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Anti-inflammatory Effect of Squalene Isolated from Simarouba glauca in Experimental Animal Model 青光眼角鲨烯在实验动物模型中的抗炎作用
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-08 DOI: 10.5530/pres.15.4.069
Svenia Periyapurath Jose, Sandya Sukumaran, Ratheesh Mohanan, Sangeeth Saji, Aditya Asish, Sajeev Martin George
Pharmacognosy Research,2023,15,4,658-666.DOI:10.5530/pres.15.4.069Published:October 2023Type:Original ArticleAuthors:Svenia Periyapurath Jose, Sandya Sukumaran, Ratheesh Mohanan, Sangeeth Saji, Aditya Asish, and Sajeev Martin George Author(s) affiliations:Svenia Periyapurath Jose1, Sandya Sukumaran1,*, Ratheesh Mohanan2, Sangeeth Saji2, Aditya Asish1, Sajeev Martin George3 1Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, Karnataka, INDIA. 2Department of Biochemistry, St. Thomas College, Palai, Kerala, INDIA. 3Department of Chemistry, St. Thomas College, Palai, Kerala, INDIA. Abstract:Background: Most dynamic area of scientific investigation is to identify the bioactive compounds and establish their potential health effects against chronic diseases. Multi-targeted compounds with fewer side effects has shown to be potential therapeutic agents. Objectives: To evaluate the anti-inflammatory effect of isolated Squalene (SQ), a triterpenoid from Simarouba glauca in carrageenan-induced acute inflammation. Materials and Methods: Squalene (SQ), a triterpenoid fraction was isolated from Simarouba glauca and characterized by FT-IR and NMR. Experimental animals were categorized into five groups, group I was control (0.5% DMSO in normal saline), group II received Carrageenan (Carr), group III received SQ and Carr, whereas group IV received diclofenac and Carr. After 1 hr, SQ and diclofenac (20mg/kg) were administered (i.p.). Carrageenan suspension was injected into the sub-plantar tissue of the right hind paw. Paw edema was determined 3 hours post-carrageenan administration. Rats were sacrificed and mRNA expression of TNF-α and IL-6, levels of PGE-2 and TBARS, activities of COX-2, SOD, catalase, GPx, MPO, and the level of nitrite were measured. Results: SQ at a dose of 5.0 mg/kg body weight was found to be the minimal dose for maximum edema inhibition. Serum levels of TNF-α, IL-6, PGE-2, NO, COX-2 and levels of TBARS and MPO were significantly reduced (p < 0.05). Antioxidant markers such as SOD, Catalse and GPx were increased significantly (p < 0.05). Conclusion: These results suggest the anti-inflammatory properties of SQ and its multi-targeted mechanism of action, meriting its potential therapeutic efficacy in various inflammatory diseases. Keywords:Antioxidants, Inflammation, MPO, PGE2, SqualeneView:PDF (520.4 KB)
出版日期:2023年10月类型:原创文章作者:Svenia Periyapurath Jose, Sandya Sukumaran, Ratheesh Mohanan, Sangeeth Saji, Aditya Asish, Sajeev Martin George作者单位:Svenia Periyapurath Jose1, Sandya Sukumaran1,*, Ratheesh Mohanan2, Sangeeth Saji2, Aditya Asish1, Sajeev Martin George3 1印度科学研究所无机物理化学系,班加罗尔,Karnataka,印度。2圣托马斯学院生物化学系,印度喀拉拉邦帕莱3印度喀拉拉邦帕莱圣托马斯学院化学系摘要:背景:科学研究最活跃的领域是鉴定生物活性化合物并确定其对慢性疾病的潜在健康作用。副作用小的多靶点化合物已被证明是潜在的治疗药物。目的:观察角鲨烯(一种从青光眼中提取的三萜)对卡拉胶引起的急性炎症的抗炎作用。材料与方法:从青光眼中分离得到角鲨烯(Squalene, SQ),并用红外光谱(FT-IR)和核磁共振(NMR)对其进行了表征。实验动物分为5组,ⅰ组为对照组(生理盐水中加入0.5% DMSO),ⅱ组给予卡拉胶(Carr),ⅲ组给予SQ和Carr,ⅳ组给予双氯芬酸和Carr。1小时后给予SQ和双氯芬酸(20mg/kg) (i.p)。右后爪足底下组织注射卡拉胶悬浮液。给予卡拉胶3小时后测定足跖水肿。处死大鼠,检测TNF-α、IL-6 mRNA表达、PGE-2、TBARS水平、COX-2、SOD、过氧化氢酶、GPx、MPO活性及亚硝酸盐水平。结果:SQ在5.0 mg/kg体重的剂量被发现是最大的水肿抑制的最小剂量。血清TNF-α、IL-6、PGE-2、NO、COX-2水平及TBARS、MPO水平均显著降低(p < 0.05)。SOD、过氧化氢酶、GPx等抗氧化指标显著升高(p < 0.05)。结论:提示SQ具有抗炎作用及其多靶点作用机制,对多种炎症性疾病具有潜在的治疗作用。关键词:抗氧化剂,炎症,MPO, PGE2, SqualeneView
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引用次数: 0
Physicochemical and in vitro Analysis of Herbal Drugs A. indica, C. longa, P. pinnata, P. corylifolia, W. fruticosa for Potential Effect in Psoriasis 中药籼米、龙葵、桄榔子、茯苓子对银屑病潜在疗效的理化及体外分析
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-08 DOI: 10.5530/pres.15.4.088
Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani Shivani S, Vikas Kumar Pal
