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Predictive value of novel inflammatory markers for mortality in patients with chronic kidney disease ‒ Evidence from NHANES 1999-2018. 新型炎症标志物对慢性肾病患者死亡率的预测价值——来自NHANES 1999-2018的证据
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-01-09 DOI: 10.20960/nh.05709
Xiaoping Chen, Weiqing Hu, Jing Ji

Introduction: Introduction: this study evaluated the predictive value of inflammatory indices including neutrophil-percentage-to-albumin ratio (NPAR), systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and eosinophil-to-lymphocyte ratio (ELR) for mortality in adults with chronic kidney disease (CKD). Methods: this study analyzed adults aged 40-79 years with CKD from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. Cox regression models assessed associations between inflammatory indices and all-cause/cardiovascular disease (CVD) mortality. Receiver operating characteristic curves evaluated their predictive accuracy. Restricted cubic splines and recursive algorithm analyzed threshold effects. Subgroup analyses were performed by demographic and clinical characteristics. Results: among 2496 subjects, elevated NPAR (HR: 2.05, 95 % CI: 1.62-2.59), NLR (HR: 2.28, 95 % CI: 1.78-2.93), ELR (HR: 1.61, 95 % CI: 1.27-2.03) and SII (HR: 1.61, 95 % CI: 1.26-2.06) were independently associated with increased all-cause mortality risk after adjustment. Similar patterns were observed for CVD mortality. NPAR showed the highest predictive value for both all-cause mortality (AUC: 0.610) and CVD mortality (AUC: 0.599). Non-linear relationships and threshold effects were identified between NPAR and mortality. The associations remained consistent across subgroups, with NPAR showing enhanced prediction in diabetic patients (p for interaction = 0.029). Conclusion: NPAR, SII, and NLR independently predicted mortality in CKD patients. NPAR demonstrated the strongest predictive capability, particularly in patients with diabetes, suggesting its potential as a practical tool for mortality risk stratification in CKD.

简介:本研究评估了包括中性粒细胞百分比-白蛋白比(NPAR)、全身免疫-炎症指数(SII)、中性粒细胞-淋巴细胞比(NLR)和嗜酸性粒细胞-淋巴细胞比(ELR)在内的炎症指标对成人慢性肾病(CKD)患者死亡率的预测价值。方法:本研究分析了1999-2018年国家健康与营养检查调查(NHANES)中40-79岁的CKD患者。Cox回归模型评估了炎症指数与全因/心血管疾病(CVD)死亡率之间的关系。受试者工作特性曲线评估其预测精度。限制三次样条和递归算法分析了阈值效应。根据人口学和临床特征进行亚组分析。结果:在2496名受试者中,调整后NPAR(风险比:2.05,95% CI: 1.62-2.59)、NLR(风险比:2.28,95% CI: 1.78-2.93)、ELR(风险比:1.61,95% CI: 1.27-2.03)和SII(风险比:1.61,95% CI: 1.26-2.06)升高与全因死亡风险增加独立相关。心血管疾病死亡率也观察到类似的模式。NPAR对全因死亡率(AUC: 0.610)和心血管疾病死亡率(AUC: 0.599)的预测值均最高。NPAR与死亡率之间存在非线性关系和阈值效应。各亚组的相关性保持一致,NPAR对糖尿病患者的预测增强(相互作用p = 0.029)。结论:NPAR、SII和NLR独立预测CKD患者的死亡率。NPAR显示出最强的预测能力,特别是在糖尿病患者中,这表明它有潜力作为CKD死亡风险分层的实用工具。
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引用次数: 0
Hand-grip strength in adults aged 18 to 59 years: association with exercise level, anthropometrics, and body composition. 18至59岁成人的握力:与运动水平、人体测量学和身体组成的关系
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-01-09 DOI: 10.20960/nh.05688
Vianney Curiel-Cervantes, Luis Ramírez-Olvera, Marie Bedos, Raúl Paredes Guerrero

