One Health最新文献_第9页

Country-wide assessment of tick-borne pathogens collected in ticks between 2021 and 2024 in Germany, with a focus on Francisella: A one health pilot study 2021年至2024年间在德国蜱虫中收集的蜱传病原体的全国评估，重点是Francisella：一项健康试点研究

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-01 Epub Date: 2025-09-05 DOI: 10.1016/j.onehlt.2025.101190

Kristin Köppen , Natalia Marta Zmarlak-Feher , Achim Dörre , Peter Hagedorn , Claudia Kohl , Klaus Heuner

Ticks are important vectors for several pathogens, among which Francisella tularensis subsp. holarctica is the most relevant tularaemia-causing subspecies in Europe. The number of human tularaemia cases in Germany has increased in recent years, and ticks play an important role in disease transmission. The aim of this study was to perform a pilot study addressing the presence of tick-borne pathogens in ticks across Germany, with a special focus on Francisella.

A total of 339 Dermacentor reticulatus ticks and 353 Ixodes ricinus ticks were collected in Germany between 2021 and 2024. DNA was extracted and analysed individually by multiplex qPCR assays detecting F. tularensis subsp. holarctica, Francisella-like endosymbionts, Rickettsia spp., Borrelia burgdorferi sensu lato complex, B. miyamotoi, Anaplasma phagocytophilum, Ehrlichia spp., Coxiella burnetii, Bartonella spp., Babesia spp., and tick-borne encephalitis virus.

PCR testing revealed a varying frequency of these pathogens depending on the tick species. The most frequently identified bacteria were Francisella-like endosymbionts (18–97 %), Rickettsia spp. (32–74 %), and B. burgdorferi (0–16 %). The occurrence of F. tularensis subsp. holarctica, B. miyamotoi, A. phagocytophilum, Babesia spp., and tick-borne encephalitis virus was observed at a low frequency in ticks (less than 10 % in either tick species). Coxiella burnetii, Ehrlichia spp., and Bartonella spp. were not detected in the investigated ticks. More than 70 % of D. reticulatus ticks and 19 % of I. ricinus ticks were positive for at least two pathogens. There was a significant co-occurrence of Francisella-like endosymbionts and Rickettsia spp. in both tick species. This pilot study offers a framework for the surveillance of common, rare, and newly emerging tick-borne pathogens in Germany.

蜱是几种病原体的重要传播媒介，其中土拉弗朗西斯菌亚种。holarctica是欧洲最相关的引起土拉病的亚种。近年来，德国的人间土拉菌病病例有所增加，而蜱虫在疾病传播中起着重要作用。本研究的目的是进行一项试点研究，解决德国蜱虫中蜱传病原体的存在，特别关注弗朗西斯菌。2021年至2024年，在德国共收集到网纹革蜱339只，蓖麻蜱353只。提取DNA，分别用多重qPCR检测土拉菌亚种。holarctica， Francisella-like内共生菌，立克次体，伯氏疏螺旋体，宫氏疏螺旋体，嗜吞噬细胞无形体，埃利希氏体，伯氏柯谢氏体，巴尔通体，巴贝斯虫和蜱传脑炎病毒。聚合酶链反应检测显示，这些病原体的出现频率因蜱虫种类而异。最常见的细菌是Francisella-like内共生菌（18 - 97%）、立克次体（32 - 74%）和伯氏疏螺旋体（0 - 16%）。土拉菌亚种的发生。在蜱中观察到低频率的全北极蜱、宫氏蜱、嗜吞噬细胞伊蚊、巴贝斯虫和蜱传脑炎病毒（两种蜱均不到10%）。调查蜱中未检出伯纳氏柯谢氏体、埃利希体和巴尔通体。70%以上的网纹蜱和19%的蓖麻蜱至少对两种病原菌呈阳性。两种蜱体中均存在francisella样内共生菌和立克次体。这项试点研究为德国常见、罕见和新出现的蜱传病原体的监测提供了框架。

