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The EAT-Lancet diet associated cardiovascular health parameters: evidence from a Brazilian study. 与心血管健康参数相关的 EAT-Lancet 饮食:来自巴西研究的证据。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-10-01 DOI: 10.1186/s12937-024-01021-4
Rosa Sá de Oliveira Neta, Severina Carla Vieira Cunha Lima, Maria Fernanda Araújo de Medeiros, David Bruno Melo Araújo, Nicole Bernardi, Armando Augusto Noberto Galdino de Araújo, Michelle Cristine Medeiros Jacob, Adélia da Costa Pereira de Arruda Neta, Dirce Maria Lobo Marchioni, Clélia de Oliveira Lyra, Angelo Giuseppe Roncalli da Costa Oliveira

Background: The EAT-Lancet diet is a diet aimed at promoting population and planetary health from the perspective of sustainable diets in terms of environmental and health aspects. This study aimed to assess the association between adherence to the EAT-Lancet diet and cardiometabolic risk factors among adults and elderly individuals in a capital city in the northeastern region of Brazil.

Methods: This is an analytical cross-sectional observational study from a population-based sample conducted between 2019 and 2020, involving 398 non-institutionalized adults and elderly people, of both sexes from "Brazilian Usual Consumption Assessment" study (Brazuca-Natal). There was a 38% response rate due to the suspension of data collection due to the covid-19 pandemic, but According to the comparative analysis of socioeconomic and demographic variables between the surveyed and non-surveyed sectors, losses were found to be random (p = 0.135, Little's MCAR test). Socioeconomic and lifestyle data, anthropometric measurements, and dietary consumption were collected. We used the Planetary Health Diet Index (PHDI) and the Cardiovascular Health Diet Index (CHDI) for cardiovascular health to assess adherence to the diet's sustainability. The evaluated cardiometabolic parameters included fasting blood glucose, triglycerides, total cholesterol, HDL-C, LDL-C, and systolic and diastolic blood pressure measurements. We also assessed the presence of type 2 diabetes mellitus, arterial hypertension, and dyslipidemia. For the data analyses, sample weights and the effect of the study design were taken into account. Pearson's chi-square test was used to evaluate the statistical significance of frequencies. Multiple linear regression models assessed the associations between PHDI and CHDI and its components and the cardiometabolic parameters.

Results: The mean PHDI was 29.4 (95% CI 28.04:30.81), on a total score ranging from 0 to 150 points and the mean CHDI was 32.63 (95% CI 31.50:33.78), on a total score ranging from 0 to 110 points. PHDI showed a significant positive association with the final CHDI score and components of fruits, vegetables, and legumes, and a negative association with Ultra-processed Food (UPF) (p < 0.05). Notably, among the most consumed UPF, the following stand out: "packaged snacks, shoestring potatoes, and crackers" (16.94%), followed by margarine (14.14%). The PHDI exhibited a significant association with diabetes and dyslipidemia, as well as with systolic blood pressure, total cholesterol, and LDL-C.

Conclusions: The results suggest that adopting the EAT-Lancet diet is associated with the improvement of key cardiovascular health indicators.

背景:EAT-Lancet 饮食是从环境和健康方面考虑的可持续饮食,旨在促进人口和地球健康。本研究旨在评估巴西东北部地区一个省会城市的成年人和老年人坚持 EAT-Lancet 饮食与心脏代谢风险因素之间的关系:这是一项分析性横断面观察研究,在2019年至2020年期间进行了人口抽样调查,涉及 "巴西通常消费评估 "研究(Brazuca-Natal)中的398名非住院成年人和老年人,男女均有。由于covid-19大流行病,数据收集工作暂停,因此回复率为38%,但根据对接受调查和未接受调查人群的社会经济和人口变量的比较分析,发现损失是随机的(P = 0.135,Little's MCAR检验)。我们收集了社会经济和生活方式数据、人体测量数据以及膳食消费数据。我们使用行星健康膳食指数(PHDI)和心血管健康膳食指数(CHDI)来评估膳食的可持续性。评估的心血管代谢参数包括空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇以及收缩压和舒张压测量值。我们还评估了是否患有 2 型糖尿病、动脉高血压和血脂异常。在进行数据分析时,我们考虑了样本权重和研究设计的影响。皮尔逊卡方检验用于评估频率的统计学意义。多元线性回归模型评估了 PHDI 和 CHDI 及其组成部分与心脏代谢参数之间的关系:PHDI的平均值为29.4(95% CI 28.04:30.81),总分从0分到150分不等;CHDI的平均值为32.63(95% CI 31.50:33.78),总分从0分到110分不等。PHDI 与 CHDI 最终得分及水果、蔬菜和豆类成分呈显著正相关,而与超加工食品(UPF)呈负相关(P 结论:PHDI 与 CHDI 最终得分及水果、蔬菜和豆类成分呈显著正相关,而与超加工食品(UPF)呈负相关:结果表明,采用 EAT-Lancet 饮食与主要心血管健康指标的改善有关。
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引用次数: 0
Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial. 姜黄素提取物可改善肥胖 2 型糖尿病患者的β细胞功能:随机对照试验。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-10-01 DOI: 10.1186/s12937-024-01022-3
Metha Yaikwawong, Laddawan Jansarikit, Siwanon Jirawatnotai, Somlak Chuengsamarn

Background: Type 2 diabetes mellitus (T2DM) is a chronic condition characterized by insulin resistance and impaired insulin production, leading to elevated blood glucose levels. Curcumin, a polyphenolic compound from Curcuma longa, has shown potential in improving insulin sensitivity and reducing blood glucose levels, which may help mitigate type 2 diabetes progression.