Introduction: Background: exercise impacts hand-grip strength (HGS) performance in adults. There is controversy regarding anthropometric and body composition indicators associated with HGS. We analyzed the association between HGS, anthropometry, and body composition parameters according to exercise level. Methods: we evaluated 209 participants, 104 men and 105 women between 18 and 59 y/o. Subjects were categorized according to the Global Physical Activity Questionnaire and the American Physical Activity Guidelines into two groups: Non-Adequate Level of Exercise (NALE) and Adequate Level of Exercise (ALE). Physical activity level was determined using the FAO/WHO factorial method. Body composition was performed using electrical bioimpedance. HGS was measured with a digital dynamometer (BTE™). Results: age did not correlate with HGS. Men and women in the ALE group had a lower level of fat mass index (p < 0.05) and higher levels of skeletal muscle index (SMI) (p < 0.05) and HGS (p = 0.008). Men in the normal SMI and overweight body mass index groups exhibited higher handgrip strength (HGS). In both sexes, the taller group had higher HGS values (p = 0.03). Significant correlations were observed in men between HGS and height, exercise, fat-free mass, and SMI. In women, there were significant correlations between fat mass and height. In no case was the effect size strong. HGS estimation models by sex are presented. Conclusion: height, exercise, and muscle mass influenced hand-grip strength in men, while height and adiposity did so in women.

背景:运动影响成人握力(HGS)的表现。关于与HGS相关的人体测量和身体成分指标存在争议。我们根据运动水平分析了HGS、人体测量和身体成分参数之间的关系。方法:我们评估了209名参与者,其中104名男性和105名女性,年龄在18岁至59岁之间。受试者根据全球体育活动问卷和美国体育活动指南分为两组:运动水平不足(NALE)和运动水平充足(ALE)。采用FAO/WHO析因法确定身体活动水平。采用电生物阻抗法测定体成分。HGS采用数字测功机(BTE™)测量。结果:年龄与HGS无关。ALE组男性和女性的脂肪质量指数较低(p < 0.05),骨骼肌指数(SMI)和HGS水平较高(p = 0.008)。正常重度认知程度组和超重体重指数组的男性表现出更高的握力(HGS)。在两性中,身高组的HGS值较高(p = 0.03)。在男性中,HGS与身高、运动、无脂质量和重度精神分裂症之间存在显著相关性。在女性中,脂肪量和身高之间存在显著的相关性。在任何情况下,效应量都不强。提出了按性别划分的HGS估计模型。结论:身高、运动和肌肉质量影响男性的握力,而身高和肥胖影响女性的握力。
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引用次数: 0
Clinical factors associated with non-compliance with indicators of prescribed and infused volume of enteral nutrition therapy. 肠内营养治疗处方及输注量指标不符合的临床因素。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-01-09 DOI: 10.20960/nh.05493
Bruna Stamm, Mariur Gomes Beghetto, Michelli Cristina Silva de Assis, Cláudia Satiko Takemura Matsuba

Introduction: Objective: to evaluate the factors associated with non-compliance with the Quality Indicators in Nutritional Therapy (QINT) related to the prescribed and infused volume of Enteral Nutritional Therapy (ENT). Method: cross-sectional study, aligned with a prospective cohort, carried out in two clinical wards and two surgical wards of a Brazilian public hospital of high complexity and reference in ENT. Patients aged > 18 years, of both sexes, who required ENT exclusively by tube were included. The QINT "enteral volume infused index" and "frequency of days of adequate administration of the prescribed volume X volume infused in patients on ENT" were analyzed. Multivariate Poisson regression was adopted to identify factors associated with the outcome. Results: the 159 patients included totaled 565 days using ENT. The independent risk factors for non-compliance with the "enteral volume infused index" indicator were: being a surgical patient (HR: 2.12; 95 % CI: 1.31-3.41; p = 0.002), the presence of chronic obstructive pulmonary disease (COPD) (HR: 2.34; 95 % CI: 1.54-3.57; p = 0.002) and use of antidiarrheals (HR: 2.35; 95 % CI: 1.45-3.80; p = 0.001). The use of antidiarrheals (HR 19.75; 95 % CI: 10.05-38.79; p = 0.000) was the only risk factor identified for non-compliance with the indicator "frequency of days of adequate administration of the prescribed volume X volume infused in patients on ENT." Conclusions: surgical patients, those with COPD, and those using antidiarrheals are at greater risk of not reaching the prescribed ENT volume over the prescribed days.