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引用次数: 0

Poultry-associated nitrofurantoin-resistant and pre-resistant Escherichia coli clones are found in multiple countries and one-health compartments 在多个国家和一个卫生部门发现了与家禽相关的耐硝基呋喃妥因和预耐药大肠杆菌克隆

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-01 Epub Date: 2025-10-13 DOI: 10.1016/j.onehlt.2025.101241

Jordan E. Sealey, Beth Astley, Oliver Mounsey, Matthew B. Avison

Escherichia coli is the most common cause of urinary tract infection (UTI) in humans. The nitrofuran-class antibacterial drug nitrofurantoin is a frequent UTI therapy, with resistance rarely observed. Here we show that nitrofurantoin resistant (NFT-R) E. coli are sometimes excreted by dogs fed a raw meat diet in the city of Bristol, United Kingdom, and that NFT-R and pre-resistant (one mutation away from NFT-R) E. coli can be found contaminating chicken meat sold for human consumption and chicken-based raw dog food in the same city. Using whole genome sequencing, we identified multiple NFT-R or pre-resistant E. coli clones spanning several phylogroups. These clones were dominated by isolates from poultry farms and poultry meat in Europe, Canada, the United States and Japan, and we identified instances where closely related NFT-R and pre-resistant isolates have colonised humans and caused UTIs. The origins of these poultry-associated NFT-R and pre-resistant E. coli clones are uncertain, but nitrofuran-class antibacterials (particularly furazolidone, furaltadone, and nitrofurazone) were used in poultry production during the 1970s and 80s, though this practice has been banned since the 1990s. It is possible, therefore, that this caused an initial selective pressure for the emergence of NFT-R and pre-resistant E. coli clones on poultry farms. Our findings have potentially important implications for domestic hygiene, particularly among people receiving nitrofurantoin therapy.

大肠杆菌是人类尿路感染（UTI）最常见的原因。硝基呋喃类抗菌药物呋喃妥因是常用的尿路感染治疗药物，很少出现耐药性。在英国布里斯托尔市，我们发现耐硝基呋喃万因（NFT-R）大肠杆菌有时会被喂食生肉的狗排出体外，而且在同一城市，可以发现NFT-R和预耐药（与NFT-R有一个突变）大肠杆菌污染了供人类食用的鸡肉和以鸡肉为原料的生狗粮。使用全基因组测序，我们鉴定了多个NFT-R或预抗性大肠杆菌克隆，跨越多个系统群。这些克隆主要是来自欧洲、加拿大、美国和日本的家禽养殖场和禽肉的分离株，我们确定了密切相关的NFT-R和预耐药分离株定殖于人类并引起尿路感染的情况。这些与家禽相关的NFT-R和预耐药大肠杆菌克隆的来源尚不确定，但硝基呋喃类抗菌药物（特别是呋喃唑酮、呋喃他酮和硝基呋喃酮）在20世纪70年代和80年代用于家禽生产，尽管这种做法自20世纪90年代以来已被禁止。因此，这可能造成了NFT-R和预耐药大肠杆菌克隆在家禽养殖场出现的最初选择压力。我们的发现对家庭卫生具有潜在的重要意义，特别是在接受呋喃妥因治疗的人群中。

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引用次数: 0

Camera trap assessment of bushpig (Potamochoerus larvatus)-domestic animal interactions and implications for pathogen transmission in rural habitats of Madagascar 摄像机诱捕法评估马达加斯加农村地区丛林猪（小狐尾鼠）与家畜相互作用及其对病原体传播的影响

IF 4.1 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-01 Epub Date: 2025-07-19 DOI: 10.1016/j.onehlt.2025.101149

Rianja Rakotoarivony , Ariane Payne , Daouda Kassie , Steven M. Goodman , Alpha Andriamahefa , Modestine Raliniaina , Raphaël Rakotozandrindrainy , Ferran Jori

