One Health最新文献_第3页

Invasive alien mammals pose zoonotic risks to human health in Europe 外来入侵哺乳动物对欧洲人类健康构成人畜共患风险

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-19 DOI: 10.1016/j.onehlt.2025.101307

Paola Monguilod , Belinda Gallardo

The rise in zoonotic diseases is accelerating, with climate change expected to further intensify this trend. Invasive Alien Species (IAS) play an important role in the emergence and spread of zoonotic diseases by introducing both existing and novel pathogens to the regions they invade. Despite this, research on the role of IAS in spreading zoonotic diseases remains limited. Our study investigated the zoonotic risks posed by eight invasive mammal species prioritized for management in Europe. On average, each species was found to transmit 16 pathogens capable of causing severe diseases in humans, including Echinococcosis, Leptospirosis, Lyme neuroborreliosis, and Encephalitis.

We identified central and western Europe as significant disease hotspots. Climate change is facilitating the expansion of IAS into new areas, as warmer temperatures make previously inhospitable regions suitable. Future projections indicate a northeastward shift in their suitability by 2050. These changes vary by species, with the Siberian chipmunk losing up to 45 % of its suitability, while the gray squirrel could see a 26 % increase under a high-emissions scenario.

Finally, we found that 71 % of the human population lives in areas highly suitable for IAS establishment. Our findings underscore the health risks associated with IAS and highlight the need for further research into their role in disease dynamics. Addressing this issue is essential for developing effective public health strategies and mitigating future zoonotic disease outbreaks.

人畜共患疾病的增加正在加速，预计气候变化将进一步加剧这一趋势。外来入侵物种（IAS）通过将现有的和新的病原体引入它们所入侵的地区，在人畜共患疾病的出现和传播中发挥重要作用。尽管如此，关于IAS在人畜共患疾病传播中的作用的研究仍然有限。本研究调查了欧洲优先管理的8种入侵哺乳动物所带来的人畜共患病风险。平均而言，每个物种被发现传播16种能够引起人类严重疾病的病原体，包括棘球蚴病、钩端螺旋体病、莱姆病神经螺旋体病和脑炎。我们确定中欧和西欧是重要的疾病热点。气候变化正在促进IAS扩展到新的领域，因为温度升高使以前不适宜居住的地区变得适宜。未来的预测表明，到2050年，它们的适宜性将向东北转移。这些变化因物种而异，西伯利亚花栗鼠失去了高达45%的适宜性，而在高排放情景下，灰松鼠的适宜性可能会增加26%。最后，我们发现71%的人口生活在非常适合建立IAS的地区。我们的研究结果强调了与IAS相关的健康风险，并强调需要进一步研究它们在疾病动态中的作用。解决这一问题对于制定有效的公共卫生战略和减轻未来人畜共患疾病暴发至关重要。

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引用次数: 0

Tracing the roots of One Health principles in nursing practice 在护理实践中追溯同一个健康原则的根源

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-19 DOI: 10.1016/j.onehlt.2025.101306

Júlio Belo Fernandes , Sónia Fernandes , Cidália Castro , Diana Vareta

This article examines the historical roots of the One Health concept and highlights its deep convergence with Florence Nightingale's Environmental Theory. Although One Health gained prominence in the early 2000s, its intellectual foundations are much older, encompassing Indigenous knowledge systems, nineteenth-century public health, and the work of Virchow, Osler, and Schwabe. Through a historical–conceptual analysis of Nightingale's writings and key One Health milestones, the article shows how her emphasis on environmental determinants, stewardship of natural and built environments, systematic observation, statistical evidence, and coordinated cross-sectoral action anticipated core One Health principles. Five areas of convergence are identified: prevention focused on environmental determinants, environmental stewardship, data-informed decision making, transdisciplinary collaboration, and continuous system improvement. The article argues that Nightingale's legacy positions nursing as a strategic actor in the local implementation of One Health, particularly in designing therapeutic and healthy environments and integrating environmental indicators into care, governance, and health policy.