目的:评价肠内营养治疗(ENT)处方量和输注量相关的营养治疗质量指标(QINT)不符合的相关因素。方法:横断面研究,与前瞻性队列对齐,在巴西公立医院的两个临床病房和两个外科病房进行的高度复杂和参考耳鼻喉科。患者年龄在bb0 - 18岁,男女,谁需要完全通过管耳鼻喉科纳入。分析QINT“肠内灌注量指数”和“ENT患者充分给予规定容量X灌注量的天数频率”。采用多元泊松回归来确定与结果相关的因素。结果:纳入159例患者,共使用565天。不遵守“肠内灌注量指数”指标的独立危险因素为:手术患者(HR: 2.12; 95% CI: 1.31-3.41; p = 0.002)、存在慢性阻塞性肺疾病(COPD) (HR: 2.34; 95% CI: 1.54-3.57; p = 0.002)和使用止泻药(HR: 2.35; 95% CI: 1.45-3.80; p = 0.001)。止泻药的使用(HR 19.75; 95% CI: 10.05-38.79; p = 0.000)是唯一不符合指标“ENT患者给予足够剂量X量输液的天数频率”的危险因素。结论:手术患者、COPD患者和使用止泻药的患者在规定天数内未达到规定的耳鼻喉容积的风险更大。
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引用次数: 0
Perception of the Chilean adult population on the factors influencing the adoption of a sustainable diet. 智利成年人口对影响采用可持续饮食的因素的看法。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-01-09 DOI: 10.20960/nh.06059
Ximena Rodríguez Palleres, Mario Castillo-Ruiz, Sebastián A Correa, Fancy Rojas González, Javier Carmona Grez, Álvaro Toledo San Martín

Introduction: Introduction: in the context of the climate crisis and growing concern for sustainable food systems, understanding public perceptions is key to informing public policies and intervention strategies. Objective: to explore the knowledge and perceptions of Chilean adults regarding the environmental, cultural, and nutritional factors that influence the adoption of sustainable dietary practices. Methods: a cross-sectional study that analyzed the perceptions of 470 Chilean adults on environmental, cultural, and nutritional factors related to sustainable eating. A survey was carried out between January and August 2024, assessing 12 dimensions associated with food sustainability. Results: younger participants (18-30 years), women, and individuals with higher educational levels placed greater importance on aspects such as low environmental impact, respect for biodiversity, and the consumption of organic products. Statistically significant differences were observed by age group, educational level, and sex, revealing sociocultural patterns associated with interest in and knowledge of sustainable food practices. Conclusion: these findings highlight the need for targeted public policies, inclusive educational strategies, and actions that promote sustainable dietary habits across diverse population sectors.

导言:在气候危机和对可持续粮食系统日益关注的背景下,了解公众的看法是为公共政策和干预战略提供信息的关键。目的:探讨智利成年人对影响可持续饮食习惯的环境、文化和营养因素的认识和看法。方法:一项横断面研究,分析了470名智利成年人对与可持续饮食有关的环境、文化和营养因素的看法。2024年1月至8月期间进行了一项调查,评估了与食品可持续性相关的12个维度。结果:年轻的参与者(18-30岁)、女性和受教育程度较高的个人更重视低环境影响、尊重生物多样性和消费有机产品等方面。在统计上,不同年龄组、教育水平和性别之间存在显著差异,揭示了与可持续食品实践的兴趣和知识相关的社会文化模式。结论:这些发现突出表明,需要制定有针对性的公共政策、包容性教育战略和行动,促进不同人口群体的可持续饮食习惯。
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引用次数: 0
Incorporating population-specific genetic markers into early detection panels for NAFLD - A complement to biomarker approaches. 将人群特异性遗传标记纳入NAFLD的早期检测面板-生物标记方法的补充。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-01-09 DOI: 10.20960/nh.05962
Sergio Vladimir Flores-Carrasco, Ángel Roco-Videla, Román Montaña-Ramírez