Pharmacognosy Research,2023,15,4,831-840.DOI:10.5530/pres.15.4.088Published:October 2023Type:Original ArticleAuthors:Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, and Vikas Kumar Pal Author(s) affiliations:Arun Kumar, Saurabh Singh*, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, Vikas Kumar Pal School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, INDIA. Abstract:Background: Curcuma longa (Zingiberaceae), Azadirachta indica (Meliaceae), Psoralea corylifolia (Fabaceae), Pongamia pinnata (Fabaceae), and Woodfordia fruticosa (Lythraceae) stand as renowned medicinal plants in India. Traditionally, different parts of these plants have been employed for healing, particularly in the context of treating psoriasis and various other ailments. This catalyzed our investigation into the potential antipsoriatic properties of these botanicals. Objectives: We set out to evaluate the preliminary phytochemical analysis and in vitro antipsoriatic capabilities of acetone, ethanol, and water extracts derived from Curcuma longa, Azadirachta indica, Psoralea corylifolia, Pongamia pinnata, and Woodfordia fruticosa. Materials and Methods: The antipsoriatic potential of these extracts was assessed through the MTT assay, using HaCaT cells. Additionally, we conducted LDH assays and utilized confocal microscopy to gain further insights. Results: Our investigations unveiled the promising antiproliferative activity of these plants on skin keratinocytes. Notably, compounds A, B, and C demonstrated a significant decrease in cell viability compared to the control group. In contrast, compounds D and E did not exhibit significant differences compared to the control. Discussion and Conclusion: These findings substantiate the traditional uses of these plants in the treatment of psoriasis and underscore their potential as valuable resources in the quest for effective antipsoriatic treatments. Keywords:Azadirachta indica, Curcuma longa, haCaT cells, Pongamia pinnata, Psoralea corylifolia, Woodfordia fruticosaView:PDF (349.84 KB)
出版日期:2023年10月类型:原创文章作者:Arun Kumar, Saurabh Singh, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani和Vikas Kumar Pal作者:Arun Kumar, Saurabh Singh*, Bimlesh Kumar, Sheetu Wadhwa, Dileep Singh Baghel, Narendra Kumar Panday, Sachin Kumar Singh, Shivani, Vikas Kumar Pal Pharmaceutical Sciences School of medicine;可爱的专业大学,帕格瓦拉,旁遮普,印度。摘要/ Abstract摘要:背景:姜黄(姜科)、印楝科(楝科)、补骨脂(豆科)、桄榔子(豆科)和木足草(莱草科)是印度著名的药用植物。传统上,这些植物的不同部分被用于治疗,特别是在治疗牛皮癣和各种其他疾病的背景下。这催化了我们对这些植物药潜在的抗银屑病特性的研究。目的:对姜黄、印楝、补骨脂、凤尾草和木荆的丙酮、乙醇和水提取物进行初步的植物化学分析和体外抗银屑病能力的评价。材料和方法:利用HaCaT细胞,通过MTT法评估这些提取物的抗银屑病潜能。此外,我们进行了LDH测定,并利用共聚焦显微镜获得了进一步的见解。结果:我们的研究揭示了这些植物对皮肤角质形成细胞有良好的抗增殖活性。值得注意的是,与对照组相比,化合物A、B和C的细胞活力明显下降。相比之下,化合物D和E与对照组相比没有显着差异。讨论和结论:这些发现证实了这些植物在治疗银屑病中的传统用途,并强调了它们作为寻求有效抗银屑病治疗的宝贵资源的潜力。关键词:印楝,姜黄,haCaT细胞,凤尾莲,补骨脂,木果
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引用次数: 0
In vivo Investigation to Validate the Traditional Usage of Sorbaria tomentosa (Lindley) Reh. Root Extract against Alloxan-induced Diabetic Rats 毛毡Sorbaria tomentosa (Lindley) Reh.)传统用法的体内研究。根提取物抗四氧嘧啶诱导的糖尿病大鼠
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-08 DOI: 10.5530/pres.15.4.071
Monika Mehta, Richa Puri, Dechan Angmo, Pooja Boora, Sushila Rani
Pharmacognosy Research,2023,15,4,671-678.DOI:10.5530/pres.15.4.071Published:October 2023Type:Original ArticleAuthors:Monika Mehta, Richa Puri, Dechan Angmo, Pooja Boora, and Sushila Rani Author(s) affiliations:Monika Mehta*, Richa Puri, Dechan Angmo, Pooja Boora, Sushila Rani Department of Botany, Panjab University, Chandigarh, INDIA. Abstract:Background: DM is a complicated condition that impacts the handling of sugar, fat, and protein metabolism in our bodies. Medicinal herbs play a significant role in diabetes care. As a result, we focused on the plant components traditionally employed by regional medical professionals. Objectives: The current research was carried out to check if Sorbaria tomentosa (Lindley) Reh. (ST) the ethanolic root extracts anti-diabetic potential. ST is a member of the Rosaceae family commonly known by the common name "false spirae." The root extract of ST is used by the locals in the Kinnaur district of Himachal Pradesh to effectively treat diabetes. Materials and Methods: Plant ethanolic extracts were evaluated for their potential on alloxan-induced diabetic rats for 14 days. The animals were put into one of four treatment groups at random: a normal control group, not treated diabetic control group (150 mg/kg bw), a drug control group that got glibenclamide (5 mg/kg bw), and the last treatment group medicated with ST root extract (50 mg/kg BW). Liver, pancreas, and kidney histopathology were analyzed to correlate biochemical findings with histological changes. Results: Our results showed that the extract and medication-treated diabetic groups gained statistically significant weight (p≤0.001) and that their BGL went back to normal. Along with more common biological markers such as SGOT, SGPT, ALP, TC, TG, HDL, LDL, VLDL, creatinine level, uric acid, urea, and uric acid were measured. After the extract treated hyperglycaemic rats, all biochemical markers came under the normal range (p≤0.001). Improvement of the damaged structure of the liver, pancreas, and kidneys was observed after treatment with standard medication and root extracts of ST. Conclusion: Based on the data gathered from the tribal research area, to the best of our capacity, we have uncovered for the very first time the anti-diabetic efficacy of the plant parts. The empirical knowledge of previous generations is typically the basis for the traditional utilization of medicinal plants for controlling diabetes. Nevertheless, in vivo, research has assisted to discover the anti-diabetic potential of ST's ethanolic root extract and provides scientific proof to back up these claims. The plant component may also be used to create natural antidiabetic drugs that are effective. Keywords:Alloxan, Diabetes mellitus, Kinnaur, Sorbaria tomentosa, Traditional knowledge, Wistar ratsView:PDF (1.41 MB)
