This work presents a highly efficient multilayer biosensor based on dual‑resonance Tamm plasmon polaritons (TPPs), designed for ultra‑sensitive detection of lung cancer cells. The sensor employs a thin metal-dielectric interface integrated atop an all-dielectric photonic crystal, enabling two ultra-narrowband resonances under normal incidence without the use of coupling prisms or gratings. Numerical modeling using the transfer matrix method (TMM) confirms strong field confinement at the metal-sample interface, resulting in high spectral selectivity and dual resonance modes with full width at half maximum (FWHM) values of 0.133 nm and 0.143 nm. The corresponding quality factors (Q) reach 4029 and 3778, and figures of merit (FoM) are 90 RIU−1 and 106 RIU−1, respectively. The device exhibits sensitivities of 12 nm/RIU and 15.1 nm/RIU for a refractive index variation of ΔnS = 0.01. For biological testing with A549 lung cells, resonance shifts of 0.20 nm and 0.23 nm are observed between healthy (n = 1.3662) and cancerous (n = 1.3568) samples. Considering a spectrometer resolution of 0.1 nm, the minimum detectable refractive index changes are 8.3 × 10−3 RIU and 6.6 × 10−3 RIU for the two resonances. Due to its ultra‑narrow linewidth, high FoM, label‑free operation, and compatibility with standard thin‑film fabrication, the proposed TPP‑based biosensor offers a compact and accurate platform for real‑time optical cancer diagnostics.
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