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Phytochemicals and health-promoting evaluations of Ophiorrhiza puffii, a chinese endemic plant 一种中国特有的植物 Ophiorrhiza puffii 的植物化学成分和健康促进评估。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-02-01 DOI: 10.1080/14786419.2024.2425808

Qing Bu , Qi-Bin Yang , Zeng-Yue Ge , Ze-Xiong Shi , Lin-Fu Liang

There has been no phytochemical or and pharmacological report of the Chinese endemic plant Ophiorrhiza puffii till now. At present, seven structurally diverse compounds were obtained, including six triterpenoids (1–6) and one anthraquinone (7). Interestingly, 1–6 furnished three distinct carbon skeletons. Additionally, these phytochemical constituents showed multiple health-promoting effects. Triterpene 3 displayed considerable tyrosinase inhibitory activity (IC₅₀ = 5.42 μM). Components 4 and 5 demonstrated significant antioxidant activity (IC₅₀ = 4.23 and 2.03 mM, respectively). Meanwhile, compounds 2 and 5 exhibited moderate α-glucosidase inhibitory activity (IC₅₀ = 0.89 and 0.72 mM, respectively). Moreover, the binding mechanisms for bioactive compounds 2, 3 and 5 and the corresponding α-glucosidase and tyrosinase proteins were preliminarily inspected by molecular docking experiments. This study filled up the knowledge gap of the unexplored chemical and biological profiles of secondary metabolites from the plant O. puffii for the first time.

迄今为止，还没有关于中国特有植物桔梗（Ophiorrhiza puffii）的植物化学或药理报告。本次研究共获得了 7 种结构不同的化合物，包括 6 种三萜类化合物（1-6）和 1 种蒽醌类化合物（7）。有趣的是，1-6 提供了三种不同的碳骨架。此外，这些植物化学成分还显示出多种促进健康的作用。三萜 3 具有相当强的酪氨酸酶抑制活性（IC50 = 5.42 μM）。成分 4 和 5 具有显著的抗氧化活性（IC50 分别为 4.23 和 2.03 mM）。同时，化合物 2 和 5 表现出适度的 α-葡萄糖苷酶抑制活性（IC50 = 0.89 和 0.72 mM）。此外，还通过分子对接实验初步研究了生物活性化合物 2、3 和 5 与相应的 α-葡萄糖苷酶和酪氨酸酶蛋白的结合机制。该研究首次填补了尚未探索的浮萍属植物次生代谢物化学和生物学特征的知识空白。

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引用次数: 0

Comparative metabolomics-based screening of fruit extracts of less-known melon (Cucumis melo var. agrestis) accessions collected from dry terrain of North India by using HPLC–DAD 利用 HPLC-DAD 对从印度北部干旱地区采集的鲜为人知的甜瓜（Cucumis melo var. agrestis）品种的果实提取物进行基于代谢组学的比较筛选。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-02-01 DOI: 10.1080/14786419.2024.2424398

Chanchal Sharma , Jyoti Rani , Manish Kapoor , Navneet Kaur , Sandeep Gawdiya , Saroj Kumar Pradhan

Cucumis melo var. agrestis (Naudin) is an important wild crop that belongs to the family Cucurbitaceae. Fruits possess digestive, stomachic, vermifuge and febrifuge properties and possess analgesic, antioxidant, antibacterial and anti-inflammatory activities. Current research is aimed at screening diverse phytoconstituents present in the fruit extract of wild melon (C. melo var. agrestis) with the technique of high-performance liquid chromatography (HPLC). Our outcomes showed that fruit extract of C. melo var. agrestis has various phytochemicals such as glycosides, alkaloids, phenols, flavonoids, saponins, tannins, proteins, amino acids and carbohydrates. HPLC analysis revealed that naringenin and catechin were reported to have the highest concentrations among the all studied accessions. PCA and HCA multivariant analysis showed that, first two principal components, i.e. PC1 and PC2 contributed to 54.87% of the variation, where maximum loadings were from apigenin, trailed by gallic acid, rutin, and catechol.

