Pediatric Dental Journal最新文献_第2页

Characterization of gene expression profile of dental pulp stem cells from human exfoliated deciduous teeth (SHED) in down syndrome 唐氏综合征人脱落乳牙牙髓干细胞基因表达谱的研究

IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Pediatric Dental Journal

Pub Date : 2025-09-17 DOI: 10.1016/j.pdj.2025.100360

Itaru Komine , Yuta Chiba , Hiroshi Sato , Sae Oka , Keigo Yoshizaki , Aya Yamada , Satoshi Fukumoto

Objectives

Down syndrome is caused by trisomy of chromosome 21 and shows various phenotype in organs. The patients often suffer dental anomalies such as hypodontia and enamel hypoplasia, however, the mechanism of dental anomalies associated to Down syndrome remains unclear. To clarify the details of the dental phenotype of Down syndrome, we performed RNA-sequence (RNA-seq) of dental pulp stem cells from human exfoliated deciduous tooth (SHED).

Materials and methods

Three children with Down syndrome were selected as the patient group, and three healthy children were selected as the control group. Dental pulp was collected from extracted teeth during the replacement period between the ages of 5 and 8, and SHED was cultured. RT-qPCR was used to confirm whether there was a difference in the expression level of the gene on chromosome 21. MTT assay and colony formation assay was performed to examine cell proliferation ability. RNA-seq was performed to comprehensively analyze the gene expression difference between control group and Down syndrome group.

Results

SHED of control group and Down syndrome group showed no significant difference in cell shape and proliferation activity, while, the expression of COL6A1 was around 1.5-fold change upregulated in Down syndrome group, suggesting that the gene of chromosome 21 became trisomy. RNA-seq analyses revealed that the genes related to organ morphogenesis were upregulated. Furthermore, several genes important for tooth development was raised as significantly upregulated genes.

Conclusion

Genetic analysis using SHED was considered a useful tool for elucidating the mechanisms of dental anomalies in Down syndrome.

目的唐氏综合征是由21号染色体三体引起的，在器官上表现出多种表型。唐氏综合征患者常出现牙齿畸形，如牙髓缺损、牙釉质发育不全等，但与唐氏综合征相关的牙齿畸形机制尚不清楚。为了阐明唐氏综合征牙齿表型的细节，我们对人脱落乳牙（SHED）的牙髓干细胞进行了rna -序列（RNA-seq）分析。材料与方法选取唐氏综合征患儿3例作为患者组，健康儿童3例作为对照组。在5岁至8岁期间，从拔除的牙齿中收集牙髓，并培养SHED。采用RT-qPCR验证该基因在21号染色体上的表达水平是否存在差异。MTT法和集落形成法检测细胞增殖能力。采用RNA-seq综合分析对照组与唐氏综合征组基因表达差异。结果对照组和唐氏综合征组的shed在细胞形态和增殖活性上无显著差异，而COL6A1的表达在唐氏综合征组上调1.5倍左右，提示21号染色体基因发生三体。RNA-seq分析显示，与器官形态发生相关的基因表达上调。此外，几个对牙齿发育重要的基因被上调为显著的基因。结论SHED基因分析是阐明唐氏综合征牙畸形发生机制的有效工具。

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引用次数: 0

Causes and prevention of near-miss choking events in childcare facilities 1. child factors 托儿设施中险些窒息事件的原因及预防孩子的因素

IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Pediatric Dental Journal

Pub Date : 2025-09-09 DOI: 10.1016/j.pdj.2025.100357

Kai Shibahara , Luna Osakabe , Akiko Ishizaki , Hyosong Kwon , Naofumi Shimomura , Tomomi Sugiyama , Miyuki Hamano , Shouji Hironaka , Takahiro Funatsu

Introduction

This study investigates the incidence of near-miss choking events in childcare facilities and their association with children's eating behaviors and developmental status to develop prevention strategies.

Methods

A web-based survey was conducted among childcare workers employed at municipal facilities, social welfare corporations, and the National Council of Childcare Centers. Of the 1661 respondents, 1648 consenting participants were included in the analysis. We collected data on their places of work, sociodemographic characteristics, causes and prevention of choking near-miss incidents, and physical conditions of the children involved.

