One Health最新文献

{"title":"Occurrence of extended- spectrum β-lactamases and ertapenem- mono- resistance in Escherichia coli isolated from diarrheal calves","authors":"Lívia Karahutová,&nbsp;Dobroslava Bujňáková","doi":"10.1016/j.onehlt.2025.101138","DOIUrl":"10.1016/j.onehlt.2025.101138","url":null,"abstract":"<div><div>The rise of antimicrobial resistance, particularly against last-resort antibiotics, is a major global health challenge. To address this crisis, implementation of the One Health concept, including surveillance across the environment, public and veterinary health sectors is strongly recommended. This study aimed to assess the antibiotic resistance of <em>Escherichia coli</em> strains isolated from faeces of diarrheal calves on eight farms in eastern Slovakia. We particularly focused on isolates carrying extended-spectrum beta-lactamases (ESBL), carbapenemases, fluoroquinolone resistance, and mobile colistin resistance genes<strong>.</strong></div><div>High resistance rates were observed for penicillins (ampicillin: 76 %; ampicillin + sulbactam: 50 %) and tetracycline (73 %), followed by quinolones (54 %), sulphonamides (46 %), aminoglycosides (tobramycin: 29 %; gentamicin: 44 %), and second and third generation cephalosporins (cefuroxime: 29 %; cefotaxime + clavulanic acid: 1 %; cefotaxime: 22 %). Sporadic resistance to fourth generation cephalosporins (2 %) and ertapenem mono-resistance (5 %) was also noted. Multidrug resistance (MDR) was observed in 71 % of the isolates. Automated interpretative reading of the antibiogram revealed six resistance mechanisms. The most concerning was the CTX-M type ESBL, with confirmed presence of the <em>bla</em>_CTX-M-1, <em>bla</em>_CTX-M-2, and <em>bla</em>_CTX-M-9 genes, along with MDR and mobile gene elements (<em>int</em>1 and <em>tn</em>3), which facilitate the horizontal spread of resistance genes. Additionally, two <em>bla</em>_CMY-2-positive isolates were observed with the <em>int</em>1 and <em>tn</em>3 genes. Genes responsible for resistance to other antimicrobial classes (such as tetracyclines, fluoroquinolones, and aminoglycosides) were also detected.</div><div>Our results suggest that calves may serve as a reservoir for MDR, ESBL/AmpC, and ertapenem-mono-resistant strains of <em>E. coli</em>, posing a potential public health risk through the horizontal spread of resistance genes.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101138"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between the 2022 global mpox outbreak and multifaceted factors: A multi-geographical retrospective study","authors":"Yuxi Ge ,&nbsp;Yifei Wang ,&nbsp;Ziqin Zhou ,&nbsp;Zhirui Zhang ,&nbsp;Yunyu Tian ,&nbsp;Yun Feng ,&nbsp;Peiyi Wu ,&nbsp;Yuxin Wang ,&nbsp;Ziyan Liu ,&nbsp;Bingying Li ,&nbsp;Zengmiao Wang","doi":"10.1016/j.onehlt.2025.101224","DOIUrl":"10.1016/j.onehlt.2025.101224","url":null,"abstract":"<div><div>Unlike prior travel-related mpox cases, the 2022 outbreak of mpox virus (MPXV) clade IIb outside endemic regions posed a significant global health threat. Despite growing recognition of the One Health relevance of mpox, the factors driving this unprecedented outbreak and their quantitative effects remain not fully understood. This study aims to identify key factors across various geographical scales to inform future mpox mitigation policies within One Health framework. We built logistic regression models to assess the association of 18 covariates—including socioeconomic, demographic, and human behaviors (e.g., urbanization, sexual behavior, immunity, mobility and contact intensity) —with mpox outbreak probability in the United States, England, Brazil, and globally. We also examined temporal trends over the past decade. Our analysis revealed positive associations between mpox cases and urbanization rates (United States: <em>R</em> = 0.43; England: <em>R</em> = 0.25; Brazil: <em>R</em> = 0.52; all <em>P</em> &lt; 0.05) and the proportion of lesbian, gay, bisexual, and transgender (LGBT) individuals (United States: <em>R</em> = 0.39; England: <em>R</em> = 0.72; both <em>P</em> &lt; 0.05; Brazil: <em>R</em> = 0.26, <em>P</em> = 0.18). Conversely, smallpox vaccination coverage showed a negative association with mpox cases (United States: <em>R</em> = -0.25, <em>P</em> = 0.08; England: <em>R</em> = -0.52). Similar trends were observed globally. Mpox outbreak probability increased globally over the past decade. Our findings highlight the role of long-term human behavior changes in MPXV clade IIb outbreaks. From a One Health perspective, these results suggest that ongoing attention to behavioral factors, alongside ecological and social contexts, may help improve understanding and prediction of outbreak dynamics.