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Phase angle as a prognostic factor in patients with cancer: a systematic review of the existing evidence via a meta-analysis. 相位角作为癌症患者的预后因素:通过荟萃分析对现有证据进行系统回顾。
IF 2.5 4区 医学 Q3 BUSINESS Pub Date : 2024-12-13 DOI: 10.20960/nh.05517
Qianran Kong, Lijuan Tian, Yihan Wang, Min Yu

Background: the phase angle (PA) is expressed via bioelectrical impedance and an indicator of cell membrane health, integrity, hydration, and nutritional status. The associations between PA and cancer survival are inconsistent and unclear. This study aimed to assess PA's role as a prognostic marker of cancer survival.

Methods: we searched PubMed and EMBASE to identify all relevant studies up to December 2023. A meta-analysis was performed to clarify PA's prognostic role for cancer patients.

Results: a total of 30 studies covering 6587 participants were included in this study. There was a significant prognostic role for PA in the context of cancer patients' survival (HR = 0.73; 95 % CI, 0.66-0.81, p < 0.0001, I2 = 0.0 %). Patients with low PA values were 27 % less likely to survive than patients with high values. Our subgroup analyses showed that geographical population (American: HR = 0.66, 95 % CI: 0.55-0.79, I2 = 0.0 %; European: HR = 0.63, 95 % CI: 0.47-0.84, I2 = 23.2 %; Asian: HR = 0.48, 95 % CI: 0.31-0.74), the type of cancer (head and neck, colorectal, lung, or pancreatic cancer), and type of therapy (palliative vs. non-palliative treatment) did not change the prognostic value.

Conclusions: the findings highlight the potential of PA to be a non-invasive, cost-effective prognostic tool in oncological care.

背景:相位角(PA)通过生物电阻抗表示,是细胞膜健康、完整性、水合和营养状况的指标。PA 与癌症存活率之间的关联并不一致,也不清楚。本研究旨在评估 PA 作为癌症生存预后指标的作用。方法:我们检索了 PubMed 和 EMBASE,以确定截至 2023 年 12 月的所有相关研究。结果:本研究共纳入了 30 项研究,涉及 6587 名参与者。PA对癌症患者的生存有明显的预后作用(HR = 0.73; 95 % CI, 0.66-0.81, p < 0.0001, I2 = 0.0 %)。PA值低的患者存活率比PA值高的患者低27%。我们的亚组分析表明,地域人群(美国人、加拿大人、澳大利亚人和新西兰人)的PA值越低,存活率越高:HR=0.66,95% CI:0.55-0.79,I2=0.0%;欧洲人:HR=0.63,95% CI:0.47-0.84,I2=23.2%;亚洲人:HR=0.48,95% CI:0.31-0.74)、癌症类型(头颈癌、结直肠癌、肺癌或胰腺癌)和治疗类型(姑息治疗与非姑息治疗)均无变化。结论:研究结果凸显了 PA 在肿瘤治疗中作为一种无创、经济有效的预后工具的潜力。
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引用次数: 0
[Intersectionality as a tool in the field of nutrition]. [交叉性作为营养领域的工具]。
IF 2.5 4区 医学 Q3 BUSINESS Pub Date : 2024-12-13 DOI: 10.20960/nh.05598
Ángel Roco-Videla, Eduardo Leiva-Pinto
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引用次数: 0
Reproducibility and transparency in systematic reviews. 系统评价的可重复性和透明度。
IF 2.5 4区 医学 Q3 BUSINESS Pub Date : 2024-12-13 DOI: 10.20960/nh.05590
Joaquín González Aroca
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引用次数: 0
NHANES data analysis of the cardiometabolic index in relation to lumbar spine bone mineral density. NHANES数据分析心脏代谢指数与腰椎骨矿物质密度的关系。
IF 2.5 4区 医学 Q3 BUSINESS Pub Date : 2024-12-13 DOI: 10.20960/nh.05548
Rui Zhu, Chao-Ren Deng, Shao-Ping Wu

Objective: to investigate the correlation between cardiometabolic index (CMI) and lumbar spine bone mineral density (LSBMD) in U.S. adults.

Methods: the study selected eligible participants from the National Health and Nutrition Examination Survey (NHANES) database from 2011 to 2018. After adjusting for age, gender, race/ethnicity, body mass index (BMI), liver function markers, kidney function markers, blood routine indicators, metabolic markers, and chronic disease status, a logistic regression model combined with a restricted cubic spline model, smooth curve fitting, and threshold effect analysis was used to examine the association between CMI and LSBMD. Subgroup analysis was performed to verify the robustness of the results.

