Preventive medicine最新文献

Awareness and use of pre-exposure prophylaxis and awareness of treatment-as-prevention among adults in the United States: National estimates and associations with exposure to the Let's Stop HIV Together campaign, 2022–2024 美国成年人接触前预防的认识和使用以及治疗即预防的认识：2022-2024年全国估计和与接触“让我们一起阻止艾滋病毒”运动的联系

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-05-01 Epub Date: 2026-02-11 DOI: 10.1016/j.ypmed.2026.108532

Ryan S. Paquin , Vanessa Boudewyns , Hannah Getachew-Smith , Jo Ellen Stryker , Jennifer D. Uhrig

Objective

Benchmarks for public awareness of pre-exposure prophylaxis (PrEP) and human immunodeficiency virus (HIV) Treatment-as-Prevention (TasP) are sparse, and evidence about whether public health communication campaigns are associated with awareness and use is lacking. This study assessed whether exposure to the Centers for Disease Control and Prevention's (CDC) Let's Stop HIV Together campaign was associated with self-reported PrEP and TasP awareness and PrEP use.

Methods

Data were drawn from the 2022–2024 SpringStyles, a probability-based online survey of adults in the United States. Weighted logistic regression models assessed PrEP awareness, TasP awareness, and PrEP use by sociodemographic characteristics, prior HIV testing, and campaign exposure.

Results

Awareness of PrEP and TasP increased from 2022 to 2024, reaching 38.0% and 39.0%, respectively. Respondents who recalled the CDC's campaign were significantly more likely to be aware of PrEP (52.9% vs 34.1%) and TasP (55.9% vs 35.8%), and to report PrEP use (1.9% vs. 1.0%).

Conclusions

These nationally representative, repeated cross-sectional estimates reveal gains in PrEP and TasP awareness over time. The association of campaign exposure with PrEP and TasP awareness and PrEP use underscores the importance of federally funded health communication initiatives to end the HIV epidemic in the United States.

目的：暴露前预防（PrEP）和人类免疫缺陷病毒（HIV）治疗即预防（TasP）的公众意识的基准缺乏，关于公共卫生宣传运动是否与意识和使用相关的证据缺乏。这项研究评估了接触疾病控制和预防中心（CDC）的“让我们一起阻止艾滋病毒”运动是否与自我报告的PrEP和TasP意识和PrEP使用有关。方法数据来自2022-2024年SpringStyles，这是一项基于概率的美国成年人在线调查。加权逻辑回归模型通过社会人口学特征、既往HIV检测和运动暴露评估PrEP意识、TasP意识和PrEP使用情况。结果从2022年到2024年，PrEP和TasP的知晓率分别达到38.0%和39.0%。回忆起CDC运动的受访者更有可能意识到PrEP（52.9%对34.1%）和TasP(55.9%对35.8%)，并报告使用PrEP（1.9%对1.0%）。这些具有全国代表性的、重复的横断面估计表明，随着时间的推移，PrEP和TasP的认识有所提高。运动暴露与PrEP和TasP意识和PrEP使用的关联强调了联邦资助的卫生传播倡议在美国结束艾滋病毒流行的重要性。

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引用次数: 0

Injunctive substance use norms among substance-naïve youth in the United States: Differences by sexual identity and sex assigned at birth 美国substance-naïve青少年的禁止性物质使用规范：性别认同和出生时性别分配的差异

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-05-01 Epub Date: 2026-02-11 DOI: 10.1016/j.ypmed.2026.108531

Evan A. Krueger, Audrey Hang Hai

Background

Sexual minority (SM) youth are more likely than heterosexual youth to engage in substance use. Injunctive norms, or perceptions of others' substance use attitudes, contribute to youth substance use initiation and progression.

Methods

Among substance-naïve youth (ages 12–17; N = 7628) in the 2023 National Survey on Drug Use and Health, we examined differences in perceived parental, close friend, and personal disapproval of cigarette smoking, marijuana experimentation, monthly marijuana use, and near-daily alcohol use across five sexual identity groups (heterosexual, gay, bisexual, different term, unsure) and sex assigned at birth.