In some rural areas of Madagascar, bushpigs (Potamochoerus larvatus) are reported to be attracted to human disturbed habitats and share the same environment with domestic animals, including pigs (Sus scrofa). Such cohabitation can facilitate the transmission of pathogens between bushpigs and other domestic animals. To assess bushpig-domestic animal interactions and their implications for pathogen transmission, 26 camera-traps were deployed for three months around 10 villages in two separate regions of western Madagascar. The camera-traps were positioned at animal attraction sites: trophic resources, resting areas, and water points, and captured 17,804 images. No direct interactions (simultaneous presence) between bushpigs and domestic species were observed after analysis of 2678 trap nights. However, 44 indirect interactions (non-simultaneous presence) were recorded. The median critical time window (CTW), calculated as the time interval between the consecutive presence of bushpigs and some domestic species, was 646 min [34–1412 min]) for pigs, 672 min for cats [range 44–886 min], and 690 min for cattle [range 584–765 min]. Such CTW estimates are shorter than the average survival rate of several infectious pathogens potentially present in the environment, including African swine fever virus, Mycobacterium bovis, and Toxoplasma gondii. Factors such as proximity to water sources and protected areas statistically increased the chances of these interactions. Our research provided novel information on the level of interaction between bushpigs and other domestic animals in anthropized rural areas and which can be used to design and implement strategies to mitigate the risk of pathogen spread at the wildlife/livestock/human interface.

据报道，在马达加斯加的一些农村地区，丛林猪（野狐属幼虫）被人类干扰的栖息地所吸引，并与包括猪在内的家畜共享同一环境。这种同居可以促进病原体在丛林猪和其他家畜之间的传播。为了评估丛林猪与家畜的相互作用及其对病原体传播的影响，在马达加斯加西部两个不同地区的10个村庄周围部署了26个相机陷阱，为期3个月。摄像机陷阱设置在动物吸引点：营养资源、休息区和水源点，共拍摄了17,804张图像。在2678个陷阱夜的分析中，未观察到丛林猪与家养物种之间的直接相互作用（同时存在）。然而，记录了44次间接相互作用（非同时存在）。中位临界时间窗（CTW），即连续出现丛林猪和一些家猪之间的时间间隔，猪为646分钟（34-1412分钟），猫为672分钟（44-886分钟），牛为690分钟（584-765分钟）。这样的CTW估计值低于环境中可能存在的几种传染性病原体的平均存活率，包括非洲猪瘟病毒、牛分枝杆菌和刚地弓形虫。据统计，靠近水源和保护区等因素增加了这些相互作用的机会。我们的研究提供了关于人源化农村地区丛林猪与其他家畜相互作用水平的新信息，可用于设计和实施减轻病原体在野生动物/牲畜/人类界面传播风险的策略。

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引用次数: 0

Changes in biodiversity drive trypanosome infections of wildlife in Panama 生物多样性的变化导致巴拿马野生动物的锥虫感染

IF 4.1 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-01 Epub Date: 2025-06-18 DOI: 10.1016/j.onehlt.2025.101113

Magdalena Meyer, Georg Eibner , Alexander Christoph Heni, Kerstin Wilhelm, Simone Sommer

Understanding how anthropogenic disturbances impact biodiversity and zoonotic disease transmission is critical for safeguarding human and animal health. In Panama, we studied the effects of these disturbances on wildlife populations and Trypanosoma cruzi infections, which cause Chagas disease in humans, at 23 different sites ranging from pristine forests to heavily altered monocultures. Our results indicate that human disturbance leads to increased trypanosome infection rates, primarily through two mechanisms: the proliferation of generalist marsupial host species, specifically Didelphis marsupialis and Philander opossum, which are key reservoirs for Trypanosoma cruzi, and a decline in the genetic diversity of the alternative rodent host Proechimys semispinosus. While species diversity did not affect infection probability in protected habitats, where natural processes support ecological resilience, higher diversity in disturbed, unprotected habitats was linked to a reduced risk of infection. These findings highlight the consequences of human impacts on wildlife diversity, including species assemblages and genetic diversity, and their potential role in disease ecology. We emphasize that conservation of pristine ecosystems and natural species communities is essential for mitigating zoonotic disease risks and preserving ecosystem health.