Introduction:

作品简介:
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引用次数: 0
Renal Inpatient Nutrition Screening Tool (Renal iNUT) - A validity and reliability assesment for Turkey. 肾住院病人营养筛选工具(肾iNUT) -有效性和可靠性评估的土耳其。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-01-09 DOI: 10.20960/nh.05697
Ayfer Beyaz Coşkun, Emine Elibol, Fatih Genç, Esin Erdoğan

Introduction: Background and aims: there is a need for a kidney-specific nutritional screening tool for patients with renal failure. It was planned to perform the validity and reliability of the Renal Inpatient Nutrition Screening Tool screening tool developed for renal patients in Turkey. Methods: the validity and reliability of the Renal Inpatient Nutrition Screening Tool were investigated by comparing it with the Malnutrition Universal Screening Tool and the Subjective Global Assessment for assessing malnutrition in 153 adult patients newly admitted to the nephrology unit. Nutritional status was assessed using anthropometric measurements and nurse opinion was assessed using a questionnaire. Results: the Renal Inpatient Nutrition Screening Tool was found to be more sensitive than the Malnutrition Universal Screening Tool in identifying increased malnutrition risks and providing dietary guidance. Cramer V coefficient was 0.238 between the Malnutrition Universal Screening Tool and the Renal Inpatient Nutrition Screening Tool, and 0.137 between the Subjective Global Assessment and the Renal Inpatient Nutrition Screening Tool, indicating the compatibility of the Renal Inpatient Nutrition Screening Tool with the variables in the Malnutrition Universal Screening Tool screening tool. A significant positive moderate correlation was observed between the total number of red boxes in the Renal Inpatient Nutrition Screening Tool and the total score of Malnutrition Universal Screening Tool (p < 0.05; r = 0.404). Conclusions: the Renal Inpatient Nutrition Screening Tool is a valid and reliable tool for assessing malnutrition risks in renal patients in Turkey, particularly when used by experienced specialist nurses in nephrology units.

背景和目的:肾衰竭患者需要一种肾特异性营养筛查工具。计划对土耳其为肾病患者开发的肾住院患者营养筛查工具的效度和信度进行评估。方法:对153例肾内科新入院成人患者营养不良情况进行评估,并与营养不良普遍筛查工具和主观整体评估进行比较,考察肾内科住院患者营养筛查工具的效度和信度。采用人体测量法评估营养状况,采用问卷调查法评估护士意见。结果:肾脏住院患者营养筛查工具比营养不良普遍筛查工具在识别增加的营养不良风险和提供饮食指导方面更敏感。营养不良普遍筛查工具与肾脏住院患者营养筛查工具的克莱默V系数为0.238,主观全局评估与肾脏住院患者营养筛查工具的克莱默V系数为0.137,表明肾脏住院患者营养筛查工具与营养不良普遍筛查工具筛查工具中变量的兼容性。肾住院患者营养筛查工具红框总数与营养不良普遍筛查工具总分呈显著正相关(p < 0.05;R = 0.404)。结论:肾脏住院患者营养筛查工具是评估土耳其肾脏患者营养不良风险的有效和可靠的工具,特别是当肾脏科经验丰富的专科护士使用时。
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引用次数: 0
Mediterranean diet adherence and cardiovascular risk: exploring the role of advanced glycation end-products via skin autofluorescence analysis. 地中海饮食依从性和心血管风险:通过皮肤自身荧光分析探索晚期糖基化终产物的作用
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-01-09 DOI: 10.20960/nh.05465
Burak Erim, Yasemin Ecem Temel Pekmez, Zeynep Kaçar, Erdi Ergene