Results

Across groups and substances, youth perceived the highest substance use disapproval from parents (range = 72.4% – 97.4%), followed by personal disapproval (range = 52.1% - 87.7%) and disapproval by close friends (range = 48.6% - 81.6%). In multivariable models, bisexual, different term, and unsure youth reported lower close friend (IRR range = 0.89–0.97) and personal (IRR range = 0.89–0.92) disapproval, compared to heterosexual youth. SM females reported lower close friend and personal disapproval than heterosexual females.

Conclusions

SM youth perceive more permissive norms towards substance use. Prevention strategies addressing peer norms and personal permissiveness may be critical for addressing SM youth substance use inequities.

性少数群体（SM）青少年比异性恋青少年更容易吸毒。禁令规范或对他人物质使用态度的看法有助于青少年物质使用的开始和发展。方法：在2023年全国药物使用和健康调查中substance-naïve青少年（12-17岁；N = 7628）中，我们检查了五种性别认同群体（异性恋、同性恋、双性恋、不同称呼、不确定）和出生时的性别，在感知父母、亲密朋友和个人对吸烟、大麻实验、每月使用大麻和几乎每天使用酒精的反对程度上的差异。结果在不同人群和物质中，青少年对药物使用的不赞成度最高的是父母（范围为72.4% ~ 97.4%），其次是个人（范围为52.1% ~ 87.7%）和亲密朋友（范围为48.6% ~ 81.6%）。在多变量模型中，与异性恋青年相比，双性恋、不同术语和不确定的青年报告的亲密朋友（IRR范围= 0.89-0.97）和个人（IRR范围= 0.89-0.92）的不赞成程度较低。与异性恋女性相比，SM女性对亲密朋友和个人的不满程度较低。结论ssm青少年对药物使用有更宽松的规范。解决同伴规范和个人放纵的预防策略可能是解决SM青少年物质使用不公平问题的关键。

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引用次数: 0

Clinic-based SNAP enrollment as a strategy to strengthen food security 以诊所为基础的SNAP注册作为加强粮食安全的战略。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-04-01 Epub Date: 2026-01-29 DOI: 10.1016/j.ypmed.2026.108519

Matthew C. Guido , Madeline P. Maier , Alister F. Martin

引用次数: 0

Rates and characteristics of firearm access rules among U.S. parents of high-school age teens. 美国高中生父母枪支获取规则的比率和特征。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-03-20 DOI: 10.1016/j.ypmed.2026.108553

Laura A Seewald, Matthew G Myers Mph, Marc A Zimmerman, Maureen A Walton, Maya Haasz, Patrick M Carter

Objective: Firearm access is a risk factor for U.S. teen firearm injuries. We explore parental firearm rules for teens to inform prevention strategies.

Methods: Nationally representative web-based survey (6/2020-7/2020) among U.S. parents of teens (ages 14-18; N = 2727) to estimate what proportion of parents maintain rules for teens, characterize these rules, and examine factors associated with having rules. Bivariate and multivariate analyses were performed.

Results: Overall, 17.6% of parents never discussed firearm rules with their teen. For those with rules, 48.2% prohibited access, 42.8% allowed supervised access, and 8.9% allowed unsupervised access. Multivariable regression showed establishing rules was less likely among male parents (AOR = 0.63) and more likely among those reporting higher parental monitoring (AOR = 1.99), household firearm ownership (AOR = 3.99), and teen safety training (AOR = 4.40). Ordinal regression identified parents with permissive access rules were more likely male (AOR = 1.56), non-Hispanic White (AOR = 1.58), with teens that received safety training (AOR = 10.22); while parents of younger children (ages <10; AOR = 0.66) and reporting greater parental monitoring (AOR = 0.58) were less likely to have permissive rules.

Conclusions: Nearly 20% of U.S. parents lack firearm rules for teens. Among those with rules, many parents allow unsupervised access. Interventions should engage both firearm-owning and non-owning families to prevent teen firearm injuries.