了解人为干扰如何影响生物多样性和人畜共患疾病传播，对于保护人类和动物健康至关重要。在巴拿马，我们研究了这些干扰对野生动物种群和导致人类恰加斯病的克氏锥虫感染的影响，在23个不同的地点，从原始森林到严重改变的单一栽培。结果表明，人为干扰导致锥虫感染率上升，主要通过两种机制：一是克氏锥虫主要寄主Didelphis marsupialis和Philander负鼠的增殖，二是替代寄主Proechimys semispinosus的遗传多样性下降。在自然过程支持生态恢复力的受保护生境中，物种多样性不影响感染概率，但在受干扰、未受保护的生境中，物种多样性较高与感染风险降低有关。这些发现突出了人类对野生动物多样性的影响，包括物种组合和遗传多样性，以及它们在疾病生态学中的潜在作用。我们强调，保护原始生态系统和自然物种群落对于减轻人畜共患疾病风险和维护生态系统健康至关重要。

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引用次数: 0

Poultry farms as reservoirs of azole-resistant fungi: Occupational health risks in agricultural facilities 作为抗唑真菌宿主的家禽养殖场：农业设施中的职业健康风险

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-01 Epub Date: 2025-10-06 DOI: 10.1016/j.onehlt.2025.101230

Bianca Gomes , Marta Dias , Renata Cervantes , Pedro Pena , Elisabete Carolino , Liliana Aranha Caetano , Susana Viegas , Carla Viegas

The intensification of poultry farming has raises concerns regarding microbial contamination and antifungal resistance, particularly involving Aspergillus fumigatus, a key pathogen presenting clinical relevance. This study aims to present the first in-depth evaluation of environmental conditions, airborne particles, microbial contamination, and fungal resistance to azole drugs in poultry farm environments. A multi-approach sampling strategy (passive and active sampling methods) was conducted throughout the poultry production cycle. Microbial characterization was performed, combining culture-dependent methods and molecular techniques with a focus on fungal diversity and azole resistance. Bacteria and fungal loads indoors exceed the outdoor levels in 80.85 % (n = 38/47) and 78.72 % (n = 37/47) of air samples, respectively. Toxigenic fungal species (Aspergillus spp. and Penicilium spp.) were widespread (air, swabs, electrostatic dust cloths,feed, bed). Fungi resistant to at least one antifungal (itraconazole, voriconazole, posaconazole) was found in 53.3 % of the total samples collected inside poultry pavilions (n = 45/126), including potentially azole-resistant Aspergillus species. Particulate matter acts as a carrier of microorganisms, enhancing workers respiratory exposure risks. Electrostatic dust cloths proved to be a valuable sampling method for exposure assessment to potential pathogenic and resistant fungi. Our findings identify poultry farms as potential hotspots for toxigenic and azole-resistant fungi with implications for occupational health. These results highlight the urgent need for targeted biosafety strategies to mitigate not only microbial contamination on the workplace, but also the spread of antifungal-resistant fungi in poultry facilities and surroundings

家禽养殖的加剧引起了对微生物污染和抗真菌耐药性的关注，特别是涉及烟曲霉，这是一种具有临床相关性的关键病原体。本研究旨在首次深入评估家禽养殖场环境条件、空气颗粒、微生物污染和真菌对唑类药物的耐药性。在整个家禽生产周期内采用了多方法抽样策略（被动和主动抽样方法）。结合培养依赖方法和分子技术进行微生物鉴定，重点研究真菌多样性和唑抗性。室内空气样品的细菌和真菌负荷分别超过室外80.85 % （n = 38/47）和78.72 % （n = 37/47）。产毒真菌种类（曲霉属和青霉属）广泛分布于空气、拭子、静电尘布、饲料、床上。在家禽馆舍内采集的样品中，发现对至少一种抗真菌药（伊曲康唑、伏立康唑、泊沙康唑）耐药的真菌占53.3% % (n = 45/126)，其中包括可能耐药的曲霉种。颗粒物是微生物的载体，增加了工人呼吸接触的风险。事实证明，静电防尘布是评估潜在致病性和抗性真菌暴露的一种有价值的采样方法。我们的研究结果表明，家禽养殖场是产生毒素和抗唑真菌的潜在热点，对职业健康有影响。这些结果表明，迫切需要有针对性的生物安全策略，不仅要减少工作场所的微生物污染，还要减少抗真菌真菌在家禽设施和环境中的传播