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101224"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes and risk practices on echinococcosis in Aysén District, Chile","authors":"Nicole Sepulveda ,&nbsp;Marcela Fresno ,&nbsp;Yanina Poblete ,&nbsp;Hernan Cañon Jones","doi":"10.1016/j.onehlt.2025.101155","DOIUrl":"10.1016/j.onehlt.2025.101155","url":null,"abstract":"<div><div>Echinococcosis, a zoonotic disease caused by <em>Echinococcus granulosus</em> and <em>E. multilocularis</em>, presents significant health and economic challenges globally. This study assessed knowledge, attitudes, and practices regarding cystic echinococcosis in the rural communities, health professionals, and educators of Capitán Prat Province, Aysén Region, Chile. A survey of 243 participants revealed a high general awareness of the disease (81.6 %), with significant variations in knowledge levels and practices across sectors. Risk behaviours, such as allowing dogs to roam freely and improper disposal of animal viscera, were prevalent, particularly in rural areas. While preventive measures, including deworming and education, were highly valued, gaps in their consistent application persisted. The findings underscore the need for targeted educational campaigns and culturally sensitive interventions to address behavioural risk factors. Strengthening One Health initiatives through community engagement and intersectoral collaboration is critical to reducing the burden of hydatidosis in endemic regions.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101155"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The seasonality of respiratory syncytial virus and its associations with meteorological factors in Hong Kong, 2014–2023","authors":"Qian Xiong ,&nbsp;Zhuyao Rong ,&nbsp;Jinjun Ran ,&nbsp;Xiang Ren ,&nbsp;Li Li","doi":"10.1016/j.onehlt.2025.101175","DOIUrl":"10.1016/j.onehlt.2025.101175","url":null,"abstract":"<div><h3>Background</h3><div>Respiratory syncytial virus (RSV) is a common respiratory virus that causes respiratory diseases in all ages and causes severe diseases mainly among children and older adults. Understanding the seasonal pattern of RSV and its influencing factors is crucial for policy makers to optimize the timing of RSV immunization strategies. We explored the RSV seasonality and its associations with meteorological factors in Hong Kong from 2014 to 2023.</div></div><div><h3>Methods</h3><div>We collected weekly RSV surveillance data in Hong Kong between 2014 and 2023 from Centre for Health Protection (CHP) of Hong Kong. Three different approaches were applied to explore the RSV seasonality including the 50th percentile method, the average annual percentage (AAP) method, and the 2 % threshold method. A generalized additive model was used to explore the associations between RSV positive rate and meteorological factors.</div></div><div><h3>Results</h3><div>During 10-year study period, 44,722 specimens were positive for RSV with a positive rate of 2.81 % in Hong Kong. The RSV epidemic varied year-on-year, with annual and biannual epidemics observed. The three approaches identified similar RSV epidemic in Hong Kong, a total of 9 RSV epidemics were found. The RSV epidemics mainly occurred from mid-February to late September, with an average duration of approximately 6 months during the study years. We found that mean temperature was positively associated with RSV positive rate, while mean dew point temperature showed a negative association.</div></div><div><h3>Conclusions</h3><div>RSV epidemic varied year-on-year in Hong Kong, the 2 % threshold is recommended as an alert threshold for RSV epidemics. A One Health perspective might enhance future prevention strategies by incorporating broader environmental and intersectoral factors.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101175"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High toxocariasis seroprevalence in a tri-border indigenous community (Brazil, Paraguay and Argentina): A One Health perspective","authors":"Isabella Braghin Ferreira ,&nbsp;Roberto Teixeira de Souza Filho ,&nbsp;Susana Angélica Zevallos Lescano ,&nbsp;Rogério Giuffrida ,&nbsp;Daniele Rodrigues ,&nbsp;Suelen Teixeira de Faria Resende ,&nbsp;Fabiano Borges Figueiredo ,&nbsp;Louise Bach Kmetiuk ,&nbsp;Andrea Pires dos Santos ,&nbsp;Alexander Welker Biondo ,&nbsp;Vamilton Alvares Santarém","doi":"10.1016/j.onehlt.2025.101106","DOIUrl":"10.1016/j.onehlt.2025.101106","url":null,"abstract":"<div><div>Toxocariasis, a neglected parasitic zoonosis, has mostly affected vulnerable populations of subtropical and tropical