目的：枪支接触是美国青少年火器伤害的一个危险因素。我们探讨父母的枪支规则，为青少年提供预防策略。方法：在美国青少年（14-18岁；N = 2727）的父母中进行具有全国代表性的网络调查（2020年6月至2020年7月），以估计父母为青少年制定规则的比例，这些规则的特征，并检查与制定规则相关的因素。进行了双变量和多变量分析。结果：总体而言，17.6%的父母从未与他们的孩子讨论过枪支规则。在有规则的用户中，48.2%的用户禁止访问，42.8%的用户允许有监督访问，8.9%的用户允许无监督访问。多变量回归显示，在男性父母中建立规则的可能性较小（AOR = 0.63），而在父母监督程度较高（AOR = 1.99）、家庭枪支拥有率（AOR = 3.99）和青少年安全培训（AOR = 4.40）的人群中建立规则的可能性较大。有序回归发现，父母有宽松的访问规则更可能是男性（AOR = 1.56），非西班牙裔白人（AOR = 1.58），青少年接受安全培训（AOR = 10.22）；结论：近20%的美国父母缺乏针对青少年的枪支规定。在有规定的学校中，许多家长允许在无人监督的情况下进入。干预措施应该包括拥有枪支和不拥有枪支的家庭，以防止青少年枪支伤害。

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引用次数: 0

Child access prevention laws and firearm storage practices among households with children in 24 U.S. states, 2021-2024. 2021-2024年美国24个州有孩子家庭的儿童接触预防法律和枪支储存实践。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-03-18 DOI: 10.1016/j.ypmed.2026.108552

Yi-Fang Lu, Mark T Berg

Objective: To examine whether the presence and strength of child access prevention (CAP) laws are associated with secure firearm storage among households with children and whether overall state firearm policy restrictiveness moderates these associations.

Methods: We linked Behavioral Risk Factor Surveillance System data (2021-2024) with three firearm law databases. The sample included 26,466 firearm owners with children in households across 24 U.S. states. Unsecure storage was defined as having at least one loaded and unlocked firearm in the home. Logistic regression models estimated the odds of unsecure storage associated with CAP laws, state firearm policy restrictiveness, and their interaction.

Results: Overall, 7.0% of households in CAP states stored at least one firearm loaded and unlocked, compared to 11.8% in non-CAP states. After adjusting for covariates, the association between CAP laws and unsecure storage varied by state firearm policy restrictiveness: CAP laws were linked to a greater reduction in unsecure storage in states with less restrictive policy environments.

Conclusions: CAP laws may play an important role in promoting secure storage in states where broader firearm policy supports are limited. Further research is needed to understand how CAP laws might operate across differing state policy contexts to affect child safety.

目的：研究儿童接触预防（CAP）法律的存在和力度是否与有儿童家庭的安全枪支储存有关，以及整体国家枪支政策限制是否缓和了这些关联。方法：我们将行为风险因素监测系统数据（2021-2024）与三个枪支法律数据库联系起来。样本包括美国24个州的26466名家庭中有孩子的枪支拥有者。不安全存储被定义为家中至少有一支上膛且未上锁的枪支。逻辑回归模型估计了与CAP法律、州枪支政策限制及其相互作用相关的不安全存储的几率。结果：总体而言，在CAP州，7.0%的家庭至少有一支上膛且未上锁的枪支，而在非CAP州，这一比例为11.8%。在调整协变量后，CAP法律和不安全储存之间的关系因州枪支政策限制而异：CAP法律与政策限制较少的州的不安全储存的更大减少有关。结论：在广泛的枪支政策支持有限的州，CAP法律可能在促进安全储存方面发挥重要作用。需要进一步的研究来了解CAP法律如何在不同的州政策背景下影响儿童安全。

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引用次数: 0

Beyond binary comparisons: A Bayesian dose-response meta-analysis of adherence to the planetary health diet and risks of all-cause mortality and cardiovascular outcomes in adults. 超越二元比较：坚持行星健康饮食与成人全因死亡率和心血管结局风险的贝叶斯剂量反应荟萃分析

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-03-18 DOI: 10.1016/j.ypmed.2026.108551

Khuc Thi Hong Hanh, Tran Quang Duc, Nguyen Di Khanh, Dang Dang Khoa, Nguyen Thi Hoa Huyen, Nguyen Huynh Phuong Anh

Objectives: The Planetary Health Diet (PHD) is associated with lower mortality and cardiovascular disease (CVD) risk, but evidence on specific CVD subtypes and risk patterns across the full range of adherence remains limited. To assess associations between PHD adherence and all-cause mortality, cardiovascular mortality, and CVDs, and to evaluate dose-response relationships.

Methods: We searched four databases from inception to January 2026 for prospective cohort studies in adults. Hazard ratios were pooled using random-effects models for highest vs. lowest adherence. Bayesian hierarchical dose-response models with centered RIDIT scores assessed graded associations. Study quality and evidence certainty were evaluated using the Newcastle-Ottawa Scale and NutriGrade.