Objective: To assess the efficacy of improving type 2 diabetes (T2DM).

Study design: This randomized, double-blind, placebo-controlled trial included subjects (n = 272) with criteria for type 2 diabetes.

Methods: All subjects were randomly assigned to receive curcumin (1500 mg/day) or placebo with blind labels for 12 months. To assess the improvement of T2DM after curcumin treatments body weight and body mass index, fasting plasma glucose, glycosylated hemoglobin A1c, β-cell function (homeostasis model assessment [HOMA-β]), insulin resistance (HOMA-IR), insulin, adiponectin, and leptin were monitored at the baseline and at 3-, 6-, 9-, and 12-month visits during the course of intervention.

Results: After 12 months of treatment, the curcumin-treated group showed a significant decrease in fasting blood glucose (115.49 vs.130.71; P < 0.05), HbA1c (6.12 vs. 6.47; P < 0.05). In addition, the curcumin-treated group showed a better overall function of β-cells, with higher HOMA-β (136.20 vs. 105.19; P < 0.01) The curcumin-treated group showed a lower level of HOMA-IR (4.86 vs. 6.04; P < 0.001) and higher adiponectin (14.51 vs. 10.36; P < 0.001) when compared to the placebo group. The curcumin-treated group also showed a lower level of leptin (9.42 vs. 20.66; P < 0.001). Additionally, body mass index was lowered (25.9 4 vs.29.34), with a P value of 0.001.

Conclusions: A 12-month curcumin intervention in type 2 diabetes patients shows a significant glucose-lowering effect. Curcumin treatment appeared to improve the overall function of β-cells and reduce both insulin resistance and body weight, with very minor adverse effects. Curcumin intervention in obese patients with type 2 diabetes may be beneficial.

Trial registration: Thai clinical trials regentrify no.20140303003.

背景:2 型糖尿病(T2DM)是一种慢性疾病,其特点是胰岛素抵抗和胰岛素分泌受损,从而导致血糖水平升高。姜黄素是一种从姜黄中提取的多酚化合物,已显示出改善胰岛素敏感性和降低血糖水平的潜力,这可能有助于缓解 2 型糖尿病的进展:评估改善 2 型糖尿病(T2DM)的疗效:这项随机、双盲、安慰剂对照试验纳入了符合 2 型糖尿病标准的受试者(n = 272):所有受试者均被随机分配接受姜黄素(1500 毫克/天)或安慰剂治疗,盲标治疗 12 个月。为了评估姜黄素治疗后 T2DM 的改善情况,在基线和干预过程中的 3、6、9 和 12 个月访视时监测体重和体重指数、空腹血浆葡萄糖、糖化血红蛋白 A1c、β 细胞功能(稳态模型评估 [HOMA-β])、胰岛素抵抗(HOMA-IR)、胰岛素、脂联素和瘦素:治疗 12 个月后,姜黄素治疗组的空腹血糖显著下降(115.49 vs. 130.71;P 1c(6.12 vs. 6.47;P 结论:姜黄素干预治疗 12 个月后,空腹血糖显著下降(115.49 vs. 130.71;P 1c(6.12 vs. 6.47;P 1c):对 2 型糖尿病患者进行为期 12 个月的姜黄素干预具有明显的降糖效果。姜黄素治疗似乎改善了β细胞的整体功能,降低了胰岛素抵抗和体重,不良反应非常轻微。姜黄素对肥胖的2型糖尿病患者的干预可能是有益的:泰国临床试验登记号:20140303003。
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引用次数: 0
Associations of healthy eating patterns with biological aging: national health and nutrition examination survey (NHANES) 1999-2018. 健康饮食模式与生物衰老的关系:1999-2018 年全国健康与营养状况调查(NHANES)。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-28 DOI: 10.1186/s12937-024-01017-0
Xuanyang Wang, Xuemin Yan, Jia Zhang, Sijia Pan, Ran Li, Licheng Cheng, Xiang Qi, Lin Li, Ying Li

Background: Healthy dietary patterns have been negatively associated with methylation-based measures of biological age, yet previous investigations have been unable to establish the relationship between them and biological aging assessed through blood chemistry-based clinical biomarkers. We sought to assess the associations of 4 dietary metrics with 4 measures of biological age.