出版日期:2023年10月类型:原创作者:Monika Mehta, Richa Puri, Dechan Angmo, Pooja Boora, Sushila Rani作者单位:Monika Mehta*, Richa Puri, Dechan Angmo, Pooja Boora, Sushila Rani印度旁遮普大学植物学系,昌迪加尔摘要:背景:糖尿病是一种影响体内糖、脂肪和蛋白质代谢的复杂疾病。草药在糖尿病治疗中起着重要的作用。因此,我们将重点放在传统上由区域医疗专业人员使用的植物成分上。目的:本研究旨在探讨毛囊Sorbaria tomentosa (Lindley) Reh。(ST)乙醇根提取物的抗糖尿病潜能。ST是蔷薇科的一员,通常被称为“假螺旋”。喜马偕尔邦金纳尔地区的当地人使用ST的根提取物来有效治疗糖尿病。材料与方法:观察植物乙醇提取物对四氧嘧啶诱导的糖尿病大鼠的作用。随机分为正常对照组、未治疗糖尿病对照组(150 mg/kg bw)、格列本脲药物对照组(5 mg/kg bw)和ST根提取物(50 mg/kg bw) 4个治疗组。分析肝脏、胰腺和肾脏的组织病理学,将生化结果与组织学变化联系起来。结果:我们的研究结果显示,提取物组和药物治疗组的体重增加有统计学意义(p≤0.001),BGL恢复正常。同时测量SGOT、SGPT、ALP、TC、TG、HDL、LDL、VLDL、肌酐水平、尿酸、尿素和尿酸等更常见的生物标志物。提取物对高血糖大鼠处理后,各项生化指标均在正常范围内(p≤0.001)。用标准药物和ST.根提取物治疗后,观察到肝脏、胰腺和肾脏受损结构的改善。结论:根据从部落研究地区收集的数据,我们尽最大努力,首次发现了植物部分的抗糖尿病功效。前几代人的经验知识通常是传统利用药用植物控制糖尿病的基础。然而,在体内,研究已经帮助发现了ST的乙醇根提取物的抗糖尿病潜力,并提供了科学证据来支持这些说法。植物成分也可用于制造有效的天然抗糖尿病药物。关键词:四氧嘧啶,糖尿病,金牛,毛囊索巴利亚,传统知识,Wistar大鼠
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引用次数: 0
In vitro Urolithiasis Activity of Tridax procumbens Methanolic Extract on Calcium Oxalate Crystals Prepared by Precipitation Method 原杜仲甲醇提取物对沉淀法制备的草酸钙晶体的体外尿石活性研究
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-08 DOI: 10.5530/pres.15.4.070
Aithamraju Satishchandra, Alagarsamy V Alagarsamy, Radhika V Radhika, V Ravi Kumar, Bandi Narendhar, P Subhash Chandra Bose
Pharmacognosy Research,2023,15,4,667-670.DOI:10.5530/pres.15.4.070Published:October 2023Type:Original ArticleAuthors:Aithamraju Satishchandra, V. Alagarsamy, V. Radhika, V Ravi Kumar, Bandi Narendhar, and P. Subhash Chandra Bose Author(s) affiliations:Aithamraju Satishchandra1,*, V. Alagarsamy2, V. Radhika2, V Ravi Kumar1, Bandi Narendhar2, P. Subhash Chandra Bose3 1Department of Pharmacology, MNR College of Pharmacy, Fasalwadi, Sangareddy, Telangana, INDIA. 2Department of Pharmaceutical Chemistry, MNR College of Pharmacy, Fasalwadi, Sangareddy, Telangana, INDIA. 3Department of Pharmaceutics, MNR College of Pharmacy, Fasalwadi, Sangareddy, Telangana, INDIA. Abstract:Background: The main purpose of present to reduce the kidney stone with herbal drugs due increase in incidence rate of kidney stones significantly with change in life style from the last two decades. Aim and Methodology: The present study aimed to evaluate in vitro urolithiasis activity of Tridax procumbens on experimentally prepared calicium oxalate crystals. Calcium oxalate crystals were prepared by homogenous ppt method by using calium chloride and sodium oxalate. The crude extract was prepared by the simple maceration with methanol 1:3 ratio and the solvent was evaporated by rotary evaporator and two doses of extract selected i.e 10mg and 20 mg and compared against standard cytosine all were assayed against calcium oxalate crystals which were incubated in semi-permeable membrane with sulphuric acid. Results and Conclusion: The results were 68.02% (10 mg), 72.41% (20 mg) and 90% and we conclude that the Tridax procumbens was showed significant effect of urolithiasis. Keywords:Calcium oxalate crystals, Cytosine, PPT, Tridax procumbensView:PDF (197.05 KB)
出版日期:2023年10月类型:原创文章作者:Aithamraju Satishchandra, V. Alagarsamy, V. Radhika, V Ravi Kumar, Bandi narendra har, P. Subhash Chandra Bose作者单位:Aithamraju Satishchandra1,*, V. Alagarsamy2, V. Radhika2, V Ravi Kumar1, Bandi narendra dhar2, P. Subhash Chandra Bose3印度,Telangana, Fasalwadi, Sangareddy, MNR药学院药学系。2印度特伦甘纳邦药学学院药物化学系,法萨尔瓦迪,Sangareddy,印度3印度特伦加纳邦Sangareddy法萨尔瓦迪MNR药学院药剂学系摘要:背景:本研究的主要目的是探讨近二十年来肾结石发病率随着生活方式的改变而显著增加的中药治疗肾结石的疗效。目的与方法:研究原甘菊对草酸钙晶体的体外抑石作用。以氯化钙和草酸钠为原料,采用均相ppt法制备了草酸钙晶体。粗提物以甲醇1:3的比例简单浸渍制得,溶剂经旋转蒸发器蒸发,选择10mg和20mg两种剂量的提物与标准胞嘧啶进行比较,并与草酸钙晶体在硫酸半透膜中孵育进行测定。结果与结论:结果分别为68.02% (10 mg)、72.41% (20 mg)和90%,说明原豆三通对尿石症有显著的治疗作用。关键词:草酸钙晶体,胞嘧啶,PPT,三甘菊
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引用次数: 0
Additive Effects of High Fructose Corn Syrup (HFCS) in Experimental Oral Carcinogenesis 高果糖玉米糖浆(HFCS)在实验性口腔癌中的加性作用
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-08 DOI: 10.5530/pres.15.4.087