Results

Eating behaviors most frequently associated with near-miss choking events were stuffing food into the mouth, large bite size, insufficient chewing during meals, swallowing food without chewing, and fast eating. Children with growth-related concerns, those with developmental delays, or those who caused anxiety for caregivers were significantly more likely to exhibit these risky eating behaviors.

Conclusions

Problematic eating behaviors are strongly linked to children's growth, development, and caregiver anxiety; therefore, careful observation and support are essential to prevent choking events.

本研究旨在调查儿童保育机构中险些窒息事件的发生率及其与儿童饮食行为和发育状况的关系，以制定预防策略。方法采用网络调查方法，对市政设施、社会福利公司和全国托儿中心理事会的托儿工作者进行调查。在1661名受访者中，有1648名同意参与分析。我们收集了他们的工作地点、社会人口特征、呛死未遂事件的原因和预防以及所涉及儿童的身体状况等数据。结果与差点窒息事件最相关的坐姿行为是将食物塞进嘴里、咬得太大、吃饭时咀嚼不足、不咀嚼就吞下食物以及吃得太快。有生长相关问题的儿童，有发育迟缓的儿童，或者那些给照顾者带来焦虑的儿童，更有可能表现出这些危险的饮食行为。结论：问题饮食行为与儿童的生长发育和照顾者焦虑密切相关；因此，仔细观察和支持对于防止窒息事件至关重要。

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引用次数: 0

Association between food difficulty and oral function in school-aged children 学龄儿童进食困难与口腔功能的关系

IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Pediatric Dental Journal

Pub Date : 2025-09-09 DOI: 10.1016/j.pdj.2025.100359

Haruka Koyama , Kaori Ishii , Yusuke Suzuki , Syo Kuroe , Toshio Wani , Shinichi Negishi

Objective

This study aimed to investigate the relationship between children's subjective perception of food difficulty and the physical properties of foods, and to examine how these factors are associated with oral function development.

Methods

A questionnaire survey on “food difficulty” was conducted on 25 types of foods with 133 first-grade elementary school students (70 boys and 63 girls). The physical properties of the foods (hardness, cohesiveness, and adhesiveness) were measured. The masticatory difficulty score for each child was calculated by integrating texture values with their subjective evaluations. In addition, oral function measurements were conducted, including occlusal force, lip-closing strength, tongue pressure, masticatory performance, and masticatory path width. Associations between masticatory difficulty scores and oral function were analyzed using Spearman's rank correlation.

Results

Foods with higher hardness and cohesiveness were rated as more difficult to eat. Children who perceived hard and cohesive foods as difficult to eat tended to exhibit a lower occlusal force and reduced masticatory performance, suggesting an underdeveloped masticatory function. However, the association with adhesiveness was limited, indicating the potential influence of non-physical factors such as preference or food shape.

Conclusion

Children's subjective perception of food difficulty is closely related to food texture, particularly hardness and cohesiveness, and is associated with oral function development. These findings suggest that incorporating food texture into oral health assessment and dietary education is a beneficial approach, as it may help foster eating habits that promote the development of masticatory function in children.

目的探讨儿童进食困难的主观感知与食物物理性质的关系，以及这些因素与口腔功能发育的关系。方法对133名小学一年级学生（男生70人，女生63人）进行25种食物“进食困难”问卷调查。测定了食品的物理性能（硬度、内聚性和粘附性）。每个孩子的咀嚼困难评分是通过纹理值和他们的主观评价相结合来计算的。此外，还进行了口腔功能测量，包括咬合力、闭唇强度、舌压、咀嚼性能和咀嚼路径宽度。采用Spearman秩相关分析咀嚼困难评分与口腔功能之间的关系。结果硬度和黏结性越高的食物越难食用。认为坚硬和粘连的食物难以进食的儿童往往表现出较低的咬合力和咀嚼功能下降，表明咀嚼功能不发达。然而，与粘附性的联系是有限的，表明非物理因素如偏好或食物形状的潜在影响。结论儿童对食物困难的主观感知与食物质地尤其是硬度和黏结性密切相关，并与口腔功能发育有关。这些发现表明，将食物质地纳入口腔健康评估和饮食教育是一种有益的方法，因为它可能有助于培养促进儿童咀嚼功能发展的饮食习惯。