本文考察了“一个健康”概念的历史根源，并强调了它与弗洛伦斯·南丁格尔的环境理论的深度趋同。尽管“同一健康”在21世纪初获得了突出的地位，但它的知识基础要古老得多，包括土著知识体系、19世纪的公共卫生，以及维尔肖、奥斯勒和施瓦贝的工作。通过对南丁格尔的著作和关键的“一个健康”里程碑的历史概念分析，文章展示了她对环境决定因素、自然和建筑环境管理、系统观察、统计证据和协调跨部门行动的强调如何预测了“一个健康”的核心原则。确定了五个趋同领域：以环境决定因素为重点的预防、环境管理、基于数据的决策、跨学科合作和持续的系统改进。文章认为，南丁格尔的遗产将护理定位为“一个健康”在当地实施中的战略角色，特别是在设计治疗和健康环境以及将环境指标纳入护理、治理和卫生政策方面。

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引用次数: 0

A claim for plant health as a key component of the one health concept 声称植物健康是一个健康概念的关键组成部分

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-18 DOI: 10.1016/j.onehlt.2025.101304

Ramon Albajes , María M. López , Rafael M. Jiménez Díaz

The concept of health has historically been more closely linked to the well-being of humans than to that of animals, plants or the environment. In contrast, the One Health concept, which emerged in recent decades, generally recognizes the interdependence of only three of its four components: humans, wild and domestic animals, and the environment, but plants have often been overlooked in this analysis. Because plant health has been undervalued within the One Health framework, we emphasize in this review its importance in ensuring food security and safety, two key issues in human and animal health, as highlighted in several of the United Nations SDG. Food production, marketing and consumption use a significant portion of the environment's natural resources, and plant health technology must ensure their sustainable use while safeguarding environmental health. We summarize the relationships between the four components of One Health, highlighting the development of antimicrobial resistance in human, animal and plant pathogens, and the resistance to plant protection products among plant pests, diseases and weeds. Three external drivers significantly influence plant health and One Health in the last decades: climate change, invasive alien species, and the international armed conflicts. The main reported effects of climate change on plant health include the shifts in distribution area, biology and life cycles of harmful organisms as well as plant-pest interactions. Another major factor compromising the sustainability of current plant health technology is the introduction and establishment of alien organisms affecting vegetables resulting from the increasing globalization of food trade, human labour and tourism.These challenges underscore the need to approach One Health at broader scales, beyond individual organisms or populations, as well as intensifying studies on plant health, to effectively address holistically the complex, interconnected risks affecting global health.

从历史上看，健康的概念与人类的福祉的联系比与动物、植物或环境的联系更紧密。相比之下，近几十年来出现的“同一个健康”概念，通常只承认其四个组成部分中的三个相互依存：人类、野生动物和家畜以及环境，但在这一分析中，植物经常被忽视。由于植物健康在“同一个健康”框架内被低估，我们在本次审查中强调其在确保粮食安全和安全方面的重要性，这是人类和动物健康的两个关键问题，正如联合国若干可持续发展目标所强调的那样。粮食生产、销售和消费使用了很大一部分环境自然资源，植物健康技术必须确保这些资源的可持续利用，同时保护环境健康。我们总结了“同一个健康”的四个组成部分之间的关系，重点介绍了人类、动物和植物病原体抗微生物药物耐药性的发展，以及植物病虫害和杂草对植物保护产品的抗性。近几十年来，三个外部驱动因素显著影响植物健康和“同一个健康”：气候变化、外来入侵物种和国际武装冲突。已报道的气候变化对植物健康的主要影响包括有害生物的分布区域、生物学和生命周期的变化以及植物与害虫的相互作用。影响目前植物保健技术可持续性的另一个主要因素是粮食贸易、人力劳动和旅游业日益全球化所导致的影响蔬菜的外来生物的引进和建立。这些挑战突出表明，需要在更广泛的范围内，超越个别生物体或群体，以及加强对植物健康的研究，以有效地全面解决影响全球健康的复杂、相互关联的风险。

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引用次数: 0

Metagenomic surveillance of tick-borne pathogens and microbiomes in Huntingdon County, Pennsylvania 宾夕法尼亚州亨廷顿县蜱传病原体和微生物组的宏基因组监测

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-18 DOI: 10.1016/j.onehlt.2025.101305

Andrew Buonaccorsi , Brittney N. McMullen , Brie Builder , Kelliann Drummond , Sarah Halteman , Jeremy Chen See , Evan Thomas , Alexa Viands , Sarah Worley , Justin R. Wright , Jill Keeney , Regina Lamendella