Kavitha Kalimuthu, Sindhu Ganapathy, Balamurugan Elumalai, Asha Kumarasamypillai Radha Thayammal, Veeran Veeravarmal, Vijayalakshmi Annamalai
Pharmacognosy Research,2023,15,4,819-830.DOI:10.5530/pres.15.4.087Published:October 2023Type:Original ArticleAuthors:Kavitha Kalimuthu, Sindhu Ganapathy, Balamurugan Elumalai, Asha Kumarasamypillai Radha Thayammal, Veeran Veeravarmal, and Vijayalakshmi Annamalai Author(s) affiliations:Kavitha Kalimuthu1, Sindhu Ganapathy1,2,*, Balamurugan Elumalai1, Asha Kumarasamypillai Radha Thayammal3, Veeran Veeravarmal4, Vijayalakshmi Annamalai5 1Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA. 2Department of Biochemistry, Government Arts College (Autonomous), Kumbakonam, Tamil Nadu, INDIA. 3Department of Biochemistry, Government Arts College, Paramakudi, Tamil Nadu, INDIA. 4Department of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College and Hospital, Annamalai Nagar, Tamil Nadu, INDIA. 5Plant Head, Galileovasan Offshore and Research and Development Private Limited, Nagapattinam, Tamil Nadu, INDIA. Abstract:Introduction: Nowadays, fructose uses dramatically increased in form of High-Fructose Corn Syrup (HFCS) found in juices and packed food. Sustained fructose utilization is detrimental to long-term human health. Objectives: To assess the additive effects of HFCS during 7,12-Dimethylbenz(a)Anthracene (DMBA)-induced Hamster Buccal Pouch Carcinogenesis (HBPCs) model. Materials and Methods: The animals were separated into eight groups: Group I; vehicle control; Group II (0.5% DMBA); Group III and IV (HFCS 8% and 25%); Group V (Sucrose 10%); Group VI and VII (0.5% DMBA+HFCS 8 and 25%) and VIII group (0.5% DMBA+Sucrose 10%) respectively for 14 weeks. After the 14th week of treatment; the tumor morphology, buccal histopathology, and biochemical markers were measured and compared with carcinogenic control as well as vehicle control. Observations and Results: The buccal pouch of golden Syrian hamsters developed well-differentiated squamous cell carcinoma after getting topical applications of 0.5% DMBA in liquid paraffin three times a week for 14 weeks. Although DMBA treatment alone caused 100% tumor development in hamsters, drinking water administration of HFCS at a concentration of 25%/kg body weight (b.w.) to DMBA-treated hamster greatly accelerated the development of oral tumors. Additionally, during DMBA-induced oral carcinogenesis, HFCS moderatingly increased the lipid peroxidation by-products, decreased the status of enzymatic and non-enzymatic antioxidants, modulated the levels of phase I and phase II detoxification agents, and favored the excretion of carcinogenic metabolite. Conclusion: The present study concludes that the additive effect of HFCS relies on its altered peroxidative and antioxidant function as well as effects on phase I and II detoxification enzymes during DMBA-induced hamster buccal pouch carcinogenesis. Taken together the current study described that HFCS induced oral tumour development. From this study we suggested HFCS usage to be curtaile
Pharmacognosy Research,2023,15,4,819-830.DOI:10.5530/pres.15.4.087发表时间:2023 年 10 月类型:原创文章作者:Kavitha Kalimuthu, Sindhu Ganapathy, Balamurugan Elumalai, Asha Kumarasamypillai Radha Thayammal, Veeran Veeravarmal, and Vijayalakshmi Annamalai作者单位:中国科学院上海生命科学研究院:Kavitha Kalimuthu1, Sindhu Ganapathy1,2,*, Balamurugan Elumalai1, Asha Kumarasamypillai Radha Thayammal3, Veeran Veeravarmal4, Vijayalakshmi Annamalai5 1Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.2Department of Biochemistry, Government Arts College (Autonomous), Kumbakonam, Tamil Nadu, INDIA.3Department of Biochemistry, Government Arts College, Paramakudi, Tamil Nadu, INDIA.4Department of Oral and Maxillofacial Pathology, Rajah Muthiah Dental College and Hospital, Annamalai Nagar, Tamil Nadu, INDIA.5 印度泰米尔纳德邦纳加帕蒂纳姆伽利略瓦桑近海和研发私人有限公司工厂主管。摘要:引言:如今,果汁和包装食品中的高果糖玉米糖浆(HFCS)形式的果糖用量急剧增加。持续使用果糖不利于人类的长期健康。目标:评估高果糖糖浆在 7,12-二甲基苯并(a)蒽(DMBA)诱导的仓鼠颊囊致癌模型(HBPCs)中的添加效应。材料与方法:动物分为八组:第一组;药物对照;第二组(0.5% DMBA);第三组和第四组(HFCS 8%和 25%);第五组(蔗糖 10%);第六组和第七组(0.5% DMBA+HFCS 8%和 25%)以及第八组(0.5% DMBA+蔗 糖 10%),分别治疗 14 周。治疗第 14 周后,测量肿瘤形态、口腔组织病理学和生化指标,并与致癌物对照组和药物对照组进行比较。观察结果每周三次在液体石蜡中外敷 0.5% DMBA,连续 14 周后,金色叙利亚仓鼠的颊囊出现了分化良好的鳞状细胞癌。虽然单独使用 DMBA 会导致仓鼠 100% 肿瘤发生,但在饮用水中添加浓度为 25%/kg 体重(b.w.)的 HFCS 会大大加速口腔肿瘤的发展。此外,在 DMBA 诱导的口腔癌发生过程中,HFCS 会适度增加脂质过氧化副产物,降低酶和非酶抗氧化剂的状态,调节 I 期和 II 期解毒剂的水平,并促进致癌代谢物的排泄。结论本研究的结论是,在 DMBA 诱导的仓鼠颊囊癌变过程中,HFCS 的添加效应依赖于其过氧化和抗氧化功能的改变,以及对 I 期和 II 期解毒酶的影响。总之,本研究描述了 HFCS 诱导口腔肿瘤发生的情况。通过这项研究,我们建议减少使用 HFCS。关键词:抗氧化剂 解毒酶 DMBA 仓鼠 HFCS 脂质过氧化 口腔癌查看:PDF (704.72 KB)
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引用次数: 0
Is COVID-19 Related to the Recent Surge in Research on Houttuynia cordata (Thunb)? COVID-19与最近鱼腥草(Thunb)研究激增有关吗?
