Pub Date : 2019-09-27DOI: 10.26641/1997-9665.2019.3.22-25
V. Vovk, U. Omelyash
{"title":"Thyroid papillary carcinoma and hashimoto's autoimmune thyroiditis in patients operated on thyroid diseases in the precarpathian endemic goiter region.","authors":"V. Vovk, U. Omelyash","doi":"10.26641/1997-9665.2019.3.22-25","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.22-25","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73575862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.26641/1997-9665.2019.3.170-175
M. Shchur, O. Zhurakivska
{"title":"Morphological characteristics of the visual cortex in experimental diabetes mellitus.","authors":"M. Shchur, O. Zhurakivska","doi":"10.26641/1997-9665.2019.3.170-175","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.170-175","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79368484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.26641/1997-9665.2019.3.120-125
O. Savchenko
{"title":"Histological and immunohistochemical features of the ovarian malignant tumors with different histogenesis.","authors":"O. Savchenko","doi":"10.26641/1997-9665.2019.3.120-125","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.120-125","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89497626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.26641/1997-9665.2019.3.133-137
V. Fik, I. Chelpanova, E. V. Paltоv
{"title":"Morphometric studies of periodontal structures during opioid exposure at the end of six and eight weeks.","authors":"V. Fik, I. Chelpanova, E. V. Paltоv","doi":"10.26641/1997-9665.2019.3.133-137","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.133-137","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89583290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.26641/1997-9665.2019.3.86-92
I. I. Okrim
{"title":"Anatomic variability of the intercostal neurovascular bundle in human fetuses.","authors":"I. I. Okrim","doi":"10.26641/1997-9665.2019.3.86-92","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.86-92","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74682676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.26641/1997-9665.2019.3.7-21
O. O. Oshivalova, L. D. Kaluzhna, I. Shponka, O. Poslavska
Background. Skin damage by type of actinic keratosis (AK) and squamous cell carcinoma in situ (SCCis) are considered to be precursors to cSCC. A common theory about the gradual transition from normal skin to AK and cSCC. Some scientists believe that AK is the same cancer as cSCC. Objective. To investigate the complex of histological, immunohistochemical characteristics of observations of areas of AK, SCCis and cSCC with the purpose of further improvement of preventive measures. Methods. Bioassays of 20 (50%) patients with AK were used, 10 (25%) were SCCis, and 10 (25%) were CCSCs. The levels of epidermal dysplasia (KIN) have been determined. Light microscopy was performed with a Zeiss Primo Star light microscope using × 10, × 20, × 40 lenses, and a morphometric examination was performed using a Zeiss Primo Star microscope camera - Axiocam ERC 5s with ZEN 2 blue edition licensed software. Statistical processing of the material was performed using Microsoft Office Exel software. Results. When comparing the expression levels of the investigated markers in the AK foci, the "cancer field" and the SCC, a significant difference occurred only in the expression level of pcna (p = 0.014 and p = 0.011). With the increase in the level of dysplasia of the epidermis there is a tendency to increase the level of bcl-2 (R2 = 0.815), p53 (R2 = 0.744) vegf mean (R2 = 0.680). Trends in increasing pcna and vegf levels against the background of decreasing levels of bcl-2, p53, and p27 in the SCC zone (R2 = 1.0). Conclusion. The study confirms the scientific opinion about the closeness of immunohistochemical changes in the focus of AK and cSCC.
{"title":"Immunohistochemical features of actinic keratosis.","authors":"O. O. Oshivalova, L. D. Kaluzhna, I. Shponka, O. Poslavska","doi":"10.26641/1997-9665.2019.3.7-21","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.7-21","url":null,"abstract":"Background. Skin damage by type of actinic keratosis (AK) and squamous cell carcinoma in situ (SCCis) are considered to be precursors to cSCC. A common theory about the gradual transition from normal skin to AK and cSCC. Some scientists believe that AK is the same cancer as cSCC. Objective. To investigate the complex of histological, immunohistochemical characteristics of observations of areas of AK, SCCis and cSCC with the purpose of further improvement of preventive measures. Methods. Bioassays of 20 (50%) patients with AK were used, 10 (25%) were SCCis, and 10 (25%) were CCSCs. The levels of epidermal dysplasia (KIN) have been determined. Light microscopy was performed with a Zeiss Primo Star light microscope using × 10, × 20, × 40 lenses, and a morphometric examination was performed using a Zeiss Primo Star microscope camera - Axiocam ERC 5s with ZEN 2 blue edition licensed software. Statistical processing of the material was performed using Microsoft Office Exel software. Results. When comparing the expression levels of the investigated markers in the AK foci, the \"cancer field\" and the SCC, a significant difference occurred only in the expression level of pcna (p = 0.014 and p = 0.011). With the increase in the level of dysplasia of the epidermis there is a tendency to increase the level of bcl-2 (R2 = 0.815), p53 (R2 = 0.744) vegf mean (R2 = 0.680). Trends in increasing pcna and vegf levels against the background of decreasing levels of bcl-2, p53, and p27 in the SCC zone (R2 = 1.0). Conclusion. The study confirms the scientific opinion about the closeness of immunohistochemical changes in the focus of AK and cSCC.","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91169646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.26641/1997-9665.2019.3.115-119