The rise in tick populations across the United States has contributed to a surge in tick-borne diseases, with Pennsylvania ranking among the highest in reported cases. To better understand local pathogen prevalence and microbial community structure, an integrative study of ticks collected from ten recreational trails in Huntingdon County, Pennsylvania during the summer of 2023 was conducted. A total of 96 ticks were sampled, with 33 PCR-positive specimens selected for shotgun metagenomic sequencing. Pathogen screening via qPCR detected Borreliella burgdorferi, Borrelia miyamotoi, Babesia spp., and Anaplasma phagocytophilum. Shotgun metagenomics revealed a broader diversity of tick-borne pathogens, including Rickettsia and Ehrlichia spp., and demonstrated increased sensitivity by detecting low-abundance pathogens in samples that were PCR-negative. Co-infections were common, and multivariate statistical analysis identified significant associations between environmental variables (e.g., humidity, time of day, land cover) and microbial diversity and predicted gene function. Notably, diversity was higher in ticks collected during early afternoon and from northern sites. Co-occurrence network analysis showed Rickettsia as a central taxon with multiple significant positive associations with other microbes while other pathogens were largely absent or peripheral. These findings underscore the enhanced resolution of metagenomic approaches for pathogen detection and the value of combining molecular surveillance with ecological metadata. Our study provides critical insights into local tick microbiomes and pathogen prevalence, which may inform public health interventions and vector management strategies in central Pennsylvania.

美国各地蜱虫数量的增加导致了蜱传疾病的激增，宾夕法尼亚州是报告病例最多的州之一。为了更好地了解当地的病原体流行情况和微生物群落结构，研究人员于2023年夏天在宾夕法尼亚州亨廷顿县的十条休闲小径上收集了蜱虫。共采集96只蜱，其中pcr阳性33只进行鸟枪宏基因组测序。病原qPCR筛选检测到伯氏疏螺旋体、宫本氏疏螺旋体、巴贝斯虫和嗜吞噬细胞无形体。霰弹枪宏基因组学揭示了蜱传病原体的更广泛的多样性，包括立克次体和埃利希氏体，并通过在pcr阴性样本中检测低丰度病原体显示出更高的灵敏度。合并感染很常见，多变量统计分析发现环境变量（如湿度、一天中的时间、土地覆盖）与微生物多样性和预测的基因功能之间存在显著关联。值得注意的是，在下午早些时候和北部地点采集的蜱的多样性较高。共现网络分析显示立克次体是中心分类单元，与其他微生物有多个显著的正相关，而其他病原体基本不存在或处于外围。这些发现强调了宏基因组方法在病原体检测中的分辨率提高，以及分子监测与生态元数据相结合的价值。我们的研究为当地蜱虫微生物群和病原体流行提供了重要的见解，这可能为宾夕法尼亚州中部的公共卫生干预和媒介管理策略提供信息。

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引用次数: 0

Prevalence and risk factors of antimicrobial resistance in Staphylococcus spp. and Escherichia coli in fruit bats at high-risk human-wildlife interfaces in Bangladesh 孟加拉国高危人类与野生动物交界处果蝠中葡萄球菌和大肠杆菌的耐药性流行情况及危险因素

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-18 DOI: 10.1016/j.onehlt.2025.101300

Md Helal Uddin , Shariful Islam , Pronesh Dutta , Monjurul Islam , Md. Kaisar Rahman , Muhammad Sazzad Hossain , Md Shahjalal Sagor , Md. Aftabuddin Rumi , Meerjady Sabrina Flora , Jade K. Forwood , Mohammed Abdus Samad , Jonathan H. Epstein , Sharmin Chowdhury , Ariful Islam

