Pub Date : 2026-02-17DOI: 10.1038/s41587-025-02997-y
Mounia Stocker, Franziska Bächler
How do intellectual property rights and licensing structures influence access to CRISPR technologies? Could the right to science act as a complementary legal instrument to promote socially beneficial innovation?
{"title":"Democratizing CRISPR? Legal complexity, access and the right to science","authors":"Mounia Stocker, Franziska Bächler","doi":"10.1038/s41587-025-02997-y","DOIUrl":"10.1038/s41587-025-02997-y","url":null,"abstract":"How do intellectual property rights and licensing structures influence access to CRISPR technologies? Could the right to science act as a complementary legal instrument to promote socially beneficial innovation?","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 2","pages":"183-188"},"PeriodicalIF":41.7,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-17DOI: 10.1038/s41587-026-03021-7
{"title":"Biotech news from around the world","authors":"","doi":"10.1038/s41587-026-03021-7","DOIUrl":"10.1038/s41587-026-03021-7","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 2","pages":"168-168"},"PeriodicalIF":41.7,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-17DOI: 10.1038/s41587-026-03016-4
Cormac Sheridan
The European Commission is proposing sweeping new legislation aimed at reinvigorating Europe’s biotech sector.
欧盟委员会正在提议全面的新立法，旨在重振欧洲的生物技术部门。
{"title":"EU pushes for broad changes to biotech rules as China gains ground","authors":"Cormac Sheridan","doi":"10.1038/s41587-026-03016-4","DOIUrl":"10.1038/s41587-026-03016-4","url":null,"abstract":"The European Commission is proposing sweeping new legislation aimed at reinvigorating Europe’s biotech sector.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 2","pages":"167-167"},"PeriodicalIF":41.7,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-17DOI: 10.1038/s41587-026-03000-y
Mylena Maria Guedes de Almeida, Fabio Ynoe Moraes
A toolkit for students navigating decision fatigue in medical education.
一个帮助学生在医学教育中应对决策疲劳的工具包。
{"title":"Escaping analysis paralysis in medical training: from FRAZZLE to CALM","authors":"Mylena Maria Guedes de Almeida, Fabio Ynoe Moraes","doi":"10.1038/s41587-026-03000-y","DOIUrl":"10.1038/s41587-026-03000-y","url":null,"abstract":"A toolkit for students navigating decision fatigue in medical education.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"44 2","pages":"326-327"},"PeriodicalIF":41.7,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-16DOI: 10.1038/s41587-026-03001-x
Farzan Solimani, Masayuki Amagai, Catherine M. Bollard, Aimee S. Payne
{"title":"Clinical progress of engineered cellular immunotherapies for autoimmunity","authors":"Farzan Solimani, Masayuki Amagai, Catherine M. Bollard, Aimee S. Payne","doi":"10.1038/s41587-026-03001-x","DOIUrl":"https://doi.org/10.1038/s41587-026-03001-x","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"4 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146205341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-10DOI: 10.1038/s41587-025-02619-7
Guorui Chen, Tzuchun Chung, Zeyang Liu, Yan-Ruide Li, Kamryn Scott, Xun Zhao, Jarod Carol, Soomin Park, Yihao Zhou, Wi Jin Kim, Xinyang Ge, Geoffrey P. Colby, Song Li, Jun Chen
Conventional approaches for vascular graft stenosis diagnostics, including X-ray angiography, magnetic resonance imaging and Doppler ultrasound, although highly accurate, are cumbersome, used intermittently and often do not detect stenosis early enough, leading to diagnosis only after substantial narrowing. Here we report a magnetoelastic vascular graft (MVG) for post-implantation stenosis diagnosis that is hemodynamics-driven, biocompatible and waterproof. It enables wireless, real-time and continuous diagnosis of stenosis by converting arterial hemodynamics into high-fidelity electrical signals. The MVGs were scalably manufactured with customizable diameters and tested in vivo in the femoral arteries of rats and swine through microsurgical anastomosis. The anastomosed MVGs restored blood flow and identified the location and severity of induced stenosis through artificial intelligence-assisted analysis. Furthermore, a 4-month in vivo study in rats verified the stability and biocompatibility of the MVGs in the host, with no evident signs of an adverse immune response. The MVG is expected to advance existing vascular graft solutions and improve vascular disease management.