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引用次数: 0

Non-plaque-induced gingivitis and oral complications in a pediatric patient on long-term mechanical ventilation – A case report 长期机械通气儿童非牙菌斑性牙龈炎及口腔并发症1例报告

IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Pediatric Dental Journal

Pub Date : 2025-09-03 DOI: 10.1016/j.pdj.2025.100358

Yuta Hirofuji, Itaru Komine, Saki Hirofuji, Fumiko Takayama, Mitsuki Chiba, Aya Yamada, Satoshi Fukumoto

Background

Oral care is essential for preventing ventilator-associated pneumonia (VAP) in intensive care units (ICUs) patients. Patients in pediatric ICUs (PICUs) require specialized oral management due to anatomical and developmental factors, yet detailed reports are limited.

Case presentation

We report a 9-year-old girl with chronic heart failure who developed ventilator-associated gingivitis (VAG) and other oral complications during long-term mechanical ventilation. Oral management was conducted collaboratively by pediatric dentists, dental hygienists, nurses, and physicians.

Conclusion

This case underscores the importance of early, continuous oral care and interdisciplinary collaboration in managing oral complications and supporting overall health in ventilated PICUs patients.

背景：在重症监护病房（icu）患者中，口腔护理对于预防呼吸机相关性肺炎（VAP）至关重要。由于解剖和发育因素，儿童重症监护病房（picu）的患者需要专门的口腔管理，但详细的报道有限。病例介绍：我们报告一名患有慢性心力衰竭的9岁女孩，在长期机械通气过程中出现呼吸机相关性牙龈炎（VAG）和其他口腔并发症。口腔管理是由儿科牙医、牙科保健师、护士和医生共同进行的。结论本病例强调了早期、持续的口腔护理和跨学科合作对控制picu通气患者口腔并发症和支持整体健康的重要性。

引用次数: 0

Review of hypodontia and its impact on oral health related quality of life in children 牙下缺失及其对儿童口腔健康相关生活质量影响的综述

IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Pediatric Dental Journal

Pub Date : 2025-08-19 DOI: 10.1016/j.pdj.2025.100356

Angel Rauniyar , Jad Clarke , Constance Law , Neeta Prabhu

Background

Hypodontia can be defined as the developmental absence of one or more teeth, excluding third molars. It can affect both primary and permanent dentitions and lead to challenges in aesthetics, speech and masticatory function as well as emotional and social wellbeing.

Objective

This review will explore the background to hypodontia and assess its impact on the oral health related quality of life (OHRQoL) in children.

Results

There is limited literature that assesses the OHRQoL in younger age groups with hypodontia (<11 years of age) and the effect of oral rehabilitation on OHRQoL in children. Conclusions: Further research on the impact of treatment on patient satisfaction and the OHRQoL in children during their mixed dentition phase is necessary to guide the development of management strategies tailored to the unique needs of children with hypodontia.

牙缺症可以定义为发育性缺一颗或多颗牙齿，第三磨牙除外。它可以影响原牙和恒牙，并导致美学、言语和咀嚼功能以及情感和社会健康方面的挑战。目的探讨下颌畸形的发病背景及对儿童口腔健康相关生活质量的影响。结果较低年龄（11岁）下颌缺损患者的OHRQoL及口腔康复对儿童OHRQoL的影响文献较少。结论：有必要进一步研究治疗对混合牙列期儿童患者满意度和OHRQoL的影响，以指导制定针对下牙症儿童独特需求的管理策略。

引用次数: 0

Knowledge, perception, attitude, practice and awareness of dentists and dental students about molar-incisor hypomineralization: A systematic review 牙医和牙科学生对臼齿-门牙低矿化的认识、感知、态度、实践和意识：系统综述