Antimicrobial resistant (AMR) bacteria are frequently detected in wildlife and are often considered an indicator of anthropogenic pathogen exposure to wildlife. However, the role of bats in AMR dissemination remains poorly understood. We conducted a cross-sectional study to investigate the prevalence and risk factors associated with AMR patterns in Staphylococcus spp. and Escherichia coli isolated from frugivorous bats in Bangladesh. We collected 369 noninvasive fecal samples from Pteropus medius and Rousettus leschenaultii individual bats. Bacterial isolation was performed using selective media, biochemical tests and performed polymerase chain reaction (PCR) for confirmation of Staphylococcus spp. and E. coli. Antimicrobial susceptibility testing for antimicrobials was conducted using the Kirby-Bauer disc diffusion technique. The prevalence of E. coli and Staphylococcus spp. was 29.8 % and 28.5 % respectively. Overall, 28.2 % of E. coli and 26.3 % of Staphylococcus spp. exhibited resistance to at least one antimicrobial. Logistic regression analysis revealed that resistant Staphylococcus spp. colonisation was significantly higher in rural areas (OR = 2.6) and in R. leschenaultii species (OR = 2.6), while resistant E. coli was higher in urban areas (OR = 2.0) and in P. medius bat (OR = 1.7). Staphylococcus spp. showed the highest resistance to ampicillin (56 %), followed by clindamycin (23 %). On the other hand, E. coli showed the highest resistance against cefepime (16 %) followed by ampicillin (13 %). While the source of AMR bacteria in bats remains unclear, bat drinking habits on the contaminated water bodies with people and domestic animals might be source of resistant bacteria to bats. Future One Health research is recommended to understand the ecology of AMR and role of bats in the transmission of resistant bacteria across ecosystems.

抗微生物药物耐药性（AMR）细菌经常在野生动物中检测到，通常被认为是人类病原体暴露于野生动物的指标。然而，蝙蝠在抗菌素耐药性传播中的作用仍然知之甚少。我们进行了一项横断面研究，以调查从孟加拉国食果蝙蝠中分离的葡萄球菌和大肠杆菌中与AMR模式相关的流行率和危险因素。我们收集了369份中翼蝠和leschenaultii蝙蝠的非侵入性粪便样本。采用选择性培养基、生化试验和聚合酶链反应（PCR）进行细菌分离，以确定葡萄球菌和大肠杆菌。采用Kirby-Bauer圆盘扩散技术进行抗菌药物的药敏试验。大肠杆菌和葡萄球菌感染率分别为29.8%和28.5%。总体而言，28.2%的大肠杆菌和26.3%的葡萄球菌对至少一种抗菌素具有耐药性。Logistic回归分析显示，农村地区（OR = 2.6）和leschenauli种（OR = 2.6）的耐药葡萄球菌定植量显著高于城市地区（OR = 2.0）和P. medium bat （OR = 1.7）的耐药大肠杆菌定植量显著高于城市地区（OR = 2.0）。葡萄球菌对氨苄西林的耐药性最高（56%），其次是克林霉素（23%）。另一方面，大肠杆菌对头孢吡肟的耐药性最高（16%），其次是氨苄西林（13%）。虽然蝙蝠AMR细菌的来源尚不清楚，但蝙蝠与人和家畜一起在受污染的水体上饮水的习惯可能是蝙蝠耐药细菌的来源。建议未来的One Health研究以了解抗菌素耐药性的生态学以及蝙蝠在跨生态系统传播耐药细菌中的作用。

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引用次数: 0

Genomic epidemiology of Salmonella Typhimurium and its monophasic variants in Southern China: A spatiotemporal and source attribution analysis 华南鼠伤寒沙门菌及其单相变异的基因组流行病学：时空和来源归因分析

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-15 DOI: 10.1016/j.onehlt.2025.101299