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引用次数: 0

Seroepidemiological surveillance of neutralizing antibodies against dengue virus serotypes among healthy adults in Bangkok, Thailand 泰国曼谷健康成人登革热病毒血清型中和抗体的血清流行病学监测

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-01 Epub Date: 2025-09-15 DOI: 10.1016/j.onehlt.2025.101202

Jakkraphong Nindee , Peeraya Ekchariyawat , Nichamon Pingkul , Wanwimon Thananate , Kedsara Panyasu , Thawisup Bunyamali , Pichayapa Penwichit , Chunya Puttikhunt , Sutha Sangiambut , Jiraphan Junjhon

Bangkok is a hyper-endemic urban area for dengue virus (DENV), where ongoing transmission poses a significant public health risk. Comprehensively understanding the interplay between human immunity, vector ecology, and environmental determinants is essential for developing effective, sustainable dengue control strategies. Population-level immunity provides insights into prior dengue exposure, and the presence of neutralizing antibody may reflect protection against infection. While most previous studies have focused on children, serological data on adults, who constitute the majority of those with continuous exposure, remain limited. This study aimed to characterize neutralizing antibody responses to all four DENV serotypes among healthy adults residing in Bangkok. Residual serum samples from 198 healthy adults collected in 2022 were analyzed, with equal distribution of males and females across five age groups. Neutralizing antibody responses against parental DENV-1 to DENV-4 were assessed using the focus reduction neutralization test (FRNT), with seropositivity defined as an FRNT₉₀ titer ≥10 to ensure assay specificity. Overall, 77.3 %; 95 % CI: 70.9–82.6 of individuals were seropositive for at least one DENV serotype. The lowest seroprevalence rate (54.2 %; 95 % CI: 40.3–67.4) was observed in the youngest (21–30 years) age group. Higher neutralizing antibody titers (FRNT₉₀ 100–1000) were more frequently detected against DENV-1 (51/114, 44.7 %; 95 % CI: 35.9–53.9), and DENV-2 (50/125, 40 %; 95 % CI: 31.8–48.8). These findings indicate age-related differences in DENV seropositivity and suggest recent or ongoing circulation of DENV-1 and DENV-2. The results underscore the importance of continued serotype-specific surveillance and support the implementation of an integrated One Health approach to dengue prevention in endemic urban settings.

曼谷是登革热病毒高流行城市地区，持续传播构成重大公共卫生风险。全面了解人类免疫、媒介生态学和环境决定因素之间的相互作用对于制定有效、可持续的登革热控制战略至关重要。人群免疫水平提供了对先前登革热暴露的见解，中和抗体的存在可能反映了对感染的保护。虽然以前的大多数研究都集中在儿童身上，但成人的血清学数据仍然有限，成人占持续接触者的大多数。本研究旨在表征居住在曼谷的健康成人对所有四种DENV血清型的中和抗体反应。分析了2022年收集的198名健康成年人的残留血清样本，在5个年龄组中男女分布均匀。使用焦点减少中和试验（FRNT）评估针对亲代DENV-1对DENV-4的中和抗体反应，血清阳性定义为FRNT90滴度≥10，以确保检测特异性。总体为77.3%；95% CI: 70.9-82.6的个体至少有一种DENV血清型呈血清阳性。最低的血清患病率（54.2%;95% CI: 40.3-67.4）出现在最年轻（21-30岁）年龄组。较高的中和抗体滴度（FRNT90 100-1000）在DENV-1 （51/114, 44.7%; 95% CI: 35.9-53.9）和DENV-2 （50/125, 40%; 95% CI: 31.8-48.8）中检测到的频率更高。这些发现表明DENV血清阳性的年龄相关差异，并提示最近或正在流行DENV-1和DENV-2。研究结果强调了持续进行血清型特异性监测的重要性，并支持在城市流行环境中实施“同一个健康”综合方法预防登革热。

