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Influence of the internalization of beauty ideals, depressive symptoms, body mass index, and type of university on disordered eating behaviors in university students in Mexico City. 美的理想内化、抑郁症状、体重指数和大学类型对墨西哥城大学生饮食失调行为的影响
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-02-27 DOI: 10.20960/nh.05908
Claudia Unikel Santoncini, Maricarmen Díaz Gutiérrez, Miriam Wendolyn Barajas Márquez, Alicia Parra Carriedo, Concepción Díaz de León Vázquez, José Alberto Rivera Márquez, Gladys Bilbao Y Morcelle

Introduction: Background: disordered eating behaviors (DEBs) encompass altered eating behaviors that do not meet the diagnostic criteria to be considered eating disorders, yet, like the latter, are associated with multiple medical, psychological, and social complications. Objective: this study aimed to analyze the influence of the internalization of beauty ideals (specifically thinness and muscularity), depressive symptoms, body mass index (BMI), and type of university on DEBs. Methods: a correlational, cross-sectional study was conducted with two independent samples of university students from two universities, one public and one private, in Mexico City (n = 1571; 20.8  2.07 years). Data analysis included frequency and percentage estimation, mean comparison, and linear regression analysis. Results: students enrolled at the private university scored higher for all the variables studied, with statistically significant differences, except for BMI, where public university students scored higher. When compared by BMI, overweight and obese students scored higher for DEBs and internalization. In women, DEBs were predicted by thin-ideal internalization, BMI, and type of university. In male participants, predictors included BMI, depressive symptoms, and type of university. Conclusions: the results confirmed previous findings in the literature, with socioeconomic status being a determining factor for the presence of DEBs.

背景:饮食失调行为(DEBs)包括不符合饮食失调诊断标准的饮食行为改变,但与后者一样,与多种医学、心理和社会并发症相关。目的:本研究旨在分析美的理想内化(特别是瘦和肌肉)、抑郁症状、身体质量指数(BMI)和大学类型对DEBs的影响。方法:对墨西哥城两所公立和私立大学的两名独立大学生进行相关横断面研究(n = 1571; 20.82.07岁)。数据分析包括频率和百分比估计、均值比较和线性回归分析。结果:私立大学的学生在研究的所有变量中得分都更高,除了BMI,公立大学的学生得分更高,统计学上有显著差异。与BMI相比,超重和肥胖的学生在deb和内化方面得分更高。在女性中,deb通过瘦理想内化、BMI和大学类型来预测。在男性参与者中,预测因素包括身体质量指数、抑郁症状和大学类型。结论:研究结果证实了先前文献中的发现,社会经济地位是DEBs存在的决定性因素。
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引用次数: 0
[Evaluation of the effectiveness of a nutritional support programme in patients with diarrhoea secondary to abdominal and/or pelvic radiotherapy, whether or not associated with other cancer treatments, in radiation oncology departments]. [评估营养支持方案对放射肿瘤科腹部和/或盆腔放疗继发腹泻患者的有效性,无论是否与其他癌症治疗相关]。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-02-27 DOI: 10.20960/nh.05617
Margarita Martín Martín, Laura Ferrera Alayón, Raquel Benlloch, Daniel Melero García, Bárbara Salas-Salas, Sofía Córdoba, Sonsoles Sancho García

Introduction: Introduction: the administration of enteral nutrition formulas with peptides, medium-chain triglycerides and no fibre could mitigate gastrointestinal intolerance in cancer patients with digestive tract involvement. We aim to evaluate the effectiveness, in terms of maintenance or improvement of nutritional status and symptom control, of a nutritional management algorithm, designed by a specialist in endocrinology and nutrition and based on oligomeric oral supplementation, within radiation oncology departments. Patients and methods: we conducted a prospective study in three radiation oncology services with patients diagnosed with tumours treated with radical intention irradiation of the abdominal and/or pelvic area. Bowel function, body composition study, dynamometry and nutritional assessment according to the Subjective Global Assessment (SGA) and Global Leadership Initiative on Malnutrition (GLIM) criteria were evaluated. Results: 120 patients were included, 39 of whom required oral nutritional supplementation. Of these, 43.5 % were severely malnourished at baseline. Seventeen of them received polymeric and 22 oligomeric supplements. Patients who were well nourished at baseline and received oligomeric supplementation maintained this good nutritional status at the end of the study significantly more often than those who received polymeric supplementation. They also showed a decrease in the duration of diarrhoea, 24 vs 35 days (p = 0.047) and better scores on the adherence questionnaires. Conclusion: in patients without malnutrition, early oligomeric supplementation manages to maintain this state in a greater number of cases than polymeric formulas, as well as reducing the duration of diarrhoea.

