Nutrition Journal最新文献

Background: Coffee and tea are among the most consumed drinks worldwide. Increasing evidence indicates an association between coffee or tea intake and neurodegenerative diseases. However, most studies have focused on the association of coffee or tea alone; studies on the interactive associations between coffee and tea and neurodegenerative diseases are few. Therefore, this study aimed to explore the individual or interactive associations between coffee and tea intake and neurodegenerative diseases and their various subtypes.

Methods: This study included 134,425 participants without neurodegenerative diseases at baseline in UK Biobank. A total of 6483 participants developed neurodegenerative diseases during a median follow-up time of 13.5 years. The median daily coffee intake was two cups, and the median daily tea intake was three cups. A restricted cubic spline was used to explore the nonlinear associations between coffee or tea intake and neurodegenerative diseases. The individual or interactive associations between coffee and tea intake and neurodegenerative diseases were assessed using the Cox proportional-hazards model.

Results: An individual association was noted between coffee or tea intake and neurodegenerative diseases. A significant J-shaped association was found between coffee intake and all-cause neurodegenerative diseases (Pnonlinear = 0.004) and vascular neurodegenerative diseases (Pnonlinear = 0.023), with increased risk at higher consumption. Moreover, a nonlinear association was observed between tea intake and all-cause neurodegenerative diseases (Pnonlinear = 0.004), vascular neurodegenerative diseases (Pnonlinear = 0.031), other neurodegenerative diseases (Pnonlinear = 0.002), and vascular dementia (VD) (Pnonlinear = 0.026). Furthermore, a significant interactive association was noted between coffee and tea intake among all-cause neurodegenerative diseases (Pinteraction = 0.004); Further, this interaction was also observed in Alzheimer's disease (AD) (Pinteraction = 0.006).

Conclusions: Excessive coffee consumption was significantly associated with an increased risk of all-cause neurodegenerative diseases and vascular neurodegenerative diseases. The results also showed that tea intake was associated with a reduced risk of all-cause neurodegenerative disease, vascular neurodegenerative disease, other neurodegenerative diseases, and VD. Moreover, coffee and tea had an interactive relationship with all-cause neurodegenerative diseases and AD, with specific combinations significantly associated with reduced risk of disease onset.

Background: To examine the association between plant protein intake and the risk of overall and site-specific cancers in a large prospective cohort.

Methods: This prospective cohort study included 192,428 participants from the UK Biobank, recruited from 2006 and followed until 2023. Plant protein consumption information was assessed using validated 24-hour dietary recalls. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of plant protein consumption with cancer risk were calculated using Cox proportional risk regression models. Nonlinear associations were tested using restricted cubic spline analysis.

Results: During a median follow-up of 11.2 years, 22,779 cancer events were recorded. Compared to participants in the lowest quartile of plant protein intake, those in the highest quartile had HRs for overall cancer, lung cancer, renal cancer, and colorectal cancer of 0.91 (95% CI = 0.88-0.95, P < 0.001), 0.86 (95% CI = 0.73-1.00, P = 0.048), 0.69 (95% CI = 0.55-0.87, P = 0.002), and 0.89 (95% CI = 0.79-1.00, P = 0.046), respectively. Furthermore, each 10% increase in the ratio of plant protein to total daily protein was associated with a 3% lower overall cancer risk (HR = 0.97, 95% CI = 0.95-0.98, P < 0.001). Subgroup analyses suggested that the negative association was more pronounced in male. Among individuals who did not meet the WHO-recommended protein intake, a nonlinear association between plant protein intake and overall cancer risk was observed, characterized by a modest reduction in risk at moderate intake levels with no further risk reduction at higher intake levels (P for nonlinearity = 0.02).

Conclusion: This cohort study indicates that higher dietary plant protein intake is significantly associated with a reduced risk of overall and specific cancers, including lung, renal, and colorectal cancer. These findings support the notion that increasing the consumption of plant protein-rich foods is beneficial for health.