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引用次数: 0

One health, one earth, one life: The overlooked role of veterinarians in the fight against COVID-19 and other public health emergencies in Italy 同一个健康，同一个地球，同一个生命：兽医在意大利抗击COVID-19和其他突发公共卫生事件中被忽视的作用

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-01 Epub Date: 2025-09-18 DOI: 10.1016/j.onehlt.2025.101207

Sante Roperto , Giovanni Di Guardo

This essay explores the crucial and often overlooked role of veterinarians in managing and responding to pandemics. Despite their pivotal activities in protecting public health, veterinarians in Italy were largely absent from the media storytelling of the COVID19 pandemic, which was mostly focused on a hospital-centered perspective. Regretfully, we witness herein the occurrence of a similar situation within the media coverage in Italy of other public health emergencies, such as those caused by the highly pathogenic avian influenza A(H5N1) virus and by the West Nile virus. This article examines the asymmetry in professional representation during public health crises in Italy, thereby calling for a more inclusive approach to global health challenges, employing a One Health framework that acknowledges the connection between human, animal and environmental health. Within this framework, we also report how veterinarians contribute to food safety, zoonotic disease monitoring, epidemiological studies and ecosystem management, all of which are essential for pandemic prevention and response. Our goal in bringing these issues to light is to increase public awareness on the crucial role of veterinarians in public health risk analysis, communication and policy formulation, which will ultimately make society more resilient to potential pandemic threats in the future.

本文探讨了兽医在管理和应对流行病方面的关键作用，但往往被忽视。尽管意大利兽医在保护公众健康方面发挥了关键作用，但他们在媒体对covid - 19大流行的报道中基本缺席，这些报道主要集中在以医院为中心的角度。遗憾的是，我们在此看到意大利媒体在报道其他突发公共卫生事件时也出现了类似的情况，例如由高致病性甲型H5N1禽流感病毒和西尼罗河病毒引起的突发公共卫生事件。本文考察了意大利公共卫生危机期间专业代表的不对称，从而呼吁采取更具包容性的方法应对全球卫生挑战，采用承认人类、动物和环境健康之间联系的“同一个健康”框架。在这一框架内，我们还报告了兽医如何为食品安全、人畜共患疾病监测、流行病学研究和生态系统管理做出贡献，所有这些对大流行的预防和应对都至关重要。我们曝光这些问题的目的是提高公众对兽医在公共卫生风险分析、沟通和政策制定方面的关键作用的认识，这最终将使社会更有能力应对未来潜在的大流行威胁。

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引用次数: 0

Situational analysis of antimicrobial resistance policies and program implementation in the Philippines, 2019–2023 2019-2023年菲律宾抗微生物药物耐药性政策和规划实施情况分析

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-01 Epub Date: 2025-10-30 DOI: 10.1016/j.onehlt.2025.101255

Sary Valenzuela , Percival Ethan Lao , Geminn Louis C. Apostol , Lea Elora A. Conda , Lystra Zyrill A. Dayapera , Anna Beatrice Enriquez , Elaine Joyce Diaz , Natasha Alexis Marie G. Jacinto , Luh Rai Maduretno Asvinigita