Methods: Among 16,666 participants in NHANES 1999-2018, 4 dietary metrics [Dietary inflammatory index (DII), Dietary approaches to stop hypertension index (DASH), Alternate mediterranean diet score (aMED), and Healthy eating index-2015 (HEI-2015)] were calculated through the 'dietaryindex' R package. Twelve blood chemistry parameters were utilized to compute 4 indicators of biological age [homeostatic dysregulation (HD), allostatic load (AL), Klemera-Doubal method (KDM), and phenotypic age (PA)]. Binomial logistic regression models and restricted cubic spline (RCS) regression were employed to evaluate the associations.

Results: All 4 dietary metrics were significantly associated with biological age acceleration or deceleration. In comparison to the lowest DII, the odds ratios (ORs) for accelerated HD, AL, KDM, and PA were 1.25 (1.08,1.45), 1.29 (1.11,1.50), 1.34 (1.08,1.65), and 1.61 (1.39,1.87) for the highest. The multivariable-adjusted ORs of the highest quartile of DASH, aMED, and HEI-2015 were 0.85 (0.73,0.97), 0.88 (0.74,1.04), and 0.84 (0.74,0.96) for HD, 0.64 (0.54,0.75), 0.61 (0.52,0.72), and 0.70 (0.59,0.82) for AL, 0.68 (0.54,0.85), 0.62 (0.50,0.76), and 0.71 (0.58,0.87) for KDM, and 0.50 (0.42,0.59), 0.64 (0.54,0.76), and 0.51 (0.44,0.58) for PA when compared with the lowest level. The findings were validated by the best-fitting dose-response curves for the associations. Among participants consuming dietary supplements (Pinteraction < 0.05), the positive effects of a healthy dietary pattern on biological aging were more pronounced. Systemic immune inflammation index (SII) and atherogenic index of plasma (AIP) were identified as being involved in and mediating the associations.

Conclusions: Biological aging assessed through blood chemistry-based clinical biomarkers is negatively associated with diet quality. The anti-aging benefits of improving the diet may be due to its ability to reduce inflammation and lower blood lipids.

背景:健康的膳食模式与基于甲基化的生物年龄测量呈负相关,但以往的研究却无法确定它们与通过基于血液化学的临床生物标志物评估的生物衰老之间的关系。我们试图评估 4 种膳食指标与 4 种生物年龄指标之间的关系:在 NHANES 1999-2018 年的 16,666 名参与者中,通过 "dietaryindex "R 软件包计算了 4 个膳食指标[膳食炎症指数(DII)、膳食高血压防治指数(DASH)、替代地中海饮食评分(aMED)和健康饮食指数-2015(HEI-2015)]。利用 12 个血液化学参数计算了 4 个生物年龄指标[稳态失调(HD)、异位负荷(AL)、Klemera-Doubal 法(KDM)和表型年龄(PA)]。采用二项式逻辑回归模型和限制性立方样条(RCS)回归来评估这些关联:结果:所有 4 个膳食指标都与生物年龄加速或减速有显著相关性。与最低 DII 相比,最高 DII 的 HD、AL、KDM 和 PA 加速的几率比(ORs)分别为 1.25(1.08,1.45)、1.29(1.11,1.50)、1.34(1.08,1.65)和 1.61(1.39,1.87)。DASH、aMED和HEI-2015的最高四分位数的多变量调整OR分别为0.85(0.73,0.97)、0.88(0.74,1.04)和0.84(0.74,0.96),HD为0.64(0.54,0.75)、0.61(0.52,0.72)和0.与最低水平相比,AL 为 70(0.59,0.82),KDM 为 0.68(0.54,0.85)、0.62(0.50,0.76)和 0.71(0.58,0.87),PA 为 0.50(0.42,0.59)、0.64(0.54,0.76)和 0.51(0.44,0.58)。这些研究结果得到了最佳拟合剂量-反应曲线的验证。在食用膳食补充剂的参与者中(Pinteraction < 0.05),健康饮食模式对生物衰老的积极影响更为明显。全身免疫炎症指数(SII)和血浆致动脉粥样硬化指数(AIP)被认为参与并介导了这些关联:结论:通过血液化学临床生物标志物评估的生物衰老与饮食质量呈负相关。结论:通过基于血液化学的临床生物标志物评估的生物衰老与饮食质量呈负相关。改善饮食对抗衰老的益处可能在于其减少炎症和降低血脂的能力。
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引用次数: 0
Association between nut consumption and mortality risk: a 20-year cohort study in Korea with a stratified analysis by health-related variables. 坚果消费与死亡风险之间的关系:韩国一项为期 20 年的队列研究,根据健康相关变量进行分层分析。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-28 DOI: 10.1186/s12937-024-01019-y
Hye Ran Shin, Jihye Kim, SuJin Song

Background: Although nuts are a well-known healthy food group, the relationship between nut consumption and mortality remains unclear, particularly among Asians. This prospective cohort study examined the association between nut consumption and the risk of all-cause, cardiovascular disease (CVD), and cancer mortality in Korean adults.

