Pub Date : 2020-06-19DOI: 10.26641/1997-9665.2020.2.7-16
A. Abaturov, V. Babуch, N. Bondarenko, O. Bondarenko, A. Lievykh, I. Tverdokhlib
{"title":"Morphological evaluation of the effects of ursodeoxycholic acid on muscular layer of the gallbladder wall of the mice","authors":"A. Abaturov, V. Babуch, N. Bondarenko, O. Bondarenko, A. Lievykh, I. Tverdokhlib","doi":"10.26641/1997-9665.2020.2.7-16","DOIUrl":"https://doi.org/10.26641/1997-9665.2020.2.7-16","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85017213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-06-19DOI: 10.26641/1997-9665.2020.2.67
Editorial office Of journal "Morphologia"
{"title":"IELTS Academic Study Guide 2020-2021: IELTS Academic Exam Prep Book with Audio and Practice Test Questions for the International English Language Testing System Exam Author(s): Trivium English Exam Prep Team Publication Date: 25 Nov 2019","authors":"Editorial office Of journal \"Morphologia\"","doi":"10.26641/1997-9665.2020.2.67","DOIUrl":"https://doi.org/10.26641/1997-9665.2020.2.67","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83693588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-19DOI: 10.26641/1997-9665.2020.1.23-34
D. Zinenko, I. Tverdokhlib
Background . The development of acute pancreatitis is not limited to isolated damage to the pancreas. After creating models of acute pancreatitis using various substances that enhance the secretion of the gland, have a toxic or local activating effect, the researchers showed their dose-dependent effect. The question of the reaction of the hepatic microcirculation system during the development of acute pancreatitis, as well as their pathogenetic significance in the development of pathomorphological changes in the pancreas and liver in most aspects remains open. Objective . The purpose of the current study was to define the role of the hepatic mircocirculation in development of ultrastructural parenchymatous-stromal changes of the pancreas and liver in a model of acute pancreatitis using different doses of sodium taurocholate. M ethods. The variants of acute pancreatitis model were used with injection 50 mkl 1%, 2,5% and 5% solutions of sodium taurocholat into rat pancreatic duct. The morphological research of pancreas and liver were carried out in 1, 4, 8, 12, 24, 48 and 72 hours after initiation of inflammation. Results . The visible reaction of hepatic mircocirculation in the experimental model of acute pancreatitis was depended on character of pathomorphological changes in pancreas. This reaction demonstrated the phase character including: 1) activation of hepatic circulation, first of all in portal component, against a background of pancreatic enzyme toxemia; 2) development of inflammatory, dystrophic, destructive and necrotic changes in hepatic parenchyme together with mircocirculation disorders against a background of pancreatic necrotic toxemia; 3) recovery and adaptation or decompensation processes in mircocirculation system of liver and hepatic parenchyme depending on the degree of pancreatogenic toxemia|. Conclusion. Within 72 hours of the experiment, at the lowest and middling doses of sodium taurocholate, in the context of reduction of acute pancreatitis, there is a gradual renovation of the structure of the microvessels and normalization of the microcirculation of the liver. In the maximum doses sodium taurocholate (5% solution) cause degradation of the liver microvessels with the progression of hemorrhages, slit red blood cells and platelet aggregation, which causes blockage of the microcirculation and the development of necrotic changes in the hepatic parenchyma.