O. M. Rudiak
{"title":"Differential diagnosis of pathomorphological changes in the lungs of pregnant children in certain components of the metabolic syndrome of the mother.","authors":"O. M. Rudiak","doi":"10.26641/1997-9665.2019.3.115-119","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.115-119","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87805791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.26641/1997-9665.2019.3.99-106
О. Poslavska, I. Shponka
Background. Approximately 2/3 of cancers of unknown primary origin (CUP) are adenocarcinomas with mucin production, the formation of gland-like structures and immunohistochemistry results that can determine the histological subtype, but cannot determine the exact primary place of origin. The remaining 1/3 of CUP is a mixture of non-adenocarcinomas, including squamous cell carcinomas, neuroendocrine carcinomas, small-cell and large-cell undifferentiated carcinomas. Objective. In such cases, molecular profile identification and gene sequencing may be a promising approach to the classification and direct treatment of CUP. Methods. A retrospective analysis of biopsy or postoperative material of 61 patients (34 women and 27 men) aged 26 to 74 years (mean 53.4 ± 11.42; median 52) with an initial diagnosis of CUP was performed. Immunohistochemical studies were carried out according to the protocols of TermoScientific (USA) with antibodies to p16INK4a and HER2/neu. Fluorescence in situ hybridization was performed according to the protocol of ZytoVision GmbH (Germany). Changes in the ERBB2 and CDKN2A genes were evaluated for gene amplification and deletion of the 9p21 locus, respectively, with double-labeled DNA probes. Results. Of the 61 studied cases of CUP, p16 expression was positive in 31 cases (51%), the basis for which was 9 homozygous and 19 heterozygous 9p21 deletions, which were found in all but one of the studied CUP phenotypes. HER2 / neu expression was positive (2 + / 3 +) in 15 of 61 (25%) CUP, but only in 9 of them had actual amplification of the ERBB2 gene on FISH in 5 phenotypes. Conclusion . The reduced number of phenotypes with amplification of the ERBB2 gene makes it more specific for the differential diagnosis of CUP, compared with the deletion of 9p21 (p16 / CDKN2A), which is likely to be universal in acquiring an aggressive course of carcinomas of various localizations.
{"title":"Features of the expression of prognostic markers p16, Her2 / new and changes in the corresponding genes in individual phenotypes of cancers of unknown primary origin.","authors":"О. Poslavska, I. Shponka","doi":"10.26641/1997-9665.2019.3.99-106","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.99-106","url":null,"abstract":"Background. Approximately 2/3 of cancers of unknown primary origin (CUP) are adenocarcinomas with mucin production, the formation of gland-like structures and immunohistochemistry results that can determine the histological subtype, but cannot determine the exact primary place of origin. The remaining 1/3 of CUP is a mixture of non-adenocarcinomas, including squamous cell carcinomas, neuroendocrine carcinomas, small-cell and large-cell undifferentiated carcinomas. Objective. In such cases, molecular profile identification and gene sequencing may be a promising approach to the classification and direct treatment of CUP. Methods. A retrospective analysis of biopsy or postoperative material of 61 patients (34 women and 27 men) aged 26 to 74 years (mean 53.4 ± 11.42; median 52) with an initial diagnosis of CUP was performed. Immunohistochemical studies were carried out according to the protocols of TermoScientific (USA) with antibodies to p16INK4a and HER2/neu. Fluorescence in situ hybridization was performed according to the protocol of ZytoVision GmbH (Germany). Changes in the ERBB2 and CDKN2A genes were evaluated for gene amplification and deletion of the 9p21 locus, respectively, with double-labeled DNA probes. Results. Of the 61 studied cases of CUP, p16 expression was positive in 31 cases (51%), the basis for which was 9 homozygous and 19 heterozygous 9p21 deletions, which were found in all but one of the studied CUP phenotypes. HER2 / neu expression was positive (2 + / 3 +) in 15 of 61 (25%) CUP, but only in 9 of them had actual amplification of the ERBB2 gene on FISH in 5 phenotypes. Conclusion . The reduced number of phenotypes with amplification of the ERBB2 gene makes it more specific for the differential diagnosis of CUP, compared with the deletion of 9p21 (p16 / CDKN2A), which is likely to be universal in acquiring an aggressive course of carcinomas of various localizations.","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84383117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.26641/1997-9665.2019.3.93-98
K. Pobelensky, N. V. Kolot, E. Protsenko, V. Padalko, G. Bozhok, E. Legach, О. N. Pobelensky
{"title":"Dynamics of morphological parameters of the thyroid gland in hypertensive SHR rats upon administration of propylthiouracil.","authors":"K. Pobelensky, N. V. Kolot, E. Protsenko, V. Padalko, G. Bozhok, E. Legach, О. N. Pobelensky","doi":"10.26641/1997-9665.2019.3.93-98","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.93-98","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89852845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-27DOI: 10.26641/1997-9665.2019.3.26-31
N. Hryntsova, A. M. Romanіyk, V. Bumeister
{"title":"Morphological rearrangements of the rat’s adrenal cortex under conditions of prolonged exposure to heavy metal salts and non-hormonal correction.","authors":"N. Hryntsova, A. M. Romanіyk, V. Bumeister","doi":"10.26641/1997-9665.2019.3.26-31","DOIUrl":"https://doi.org/10.26641/1997-9665.2019.3.26-31","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80949546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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