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-08 DOI: 10.5530/pres.15.4.074
Poonam Singh Deo, Sweety Angelirie Kharumnuid, Moses M Naga, Hangsing P Hangsing
Pharmacognosy Research,2023,15,4,693-704.DOI:10.5530/pres.15.4.074Published:October 2023Type:Original ArticleAuthors:Poonam Singh Deo, Sweety Angelirie Kharumnuid, Moses M. Naga, and P. Hangsing Author(s) affiliations:Poonam Singh Deo*, Sweety Angelirie Kharumnuid, Moses M. Naga, P. Hangsing Department of Library and Information Science, North Eastern Hill University, Library and Information Science, Umshing Mawkynroh, Shillong, Meghalaya, INDIA. Abstract:Background of the Study: Houttuynia cordata is an herbal medicinal plant with a variety of ethnomedicinal properties. The plant extract has potent anti-inflammatory and antioxidant effects, which may help to reduce the complications associated with diabetes. Additionally, it is used as an anti-inflammation, antidote, astringent, anti-bacterial, and anti-viral. Objectives: The present study is a scientometric analysis of Houttuynia cordata during 1992-2021 as covered in the SCOPUS database to find out the citation impact, growth rate, and research output of Houttuynia cordata research during a three-decade period. Materials and Methods: SCOPUS database was used to download data for three decades. The information gathered was quantified using bibliometrics; further, VOS viewer was used for visualizing the keyword network. Results: The study revealed that from 2005 onwards, there was an increase in Houttuynia cordata research and publication. China turns out to be at the top with the maximum number of research publications on Houttuynia cordata. Pharmacology, Toxicology, and Pharmaceutics were the top subject areas that constituted the leading publication. Keywords 'Traditional Medicine' and 'Medicinal Plants' were used mainly during the year 1992-2018, however, from 2019-2021 there is a tremendous shift from the keywords such as 'Traditional Medicine', and 'Medicinal Plants' to keywords such as 'Coronavirus' 'COVID-19' and 'Pandemic', indicating that research on Houttuynia cordata relating to COVID-19 and Pandemic has become an extensive area of research from 2019 onwards. Conclusion: This study concludes that research on Houttuynia cordata has been slow since the early years, with a significant surge during the COVID-19 pandemic. The onset of the COVID-19 pandemic has certainly reconfirmed the relevance of Houttuynia cordata as a medicinal herb. Additionally, this study will help researchers understand the current state of the Houttuynia cordata research and can act as an information road map to further explore research on its medicinal importance which may benefit humanity in the future. Keywords:Coronavirus, COVID-19, Houttuynia cordata, Medicinal plants, Scientometric Analysis, Traditional medicineView:PDF (1.12 MB)
《生药学研究》,2023,15,4693 -704. doi:10.5530/pres.15.4.074出版日期:2023年10月类型:原创文章作者:Poonam Singh Deo, Sweety Angelirie Kharumnuid, Moses M. Naga, P. Hangsing作者:Poonam Singh Deo*, Sweety Angelirie Kharumnuid, Moses M. Naga, P. Hangsing东北山大学图书馆信息科学系,Umshing Mawkynroh, Shillong, Meghalaya,印度。摘要:研究背景:鱼腥草是一种具有多种民族药材特性的中草药植物。这种植物提取物具有有效的抗炎和抗氧化作用,这可能有助于减少与糖尿病相关的并发症。此外,它被用作抗炎、解毒剂、收敛剂、抗菌和抗病毒。目的:本研究对SCOPUS数据库1992-2021年鱼腥草数据进行科学计量分析,了解30年间鱼腥草研究的被引影响、增长率和研究产出。材料与方法:采用SCOPUS数据库下载30年数据。使用文献计量学对收集到的信息进行量化;利用VOS查看器对关键词网络进行可视化。结果:研究表明,从2005年开始,鱼腥草的研究和发表有所增加。中国是鱼腥草研究论文发表数量最多的国家。药理学、毒理学和药剂学是构成主要出版物的顶级学科领域。关键词“传统医学”和“药用植物”主要在1992-2018年期间使用,然而,从2019-2021年,关键词“传统医学”和“药用植物”出现了巨大的转变,如“冠状病毒”、“COVID-19”和“大流行”,这表明从2019年起,与COVID-19和大流行相关的鱼腥草研究已成为一个广泛的研究领域。结论:本研究认为,鱼腥草的研究自早期以来一直进展缓慢,在新冠肺炎大流行期间出现了明显的激增。COVID-19大流行的爆发无疑再次证实了鱼腥草作为一种草药的相关性。此外,本研究将帮助研究人员了解鱼腥草研究的现状,并可以作为信息路线图,进一步探索其药用价值的研究,在未来可能造福人类。关键词:冠状病毒,COVID-19,鱼腥草,药用植物,科学计量分析,传统医学view:PDF (1.12 MB)
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引用次数: 0
Alternanthera sessilis: A Review of Literature on the Phytoconstituents, Traditional Usage and Pharmacological Activities of Green and Red Cultivar 绿、红相间花的植物成分、传统用法及药理活性的文献综述
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-08 DOI: 10.5530/pres.15.4.067
Omilla Ragavan, Sze Cheng Chan, Yi En Goh, Vuanghao Lim, Yoke Keong Yong
Pharmacognosy Research,2023,15,4,636-652.DOI:10.5530/pres.15.4.067Published:October 2023Type:Review ArticleAuthors:Omilla Ragavan, Sze Cheng Chan, Yi En Goh, Vuanghao Lim, and Yoke Keong Yong Author(s) affiliations:Omilla Ragavan1, Sze Cheng Chan1,2, Yi En Goh1,2, Vuanghao Lim3, Yoke Keong Yong1,* 1Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, MALAYSIA. 2School of Science, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya, Selangor, MALAYSIA. 3Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, MALAYSIA. Abstract:The weed Alternanthera sessilis, having Green (ASG) and Red (ASR) cultivars, is a member of the Amaranthaceae. Both cultivars are known to possess high medicinal and nutraceutical values as they are widely utilized in traditional medicine. Populations from various Asian regions commonly consume this medicinal weed as part of diet and as therapeutic agent. In general, both cultivars have been employed for treating a broad range of human ailments including cardiovascular diseases, diabetes, hypertension, and inflammatory disorders such as asthma, bronchitis and hepatitis apart from its administration as a painkiller. Following its ethnomedicinal uses, an attempt was made to review and consolidate the phytochemical constituents of ASG and ASR discovered from previous studies that utilized advanced technologies, respective traditional application among different ethnicities of Asia and their established pharmacological properties. All the information in this study was acquired through a literature search of research databases, namely ScienceDirect, Scopus, PubMed and Google Scholar using keywords such as Alternanthera sessilis, Alternanthera sessilis red, dwarf copperleaf and sessile joyweed. The results of each study were reviewed to identify its relevance and the cultivar that was being investigated. All relevant studies were collected and its subsequent results were reported and discussed to provide insights into the health enhancing qualities of ASG and ASR. Inspection of phytoconstituents in ASG and ASR showed the presence of polyphenol, flavonoid, carotenoid, terpenes and alkaloid with polyphenol being the major chemical group found in both cultivars. It was also revealed that whilst ASR is traditionally consumed in China, Malaysia, Singapore, and Taiwan, indigenous usage of ASG is more common in nations such as Sri Lanka, India, and Indonesia. Both ASG and ASR showed potent anti-oxidant, anti-hyperglycemic, antimicrobial, antifungal and hepatoprotective effects while the anti-inflammatory, anti-cancer and analgesic properties were disclosed in ASG only. Further processing and commercialization of this remedial weed as a product benefiting the wellbeing of humans is recommended as Alternanthera sessilis has high potential to be utilized as a curative agent while being a vital ingredient that can be included in
《生药学研究》,2023,15,4636 -652. doi:10.5530/pres.15.4.067出版日期:2023年10月类型:综述作者:Omilla Ragavan, Sze Cheng Chan, Yi En Goh, Vuanghao Lim, Yoke Keong Yong作者:Omilla Ragavan1, Sze Cheng Chan1,2, Yi En Goh1,2, Vuanghao Lim3, Yoke Keong Yong1,* 1马来西亚雪兰州雪当市马来西亚布特拉大学医学与健康科学系人体解剖学系。2马来西亚莫纳什大学理学院,Jalan Lagoon Selatan, Bandar Sunway, Subang Jaya,雪兰莪州,马来西亚3马来西亚圣士大学高级医学和牙科研究所,马来西亚槟城伯塔姆摘要/ Abstract摘要:苋科植物Alternanthera sessilis有Green (ASG)和Red (ASR)两种栽培品种。这两个品种都被认为具有很高的药用和营养价值,因为它们在传统医学中被广泛使用。来自亚洲不同地区的人们通常食用这种药用杂草作为饮食的一部分和治疗剂。一般来说,除了作为止痛药外,这两个品种已被用于治疗广泛的人类疾病,包括心血管疾病、糖尿病、高血压和炎症性疾病,如哮喘、支气管炎和肝炎。在民族医学应用的基础上,本文对利用先进技术研究发现的ASG和ASR的植物化学成分、各自在亚洲不同民族中的传统应用及其已建立的药理特性进行了综述和整合。本研究的所有信息均通过ScienceDirect、Scopus、PubMed、Google Scholar等研究数据库进行文献检索,检索关键词为Alternanthera sessilis、Alternanthera sessilis red、dwarf copperleaf、essessile joyweed。对每项研究的结果进行回顾,以确定其相关性和正在研究的品种。我们收集了所有相关研究,并对其后续结果进行了报告和讨论,以提供对ASG和ASR的健康促进质量的见解。两种品种的植物成分均含有多酚、类黄酮、类胡萝卜素、萜烯和生物碱,其中多酚是两种品种的主要化学成分。研究还显示,虽然ASR传统上在中国、马来西亚、新加坡和台湾消费,但在斯里兰卡、印度和印度尼西亚等国家,ASR的本土使用更为普遍。ASG和ASR均具有较强的抗氧化、抗高血糖、抗菌、抗真菌和保护肝脏的作用,而只有ASG具有抗炎、抗癌和镇痛的作用。建议进一步加工和商业化这种治疗杂草,作为一种有益于人类健康的产品,因为无叶莲子作为一种治疗剂具有很高的潜力,同时也是一种重要的成分,可以包括在日常消费中。关键词:无柄参,矮铜叶,药理性质,植物成分,无柄参
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引用次数: 0
Traditional Use of Medicinal Plants against ENT Diseases by the Tribals of Purulia District, West Bengal, India 传统使用药用植物对抗耳鼻喉疾病的部落普里亚地区,西孟加拉邦,印度
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-08 DOI: 10.5530/pres.15.4.073
Rajani Kanta Mahato, Ghanashyam Mahato
Pharmacognosy Research,2023,15,4,687-692.DOI:10.5530/pres.15.4.073Published:October 2023Type:Original ArticleAuthors:Rajani Kanta Mahato, and Ghanashyam Mahato Author(s) affiliations:Rajani Kanta Mahato, Ghanashyam Mahato* Department of Botany, Achhruram Memorial College, Jhalda, West Bengal, INDIA. Abstract:Background: Since ancient times natural plant parts were extensively used for the treatment and prevention of Ear, Nose and Throat related diseases. ENT related diseases are caused by various types of micro-organism. Eleven ethnic groups (Bhumij, Birhor, Gond, Sabar, Kharwar, Kurmi, Lodha, Malpaharya, Sardar, Oraon, Santal) present in Purulia district. Objectives: This study aims to record herbal plants used in the traditional treatment of ENT related ailments in Purulia district of West Bengal. Materials and Methods: Semi-structured questionnaire, interviews with traditional healers and focused group discussion were used to gather ethnobotanical data Results: This investigation listed 24 species in 20 plant families that are beneficial for treating ENT disorders in the Purulia district of West Bengal. Conclusion: The primary source of information on therapeutic plants is traditional healers. This information has been passed down orally from one generation to the next, but it appears that it is fading from modern society since young people are not interested to continue this tradition. So, the traditional wisdom on ethnobotanicals should be digitized for future references in India. Keywords:ENT, Ethnobotany, PuruliaView:PDF (292.56 KB)