Methods: Data from two cohorts (the Ansan-Ansung and Health-Examinees) from the Korean Genome and Epidemiology Study were used. A total of 114,140 individuals aged 40-79 years were included in the data analyses. Nut consumption was assessed using a validated semi-quantitative food frequency questionnaire and categorized into four groups: non-consumers, less than 1 serving/week, 1-2 servings/week, and 2 or more servings/week (one serving was 15 g of nuts). Mortality outcomes were determined based on the 2001-2021 death records from Statistics Korea. Cox proportional hazard regression analysis was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality across nut consumption categories. A stratified subgroup analysis by health-related variables was also performed.

Results: During a mean follow-up of 12.3 years, 4,559 deaths were recorded. After adjusting for covariates, the HR for all-cause mortality was 0.877 (95% CI = 0.772-0.996, p for trend = 0.006) in individuals with a nut consumption of 2 or more servings/week compared with that in non-consumers. Multivariable HRs for CVD mortality were 0.800 (95% CI = 0.681-0.939) in individuals consuming less than 1 serving/week, 0.656 (95% CI = 0.469-0.918) in those consuming 1-2 servings/week, and 1.009 (95% CI = 0.756-1.347) in those consuming 2 or more servings/week compared with that in non-consumers (p for trend = 0.080). No association was observed between nut consumption and cancer mortality. Stratified analysis identified significant interactions in the association between nut consumption and all-cause mortality by age, body mass index, and physical activity.

Conclusions: Nut consumption was linearly associated with the reduced risk of all-cause mortality and showed a non-linear dose-response relationship with CVD mortality in Koreans, but had no association with cancer mortality. The effects of nut consumption, which have been inadequately investigated in this population, varied across different subgroups. These findings suggest that incorporating nuts into the diet should be encouraged for long-term health of Korean adults.

背景:虽然坚果是众所周知的健康食品,但坚果消费与死亡率之间的关系仍不清楚,尤其是在亚洲人中。这项前瞻性队列研究考察了韩国成年人食用坚果与全因、心血管疾病(CVD)和癌症死亡风险之间的关系:研究使用了韩国基因组与流行病学研究中两个队列(安山安星队列和健康受试者队列)的数据。共有 114140 名 40-79 岁的人被纳入数据分析。坚果食用量通过有效的半定量食物频率问卷进行评估,并分为四组:非食用者、每周少于 1 份、每周 1-2 份和每周 2 份或以上(1 份为 15 克坚果)。死亡率结果是根据韩国统计局 2001-2021 年的死亡记录确定的。采用考克斯比例危险回归分析法计算不同坚果摄入量类别的死亡率危险比(HRs)和95%置信区间(CIs)。此外,还根据健康相关变量进行了分层分组分析:在平均 12.3 年的随访期间,共记录了 4,559 例死亡。在对协变量进行调整后,与不食用坚果者相比,每周食用 2 份或更多坚果者的全因死亡率 HR 为 0.877(95% CI = 0.772-0.996,趋势 p = 0.006)。与非食用者相比,每周食用不到 1 份坚果的人心血管疾病死亡率的多变量 HR 值为 0.800(95% CI = 0.681-0.939),每周食用 1-2 份坚果的人心血管疾病死亡率的多变量 HR 值为 0.656(95% CI = 0.469-0.918),每周食用 2 份或更多坚果的人心血管疾病死亡率的多变量 HR 值为 1.009(95% CI = 0.756-1.347)(趋势 p = 0.080)。未观察到坚果食用量与癌症死亡率之间存在关联。分层分析发现,坚果摄入量与全因死亡率之间的关系在年龄、体重指数和体力活动方面存在明显的相互作用:结论:食用坚果与韩国人全因死亡风险的降低呈线性关系,与心血管疾病死亡率呈非线性剂量反应关系,但与癌症死亡率没有关系。对韩国人食用坚果的影响还没有进行充分的研究,不同的亚群对食用坚果的影响也不尽相同。这些研究结果表明,为了韩国成年人的长期健康,应鼓励在饮食中加入坚果。
{"title":"Association between nut consumption and mortality risk: a 20-year cohort study in Korea with a stratified analysis by health-related variables.","authors":"Hye Ran Shin, Jihye Kim, SuJin Song","doi":"10.1186/s12937-024-01019-y","DOIUrl":"https://doi.org/10.1186/s12937-024-01019-y","url":null,"abstract":"<p><strong>Background: </strong>Although nuts are a well-known healthy food group, the relationship between nut consumption and mortality remains unclear, particularly among Asians. This prospective cohort study examined the association between nut consumption and the risk of all-cause, cardiovascular disease (CVD), and cancer mortality in Korean adults.</p><p><strong>Methods: </strong>Data from two cohorts (the Ansan-Ansung and Health-Examinees) from the Korean Genome and Epidemiology Study were used. A total of 114,140 individuals aged 40-79 years were included in the data analyses. Nut consumption was assessed using a validated semi-quantitative food frequency questionnaire and categorized into four groups: non-consumers, less than 1 serving/week, 1-2 servings/week, and 2 or more servings/week (one serving was 15 g of nuts). Mortality outcomes were determined based on the 2001-2021 death records from Statistics Korea. Cox proportional hazard regression analysis was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality across nut consumption categories. A stratified subgroup analysis by health-related variables was also performed.</p><p><strong>Results: </strong>During a mean follow-up of 12.3 years, 4,559 deaths were recorded. After adjusting for covariates, the HR for all-cause mortality was 0.877 (95% CI = 0.772-0.996, p for trend = 0.006) in individuals with a nut consumption of 2 or more servings/week compared with that in non-consumers. Multivariable HRs for CVD mortality were 0.800 (95% CI = 0.681-0.939) in individuals consuming less than 1 serving/week, 0.656 (95% CI = 0.469-0.918) in those consuming 1-2 servings/week, and 1.009 (95% CI = 0.756-1.347) in those consuming 2 or more servings/week compared with that in non-consumers (p for trend = 0.080). No association was observed between nut consumption and cancer mortality. Stratified analysis identified significant interactions in the association between nut consumption and all-cause mortality by age, body mass index, and physical activity.</p><p><strong>Conclusions: </strong>Nut consumption was linearly associated with the reduced risk of all-cause mortality and showed a non-linear dose-response relationship with CVD mortality in Koreans, but had no association with cancer mortality. The effects of nut consumption, which have been inadequately investigated in this population, varied across different subgroups. These findings suggest that incorporating nuts into the diet should be encouraged for long-term health of Korean adults.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic value of the geriatric nutritional risk index in patients with non-metastatic clear cell renal cell carcinoma: a propensity score matching analysis. 非转移性透明细胞肾细胞癌患者老年营养风险指数的预后价值:倾向得分匹配分析。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-28 DOI: 10.1186/s12937-024-01010-7
Huiyu Zhou, Dingyang Lv, Fan Cui, Qian Gong, Jinshuai Li, Jie Wen, Mohan Jia, Yinbo Kang, Yi Rong, Wenlong Zhang, Weibing Shuang

