One Health最新文献

{"title":"Microbial biopesticides: A one health perspective on benefits and risks","authors":"Panqin Cai ,&nbsp;George Dimopoulos","doi":"10.1016/j.onehlt.2024.100962","DOIUrl":"10.1016/j.onehlt.2024.100962","url":null,"abstract":"<div><div>Controlling insect pests that destroy crop and spread diseases will become increasingly crucial for addressing the food demands of a growing global population and the expansion of vector-borne diseases. A key challenge is the development of a balanced approach for sustainable food production and disease control in 2050 and beyond. Microbial biopesticides, derived from bacteria, viruses, fungi, protozoa, or nematodes, offer potentially significant benefits for promoting One Health and contributing to several United Nations Sustainable Development Goals (SDGs). This narrative review examines the benefits and risks of microbial biopesticides from a One Health perspective, focusing on the Americas and Europe, and aligned with respective SDGs.</div><div>The value of biopesticides in sustainable agriculture and integrated pest management (IPM) approaches for food security, particularly SDG 2 (Zero Hunger) and SDG 1 (No Poverty) has been widely recognized, with relatively fewer adverse effects to people and the environment than synthetic pesticides. With increased demand and usage, microbial biopesticides can be expected to contribute further to additional SDGs such as SDG 12 (responsible consumption and production) through waste recycling for biopesticide production and remediation of polluted ecosystems, and by reducing vector-borne disease burdens such as malaria and dengue. Nevertheless, the prudent and judicious application of microbial biopesticides is crucial to ensuring their effectiveness and maximizing their One Health benefits while minimizing pest resistance and unintended impacts. From a One Health perspective, this goal involves incorporating microbial biopesticides into a comprehensive biological control strategy within an IPM framework for sustainable agriculture and for controlling vector-borne diseases.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100962"},"PeriodicalIF":4.1,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovering topics and trends in biosecurity law research: A machine learning approach","authors":"Yang Liu","doi":"10.1016/j.onehlt.2024.100964","DOIUrl":"10.1016/j.onehlt.2024.100964","url":null,"abstract":"<div><div>This study employed machine learning techniques, specifically Latent Dirichlet Allocation (LDA), to analyze 559 articles on biosecurity legislation from 1996 to 2023. The LDA model identified nine key research topics, including Agricultural Management and Production, Biosafety and Environmental Impact, Biological Invasion and Regulation, Biosecurity Legislation and Prevention, Agriculture and Environmental Relations, Virus Infection and Governance, Health Risk Assessment and Detection, Disease Prevention and Biotechnology, and Policy Control and Research. The findings reveal significant trends: an increasing focus on Biosecurity Legislation and Prevention and a declining interest in Agricultural Management and Production. Geographically, Australia, Canada, and the United States lead in biosecurity research, exhibiting diverse research topics. Journal-level analysis highlights central topics such as Agricultural Management and Production, Biosecurity Legislation and Prevention, and Health Risk Assessment and Detection. This study's use of LDA reduces subjective bias, providing a more objective analysis of global biosecurity legislation literature. The research underscores the importance of expanding geographical scope, integrating advanced machine learning models, adopting interdisciplinary approaches, and assessing policy impacts to enhance biosecurity strategies globally.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100964"},"PeriodicalIF":4.1,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effect of acute versus persistent insect-specific flavivirus infection on superinfection exclusion of West Nile, Zika and chikungunya viruses in RNAi-competent and -deficient mosquito cells","authors":"Wessel Willemsen ,&nbsp;Nick Helmes ,&nbsp;Gijs J. Overheul ,&nbsp;Marleen Henkens ,&nbsp;Ruben Spruijt ,&nbsp;Ronald P. van Rij ,&nbsp;Monique M. van Oers ,&nbsp;Gorben P. Pijlman ,&nbsp;Jelke J. Fros","doi":"10.1016/j.onehlt.2024.100960","DOIUrl":"10.1016/j.onehlt.2024.100960","url":null,"abstract":"<div><div>Millions of people are annually infected by mosquito-transmitted arboviruses including dengue virus (DENV), West Nile virus (WNV), Zika virus (ZIKV) and chikungunya virus (CHIKV). Insect-specific flaviviruses (ISFs), which only infect mosquitoes and cannot replicate in vertebrates, can offer a potential one health strategy to block the transmission of arboviruses by reducing the mosquito's susceptibility for subsequent arbovirus infections through superinfection exclusion (SIE). Most SIE studies focus on acute