简介:含多肽、中链甘油三酯和无纤维的肠内营养配方可减轻累及消化道的癌症患者的胃肠道不耐受。我们的目标是评估在维持或改善营养状况和症状控制方面的有效性,由内分泌学和营养学专家设计,基于低聚物口服补充剂,在放射肿瘤科。患者和方法:我们在三种放射肿瘤学服务中进行了一项前瞻性研究,这些患者被诊断患有腹部和/或骨盆区域的根治性放射治疗。根据主观整体评估(SGA)和全球营养不良领导倡议(GLIM)标准对肠道功能、身体成分研究、动力测量和营养评估进行评估。结果:纳入120例患者,其中39例需要口服营养补充。其中43.5%的人在基线时严重营养不良。其中17人服用聚合物补充剂,22人服用低聚物补充剂。在基线时营养良好并接受寡聚物补充剂的患者在研究结束时保持这种良好营养状态的几率明显高于接受聚合物补充剂的患者。他们还显示腹泻持续时间减少,24天和35天(p = 0.047),并且在依从性问卷调查中得分更高。结论:在没有营养不良的患者中,与聚合物配方相比,早期补充低聚物能够在更多的病例中维持这种状态,并缩短腹泻的持续时间。
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引用次数: 0
Effects of immunonutrition on serum albumin, IL-6, and TNF-α levels in patients with COVID-19: a randomized controlled double-blind clinical trial. 免疫营养对COVID-19患者血清白蛋白、IL-6和TNF-α水平的影响:一项随机对照双盲临床试验
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-02-27 DOI: 10.20960/nh.05747
Letícia Costa Lopes, Rodrigo Merces Weyll Pimentel, Arthur Pinto Silva, Amália Ivine Costa Santana, Durval Ribas Filho, Argemiro D'Oliveira Júnior, Dandara Almeida Reis da Silva, Vitória Cesar Santos Gonçalves Brito, André Silva Dos Santos, Sandra Lúcia Fernandes, Isolda Padro de Negreiros Nogueira Maduro, Julita Maria Freitas Coelho, André Luiz Costa Brandão, Marcella Garcez Duarte, Antônio Marcos Tosoli Gomes, Lorena de Carvalho Almeida, Simone Maria de Oliveira Silva, Marcia Cristina Almeida Magalhães, Tatiana Dos Santos Moreira, Nádia Juliana Beraldo Goulart Borges Haubert, Sérgio Queiroz Braga, Caroline da Silva Barbosa, Aritana Alves Pereira, Rejane Macedo de Sousa, Danila Aglae Marques Cabral, Murilo Silva Oliveira, Eline de Almeida Soriano, Kairo Silvestre Meneses Damasceno, Magno Conceição das Merces