IF 0.8 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Pediatric Dental Journal

Pub Date : 2025-08-02 DOI: 10.1016/j.pdj.2025.100355

Lilibeth-Stephania Escoto-Vasquez , Mario Alberto Alarcón-Sánchez , Julieta Sarai Becerra-Ruiz , Ruth Rodríguez-Montaño , Sarah Monserrat Lomelí-Martínez , Diana Elizabeth Aguirre-Cortés , Artak Heboyan

Aim

Molar-incisor hypomineralization (MIH) is a developmental enamel defect that presents diagnostic and treatment challenges for dental professionals. Understanding the knowledge, perception, attitude, practice, and awareness of MIH is essential for improving its management in pediatric dentistry. This systematic review evaluates the knowledge, perception, attitude, practice, and awareness of MIH among dentists and dental students.

Methods

A systematic search was conducted across PubMed, Scopus, ScienceDirect, Web of Science, EBSCO, and Google Scholar following PRISMA guidelines. Cross-sectional studies were included, and the methodological quality was assessed using the Joanna Briggs Institute (JBI) checklist.

Results

Out of 2499 identified articles, 38 met the inclusion criteria, comprising 11,129 participants. Data collection was primarily conducted via Email (44.73 %), Google Forms (31.57 %) and direct questionnaire (15.78 %). Most studies assessed knowledge (89.47 %), followed by perception (60.52 %), practice (47.36 %), attitude (34.21 %), and awareness (10.52 %). Pediatric dentists demonstrated higher levels in all domains.

Conclusion

The findings indicate a need for improved education and training on MIH. Dental institutions and regulatory bodies may use this informati-on to enhance curricula and clinical guidelines, promoting better MIH management in pediatric dentistry.

臼齿-切牙低矿化（MIH）是一种发育性牙釉质缺陷，对牙科专业人员提出了诊断和治疗挑战。了解对MIH的认识、认知、态度、实践和意识，对改善儿童牙科的MIH管理至关重要。本系统综述评估了牙医和牙科学生对MIH的知识、感知、态度、实践和意识。方法按照PRISMA指南，在PubMed、Scopus、ScienceDirect、Web of Science、EBSCO和b谷歌Scholar上进行系统检索。纳入横断面研究，并使用乔安娜布里格斯研究所（JBI）检查表评估方法学质量。结果共纳入2499篇文献，38篇符合纳入标准，共纳入11,129名受试者。数据收集主要通过Email（44.73%）、谷歌Forms（31.57%）和直接问卷（15.78%）进行。大多数研究评估知识（89.47%），其次是感知（60.52%）、实践（47.36%）、态度（34.21%）和意识（10.52%）。儿科牙医在所有领域都表现出更高的水平。结论研究结果表明，需要加强对MIH的教育和培训。牙科机构和监管机构可以利用这些信息来加强课程和临床指南，促进儿童牙科更好的MIH管理。

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引用次数: 0

Juvenile ossifying fibroma and aneurysmal bone cyst in the mandible: A case report and mini review of literature 青少年下颌骨骨化纤维瘤及动脉瘤性骨囊肿1例报告及文献复习

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Pediatric Dental Journal

Pub Date : 2025-07-03 DOI: 10.1016/j.pdj.2025.100354

Fatma Wageeh Attya , Walaa Hussein Abu El-Ela , Basma Abdelrahman Ahmed , Iman Mohamed Helmy

Background

Hybrid tumors of fibro-osseous and giant cell lesions are rare presentations with few reported cases.

Case presentation

Here we present a case of a 9-year-old boy with a swollen right posterior mandible. The lesion was diagnosed as a hybrid Juvenile trabecular ossifying fibroma (JTrOF) with aneurysmal bone cyst (ABC). This article displays the case clinically, radiographically, surgically, and histologically, besides discussing in a mini review the possible etiopathogenesis of this type of hybrid lesions.

Conclusion

We reported a rare case of hybrid JTrOF and ABC with a recommendation of further reporting of similar cases for better understanding of the pathogenesis and detecting the best treatment methods.