Introduction: Introduction: advanced glycation end-products contribute to oxidative stress and inflammation, which are linked to chronic diseases like cardiovascular disease and type-2 diabetes. Objectives: the aim of this study is to explore the relationship between adherence to the Mediterranean diet and cardiovascular risk, focusing on the influence of advanced glycation end-products assessed through skin autofluorescence analysis. Methods: anthropometric measurements including waist circumference, hip circumference, height, and body weight were recorded for 200 healthy individuals. Body mass index, waist-to-hip ratio, and waist-to-height ratio were calculated based on these measurements. Levels of advanced glycation end-products were assessed using the AGE Reader, while adherence to the Mediterranean diet was evaluated using the Mediterranean Diet Adherence Scale. Results: a significant negative correlation was found between high adherence to the Mediterranean diet and levels of advanced glycation end-products (p < 0.05). Conversely, advanced glycation end-product levels showed significant positive correlations with age, body weight, body mass index, waist circumference, hip circumference, and waist-to-height ratio (p < 0.05). Conclusion: this study demonstrates that individuals who adhere closely to the Mediterranean diet exhibit lower levels of advanced glycation end-products, which are established risk factors for cardiovascular disease.

导读:晚期糖基化终产物会导致氧化应激和炎症,这与心血管疾病和2型糖尿病等慢性疾病有关。目的:本研究的目的是探讨坚持地中海饮食与心血管风险之间的关系,重点关注通过皮肤自身荧光分析评估的晚期糖基化终产物的影响。方法:对200名健康人进行腰围、臀围、身高、体重等人体测量。身体质量指数、腰臀比和腰高比是根据这些测量计算出来的。使用AGE Reader评估晚期糖基化终产物水平,使用地中海饮食依从性量表评估地中海饮食依从性。结果:高度坚持地中海饮食与晚期糖基化终产物水平呈显著负相关(p < 0.05)。相反,晚期糖基化终产物水平与年龄、体重、体重指数、腰围、臀围和腰高比呈显著正相关(p < 0.05)。结论:本研究表明,坚持地中海饮食的个体表现出较低水平的晚期糖基化终产物,这是心血管疾病的已知危险因素。
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引用次数: 0
Association of the Alternative Healthy Eating Index with osteoporosis and muscle mass among U.S. adults aged 50 years and older. 替代健康饮食指数与骨质疏松症和50岁及以上美国成年人肌肉质量的关联。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-01-09 DOI: 10.20960/nh.05989
Hongfei Liu, Xinghai Yue, Xiangran Cui, Wei Wei, Shixuan Wang

Introduction: Objective: this study aimed to explore the association between the Alternative Healthy Eating Index (AHEI) and both osteoporosis and muscle mass among U.S. adults aged 50 years and older, using data from the National Health and Nutrition Examination Survey (NHANES). Methods: data from 9,466 participants were analyzed to examine the association between AHEI and osteoporosis, defined as a bone mineral density (BMD) T-score ≤ -2.5. Another 2,233 participants were included to evaluate the association between AHEI and muscle mass, measured by appendicular lean mass index (ALMI). Weighted multivariable logistic and linear regression analyses, restricted cubic spline (RCS) models, and subgroup analyses were conducted to investigate the relationships of AHEI with both outcomes. Results: compared with the lowest AHEI tertile (Q1), the highest tertile (Q3) was significantly associated with both a lower prevalence of osteoporosis (OR  =  0.55, 95 % CI: 0.38-0.80; p  =  0.002) and a reduced ALMI (β = -0.18, 95 % CI: -0.34 to -0.01; p = 0.039). The RCS analysis observed no significant nonlinear association, and subgroup analyses showed consistency across different population groups. Conclusion: a higher AHEI is significantly associated with a lower prevalence of osteoporosis and a lower ALMI among middle-aged and older U.S. adults, underscoring the necessity of developing more precise and personalized dietary interventions aimed at delaying age-related decline in both skeletal and muscular systems.