Results: 23 studies were included. Highest adherence was associated with reduced risk of all-cause mortality (17%), cardiovascular mortality (16%), and total CVDs (18%). Dose-response analyses revealed risk reductions beginning at quintile 3 for all-cause mortality and total CVDs, and at quintile 4 for cardiovascular mortality. Highest adherence was associated with lower risks of coronary heart disease, ischemic heart disease, heart failure, and atrial fibrillation, but not myocardial infarction. Most studies were of high quality; the meta-evidence ranged from moderate to high.

Conclusions: Randomized trials are needed to confirm causality and assess clinical effectiveness.

目的：行星健康饮食（PHD）与较低的死亡率和心血管疾病（CVD）风险相关，但在整个依从性范围内关于特定CVD亚型和风险模式的证据仍然有限。评估博士依从性与全因死亡率、心血管死亡率和心血管疾病之间的关系，并评估剂量-反应关系。方法：我们检索了4个数据库，从建立到2026年1月的成人前瞻性队列研究。使用随机效应模型对最高依从性和最低依从性的风险比进行汇总。以RIDIT评分为中心的贝叶斯分级剂量反应模型评估了分级关联。使用纽卡斯尔-渥太华量表和NutriGrade评估研究质量和证据确定性。结果：共纳入23项研究。最高依从性与全因死亡率（17%）、心血管死亡率（16%）和总心血管疾病（18%）风险降低相关。剂量反应分析显示，全因死亡率和总心血管疾病死亡率的风险降低始于第3分位数，心血管死亡率的风险降低始于第4分位数。最高的依从性与较低的冠心病、缺血性心脏病、心力衰竭和心房颤动风险相关，但与心肌梗死无关。大多数研究都是高质量的；元证据的范围从中等到高。结论：需要随机试验来确认因果关系并评估临床疗效。

{"title":"Beyond binary comparisons: A Bayesian dose-response meta-analysis of adherence to the planetary health diet and risks of all-cause mortality and cardiovascular outcomes in adults.","authors":"Khuc Thi Hong Hanh, Tran Quang Duc, Nguyen Di Khanh, Dang Dang Khoa, Nguyen Thi Hoa Huyen, Nguyen Huynh Phuong Anh","doi":"10.1016/j.ypmed.2026.108551","DOIUrl":"https://doi.org/10.1016/j.ypmed.2026.108551","url":null,"abstract":"<p><strong>Objectives: </strong>The Planetary Health Diet (PHD) is associated with lower mortality and cardiovascular disease (CVD) risk, but evidence on specific CVD subtypes and risk patterns across the full range of adherence remains limited. To assess associations between PHD adherence and all-cause mortality, cardiovascular mortality, and CVDs, and to evaluate dose-response relationships.</p><p><strong>Methods: </strong>We searched four databases from inception to January 2026 for prospective cohort studies in adults. Hazard ratios were pooled using random-effects models for highest vs. lowest adherence. Bayesian hierarchical dose-response models with centered RIDIT scores assessed graded associations. Study quality and evidence certainty were evaluated using the Newcastle-Ottawa Scale and NutriGrade.</p><p><strong>Results: </strong>23 studies were included. Highest adherence was associated with reduced risk of all-cause mortality (17%), cardiovascular mortality (16%), and total CVDs (18%). Dose-response analyses revealed risk reductions beginning at quintile 3 for all-cause mortality and total CVDs, and at quintile 4 for cardiovascular mortality. Highest adherence was associated with lower risks of coronary heart disease, ischemic heart disease, heart failure, and atrial fibrillation, but not myocardial infarction. Most studies were of high quality; the meta-evidence ranged from moderate to high.</p><p><strong>Conclusions: </strong>Randomized trials are needed to confirm causality and assess clinical effectiveness.</p>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":" ","pages":"108551"},"PeriodicalIF":3.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147491838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward cervical cancer prevention and elimination in the Eastern Mediterranean Region: Current landscape and opportunities for evidence-based action. 东地中海区域预防和消除宫颈癌：现状和循证行动的机会。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-03-16 DOI: 10.1016/j.ypmed.2026.108549

Mariam El-Zein, Pareesa Kassam, Fatimah Alhamlan, Noreen Zafar, Balkiss Abdelmoula, Ibtihal Fadhil, Belinda Nedjai, Farida Selmouni, Partha Basu

Objective: This review aimed to provide the first comprehensive assessment of cervical cancer prevention initiatives across the Eastern Mediterranean Region (EMR).