背景：纤维骨和巨细胞混合肿瘤是一种罕见的肿瘤，目前报道的病例很少。我们在此报告一个9岁男孩右后下颌骨肿大的病例。诊断为混合型幼年小梁骨化纤维瘤（JTrOF）合并动脉瘤性骨囊肿（ABC）。本文从临床、影像学、外科和组织学角度对该病例进行了分析，并对这种混合型病变的可能病因进行了讨论。结论本研究报告了一例罕见的JTrOF合并ABC的病例，建议今后进一步报道类似病例，以更好地了解其发病机制和寻找最佳治疗方法。

引用次数: 0

Establishing reference values for maximum occlusal force in Japanese children using an individual-tooth-type capacitive pressure distribution sensor 利用单齿式电容式压力分布传感器建立日本儿童最大咬合力参考值

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Pediatric Dental Journal

Pub Date : 2025-06-11 DOI: 10.1016/j.pdj.2025.100352

Takashi Kuroki , Kaori Ishii , Yusuke Suzuki , Sho Kuroe , Julie Miyazaki , Satoshi Murata , Haruka Koyama , Risa Matsumoto , Naoya Antsuki , Kosuke Heki , Kentaro Igarashi , Hirohiko Hirano , Takashi Ogihara , Tomonori Hoshino , Takehiko Shimizu , Kazumasa Morikawa , Shinichi Negishi

Introduction

Assessing oral function during growth is vital for evaluating the dental arch and jawbone development. Occlusal force assessment, along with tongue pressure, is part of the criteria for diagnosing “oral functional development disorder.” However, reference values for these evaluations are lacking, highlighting the need for standardized values during growth. Therefore, we aimed to create age-specific reference values for the maximum occlusal force in Japanese elementary school children with a newly developed individual-tooth capacitive pressure distribution sensor.

Materials and methods

This cross-sectional survey involved 383 children (175 boys and 208 girls) from all grades in an elementary school in Chiba Prefecture, Japan. A single-tooth capacitive pressure distribution sensor was used to measure maximum occlusal force, which was then compared to the Occlusal Force Meter GM10. Measurements were taken of the first permanent molar or second primary molar if the first molar had not erupted. The average of three trials per side was calculated for each participant.

Results

The results showed that boys exhibited greater occlusal force than girls. Furthermore, the transition of occlusal force from first to sixth grade followed a two-phase S-shaped pattern, reflecting physiological growth factors such as first molar eruption and root development, followed by the lateral tooth exchange period with second primary molar exfoliation.

Conclusion

The maximum occlusal force increases nonlinearly during childhood and varies by sex. The new sensor exhibited strong correlation with traditional measurement devices. These results can help set reference values that can aid in diagnosing oral functional developmental disorders in children.

在生长过程中评估口腔功能对于评估牙弓和颌骨发育至关重要。咬合力评估，连同舌压，是诊断“口腔功能发育障碍”标准的一部分。然而，缺乏这些评价的参考值，突出表明在成长过程中需要标准化的值。因此，我们的目的是利用新开发的单个牙齿电容压力分布传感器，为日本小学生的最大咬合力创建特定年龄的参考值。材料与方法本横断面调查涉及日本千叶县一所小学各年级383名儿童（175名男生和208名女生）。采用单齿电容式压力分布传感器测量最大咬合力，并与咬合力计GM10进行比较。测量第一恒磨牙或第二乳牙，如果第一磨牙没有爆发。计算了每个参与者每方三次试验的平均值。结果男孩的咬合力明显大于女孩。此外，牙合力从1级到6级的转变遵循两个阶段的s型模式，反映了生理生长因素，如第一磨牙萌出和根发育，然后是侧牙交换期，第二磨牙脱落。结论最大咬合力在儿童期呈非线性增长，且因性别而异。该传感器与传统测量装置具有很强的相关性。这些结果可以帮助建立参考值，可以帮助诊断儿童口腔功能发育障碍。