《生药学研究》,2023,15,4,687-692.DOI:10.5530/pres.15.4.073出版日期:2023年10月类型:原创文章作者:Rajani Kanta Mahato和Ghanashyam Mahato作者:Rajani Kanta Mahato, Ghanashyam Mahato*印度西孟加拉Jhalda Achhruram纪念学院植物系。摘要:背景:自古以来,天然植物部位就被广泛用于治疗和预防耳鼻喉相关疾病。耳鼻喉科相关疾病是由多种微生物引起的。普鲁里亚区有11个民族(布米吉、比霍尔、贡德、萨巴尔、哈尔瓦尔、库尔米、洛达、马尔帕哈里亚、萨达尔、奥拉恩、桑塔尔)。目的:本研究旨在记录西孟加拉邦普鲁里亚地区传统治疗耳鼻喉科相关疾病的草药植物。材料和方法:采用半结构化问卷调查、传统治疗师访谈和焦点小组讨论的方法收集民族植物学数据。结果:本调查列出了西孟加拉邦Purulia地区20个植物科的24种有益于治疗耳鼻喉疾病的植物。结论:中药资料的主要来源是中医。这个信息已经口头相传了一代又一代,但它似乎正在从现代社会中消失,因为年轻人对继续这个传统不感兴趣。因此,民族植物学的传统智慧应该数字化,以备将来在印度参考。关键词:耳鼻喉科,民族植物学,PuruliaView:PDF (292.56 KB)
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引用次数: 0
Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats 补充tirupatiensis结核根对链脲佐菌素诱导的糖尿病大鼠氧化应激和肾毒性的减弱
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-08 DOI: 10.5530/pres.15.4.086
Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, Saddala Rajeswara Reddy
Pharmacognosy Research,2023,15,4,813-818.DOI:10.5530/pres.15.4.086Published:October 2023Type:Original ArticleAuthors:Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, and Saddala Rajeswara Reddy Author(s) affiliations:Thopireddy Lavanya1, Kakarla Chandra Mohan2, Kesireddy Sathyavelu Reddy3, Saddala Rajeswara Reddy4,* 1Department of Zoology, KVR Government College for Women (A), Cluster University, Kurnool, Andhra Pradesh, INDIA. 2Department of Zoology, SCNR Government Degree College, Proddatur, Andhra Pradesh, INDIA. 3Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, INDIA. 4Department of Biotechnology, Division of Ethnopharmacology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam, Andhra Pradesh, INDIA. Abstract:Background: The endemic plant of Seshachalam hills, Eastern Ghats, India, known as Pimpinella tirupatiensis (Pt). Objectives: It was examined in this study for its protective effects against oxidative damage in the kidney of Streptozotocin (STZ)-induced diabetic rats. Materials and Methods: After the induction of diabetes with Streptozotocin (40 mg kg-1 b.w), PTAq, an aqueous extract of Pt was directed orally at a dose of 750 mg kg-1 b.w. day-1. Results: Diabetic rats displayed significant decreases in Glutathione (GSH), ascorbic acid, and Vitamin E content (p<0.01) and significant elevations in lipid peroxidation (as MDA), uric acid content, and Xanthine Oxidase (XOD) activity (p<0.01). However, PTAq supplementation in the diabetic group resulted in significant (p<0.01) increases in Glutathione (GSH), Ascorbic Acid (AA), and Vitamin E content and declined MDA content, uric acid content, and XOD activity. Conclusion: The results advocate that Pt has the potential to avert diabetic complications triggered by oxidative stress in experimental diabetic rats and could have therapeutic implications for diabetes management in the future. Keywords:Ascorbic acid, Glutathione, Lipid peroxidation, Non-enzymatic antioxidants, Pimpinella tirupatiensisView:PDF (1.78 MB)
《生药学研究》,2023,15,4,813-818.DOI:10.5530/pres.15.4.086出版日期:2023年10月类型:原创文章作者:Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy和Saddala Rajeswara Reddy作者:Thopireddy lavany1, Kakarla Chandra Mohan2, Kesireddy Sathyavelu Reddy3, Saddala Rajeswara Reddy4,* 1印度KVR政府女子学院(A), Cluster University, Kurnool, Andhra Pradesh, INDIA。2印度安得拉邦政府学位学院动物学系,普拉达尔;3 S.V.大学动物学系,印度安得拉邦蒂鲁帕蒂4德拉威大学草药研究与自然科学学院生物技术系民族药理学学部,印度安得拉邦库邦。摘要/ Abstract摘要:背景:印度东高止山脉Seshachalam山特有植物Pimpinella tirupatiensis (Pt)。目的:探讨其对链脲佐菌素(STZ)诱导的糖尿病大鼠肾脏氧化损伤的保护作用。材料和方法:用链脲佐菌素(40 mg kg-1 b.w)诱导糖尿病后,PTAq, Pt的水提取物以750 mg kg-1 b.w d -1的剂量口服。结果:糖尿病大鼠谷胱甘肽(GSH)、抗坏血酸和维生素E含量显著降低(p<0.01),脂质过氧化(如MDA)、尿酸含量和黄嘌呤氧化酶(XOD)活性显著升高(p<0.01)。然而,糖尿病组添加PTAq可显著(p<0.01)提高谷胱甘肽(GSH)、抗坏血酸(AA)和维生素E含量,降低丙二醛(MDA)含量、尿酸含量和XOD活性。结论:本研究结果提示铂有可能避免实验性糖尿病大鼠氧化应激引起的糖尿病并发症,并可能在未来的糖尿病治疗中具有治疗意义。关键词:抗坏血酸,谷胱甘肽,脂质过氧化,非酶抗氧化剂,tirupatiensis
{"title":"Attenuation of Oxidative Stress and Nephrotoxicity with Supplementation of Pimpinella tirupatiensis Tuberous Root in Streptozotocin-induced Diabetic Rats","authors":"Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, Saddala Rajeswara Reddy","doi":"10.5530/pres.15.4.086","DOIUrl":"https://doi.org/10.5530/pres.15.4.086","url":null,"abstract":"Pharmacognosy Research,2023,15,4,813-818.DOI:10.5530/pres.15.4.086Published:October 2023Type:Original ArticleAuthors:Thopireddy Lavanya, Kakarla Chandra Mohan, Kesireddy Sathyavelu Reddy, and Saddala Rajeswara Reddy Author(s) affiliations:Thopireddy Lavanya1, Kakarla Chandra Mohan2, Kesireddy Sathyavelu Reddy3, Saddala Rajeswara Reddy4,* 1Department of Zoology, KVR Government College for Women (A), Cluster University, Kurnool, Andhra Pradesh, INDIA. 2Department of Zoology, SCNR Government Degree College, Proddatur, Andhra Pradesh, INDIA. 3Department of Zoology, S.V. University, Tirupati, Andhra Pradesh, INDIA. 