Methods: We systematically searched PubMed on March 20, 2025, screened relevant literature, supplemented findings with WHO and HPV Information Centre data, and extracted country-level information on HPV vaccination and cervical cancer screening policies and practices in the EMR.

Results: Of 22 member countries, only eight have national HPV vaccination programs, and just seven offer cervical cancer screening, all of which are opportunistic and based on cytology, an obsolete technology. Barriers include limited public awareness, inadequate engagement of healthcare providers, and underdeveloped healthcare infrastructure. The review also highlights promising innovations such as HPV self-sampling to enhance screening accessibility and feasibility, and DNA methylation markers to improve detection accuracy and risk stratification.

Conclusions: Cervical cancer prevention initiatives across the EMR remains insufficient. This review emphasizes the need for greater coordinated efforts to address the growing burden of cervical cancer in the region, strengthen prevention efforts, and enhance healthcare infrastructure. Bridging these gaps requires strengthened systems, expanded access, and multi-stakeholder advocacy and coordinated policies to reduce the region's cervical cancer burden.

目的：本综述旨在对整个东地中海地区（EMR）的宫颈癌预防措施进行首次全面评估。方法：系统检索2025年3月20日的PubMed，筛选相关文献，用WHO和HPV信息中心的数据补充研究结果，提取EMR中HPV疫苗接种和宫颈癌筛查政策和实践的国家级信息。结果：在22个成员国中，只有8个有国家HPV疫苗接种计划，只有7个提供宫颈癌筛查，所有这些都是机会性的，基于细胞学，这是一种过时的技术。障碍包括公众意识有限、卫生保健提供者参与不足以及卫生保健基础设施不发达。该综述还强调了有前途的创新，如HPV自采样，以提高筛查的可及性和可行性，以及DNA甲基化标记，以提高检测准确性和风险分层。结论：整个EMR的宫颈癌预防措施仍然不足。该审查强调需要更大的协调努力，以解决该地区宫颈癌日益增加的负担，加强预防工作，并加强保健基础设施。弥合这些差距需要加强系统、扩大可及性、多方利益攸关方宣传和协调政策，以减少该区域的宫颈癌负担。

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引用次数: 0

Optimizing exercise prescription for blood pressure control after stroke or transient ischemic attack: A systematic review and meta-analysis. 优化运动处方控制中风或短暂性脑缺血发作后的血压：一项系统综述和荟萃分析。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-03-14 DOI: 10.1016/j.ypmed.2026.108550

Yifan Zhang, Hao Huang, Zhiyuan Tan, Lingzi Lei, Xueying Chen

Objective: This study aimed to examine the dose-response relationships between different exercise modalities and blood pressure reduction in individuals after stroke or transient ischemic attack METHODS: Searches were performed in PubMed (1946), Web of Science (1975), Cochrane CENTRAL (1992), and EMBASE (1971) from inception up to December 10, 2025. Exercise dose was calculated as the product of duration, frequency, and intensity, expressed in metabolic equivalents of task minutes per week (METs-min/week).

Results: A total of 25 studies were included in the review. Aerobic exercise produced the greatest reductions in systolic blood pressure (SBP) at 590 METs-min/week (-3.79 mmHg, 95% CrI: -5.95, -1.86) and diastolic blood pressure (DBP) at 520 METs-min/week (-1.91 mmHg, 95% CrI: -3.56, -0.33). For combined aerobic and resistance training, the optimal doses were 780 METs-min/week for SBP (-7 mmHg, 95% CrI: -10.05, -3.87) and 660 METs-min/week for DBP (-3.58 mmHg, 95% CrI: -6.04, -1.23). Relative ranking analyses indicated that combined aerobic and resistance training at 780 METs-min/week and 660 METs-min/week produced the greatest reductions in SBP and DBP, respectively.

Conclusions: These findings support evidence-based exercise prescriptions for blood pressure management in this high-risk population.