Ningbo Liao , Shunxiong Lei , Chengwei Liu , Shengnan Tang , Silu Peng

Salmonella Typhimurium and its monophasic variants are major contributors to foodborne illnesses globally, with zoonotic transmission posing significant public health risks. In southern China, persistent salmonellosis cases linked to poultry and pork highlight the need for advanced genomic tools to trace contamination sources and understand transmission dynamics. This study integrates whole-genome sequencing (WGS) and spatiotemporal data to investigate the molecular epidemiology of Salmonella in Jiangxi Province, a region with high incidence of foodborne salmonellosis. Analysis of 206 Salmonella isolates (2015–2021) revealed dominant sequence types (ST34, ST19, ST155, and ST469) associated with human clinical cases and food sources. High-resolution single nucleotide polymorphism (SNP) phylogenetic analysis revealed well-supported, monophasic clades corresponding to the major sequence types. This analysis provided strong genomic evidence for zoonotic transmission, with human clinical isolates being genetically almost identical (≤5 SNPs) to isolates from poultry (ST34/ST19) and pork (ST155/ST469) sources. Clonal clusters of monophasic Typhimurium variants (77.9 % of ST34 isolates) exhibited widespread geographic distribution across 11 prefectures, and the high genetic similarity among isolates suggests potential cross-regional transmission through contaminated food supply chains. High antimicrobial resistance (AMR) rates were detected against ampicillin (68.0 %), tetracycline (61.0 %), and sulfamethoxazole-trimethoprim (54.0 %), with multidrug-resistant (MDR) strains (60.2 %) prevalent in clinical and food-derived isolates. ST34 exhibited the highest MDR prevalence (75.4 %), driven by the presence of Salmonella Genomic Island 1 (SGI1) in many isolates. The β-lactamase gene blaTEM-1 was most prevalent (60.7 %), followed by tet(A) (54.4 %), and sul2 (47.6 %). Point mutations in the quinolone resistance-determining region (QRDR), specifically in gyrA, were identified as the primary mechanism for ciprofloxacin resistance. Spatial clustering identified significant clusters in live poultry markets, slaughterhouses, and retail meat, emphasizing the role of foodborne zoonotic reservoirs. Findings advocate for strengthened One Health interventions, including enhanced AMR monitoring, targeted food safety regulations, and real-time WGS-based surveillance to mitigate zoonotic transmission risks in southern China.

鼠伤寒沙门氏菌及其单相变种是全球食源性疾病的主要来源，人畜共患传播构成重大公共卫生风险。在中国南方，与家禽和猪肉有关的沙门氏菌病病例持续存在，这突出表明需要先进的基因组工具来追踪污染源并了解传播动态。本研究结合全基因组测序（WGS）和时空数据，对食源性沙门氏菌病高发地区江西省沙门氏菌的分子流行病学进行研究。分析2015-2021年206株沙门氏菌分离株，发现与人类临床病例和食物来源相关的优势序列类型（ST34、ST19、ST155和ST469）。高分辨率单核苷酸多态性（SNP）系统发育分析显示了与主要序列类型相对应的良好支持的单相分支。该分析为人畜共患病传播提供了强有力的基因组证据，人类临床分离株与家禽（ST34/ST19）和猪肉（ST155/ST469）源分离株在遗传上几乎相同（≤5个snp）。单相鼠伤寒菌变异的克隆群（占ST34分离株的77.9%）在11个县具有广泛的地理分布，分离株之间的高度遗传相似性表明可能通过受污染的食品供应链进行跨区域传播。对氨苄西林（68.0%）、四环素（61.0%）和磺胺甲氧唑-甲氧苄啶（54.0%）的耐药率较高，临床和食源性分离株中普遍存在多重耐药菌株（60.2%）。由于在许多分离株中存在沙门氏菌基因组岛1 (SGI1)， ST34的耐多药患病率最高（75.4%）。β-内酰胺酶基因blatem1最为常见（60.7%），其次是tet(A)（54.4%）和sul2（47.6%）。喹诺酮类药物耐药决定区（QRDR）的点突变，特别是gyrA，被确定为环丙沙星耐药的主要机制。空间聚类确定了活禽市场、屠宰场和零售肉类中的显著聚集，强调了食源性人畜共患病宿主的作用。研究结果主张加强“同一个健康”干预措施，包括加强抗菌素耐药性监测、有针对性的食品安全法规和基于wgs的实时监测，以减轻中国南方人畜共患病传播风险。

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引用次数: 0

Genetic insights into hepatitis E virus through environmental surveillance in Europe 通过欧洲环境监测了解戊型肝炎病毒的基因

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-15 DOI: 10.1016/j.onehlt.2025.101302

Hao Wang , Marianela Patzi-Churqui , Linn Dahlsten Andius , Kristina Nyström , Martin Lagging