4Department of Biotechnology, Division of Ethnopharmacology, School of Herbal Studies and Naturo Sciences, Dravidian University, Kuppam, Andhra Pradesh, INDIA. Abstract:Background: The endemic plant of Seshachalam hills, Eastern Ghats, India, known as Pimpinella tirupatiensis (Pt). Objectives: It was examined in this study for its protective effects against oxidative damage in the kidney of Streptozotocin (STZ)-induced diabetic rats. Materials and Methods: After the induction of diabetes with Streptozotocin (40 mg kg-1 b.w), PTAq, an aqueous extract of Pt was directed orally at a dose of 750 mg kg-1 b.w. day-1. Results: Diabetic rats displayed significant decreases in Glutathione (GSH), ascorbic acid, and Vitamin E content (p<0.01) and significant elevations in lipid peroxidation (as MDA), uric acid content, and Xanthine Oxidase (XOD) activity (p<0.01). However, PTAq supplementation in the diabetic group resulted in significant (p<0.01) increases in Glutathione (GSH), Ascorbic Acid (AA), and Vitamin E content and declined MDA content, uric acid content, and XOD activity. Conclusion: The results advocate that Pt has the potential to avert diabetic complications triggered by oxidative stress in experimental diabetic rats and could have therapeutic implications for diabetes management in the future. Keywords:Ascorbic acid, Glutathione, Lipid peroxidation, Non-enzymatic antioxidants, Pimpinella tirupatiensisView:PDF (1.78 MB)","PeriodicalId":19813,"journal":{"name":"Pharmacognosy Research","volume":"33 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crassocephalum crepidioides (Asteraceae) Benth S. Moore Leaves Fractions Attenuate Dyslipidemia and Atherogenic Indices in Diabetic Rats 山菖蒲叶提取物对糖尿病大鼠血脂异常及动脉粥样硬化的影响
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-11-08 DOI: 10.5530/pres.15.4.080
Opeyemi Oluwayemisi Ayodele, Funmilayo Dorcas Onajobi, Emeka Emea Okoro, Omolaja Osoniyi
Pharmacognosy Research,2023,15,4,761-770.DOI:10.5530/pres.15.4.080Published:October 2023Type:Original ArticleAuthors:Opeyemi Oluwayemisi Ayodele, Funmilayo Dorcas Onajobi, Emeka Emea Okoro, and Omolaja Osoniyi Author(s) affiliations:Opeyemi Oluwayemisi Ayodele1,2,*, Funmilayo Dorcas Onajobi2, Emeka Emea Okoro1, Omolaja Osoniyi2,3 1Department of Biochemistry, College of Basic and Applied Sciences, Mountain Top University, Prayer, Ogun, NIGERIA. 2Department of Biochemistry, School of Basic Medical Sciences, Benjamin S. Carson (Snr.) College of Health and Medical Sciences, Babcock University, Ilishan-Remo, Ogun, NIGERIA. 3Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Osun, NIGERIA. Abstract:Background: Diabetes mellitus, a metabolic and endocrine disorder, is associated with an impaired lipid profile that can result in increased atherogenic indices. The effects of the aqueous and hexane fractions of C. crepidioides leaves on the lipid profile and atherogenic indices of diabetic rats were investigated in this study. Materials and Methods: Varied concentrations (50-200 mg/kg body weight) of the aqueous (CAF) and hexane (CHF) fractions of C. crepidioides were assayed against streptozotocin-induced diabetic rats. Histological examinations of the pancreas were carried out using hematoxylin and eosin staining procedures. Experimental rats were randomly divided into 9 groups of 6 rats each and orally treated for 14 days. Results: The tested concentrations (50, 100 and 200 mg/kg) of CAF and CHF significantly (p < 0.05) reduced plasma glucose (51.3-62.2%), plasma and liver triglycerides (up to 50.5% in plasma; 66.1% in the liver), total cholesterol (up to 49.0% in plasma; 35.3% in the liver), low-density lipoprotein-cholesterol (up to 96.0 and 91.0% in the plasma and liver), very low-density lipoprotein-cholesterol (up to 50.5% in plasma; 55.0% in the liver), and the atherogenic indices elevated by diabetes induction. The high-density lipoprotein-cholesterol concentrations were significantly increased (plasma: 73.60-127.60%; liver: 108.70-152.5%) in CAF and CHF-treated diabetic rats compared to the diabetic control. Histological examination showed improved tissue architecture in the pancreas of the diabetic-treated rats compared to the diabetic control. Conclusion: C. crepidioides leaf fractions possess hypolipidemic and anti-atherogenic activities. Therefore, the plant could be useful in managing diabetes, dyslipidemia, and cardiovascular conditions. Keywords:Atherogenic indices, Diabetes mellitus, Dyslipidemia, Histological, Solvent fractionsView:PDF (619.52 KB)
出版日期:2023年10月类型:原创文章作者:Opeyemi Oluwayemisi Ayodele, Funmilayo Dorcas Onajobi, Emeka Emea Okoro, Omolaja Osoniyi作者:Opeyemi Oluwayemisi ayodeli 1,2,*, Funmilayo Dorcas Onajobi2, Emeka Emea Okoro1, Omolaja Osoniyi 2,31尼日利亚奥冈市山顶大学基础与应用科学学院生物化学系。2基础医学院生物化学系,Benjamin S. Carson (Snr)巴布科克大学卫生与医学学院,尼日利亚奥贡伊利山-雷莫。3 Obafemi Awolowo大学生物化学与分子生物学教研室,尼日利亚奥松Ile-Ife摘要:背景:糖尿病是一种代谢和内分泌紊乱,与脂质谱受损相关,可导致动脉粥样硬化指数增加。本研究探讨了山参叶水馏分和己烷馏分对糖尿病大鼠血脂及动脉粥样硬化指标的影响。材料与方法:采用不同浓度(50 ~ 200 mg/kg体重)的水(CAF)和己烷(CHF)对链脲佐菌素诱导的糖尿病大鼠的作用进行了研究。采用苏木精和伊红染色方法对胰腺进行组织学检查。实验大鼠随机分为9组,每组6只,口服治疗14 d。结果:CAF和CHF浓度(50、100和200 mg/kg)显著(p < 0.05)降低血糖(51.3-62.2%)、血浆和肝脏甘油三酯(50.5%);66.1%在肝脏),总胆固醇(高达49.0%在血浆;低密度脂蛋白-胆固醇(在血浆和肝脏中分别高达96.0和91.0%),极低密度脂蛋白-胆固醇(在血浆中高达50.5%;肝脏55.0%),糖尿病诱导的动脉粥样硬化指数升高。高密度脂蛋白-胆固醇浓度显著升高(血浆:73.60-127.60%;与糖尿病对照组相比,CAF和chf治疗的糖尿病大鼠肝脏:108.70-152.5%)。组织学检查显示,与糖尿病对照组相比,糖尿病治疗大鼠胰腺的组织结构有所改善。结论:山参叶提取物具有降血脂和抗动脉粥样硬化作用。因此,这种植物可能对治疗糖尿病、血脂异常和心血管疾病有用。关键词:动脉粥样硬化指标,糖尿病,血脂异常,组织学,溶剂组分
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