regions worldwide. In addition to vulnerability, indigenous communities have long existed before bordering areas, particularly in South American countries, leading to cultural isolation, migratory and environmental concerns, lately associated to low human infrastructure and lack of healthcare policies. Accordingly, the study herein has serosurveyed anti-<em>Toxocara</em> spp. antibodies in indigenous persons, and surveyed <em>Toxocara</em> spp. in their dog and soil samples from a Guarani-Mabyá indigenous community located in a tri-border area of Brazil, Paraguay and Argentina. Overall, seropositivity was detected in 246/258 (95.3 %; 95 % CI: 92.1–97.3) indigenous persons, with no statistically associated risk factor to seropositivity, likely due to the highest human toxocariasis seroprevalence reported to date worldwide. Although detected in only 8/124 (6.5 %) dog feces samples, <em>Toxocara</em> spp. eggs were present in 13/42 (30.9 %) soil samples of common areas and 17/32 (53.1 %) of households, molecularly identified as <em>T. canis</em> by DNA amplification. The significant number of infective <em>Toxocara</em> spp. eggs found in the soil samples has reinforced the role of daily environmental exposure in sustaining transmission within this community, which may reflect the pattern of disease status in other nearby indigenous communities. Moreover, migratory behavior of Guarani ethnicity across the tri-border may have spread infection to other border indigenous communities of Brazil, Paraguay and Argentina.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101106"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clam research in Nunavut: A scoping review of the literature","authors":"Stephanie Gerend ,&nbsp;Amy Caughey ,&nbsp;Marina Banuet-Martinez ,&nbsp;Rachael Vriezen ,&nbsp;Karen Shapiro ,&nbsp;Rob Jamieson ,&nbsp;Theresa Koonoo ,&nbsp;Sherilee L. Harper","doi":"10.1016/j.onehlt.2025.101168","DOIUrl":"10.1016/j.onehlt.2025.101168","url":null,"abstract":"<div><div>Clams are an important country food with cultural, environmental, and health significance for Inuit communities in Nunavut. We analyzed the extent, range, and nature of published research on clams in Nunavut, Canada. We used a systematic and transparent scoping review methodology by applying a search string across three databases to identify potentially relevant articles. Two independent reviewers screened the titles and abstracts (phase 1), followed by article full texts (phase 2), using inclusion and exclusion criteria. Data were extracted from 25 included articles and descriptively analyzed. We also conducted thematic analysis to identify overarching themes, ideas, and gaps. The most frequent topic of research was using clams to understand ecological histories (<em>n = 10/25; 40 %</em>), followed by the biology of clams (<em>n = 7/25; 28 %</em>), environmental indicators (<em>n = 6/25; 20 %</em>), and foodborne illnesses (<em>n = 2/25; 8 %</em>). We did not identify any articles that investigated the nutritional value of clams, food security, or Indigenous knowledges. Out of all included articles, just over one-quarter described Inuit involvement in the research (<em>n = 7/25;</em> 28 %<em>)</em>. Our review highlights and documents how clam research has predominantly focused on natural and environmental sciences in Nunavut. Published research that explores health and social dimensions of clams in Nunavut has so far been limited. Given that clams are not only an ecologically important species but also hold health and cultural significance for communities in Nunavut, further research to capture a diversity of topics – as well as the intersection among topics – could support food-related programming, policies, and decisions intended to foster Inuit wellbeing.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101168"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144920148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The alert for emergence of pig-associated MRSA ST 398 in multi-regions China","authors":"Mingquan Cui ,&nbsp;Hejia Wang ,&nbsp;Ningning Han ,&nbsp;Wenli Tang ,&nbsp;Xiangbin Song","doi":"10.1016/j.onehlt.2025.101132","DOIUrl":"10.1016/j.onehlt.2025.101132","url":null,"abstract":"<div><div>Livestock-associated Methicillin-resistant <em>Staphylococcus aureus</em> (LA-MRSA) lineage ST398 presents a notable public health risk through its transmission from pigs to humans. This study characterizes phenotypic and genomic features of pig-associated MRSA ST398 isolates in China. Through surveillance (2015–2021) of 296 <em>S. aureus</em> isolates from major pork-producing regions, we identified 14 MRSA isolates