Introduction: Background and objectives: many specialized immunonutrient formulas are available, with an emphasis on combining arginine, omega 3 fatty acids, and nucleotides. These nutrients can reduce the inflammatory pattern, with an increased contribution to resolving infections. Considering the inflammatory catharsis resulting from COVID-19, this study aimed to evaluate the effect of immunonutrition on serum albumin, IL-6, and TNF-α levels in patients with COVID-19. Materials and methods: a randomized double-blind clinical trial conducted in 2020 in Salvador, Bahia, Brazil. Adult patients diagnosed with COVID-19 were randomized to receive a standard hyperproteic normocaloric supplement (control) or a supplement enriched with immunonutrients (experiment) for a period of 7 days. The participants were monitored for a period of 8 days, including the assessment of risk and nutritional status, and collection of blood samples to evaluate albumin, IL-6, and TNF-α. Results: 70 patients were included in the study. 64 were randomly allocated to receive an immunonutrient diet or a standard control diet. The nutritional diagnosis was 27.6 (± 0.8) kg/m² and the nutritional risk was 41.9 %. In the experiment group, there was an average increase in albumin to 0.84 (± 0.65) mg/dL, while in the control group this increase was of 0.21 (± 0.52) mg/dL. Regarding the IL-6 doses, there was a reduction both in the experiment group (-257.27 ± 448.89 pg/ml) and in the control group (-142.75 ± 253.29 pg/ml). When comparing the difference in TNF-α levels, a reduction was observed in the experiment group (-3.72 ± 5.98 pg/ml), while an increase in the control group (5.33 ± 10.48 pg/ml) was observed. Conclusions: the use of an oral supplement enriched with immunonutrients seems to be able to reduce the IL-6 and TNF-α serum levels and increase serum albumin levels.

背景和目的:有许多专门的免疫营养配方,重点是结合精氨酸、欧米伽3脂肪酸和核苷酸。这些营养物质可以减少炎症模式,对解决感染有更大的贡献。考虑到COVID-19引起的炎症性宣泄,本研究旨在评估免疫营养对COVID-19患者血清白蛋白、IL-6和TNF-α水平的影响。材料和方法:2020年在巴西巴伊亚州萨尔瓦多进行的一项随机双盲临床试验。诊断为COVID-19的成年患者随机接受标准高蛋白等热量补充剂(对照组)或富含免疫营养素的补充剂(实验),为期07天。对参与者进行为期08天的监测,包括评估风险和营养状况,收集血液样本以评估白蛋白、IL-6和TNF-α。结果:70例患者纳入研究。64只随机分为免疫营养饮食组和标准对照饮食组。营养诊断为27.6(±0.8)kg/m²,营养风险为41.9%。实验组白蛋白平均升高0.84(±0.65)mg/dL,对照组平均升高0.21(±0.52)mg/dL。在IL-6剂量方面,实验组(-257.27±448.89 pg/ml)和对照组(-142.75±253.29 pg/ml)均有所降低。比较TNF-α水平的差异,实验组降低(-3.72±5.98 pg/ml),对照组升高(5.33±10.48 pg/ml)。结论:使用富含免疫营养素的口服补充剂似乎能够降低血清IL-6和TNF-α水平,并增加血清白蛋白水平。
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引用次数: 0
Analysis of TyG index and TG/HDL ratio with hyperuricemia in patients with H-type hypertension. h型高血压高尿酸血症患者TyG指数及TG/HDL比值分析。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-02-27 DOI: 10.20960/nh.05630
Ziqiang Luo, Jie Yang, Changyi Wang, Chaoying Luo, Hongen Chen, Chunfang Lv, Linzhen Qin, Lanlan Wu, Mei Luo, Zhigang Huang, Tao Zhang

Introduction: Background: the concurrent occurrence of hyperuricemia and hypertension is a significant public health issue, highlighting the need for effective predictive markers. Objective: this study aimed to assess the correlation between hyperuricemia and two metabolic indices, the TyG index and the TG/HDL ratio, in H-type hypertension patients, with gender-specific analysis. Material and methods: a cohort of 7,051 patients was selected from a stroke risk screening program in Nanshan District between 2017-2018 and 2021-2023. Logistic regression and restricted cubic spline modeling were used to evaluate the risk and dose-response relationships. Results: the highest quartiles of both indices were associated with an increased risk of hyperuricemia, with stronger predictive power in females. Nonlinear and linear dose-response relationships were observed between the TyG index and hyperuricemia in males and females, respectively, while the TG/HDL ratio showed a nonlinear association with hyperuricemia in both genders. No association was found between these indices and homocysteine levels. Conclusion: these results suggest that the TyG index and TG/HDL ratio could serve as predictive biomarkers for hyperuricemia in H-type hypertension, particularly in females.