Antimicrobial Resistance (AMR) is a pressing global threat to public, agricultural, and environmental health. In 2015, the WHO launched the Global Action Plan on Antimicrobial Resistance (AMR), emphasizing the importance of a unified One Health approach to involve all sectors in combating AMR. Member states, including the Philippines, were encouraged to develop their own national action plans. This study is an implementation review of its second iteration, the Philippine National Action Plan to Combat AMR 2019–2023 using the One Health Approach, investigating its progress, successes, and challenges. Quantitative data was collected by asking relevant government agencies to rate each activity by its level of progress; results were elucidated and validated with national policies and reports, international benchmarks, insights from key informant interviews, and technical consultations with government agencies and international organizations. Findings revealed notable progress in AMR policy development, regulation, and surveillance in the human and animal health sectors. However, the environmental sector lacks formal engagement, regulatory mandates, and surveillance capacity, limiting a true One Health approach. Other challenges remain in agricultural data collection, laboratory capacity, and interagency coordination at the local levels, where implementation is crucial. Local authorities lack in training, support, and technical expertise on AMR's far-reaching impacts, hindering effective enforcement and response. Recommendations include increased laboratory and staff financing, expanded surveillance infrastructure, and enhanced environmental sector participation. Additionally, integrating socioeconomic and gender considerations into AMR strategies will improve policy responsiveness. While significant milestones have been achieved, sustained commitment, cross-sector collaboration, and strengthened regulatory frameworks are critical to ensuring a more comprehensive and effective response to AMR in the Philippines. This study was funded by the European Union and the Food and Agriculture Organization of the United Nations.

抗菌素耐药性（AMR）是对公众、农业和环境健康的紧迫全球威胁。2015年，世卫组织启动了《抗微生物药物耐药性全球行动计划》，强调必须采取统一的“一个健康”方针，让所有部门参与抗击抗微生物药物耐药性。会议鼓励包括菲律宾在内的会员国制定自己的国家行动计划。本研究是对《菲律宾2019-2023年抗抗生素耐药性国家行动计划》第二次实施情况的审查，调查其进展、成功和挑战。定量数据的收集方式是要求相关政府机构对每项活动的进展程度进行评级；结果通过国家政策和报告、国际基准、主要举报人访谈的见解以及与政府机构和国际组织的技术磋商得到阐明和验证。调查结果显示，人类和动物卫生部门在抗生素耐药性政策制定、监管和监测方面取得了显著进展。然而，环境部门缺乏正式参与、监管授权和监督能力，限制了真正的“同一个健康”方针。其他挑战仍然存在于农业数据收集、实验室能力和地方一级的机构间协调方面，这些方面的实施至关重要。地方当局在抗生素耐药性的深远影响方面缺乏培训、支持和技术专长，阻碍了有效的执法和应对。建议包括增加实验室和工作人员的资金，扩大监测基础设施，以及加强环境部门的参与。此外，将社会经济和性别因素纳入抗菌素耐药性战略将改善政策响应能力。虽然取得了重大里程碑，但持续承诺、跨部门合作和加强监管框架对于确保菲律宾更全面、更有效地应对抗生素耐药性至关重要。这项研究是由欧盟和联合国粮食及农业组织资助的。

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引用次数: 0

Knowledge, attitudes and risk practices on echinococcosis in Aysén District, Chile 智利ayssamin地区关于棘球蚴病的知识、态度和风险做法

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-01 Epub Date: 2025-07-30 DOI: 10.1016/j.onehlt.2025.101155

Nicole Sepulveda , Marcela Fresno , Yanina Poblete , Hernan Cañon Jones

Echinococcosis, a zoonotic disease caused by Echinococcus granulosus and E. multilocularis, presents significant health and economic challenges globally. This study assessed knowledge, attitudes, and practices regarding cystic echinococcosis in the rural communities, health professionals, and educators of Capitán Prat Province, Aysén Region, Chile. A survey of 243 participants revealed a high general awareness of the disease (81.6 %), with significant variations in knowledge levels and practices across sectors. Risk behaviours, such as allowing dogs to roam freely and improper disposal of animal viscera, were prevalent, particularly in rural areas. While preventive measures, including deworming and education, were highly valued, gaps in their consistent application persisted. The findings underscore the need for targeted educational campaigns and culturally sensitive interventions to address behavioural risk factors. Strengthening One Health initiatives through community engagement and intersectoral collaboration is critical to reducing the burden of hydatidosis in endemic regions.