Result: among the 3,885 participants, for each unit increase in CMI, LSBMD decreased by 0.011 g/cm². Additionally, a turning point was identified at CMI = 0.797. When CMI was below 0.797, LSBMD decreased as CMI increased, showing a strong negative correlation (β = -0.077, 95 % CI: -0.097 to -0.058, p < 0.001). However, beyond this threshold, the relationship between CMI and LSBMD was no longer significant. Subgroup analysis revealed that the negative correlation between CMI and BMD was consistent across most subgroups (such as gender, BMI, hypertension, and high cholesterol), but instability was observed in subgroups such as individuals aged 51-59, Mexican Americans, non-Hispanic Blacks, and those with diabetes.

Conclusion: there exists a non-linear inverse correlation with CMI and LSBMD, showing that CMI could be a potential contributing factor for decreased bone mineral density, with a more pronounced effect within a specific range.

目的:探讨美国成人心脏代谢指数(CMI)与腰椎骨密度(LSBMD)的相关性。方法:研究从2011年至2018年国家健康与营养检查调查(NHANES)数据库中选择符合条件的参与者。在调整了年龄、性别、种族/民族、体重指数(BMI)、肝功能指标、肾功能指标、血常规指标、代谢指标和慢性疾病状态等因素后,采用logistic回归模型结合受限三次样条模型、平滑曲线拟合和阈值效应分析来检验CMI与LSBMD之间的关系。进行亚组分析以验证结果的稳健性。结果:在3885名参与者中,CMI每增加一个单位,LSBMD降低0.011 g/cm²。此外,在CMI = 0.797处发现了一个转折点。当CMI < 0.797时,LSBMD随CMI的升高而降低,呈较强的负相关(β = -0.077, 95% CI: -0.097 ~ -0.058, p < 0.001)。然而,超过这个阈值,CMI和LSBMD之间的关系不再显著。亚组分析显示,CMI和BMD之间的负相关在大多数亚组(如性别、BMI、高血压和高胆固醇)中是一致的,但在51-59岁、墨西哥裔美国人、非西班牙裔黑人和糖尿病患者等亚组中观察到不稳定。结论:CMI与LSBMD呈非线性负相关,说明CMI可能是导致骨密度降低的潜在因素,且在一定范围内作用更为显著。
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引用次数: 0
[Nutrition practice in type 2 diabetes: construction, validity and reliability of a scale]. 2型糖尿病患者的营养实践:量表的编制、效度和信度。
IF 2.5 4区 医学 Q3 BUSINESS Pub Date : 2024-11-22 DOI: 10.20960/nh.05147
Marcela Bañuelos Fonseca, Lilia Susana Gallardo Vidal, Iris Pineda Mujica, Adriana Jheny Rodríguez Méndez, Prishila Danae Reyes Chávez, Quintero Valdez Quintero Valdez

.

Background: diabetes is a complex disease that requires multiple strategies for glycemic control. The most challenging part is acquiring healthy eating practices. What is needed is to keep patients well informed and involved with their disease; for this, standardized, reliable instruments are required that allow evaluating the dietary practices in this population.

Objective: to build and to validate a highly reliable evaluation scale of feeding habits in patients with diabetes type 2.

Methodology: a cross-sectional design for the construction and validation of an evaluation scale for feeding habits in diabetes 2 patients. There were listed 63 questions subjected to review and statistics analysis that reduced it into a 30 ítems scale that was applied to 495 diabetes 2 patients in a first level attention clinic. There were used exploratory factorial analysis, sphericity Bartlett test, KMO, total variance explained, Spearman's r-test and Cronbach's alpha.

Results: a final version was obtained containing 30 ítems distributed in 8 dimensions with 3 response options on the Likert scale, with a Cronbach's alpha of 0.811. The exploratory factor analysis showed factor loads > 0.30. The total explained variance threw eight principal components; the KMO test = 0.833, Bartlett's test of sphericity, p = 0.000.

Conclusion: the scale to evaluate eating practices in patients with type 2 diabetes has the validity and high reliability to be able to apply it to this population.