背景:高尿酸血症和高血压的同时发生是一个重大的公共卫生问题,强调需要有效的预测标志物。目的:本研究旨在评估h型高血压患者高尿酸血症与TyG指数和TG/HDL比值两项代谢指标的相关性,并进行性别分析。材料和方法:从南山区2017-2018年至2021-2023年卒中风险筛查项目中选取7051例患者。采用Logistic回归和限制三次样条模型来评估风险和剂量-反应关系。结果:两个指数的最高四分位数与高尿酸血症的风险增加有关,在女性中具有更强的预测能力。在男性和女性中,TyG指数与高尿酸血症分别呈非线性和线性剂量反应关系,而TG/HDL比值与高尿酸血症在两性中均呈非线性关系。这些指标与同型半胱氨酸水平无相关性。结论:这些结果表明TyG指数和TG/HDL比值可以作为h型高血压患者高尿酸血症的预测性生物标志物,特别是在女性中。
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引用次数: 0
Real-world study of 24 weeks to assess the effect of a partial meal replacement program on metabolic syndrome and its components in adult patients with obesity. 为期24周的真实世界研究,以评估部分膳食替代方案对成年肥胖患者代谢综合征及其组成部分的影响。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-02-27 DOI: 10.20960/nh.05716
Daniel de Luis, Olatz Izaola, David Primo, Juan José López Gomez

Introduction: Background: meal replacement (MR) diets consist of replacing one or more meals. The objective was to evaluate the effect of a MR diet on weight reduction and metabolic syndrome (MS). Methods: a real-world study was designed with a MR diet. The first phase consisted of the replacement of one meal (12 weeks); and the second phase the reintroduction of foods following a low-calorie diet (-300 to -500 calories per day) (12 weeks). Anthropometric and biochemical measurements were performed at initiation of the study; 12 and 24 weeks. Results: the mean age was 45.6 ± 3.5 years (n = 364). There were 100 males (27.5 %) and 264 females (72.5 %) enrolled. We observed significant improvements at 12 weeks and 24 weeks in body weight, BMI, fat mass, waist circumference, serum triglycerides, LDL cholesterol, glucose, insulin, HOMA-IR, and frequencies of (MS, central obesity, hypertriglyceridemia, hypertension, and hyperglycaemia). The odds ratio of MS after phase 2 (24 weeks) was 0.66 (95 % CI = 0.49-0.90; p = 0.03). The number needed to treat was 10.17 patients for the resolution of one MS (95 % CI 6.15-41.2; p = 0.02). Conclusions: in patients with obesity, those MR diet decreased in weight and fat mass with a secondary improvement in metabolic parameters.

背景:膳食替代(MR)饮食包括替代一餐或多餐。目的是评估MR饮食对减肥和代谢综合征(MS)的影响。方法:采用磁共振饮食法设计了一项真实世界的研究。第一阶段为替换一餐(12周);第二阶段是在低热量饮食(每天-300到-500卡路里)之后重新引入食物(12周)。在研究开始时进行人体测量和生化测量;12周和24周。结果:平均年龄45.6±3.5岁(n = 364)。男性100人(27.5%),女性264人(72.5%)。在12周和24周时,我们观察到体重、BMI、脂肪量、腰围、血清甘油三酯、低密度脂蛋白胆固醇、葡萄糖、胰岛素、HOMA-IR和(多发性硬化症、中枢性肥胖、高甘油三酯血症、高血压和高血糖)频率的显著改善。2期(24周)后MS的优势比为0.66 (95% CI = 0.49-0.90;P = 0.03)。需要治疗的人数为10.17例患者才能解决1例多发性硬化(95% CI 6.15-41.2;P = 0.02)。结论:在肥胖患者中,MR饮食降低了体重和脂肪量,并改善了代谢参数。
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引用次数: 0
Dietary habits and body composition in amateur rhythmic gymnastics. 业余艺术体操运动员的饮食习惯与身体组成。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-02-27 DOI: 10.20960/nh.05963
Daniel González-Devesa, Eva González-Devesa, Josué Prieto-Prieto, Belén Portas-Núñez, Carlos Ayán-Pérez, Patricia Regal López

