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Environmental impact of infant feeding type, accessories used and maternal dietary habits: The GREEN MOTHER-I project, a cross-sectional study protocol. 婴儿喂养类型、所用辅食和母亲饮食习惯对环境的影响:绿色母亲-I 项目,一项横断面研究计划。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-21 DOI: 10.1186/s12937-024-01000-9
Rosa Maria Cabedo-Ferreiro, Liudmila Liutsko, Judit Cos-Busquets, Rosa García-Sierra, Margalida Colldeforns-Vidal, Azahara Reyes-Lacalle, Mª Mercedes Vicente-Hernández, Miriam Gómez-Masvidal, Laura Montero-Pons, Gemma Cazorla-Ortiz, Pere Torán-Monserrat, Concepció Violán, Gemma Falguera-Puig

Introduction: Breastfeeding (BF) is the healthiest form of nutrition for babies and is recommended exclusively (EBF) for at least the first six months of life. The carbon footprint of formula feeding (FF) has been studied, but that of BF is unknown.

Aim: To identify the environmental impact of three types of infant feeding taking into account the accessories needed and the diet of postpartum women in the baby's first month of life.

Methods: This is a multicentre, cross-sectional study conducted in the Barcelona North Metropolitan Area (Catalonia, Spain). The participating sites are primary care settings that will recruit 408 postpartum women (4-6 weeks) as per inclusion/exclusion criteria. The data will be collected through a GREEN MOTHER Survey that includes 4 dimensions: 1) socio-demographic and clinical data; 2) data on the newborn and accessories used in infant feeding; 3) general data on the mother's diet (food consumption habits), and 4) recording of 24 h of the mother's diet. The data analysis will be performed to check the prevalence of infant feeding types at birth and month 1, as well as a comparative analysis of three types of infant feeding on environmental impact (climate change; water consumption, and scarcity).

Ethics: This project was approved by the Research Ethics Committee of the Jordi Gol i Gurina University Institute Foundation for Primary Health Care Research (IDIAP) under code 22/101-P dated 22/02/2023.

Discussion: A second phase of the GREEN MOTHER study is planned, which will consist of an educational intervention to promote breastfeeding, nutrition and sustainability. This intervention will be based on the results obtained in Phase I. We expect that the project results - through the publication and dissemination of scientific papers and reports among relevant stakeholders (association of community midwives, healthcare and primary care attention professionals and the public) - will increase public awareness of breastfeeding and its impact on sustainability.

Trial registration: Both phases of the GREEN MOTHER study protocol were registered in ClinicalTrials.gov, NCT05729581.

导言:母乳喂养(BF)是婴儿最健康的营养方式,建议至少在婴儿出生后的前六个月完全采用母乳喂养(EBF)。目的:考虑到婴儿出生后第一个月所需的配件和产后妇女的饮食,确定三种婴儿喂养方式对环境的影响:这是一项在巴塞罗那北部都市区(西班牙加泰罗尼亚)进行的多中心横断面研究。根据纳入/排除标准,参与研究的基层医疗机构将招募 408 名产后妇女(4-6 周)。数据将通过绿色母亲调查(GREEN MOTHER Survey)收集,该调查包括 4 个方面:1) 社会人口学和临床数据;2) 新生儿和婴儿喂养用品数据;3) 母亲饮食(食物消费习惯)的一般数据;4) 母亲 24 小时饮食记录。数据分析将检查婴儿出生时和满月时的喂养方式的普遍性,以及三种婴儿喂养方式对环境影响(气候变化、耗水量和缺水)的比较分析:伦理:该项目获得了 Jordi Gol i Gurina 大学初级卫生保健研究基金会(IDIAP)研究伦理委员会的批准,批准代码为 22/101-P,批准日期为 2023 年 2 月 22 日:计划开展 "绿色母亲 "研究的第二阶段,其中包括一项旨在促进母乳喂养、营养和可持续性的教育干预措施。我们希望,通过在相关利益方(社区助产士协会、医疗保健和初级保健专业人员以及公众)中发表和传播科学论文和报告,项目成果将提高公众对母乳喂养及其对可持续性影响的认识:绿色母亲 "研究方案的两个阶段均已在 ClinicalTrials.gov NCT05729581 上注册。
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引用次数: 0
Exploring the impact of women-specific reproductive factors on phenotypic aging and the role of life's essential 8. 探索女性特有的生殖因素对表型衰老的影响以及生命中必不可少的 8.
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-20 DOI: 10.1186/s12937-024-00999-1
Xin Zheng, Yue Chen, Shi-Qi Lin, Chen-Ning Liu, Tong Liu, Chen-An Liu, Zi-Wen Wang, Xiao-Yue Liu, Jin-Yu Shi, Zhao-Ting Bu, Hai-Lun Xie, He-Yang Zhang, Hong Zhao, Shu-Qun Li, Xiang-Rui Li, Li Deng, Han-Ping Shi

Background: Aging is an inevitable biological process. Accelerated aging renders adults more susceptible to chronic diseases and increases their mortality rates. Previous studies have reported the relationship between lifestyle factors and phenotypic aging. However, the relationship between intrinsic factors, such as reproductive factors, and phenotypic aging remains unclear.

Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES), spanning from 1999 to 2010 and 2015-2018, with 14,736 adult women. Random forest imputation was used to handle missing covariate values in the final cohort. Weighted linear regression was utilized to analyze the relationship between women-specific reproductive factors and PhenoAgeAccel. Considering the potential impact of menopausal status on the results, additional analyses were conducted on premenopausal and postmenopausal participants. Additionally, the Life's Essential 8 (LE8) was used to investigate the impact of healthy lifestyle and other factors on the relationship between women-specific reproductive factors and PhenoAgeAccel. Stratified analyses were conducted based on significant interaction p-values.

Results: In the fully adjusted models, delayed menarche and gynecological surgery were associated with increased PhenoAgeAccel, whereas pregnancy history were associated with a decrease. Additionally, early or late ages of menopause, first live birth, and last live birth can all negatively impact PhenoAgeAccel. The relationship between women-specific reproductive factors and PhenoAgeAccel differs between premenopausal and postmenopausal women. High LE8 scores positively impacted the relationship between certain reproductive factors (age at menarche, age at menopause, age at first live birth, and age at last live birth) and phenotypic age acceleration. Stratified analysis showed significant interactions for the following variables: BMI with age at menarche, pregnancy history, and age at menopause; ethnicity with age at menopause, age at first live birth, and parity; smoking status with use of contraceptive pills and gynecologic surgery; hypertension with use of contraceptive pills, pregnancy history, and age at menopause.