ISF infections in RNAi-deficient <em>Aedes albopictus</em> C6/36 cells. Because ISFs are known to persistently infect mosquitoes, acute infections in C6/36 cells may not accurately reflect natural interactions between ISFs and arboviruses. To study the underlying mechanisms for SIE, we persistently infected C6/36 and RNAi-competent <em>Aedes aegypti</em> Aag2 cells with the ISF Binjari virus (BinJV) and a BinJ-ZIKV chimera that contains the ZIKV prME structural genes. SIE of WNV, ZIKV and CHIKV by BinJV was more pronounced in acute than in persistently infected cells and much stronger in acutely infected C6/36 cells compared to Aag2 cells. The viability of RNAi-deficient mosquito cells was severely reduced upon acute ISF infection, which correlated to the observed SIE. However, persistently infected mosquito cells still inhibited subsequent arbovirus replication. Moreover, RNAi-competent Aag2 cells were better protected against ZIKV superinfection when they were pre-infected with BinJ-ZIKV as compared to BinJV. Therefore, acute ISF infections and strong cytopathic effects in RNAi-deficient cells augment SIE, while in persistently infected cells SIE is established through RNAi-dependent and independent mechanisms. This highlight the importance of using more representative <em>in vitro</em> models.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100960"},"PeriodicalIF":4.1,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Communication channel preference for raising rabies awareness among dog owners in Thailand: A nationwide study","authors":"Wagee Worrawattanatam ,&nbsp;Wongsaton Ektasaeng ,&nbsp;Phakwat Pornsuksant ,&nbsp;Sarin Suwanpakdee ,&nbsp;Sith Premashthira ,&nbsp;Anuwat Wiratsudakul","doi":"10.1016/j.onehlt.2024.100955","DOIUrl":"10.1016/j.onehlt.2024.100955","url":null,"abstract":"<div><div>Rabies is a severe zoonotic disease with potentially fatal consequences. Effective communication channels are crucial for disseminating key rabies prevention and control messages to target populations. This study examined how dog owners' demographic factors influenced communication channels in Thailand. We distributed a questionnaire survey to retrieve general demographic data of participants and the ranks of their communication channels. We used the mean ranking score to assess the most accessible and commonly used platforms. Univariate and multiple logistic regression methods were used to determine the association between each demographic feature and the preference for communication. In total, 476 participants were involved across all regions of Thailand. Village health volunteers represented the most selected channel, as identified by the mean ranking (3.32), followed by public loudspeaker (3.30) and television (2.93). Age, occupation, region, and cat ownership significantly influenced how people chose the channels. Moreover, farmers likely received information from various sources, and elderly individuals generally preferred to receive information about rabies from administrative authorities, such as village heads. These results can benefit policymakers aiming to enhance communication strategies in public health. This study enhances rabies risk communication and aligns with global health initiatives to eliminate dog-mediated rabies by 2030.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100955"},"PeriodicalIF":4.1,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bat predation by domestic cats: A neglected rabies-risk in Ecuador","authors":"Eduardo A. Díaz ,&nbsp;Carolina Sáenz ,&nbsp;Rebecca Zug","doi":"10.1016/j.onehlt.2024.100958","DOIUrl":"10.1016/j.onehlt.2024.100958","url":null,"abstract":"","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100958"},"PeriodicalIF":4.1,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A one health approach for integrated vector management monitoring and evaluation","authors":"Johanna Fite ,&nbsp;Thierry Baldet ,&nbsp;Antoinette Ludwig ,&nbsp;Sylvie Manguin ,&nbsp;Claude Saegerman ,&nbsp;Frédéric Simard ,&nbsp;Philippe Quénel","doi":"10.1016/j.onehlt.2024.100954","DOIUrl":"10.1016/j.onehlt.2024.100954","url":null,"abstract":"<div><div>The French Agency for Food, Environmental and Occupational Health &amp; Safety (Anses) has set up a multidisciplinary working group (WG) to develop an innovative One Health approach for the monitoring and evaluation of an integrated vector management system (IVMS) on a territorial scale. Four existing evaluation guidelines and methods have been combined into a semi-quantitative evaluation approach that takes into account all the dimensions of an integrated process. We propose a set of 34 criteria divided into three sections (objectives and management, implementation, integration) that correspond to the main functional components of an IVMS. Each criterion is assigned a score based on the results of a scoring questionnaire completed by the system's stakeholders, and two graphical outputs are generated using a specific combination of