Background: This study aimed to investigate the prognostic value of the geriatric nutritional risk index (GNRI) in patients with non-metastatic clear cell renal cell carcinoma (ccRCC) who underwent nephrectomy.

Methods: Patients with non-metastatic ccRCC who underwent nephrectomy between 2013 and 2021 were analyzed retrospectively. The GNRI was calculated within one week before surgery. The optimal cut-off value of GNRI was determined using X-tile software, and the patients were divided into a low GNRI group and a high GNRI group. The Kaplan-Meier method was used to compare the overall survival (OS), cancer-specific survival (CSS) and recurrence-free survival (RFS) between the two groups. Univariate and multivariate Cox proportional hazard models were used to determine prognostic factors. In addition, propensity score matching (PSM) was performed with a matching ratio of 1:3 to minimize the influence of confounding factors. Variables entered into the PSM model were as follows: sex, age, history of hypertension, history of diabetes, smoking history, BMI, tumor sidedness, pT stage, Fuhrman grade, surgical method, surgical approach, and tumor size.

Results: A total of 645 patients were included in the final analysis, with a median follow-up period of 37 months (range: 1-112 months). The optimal cut-off value of GNRI was 98, based on which patients were divided into two groups: a low GNRI group (≤ 98) and a high GNRI group (> 98). Kaplan-Meier analysis showed that OS (P < 0.001), CSS (P < 0.001) and RFS (P < 0.001) in the low GNRI group were significantly worse than those in the high GNRI group. Univariate and multivariate Cox analysis showed that GNRI was an independent prognostic factor of OS, CSS and RFS. Even after PSM, OS (P < 0.05), CSS (P < 0.05) and RFS (P < 0.05) in the low GNRI group were still worse than those in the high GNRI group. In addition, we observed that a low GNRI was associated with poor clinical outcomes in elderly subgroup (> 65) and young subgroup (≤ 65), as well as in patients with early (pT1-T2) and low-grade (Fuhrman I-II) ccRCC.

Conclusion: As a simple and practical tool for nutrition screening, the preoperative GNRI can be used as an independent prognostic indicator for postoperative patients with non-metastatic ccRCC. However, larger prospective studies are necessary to validate these findings.