棘球蚴病是一种由细粒棘球绦虫和多房棘球绦虫引起的人畜共患疾病，在全球范围内对健康和经济构成重大挑战。这项研究评估了智利阿伊萨姆地区Capitán普拉特省农村社区、卫生专业人员和教育工作者对囊性包虫病的知识、态度和做法。对243名参与者进行的一项调查显示，人们普遍对这种疾病有很高的认识（81.6%），但各部门的知识水平和做法差异很大。危险行为，如允许狗自由走动和不当处理动物内脏，普遍存在，特别是在农村地区。虽然包括驱虫和教育在内的预防措施受到高度重视，但在贯彻执行方面仍然存在差距。研究结果强调需要有针对性的教育活动和具有文化敏感性的干预措施来解决行为风险因素。通过社区参与和部门间合作加强“同一个健康”倡议对于减轻流行地区的包虫病负担至关重要。

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引用次数: 0

The seasonality of respiratory syncytial virus and its associations with meteorological factors in Hong Kong, 2014–2023 2014-2023年香港呼吸道合胞病毒的季节性及其与气象因子的关系

IF 4.5 2区医学 Q1 INFECTIOUS DISEASES

One Health

Pub Date : 2025-12-01 Epub Date: 2025-08-18 DOI: 10.1016/j.onehlt.2025.101175

Qian Xiong , Zhuyao Rong , Jinjun Ran , Xiang Ren , Li Li

Background

Respiratory syncytial virus (RSV) is a common respiratory virus that causes respiratory diseases in all ages and causes severe diseases mainly among children and older adults. Understanding the seasonal pattern of RSV and its influencing factors is crucial for policy makers to optimize the timing of RSV immunization strategies. We explored the RSV seasonality and its associations with meteorological factors in Hong Kong from 2014 to 2023.

Methods

We collected weekly RSV surveillance data in Hong Kong between 2014 and 2023 from Centre for Health Protection (CHP) of Hong Kong. Three different approaches were applied to explore the RSV seasonality including the 50th percentile method, the average annual percentage (AAP) method, and the 2 % threshold method. A generalized additive model was used to explore the associations between RSV positive rate and meteorological factors.

Results

During 10-year study period, 44,722 specimens were positive for RSV with a positive rate of 2.81 % in Hong Kong. The RSV epidemic varied year-on-year, with annual and biannual epidemics observed. The three approaches identified similar RSV epidemic in Hong Kong, a total of 9 RSV epidemics were found. The RSV epidemics mainly occurred from mid-February to late September, with an average duration of approximately 6 months during the study years. We found that mean temperature was positively associated with RSV positive rate, while mean dew point temperature showed a negative association.

Conclusions

RSV epidemic varied year-on-year in Hong Kong, the 2 % threshold is recommended as an alert threshold for RSV epidemics. A One Health perspective might enhance future prevention strategies by incorporating broader environmental and intersectoral factors.

呼吸道合胞病毒（RSV）是一种常见的呼吸道病毒，可引起所有年龄段的呼吸道疾病，主要在儿童和老年人中引起严重疾病。了解RSV的季节特征及其影响因素对决策者优化RSV免疫策略的时机至关重要。研究了2014 - 2023年香港RSV季节特征及其与气象因子的关系。方法收集香港卫生防护中心2014 - 2023年每周RSV监测数据。采用50百分位法、年平均百分比法和2%阈值法三种不同的方法探讨RSV的季节性。采用广义加性模型探讨RSV阳性率与气象因子的关系。结果在10年的研究期间，香港共有44722份RSV标本呈阳性，阳性率为2.81%。RSV流行逐年变化，有一年一次和两年一次的流行。三种方法在香港发现了相似的RSV流行，共发现9例RSV流行。RSV流行主要发生在2月中旬至9月下旬，平均持续时间约为6个月。我们发现平均温度与RSV阳性率呈正相关，而平均露点温度与RSV阳性率呈负相关。结论香港地区RSV流行情况逐年变化，建议2%为RSV流行的预警阈值。“一个健康”的观点可以通过纳入更广泛的环境和部门间因素来加强未来的预防战略。

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引用次数: 0