{"title":"Hemodynamics-driven magnetoelastic vascular grafts for stenosis diagnosis","authors":"Guorui Chen, Tzuchun Chung, Zeyang Liu, Yan-Ruide Li, Kamryn Scott, Xun Zhao, Jarod Carol, Soomin Park, Yihao Zhou, Wi Jin Kim, Xinyang Ge, Geoffrey P. Colby, Song Li, Jun Chen","doi":"10.1038/s41587-025-02619-7","DOIUrl":"https://doi.org/10.1038/s41587-025-02619-7","url":null,"abstract":"Conventional approaches for vascular graft stenosis diagnostics, including X-ray angiography, magnetic resonance imaging and Doppler ultrasound, although highly accurate, are cumbersome, used intermittently and often do not detect stenosis early enough, leading to diagnosis only after substantial narrowing. Here we report a magnetoelastic vascular graft (MVG) for post-implantation stenosis diagnosis that is hemodynamics-driven, biocompatible and waterproof. It enables wireless, real-time and continuous diagnosis of stenosis by converting arterial hemodynamics into high-fidelity electrical signals. The MVGs were scalably manufactured with customizable diameters and tested in vivo in the femoral arteries of rats and swine through microsurgical anastomosis. The anastomosed MVGs restored blood flow and identified the location and severity of induced stenosis through artificial intelligence-assisted analysis. Furthermore, a 4-month in vivo study in rats verified the stability and biocompatibility of the MVGs in the host, with no evident signs of an adverse immune response. The MVG is expected to advance existing vascular graft solutions and improve vascular disease management.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"88 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146152334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-10DOI: 10.1038/s41587-026-03004-8
Sebastian Tiesmeyer, Niklas Müller-Bötticher, Alexander Malt, Leyao Ma, Sergio Marco-Salas, Paul Kiessling, Paul Horn, Adrien Guillot, Louis B. Kuemmerle, Frank Tacke, Fabian J. Theis, Christoph Kuppe, Mats Nilsson, Roland Eils, Brian Long, Naveed Ishaque
Imaging-based spatially resolved transcriptomics can localize transcripts within tissue sections in three dimensions. However, cell segmentation, which assigns transcripts to cells, is usually performed in two dimensions and spatial doublets in the vertical dimension result in segmented cells containing transcripts originating from multiple cell types. Here we present a computational tool called ovrlpy that identifies overlapping cells, tissue folds and inaccurate cell segmentation by analyzing transcript localization in three dimensions.
{"title":"Identifying 3D signal overlaps in spatial transcriptomics data with ovrlpy","authors":"Sebastian Tiesmeyer, Niklas Müller-Bötticher, Alexander Malt, Leyao Ma, Sergio Marco-Salas, Paul Kiessling, Paul Horn, Adrien Guillot, Louis B. Kuemmerle, Frank Tacke, Fabian J. Theis, Christoph Kuppe, Mats Nilsson, Roland Eils, Brian Long, Naveed Ishaque","doi":"10.1038/s41587-026-03004-8","DOIUrl":"https://doi.org/10.1038/s41587-026-03004-8","url":null,"abstract":"Imaging-based spatially resolved transcriptomics can localize transcripts within tissue sections in three dimensions. However, cell segmentation, which assigns transcripts to cells, is usually performed in two dimensions and spatial doublets in the vertical dimension result in segmented cells containing transcripts originating from multiple cell types. Here we present a computational tool called ovrlpy that identifies overlapping cells, tissue folds and inaccurate cell segmentation by analyzing transcript localization in three dimensions.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"7 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146152333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-10DOI: 10.1038/s41587-026-03011-9
Emma Warrner, Aria Zheyuan Huang, Alex J Hughes
Developmentally inspired kidney tissues derived from stem cells hold promise for future renal replacement tissue, but clinical translation is limited by variability in outcomes, absence of cell types, lack of functional maturity and implausible scalability. Overcoming these may benefit from tissue engineering strategies that leverage processes for tissue construction that the embryonic kidney uses to achieve its diverse and parallelized functions. We present a 'developmental engineering' strategy in which spatial and temporal cues inspired by in vivo development guide multiscale structure formation in vitro. We highlight emerging tools in synthetic biology, spatial patterning and control over tissue microenvironments that can set initial and boundary conditions to instigate and guide the development of a desired 'motif'. We then present a vision for scalable developmental engineering by guiding and daisy-chaining tissue motifs, bridging discontinuities in self-organization via direct assembly. Although we articulate a blueprint for developmental engineering of translationally viable renal replacement tissues, the strategy is also applicable to other solid organs.
{"title":"Developmentally inspired synthetic kidney engineering.","authors":"Emma Warrner, Aria Zheyuan Huang, Alex J Hughes","doi":"10.1038/s41587-026-03011-9","DOIUrl":"https://doi.org/10.1038/s41587-026-03011-9","url":null,"abstract":"<p><p>Developmentally inspired kidney tissues derived from stem cells hold promise for future renal replacement tissue, but clinical translation is limited by variability in outcomes, absence of cell types, lack of functional maturity and implausible scalability. Overcoming these may benefit from tissue engineering strategies that leverage processes for tissue construction that the embryonic kidney uses to achieve its diverse and parallelized functions. We present a 'developmental engineering' strategy in which spatial and temporal cues inspired by in vivo development guide multiscale structure formation in vitro. We highlight emerging tools in synthetic biology, spatial patterning and control over tissue microenvironments that can set initial and boundary conditions to instigate and guide the development of a desired 'motif'. We then present a vision for scalable developmental engineering by guiding and daisy-chaining tissue motifs, bridging discontinuities in self-organization via direct assembly. Although we articulate a blueprint for developmental engineering of translationally viable renal replacement tissues, the strategy is also applicable to other solid organs.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":" ","pages":""},"PeriodicalIF":41.7,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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