背景:本研究旨在探讨老年营养风险指数(GNRI)在接受肾切除术的非转移性透明细胞肾癌(ccRCC)患者中的预后价值:对2013年至2021年间接受肾切除术的非转移性ccRCC患者进行回顾性分析。在手术前一周内计算 GNRI。使用X-tile软件确定GNRI的最佳临界值,并将患者分为低GNRI组和高GNRI组。采用 Kaplan-Meier 法比较两组患者的总生存期(OS)、癌症特异性生存期(CSS)和无复发生存期(RFS)。采用单变量和多变量考克斯比例危险模型确定预后因素。此外,还进行了倾向评分匹配(PSM),匹配比例为 1:3,以尽量减少混杂因素的影响。输入 PSM 模型的变量如下:性别、年龄、高血压病史、糖尿病病史、吸烟史、体重指数、肿瘤侧位、pT 分期、Fuhrman 分级、手术方法、手术方式和肿瘤大小:共有 645 名患者纳入最终分析,中位随访时间为 37 个月(范围:1-112 个月)。GNRI的最佳临界值为98,根据该临界值,患者被分为两组:低GNRI组(≤98)和高GNRI组(>98)。Kaplan-Meier 分析显示,低 GNRI 组的 OS(P < 0.001)、CSS(P < 0.001)和 RFS(P < 0.001)明显差于高 GNRI 组。单变量和多变量Cox分析显示,GNRI是OS、CSS和RFS的独立预后因素。即使在 PSM 后,低 GNRI 组的 OS(P < 0.05)、CSS(P < 0.05)和 RFS(P < 0.05)仍比高 GNRI 组差。此外,我们还观察到,在老年亚组(大于 65 岁)和年轻亚组(小于 65 岁)以及早期(pT1-T2)和低级别(Fuhrman I-II)ccRCC 患者中,低 GNRI 与较差的临床预后相关:结论:作为一种简单实用的营养筛查工具,术前 GNRI 可作为非转移性 ccRCC 患者术后的独立预后指标。不过,还需要更大规模的前瞻性研究来验证这些发现。
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引用次数: 0
Associations between maternal diet, family eating habits and preschool children's dietary patterns: insights from the UPBEAT trial. 母亲饮食、家庭饮食习惯与学龄前儿童饮食模式之间的关系:UPBEAT 试验的启示。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-28 DOI: 10.1186/s12937-024-01023-2
Veronica Luque, Fernanda Mucarzel, Anna Hertogs, Paul T Seed, Angela C Flynn, Lucilla Poston, Kathryn V Dalrymple

Background: Dietary behaviours in early life often track across the life course, influencing the development of adverse health outcomes such as obesity and cardiovascular disease. This study aimed to explore the between dietary patterns (DP) in preschool children and maternal DP and family eating habits.

Methods: We conducted a secondary analysis of 488 mother-child pairs from the UK pregnancy Better Eating and Activity Trial (UPBEAT) at 3-year follow-up. Previously published DP from mothers and children (derived from food-frequency questionnaires and exploratory factor analysis) were used. Mothers' DP were "Fruits-Vegetables", "African-Caribbean", "Processed and Snacks", and children's DP were "Prudent", "Processed-Snacking", and "African-Caribbean". Family meal environments were evaluated using a 5-point Likert scale.

Results: Linear regression models revealed that child's prudent pattern was positively associated with maternal Fruits-Vegetables (B = 0.18 (0.08, 0.27)), Snacks patterns (B = 0.10 (0.01, 0.18)), and eating the same foods during meals (B = 0.25 (0.07, 0.43)). Child's Processed-Snacking pattern was directly associated with maternal Processed (B = 0.22 (0.13, 0.30)) and Snacks (B = 0.27 (0.18, 0.36)) patterns, receiving food as reward (B = 0.22 (0.04, 0.39)) and watching TV during meals (B = 0.27 (0.09, 0.45)). Finally, the child African-Caribbean pattern was directly associated with that from the mother (B = 0.41 (0.33, 0.50)) and watching TV during meals (B = 0.15 (0.09, 0.30)), and inversely associated with maternal processed (B=-0.09 (-0.17, -0.02)) and snacking (B=-0.08 (-0.15, -0.04)) patterns.

Conclusions: Unhealthy dietary patterns in childhood are directly linked to similar maternal patterns and family meal behaviours, such as television viewing and food rewards. These findings highlight targetable behaviours for public health interventions.