目的:本研究旨在探讨替代健康饮食指数(AHEI)与美国50岁及以上成年人骨质疏松症和肌肉质量之间的关系,研究数据来自美国国家健康与营养调查(NHANES)。方法:对9466名参与者的数据进行分析,以检查AHEI与骨质疏松症之间的关系,骨质疏松症的定义是骨密度(BMD) t评分≤-2.5。另外2,233名参与者被纳入评估AHEI和肌肉质量之间的关系,通过阑尾瘦质量指数(ALMI)来测量。采用加权多变量logistic和线性回归分析、限制性三次样条(RCS)模型和亚组分析来探讨AHEI与两种结果的关系。结果:与最低AHEI分位数(Q1)相比,最高分位数(Q3)与骨质疏松症患病率降低(OR = 0.55,95% CI: 0.38-0.80; p = 0.002)和ALMI降低(β = -0.18, 95% CI: -0.34至-0.01;p = 0.039)显著相关。RCS分析未发现显著的非线性关联,亚组分析显示不同人群之间的一致性。结论:在美国中老年成年人中,较高的AHEI与较低的骨质疏松症患病率和较低的ALMI显著相关,强调了开发更精确和个性化的饮食干预的必要性,旨在延缓与年龄相关的骨骼和肌肉系统衰退。
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引用次数: 0
[Study on nutrition and physical activity in the child and youth population with type 1 diabetes in Galicia]. [加利西亚儿童和青少年1型糖尿病患者的营养和身体活动研究]。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-01-09 DOI: 10.20960/nh.05873
David Novo Pantín, Uxía Rodríguez Lavandeira, Laura Regueiro Folgueira, Henrique Xoán Rodríguez Pantín, Rubén Pérez Cabanas, Roberto Silva Piñeiro, Arantxa Costas Rodríguez

Introduction: Introduction: type 1 diabetes (T1D) is a chronic disease whose proper nutritional and physical management can help prevent and manage complications. Objective: to assess the knowledge, influence, and behavior regarding eating habits and physical activity in children and adolescents with T1D, in relation to international guidelines, in order to identify areas for improvement. Methods: an electronic questionnaire was administered to 177 individuals aged 3 to 20 years during September and October 2023. The survey collected information on knowledge, influences, and behaviors related to diet and physical activity. Results: a total of 43.0 % consume vegetables daily, while 6.0 % never do. About 48.3 % eat fruits two or more times per day. A 6.0 % do not know how to count carbohydrates, and 15.0 % do not do so for every meal. To treat hypoglycemia, 62.0 % use juice or soft drinks, and 10.0 % rely on whatever food is available. Over 75.0 % reported modifying their dietary habits after diagnosis. Regarding physical activity, 51.0 % maintained their previous activity levels, and 22.0 % increased them. Identified barriers included a lack of knowledge about T1D and how to exercise properly. Conclusion: the results highlight the need for educational interventions targeting patients, families, and healthcare professionals to promote adherence to nutritional and physical activity recommendations, thereby improving disease control and preventing complications.