Conclusion: Delayed menarche, gynecological surgery, and early or late ages of menopause, first live birth, and last live birth are associated with accelerated phenotypic aging. High LE8 score may alleviate the adverse effects of reproductive factors on phenotypic aging.

背景介绍衰老是一个不可避免的生理过程。加速衰老使成年人更容易罹患慢性疾病,并增加其死亡率。以往的研究已报道了生活方式因素与表型衰老之间的关系。然而,生殖因素等内在因素与表型衰老之间的关系仍不清楚:本研究利用了美国国家健康与营养调查(NHANES)的数据,时间跨度为 1999 年至 2010 年和 2015 年至 2018 年,共涉及 14736 名成年女性。采用随机森林归因法处理最终队列中缺失的协变量值。加权线性回归用于分析女性特定生殖因素与 PhenoAgeAccel 之间的关系。考虑到绝经状态对结果的潜在影响,还对绝经前和绝经后的参与者进行了额外的分析。此外,还采用了生活必备 8 项指标(LE8)来研究健康生活方式和其他因素对女性特定生殖因素与 PhenoAgeAccel 之间关系的影响。根据显著的交互作用 p 值进行了分层分析:结果:在完全调整模型中,月经初潮推迟和妇科手术与 PhenoAgeAccel 的增加有关,而妊娠史与 PhenoAgeAccel 的减少有关。此外,绝经年龄过早或过晚、首次活产和最后一次活产都会对 PhenoAgeAccel 产生负面影响。妇女特有的生殖因素与 PhenoAgeAccel 之间的关系在绝经前和绝经后妇女之间有所不同。高 LE8 分数会对某些生殖因素(初潮年龄、绝经年龄、首次活产年龄和最后一次活产年龄)与表型年龄加速度之间的关系产生积极影响。分层分析表明,以下变量之间存在明显的交互作用:体重指数与初潮年龄、妊娠史和绝经年龄有关;种族与绝经年龄、首次活产年龄和胎次有关;吸烟状况与服用避孕药和妇科手术有关;高血压与服用避孕药、妊娠史和绝经年龄有关:结论:初潮延迟、妇科手术、绝经年龄、首次活产年龄和最后一次活产年龄过早或过晚与表型老化加速有关。高 LE8 分值可减轻生殖因素对表型衰老的不利影响。
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引用次数: 0
Dietary antioxidant and inflammatory potential in asthmatic patients and its association with all-cause mortality. 哮喘患者的膳食抗氧化和炎症潜力及其与全因死亡率的关系。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-19 DOI: 10.1186/s12937-024-00994-6
Haixia Zhang, Lina Huang, Yiqing Guo

Background: The occurrence and progression of asthma can be influenced by the components in food. Our study aims to determine whether dietary antioxidant and inflammatory potential are associated with the risk of mortality in asthma patients.

Methods: Participants from the 2001-2018 National Health and Nutrition Examination Survey (NHANES) aged 20 years and older with a diagnosis of asthma were included. Mortality status was obtained according to death certificate records from the National Death Index. The antioxidant and inflammatory potential of the diet was assessed using two widely used and dependable indices, Composite Dietary Antioxidant Index (CDAI) and Dietary Inflammatory Index (DII). Restricted cubic spline (RCS) regression was used to analyze the non-linear relationship between the two indexes and mortality. Multivariable Cox proportional risk models were used to estimate hazard ratio and 95% confidence intervals for mortality. Finally, the relationship between CDAI and DII was analyzed.

Results: A total of 4698 NHANES participants represented 23.2 million non-institutionalized residents of the US were enrolled in our study. Patients with higher CDAI or lower DII exhibited longer survival times. RCS regression showed a linear relationship of CDAI or DII with mortality. In the Cox regression, both crude and adjusted models demonstrated that higher CDAI or lower DII was linked to a reduced risk of all-cause mortality. Similar associations were found in subgroup analysis. Finally, a negative relationship was found between CDAI and DII.

Conclusion: Reducing pro-inflammatory or increasing antioxidant diets could reduce all-cause mortality among adult asthma patients.

背景:哮喘的发生和发展可能受到食物成分的影响。我们的研究旨在确定膳食中的抗氧化剂和炎症潜力是否与哮喘患者的死亡风险有关:方法:纳入 2001-2018 年美国国家健康与营养调查(NHANES)中 20 岁及以上诊断为哮喘的参与者。死亡率状况根据国家死亡指数中的死亡证明记录获得。膳食的抗氧化性和炎症潜力是通过两个广泛使用且可靠的指数来评估的,即膳食抗氧化综合指数(CDAI)和膳食炎症指数(DII)。限制立方样条(RCS)回归用于分析这两个指数与死亡率之间的非线性关系。多变量 Cox 比例风险模型用于估算死亡率的危险比和 95% 的置信区间。最后,分析了 CDAI 和 DII 之间的关系:共有 4698 名 NHANES 参与者参加了我们的研究,他们代表了 2320 万美国非住院居民。CDAI 较高或 DII 较低的患者生存时间较长。RCS 回归显示 CDAI 或 DII 与死亡率呈线性关系。在 Cox 回归中,粗略模型和调整模型均显示,CDAI 较高或 DII 较低的患者全因死亡风险较低。在亚组分析中也发现了类似的关联。最后,CDAI 和 DII 之间呈负相关:结论:减少促炎症饮食或增加抗氧化饮食可降低成年哮喘患者的全因死亡率。
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引用次数: 0
Socioeconomic inequality in breakfast skipping among Norwegian adolescents. 挪威青少年不吃早餐的社会经济不平等现象。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-16 DOI: 10.1186/s12937-024-00998-2
Ingrid Marie Hovdenak, Arnfinn Helleve, Ida Emilie Wolden, Elling Bere

Background: Skipping breakfast is associated with negative health-related and school-related outcomes. Breakfast is the most frequently skipped meal among adolescents. Thus, there is a need to explore the reasons for breakfast skipping across population subgroups to better inform policy makers. The purpose of this study was to present the prevalence of adolescents skipping breakfast on schooldays, analyse the reasons for skipping breakfast and assess associations between the prevalence of skipping breakfast and the reasons for skipping breakfast according to sociodemographic variables.