these scores. An overview of the system's performance is provided through a series of pie charts synthesizing the scores for each of the three sections and the corresponding eleven subsections. A radar chart further combines the results according to eight attributes chosen to characterize the qualities of the system. Our approach was tested for the invasive mosquito <em>Aedes albopictus,</em> a main vector of arboviruses, in two French territories with contrasting dengue epidemiology. This approach is intended to be generic and usable in all territories that are at risk of being affected by arboviruses, whether in tropical or temperate regions. Beyond a conventional assessment of the various components of an IVMS, our interdisciplinary and multisectoral approach aims to gain a better understanding of such a system in its environment, its overall functioning and its mechanisms for adapting to contextual change. It also aims to identify avenues for improvement as part of a continuous quality process, and to facilitate comparisons between territories and the cross-fertilization of knowledge between stakeholders.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100954"},"PeriodicalIF":4.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance of soil-transmitted helminths and other intestinal parasites in shelter dogs, Mississippi, USA","authors":"Huan Zhao ,&nbsp;Patsy A. Zendejas-Heredia ,&nbsp;Vito Colella ,&nbsp;Irene Arguello ,&nbsp;Kai Brookes ,&nbsp;Indu S. Panicker ,&nbsp;John M. Williams ,&nbsp;Kayla N. Patterson ,&nbsp;Gurbaksh Singh ,&nbsp;Charlotte V. Hobbs ,&nbsp;Richard S. Bradbury","doi":"10.1016/j.onehlt.2024.100956","DOIUrl":"10.1016/j.onehlt.2024.100956","url":null,"abstract":"<div><div>In recent years, soil-transmitted helminthiases, including strongyloidiasis have become a prominent public health concern in the southeastern United States of America (USA). While there is ongoing human soil-transmitted helminths (STH) surveillance in Mississippi and Alabama, very little attention has been paid to potentially zoonotic STH from dogs in this region. We microscopically examined faecal samples collected from 252 shelter dogs in Mississippi using the formalin-ethyl acetate sedimentation method. Extracted DNA were subjected to three multiplex real-time polymerase chain reaction (qPCR) assays targeting canine STH (canine hookworm species, <em>Strongyloides</em> spp.<em>, Toxocara</em> species and <em>Baylisascaris procyonis</em>). The combined prevalence of STH by microscopy and qPCRs in Mississippi dogs was 62.7 %, with hookworms at 50.0 % and <em>Toxocara</em> at 24.2 %. qPCR identified <em>Ancylostoma caninum</em> (44.4 %), <em>Toxocara canis</em> (22.2 %), <em>Strongyloides</em> spp. (1.2 %), and <em>Uncinaria stenocephala</em> (0.8 %). No other canine hookworm species, <em>Baylisascaris procyonis</em>, or <em>Toxocara cati</em> were detected by qPCR. Seven additional intestinal parasites were identified by microscopy, including <em>Trichuris vulpis</em> (13.5 %), <em>Physaloptera</em> sp. (6.4 %), <em>Cystoisospora</em> sp. (3.2 %), <em>Dipylidium caninum</em> (1.2 %). <em>Giardia duodenalis</em> (0.8 %), <em>Alaria</em> sp. (0.4 %), and <em>Macracanthorhynchus</em> sp. (0.4 %). These findings, combined with recent human cases in Mississippi, highlight the need for targeted public health messaging to promote regular anthelmintic treatment for dogs and their owners.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100956"},"PeriodicalIF":4.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential impact of climate change on medication access and quality deserves far more attention","authors":"Warren A. Kaplan ,&nbsp;Davidson H. Hamer ,&nbsp;Kayoko Shioda","doi":"10.1016/j.onehlt.2024.100957","DOIUrl":"10.1016/j.onehlt.2024.100957","url":null,"abstract":"<div><div>Notwithstanding the obvious interconnection between humans and the world that they share with non-human inhabitants, the impact of our changing climate on certain aspects of the public health ecosystem has been under-investigated. We briefly describe some of the possible climate-induced changes in the procurement, distribution, access and use of medications, including those for animals generally and livestock specifically. A fuller understanding of the effect of climate change on medicine supply, access, use and quality, including how these affect antimicrobial resistance, would contribute to the further development of the “One Health” and “One Health Systems” concepts. We suggest that this understanding is not yet available, even though the changing incidence of infectious diseases due to changing climate has been studied. There is a need for improved understanding of the impact of extremes of humidity and heat on medication quality and research into heat-stable medicines as well as strategies for the improving resilience of the pharmaceutical supply and distribution system in complex public health emergencies caused by aberrant weather patterns.