agrestis (Naudin)是葫芦科的一种重要野生作物。果实具有消化、健胃、驱虫和清热的功效，并具有镇痛、抗氧化、抗菌和消炎的活性。目前的研究旨在利用高效液相色谱（HPLC）技术筛选野甜瓜（C. melo var. agrestis）果实提取物中的多种植物成分。结果表明，野甜瓜果实提取物中含有多种植物化学物质，如甙类、生物碱、酚类、黄酮类、皂苷、单宁酸、蛋白质、氨基酸和碳水化合物。HPLC 分析表明，在所有研究品种中，柚皮苷和儿茶素的含量最高。PCA 和 HCA 多变量分析表明，前两个主成分（即 PC1 和 PC2）占变异的 54.87%，其中芹菜苷的载荷最大，其次是没食子酸、芦丁和儿茶酚。

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引用次数: 0

Lariciresinol: a potent natural compound with diverse therapeutic and health benefits. 落叶松树脂醇：一种有效的天然化合物，具有多种治疗和健康益处。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-02-01 DOI: 10.1080/14786419.2025.2611424

Ijaz Hussain, Azhar Rasul, Mudassir Hassan, Ravi Rawat, Yusuf Tutar

Scientific research has identified lariciresinol among lignan types, which shows potential against cancer development and bacterial infections in addition to serving as an antioxidant that affects oestrogen activity while blocking inflammation. The review analyses the detailed medical and biological properties of lariciresinol. The two Brassicaceae plant genera Isatis indigotica and Brassica oleracea contain this substance, which exists in various plant types. The compound demonstrated anticancer properties through its mechanisms of stopping cancer cell multiplication and triggering programmed cell death. Recent research found that lariciresinol can block the function of the virus that causes COVID-19 by reducing its ability to enter the cells and proliferate. Lariciresinol antiviral actions have been shown to reduce RNA and viral protein production. The diverse impacts indicate that lariciresinol is a potential compound for novel health solutions and future therapeutic innovations.

科学研究已经确定了木脂素类型中的松脂醇，它显示出抗癌和细菌感染的潜力，除了作为一种抗氧化剂，影响雌激素活性，同时阻断炎症。本文详细分析了松柏树脂醇的医学和生物学特性。两种芸苔科植物蓝靛属和甘蓝属含有这种物质，它存在于各种植物类型中。该化合物通过其阻止癌细胞增殖和触发程序性细胞死亡的机制显示出抗癌特性。最近的研究发现，松叶松醇可以通过降低病毒进入细胞和增殖的能力来阻止导致COVID-19的病毒的功能。落叶松醇的抗病毒作用已被证明可以减少RNA和病毒蛋白的产生。不同的影响表明，落叶松树脂醇是一种潜在的新型健康解决方案和未来治疗创新的化合物。

引用次数: 0

Herpetosin A, a nor-cucurbitane triterpenoid with a 5/6/6/5 ring system from Herpetospermum pedunculosum Herpetosin A，一种来自 Herpetospermum pedunculosum 的具有 5/6/6/5 环系统的非葫芦烷三萜类化合物。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-02-01 DOI: 10.1080/14786419.2024.2424399

Qianyu Chen , Yingxiong Ma , Zhaoyue Dong , Bing Xu , Guowei Wang , Xiaozhong Lan , Zhihua Liao , Min Chen

Two previously undescribed triterpenoids, herpetosin A (1) and herpetosin B (2), together with two known compounds, cucurbitacin B (3) and dihydrocucurbitacin E (4), were isolated from the seeds of Herpetospermum pedunculosum. Their structures were elucidated by analysis of the NMR, HR-ESI-MS, X-ray data and quantum chemical calculation. Compound 1 featured an unprecedented nor-cucurbitane triterpenoid skeleton with a 5/6/6/5 ring system. Among all the isolates, compound 4 exhibited anti-proliferative effect with IC₅₀ values of 4.5 ± 0.1 μM against A549 cells, 8.2 ± 0.5 μM against MDA-MB-231 cells, and 2.4 ± 0.3 μM against HepG2 cells, respectively.