背景:生命早期的饮食行为往往贯穿整个生命过程,影响肥胖和心血管疾病等不良健康后果的发展。本研究旨在探讨学龄前儿童的饮食模式(DP)与母亲的饮食模式和家庭饮食习惯之间的关系:我们对英国妊娠期更佳饮食和活动试验(UPBEAT)中的 488 对母子进行了为期 3 年的二次分析。我们采用了之前公布的母亲和孩子的饮食习惯(通过食物频率问卷调查和探索性因素分析得出)。母亲的饮食习惯是 "水果-蔬菜"、"非洲-加勒比"、"加工食品和零食",儿童的饮食习惯是 "谨慎"、"加工食品-零食 "和 "非洲-加勒比"。家庭膳食环境采用 5 点李克特量表进行评估:线性回归模型显示,儿童的谨慎模式与母亲的水果-蔬菜(B = 0.18 (0.08, 0.27))、零食模式(B = 0.10 (0.01, 0.18))和进餐时吃同样的食物(B = 0.25 (0.07, 0.43))呈正相关。儿童的加工零食模式与母亲的加工(B = 0.22 (0.13, 0.30))和零食(B = 0.27 (0.18, 0.36))模式、接受食物作为奖励(B = 0.22 (0.04, 0.39))和进餐时看电视(B = 0.27 (0.09, 0.45))直接相关。最后,非裔加勒比海儿童的饮食模式与母亲的饮食模式(B = 0.41 (0.33, 0.50))和吃饭时看电视(B = 0.15 (0.09, 0.30))直接相关,而与母亲加工(B=-0.09 (-0.17, -0.02))和吃零食(B=-0.08 (-0.15, -0.04))的饮食模式成反比:结论:儿童时期不健康的饮食模式与类似的母亲模式和家庭用餐行为(如看电视和食物奖励)直接相关。这些发现凸显了公共卫生干预的目标行为。
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引用次数: 0
Correction: Olfactory performance and odor liking are negatively associated with food neophobia in children aged between 3 and 9 years. 更正:3至9岁儿童的嗅觉表现和气味喜好与食物新恐惧症呈负相关。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-27 DOI: 10.1186/s12937-024-01015-2
Agnieszka Sorokowska, Dominika Chabin, Aleksandra Kamieńska, Sabina Barszcz, Katarzyna Byczyńska, Klaudia Fuławka, Arkadiusz Urbanek, Anna Oleszkiewicz
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引用次数: 0
Dietary pattern trajectories in early childhood and their associations with patterns of maternal feeding practices in a multi-ethnic Asian cohort. 一个多民族亚洲队列中幼儿期的饮食模式轨迹及其与母亲喂养方式的关系。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-20 DOI: 10.1186/s12937-024-01012-5
Geeta Appannah, Jia Ying Toh, Jun Shi Lai, Heng Yaw Yong, Zalilah Mohd Shariff, Mya Thway Tint, Wen Lun Yuan, Wei Wei Pang, Keith M Godfrey, Kok Hian Tan, Fabian Yap, Yung Seng Lee, Johan G Eriksson, Mary F F Chong

Background: Maternal feeding practices play a major role in children's dietary intakes. However, there is limited data on the associations between trajectories of dietary patterns (DPs) and patterns of maternal feeding practices during early childhood.

Methods: Using data from a multi-ethnic Asian cohort study, namely the Growing Up in Singapore Towards healthy Outcomes (GUSTO), dietary intakes were measured using Food Frequency Questionnaires in children at 18 months, 5 and 7 years of age. Maternal feeding practices were assessed using validated questionnaires at 15 months, 3 and 5 years of age. Principal component analysis was used to derive 2 major DPs at all time-points as well as patterns of maternal feeding practices. Group-based trajectory modelling was used to identify trajectory groups for the derived DPs. Multivariable logistic regression examined associations between patterns of maternal feeding practices and DP trajectory groups.

Results: Two DPs, namely the 'healthy' and 'less healthy' were consistently derived at 18 months, 5 and 7 years of age. From each DP, 2 stable DP trajectory groups were further identified between 18 months and 7 years of age. For the 'healthy' DP trajectory, majority of the children (Group 1) formed a consistent average adherence trajectory group (91.8%) while the remaining children (Group 2) showed a higher but decreasing adherence (8.2%) to this DP. For the 'less healthy' DP trajectory, most children (Group 1) formed a consistent average adherence trajectory (95.5%), while the remainder (Group 2) showed consistent higher adherence to this 'less healthy' DP (4.5%). Two patterns of maternal feeding practices were derived and labelled as 'structured with autonomy support' and 'coercive control', respectively, at ages 15 months, 3 and 5 years. Children whose mothers showed high adherence to the structured with autonomy support feeding practices at age 5 years were significantly more likely to be associated with the higher but decreasing 'healthy' DP trajectory group [OR = 3.62 (95% CI: 1.64, 7.99)].

Conclusions: A small number of children in this multi-ethnic study showed high adherence to the 'healthy' or 'less healthy' DP trajectory groups, respectively, while the majority showed average adherence to either of these trajectories. The positive association between structured with autonomy support maternal feeding practices and higher z-scores for the healthy DP trajectory highlights the importance of guiding parents on appropriate feeding practices.