{"title":"Ultrastructural characteristics of the hemomicrocirculatory bed and parenchymatous-stromal elements of the pancreas and liver in a model of acute pancreatitis using different doses of sodium taurocholate.","authors":"D. Zinenko, I. Tverdokhlib","doi":"10.26641/1997-9665.2020.1.23-34","DOIUrl":"https://doi.org/10.26641/1997-9665.2020.1.23-34","url":null,"abstract":"Background . The development of acute pancreatitis is not limited to isolated damage to the pancreas. After creating models of acute pancreatitis using various substances that enhance the secretion of the gland, have a toxic or local activating effect, the researchers showed their dose-dependent effect. The question of the reaction of the hepatic microcirculation system during the development of acute pancreatitis, as well as their pathogenetic significance in the development of pathomorphological changes in the pancreas and liver in most aspects remains open. Objective . The purpose of the current study was to define the role of the hepatic mircocirculation in development of ultrastructural parenchymatous-stromal changes of the pancreas and liver in a model of acute pancreatitis using different doses of sodium taurocholate. M ethods. The variants of acute pancreatitis model were used with injection 50 mkl 1%, 2,5% and 5% solutions of sodium taurocholat into rat pancreatic duct. The morphological research of pancreas and liver were carried out in 1, 4, 8, 12, 24, 48 and 72 hours after initiation of inflammation. Results . The visible reaction of hepatic mircocirculation in the experimental model of acute pancreatitis was depended on character of pathomorphological changes in pancreas. This reaction demonstrated the phase character including: 1) activation of hepatic circulation, first of all in portal component, against a background of pancreatic enzyme toxemia; 2) development of inflammatory, dystrophic, destructive and necrotic changes in hepatic parenchyme together with mircocirculation disorders against a background of pancreatic necrotic toxemia; 3) recovery and adaptation or decompensation processes in mircocirculation system of liver and hepatic parenchyme depending on the degree of pancreatogenic toxemia|. Conclusion. Within 72 hours of the experiment, at the lowest and middling doses of sodium taurocholate, in the context of reduction of acute pancreatitis, there is a gradual renovation of the structure of the microvessels and normalization of the microcirculation of the liver. In the maximum doses sodium taurocholate (5% solution) cause degradation of the liver microvessels with the progression of hemorrhages, slit red blood cells and platelet aggregation, which causes blockage of the microcirculation and the development of necrotic changes in the hepatic parenchyma.","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85632186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-19DOI: 10.26641/1997-9665.2020.1.71-73
Editorial office Of journal "Morphologia"
{"title":"Third All-Ukrainian Scientific and Practical Conference with International Participation “Theory and Practice of Modern Morphology” (Dnipro, 2019)","authors":"Editorial office Of journal \"Morphologia\"","doi":"10.26641/1997-9665.2020.1.71-73","DOIUrl":"https://doi.org/10.26641/1997-9665.2020.1.71-73","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83181002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-19DOI: 10.26641/1997-9665.2020.1.67-69
Editorial office Of journal "Morphologia"
{"title":"First Aid for the USMLE® Step 1 2020 Thirtieth edition Authors: Tao Le, Vikas Bhushan","authors":"Editorial office Of journal \"Morphologia\"","doi":"10.26641/1997-9665.2020.1.67-69","DOIUrl":"https://doi.org/10.26641/1997-9665.2020.1.67-69","url":null,"abstract":"","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90673965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-19DOI: 10.26641/1997-9665.2020.1.35-41
D. Kuliesh, N. Galatenko, R. Rozhnova, V. Gritsenko, A. Bogdan, V. B. Volkov
Background. High levels of musculoskeletal injuries, pathologies and various diseases of bone tissue encourage researchers around the world to actively seek out new and improve existing implant materials for high-quality reconstructive and restorative operations on bone tissue. Objective. Histological examination and evaluation of biocompatibility of 3-D printed implants after implantation in experimental animals. Methods. 3-D printed materials were implanted into the white laboratory rats Wistar for 1, 4, and 12 weeks. The cellular reactions of the organism and possible changes in the structure of the test specimens after implantation were studied by light microscopy by histological micropreparation analysis. Results. Histological examination was performed and the nature and dynamics of cellular responses after implantation of 3-D printed materials were evaluated. Conclusion. It was found that cellular migration and germination of connective tissue tendons deep into the implants due to the porous structure of 3-D printed material based on ceramics, resulted in partial degradation, which slightly increased the intensity of cellular reactions at all study periods. It was found that the intensity of cellular reactions was minimal in the early stages of the study around polymer-based 3-D printed material, but 12 weeks after implantation, cellular responses were increased. It is shown that implantation of 3-D printed materials into the body of experimental animals led to the development of cellular responses typical of aseptic inflammation, which testified to their biocompatibility.