从 Herpetospermum pedunculosum 的种子中分离出了两种以前未曾描述过的三萜类化合物，即 herpetosin A (1) 和 herpetosin B (2)，以及两种已知化合物，即葫芦素 B (3) 和二氢葫芦素 E (4)。通过分析核磁共振、HR-ESI-MS、X 射线数据和量子化学计算，阐明了它们的结构。化合物 1 以前所未有的 5/6/6/5 环系统的正葫芦烷三萜类骨架为特征。在所有分离物中，化合物 4 具有抗增殖作用，对 A549 细胞的 IC50 值分别为 4.5 ± 0.1 μM，对 MDA-MB-231 细胞的 IC50 值分别为 8.2 ± 0.5 μM，对 HepG2 细胞的 IC50 值分别为 2.4 ± 0.3 μM。

引用次数: 0

A new isoflavone from processed root barks of Paeonia suffruticosa and their procoagulant activity 从加工过的芍药根皮中提取的一种新异黄酮及其促凝血活性。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-02-01 DOI: 10.1080/14786419.2024.2425044

Shuo-Guo Li , Rui Yang , Mi-Mi Lu , Shu-Mei Wang , Jiang Meng

One new isoflavone, 6′-dihydroxy-2-methyl-2′-methoxyl-3′-acetylisoflavone (1) and six known compounds (2−7) were isolated from the processed root barks of Paeonia suffruticosa. The structures of these compounds were elucidated using UV, IR, NMR, and HR-ESI-MS data. Compound 1 represents the first example of naturally occurring 2-substituted isoflavone. Compounds 2−7 were isolated from the processed root barks of P. suffruticosa for the first time. In addition, all of the compounds were screened for their procoagulant activity. As a result, compounds 4, 6, and 7 showed significantly in vitro procoagulant activity.

从加工过的赤芍根皮中分离出了一种新的异黄酮--6'-二羟基-2-甲基-2'-甲氧基-3'-乙酰异黄酮（1）和六种已知化合物（2-7）。利用 UV、IR、NMR 和 HR-ESI-MS 数据阐明了这些化合物的结构。化合物 1 是天然存在的 2-取代异黄酮的第一个实例。化合物 2-7 是首次从经过加工的 P. suffruticosa 根皮中分离出来的。此外，还对所有化合物的促凝血活性进行了筛选。结果表明，化合物 4、6 和 7 具有显著的体外促凝血活性。

引用次数: 0

A new tyrosine derivative isolated from an actinomycin D producing mangrove rhizosphere soil-derived Streptomyces parvulus A-30 从产生放线菌素 D 的红树林根瘤土壤源链霉菌 A-30 中分离出一种新的酪氨酸衍生物。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-02-01 DOI: 10.1080/14786419.2024.2429114

Jingjing Ye , Juren Cen , Jingwan Wu , Zhenchang Wen , Hongjun Chen , Jing Xu

Chemical investigation of Streptomyces parvulus A-30, isolated from the mangrove plant Rhizophora apiculata rhizosphere soil resulted in the isolation of an optically new metabolite (R)-N-(5-amino-2-hydroxy-1-oxopentyl)-tyrosine (2), and seven known metabolites, including actinomycin D (1), (S)-2-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione (3), uracil (4), N-acetyltyramine (5), bis (2-ethylhexyl) phthalate (6), diorcinol (7), and 4-hydroxyphenethyl alcohol (8). Amongst, actinomycin D (1) was found to be a major component (1 g, 5.13%) and compound 3 was isolated as a natural product for the first time. Their structures were unambiguously elucidated on the basis of extensive spectroscopic data and comparison with the data of literature. All compounds isolated were subjected to immunosuppressive and cytotoxic activities evaluation. Compound 1 exhibited significant cytotoxicity against HepG-2 and Hela with IC₅₀ values of 2.62 ± 0.22 and 0.37 ± 0.88 µM, respectively, indicating it is principally responsible for the significant total cytotoxic effect of S. parvulus A-30.

通过对从红树植物根瘤菌土壤中分离出的链霉菌 A-30 进行化学研究，分离出了一种新的光学代谢物 (R)-N-(5-氨基-2-羟基-1-氧代戊基)-酪氨酸 (2)、以及七种已知代谢物，包括放线菌素 D (1)、(S)-2-甲基六氢吡咯并[1,2-a]吡嗪-1,4-二酮 (3)、尿嘧啶 (4)、N-乙酰基酪胺 (5)、邻苯二甲酸二（2-乙基己基）酯 (6)、二间苯二酚 (7) 和 4-羟基苯乙醇 (8)。其中，放线菌素 D（1）是主要成分（1 克，5.13%），化合物 3 则是首次作为天然产物分离出来。根据大量光谱数据以及与文献数据的比较，这些化合物的结构得到了明确的阐释。对所有分离出的化合物进行了免疫抑制和细胞毒性活性评估。化合物 1 对 HepG-2 和 Hela 具有显著的细胞毒性，其 IC50 值分别为 2.62 ± 0.22 和 0.37 ± 0.88 µM，表明它是 S. parvulus A-30 产生显著总细胞毒性效应的主要原因。