目的：本研究旨在探讨不同运动方式与中风或短暂性脑缺血发作后个体血压降低之间的剂量-反应关系。方法：检索PubMed（1946）、Web of Science（1975）、Cochrane CENTRAL（1992）和EMBASE(1971)，检索时间从开始到2025年12月10日。运动剂量以持续时间、频率和强度的乘积计算，以每周任务分钟的代谢当量（METs-min/week）表示。结果：共纳入25项研究。有氧运动最大程度降低收缩压（SBP）为590 METs-min/周（-3.79 mmHg, 95% CrI: -5.95, -1.86），舒张压（DBP）为520 METs-min/周（-1.91 mmHg, 95% CrI: -3.56, -0.33）。对于有氧和阻力联合训练，最佳剂量为收缩压780 METs-min/周（-7 mmHg, 95% CrI: -10.05, -3.87）和舒张压660 METs-min/周（-3.58 mmHg, 95% CrI: -6.04, -1.23）。相对排名分析表明，780 METs-min/周和660 METs-min/周的有氧和阻力联合训练分别能最大程度地降低收缩压和舒张压。结论：这些发现支持以证据为基础的运动处方对高危人群进行血压管理。

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引用次数: 0

Psychosocial factors can shape the use of preventive healthcare services. 心理社会因素可以影响预防性保健服务的使用。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-03-11 DOI: 10.1016/j.ypmed.2026.108548

André Hajek, Hans-Helmut König

引用次数: 0

The impact of frequent interruptions to sedentary behavior on postprandial metabolism in healthy adults: A systematic review and meta-analysis of randomized controlled trials 频繁中断久坐行为对健康成人餐后代谢的影响：随机对照试验的系统回顾和荟萃分析

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1016/j.ypmed.2026.108517

Yuli Zhang , Zhenghui Zha , Cuiyun Tian , Dongxiang Huang , Tuming Shen , Jingbin Liu , Songtao Wang

Objectives

To evaluate the effects of interrupting sedentary behavior on postprandial metabolic outcomes in healthy adults.

Methods

We systematically searched seven databases (PubMed, Embase, Scopus, Cochrane, Web of Science, SPORTDiscus, and CINAHL Complete) from inception to June 6, 2025, for eligible randomized controlled trials. Primary outcomes included total and incremental areas under the curve for glucose, insulin, and triglycerides. Study quality (Cochrane Risk of Bias version 2) and overall evidence quality (Grading of Recommendations, Assessment, Development, and Evaluations) were assessed. Data were pooled using random-effects meta-analysis in Stata 18.0, with effects expressed as standardized mean difference (SMD) and 95% confidence interval (95% CI).

Results

Seventeen randomized controlled trials comprising 337 healthy adults were included. Meta-analysis showed that interrupting sedentary behavior significantly reduced glucose incremental area under the curve (SMD = −0.35; 95% CI: −0.56, −0.15) and insulin incremental area under the curve (SMD = −0.37; 95% CI: −0.56, −0.18), but had no significant effect on total area under the curve for glucose, insulin, and triglycerides, nor on the incremental area for triglycerides.

Conclusions

Interrupting sedentary behavior improves postprandial metabolism by specifically reducing the spike in blood glucose and insulin after a meal, without affecting overall metabolic exposure or lipid levels.

目的：评估中断久坐行为对健康成人餐后代谢结果的影响。方法：从研究开始到2025年6月6日，我们系统地检索了7个数据库（PubMed、Embase、Scopus、Cochrane、Web of Science、SPORTDiscus和CINAHL Complete），以获得符合条件的随机对照试验。主要结局包括葡萄糖、胰岛素和甘油三酯曲线下的总面积和增量面积。评估了研究质量（Cochrane Risk of Bias version 2）和总体证据质量（分级推荐、评估、发展和评价）。在Stata 18.0中使用随机效应荟萃分析合并数据，效应用标准化平均差（SMD）和95%置信区间（95% CI）表示。结果：纳入17项随机对照试验，包括337名健康成人。荟萃分析显示，中断久坐行为可显著降低葡萄糖曲线下增量面积（SMD = -0.35;95% CI: -0.56, -0.15）和胰岛素曲线下增量面积（SMD = -0.37;95% CI: -0.56, -0.18），但对葡萄糖、胰岛素和甘油三酯的曲线下总面积无显著影响，对甘油三酯的曲线下增量面积也无显著影响。结论：通过降低餐后血糖和胰岛素的峰值，打断久坐行为可以改善餐后代谢，而不会影响整体代谢暴露或脂质水平。

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引用次数: 0