1型糖尿病(T1D)是一种慢性疾病,适当的营养和身体管理有助于预防和控制并发症。目的:根据国际准则,评估患有T1D的儿童和青少年在饮食习惯和身体活动方面的知识、影响和行为,以确定需要改进的领域。方法:于2023年9月至10月对177名3 ~ 20岁的个体进行电子问卷调查。该调查收集了有关饮食和体育活动的知识、影响和行为的信息。结果:43.0%的人每天吃蔬菜,而6.0%的人从不吃蔬菜。大约48.3%的人每天吃两次或两次以上的水果。6.0%的人不知道如何计算碳水化合物,15.0%的人不知道每餐都这样做。为了治疗低血糖,62.0%的人使用果汁或软饮料,10.0%的人依靠任何可用的食物。超过75.0%的人报告在诊断后改变了饮食习惯。在体力活动方面,51.0%的人保持了原来的运动量,22.0%的人增加了运动量。确定的障碍包括缺乏关于T1D和如何正确锻炼的知识。结论:结果强调需要针对患者、家庭和医疗保健专业人员进行教育干预,以促进对营养和身体活动建议的遵守,从而改善疾病控制和预防并发症。
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引用次数: 0
[Descriptive study of drug consumption, polypharmacy, and nutritional risk in patients undergoing periodic hemodialysis]. [周期性血液透析患者用药、多种用药和营养风险的描述性研究]。
IF 1.1 4区 医学 Q3 BUSINESS Pub Date : 2026-01-09 DOI: 10.20960/nh.05974
Esmeralda Josa Martín, Guillermina Barril Cuadrado, Graciela Álvarez García, Mª Del Mar Ruperto López

Introduction: Background and objective: polypharmacy is prevalent among patients undergoing hemodialysis (HD). This study aimed to determine the prevalence of polypharmacy and to define drug consumption according to pharmacotherapeutic classification, as well as to assess its association with clinical and nutritional outcomes in HD patients. Patients and methods: a cross-sectional, retrospective study in 96 prevalent patients on HD over a two-year period. Sociodemographic, clinical, nutritional, and laboratory data, as well as drug consumption, were collected. Polypharmacy was defined as the use of ≥ 4 drugs/day. Protein-energy wasting syndrome (PEW) was assessed using the malnutrition-inflammation score (MIS ≥ 5), and comorbidity was evaluated with the Charlson Comorbidity Index (CCI). Results: the prevalence of polypharmacy was 60.4 % (n = 58). Patients with polypharmacy had a higher body mass index and transferrin saturation but lower serum creatinine and HDL-cholesterol levels compared to those with low drug consumption (p < 0.05). Additionally, patients with polypharmacy had higher PEW and CCI score (> 3 points). Overall, the most used medications were intravenous iron-sucrose (90.6 %), erythropoiesis-stimulating agents (65.6 %), antihypertensives (58.0 %), and vitamin D (43.7 %). PEW was present in 34.8 % of patients, with a higher prevalence in the polypharmacy group (21.7 %). Conclusions: polypharmacy is highly prevalent among older adults on HD and is associated with higher comorbidity and nutritional risk. These findings highlight the need for a comprehensive and interdisciplinary approach to optimize the rational use of medications and improve the management of pluripathological patients undergoing HD.

背景与目的:多种用药在血液透析(HD)患者中普遍存在。本研究旨在确定多种用药的流行程度,根据药物治疗分类定义药物消费,并评估其与HD患者临床和营养结局的关系。患者和方法:对96例HD患者进行了为期两年的横断面回顾性研究。收集了社会人口学、临床、营养和实验室数据以及药物消费数据。多用药定义为每天使用≥4种药物。采用营养不良-炎症评分(MIS≥5)评估蛋白质-能量消耗综合征(PEW),并用Charlson合并症指数(CCI)评估合并症。结果:58例患者中有60.4%的人使用多种药物。多药组患者的体质指数、转铁蛋白饱和度较高,血清肌酐和高密度脂蛋白胆固醇水平较低(p < 0.05)。此外,多药组患者的PEW和CCI评分较高(bb0.3分)。总的来说,使用最多的药物是静脉注射蔗糖铁(90.6%)、促红细胞生成素(65.6%)、抗高血压药(58.0%)和维生素D(43.7%)。34.8%的患者出现了皮尤,多药组的患病率更高(21.7%)。结论:多重用药在老年HD患者中非常普遍,并与较高的合并症和营养风险相关。这些发现强调需要一个综合和跨学科的方法来优化药物的合理使用,并改善多病理HD患者的管理。
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