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引用次数: 0

Comparative study of phytochemical content, antioxidant, and anti-inflammatory properties of Merremia hirta Merr. mature plant and microgreen Merremia hirta Merr.成熟植株和小绿叶植物化学成分含量、抗氧化和抗炎特性的比较研究。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-02-01 DOI: 10.1080/14786419.2024.2425795

Dian Kurniati , Rahma Naifa Septiany , Elazmanawati Lembong , Indira Lanti Kayaputri , Gemilang Lara Utama

Merremia hirta Merr. is a plant belonging to the Convolvulaceae family, commonly used as a vegetable in Southeast Asia. The plant harbours diverse bioactive constituents, including polyphenols and flavonoids. Microgreens have gained popularity as a cultivation trend. They are referred to as superfoods due to their high bioactive content, which is estimated to be up to 10 times greater than mature plants. M. hirta Merr. microgreen and mature plant were investigated to determine their total phenol content using the Folin Ciocalteu method, total flavonoid content using AlCl₃, antioxidant activity using 2,2-diphenyl-1- picrylhydrazyl and ferric reducing antioxidant power, and anti-inflammatory activity by protein denaturation inhibition in vitro. Microgreen demonstrated greater total phenolic content, directly associated with its high antioxidant activity compared to mature plants. However, the mature stage of M. hirta Merr. remains superior in terms of overall flavonoid content and anti-inflammatory activity.

Merremia hirta Merr.是一种属于旋花科的植物，在东南亚通常被用作蔬菜。该植物含有多种生物活性成分，包括多酚和类黄酮。作为一种种植趋势，微型蔬菜越来越受欢迎。它们被称为超级食品，因为其生物活性含量很高，估计是成熟植物的 10 倍。研究人员用 Folin Ciocalteu 法检测了 M. hirta Merr. 微绿和成熟植株的总酚含量，用 AlCl3 法检测了总黄酮含量，用 2,2-二苯基-1-苦基肼和铁还原抗氧化力检测了抗氧化活性，用体外蛋白质变性抑制法检测了抗炎活性。与成熟植株相比，小绿叶表现出更高的总酚含量，这与其高抗氧化活性直接相关。不过，就总体类黄酮含量和抗炎活性而言，成熟期的 M. hirta Merr. 仍然更胜一筹。

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引用次数: 0

A butyrolactone derivative from marine-derived fungal strain Aspergillus terreus BTBU20211037 一种来自海洋源真菌菌株赤曲霉 BTBU20211037 的丁内酯衍生物。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-02-01 DOI: 10.1080/14786419.2024.2422515

Xinwan Zhang , Renming Jia , Jinpeng Yang , Zhijun Song , Xiuli Xu , Fuhang Song

The secondary metabolites of marine-derived fungal strain, Aspergillus terreus BTBU20211037, isolated from Qinhuangdao coast were investigated. Thirteen compounds were isolated and identified, including one new compound, butyrolactone J (1), and twelve known compounds, butyrolactone I (2), butyrolactone VI (3), aspernolide B (4), aspernolide A (5), 7’-hydroxybutyrolactone III (6), methyl asterrate (7), methyl dichloroasterrate (8), sulochrin (9), methyl 6-acetyl-4-methoxy-5,7,8-trihydroxynaphthalene-2-carboxylate (10), serantrypinone (11), alantrypinone (12), and territrem A (13). The structures of the compounds were elucidated by HRESIMS, NMR, and ECD analysis. Compounds 1, 10, and 13 showed inhibitory effects against Staphylococcus aureus ATCC 25923 with minimal inhibitory concentrations of 12.5, 25, and 100 μg/mL, respectively.

