Pub Date : 2025-03-17DOI: 10.1038/s41587-025-02605-z
Emily Waltz
{"title":"Trapped in a lake, founder spots a bioplastic opportunity","authors":"Emily Waltz","doi":"10.1038/s41587-025-02605-z","DOIUrl":"10.1038/s41587-025-02605-z","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 3","pages":"293-293"},"PeriodicalIF":33.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41587-025-02605-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1038/s41587-025-02604-0
Iris Marchal
{"title":"Fluorescence imaging of RNA and protein in deep tissue","authors":"Iris Marchal","doi":"10.1038/s41587-025-02604-0","DOIUrl":"10.1038/s41587-025-02604-0","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 3","pages":"301-301"},"PeriodicalIF":33.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1038/s41587-025-02609-9
{"title":"Tough times for CRISPR startups","authors":"","doi":"10.1038/s41587-025-02609-9","DOIUrl":"10.1038/s41587-025-02609-9","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 3","pages":"292-292"},"PeriodicalIF":33.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1038/s41587-025-02584-1
Dennis J. Hazelett
{"title":"An open letter to graduate students and other procrastinators: it’s time to write","authors":"Dennis J. Hazelett","doi":"10.1038/s41587-025-02584-1","DOIUrl":"10.1038/s41587-025-02584-1","url":null,"abstract":"","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 3","pages":"447-450"},"PeriodicalIF":33.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41587-025-02584-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1038/s41587-025-02588-x
Recent moves of note in and around the biotech and pharma industries.
{"title":"People","authors":"","doi":"10.1038/s41587-025-02588-x","DOIUrl":"10.1038/s41587-025-02588-x","url":null,"abstract":"Recent moves of note in and around the biotech and pharma industries.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 3","pages":"452-452"},"PeriodicalIF":33.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1038/s41587-025-02587-y
Chunzhe Lu, Andrea Bonini, Jakob H. Viel, Giovanni Maglia
Over the past three decades, biological nanopore sequencing has grown from a research curiosity to a mature technology to sequence nucleic acids at the single-molecule level. Now, recent achievements suggest that nanopores might be able to sequence proteins soon. In this Perspective, we analyze the different approaches that have been proposed to measure proteins and peptides using nanopores. We predict that, more likely than not, nanopores will be capable of identifying full-length proteins at the single-molecule level and with single-amino acid resolution, paving the way to single-molecule protein sequencing. This would allow several applications in proteomics that are at present challenging, including measuring the heterogeneity of post-translational modifications, quantifying low-abundance proteins and characterizing protein splicing. Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing
{"title":"Toward single-molecule protein sequencing using nanopores","authors":"Chunzhe Lu, Andrea Bonini, Jakob H. Viel, Giovanni Maglia","doi":"10.1038/s41587-025-02587-y","DOIUrl":"10.1038/s41587-025-02587-y","url":null,"abstract":"Over the past three decades, biological nanopore sequencing has grown from a research curiosity to a mature technology to sequence nucleic acids at the single-molecule level. Now, recent achievements suggest that nanopores might be able to sequence proteins soon. In this Perspective, we analyze the different approaches that have been proposed to measure proteins and peptides using nanopores. We predict that, more likely than not, nanopores will be capable of identifying full-length proteins at the single-molecule level and with single-amino acid resolution, paving the way to single-molecule protein sequencing. This would allow several applications in proteomics that are at present challenging, including measuring the heterogeneity of post-translational modifications, quantifying low-abundance proteins and characterizing protein splicing. Maglia and colleagues discuss advances in nanopore technology en route to single-molecule protein sequencing","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 3","pages":"312-322"},"PeriodicalIF":33.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-05DOI: 10.1038/s41587-025-02594-z
Jiacheng Gu, Abhishek Iyer, Ben Wesley, Angelo Taglialatela, Giuseppe Leuzzi, Sho Hangai, Aubrianna Decker, Ruoyu Gu, Naomi Klickstein, Yuanlong Shuai, Kristina Jankovic, Lucy Parker-Burns, Yinuo Jin, Jia Yi Zhang, Justin Hong, Xiang Niu, Jonathon A. Costa, Mikael G. Pezet, Jacqueline Chou, Cao ‘Claire’ Chen, Margaret Paiva, Hans-Willem Snoeck, Dan A. Landau, Elham Azizi, Edmond M. Chan, Alberto Ciccia, Jellert T. Gaublomme
Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-024-02386-x, published online 7 October 2024.
{"title":"Author Correction: Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap","authors":"Jiacheng Gu, Abhishek Iyer, Ben Wesley, Angelo Taglialatela, Giuseppe Leuzzi, Sho Hangai, Aubrianna Decker, Ruoyu Gu, Naomi Klickstein, Yuanlong Shuai, Kristina Jankovic, Lucy Parker-Burns, Yinuo Jin, Jia Yi Zhang, Justin Hong, Xiang Niu, Jonathon A. Costa, Mikael G. Pezet, Jacqueline Chou, Cao ‘Claire’ Chen, Margaret Paiva, Hans-Willem Snoeck, Dan A. Landau, Elham Azizi, Edmond M. Chan, Alberto Ciccia, Jellert T. Gaublomme","doi":"10.1038/s41587-025-02594-z","DOIUrl":"https://doi.org/10.1038/s41587-025-02594-z","url":null,"abstract":"<p>Correction to: <i>Nature Biotechnology</i> https://doi.org/10.1038/s41587-024-02386-x, published online 7 October 2024.</p>","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"1 1","pages":""},"PeriodicalIF":46.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-05DOI: 10.1038/s41587-025-02603-1
A recent study found high amounts of microplastics in the human brain. This could spur funding and technological advances for plastic degradation.
{"title":"Bite-sized solutions","authors":"","doi":"10.1038/s41587-025-02603-1","DOIUrl":"10.1038/s41587-025-02603-1","url":null,"abstract":"A recent study found high amounts of microplastics in the human brain. This could spur funding and technological advances for plastic degradation.","PeriodicalId":19084,"journal":{"name":"Nature biotechnology","volume":"43 3","pages":"285-286"},"PeriodicalIF":33.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41587-025-02603-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：