{"title":"Histological examination and evaluation of biocompatibility of 3-D printed implants in the experiment.","authors":"D. Kuliesh, N. Galatenko, R. Rozhnova, V. Gritsenko, A. Bogdan, V. B. Volkov","doi":"10.26641/1997-9665.2020.1.35-41","DOIUrl":"https://doi.org/10.26641/1997-9665.2020.1.35-41","url":null,"abstract":"Background. High levels of musculoskeletal injuries, pathologies and various diseases of bone tissue encourage researchers around the world to actively seek out new and improve existing implant materials for high-quality reconstructive and restorative operations on bone tissue. Objective. Histological examination and evaluation of biocompatibility of 3-D printed implants after implantation in experimental animals. Methods. 3-D printed materials were implanted into the white laboratory rats Wistar for 1, 4, and 12 weeks. The cellular reactions of the organism and possible changes in the structure of the test specimens after implantation were studied by light microscopy by histological micropreparation analysis. Results. Histological examination was performed and the nature and dynamics of cellular responses after implantation of 3-D printed materials were evaluated. Conclusion. It was found that cellular migration and germination of connective tissue tendons deep into the implants due to the porous structure of 3-D printed material based on ceramics, resulted in partial degradation, which slightly increased the intensity of cellular reactions at all study periods. It was found that the intensity of cellular reactions was minimal in the early stages of the study around polymer-based 3-D printed material, but 12 weeks after implantation, cellular responses were increased. It is shown that implantation of 3-D printed materials into the body of experimental animals led to the development of cellular responses typical of aseptic inflammation, which testified to their biocompatibility.","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85599074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-19DOI: 10.26641/1997-9665.2020.1.16-22
A. Buryanov, M. Moroz, V. Kvasha, D. U. Kovalchuk, Ya. S. Dralov, D. A. Сhekushyn
Background. Chronically progressive course of psoriatic arthritis, not the certainty of pathogenetic units, and accordingly errors in diagnosis and treatment lead to significant negative results and disability of patients. Objective is to improve the results of the diagnosis of PA by examining the morphological features of the disease. Methods. Histomorphological studies performed on tissues removed during surgery on the joints in 32 patients. The material distributed into groups depending on the severity of the clinical manifestations of the disease. Results. At the beginning of the disease and at the exudative-proliferative stage, a pattern of pronounced inflammatory process, mainly exudative, serous-fibrinous character, was noted in the capsule of the joint. The most significant changes occurred in the synovial membrane, where marked proliferation of the integumentary synovial cells, hypertrophy and hyperplasia of the synovial membrane were observed with the formation of a large number of villi and folds. At histological examination in the tissues of the joint with a dystrophic-degenerative stage there was a pronounced exudative-proliferative inflammatory process, with significant degenerative-dystrophic and fibro-sclerotic changes. Conclusion. Histological studies in patients with PA, evidence of the presence of a sharp non-specific, non-peculiar, non-peculiar, non-peculiar, non-peculiar, non-peculiar, non-peculiar, syllabic history changes. Pathological changes in the articular cartilage and subordinate epiphysis bone are manifested by significant degenerative-dystrophic and destructive manifestations.
{"title":"Stage of morphological changes in psoriatic arthritis.","authors":"A. Buryanov, M. Moroz, V. Kvasha, D. U. Kovalchuk, Ya. S. Dralov, D. A. Сhekushyn","doi":"10.26641/1997-9665.2020.1.16-22","DOIUrl":"https://doi.org/10.26641/1997-9665.2020.1.16-22","url":null,"abstract":"Background. Chronically progressive course of psoriatic arthritis, not the certainty of pathogenetic units, and accordingly errors in diagnosis and treatment lead to significant negative results and disability of patients. Objective is to improve the results of the diagnosis of PA by examining the morphological features of the disease. Methods. Histomorphological studies performed on tissues removed during surgery on the joints in 32 patients. The material distributed into groups depending on the severity of the clinical manifestations of the disease. Results. At the beginning of the disease and at the exudative-proliferative stage, a pattern of pronounced inflammatory process, mainly exudative, serous-fibrinous character, was noted in the capsule of the joint. The most significant changes occurred in the synovial membrane, where marked proliferation of the integumentary synovial cells, hypertrophy and hyperplasia of the synovial membrane were observed with the formation of a large number of villi and folds. At histological examination in the tissues of the joint with a dystrophic-degenerative stage there was a pronounced exudative-proliferative inflammatory process, with significant degenerative-dystrophic and fibro-sclerotic changes. Conclusion. Histological studies in patients with PA, evidence of the presence of a sharp non-specific, non-peculiar, non-peculiar, non-peculiar, non-peculiar, non-peculiar, non-peculiar, syllabic history changes. Pathological changes in the articular cartilage and subordinate epiphysis bone are manifested by significant degenerative-dystrophic and destructive manifestations.","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86597262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-19DOI: 10.26641/1997-9665.2020.1.50-57
B. Shevchenko, O. V. Zeleniuk, O. Babii
Background. To date, there is no data on the possibility of using elastography to assess the functional morphology of the liver in extrahepatic cholestasis (EHC) of non-tumor genesis. Objective. To determine the status of functional morphology of the liver in patients with different types of EHC of non-tumoral genesis in comparison with elastometry. Methods. The analysis is based on a preoperative examination of 121 patients with EHC of non-tumor genesis,treated at the Department of Digestion Surgery of the Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine from 2013 to 2019, which were divided into 4 groups depending on the presence of jaundice and hepatocytes damage. All patients underwent standard clinical trials, US, SWE D2. The presence of endogenous intoxication (EI) was determined by the content of medium molecular peptides (MMP). Intraoperative liver biopsy was performed in 65 patients with different types of EHC non-tumoral genesis: 17 patients with type 1, 14 patients with type 2, 15 type 3 and 19 patients with type 4. Results . Variants of progression of changes in functional morphology of the liver were determined in 4 types of EHC of non-tumoral genesis in comparison with elastometry data and biochemical studies. Conclusion. Functional morphology of the liver depends on the type of EHC of non-tumoral genesis, with the progression of inflammation, varying degrees of destruction of hepatocytes, proliferation and destruction of ducts with obstruction of bile ducts, fibrosis and cirrhosis of the liver. According to SWE, liver stiffness does not reflect the actual status of functional liver morphology in patients with non-tumor EHC, but may indicate its duration.