Introduction: Introduction: rhythmic gymnastics is a highly demanding aesthetic sport that has been associated with an increased risk of eating disorders, body dissatisfaction and nutritional deficits. Objectives: providing data on the dietary habits and body composition of Spanish amateur rhythmic gymnasts. Methods: descriptive transversal study on 56 female amateur rhythmic gymnasts practicing within clubs belonging to the Galician Gymnastics Federation, categorized into pre-teens (10-12 yrs) and teens (13-18 yrs). Anthropometric measurements were performed following ISAK protocols and complemented with bioimpedance. Dietary intake was qualitative and quantitatively determined through a three-day food record and a food frequency questionnaire. Physical activity level was estimated by an activity and training record. The Eating Attitudes Test (EAT-40) was used to identify disordered eating attitudes. Results: anthropometric data showed significantly lower z-scores, body fat percentage, triceps skinfold thickness, and waist-to-hip ratio in pre-teen gymnasts than in teens, and higher body water and mineral mass percentages. Pre-teens accumulated higher training load. Energy intake was lower than estimated energy expenditure and Spanish recommendations. The intake of fiber, legumes, fruit, vegetables, oils and fats did not reach the recommendations, while sugar and protein exceeded them. EAT-40 reflected no signs of eating disorders, with older gymnasts showing higher scores. Conclusions: suboptimal intake of energy and certain food groups such as legumes, vegetables, fruit and healthy fats, plus high training loads, could negatively impact health and performance of young female athletes. Considering the high nutritional and physical demands of rhythmic gymnastics, attention should be addressed to their diet and eating behaviors.

艺术体操是一项对审美要求很高的运动,与饮食失调、身体不满和营养缺乏的风险增加有关。目的:提供西班牙业余艺术体操运动员的饮食习惯和身体组成数据。方法:对56名在加利西亚体操联合会所属俱乐部练习的业余艺术体操女运动员进行描述性横向研究,分为青春期前(10-12岁)和青少年(13-18岁)。按照ISAK方案进行人体测量,并辅以生物阻抗。通过三天的食物记录和食物频率问卷,定性和定量地确定饮食摄入量。通过活动和训练记录来评估身体活动水平。饮食态度测试(EAT-40)用于识别饮食失调的态度。结果:人体测量数据显示,青少年前体操运动员的z分数、体脂率、三头肌皮褶厚度和腰臀比明显低于青少年,身体水分和矿物质质量百分比较高。青少年前期积累了更高的训练负荷。能量摄入低于估计的能量消耗和西班牙的建议。纤维、豆类、水果、蔬菜、油和脂肪的摄入量没有达到建议值,而糖和蛋白质的摄入量则超过了建议值。EAT-40没有反映饮食失调的迹象,年龄越大的体操运动员得分越高。结论:能量和某些食物(如豆类、蔬菜、水果和健康脂肪)的次优摄入,加上高训练负荷,可能对年轻女运动员的健康和表现产生负面影响。考虑到艺术体操对营养和体能的高要求,应注意其饮食和饮食行为。
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引用次数: 0
Evaluation of the relationship of carbohydrate quality with sleep quality and depression in type 2 diabetes patients. 2型糖尿病患者碳水化合物质量与睡眠质量及抑郁关系的评价。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-02-27 DOI: 10.20960/nh.05597
Emine Elibol, Zehra Çelik, Havva Dereli

