.2024.2404659

Tieqiang Zong , Lantian Cui , Jinfeng Sun , Zhengyu Hu , Pengcheng Yang , Mingxia Li , Mei Jin , Wei Zhou , Gao Li

Two new phenolic glycosides, Diplostephioside D (1) and Diplostephioside E (2) together with ten known phenols (3–12) were isolated from the dried roots of Iris domestica (L.) Goldblatt & Mabb. Among them, compounds 4–9 have not been reported previously from the family Iridaceae. The chemical structures were elucidated based on extensive spectroscopic experiments, including 1D and 2D NMR as well as HR-ESI-MS, and comparison with those reported in the literature. All of the isolated compounds were evaluated for their cytotoxic activity against HeLa cells. Compounds 1, 2, 4, 8 and 12 showed cytotoxic activities with IC₅₀ values ranging from 13.52 ± 1.52 to 53.33 ± 1.40 μM.

从鸢尾花（L. ）Goldblatt & Mabb 的干燥根中分离出了两种新的酚类糖苷--二去氢糖苷 D（1）和二去氢糖苷 E（2）以及十种已知的酚类物质（3-12）。其中，化合物 4-9 以前从未在鸢尾科植物中报道过。通过一维和二维核磁共振以及 HR-ESI-MS 等大量光谱实验，并与文献报道进行对比，阐明了这些化合物的化学结构。评估了所有分离化合物对 HeLa 细胞的细胞毒性活性。化合物 1、2、4、8 和 12 显示出细胞毒性活性，IC50 值介于 13.52 ± 1.52 至 53.33 ± 1.40 μM。

引用次数: 0

Extractive optimization of bioactive compounds in aerial parts of cuphea carthagenensis using Box-Behnken experimental design 采用Box-Behnken实验设计优化龙参地上部生物活性成分的提取。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-01-02 DOI: 10.1080/14786419.2024.2448845

Nilza Alves de Oliveira Jacobucci , M. M. Pinc , Mariana Dalmagro , Joice Karina Otênio Ribeiro , Talita Anielle de Assunção , Elissandro Jair Klein , Edson Antônio da Silva , Paula Derksen Macruz , Ezilda Jacomassi , Odair Alberton , Jaqueline Hoscheid

Cuphea carthagenensis is known for its potential antioxidant and anti-inflammatory properties, attributed to triterpenes, flavonoids, and tannins. This study aimed to optimise the extraction process for aerial parts of C. carthagenensis using vortex extraction. A Box-Behnken experimental design coupled with response surface methodology was employed to evaluate the effects of three independent variables: sample-to-solvent ratio, velocity, and temperature. The optimised extract underwent phytochemical screening and assessment of its antimicrobial capacity. The highest extraction yields were obtained through maceration (22.84%) and ultrasound-assisted extraction (21.95%). However, the extract by vortex extraction exhibited significantly higher phenolic content (250.17 µg_EAG g_ext⁻¹) and antioxidant capacity. The optimal extraction conditions were identified as a sample-to-solvent ratio of 1:35, 12,000 rpm, and a temperature of 60 °C. The optimised extract was characterised by a predominance of glycosylated flavonoids and demonstrated moderate antibacterial activity, particularly against Streptococcus pyogenes, Staphylococcus epidermidis, and Bacillus subtilis.

Cuphea carthagenensis因其潜在的抗氧化和抗炎特性而闻名，归因于三萜，类黄酮和单宁。本研究旨在优化旋涡提取法提取红花地上部分的工艺条件。采用Box-Behnken实验设计结合响应面法，对样品与溶剂比、速度和温度三个自变量的影响进行了评价。优化后的提取物进行了植物化学筛选和抗菌能力评估。浸出率最高（22.84%），超声辅助提取率最高（21.95%）。而涡旋提取液的酚类物质含量（250.17µgEAG）和抗氧化能力显著提高。最佳提取条件为料液比1:35，转速12000 rpm，提取温度60℃。优化后的提取物具有糖基化黄酮类化合物的优势，并表现出适度的抗菌活性，特别是对化脓性链球菌、表皮葡萄球菌和枯草芽孢杆菌。