.背景:糖尿病是一种复杂的疾病,需要采取多种策略控制血糖。最具挑战性的部分是获得健康的饮食习惯。我们需要让患者充分了解并参与到他们的疾病中来;为此,我们需要标准化、可靠的工具来评估这一人群的饮食习惯。方法:采用横断面设计,构建并验证糖尿病 2 型患者饮食习惯评估量表。方法:采用横断面设计,构建并验证 2 型糖尿病患者进食习惯评估量表。对列出的 63 个问题进行审查和统计分析,将其缩减为 30 个项目的量表,并应用于一家一级护理诊所的 495 名 2 型糖尿病患者。结果:最终版本包含 30 个项目,分布在 8 个维度上,在李克特量表上有 3 个回答选项,Cronbach's alpha 为 0.811。探索性因子分析显示因子载荷大于 0.30。结论:评价 2 型糖尿病患者饮食习惯的量表具有有效性和高可靠性,可用于该人群。
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引用次数: 0
Causal effects of vitamin D on leukemia risk: insights from two-sample Mendelian randomization analysis. 维生素 D 对白血病风险的因果效应:双样本孟德尔随机分析的启示。
IF 2.5 4区 医学 Q3 BUSINESS Pub Date : 2024-11-22 DOI: 10.20960/nh.05541
Shupeng Chen, Meiling Zhang, Yao Gao, Yingjian Zeng

Background: vitamin D plays a crucial role in immune regulation, anti-inflammatory processes, and tumor suppression, but its relationship with leukemia risk remains unclear. This study aims to evaluate the causal relationship between vitamin D levels and the risk of different types of leukemia through a two-sample Mendelian randomization (MR) analysis.

Methods: data from large-scale genome-wide association studies (GWAS) were used, and genetic variants associated with vitamin D were selected as instrumental variables. The relationship between vitamin D levels and the risk of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML) was examined. The inverse variance weighted (IVW) method was applied as the primary analytical approach. Heterogeneity was assessed through Cochran's Q test, pleiotropy was evaluated using the MR-Egger intercept, and sensitivity analyses were performed to ensure the robustness of the results.

Results: MR analysis showed a significant inverse association between serum 25-hydroxyvitamin D levels and the risk of CML (OR = 0.44, 95 % CI: 0.25-0.78, p = 0.005), suggesting a potential protective effect of vitamin D against CML. No significant causal relationships were found between vitamin D levels and the risks of AML, ALL, or CLL. Sensitivity analyses supported the robustness of these findings, with no evidence of heterogeneity or pleiotropy.

Conclusion: the findings indicate that higher vitamin D levels may reduce the risk of CML, while the effects on other types of leukemia require further investigation. The potential role of vitamin D in leukemia prevention warrants more mechanistic studies and clinical validation.

背景:维生素D在免疫调节、抗炎过程和肿瘤抑制中起着至关重要的作用,但其与白血病风险的关系尚不清楚。本研究旨在通过双样本孟德尔随机化(MR)分析来评估维生素D水平与不同类型白血病风险之间的因果关系。方法:使用大规模全基因组关联研究(GWAS)的数据,选择与维生素D相关的遗传变异作为工具变量。探讨维生素D水平与急性髓性白血病(AML)、急性淋巴细胞白血病(ALL)、慢性淋巴细胞白血病(CLL)、慢性髓性白血病(CML)发病风险的关系。采用方差反加权法(IVW)作为主要分析方法。通过Cochran’s Q检验评估异质性,使用MR-Egger截距评估多效性,并进行敏感性分析以确保结果的稳健性。结果:MR分析显示血清25-羟基维生素D水平与CML风险呈显著负相关(OR = 0.44, 95% CI: 0.25-0.78, p = 0.005),提示维生素D对CML有潜在的保护作用。没有发现维生素D水平与AML、ALL或CLL风险之间存在显著的因果关系。敏感性分析支持这些发现的稳健性,没有证据表明存在异质性或多效性。结论:研究结果表明,较高的维生素D水平可能会降低CML的风险,而对其他类型白血病的影响有待进一步研究。维生素D在白血病预防中的潜在作用需要更多的机制研究和临床验证。
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引用次数: 0
[Response to the Letter to the Editor: "The importance of social determinants in the detection of depressive symptoms and their relationship to tap water consumption"]. [回应致编辑的信:"社会决定因素在发现抑郁症状中的重要性及其与自来水饮用量的关系"]。
IF 2.5 4区 医学 Q3 BUSINESS Pub Date : 2024-11-22 DOI: 10.20960/nh.05555
María-Reyes Pérez-Fernández, María-Milagros Fernández-Varela, Natalia Fariñas-Valiña, Juan-Imeldo Rodríguez-Garrido, Miriam Vázquez-Campo
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引用次数: 0
Nutritional fulfillment behavior of pregnant women based on the health belief model theory in Indonesia. 基于健康信念模式理论的印度尼西亚孕妇营养满足行为。
IF 2.5 4区 医学 Q3 BUSINESS Pub Date : 2024-11-22 DOI: 10.20960/nh.05022
Aria Aulia Nastiti, Mira Triharini, Nofinda Widya Sari, Ni Ketut Alit Armini, Nursalam Nursalam, Sandeep Poddar