Zoonotic hepatitis E has been a growing public health concern in Europe, but the transmission of its causative agent, hepatitis E virus (HEV), remains incompletely understood. Environmental surveillance, particularly through wastewater monitoring, has proven valuable for tracking viral circulation and variant shift during the COVID-19 pandemic, yet its application to HEV is still limited. In this review, we systematically analyzed HEV sequences across Europe, focusing on environmental sources from a genetic perspective. Of more than 13,100 HEV sequences deposited in the NCBI database, only 2.4 % (316/13,118) originated from environmental samples, including wastewater, surface water, and biosolids. Additional typing data from the literature revealed highly uneven geographic distribution, with 97 % of environmental sequences reported from Italy, France, the United Kingdom (UK), Spain, Sweden, and Germany. HEV-3 was the dominant genotype, while HEV-1 and HEV-4 were occasionally detected. Subtypes 3c and 3f were most common, but their prevalence varied across countries and sample types. Some countries, such as France, Sweden, and the UK, exhibited divergent subtype patterns between humans, animals, and environmental sources, whereas others, such as Spain and Germany, showed more consistent distributions. These findings highlight the importance of integrating clinical, veterinary, and environmental surveillance to better understand HEV transmission in Europe under a One Health framework. However, the scarcity of environmental data, technical challenges in sequencing, and lack of standardized protocols limit comprehensive assessment of HEV circulation. Expanding sequencing efforts, improving detection methods, and coordinating international surveillance frameworks will be critical to strengthen HEV monitoring and preparedness against emerging HEV threats.

人畜共患戊型肝炎在欧洲已成为一个日益严重的公共卫生问题，但其病原体戊型肝炎病毒（HEV）的传播仍不完全清楚。环境监测，特别是通过废水监测，已被证明对跟踪COVID-19大流行期间的病毒循环和变异转移有价值，但其在HEV中的应用仍然有限。在这篇综述中，我们系统地分析了欧洲各地的HEV序列，重点从遗传角度分析了环境来源。在NCBI数据库中存储的13,100多个HEV序列中，只有2.4%（316/13,118）来自环境样本，包括废水、地表水和生物固体。来自文献的其他分型数据显示地理分布极不均匀，97%的环境序列来自意大利、法国、英国、西班牙、瑞典和德国。HEV-3为优势基因型，HEV-1和HEV-4偶见。亚型3c和3f最常见，但其患病率因国家和样本类型而异。一些国家，如法国、瑞典和英国，在人类、动物和环境来源之间表现出不同的亚型模式，而其他国家，如西班牙和德国，则表现出更一致的分布。这些发现强调了整合临床、兽医和环境监测以更好地了解同一健康框架下欧洲HEV传播的重要性。然而，缺乏环境数据、测序方面的技术挑战以及缺乏标准化方案限制了对HEV传播的全面评估。扩大测序工作、改进检测方法和协调国际监测框架对于加强HEV监测和防范新出现的HEV威胁至关重要。

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引用次数: 0

Collaboration under pressure: sustaining One Health research teams in a post-COVID environment 压力下的协作：在后covid环境中维持One Health研究团队

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-12 DOI: 10.1016/j.onehlt.2025.101298

Robin B. Gasser

The sustainability of contemporary One Health research increasingly relies on the capacity of universities, research institutes and partner organisations to support collaborative teams. Such teams are indispensable because they integrate diverse expertise, address complex problems and respond rapidly to health crises such as COVID-19. One Health provides a compelling exemplar of collaborative research, uniting human, animal and environmental health to tackle global challenges and emerging infectious diseases. Yet the resilience of such teams is being tested by neoliberal reforms that have reshaped higher education into a competitive marketplace and by managerial practices that prioritise measurable outputs over collegiality, autonomy and disciplinary breadth. The pandemic exposed the fragility of this model: laboratories closed, workloads intensified and financial pressures triggered redundancies, even as collaboration proved essential to global health responses. This Opinion article examines how systemic pressures and interpersonal dynamics intersect to influence the functioning of research teams in a post-COVID environment. It highlights funding precarity, employment insecurity, inequities and political instability as persistent challenges, and explores how performance pressures and competition can affect collaboration. Sustaining research teams requires institutional reforms, inclusive leadership, recognition of diverse contributions and alignment with global frameworks such as the United Nations Sustainable Development Goals (SDGs), so that One Health research and other multidisciplinary endeavours addressing emerging and neglected diseases remain resilient, impactful and socially relevant.