{"title":"Extractive optimization of bioactive compounds in aerial parts of cuphea carthagenensis using Box-Behnken experimental design","authors":"Nilza Alves de Oliveira Jacobucci , M. M. Pinc , Mariana Dalmagro , Joice Karina Otênio Ribeiro , Talita Anielle de Assunção , Elissandro Jair Klein , Edson Antônio da Silva , Paula Derksen Macruz , Ezilda Jacomassi , Odair Alberton , Jaqueline Hoscheid","doi":"10.1080/14786419.2024.2448845","DOIUrl":"10.1080/14786419.2024.2448845","url":null,"abstract":"<div><div><em>Cuphea carthagenensis</em> is known for its potential antioxidant and anti-inflammatory properties, attributed to triterpenes, flavonoids, and tannins. This study aimed to optimise the extraction process for aerial parts of <em>C. carthagenensis</em> using vortex extraction. A Box-Behnken experimental design coupled with response surface methodology was employed to evaluate the effects of three independent variables: sample-to-solvent ratio, velocity, and temperature. The optimised extract underwent phytochemical screening and assessment of its antimicrobial capacity. The highest extraction yields were obtained through maceration (22.84%) and ultrasound-assisted extraction (21.95%). However, the extract by vortex extraction exhibited significantly higher phenolic content (250.17 µg<sub>EAG</sub> g<sub>ext</sub><sup>−1</sup>) and antioxidant capacity. The optimal extraction conditions were identified as a sample-to-solvent ratio of 1:35, 12,000 rpm, and a temperature of 60 °C. The optimised extract was characterised by a predominance of glycosylated flavonoids and demonstrated moderate antibacterial activity, particularly against <em>Streptococcus pyogenes</em>, <em>Staphylococcus epidermidis</em>, and <em>Bacillus subtilis</em>.</div></div>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":"40 1","pages":"Pages 283-288"},"PeriodicalIF":1.6,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two novel carbon skeleton compounds from Portulaca oleracea L. and their effects on nitric oxide 马齿苋中的两种新型碳骨架化合物及其对一氧化氮的影响

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-01-02 DOI: 10.1080/14786419.2024.2381653

Yingdai Zhao , Hongzhe Zhang , Shengnan Guo , Jinhuan Wang , Junjie Yao , Fan He , Xixiang Ying

Two new carbon skeleton compounds, identified as 2-(1-(3-hydroxy-2,2,6-trimethyl-6-vinyltetrahydro-2H-pyran-3-yl)-2-methylpropoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol named Olerapyran A (1), and (E)-3-(6-acetyl-2-methyl-5-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)cyclooctylidene)butan-2-one named Oleraoctyl (2), were first isolated from Portulaca oleracea L., then their structures were determined using spectroscopic methods, including UHPLC-ESI-QTOF/MS, 1D and 2D NMR. In addition, the activities of Olerapyran A and Oleraoctyl inhibiting nitric oxide (NO) were studied.

两种新的碳骨架化合物被鉴定为 2-(1-(3-羟基-2,2,6-三甲基-6-乙烯基四氢-2H-吡喃-3-基)-2-甲基丙氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇，命名为 Olerapyran A (1)、和(E)-3-(6-乙酰基-2-甲基-5-((3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)环辛基亚基)丁-2-酮，名为 Oleraoctyl (2)。,然后利用 UHPLC-ESI-QTOF/MS, 1D 和 2D NMR 等光谱方法确定了它们的结构。此外，还对 Olerapyran A 和 Oleraoctyl 抑制一氧化氮（NO）的活性进行了研究。

引用次数: 0

Simultaneous determination of cucurbitacins B, D, and E in Cucurbita seed oils by HPLC-DAD 利用 HPLC-DAD 同时测定葫芦籽油中的葫芦素 B、D 和 E。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-01-02 DOI: 10.1080/14786419.2024.2394097

Elizabeth Goya-Jorge , María Elisa Jorge-Rodríguez , Yanelis Saucedo-Hernández

Cucurbitacins are triterpene bioactive constituents of natural products, particularly in the Cucurbitaceae plant family. The presence of cucurbitacins in seeds of the Cucurbita genus (pumpkin) has been only little studied. In this work, the content of cucurbitacins B, D, and E in seed oils from three cucurbits (Cucurbita moschata Duch, Cucurbita pepo Linn, and Cucurbita maxima Linn) was studied. An analytical method based on HPLC-DAD for the detection and quantification of these three cucurbitacins in seed oils was developed and validated according to ICH guidelines. The method showed good linearity, accuracy, and precision for the simultaneous quantification of cucurbitacins B, D, and E using C.moschata seed oil as a reference. When applied to C.pepo and C.maxima seed oils, cucurbitacin B and D were quantified but to a lesser extent. This is the first report of a simple, repeatable, and reproducible analytical tool to identify cucurbitacins in oilseeds from Cucurbita spp.