in Zhejiang, Fujian, Guangdong, and Shanxi provinces, with 12 (85.7 %) belonging to the ST398 lineage. These isolates displayed two genetic profiles: t011-SCC<em>mec</em> V (10/12) and t571-SCC<em>mec</em> XII (2/12), and exhibited multidrug resistance to penicillin, oxacillin, cefoxitin, erythromycin, and clindamycin. Phylogenetic analysis revealed three critical findings: (1) clonal dissemination within Shanxi (0–48 SNPs), (2) potential interprovincial spread between geographically distant regions (Shanxi-Qinghai, 17–44 SNPs), and (3) concerning genetic linkage (70 SNPs) between a Zhejiang isolate and European ST398 isolate. These results underscore the urgent need for integrated pork supply chain surveillance strategies to monitor this emerging zoonotic pathogen.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101132"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptospirosis? An epidemiologic investigation following the historic 2024 floods in Rio Grande do Sul, Brazil","authors":"Christopher J. Hernandez ,&nbsp;Greici Gunzel ,&nbsp;Clarice Ritter ,&nbsp;Roberto Carlos Freitas Bugs ,&nbsp;Thiago Rocha ,&nbsp;Trevon Fuller ,&nbsp;Patricia Brasil ,&nbsp;Ivana Rosângela dos Santos Varella ,&nbsp;Maria da Graça Pimenta Machado ,&nbsp;Carina Guedes Ramos ,&nbsp;Ângela Piccoli Ziegler ,&nbsp;Breno Riegel Santos ,&nbsp;Marineide Gonçalves de Melo ,&nbsp;Karin Nielsen-Saines","doi":"10.1016/j.onehlt.2025.101146","DOIUrl":"10.1016/j.onehlt.2025.101146","url":null,"abstract":"<div><div>In May 2024, the Brazilian state of Rio Grande do Sul experienced an historic flood that affected millions of people. Hundreds of thousands of people were displaced by the record-breaking flood waters, exposing them to water-borne pathogens, including leptospirosis. With concern for an outbreak, local efforts focused on identifying and treating any potential cases of leptospirosis. Using data from a local database for people presenting with signs and symptoms compatible with leptospirosis, we conducted a retrospective-prospective cohort study to estimate the incidence of confirmed cases. Of 539 patients reported to the database, a total of 485 patients were tested for leptospirosis and 303 were tested for Dengue (with 283 testing for both pathogens). We found 17 (3.5 %) confirmed cases of leptospirosis and 102 (33.7 %) confirmed cases of dengue fever. Most tested negative for both, with several confirmed cases of Hantavirus, Influenza A, and HIV. Although there were no significant differences between diagnoses and exposure risk factors, we did find several clinical differences, including headache, respiratory symptoms, diarrhea, acute kidney injury, jaundice, bleeding diathesis, and pulmonary hemorrhage. Leptospirosis was also found to be significantly associated with adverse clinical outcomes when compared to both dengue and the Unrelated/Unknown illness group and more likely to be of the male sex. These data reinforce the need for broader systematic surveillance for pathogens that may circulate in the event of major environmental disasters. Further, stronger diagnostics are urgently needed to distinguish between the causes of largely febrile outbreak in the face of a changing climate.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101146"},"PeriodicalIF":4.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National action plan on antimicrobial resistance in selected Asia-Pacific low- and middle-income countries: Perspectives of One Health stakeholders","authors":"Yasodhara D. Gunasekara ,&nbsp;Kirsten E. Bailey ,&nbsp;Ri O. Scarborough ,&nbsp;Anna E. Sri ,&nbsp;Mauricio J.C. Coppo ,&nbsp;James R. Gilkerson ,&nbsp;Glenn F. Browning ,&nbsp;Laura Y. Hardefeldt","doi":"10.1016/j.onehlt.2025.101259","DOIUrl":"10.1016/j.onehlt.2025.101259","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) is a One Health problem worldwide, with low and middle-income countries (LMICs) identified as hotspots for AMR development. Countries have created National Action Plans on AMR (NAP-AMR) to address the growing problem; however, studies on the progression of NAP-AMR implementation are scarce. This study explores the current status of the implementation and impact of NAP-AMR in selected LMICs in the Asia-Pacific region through a One Health lens. In total, 102 experts from Bhutan, Nepal, Pakistan, Timor-Leste and Papua New Guinea were enrolled as the study population. Their perspectives on the level of implementation of NAP-AMR were collected via an online questionnaire, and an 80 % response rate was obtained. Participants felt that NAP-AMR implementation was more advanced in human health than in animal or environmental