背景:母亲的喂养方式对儿童的膳食摄入量起着重要作用。然而,有关幼儿期膳食模式(DPs)轨迹与母亲喂养方式之间关系的数据却很有限:方法:利用一项多种族亚洲队列研究(即 "在新加坡成长,迈向健康结果"(GUSTO))的数据,使用食物频率问卷调查法测量儿童在 18 个月、5 岁和 7 岁时的膳食摄入量。对 15 个月、3 岁和 5 岁儿童的母亲喂养方式则采用有效问卷进行评估。采用主成分分析法得出所有时间点的两个主要数据集以及母亲喂养方式的模式。基于群体的轨迹模型被用来确定衍生出的DPs的轨迹群体。多变量逻辑回归检验了产妇喂养方式与DP轨迹组之间的关联:结果:在 18 个月、5 岁和 7 岁时,持续得出两个 DP,即 "健康 "和 "不太健康"。在每个DP中,进一步确定了18个月至7岁期间两个稳定的DP轨迹组。就 "健康 "DP轨迹而言,大多数儿童(第 1 组)形成了一个稳定的平均坚持率轨迹组(91.8%),而其余儿童(第 2 组)对这一DP的坚持率较高,但呈下降趋势(8.2%)。至于 "不太健康 "的喂养模式轨迹,大多数儿童(第 1 组)形成了一致的平均喂养模式轨迹(95.5%),而其余儿童(第 2 组)对这一 "不太健康 "的喂养模式的依从性较高(4.5%)。在 15 个月、3 岁和 5 岁时,得出了两种母亲喂养方式,并分别标记为 "结构化自主支持 "和 "强制控制"。在5岁时,如果母亲高度坚持 "有自主支持的结构化喂养 "方式,则其子女明显更有可能属于 "健康 "DP轨迹较高但不断下降的组别[OR = 3.62 (95% CI: 1.64, 7.99)]:在这项多种族研究中,少数儿童分别表现出与 "健康 "或 "较不健康 "DP轨迹组的高度一致性,而大多数儿童则表现出与这两种轨迹的一般一致性。有自主支持的结构化母亲喂养方式与较高的健康DP轨迹z-分数之间存在正相关,这凸显了指导父母采取适当喂养方式的重要性。
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引用次数: 0
Correction: Consumption of different types of meat and the risk of chronic limb-threatening ischemia: the Singapore Chinese Health Study. 更正:食用不同种类的肉类与慢性肢体缺血风险:新加坡华人健康研究。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-19 DOI: 10.1186/s12937-024-01014-3
Ariel Fangting Ying, Mohammad Talaei, Derek John Hausenloy, Woon-Puay Koh
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引用次数: 0
Adherence to the EAT-Lancet index is associated with lower diet costs in the Mexican population. 遵守 EAT-Lancet 指数可降低墨西哥人的饮食成本。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-09-19 DOI: 10.1186/s12937-024-01002-7
Tania C Aburto, Juan Carlos Salgado, Sonia Rodríguez-Ramírez, Juan A Rivera, Simon Barquera, Carolina Batis

Background: Poor diet quality contributes to morbidity and mortality and affects environmental sustainability. The EAT-Lancet reference diet offers a healthy and sustainable solution. This study aimed to estimate the association between diet cost and dietary quality, measured with an EAT-Lancet Index.

Methods: An EAT-Lancet index was adapted to assess adherence to this dietary pattern from 24-h recalls data from the 2012 and 2016 Mexican National Health and Nutrition Surveys (n = 14,242). Prices were obtained from the Consumer Price Index. We dichotomized cost at the median (into low- and high-cost) and compared the EAT-Lancet index scores. We also used multivariate linear regression models to explore the association between diet cost and diet quality.

Results: Individuals consuming a low-cost diet had a higher EAT-Lancet score than those consuming a high-cost diet (20.3 vs. 19.4 from a possible scale of 0 to 42; p < 0.001) due to a lower intake of beef and lamb, pork, poultry, dairy, and added sugars. We found that for each one-point increase in the EAT-Lancet score, there was an average decrease of MXN$0.4 in the diet cost (p < 0.001). This association was only significant among low- and middle-SES individuals.

Conclusions: Contrary to evidence from high-income countries, this study shows that in Mexico, adhering to the EAT-Lancet reference diet is associated with lower dietar costs, particularly in lower SES groups. These findings suggest the potential for broader implementation of healthier diets without increasing the financial burden.

背景:饮食质量差会导致发病率和死亡率,并影响环境的可持续发展。EAT-Lancet 参考膳食提供了一种健康且可持续的解决方案。本研究旨在通过 EAT-Lancet 指数估算饮食成本与饮食质量之间的关系:根据 2012 年和 2016 年墨西哥全国健康与营养调查(n = 14,242 人)中的 24 小时回忆数据,对 EAT-Lancet 指数进行了调整,以评估该饮食模式的坚持情况。价格来自消费者价格指数。我们按中位数对成本进行了二分(分为低成本和高成本),并比较了 EAT-Lancet 指数得分。我们还使用多元线性回归模型来探讨饮食成本与饮食质量之间的关系:结果:与高收入人群相比,低成本饮食人群的 EAT-Lancet 得分更高(从 0 到 42 的评分中,20.3 分对 19.4 分;p 结论:与高收入人群的证据相反,低成本饮食人群的 EAT-Lancet 得分更高(从 0 到 42 的评分中,20.3 分对 19.4 分;p与高收入国家的证据相反,本研究表明,在墨西哥,坚持 EAT-Lancet 参考饮食与较低的饮食成本有关,特别是在社会经济地位较低的群体中。这些研究结果表明,在不增加经济负担的情况下,有可能更广泛地实施更健康的饮食。
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Nutrition Journal
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