葫芦素是天然产品中的三萜类生物活性成分，尤其是葫芦科植物中的葫芦素。有关葫芦科植物（南瓜）种子中葫芦素含量的研究很少。本研究对三种葫芦科植物（Cucurbita moschata Duch、Cucurbita pepo Linn 和 Cucurbita maxima Linn）种子油中葫芦素 B、D 和 E 的含量进行了研究。根据 ICH 指南，建立并验证了基于 HPLC-DAD 的分析方法，用于检测和定量种子油中的这三种葫芦素。该方法以C.moschata种子油为参照物，对葫芦巴苷B、D和E的同时定量具有良好的线性、准确性和精密度。当应用于 C.pepo 和 C.maxima 种子油时，葫芦素 B 和 D 也得到了定量，但定量程度较低。这是首次报道用一种简单、可重复和可再现的分析工具来鉴定葫芦科植物油籽中的葫芦素。

引用次数: 0

The protective effects of alkaloids from Stephania tetrandra S. Moore on H9C2 cardiomyocytes. 防己藤生物碱对H9C2心肌细胞的保护作用。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-01-02 DOI: 10.1080/14786419.2025.2605665

Yan-Nan Ji, Ran Zhou, Zhi-Hui Zhang, Xing-Ru Gao, Si-Qian Yang, Pu-Yu Yang, Zi-Shan Chen, Jun-Li Sha, Jing-Yu He, Yue-Feng Zhang, Tie-Jun Zhang, Yu-Cheng Gu, Rui-Xia Guo

Alkaloids from Stephania tetrandra S. Moore, particularly tetrandrine, show cardioprotective effects in H9C2 cardiomyocytes under hypoxia/reoxygenation (H/R) injury. Using acid-base extraction and thin-layer chromatography (TLC), HPD-100 resin, Sephadex LH-20, preparative liquid chromatography (prep-HPLC), total alkaloids were purified. In H/R-induced injury (cell viability: 33%), tetrandrine significantly improved viability to 70% and reduced Lactate Dehydrogenase (LDH) release (284-136 U/I), outperforming fangchinoline (viability: 48%; LDH: 223 U/I). Tetrandrine also enhanced glucose consumption (0.62-1.66 nM), lactate production (0.2-0.64 nM), and ATP concentration (5-22 nmoL/mg protein), suggesting metabolic protection. These findings highlight tetrandrine's potential in mitigating myocardial ischemia/reperfusion injury.

粉防己碱对缺氧/再氧化（H/R）损伤的H9C2心肌细胞具有心脏保护作用。采用酸碱萃取薄层色谱（TLC）、HPD-100树脂、Sephadex LH-20、制备液相色谱（prep-HPLC）对总生物碱进行纯化。在H/ r诱导的损伤（细胞活力33%）中，粉防己碱显著提高细胞活力至70%，降低乳酸脱氢酶（LDH）释放（284-136 U/I），优于防己胆碱（活力48%，LDH: 223 U/I）。粉防己碱还能提高葡萄糖消耗（0.62-1.66 nM）、乳酸生成（0.2-0.64 nM）和ATP浓度（5-22 nmoL/mg蛋白），提示代谢保护作用。这些发现强调了粉防己碱在减轻心肌缺血/再灌注损伤方面的潜力。

引用次数: 0

Four new phenylpropanoid glycosides from the leaves of Illicium dunnianum and their neuroprotective activities 从 Illicium dunnianum 叶子中提取的四种新的苯丙苷及其神经保护活性。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-01-02 DOI: 10.1080/14786419.2024.2386396

Hai-bo Li , Xiao-qing He , Qian-qian Pang , Zhen-zhong Wang , Yong-wen Zhang , Xin-sheng Yao , Yang Yu

Four previously unreported phenylpropanoid glycosides (1–4), together with four known analogues (5–8), were isolated from the leaves of Illicium dunnianum. The structures of these new compounds were elucidated based on spectroscopic analysis (HR-ESI-MS, NMR, IR, UV) and chemical methods. In addition, the neuroprotective activities of all the isolates were evaluated by measuring their cell viability in H₂O₂-induced OLN-93 cell injury model.

从 Illicium dunnianum 的叶子中分离出了四种以前未报道过的苯丙苷类化合物（1-4）以及四种已知的类似物（5-8）。通过光谱分析（HR-ESI-MS、NMR、IR、UV）和化学方法阐明了这些新化合物的结构。此外，通过测定 H2O2- 诱导的 OLN-93 细胞损伤模型中细胞的存活率，评估了所有分离物的神经保护活性。

引用次数: 0

首页上一页

下一页尾页

类型

全部化学•材料生命科学医学物理工程技术环境•农林材料科学地球科学法学管理学化学环境科学与生态学计算机科学教育学经济学农林科学人文科学生物学数学物理与天体物理心理学综合性期刊其他工业工程理学历史学农学文学信息工程

数据库

全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley

期刊

Natural Product Research

全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.

﹀