health. Stakeholders perceived to be well informed also tended to be engaged more actively in implementing the responsibilities outlined in the NAP-AMR. Nearly all participants believed that their country needed local antimicrobial prescribing guidelines for humans (94 %) and animals (86 %). Unrestricted access to antimicrobials and poor implementation status of surveillance systems across human, animal and environmental sectors were identified as areas where more progress is needed. Participants' beliefs about the current level of training and awareness related to AMR, as well as current AMR and AMU surveillance, was different from the Quadripartite AMR country self-assessment survey. Further studies need to be conducted to explore the barriers to NAP-AMR implementation in this setting. This study highlights the importance of systematic and transparent monitoring and evaluation frameworks across multiple One Health sectors, to assess progress on implementation of action plans and identify gaps for further investment or intervention. The importance of co-designing monitoring and evaluation frameworks with input from diverse AMR stakeholders across One Health domains was also identified as critical to ensuring the relevance of these frameworks and an equitable approach.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101259"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening intersectoral cooperation for control and integrated surveillance of rabies in Uganda: A multistakeholder engagement workshop","authors":"Rabina Ghimire ,&nbsp;Samuel George Okech ,&nbsp;Anna S. Fahrion ,&nbsp;Terence Odoch ,&nbsp;Jan Matern ,&nbsp;Tina Bohnes ,&nbsp;Nathalie J. Vielle ,&nbsp;Mathew Muturi ,&nbsp;Johanna Pauline Wiethoff ,&nbsp;Maria Flavia Nakanjako ,&nbsp;Frederic Lohr ,&nbsp;Prahors Ung ,&nbsp;Chheng Tann ,&nbsp;Simon Peter Alubbe ,&nbsp;Anna Rose Ademun ,&nbsp;John Opolot ,&nbsp;Fred Monje ,&nbsp;Judith Nanyondo Semanda ,&nbsp;Dickson Akankwatsa ,&nbsp;Lilian Wambua ,&nbsp;Sonja Hartnack","doi":"10.1016/j.onehlt.2025.101206","DOIUrl":"10.1016/j.onehlt.2025.101206","url":null,"abstract":"<div><div>Rabies is a prioritized zoonotic disease and significant public health threat in Uganda. Despite Uganda's commitment to the global “Zero-by-30” goal and a validated National Rabies Elimination Strategy (NRES), implementation has been hindered by fragmented surveillance, limited intersectoral coordination, and lack of operationalization of control plans. To address these challenges, a participatory multisectoral workshop was conducted by the Schnell Einsetzbare Expertengruppe Gesundheit and eRabies project team, in collaboration with Makerere University, the Ministry of Agriculture, Animal Industry and Fisheries (MAAIF), and the Ministry of Health (MOH). The workshop brought together 49 participants from national, subnational, and international institutions to strengthen intersectoral cooperation, assess NRES implementation, and define next immediate steps for rabies control. The primary output was a structured SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis of NRES implementation, across four thematic areas: Governance, Coordination, and Risk Communication; Rabies Prevention and Control; Field and Laboratory Surveillance and Data Management, and Training and Operational Research. Insights from the SWOT analysis informed a one-year log frame outlining 10 prioritized objectives and 26 targeted activities, each linked to success indicators and timelines. Early follow-up actions included piloting a digital application for integrated bite case management in four selected districts, specialized rabies diagnostic training, a national rabies research scoping review, and targeted mass dog vaccination campaigns. Despite these advancements, broader implementation of the plan remains inconsistent. Over a year later, activities such as vaccination coverage assessment, post-exposure prophylaxis procurement and distribution, and sustained community engagement have not progressed beyond planning or lack documentation. Sustained political commitment, dedicated financing, and strengthened coordination at both national and subnational levels are critical to overcome existing challenges and ensure initial momentum translates into lasting impact. The workshop outputs offer a practical, stakeholder-driven framework to guide national priorities, aligned with the NRES and goal of rabies elimination in Uganda.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"21 ","pages":"Article 101206"},"PeriodicalIF":4.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145104199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}