Introduction: Background: diabetes mellitus is increasing globally. The macronutrient content of food consumed by diabetic patients plays a critical role in the course of the disease. Objective: this study aimed to evaluate the effect of carbohydrate quality on sleep quality and depression in patients with type 2 diabetes. Method: a total of 150 individuals with type 2 diabetes were included in the study. A demographic questionnaire, sleep quality scale (SQS) (where higher scores indicate poorer sleep quality), and the depression, anxiety, and stress scale (DASS) were administered to participants. Additionally, a food frequency questionnaire consisting of 132 foods was used. To determine the Carbohydrate Quality Index (CQI) score, four components (fiber intake, whole grain ratio, glycemic index, and total carbohydrate ratio) were assessed on a scale of 1-5 points. The total CQI score was calculated, with Q5 representing the highest carbohydrate quality and Q1 the lowest. Data were analyzed using the SPSS 24 program. Results: the mean age of participants was 53.9 ± 16.38 years. The mean CQI score was 15.5 ± 2.57 in men and 13.2 ± 3.02 in women. Anxiety and depression levels were higher in women than in men. The highest SQS scores were observed in the Q1 group, indicating poorer sleep quality. Anxiety and depression scores were highest in the Q5 group and lowest in the Q1 group (p < 0.05). A positive correlation was found between CQI scores and sub-scores of depression, anxiety, and stress, while a negative correlation was observed with SQS scores. Conclusion: the study found that as carbohydrate quality was associated with worsened sleep quality, and higher levels of anxiety, stress, and depression, although the relationship was weak. Further research on this topic is needed.

背景:糖尿病在全球范围内呈上升趋势。糖尿病患者所摄入的食物中常量营养素的含量在其病程中起着至关重要的作用。目的:探讨碳水化合物质量对2型糖尿病患者睡眠质量和抑郁的影响。方法:共纳入150例2型糖尿病患者。对参与者进行人口统计问卷、睡眠质量量表(SQS)(分数越高表明睡眠质量越差)和抑郁、焦虑和压力量表(DASS)。此外,还使用了一份包含132种食物的食物频率问卷。为了确定碳水化合物质量指数(CQI)评分,在1-5分的范围内评估四个组成部分(纤维摄入量、全谷物比、血糖指数和总碳水化合物比)。计算总CQI评分,其中Q5代表最高的碳水化合物品质,Q1代表最低的碳水化合物品质。数据采用SPSS 24软件进行分析。结果:参与者平均年龄为53.9±16.38岁。平均CQI评分男性为15.5±2.57,女性为13.2±3.02。女性的焦虑和抑郁水平高于男性。Q1组的SQS得分最高,表明睡眠质量较差。焦虑、抑郁评分以Q5组最高,Q1组最低(p < 0.05)。CQI评分与抑郁、焦虑、压力分呈正相关,与SQS评分呈负相关。结论:研究发现,碳水化合物的质量与睡眠质量恶化、焦虑、压力和抑郁程度升高有关,尽管这种关系很弱。这一课题需要进一步的研究。
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引用次数: 0
Effects of concurrent training in metabolic syndrome markers of morbidly obesity patients according muscle quality index and age. 同时训练对病态肥胖患者代谢综合征指标(肌肉质量指数和年龄)的影响。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-02-27 DOI: 10.20960/nh.05915
Felipe Caamaño-Navarrete, Cristian Gabriel Álvarez, Indya Del-Cuerpo, Claudio Hernández-Mosqueira, Guido Contreras-Díaz, Pedro Delgado-Floody