当代“一体健康”研究的可持续性越来越依赖于大学、研究机构和伙伴组织支持合作团队的能力。这样的团队不可或缺，因为他们整合了不同的专业知识，解决复杂的问题，并迅速应对COVID-19等卫生危机。“同一个健康”提供了一个令人信服的合作研究范例，将人类、动物和环境卫生结合起来，以应对全球挑战和新出现的传染病。然而，这些团队的韧性正受到新自由主义改革的考验，新自由主义改革将高等教育重塑为一个竞争激烈的市场，而管理实践则将可衡量的产出置于合作、自治和学科广度之上。这次大流行暴露了这一模式的脆弱性：实验室关闭，工作量增加，财政压力引发裁员，尽管事实证明合作对全球卫生应对至关重要。这篇意见文章探讨了系统压力和人际动态如何相互影响，影响后covid环境下研究团队的运作。它强调了资金不稳定、就业不安全、不平等和政治不稳定是持续的挑战，并探讨了绩效压力和竞争如何影响合作。维持研究团队需要机构改革、包容性领导、承认不同贡献并与联合国可持续发展目标（SDGs）等全球框架保持一致，以便“同一个健康”研究和其他多学科努力应对新出现的和被忽视的疾病，保持韧性、影响力和社会相关性。

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引用次数: 0

The effect of meteorological factors on severe fever with thrombocytopenia syndrome: Evidence from 34 Chinese cities 气象因素对发热伴血小板减少综合征的影响：来自中国34个城市的证据

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-11 DOI: 10.1016/j.onehlt.2025.101295

Guangju Mo , Xiyuan Huo , Meshack Kipkogei Biwott , Nan Chang , Haoqiang Ji , Lianfang Feng , Huaiping Zhu , Qiyong Liu

Background

Severe fever with thrombocytopenia syndrome (SFTS) is a climate-sensitive infectious disease, and its spatial distribution has been expanding in recent years. This study aimed to investigate the influence of meteorological factors on SFTS incidence.

Methods

Data on SFTS was extracted from the Infectious Disease Surveillance Report Management System from January 1, 2011 to December 31, 2023. A two-stage hierarchical analytical framework was employed in this study. First, a distributed lag nonlinear model was utilized to characterize the nonlinear exposure-response relationships between meteorological factors and the incidence of SFTS at the municipal level. Second, a multivariate meta-analysis was conducted to synthesize city-specific effect estimates, with explicit adjustment for inter-regional heterogeneity.

Results

From 2011 to 2023, 34 cities with cumulative cases ≥100 were included in the final analysis, which accounted for 94.59 % of the total SFTS cases during the same period in mainland China. The incidence risk of SFTS was positively correlated with temperature, relative humidity, precipitation, normalized difference vegetation index, and land cover, but negatively correlated with atmospheric pressure. The exposure-response relationship between average temperature and SFTS risk exhibited a single peak at 24.70 °C (RR = 2.78, 95 % CI: 1.14–6.79). Stratified analysis revealed the highest temperature-related risk in Eastern China at 27.50 °C (RR = 9.85, 95 % CI: 1.87–51.76), which was significantly elevated compared to central and northeastern regions. Regional variability was also observed for precipitation: the overall minimum risk occurred at 15.30 mm (RR = 0.49, 95 % CI: 0.24–0.98), whereas the risk nadir in Eastern China was at 16.02 mm monthly precipitation (RR = 0.29, 95 % CI: 0.10–0.80).

Conclusions

This study demonstrates that temperature and precipitation significantly influence SFTS incidence, with effects lagging consistently by 1–2 months. These findings can be integrated into China's Smart Multi-Point Surveillance System by incorporating region-specific meteorological thresholds to trigger early warnings. The system could then activate targeted interventions, such as tick control measures, accounting for the observed 1–2 month lag between climatic conditions and disease occurrence. Such climate-adaptive approaches would enhance the precision and timeliness of SFTS prevention and control efforts nationwide.