Introduction: malnutrition in pregnant women will cause impaired fetal development, premature delivery, impaired baby growth, and the risk of causing chronic disease. The Health Belief Model is used and has an important role in directing pregnant women to engage in preventive health behavior, namely preventing malnutrition.

Objective: this study aims to analyze the factors related to the nutritional fulfillment behavior of pregnant women based on the theory of the health belief model.

Methods: this research used correlational design with a cross-sectional approach. The total sample is 164 pregnant women. The variables were perceived susceptibility, perceived severity, perceived benefits, perceived barriers, cues to action, self-efficacy, and behavior of fulfilling the nutritional needs. Data were collected using a questionnaire and analyzed using Spearman's rho with a p-value ≤ 0.05.

Result: factors related to the behavior of fulfilling nutritional needs of pregnant women are, perceived benefits (p = 0.021), perceived barriers (p = 0.034) and cues to action (p = 0.032). Meanwhile, perceived susceptibility, perceived severity, and self-efficacy do not correlate with the nutritional fulfillment behavior of pregnant women.

Conclusion: factors related to the behavior of fulfilling nutritional needs are perceived benefits, perceived barriers, and cues to action. Future research is expected to develop a health belief model factor for intervention to improve behavior in fulfilling nutritional needs in pregnant women.

孕妇营养不良会造成胎儿发育受损、早产、婴儿生长受损,并有引起慢性疾病的危险。使用健康信念模型,并在指导孕妇从事预防性保健行为,即预防营养不良方面发挥重要作用。目的:基于健康信念模型理论,分析孕妇营养履行行为的相关因素。方法:本研究采用相关设计和横断面方法。样本总数为164名孕妇。变量包括感知易感性、感知严重性、感知益处、感知障碍、行动提示、自我效能和满足营养需求的行为。采用问卷法收集资料,采用Spearman’s rho进行分析,p值≤0.05。结果:影响孕妇营养需求行为的因素有:感知利益(p = 0.021)、感知障碍(p = 0.034)和行动提示(p = 0.032)。同时,感知易感性、感知严重性和自我效能感与孕妇的营养满足行为不相关。结论:与满足营养需求的行为相关的因素是感知到的益处、感知到的障碍和行动的提示。未来的研究有望开发一个健康信念模型因子,用于干预改善孕妇满足营养需求的行为。
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引用次数: 0
[Design and validation of an instrument to measure healthy habits and emotional state in adolescents]. [青少年健康习惯和情绪状态测量工具的设计与验证]。
IF 2.5 4区 医学 Q3 BUSINESS Pub Date : 2024-11-22 DOI: 10.20960/nh.05470
Verónica Martínez Lara, José Alberto Ramírez de León, Dionicio Morales Ramírez, Brian González Pérez

Introduction: obesity is a condition that increases the risk of presenting other non-communicable diseases, reducing life expectancy and quality of life in individuals. Its development involves a complex interaction of several factors, the main ones being inadequate food intake and lack of physical activity.

Objective: to design and validate a tool to identify eating habits, physical activity and emotional state in adolescents.

Methods: an observational study was carried out in 2 instances design and validation, using the Delphi method, taking as a basis for its design the 7 stages proposed by Sampieri. The design, based on the systematic review of the literature, was proposed by the coordinating group. Validation was carried out in 2 phases: the first by means of the criteria of judges, with the participation of 17 experts who evaluated the wording and relevance of each item, and the second by means of statistical analysis estimating the Aiken V coefficient, binomial tests, Cronbach's Alpha and McDonald's Omega. It was applied to a sample of 673 adolescents from the southern area of the state of Tamaulipas, Mexico.

Results: an instrument composed of 46 items in 3 dimensions was obtained. In the validation, binomial tests were estimated, showing a significance of 0.000, which indicates that the questions are correlated. Likewise, the Aiken V coefficient was estimated for all the items, which presented a value > 0.7, establishing adequate content validity for each one of them. Finally, the reliability tests estimated by means of Cronbach's Alpha and McDonald's Omega obtained an overall value of 0.777, which indicates that the instrument is reproducible and consistent.