Methods: The data of a random sample of 10 000 upper secondary school students (aged 16-18 years) from Viken County, Norway, were collected. Students completed a questionnaire measuring breakfast skipping, reasons for skipping breakfast, and sociodemographic variables. Chi-square tests were used to assess differences between the independent groups (family affluence scale (FAS), parental education, and gender) and skipping breakfast and reasons for skipping breakfast.

Results: 22% of adolescents reported that they usually skipped breakfast on all schooldays. Skipping breakfast was more prevalent among females, older students, students with lower socioeconomic status and students in vocational education programmes. The difference in breakfast skipping between students with low and high FAS scores was 31% versus 16%, respectively. The most common self-reported reasons for skipping breakfast were time (59%) and not wanting to eat breakfast (48%). Furthermore, 9% reported health issues, and 3% reported economic constraints as a reason for skipping breakfast. Not wanting to eat breakfast was related to a higher FAS score, health issues were more common among girls, and economic constraints were more common among those with low socioeconomic status.

Conclusions: Skipping breakfast was common among Norwegian upper secondary school students. Lack of time and not wanting breakfast were clearly the most cited reasons for skipping breakfast. Health issues and economic constraints were also cited but were less common. The results showed diverging associations between different demographic characteristics and reasons for skipping breakfast. These results are important for developing effective programs to improve diet among adolescents.

背景:不吃早餐会对健康和学习造成负面影响。早餐是青少年最常不吃的一餐。因此,有必要探讨不同人群不吃早餐的原因,以便为政策制定者提供更好的信息。本研究旨在介绍青少年在上学日不吃早餐的普遍程度,分析不吃早餐的原因,并根据社会人口学变量评估不吃早餐的普遍程度与不吃早餐的原因之间的关联:方法:随机抽样收集了挪威维肯县 10,000 名高中学生(16-18 岁)的数据。学生们填写了一份问卷,调查不吃早餐的情况、不吃早餐的原因以及社会人口变量。我们使用卡方检验来评估独立组别(家庭富裕程度量表(FAS)、父母教育程度和性别)与不吃早餐及不吃早餐原因之间的差异。不吃早餐的现象在女性、高年级学生、社会经济地位较低的学生和职业教育课程学生中更为普遍。FAS 分数较低和较高的学生不吃早餐的比例分别为 31% 和 16%。不吃早餐最常见的自我报告原因是时间(59%)和不想吃早餐(48%)。此外,有 9% 的人称健康问题和 3% 的人称经济拮据是不吃早餐的原因。不想吃早餐与FAS得分较高有关,健康问题在女孩中更为常见,而经济限制在社会经济地位较低的人中更为常见:不吃早餐在挪威高中生中很普遍。缺乏时间和不想吃早餐显然是不吃早餐的最主要原因。健康问题和经济限制也是不吃早餐的原因,但不太常见。研究结果表明,不同的人口特征与不吃早餐的原因之间存在不同的关联。这些结果对于制定改善青少年饮食的有效计划非常重要。
{"title":"Socioeconomic inequality in breakfast skipping among Norwegian adolescents.","authors":"Ingrid Marie Hovdenak, Arnfinn Helleve, Ida Emilie Wolden, Elling Bere","doi":"10.1186/s12937-024-00998-2","DOIUrl":"10.1186/s12937-024-00998-2","url":null,"abstract":"<p><strong>Background: </strong>Skipping breakfast is associated with negative health-related and school-related outcomes. Breakfast is the most frequently skipped meal among adolescents. Thus, there is a need to explore the reasons for breakfast skipping across population subgroups to better inform policy makers. The purpose of this study was to present the prevalence of adolescents skipping breakfast on schooldays, analyse the reasons for skipping breakfast and assess associations between the prevalence of skipping breakfast and the reasons for skipping breakfast according to sociodemographic variables.</p><p><strong>Methods: </strong>The data of a random sample of 10 000 upper secondary school students (aged 16-18 years) from Viken County, Norway, were collected. Students completed a questionnaire measuring breakfast skipping, reasons for skipping breakfast, and sociodemographic variables. Chi-square tests were used to assess differences between the independent groups (family affluence scale (FAS), parental education, and gender) and skipping breakfast and reasons for skipping breakfast.</p><p><strong>Results: </strong>22% of adolescents reported that they usually skipped breakfast on all schooldays. Skipping breakfast was more prevalent among females, older students, students with lower socioeconomic status and students in vocational education programmes. The difference in breakfast skipping between students with low and high FAS scores was 31% versus 16%, respectively. The most common self-reported reasons for skipping breakfast were time (59%) and not wanting to eat breakfast (48%). Furthermore, 9% reported health issues, and 3% reported economic constraints as a reason for skipping breakfast. Not wanting to eat breakfast was related to a higher FAS score, health issues were more common among girls, and economic constraints were more common among those with low socioeconomic status.</p><p><strong>Conclusions: </strong>Skipping breakfast was common among Norwegian upper secondary school students. Lack of time and not wanting breakfast were clearly the most cited reasons for skipping breakfast. Health issues and economic constraints were also cited but were less common. The results showed diverging associations between different demographic characteristics and reasons for skipping breakfast. These results are important for developing effective programs to improve diet among adolescents.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11328473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis. 牛磺酸对心血管的益处:系统回顾和荟萃分析。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-15 DOI: 10.1186/s12937-024-00995-5
Chih-Chen Tzang, Wei-Chen Lin, Long-Huei Lin, Ting-Yu Lin, Ke-Vin Chang, Wei-Ting Wu, Levent Özçakar

Background: Cardiovascular disease (CVD) remains the foremost cause of mortality globally. Taurine, an amino acid, holds promise for cardiovascular health through mechanisms such as calcium regulation, blood pressure reduction, and antioxidant and anti-inflammatory effects. Despite these potential benefits, previous studies have yielded inconsistent results. This meta-analysis of randomized controlled trials (RCTs) aims to evaluate the existing evidence on the quantitative effects of taurine on hemodynamic parameters and cardiac function grading, which are indicative of overall cardiovascular health and performance.