Introduction: Objective: this study aimed to determine the effects of a concurrent training program on metabolic syndrome (MetS) markers, body mass, body fat, and fitness in patients with severe or morbid obesity, comparing two Muscle Quality Index (MQI)groups (High-MQI vs. Low-MQI) across different age categories (young adults [Y-ad, 18-29.9 years], middle-aged adults [MA-ad, 30-49.9 years], and intermediate adults [I-ad, 50-59.9 years]). Methods: twenty-seven patients with severe or morbid obesity (Low-MQI n = 15, High-MQI n = 12) participated in a 16-week exercise program. MetS markers, body composition, and fitness parameters were evaluated before and after the intervention. Results: low-MQI Group: middle-aged adults showed significant reductions in weight (107.5 ± 10.6 to 108.8 ± 12.9 kg, p = 0.029) and BMI (43.8 ± 3.4 to 42.4 ± 4.2 kg/m2, p = 0.0006). In intermediate adults (I-ad), there was a notable increase in diastolic blood pressure (78 ± 9 to 87 ± 5 mmHg, p = 0.012). High-MQI Group: young adults exhibited significant decreases in waist circumference (122.6 ± 11.4 to 115.9 ± 11.9 cm, p = 0.012) and BMI (43.8 ± 3.4 to 42.4 ± 4.2 kg/m2, p = 0.0006). Among middle-aged adults, systolic blood pressure declined significantly (139 ± 15.2 to 126 ± 8.3 mmHg, p = 0.025) and diastolic blood pressure improved (90 ± 4 to 82 ± 3 mmHg, p = 0.044). Conclusion: a 16-week concurrent training program led to positive changes in weight, BMI, and select MetS indicators among individuals with severe or morbid obesity.

目的:本研究旨在确定同步训练计划对严重或病态肥胖患者代谢综合征(MetS)标志物、体重、体脂和健康的影响,比较不同年龄组(青壮年[Y-ad, 18-29.9岁]、中年人[MA-ad, 30-49.9岁]和中等成年人[I-ad, 50-59.9岁])的两个肌肉质量指数(MQI)组(高MQI vs低MQI)。方法:27例重度或病态肥胖患者(mqi低15例,mqi高12例)参加为期16周的运动计划。在干预前后评估met标记物、身体成分和健康参数。结果:低mqi组中年人体重(107.5±10.6 ~ 108.8±12.9 kg, p = 0.029)、BMI(43.8±3.4 ~ 42.4±4.2 kg/m2, p = 0.0006)显著降低。中度成人(I-ad)舒张压显著升高(78±9至87±5 mmHg, p = 0.012)。高mqi组:青壮年腰围(122.6±11.4 ~ 115.9±11.9 cm, p = 0.012)、BMI(43.8±3.4 ~ 42.4±4.2 kg/m2, p = 0.0006)显著降低。中年人的收缩压明显下降(139±15.2 ~ 126±8.3 mmHg, p = 0.025),舒张压明显改善(90±4 ~ 82±3 mmHg, p = 0.044)。结论:在重度或病态肥胖患者中,16周的同步训练计划导致体重、BMI和某些MetS指标的积极变化。
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引用次数: 0
Metabolic characteristics of aortic aneurysm: a two-sample Mendelian randomization study. 主动脉瘤的代谢特征:一项双样本孟德尔随机化研究。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-02-27 DOI: 10.20960/nh.05798
Quao-Zhi Wang, Yong-Mei Sun, Yu-Quan Tian

Introduction: Introduction: alterations in plasma metabolites are increasingly recognized as an important characteristic of aortic aneurysms (AA). Objective: to evaluate the causal effects of circulating metabolites and their metabolic pathways on the risk of developing AA using a two-sample Mendelian randomization (MR) method. Methods: metabolite data were derived from the Canadian Longitudinal Study on Aging, and the genome-wide association study (GWAS) summary data on AA were obtained from the FinnGen Consortium. Instrumental variables were rigorously selected, and a range of MR analysis methods were employed to identify metabolites associated with AA, followed by metabolic pathway enrichment analysis of these metabolites. Results: among the 1,400 metabolites analyzed, 77 were found to demonstrate a causal relationship to AA. Notably, 13-hydroxyoctadecadienoic acid (13-HODE) + 9-hydroxyoctadecadienoic acid (9-HODE) (OR = 0.835, p = 0.001) and linoleoylcholine (OR = 0.867, p = 0.012) were negatively associated with AA risk, while C24 ceramide (d18:1/24:0) (OR = 1.167, p = 0.002) and kynurenine (OR = 1.096, p = 0.021) were positively associated. The synthesis pathways for valine, leucine, and isoleucine were positively correlated with AA, whereas the caffeine metabolic pathway showed a negative correlation. Conclusion: personalized nutrition management combined with metabolite level monitoring may contribute to reducing the risk of AA and improve long-term health outcomes in affected individuals.

