Pub Date : 2023-12-11DOI: 10.1038/s41587-023-02051-9
Luiza Braga, Renato Lopes, Luiz Alves, Fabio Mota
A review of the emerging patent landscape can assist key actors in making informed strategic decisions about AI applications in oncology.
对新出现的专利情况进行审查，有助于关键参与者就人工智能在肿瘤学中的应用做出明智的战略决策。
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Pub Date : 2023-12-11DOI: 10.1038/s41587-023-02052-8
Recent patents relating to methods of characterizing metagenomic samples and analyzing and processing metagenomic data.
有关表征元基因组样本以及分析和处理元基因组数据的方法的最新专利。
{"title":"Metagenomics","authors":"","doi":"10.1038/s41587-023-02052-8","DOIUrl":"10.1038/s41587-023-02052-8","url":null,"abstract":"Recent patents relating to methods of characterizing metagenomic samples and analyzing and processing metagenomic data.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"41 12","pages":"1688-1688"},"PeriodicalIF":46.9,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138565028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.1038/s41587-023-02069-z
Anne Doerr
{"title":"Yeast with a half-synthetic genome","authors":"Anne Doerr","doi":"10.1038/s41587-023-02069-z","DOIUrl":"10.1038/s41587-023-02069-z","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"41 12","pages":"1689-1689"},"PeriodicalIF":46.9,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138564972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.1038/s41587-023-02070-6
{"title":"First in vivo base editing lowers cholesterol","authors":"","doi":"10.1038/s41587-023-02070-6","DOIUrl":"10.1038/s41587-023-02070-6","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"41 12","pages":"1665-1665"},"PeriodicalIF":46.9,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138571114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.1038/s41587-023-02018-w
Esther Ivorra-Molla, Dipayan Akhuli, Martin B. L. McAndrew, William Scott, Lokesh Kumar, Saravanan Palani, Masanori Mishima, Allister Crow, Mohan K. Balasubramanian
StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite favorable fluorescence properties, use of StayGold as a fluorescent tag is limited because it forms a natural dimer. Here we report the 1.6 Å structure of StayGold and generate a derivative, mStayGold, that retains the brightness and photostability of the original protein while being fully monomeric. The bright, photostable fluorescent protein StayGold is converted into a monomer.
StayGold 是一种异常明亮和稳定的荧光蛋白，具有很强的抗光漂白能力。尽管具有良好的荧光特性，但由于 StayGold 会形成天然二聚体，因此将其用作荧光标记受到了限制。在这里，我们报告了 StayGold 的 1.6 Å 结构，并生成了一种衍生物 mStayGold，它既保留了原始蛋白质的亮度和光稳定性，又是完全的单体。
{"title":"A monomeric StayGold fluorescent protein","authors":"Esther Ivorra-Molla, Dipayan Akhuli, Martin B. L. McAndrew, William Scott, Lokesh Kumar, Saravanan Palani, Masanori Mishima, Allister Crow, Mohan K. Balasubramanian","doi":"10.1038/s41587-023-02018-w","DOIUrl":"10.1038/s41587-023-02018-w","url":null,"abstract":"StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite favorable fluorescence properties, use of StayGold as a fluorescent tag is limited because it forms a natural dimer. Here we report the 1.6 Å structure of StayGold and generate a derivative, mStayGold, that retains the brightness and photostability of the original protein while being fully monomeric. The bright, photostable fluorescent protein StayGold is converted into a monomer.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"42 9","pages":"1368-1371"},"PeriodicalIF":33.1,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41587-023-02018-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138571435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.1038/s41587-023-02058-2
Recent moves of note in and around the biotech and pharma industries.
近期生物技术和制药行业及其周边值得关注的动向。
{"title":"People","authors":"","doi":"10.1038/s41587-023-02058-2","DOIUrl":"10.1038/s41587-023-02058-2","url":null,"abstract":"Recent moves of note in and around the biotech and pharma industries.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"41 12","pages":"1834-1834"},"PeriodicalIF":46.9,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138564970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-11DOI: 10.1038/s41587-023-02056-4
Julie Foncy, Marta Kwapisz, Martine Knibiehler, Julie Batut
A workshop based on collective intelligence lays the foundations of mentor–mentee interactions by providing tools to build a valuable relationship.
基于集体智慧的研讨会通过提供建立有价值关系的工具，为指导者与被指导者之间的互动奠定了基础。
{"title":"Collectively building a mentor–mentee relationship through a one-day workshop","authors":"Julie Foncy, Marta Kwapisz, Martine Knibiehler, Julie Batut","doi":"10.1038/s41587-023-02056-4","DOIUrl":"10.1038/s41587-023-02056-4","url":null,"abstract":"A workshop based on collective intelligence lays the foundations of mentor–mentee interactions by providing tools to build a valuable relationship.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"41 12","pages":"1829-1833"},"PeriodicalIF":46.9,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138564953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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