发热伴血小板减少综合征（SFTS）是一种气候敏感型传染病，近年来其空间分布范围不断扩大。本研究旨在探讨气象因素对SFTS发病的影响。方法从2011年1月1日至2023年12月31日传染病监测报告管理系统中提取SFTS病例数据。本研究采用两阶段层次分析框架。首先，利用分布滞后非线性模型表征了气象因子与城市SFTS发病率之间的非线性暴露响应关系。其次，通过多元荟萃分析综合城市效应，并对区域间异质性进行了明确调整。结果2011 - 2023年共纳入34个累计病例≥100例的城市，占同期中国大陆SFTS病例总数的94.59%。SFTS发病风险与气温、相对湿度、降水、归一化植被指数、土地覆被呈显著正相关，与气压呈显著负相关。平均温度与SFTS风险的暴露-响应关系在24.70℃时呈现单峰（RR = 2.78, 95% CI: 1.14 ~ 6.79）。分层分析显示，中国东部地区温度相关风险最高，为27.50°C (RR = 9.85, 95% CI: 1.87 ~ 51.76)，与中部和东北部地区相比显著升高。降水也存在区域差异：总体最小风险发生在15.30 mm (RR = 0.49, 95% CI: 0.24-0.98)，而中国东部的风险最低点发生在16.02 mm （RR = 0.29, 95% CI: 0.10-0.80）。结论温度和降水对SFTS发病率有显著影响，且滞后1 ~ 2个月。这些发现可以通过结合特定区域的气象阈值来触发预警，整合到中国的智能多点监测系统中。然后，该系统可以启动有针对性的干预措施，如蜱虫控制措施，以弥补观测到的气候条件与疾病发生之间1-2个月的滞后。这种适应气候变化的方法将提高全国SFTS防控工作的准确性和及时性。

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引用次数: 0

Hotspot or blind spot? Fine-scale spatial heterogeneity and methodological bias in Chlamydia psittaci prevalence rate reports from urban feral pigeons (Columba livia f. urbana) 热点还是盲区？城市野鸽（Columba livia . urbana）鹦鹉热衣原体患病率报告的精细尺度空间异质性和方法学偏差

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-10 DOI: 10.1016/j.onehlt.2025.101293

Valentin Adrian Kiss , Bram Vanden Broecke , Sofie De Bruyckere , An Martel , Wendt Müller

Urban wildlife populations often carry zoonotic pathogens that pose considerable public health risks through direct contact with humans. However, disease prevalence in urban settings is generally reported at the city level, which disregards spatial heterogeneity due to local differences in habitat structure or resource availability in the urban landscape. This study therefore examines the fine-scale spatial heterogeneity of Chlamydia psittaci, a generalist bacterium that frequently infects feral pigeons, in Antwerp, Belgium. We collected samples from 377 pigeons at 23 locations and performed qPCR screening for C. psittaci. At the same time, we performed an extensive literature review that includes 20 studies from 29 unique cities globally. Our findings indicate that the prevalence variance within Antwerp (CV = 0.70) is comparable to the variation reported among cities worldwide (CV = 0.88), suggesting that distinct locations within a single city can exhibit differences comparable to those between entirely different cities. Our data suggest that citywide or even countrywide are likely confounded by small scale spatial infection heterogeneity. A combination simulation showed that at least 12 unique sampling sites are necessary to accurately assess the true prevalence at the city level. Finally, we could show that also the screening method influences reported prevalence, with blood samples and non-PCR screening inflating reported prevalence rates. Taken together, we recommend that urban surveillance reports include at least 12 sampling sites, use standardized screening protocols and provide site-level data so that fine-scale heterogeneity can be taken into account.

城市野生动物种群往往携带人畜共患病原体，通过与人类直接接触构成相当大的公共卫生风险。然而，城市环境中的疾病流行情况一般是在城市一级报告的，这忽略了由于生境结构或城市景观资源可用性的地方差异而造成的空间异质性。因此，本研究考察了比利时安特卫普市鹦鹉热衣原体的精细尺度空间异质性。鹦鹉热衣原体是一种常见的细菌，经常感染野鸽。我们采集了23个地点377只鸽子的样本，并进行了鹦鹉螺的qPCR筛选。同时，我们进行了广泛的文献综述，其中包括来自全球29个独特城市的20项研究。我们的研究结果表明，安特卫普的患病率差异（CV = 0.70）与世界各地城市之间的差异（CV = 0.88）相当，这表明单个城市内不同地点的差异可以与完全不同的城市之间的差异相当。我们的数据表明，全市甚至全国范围内的小尺度空间感染异质性可能混淆。综合模拟结果表明，至少需要12个独特的采样点才能准确评估城市水平的真实患病率。最后，我们可以证明筛查方法也影响报告的患病率，血液样本和非pcr筛查夸大了报告的患病率。综上所述，我们建议城市监测报告至少包括12个采样点，使用标准化的筛选方案，并提供站点级别的数据，以便考虑到精细尺度的异质性。

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引用次数: 0