研究了从秦皇岛沿海分离的海洋源真菌菌株赤曲霉 BTBU20211037 的次级代谢产物。分离并鉴定了 13 个化合物，包括 1 个新化合物丁内酯 J (1)，12 个已知化合物丁内酯 I (2)、丁内酯 VI (3)、天冬内酯 B (4)、天冬内酯 A (5)、7'-羟基丁内酯 III (6)、紫菀酸甲酯 (7)、二氯紫菀酸甲酯 (8)、苏洛春内酯 (9)、6-乙酰基-4-甲氧基-5,7,8-三羟基萘-2-羧酸甲酯 (10)、丝兰内酯 (11)、丝兰内酯 (12) 和领土内酯 A (13)。这些化合物的结构通过 HRESIMS、NMR 和 ECD 分析得以阐明。化合物 1、10 和 13 对金黄色葡萄球菌 ATCC 25923 具有抑制作用，最小抑制浓度分别为 12.5、25 和 100 μg/mL。

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引用次数: 0

Analysis of the components of Cassia nomame and their antioxidant activity 决明子成分分析及其抗氧化活性。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-02-01 DOI: 10.1080/14786419.2024.2426060

Tetsuya Saito , Yuria Kurosu , Hajime Sato , Etsuko Katoh , Takahiro Hosoya

Cassia nomame, an annual herb belonging to the Leguminosae family, is traditionally consumed as tea in the form of dried whole herbs or beans. To deepen our understanding of the chemical constituents of C. nomame, we isolated 16 compounds, categorised as flavone derivatives (1–4), including a novel compound nomameflavone A (4), a chalcone derivative (5), an aurone derivative (6), a chromone derivative (7), a juglone derivative (8), anthraquinone derivatives (9–11), phenolic compounds (12–14), and sterol derivatives (15, 16). The structure of each compound was elucidated using NMR and MS. Compounds 2, 6, 7, 8, 12, 13, and 14 were successfully isolated from C. nomame for the first time. Furthermore, compounds 1, 3, 5, and 6 exhibited DPPH radical scavenging activities, and the bioactivity of 3 was discovered. The elucidation of the diverse chemical constituents of C. nomame underscores its potential functional ingredients.

决明子（Cassia nomame）是豆科一年生草本植物，传统上以干燥全草或全豆的形式作为茶叶饮用。为了加深对决明子化学成分的了解，我们分离了 16 种化合物，归类为黄酮衍生物（1-4），包括一种新型化合物决明黄酮 A（4）、一种查尔酮衍生物（5）、一种枳酮衍生物（6）、一种铬酮衍生物（7）、一种朱葛酮衍生物（8）、蒽醌衍生物（9-11）、酚类化合物（12-14）和甾醇衍生物（15, 16）。利用核磁共振和质谱对每种化合物的结构进行了阐明。化合物 2、6、7、8、12、13 和 14 是首次从 C. nomame 中成功分离出来。此外，化合物 1、3、5 和 6 具有清除 DPPH 自由基的活性，并发现了化合物 3 的生物活性。诺玛米中多种化学成分的阐明凸显了其潜在的功能成分。

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引用次数: 0

A new aglycone derivative from the saprophytic fungus Tubeufia rubra 腐生真菌红管菌的一个新的苷元衍生物。

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research

Pub Date : 2026-02-01 DOI: 10.1080/14786419.2024.2424391

Xin Li , Wen Zheng , Long Han , Zhang-Jiang He , Ji-Chuan Kang

A new aglycone derivative (1) and five known compounds (2–6) have been isolated from a saprophytic fungus Tubeufia rubra for the first time. Their structures and absolute configurations were determined by nuclear magnetic resonance, high resolution mass spectrometry data and electronic circular dichroism. The bioactivities of all compounds were evaluated by cell analysis. Compound 5 showed significant toxicity to human cancer A549 cells, and the IC₅₀ value was 32. 89 μg/mL. Compound 6 could reverse the multidrug resistance of A549/DDP cells, and the reversal value was 2.92. With the extension of the action time, the IC50 value of compound 6 decreased from 424.72 μg/mL at 24 h to 9.45 μg/mL at 72 h.

首次从红管真菌（Tubeufia rubra）中分离出了一种新的琼脂酮衍生物（1）和五种已知化合物（2-6）。通过核磁共振、高分辨率质谱数据和电子圆二色性测定了它们的结构和绝对构型。通过细胞分析评估了所有化合物的生物活性。化合物 5 对人类癌症 A549 细胞有明显毒性，其 IC50 值为 32.89 μg/mL。化合物 6 能逆转 A549/DDP 细胞的多药耐药性，逆转值为 2.92。随着作用时间的延长，化合物 6 的 IC50 值从 24 h 时的 424.72 μg/mL 降至 72 h 时的 9.45 μg/mL。

引用次数: 0

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