Methods: We conducted an electronic search across multiple databases, including Embase, PubMed, Web of Science, Cochrane CENTRAL, and ClinicalTrials.gov, from their inception to January 2, 2024. Our analysis focused on key cardiovascular outcomes, such as heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular ejection fraction (LVEF), and New York Heart Association (NYHA) Functional Classification. Meta-regression was applied to explore dose-dependent relationships based on the total taurine dose administered during the treatment period. A subgroup analysis, stratified according to the baseline disease status of patients, was also conducted.

Results: The analysis included a pooled sample of 808 participants from 20 randomized controlled trials. Taurine demonstrated a significant reduction in HR (weighted mean difference [WMD] = -3.579 bpm, 95% confidence interval [CI] = -6.044 to -1.114, p = 0.004), SBP (WMD = -3.999 mm Hg, 95% CI = -7.293 to -0.706, p = 0.017), DBP (WMD: -1.435 mm Hg, 95% CI: -2.484 to -0.386, p = 0.007), NYHA (WMD: -0.403, 95% CI: -0.522 to -0.283, p < 0.001), and a significant increase in LVEF (WMD: 4.981%, 95% CI: 1.556 to 8.407, p = 0.004). Meta-regression indicated a dose-dependent reduction in HR (coefficient = -0.0150 per g, p = 0.333), SBP (coefficient = -0.0239 per g, p = 0.113), DBP (coefficient = -0.0089 per g, p = 0.110), and NYHA (coefficient = -0.0016 per g, p = 0.111), and a positive correlation with LVEF (coefficient = 0.0285 per g, p = 0.308). No significant adverse effects were observed compared to controls. In subgroup analysis, taurine significantly improved HR in heart failure patients and healthy individuals. Taurine significantly reduced SBP in healthy individuals, heart failure patients, and those with other diseases, while significantly lowered DBP in hypertensive patients It notably increased LVEF in heart failure patients and improved NYHA functional class in both heart failure patients and those with other diseases.

Conclusions: Taurine showed noteworthy effects in preventing hypertension and enhancing cardiac function. Individuals prone to CVDs may find it advantageous to include taurine in their daily regimen.

背景:心血管疾病(CVD)仍然是全球死亡的首要原因。牛磺酸是一种氨基酸,可通过钙调节、降血压、抗氧化和抗炎作用等机制促进心血管健康。尽管牛磺酸具有这些潜在的益处,但以往的研究结果并不一致。这项随机对照试验(RCTs)的荟萃分析旨在评估牛磺酸对血液动力学参数和心脏功能分级的定量影响的现有证据,这些参数和分级是整体心血管健康和性能的指标:我们在多个数据库(包括 Embase、PubMed、Web of Science、Cochrane CENTRAL 和 ClinicalTrials.gov)中进行了电子检索,检索时间从开始到 2024 年 1 月 2 日。我们的分析侧重于主要的心血管结果,如心率(HR)、收缩压(SBP)、舒张压(DBP)、左心室射血分数(LVEF)和纽约心脏协会(NYHA)功能分类。根据治疗期间的牛磺酸总剂量,采用元回归法探索剂量依赖关系。此外,还根据患者的基线疾病状况进行了亚组分析:分析包括来自 20 项随机对照试验的 808 名参与者。牛磺酸能显著降低心率(加权平均差 [WMD] = -3.579 bpm,95% 置信区间 [CI] = -6.044 至 -1.114, p = 0.004)、血压(WMD = -3.999毫米汞柱,95% 置信区间 = -7.293 至 -0.706,P = 0.017)、DBP(WMD:-1.435毫米汞柱,95% 置信区间:-2.484 至 -0.386,P = 0.007)、NYHA(WMD:-0.403,95% 置信区间:-0.522 至 -0.283,P 结论:牛磺酸对心血管疾病有显著疗效:牛磺酸在预防高血压和增强心脏功能方面具有显著效果。容易患心血管疾病的人可能会发现,在日常饮食中加入牛磺酸是有好处的。
{"title":"Insights into the cardiovascular benefits of taurine: a systematic review and meta-analysis.","authors":"Chih-Chen Tzang, Wei-Chen Lin, Long-Huei Lin, Ting-Yu Lin, Ke-Vin Chang, Wei-Ting Wu, Levent Özçakar","doi":"10.1186/s12937-024-00995-5","DOIUrl":"10.1186/s12937-024-00995-5","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease (CVD) remains the foremost cause of mortality globally. Taurine, an amino acid, holds promise for cardiovascular health through mechanisms such as calcium regulation, blood pressure reduction, and antioxidant and anti-inflammatory effects. Despite these potential benefits, previous studies have yielded inconsistent results. This meta-analysis of randomized controlled trials (RCTs) aims to evaluate the existing evidence on the quantitative effects of taurine on hemodynamic parameters and cardiac function grading, which are indicative of overall cardiovascular health and performance.</p><p><strong>Methods: </strong>We conducted an electronic search across multiple databases, including Embase, PubMed, Web of Science, Cochrane CENTRAL, and ClinicalTrials.gov, from their inception to January 2, 2024. Our analysis focused on key cardiovascular outcomes, such as heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular ejection fraction (LVEF), and New York Heart Association (NYHA) Functional Classification. Meta-regression was applied to explore dose-dependent relationships based on the total taurine dose administered during the treatment period. A subgroup analysis, stratified according to the baseline disease status of patients, was also conducted.</p><p><strong>Results: </strong>The analysis included a pooled sample of 808 participants from 20 randomized controlled trials. Taurine demonstrated a significant reduction in HR (weighted mean difference [WMD] = -3.579 bpm, 95% confidence interval [CI] = -6.044 to -1.114, p = 0.004), SBP (WMD = -3.999 mm Hg, 95% CI = -7.293 to -0.706, p = 0.017), DBP (WMD: -1.435 mm Hg, 95% CI: -2.484 to -0.386, p = 0.007), NYHA (WMD: -0.403, 95% CI: -0.522 to -0.283, p < 0.001), and a significant increase in LVEF (WMD: 4.981%, 95% CI: 1.556 to 8.407, p = 0.004). Meta-regression indicated a dose-dependent reduction in HR (coefficient = -0.0150 per g, p = 0.333), SBP (coefficient = -0.0239 per g, p = 0.113), DBP (coefficient = -0.0089 per g, p = 0.110), and NYHA (coefficient = -0.0016 per g, p = 0.111), and a positive correlation with LVEF (coefficient = 0.0285 per g, p = 0.308). No significant adverse effects were observed compared to controls. In subgroup analysis, taurine significantly improved HR in heart failure patients and healthy individuals. Taurine significantly reduced SBP in healthy individuals, heart failure patients, and those with other diseases, while significantly lowered DBP in hypertensive patients It notably increased LVEF in heart failure patients and improved NYHA functional class in both heart failure patients and those with other diseases.</p><p><strong>Conclusions: </strong>Taurine showed noteworthy effects in preventing hypertension and enhancing cardiac function. Individuals prone to CVDs may find it advantageous to include taurine in their daily regimen.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11325608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal methods of vitamin D supplementation to prevent acute respiratory infections: a systematic review, dose-response and pairwise meta-analysis of randomized controlled trials. 预防急性呼吸道感染的最佳维生素 D 补充方法:随机对照试验的系统回顾、剂量反应和配对荟萃分析。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-14 DOI: 10.1186/s12937-024-00990-w
Chih-Hung Wang, Lorenzo Porta, Ting-Kai Yang, Yu-Hsiang Wang, Tsung-Hung Wu, Frank Qian, Yin-Yi Han, Wang-Huei Sheng, Shyr-Chyr Chen, Chien-Chang Lee, Shan-Chwen Chang