简介:血浆代谢物的改变越来越被认为是主动脉瘤(AA)的一个重要特征。目的:采用双样本孟德尔随机化(MR)方法,评价循环代谢物及其代谢途径与AA发生风险的因果关系。方法:代谢物数据来源于加拿大老龄化纵向研究(Canadian Longitudinal Study on Aging), AA全基因组关联研究(GWAS)汇总数据来源于FinnGen Consortium。严格选择工具变量,采用一系列MR分析方法鉴定与AA相关的代谢物,然后对这些代谢物进行代谢途径富集分析。结果:在分析的1400种代谢物中,发现77种与AA有因果关系。13-羟基十八烯二烯酸(13-HODE) + 9-羟基十八烯二烯酸(9-HODE) (OR = 0.835, p = 0.001)和亚油胆碱(OR = 0.867, p = 0.012)与AA风险呈负相关,C24神经酰胺(d18:1/24:0) (OR = 1.167, p = 0.002)和犬尿氨酸(OR = 1.096, p = 0.021)与AA风险呈正相关。缬氨酸、亮氨酸和异亮氨酸的合成途径与AA呈正相关,而咖啡因的代谢途径与AA呈负相关。结论:个性化营养管理结合代谢物水平监测可能有助于降低AA风险,改善受影响个体的长期健康结局。
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引用次数: 0
The impact of low-dose enteral nutrition administered at varying rates on gastric emptying in patients with large hemispheric infarction undergoing therapeutic hypothermia: a retrospective analysis. 低剂量肠内营养对大半球梗死患者治疗性低温胃排空的影响:回顾性分析。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-02-27 DOI: 10.20960/nh.05849
Miao Li, Wenya Cao, Linlin Fan, Fei Tian

Introduction: Purpose: understanding gastric emptying at different rates of low-dose enteral nutrition is crucial for managing enteral feeding during therapeutic hypothermia (TH). Methods: this study retrospectively reviewed the records of 42 patients who received TH at a single neurological intensive care unit. Patients received either 10 ml/h or 30 ml/h feeding. The gastric residual volumes (GRVs) were collected daily for 7 days during TH. In addition, demographic characteristics and disease severity (APACHE-II score) were also collected. Results: GRVs in the 30 ml/h group were significantly higher than in the 10 ml/h group (p < 0.05). Both groups showed an initial increase in GRVs, peaking on day 2 (39.99 ± 17.73 ml vs 102.74 ± 43.19 ml, p = 0.000), followed by a gradual decrease. There was no significant difference in vomiting (4.0 % vs 11.8 %, p = 0.079) or ventilator associated pneumonia (VAP) incidence (8.0 % vs 17.6 %, p = 0.898) between the groups. Conclusions: patients with large hemispheric infarction may likely tolerate an initial feeding rate of 30 ml/h during TH. Feeding rates should be gradually increased from day 3 based on patient condition.

目的:了解不同低剂量肠内营养率下的胃排空对治疗性低温(TH)期间肠内喂养的管理至关重要。方法:本研究回顾性回顾了42例在同一神经重症监护病房接受TH治疗的患者的记录。患者接受10 ml/h或30 ml/h的喂养。在TH期间,每天收集胃残量(GRVs),持续7 d。此外,还收集了人口统计学特征和疾病严重程度(APACHE-II评分)。结果:30 ml/h组GRVs显著高于10 ml/h组(p < 0.05)。两组grv均出现初始升高,在第2天达到峰值(39.99±17.73 ml vs 102.74±43.19 ml, p = 0.000),随后逐渐下降。两组间呕吐(4.0% vs 11.8%, p = 0.079)和呼吸机相关性肺炎(VAP)发生率(8.0% vs 17.6%, p = 0.898)无显著差异。结论:大半球梗死患者在TH期间可能耐受30 ml/h的初始喂养速率。从第3天开始,应根据患者情况逐渐增加喂养率。
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Nutricion hospitalaria
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