{"title":"Functional morphology of the liver in extrahepatic cholestasis of non-tumor genesis.","authors":"B. Shevchenko, O. V. Zeleniuk, O. Babii","doi":"10.26641/1997-9665.2020.1.50-57","DOIUrl":"https://doi.org/10.26641/1997-9665.2020.1.50-57","url":null,"abstract":"Background. To date, there is no data on the possibility of using elastography to assess the functional morphology of the liver in extrahepatic cholestasis (EHC) of non-tumor genesis. Objective. To determine the status of functional morphology of the liver in patients with different types of EHC of non-tumoral genesis in comparison with elastometry. Methods. The analysis is based on a preoperative examination of 121 patients with EHC of non-tumor genesis,treated at the Department of Digestion Surgery of the Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine from 2013 to 2019, which were divided into 4 groups depending on the presence of jaundice and hepatocytes damage. All patients underwent standard clinical trials, US, SWE D2. The presence of endogenous intoxication (EI) was determined by the content of medium molecular peptides (MMP). Intraoperative liver biopsy was performed in 65 patients with different types of EHC non-tumoral genesis: 17 patients with type 1, 14 patients with type 2, 15 type 3 and 19 patients with type 4. Results . Variants of progression of changes in functional morphology of the liver were determined in 4 types of EHC of non-tumoral genesis in comparison with elastometry data and biochemical studies. Conclusion. Functional morphology of the liver depends on the type of EHC of non-tumoral genesis, with the progression of inflammation, varying degrees of destruction of hepatocytes, proliferation and destruction of ducts with obstruction of bile ducts, fibrosis and cirrhosis of the liver. According to SWE, liver stiffness does not reflect the actual status of functional liver morphology in patients with non-tumor EHC, but may indicate its duration.","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80554512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-19DOI: 10.26641/1997-9665.2020.1.58-61
M. L. Panasovskiy
Background. Studying of morphological features of spermatozoa obtained from men with azoospermia is due to the high rate of infertile marriages with a male factor. It is extremely important to estimate spermatozoa morphological characteristics, which can be a predictor of their fertilizing ability and therefore improve assisted reproductive technology (ART) results. Objective. The aim of the study was to assess the morphological characteristics of spermatozoa obtained during surgical inventions in patients with azoospermia. Methods. Evaluation of sperm morphology was performed using light microscopy. Statistic methods was used for data processing. Results . Morphological characteristics of spermatozoa obtained from patients with non-obstructive azoospermia were characterized by a higher rate of mixed pathology (head, neck and tail) then morphology of spermatozoa from men with obstructive azoospermia and normozoospermia (25 9 ± 1.38% vs 22.8 ± 2.44% and 34.6 ± 4.21%, respectively). Conclusion. The obtained morphology data of spermatozoa from men with obstructive and non-obstructive azoospermia will allow us to introduce an algorithm for assessing sperm quality for patients undergoing ART.
{"title":"Morphological features of testicular and epididymal spermatozoa obtained from azoospermic men.","authors":"M. L. Panasovskiy","doi":"10.26641/1997-9665.2020.1.58-61","DOIUrl":"https://doi.org/10.26641/1997-9665.2020.1.58-61","url":null,"abstract":"Background. Studying of morphological features of spermatozoa obtained from men with azoospermia is due to the high rate of infertile marriages with a male factor. It is extremely important to estimate spermatozoa morphological characteristics, which can be a predictor of their fertilizing ability and therefore improve assisted reproductive technology (ART) results. Objective. The aim of the study was to assess the morphological characteristics of spermatozoa obtained during surgical inventions in patients with azoospermia. Methods. Evaluation of sperm morphology was performed using light microscopy. Statistic methods was used for data processing. Results . Morphological characteristics of spermatozoa obtained from patients with non-obstructive azoospermia were characterized by a higher rate of mixed pathology (head, neck and tail) then morphology of spermatozoa from men with obstructive azoospermia and normozoospermia (25 9 ± 1.38% vs 22.8 ± 2.44% and 34.6 ± 4.21%, respectively). Conclusion. The obtained morphology data of spermatozoa from men with obstructive and non-obstructive azoospermia will allow us to introduce an algorithm for assessing sperm quality for patients undergoing ART.","PeriodicalId":19107,"journal":{"name":"Morphologia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88300826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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