Background: Vitamin D supplementation may prevent acute respiratory infections (ARIs). This study aimed to identify the optimal methods of vitamin D supplementation.

Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science, and the ClinicalTrials.gov registry were searched from database inception through July 13, 2023. Randomized-controlled trials (RCTs) were included. Data were pooled using random-effects model. The primary outcome was the proportion of participants with one or more ARIs.

Results: The analysis included 43 RCTs with 49320 participants. Forty RCTs were considered to be at low risk for bias. The main pairwise meta-analysis indicated there were no significant preventive effects of vitamin D supplementation against ARIs (risk ratio [RR]: 0.99, 95% confidence interval [CI]: 0.97 to 1.01, I2 = 49.6%). The subgroup dose-response meta-analysis indicated that the optimal vitamin D supplementation doses ranged between 400-1200 IU/day for both summer-sparing and winter-dominant subgroups. The subgroup pairwise meta-analysis also revealed significant preventive effects of vitamin D supplementation in subgroups of daily dosing (RR: 0.92, 95% CI: 0.85 to 0.99, I2 = 55.7%, number needed to treat [NNT]: 36), trials duration < 4 months (RR: 0.81, 95% CI: 0.67 to 0.97, I2 = 48.8%, NNT: 16), summer-sparing seasons (RR: 0.85, 95% CI: 0.74 to 0.98, I2 = 55.8%, NNT: 26), and winter-dominant seasons (RR: 0.79, 95% CI: 0.71 to 0.89, I2 = 9.7%, NNT: 10).

Conclusion: Vitamin D supplementation may slightly prevent ARIs when taken daily at doses between 400 and 1200 IU/d during spring, autumn, or winter, which should be further examined in future clinical trials.

背景:补充维生素 D 可预防急性呼吸道感染(ARI):补充维生素 D 可预防急性呼吸道感染(ARI)。本研究旨在确定补充维生素 D 的最佳方法:方法:对 PubMed、Embase、Cochrane Central Register of Controlled Trials、Web of Science 和 ClinicalTrials.gov 注册表进行了检索,检索时间从数据库开始至 2023 年 7 月 13 日。纳入了随机对照试验(RCT)。采用随机效应模型对数据进行了汇总。主要结果是出现一次或多次ARI的参与者比例:分析包括 43 项随机对照试验,共有 49320 名参与者。40项研究被认为偏倚风险较低。主要的配对荟萃分析表明,补充维生素 D 对预防急性呼吸道感染没有显著效果(风险比 [RR]:0.99,95% 置信区间:0.99,95% 置信区间:0.99):0.99,95% 置信区间 [CI]:0.97至1.01,I2 = 49.6%)。亚组剂量-反应荟萃分析表明,夏季和冬季亚组的最佳维生素 D 补充剂量介于 400-1200 IU/天之间。亚组配对荟萃分析还显示,在每日剂量的亚组中,维生素 D 补充剂具有显著的预防效果(RR:0.92,95% CI:0.85 至 0.99,I2 = 55.7%,治疗所需人数 [NNT]:结论:维生素 D 补充剂可轻微缓解甲状腺肿大(RR:0.92,95% CI:0.85 至 0.99,I2 = 55.7%,治疗所需人数[NNT]:36)、试验持续时间 2 = 48.8%,NNT:16)、夏季缓解季节(RR:0.85,95% CI:0.74 至 0.98,I2 = 55.8%,治疗所需人数[NNT]:26)和冬季缓解季节(RR:0.79,95% CI:0.71 至 0.89,I2 = 9.7%,治疗所需人数[NNT]:10):结论:在春季、秋季或冬季,每天服用 400 至 1200 IU 的维生素 D 补充剂可轻微预防急性呼吸道感染。
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引用次数: 0
Association between dietary diversity changes and frailty among Chinese older adults: findings from a nationwide cohort study. 中国老年人膳食多样性变化与虚弱之间的关系:一项全国性队列研究的结果。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-13 DOI: 10.1186/s12937-024-00997-3
Xiao-Meng Wang, Wen-Fang Zhong, Yi-Tian Zhang, Jia-Xuan Xiang, Huan Chen, Zhi-Hao Li, Qiao-Qiao Shen, Dong Shen, Wei-Qi Song, Qi Fu, Jian Gao, Zi-Ting Chen, Chuan Li, Jia-Hao Xie, Dan Liu, Yue-Bin Lv, Xiao-Ming Shi, Chen Mao

Background: Dietary diversity has been suggested as a potential preventive measure against frailty in older adults, but the effect of changes in dietary diversity on frailty is unclear. This study was conducted to examine the association between the dietary diversity score (DDS) and frailty among older Chinese adults.