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引用次数: 0

Corrigendum to “Relationship between childhood caries and social background: Regarding the novel emerged correlation between induced abortion and dental caries” [Pediatric Dental J 35 (1) (2025) 100341] “儿童龋齿与社会背景的关系：关于人工流产与龋齿之间新出现的相关性”的更正[儿科牙科J 35 (1) (2025) 100341]

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Pediatric Dental Journal

Pub Date : 2025-05-21 DOI: 10.1016/j.pdj.2025.100350

Takafumi Nagao , Naoki Nakao , Masataka Nagao , Hiroko Oka , Ayumu Nakashima , Mitsuhiro Uchida , Ayumu Ito , Ryota Nomura , Kazuhiro Shimamura , Akira Namera , Takahiro Harada , Kazuhiro Murata , Kouki Hatori

引用次数: 0

Demographic and socioeconomic determinants of maternal knowledge and confidence in promoting infant and toddler oral health: An exploratory study 人口统计学和社会经济因素对促进婴幼儿口腔健康的母亲知识和信心的影响：一项探索性研究

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Pediatric Dental Journal

Pub Date : 2025-05-20 DOI: 10.1016/j.pdj.2025.100351

Hayat Alghutaimel , Adeeb Alnajashi , Meshaal Alahmari , Sultan Alshamrani , Zaid Alonazi , Hasan Jamal

Introduction

Infancy and toddlerhood are unique periods that lay the foundations for a child's oral health. Proper nutrition, feeding practices, and oral care habits during these periods influence oral and general health. The present study explores the effect of demographics, socioeconomic variables, health-related factors, and information sources on expectant mothers' knowledge and confidence in promoting infants' and toddlers' oral health (ITOH).

Methods

A questionnaire was used to identify participants’ ages, nationalities, education, employment, incomes, and previous motherhood experience. Availability of health insurance, access to healthcare, attitude toward visiting the dentist, attitude toward fluoride, and sources of ITOH information were also recorded. Ten questions on factors influencing ITOH were used to assess knowledge. Self-reported confidence was captured using a five-point scale.

Results

The results demonstrated limited awareness of ITOH evidence-based practices, particularly concerning breast- and bottle-feeding and fluoride exposure. Low knowledge levels were evident for young participants, first-time mothers, participants with low incomes, and those who reported negative opinions toward fluoride. Low confidence levels were evident for young participants, first-time mothers, and those who had no formal education. Dentists emerged as the most reliable source of information, correlating with higher maternal knowledge than web searches and social media.

Conclusion

Socioeconomic factors, particularly household income and previous motherhood experience, are significant determinants of maternal ITOH knowledge and confidence levels, in addition to demographic variables, such as age and education level. The findings underscore the need for targeted educational interventions and call for efforts to establish public access to reliable information sources on child oral health.

婴儿期和幼儿期是儿童口腔健康的独特时期。在这些时期，适当的营养、喂养方法和口腔护理习惯会影响口腔和全身健康。本研究探讨了人口统计学、社会经济变量、健康相关因素和信息来源对准妈妈促进婴幼儿口腔健康知识和信心的影响。方法采用问卷调查法，对调查对象的年龄、国籍、学历、就业、收入、生育经历等进行调查。还记录了健康保险的可获得性、获得保健的机会、对看牙医的态度、对氟化物的态度以及ITOH信息的来源。对影响ITOH因素的10个问题进行知识评估。自我报告的信心是用五分制衡量的。结果表明，对ITOH循证实践的认识有限，特别是在母乳喂养和奶瓶喂养以及氟化物暴露方面。年轻参与者、初次母亲、低收入参与者和报告对氟化物持负面看法的参与者的知识水平明显较低。对于年轻的参与者、第一次做母亲的人以及没有受过正规教育的人来说，信心水平明显较低。牙医成为最可靠的信息来源，与网络搜索和社交媒体相比，牙医与更高的孕产妇知识相关。结论社会经济因素，特别是家庭收入和生育经验，是影响产妇ITOH知识和信心水平的重要因素，此外还有人口统计学变量，如年龄和教育水平。研究结果强调需要有针对性的教育干预措施，并呼吁努力使公众能够获得有关儿童口腔健康的可靠信息来源。

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引用次数: 0