Conclusions: the tool generated presented validity and reliability indicating that it is suitable for its application in the assessment of risk in healthy habits of adolescents (diet and physical activity) and of alteration in their emotional state.

简介:肥胖是一种会增加患其他非传染性疾病的风险、降低个人预期寿命和生活质量的病症。它的发展涉及几个因素的复杂相互作用,主要是食物摄入不足和缺乏体育活动。目的:设计并验证青少年饮食习惯、身体活动和情绪状态的识别工具。方法:以Sampieri提出的7个阶段为设计依据,采用德尔菲法进行2个实例设计和验证的观察性研究。该设计基于对文献的系统回顾,由协调小组提出。验证分两个阶段进行:第一阶段通过评委标准,由17位专家参与,对每个条目的措辞和相关性进行评估;第二阶段通过统计分析估计Aiken V系数、二项检验、Cronbach’s Alpha和McDonald’s Omega。它被应用于来自墨西哥塔毛利帕斯州南部地区的673名青少年样本。结果:获得了一个由46个项目组成的三维仪器。在验证中,二项检验估计,显着性为0.000,这表明问题是相关的。同样,对所有项目进行Aiken V系数估计,其值为> 0.7,为每个项目建立了足够的内容效度。最后,通过Cronbach's Alpha和McDonald's Omega估计的信度检验得到的总体值为0.777,表明该仪器具有可重复性和一致性。结论:所生成的工具具有一定的效度和信度,适用于青少年健康习惯(饮食和体育活动)风险评估和青少年情绪状态变化风险评估。
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引用次数: 0
[Maternal perception of hunger-satiety signals and their impact on feeding and nutritional status of infants in Mexico]. [墨西哥产妇对饥饿--饱足信号的感知及其对婴儿喂养和营养状况的影响]。
IF 2.5 4区 医学 Q3 BUSINESS Pub Date : 2024-11-12 DOI: 10.20960/nh.05438
Rosario Edith Ortiz Félix, Patricia Enedina Miranda Félix, Félix Gerardo Buichia Sombra, Liliana Estefanía Ramírez-Jaime, Milton Carlos Guevara Valtier, Velia Margarita Cárdenas-Villarreal

Introduction: nutrition during the first two years of life is crucial for the physical, cognitive, and emotional development of children. This study aimed to: 1) associate maternal perception of hunger and satiety signals with the type of feeding; 2) associate maternal perception of hunger and satiety signals with the infant's weight status; and 3) determine the influence of feeding type on the infant's BMI-for-age.

Methods: a descriptive correlational cross-sectional study was conducted with 424 mother-infant dyads in Sinaloa, Mexico, using systematic random sampling. Mothers completed questionnaires on feeding practices and perception of hunger and satiety signals. Anthropometric data of the infant were measured, and the influence of feeding type on the infant's BMI-for-age z-score was analyzed using multiple linear regression.

Results: 45.8 % of mothers reported a low perception of hunger and satiety signals. 30.2 % of infants were overweight. Mothers with a high perception of signals reported a lower proportion of overweight infants. Mixed feeding and early introduction of complementary foods significantly influence the increase in infant zIMC/age score.

Conclusions: maternal perception of hunger and satiety signals influences the infant's weight status. Mixed feeding and early introduction of complementary foods increase the risk of overweight in infants. It is crucial to promote adequate perception of these signals to prevent nutritional problems in early childhood.

导言:出生后头两年的营养对儿童的身体、认知和情感发育至关重要。本研究旨在1) 将母亲对饥饿和饱腹信号的感知与喂养类型联系起来;2) 将母亲对饥饿和饱腹信号的感知与婴儿的体重状况联系起来;3) 确定喂养类型对婴儿适龄体重指数的影响。母亲们填写了有关喂养方式以及对饥饿和饱腹信号感知的问卷。对婴儿的人体测量数据进行了测量,并使用多元线性回归分析了喂养方式对婴儿的 BMI 年龄 Z 值的影响:结果:45.8%的母亲表示对饥饿和饱腹信号的感知能力较低。30.2%的婴儿超重。对饥饿和饱腹信号感知较强的母亲报告的婴儿超重比例较低。结论:母亲对饥饿和饱腹信号的感知会影响婴儿的体重状况。混合喂养和过早添加辅食会增加婴儿超重的风险。促进对这些信号的充分感知对于预防幼儿期营养问题至关重要。
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引用次数: 0
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