Methods: A total of 12,457 adults aged 65 years or older were enrolled from three consecutive and nonoverlapping cohorts from the Chinese Longitudinal Healthy Longevity Survey (the 2002 cohort, the 2005 cohort, and the 2008 cohort). DDS was calculated based on nine predefined food groups, and DDS changes were assessed by comparing scores at baseline and the first follow-up survey. We used 39 self-reported health items to assess frailty. Cox proportional hazard models were performed to examine the association between DDS change patterns and frailty.

Results: Participants with low-to-low DDS had the highest frailty incidence (111.1/1000 person-years), while high-to-high DDS had the lowest (41.1/1000 person-years). Compared to the high-to-high group of overall DDS pattern, participants in other DDS change patterns had a higher risk of frailty (HRs ranged from 1.25 to 2.15). Similar associations were observed for plant-based and animal-based DDS. Compared to stable DDS changes, participants with an extreme decline in DDS had an increased risk of frailty, with HRs of 1.38 (1.24, 1.53), 1.31 (1.19, 1.44), and 1.29 (1.16, 1.43) for overall, plant-based, and animal-based DDS, respectively.

Conclusions: Maintaining a lower DDS or having a large reduction in DDS was associated with a higher risk of frailty among Chinese older adults. These findings highlight the importance of improving a diverse diet across old age for preventing frailty in later life.

背景:膳食多样性被认为是预防老年人体弱的潜在措施,但膳食多样性的变化对体弱的影响尚不清楚。本研究旨在探讨中国老年人膳食多样性评分(DDS)与虚弱之间的关系:方法:从中国健康长寿纵向调查的三个连续且不重叠的队列(2002 年队列、2005 年队列和 2008 年队列)中选取了 12457 名 65 岁及以上的成年人。DDS根据九种预定义的食物类别进行计算,并通过比较基线和首次随访调查时的得分来评估DDS的变化。我们使用 39 个自我报告的健康项目来评估虚弱程度。我们采用 Cox 比例危险模型来研究 DDS 变化模式与虚弱之间的关系:结果:DDS从低到低的参与者虚弱发生率最高(111.1/1000人年),而DDS从高到高的参与者虚弱发生率最低(41.1/1000人年)。与整体DDS模式从高到高组相比,其他DDS变化模式的参与者罹患虚弱的风险更高(HR值介于1.25到2.15之间)。在植物性和动物性DDS中也观察到了类似的关联。与稳定的DDS变化相比,DDS极度下降的参与者罹患虚弱的风险更高,总体、植物性和动物性DDS的HR值分别为1.38(1.24,1.53)、1.31(1.19,1.44)和1.29(1.16,1.43):保持较低的 DDS 或 DDS 大幅下降与中国老年人较高的虚弱风险有关。这些发现凸显了改善老年人多样化饮食对预防晚年虚弱的重要性。
{"title":"Association between dietary diversity changes and frailty among Chinese older adults: findings from a nationwide cohort study.","authors":"Xiao-Meng Wang, Wen-Fang Zhong, Yi-Tian Zhang, Jia-Xuan Xiang, Huan Chen, Zhi-Hao Li, Qiao-Qiao Shen, Dong Shen, Wei-Qi Song, Qi Fu, Jian Gao, Zi-Ting Chen, Chuan Li, Jia-Hao Xie, Dan Liu, Yue-Bin Lv, Xiao-Ming Shi, Chen Mao","doi":"10.1186/s12937-024-00997-3","DOIUrl":"10.1186/s12937-024-00997-3","url":null,"abstract":"<p><strong>Background: </strong>Dietary diversity has been suggested as a potential preventive measure against frailty in older adults, but the effect of changes in dietary diversity on frailty is unclear. This study was conducted to examine the association between the dietary diversity score (DDS) and frailty among older Chinese adults.</p><p><strong>Methods: </strong>A total of 12,457 adults aged 65 years or older were enrolled from three consecutive and nonoverlapping cohorts from the Chinese Longitudinal Healthy Longevity Survey (the 2002 cohort, the 2005 cohort, and the 2008 cohort). DDS was calculated based on nine predefined food groups, and DDS changes were assessed by comparing scores at baseline and the first follow-up survey. We used 39 self-reported health items to assess frailty. Cox proportional hazard models were performed to examine the association between DDS change patterns and frailty.</p><p><strong>Results: </strong>Participants with low-to-low DDS had the highest frailty incidence (111.1/1000 person-years), while high-to-high DDS had the lowest (41.1/1000 person-years). Compared to the high-to-high group of overall DDS pattern, participants in other DDS change patterns had a higher risk of frailty (HRs ranged from 1.25 to 2.15). Similar associations were observed for plant-based and animal-based DDS. Compared to stable DDS changes, participants with an extreme decline in DDS had an increased risk of frailty, with HRs of 1.38 (1.24, 1.53), 1.31 (1.19, 1.44), and 1.29 (1.16, 1.43) for overall, plant-based, and animal-based DDS, respectively.</p><p><strong>Conclusions: </strong>Maintaining a lower DDS or having a large reduction in DDS was associated with a higher risk of frailty among Chinese older adults. These findings highlight the importance of improving a diverse diet across old age for preventing frailty in later life.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11320915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141976251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary niacin Intake and its association with all-cause and cardiovascular mortality rates in individuals with metabolic syndrome. 代谢综合征患者的膳食烟酸摄入量及其与全因死亡率和心血管死亡率的关系。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-10 DOI: 10.1186/s12937-024-00993-7
Yuqing Fu, Cong Xu, Guifu Wu

Background: Individuals with metabolic syndrome face elevated cardiovascular and mortality risks, and there is ongoing debate regarding the cardiovascular effects of niacin and its impact on the prognosis of metabolic syndrome.

Exposure: Levels of dietary niacin intake based on 24-hour dietary recall.

Methods: Kaplan-Meier survival curves were used to compare survival status among quartiles of dietary niacin intake. Weighted Cox proportional hazards models and restricted cubic splines were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of all-cause and CVD mortality associated with the exposure.

Results: This cohort study included 8,744 participants, and during a median follow-up period of 106 months, 1,552 (17.7%) deaths were recorded, with 511 attributed to cardiovascular disease. Kaplan-Meier curves comparing quartiles of dietary niacin intake showed significant differences in both all-cause and cardiovascular mortality rates (log-rank p < 0.001). In the fully adjusted model, the highest quartile of dietary niacin intake was associated with HRs of 0.68 (95% CI: 0.54, 0.87, P = 0.002) for all-cause mortality and 0.63 (95% CI: 0.39, 0.78, P < 0.001) for cardiovascular mortality.