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100957"},"PeriodicalIF":4.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The contribution of community transmission to the burden of hospital-associated pathogens: A systematic scoping review of epidemiological models","authors":"Gary Lin ,&nbsp;Suprena Poleon ,&nbsp;Alisa Hamilton ,&nbsp;Nalini Salvekar ,&nbsp;Manuel Jara ,&nbsp;Fardad Haghpanah ,&nbsp;Cristina Lanzas ,&nbsp;Ashley Hazel ,&nbsp;Seth Blumberg ,&nbsp;Suzanne Lenhart ,&nbsp;Alun L. Lloyd ,&nbsp;Anil Vullikanti ,&nbsp;Eili Klein ,&nbsp;For the CDC MInD Healthcare Network","doi":"10.1016/j.onehlt.2024.100951","DOIUrl":"10.1016/j.onehlt.2024.100951","url":null,"abstract":"<div><div>Healthcare-associated infections (HAI), particularly those involving multi-drug resistant organisms (MDRO), pose a significant public health threat. Understanding the transmission of these pathogens in short-term acute care hospitals (STACH) is crucial for effective control. Mathematical and computational models play a key role in studying transmission but often overlook the influence of long-term care facilities (LTCFs) and the broader community on transmission. In a systematic scoping review of 4,733 unique studies from 2016 to 2022, we explored the modeling landscape of the hospital-community interface in HAI-causing pathogen transmission. Among the 29 eligible studies, 28 % (<em>n = 8</em>) exclusively modeled LTCFs, 45 % (<em>n = 13</em>) focused on non-healthcare-related community settings, and 31 % (<em>n = 9</em>) considered both settings. Studies emphasizing screening and contact precautions were more likely to include LTCFs but tended to neglect the wider community. This review emphasizes the crucial need for comprehensive modeling that incorporates the community's impact on both clinical and public health outcomes.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100951"},"PeriodicalIF":4.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of community action on animal vaccination uptake, antimicrobial usage, and farmers’ wellbeing in Ghana: study protocol for a cluster-randomized controlled trial","authors":"Francis Sena Nuvey ,&nbsp;Günther Fink ,&nbsp;Jan Hattendorf ,&nbsp;Daniel T. Haydon ,&nbsp;Gilbert Fokou ,&nbsp;Kennedy Kwasi Addo ,&nbsp;Jakob Zinsstag ,&nbsp;Clemence Esse-Dibby ,&nbsp;Bassirou Bonfoh","doi":"10.1016/j.onehlt.2024.100952","DOIUrl":"10.1016/j.onehlt.2024.100952","url":null,"abstract":"<div><div>Infectious animal diseases represent a major constraint to livestock productivity, food security and wellbeing in many developing countries. To mitigate these impacts, farmers frequently use antimicrobials without professional advice, potentially yielding drug residues in livestock products and the food chain, as well as resistant antimicrobial genes. Recent studies identified Contagious Bovine Pleuropneumonia (CBPP) and Peste des Petits Ruminants (PPR) as the diseases most negatively affecting ruminant livestock productivity and farmers’ wellbeing in Ghana. Despite the approval and availability of effective CBPP and PPR vaccines in Ghana, acceptability, affordability, accessibility, and availability of vaccination limit their uptake, with only 15% of farmers regularly vaccinating their herds. During formative qualitative research to identify barriers and potential intervention options, farmers suggested that establishing localized farmer intervention platforms could improve vaccine access. The main idea is the platforms enabling information exchange on livestock vaccines, enhancing service scheduling, and sharing vaccination costs among farmers living in the same locality. We now wish to test formally this hypothesis.</div><div>Through a cluster-randomized controlled trial, we aim to determine the effect of localized farmer platforms on animal vaccination uptake (primary outcome), antimicrobials use in livestock production, disease-induced mortality in livestock, and livestock farmers’ wellbeing (secondary outcomes). The intervention will be randomized at the community level. The study will involve 460 farming households across 46 rural communities (study clusters). Clusters will be randomized with equal probability to treatment and control (23 communities each). Approximately 10 households per community will be sampled for data collection at baseline, and at 6 and 12 months post-intervention, following prevailing vaccination schedules. We will conduct an intention-to-treat analysis using the available case population. The findings will inform strategies to tackle the impact of infectious livestock diseases on food security, public health and farmers’ wellbeing.</div><div><strong>Trial registry</strong>: <span><span>https://pactr.samrc.ac.za/;</span><svg><path></path></svg></span> ID No.: PACTR202405854213937.</div></div>","PeriodicalId":19577,"journal":{"name":"One Health","volume":"20 ","pages":"Article 100952"},"PeriodicalIF":4.1,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}