Conclusion: The results of this cohort study suggest that higher dietary niacin intake is associated with reduced cardiovascular and all-cause mortality risks in the metabolic syndrome population. Furthermore, there appears to be a dose-response relationship between dietary niacin intake and the risks of all-cause and cardiovascular mortality.

背景:代谢综合征患者面临着较高的心血管风险和死亡风险,关于烟酸对心血管的影响及其对代谢综合征预后的影响一直存在争议:暴露:基于 24 小时膳食回忆的膳食烟酸摄入水平:方法:采用卡普兰-梅耶生存曲线比较膳食烟酸摄入量四分位数的生存状况。采用加权 Cox 比例危险模型和限制性立方样条来估计与暴露相关的全因和心血管疾病死亡风险的危险比 (HR) 和 95% 置信区间 (CI):这项队列研究包括 8744 名参与者,在中位 106 个月的随访期间,共记录了 1552 例(17.7%)死亡病例,其中 511 例死于心血管疾病。比较膳食中烟酸摄入量四分位数的 Kaplan-Meier 曲线显示,全因死亡率和心血管疾病死亡率均存在显著差异(对数rank p 结论:膳食中烟酸摄入量四分位数与心血管疾病死亡率之间存在显著差异:这项队列研究的结果表明,膳食中烟酸摄入量越高,代谢综合征人群的心血管和全因死亡率风险就越低。此外,膳食烟酸摄入量与全因和心血管死亡风险之间似乎存在剂量反应关系。
{"title":"Dietary niacin Intake and its association with all-cause and cardiovascular mortality rates in individuals with metabolic syndrome.","authors":"Yuqing Fu, Cong Xu, Guifu Wu","doi":"10.1186/s12937-024-00993-7","DOIUrl":"10.1186/s12937-024-00993-7","url":null,"abstract":"<p><strong>Background: </strong>Individuals with metabolic syndrome face elevated cardiovascular and mortality risks, and there is ongoing debate regarding the cardiovascular effects of niacin and its impact on the prognosis of metabolic syndrome.</p><p><strong>Exposure: </strong>Levels of dietary niacin intake based on 24-hour dietary recall.</p><p><strong>Methods: </strong>Kaplan-Meier survival curves were used to compare survival status among quartiles of dietary niacin intake. Weighted Cox proportional hazards models and restricted cubic splines were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of all-cause and CVD mortality associated with the exposure.</p><p><strong>Results: </strong>This cohort study included 8,744 participants, and during a median follow-up period of 106 months, 1,552 (17.7%) deaths were recorded, with 511 attributed to cardiovascular disease. Kaplan-Meier curves comparing quartiles of dietary niacin intake showed significant differences in both all-cause and cardiovascular mortality rates (log-rank p < 0.001). In the fully adjusted model, the highest quartile of dietary niacin intake was associated with HRs of 0.68 (95% CI: 0.54, 0.87, P = 0.002) for all-cause mortality and 0.63 (95% CI: 0.39, 0.78, P < 0.001) for cardiovascular mortality.</p><p><strong>Conclusion: </strong>The results of this cohort study suggest that higher dietary niacin intake is associated with reduced cardiovascular and all-cause mortality risks in the metabolic syndrome population. Furthermore, there appears to be a dose-response relationship between dietary niacin intake and the risks of all-cause and cardiovascular mortality.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316429/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of serum 25-hydroxyvitamin D concentrations with all-cause and cause-specific mortality among individuals with gout and hyperuricemia. 痛风和高尿酸血症患者血清中 25- 羟维生素 D 浓度与全因和特定原因死亡率的关系。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-09 DOI: 10.1186/s12937-024-00992-8
Ke Liu, Xuanni Lu, Anqi Wang, Weiwei Chen, Ying Chen, Jiayu Li, Xiaohui Sun, Lin Huang, Zhixing He, Chengping Wen, Yingying Mao, Ding Ye

Background: We aimed to probe the association of serum 25-hydroxyvitamin D [25(OH)D] concentrations with all-cause and cause-specific mortality among patients with gout and hyperuricemia (HUA).

Methods: The study included 1169 gout patients and 7029 HUA patients from the National Health and Nutrition Examination Survey (NHANES) 2007-2018 and 2001-2018, respectively. The association between serum 25(OH)D and mortality was evaluated by Cox proportional hazard and restricted cubic spline models.

Results: Among participants with gout and HUA, the weighted mean concentrations of serum 25(OH)D were 71.49 ± 30.09 nmol/L and 64.81 ± 26.92 nmol/L, respectively. Vitamin D deficiency occurred in 29.68% of gout patients and 37.83% of HUA patients. During 6783 person-years of follow-up among gout patients, 248 all-cause deaths occurred, among which 76 died from cardiovascular disease (CVD) and 49 died from cancer. 1375 HUA patients were recorded for all-cause mortality during 59,859 person-years of follow-up, including 427 CVD deaths and 232 cancer deaths. After multifactorial adjustment, per one-unit increment in natural log-transformed 25(OH)D was associated with lower risk of 55% all-cause mortality and 61% CVD mortality among gout patients, and a 45% reduced risk of cancer mortality among HUA patients. Restricted cubic splines showed a U-shaped relationship with all-cause and CVD mortality among HUA patients, with inflection points of 72.7 nmol/L and 38.0 nmol/L, respectively. The results were robust in subgroup and sensitivity analyses.

Conclusions: Serum 25(OH)D was negatively linearly correlated with mortality among gout patients, whereas U-shaped correlated with mortality in HUA patients. These results indicate that adequate vitamin D status could prevent premature death.

背景:我们旨在探究痛风和高尿酸血症(HUA)患者血清25-羟基维生素D[25(OH)D]浓度与全因和特定原因死亡率的关系:研究分别纳入了2007-2018年美国国家健康与营养调查(NHANES)和2001-2018年美国国家健康与营养调查(NHANES)中的1169名痛风患者和7029名高尿酸血症患者。通过Cox比例危险模型和限制性立方样条模型评估了血清25(OH)D与死亡率之间的关系:在痛风和HUA患者中,血清25(OH)D的加权平均浓度分别为71.49 ± 30.09 nmol/L和64.81 ± 26.92 nmol/L。29.68%的痛风患者和37.83%的HUA患者缺乏维生素D。在对痛风患者进行的 6783 人年的随访中,有 248 人死于各种原因,其中 76 人死于心血管疾病(CVD),49 人死于癌症。在59859人年的随访中,1375名HUA患者出现全因死亡,其中427人死于心血管疾病,232人死于癌症。经多因素调整后,25(OH)D自然对数转换后每增加一个单位,痛风患者的全因死亡风险降低55%,心血管疾病死亡风险降低61%,HUA患者的癌症死亡风险降低45%。限制性立方样条曲线显示,HUA 患者的全因死亡率和心血管疾病死亡率呈 U 型关系,拐点分别为 72.7 nmol/L 和 38.0 nmol/L。这些结果在亚组分析和敏感性分析中都是可靠的:结论:血清 25(OH)D 与痛风患者的死亡率呈负线性相关,而与 HUA 患者的死亡率呈 U 型相关。这些结果表明,充足的维生素D可预防过早死亡。
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引用次数: 0
Methodology and challenges for harmonization of nutritional data from seven historical studies. 统一七项历史研究营养数据的方法和挑战。
IF 4.4 2区 医学 Q1 NUTRITION & DIETETICS Pub Date : 2024-08-06 DOI: 10.1186/s12937-024-00976-8
Sivan Ben Avraham, Angela Chetrit, Nirit Agay, Laurence S Freedman, Walid Saliba, Uri Goldbourt, Lital Keinan-Boker, Ofra Kalter-Leibovici, Danit R Shahar, Lizie Kimron, Rachel Dankner

Background: Collection of detailed dietary data is labor intensive and expensive, harmonization of existing data sets has been proposed as an effective tool for research questions in which individual studies are underpowered.

Methods: In this paper, we describe the methodology used to retrospectively harmonize nutritional data from multiple sources, based on the individual participant data of all available studies, which collected nutritional data in Israel between 1963 and 2014. This collaboration was established in order to study the association of red and processed meat with colorectal cancer. Two types of nutritional questionnaires, the Food Frequency Questionnaires (FFQ) and the 24-h dietary recall (24HR recall), and different food composition tables, were used by the participating studies. The main exposure of interest included type of meat (total meat, red meat, and poultry) and level of processing.

Results: A total of 29,560 Israeli men and women were enrolled. In studies using FFQ,the weighted mean intakes of total, red, processed meat, and poultry were 95, 27, 37 and 58 gr/day and 92, 25, 10, and 66 gr/day in studies using 24HR recall, respectively.. Despite several methodological challenges, we successfully harmonized nutritional data from the different studies.

Conclusions: This paper emphasizes the significance and feasibility of harmonization of previously collected nutritional data, offering an opportunity to examine associations between a range of dietary exposures and the outcome of interest, while minimizing costs and time in epidemiological studies.

背景:收集详细的膳食数据既费力又昂贵:收集详细的膳食数据耗费大量人力和财力,因此,对于单项研究力量不足的研究问题,协调现有数据集被认为是一种有效的工具:在本文中,我们介绍了根据所有可用研究的个人参与者数据,对多个来源的营养数据进行回顾性协调的方法,这些研究在 1963 年至 2014 年期间在以色列收集了营养数据。这项合作是为了研究红肉和加工肉类与结直肠癌的关系。参与研究使用了两种营养问卷,即食物频率问卷(FFQ)和24小时饮食回忆(24HR recall),以及不同的食物成分表。主要研究对象包括肉类种类(全肉、红肉和禽肉)和加工程度:共有 29 560 名以色列男性和女性参加了研究。在使用 FFQ 的研究中,总肉、红肉、加工肉和家禽的加权平均摄入量分别为 95、27、37 和 58 克/天;在使用 24 小时回忆的研究中,总肉、红肉、加工肉和家禽的加权平均摄入量分别为 92、25、10 和 66 克/天。尽管在方法上存在一些挑战,但我们成功地协调了来自不同研究的营养数据:本文强调了统一以前收集的营养数据的意义和可行性,为研究一系列膳食暴露与相关结果之间的关系提供了机会,同时最大限度地减少了流行病学研究的成本和时间。
{"title":"Methodology and challenges for harmonization of nutritional data from seven historical studies.","authors":"Sivan Ben Avraham, Angela Chetrit, Nirit Agay, Laurence S Freedman, Walid Saliba, Uri Goldbourt, Lital Keinan-Boker, Ofra Kalter-Leibovici, Danit R Shahar, Lizie Kimron, Rachel Dankner","doi":"10.1186/s12937-024-00976-8","DOIUrl":"10.1186/s12937-024-00976-8","url":null,"abstract":"<p><strong>Background: </strong>Collection of detailed dietary data is labor intensive and expensive, harmonization of existing data sets has been proposed as an effective tool for research questions in which individual studies are underpowered.</p><p><strong>Methods: </strong>In this paper, we describe the methodology used to retrospectively harmonize nutritional data from multiple sources, based on the individual participant data of all available studies, which collected nutritional data in Israel between 1963 and 2014. This collaboration was established in order to study the association of red and processed meat with colorectal cancer. Two types of nutritional questionnaires, the Food Frequency Questionnaires (FFQ) and the 24-h dietary recall (24HR recall), and different food composition tables, were used by the participating studies. The main exposure of interest included type of meat (total meat, red meat, and poultry) and level of processing.</p><p><strong>Results: </strong>A total of 29,560 Israeli men and women were enrolled. In studies using FFQ,the weighted mean intakes of total, red, processed meat, and poultry were 95, 27, 37 and 58 gr/day and 92, 25, 10, and 66 gr/day in studies using 24HR recall, respectively.. Despite several methodological challenges, we successfully harmonized nutritional data from the different studies.</p><p><strong>Conclusions: </strong>This paper emphasizes the significance and feasibility of harmonization of previously collected nutritional data, offering an opportunity to examine associations between a range of dietary exposures and the outcome of interest, while minimizing costs and time in epidemiological studies.</p>","PeriodicalId":19203,"journal":{"name":"Nutrition Journal","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11302319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Nutrition Journal
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