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Firearm possession among emergency department youth and young adults: A latent class analysis.
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-23 DOI: 10.1016/j.ypmed.2024.108183
Heather A Hartman, Laura A Seewald, Philip Stallworth, Daniel B Lee, Marc A Zimmerman, Peter F Ehrlich, Maureen A Walton, Kenneth Resnicow, Patrick M Carter

Introduction: Firearm injuries are a leading cause of death for youth/young-adults. We utilized latent class analysis to identify distinct motivational/behavioral patterns of firearm possession in a youth/young-adult emergency department sample to inform prevention strategies.

Methods: Cross-sectional data were obtained from surveys conducted among youth/young-adults (age = 16-29; n = 1311) seeking emergency department treatment (7/10/2017-6/25/2018). Latent class analysis was performed for individuals reporting firearm possession (n = 223) using five variables: carriage frequency, social carriage, risky firearm behaviors, ownership/carriage for protection, and recreational ownership/carriage. Descriptive statistics were examined.

Results: In this sample, 17.0 % reported having firearms (age-22.7; 48.0 %-male; 49.3 %-Black; 52.5 %-public assistance). Latent class analysis identified four classes: 1-recreational possession (n = 51); 2-possession for protection with low carriage (n = 60); 3-carriage for protection with low risky firearm behaviors (n = 76); and 4-carriage for protection with high risky firearm behaviors (n = 36). Class-1 (recreational possession) had low firearm victimization, violence exposure, and community violence. This class primarily kept long-guns with secure storage patterns. Class-2 (protection with low carriage) were mostly female youth/young-adults with children and reported moderately high rates of violence exposure. Nearly 20 % stored their firearm unlocked. Class-3 and -4 endorsed firearm carriage for protection, with Class-4 also engaging in risky firearm behaviors. Both classes had high violence exposure; however, Class-4 had higher risk profiles including higher marijuana misuse, mental health symptoms, and firearm victimization.

Conclusions: Among an emergency department sample, four distinct firearm possession classes emerged with different risk levels. Understanding firearm behaviors and risk/protective factors is critical to tailoring healthcare-focused interventions to address individual needs and reduce injury risk.

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引用次数: 0
Health-related social needs screening, reporting, and assistance in a large health system.
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-23 DOI: 10.1016/j.ypmed.2024.108182
Elyse N Llamocca, Andrew S Bossick, Denise White Perkins, Brian K Ahmedani, Rob Behrendt, Anna Bloemen, Angela Murphy, Aishwarya Kulkarni, Elizabeth Lockhart

Background: National mandates require screening for and addressing health-related social needs (HRSNs) in healthcare settings. However, differences in HRSN screening process (i.e., completed screenings, screening results, documented offer of assistance, documented assistance request) have been reported by population subgroup. Knowledge of the most effective HRSN screening and intervention methods is limited. We sought to describe differences in completed HRSN screenings, screening results, and assistance request rates across patient and healthcare visit characteristics.

Methods: We examined data from all patients aged ≥18 years and residing in the US receiving services at a large, Midwestern healthcare system with a goal to screen all patients for HRSN at least once annually between July 2021-June 2023 (n = 1,190,488). We examined the proportion of patients with any HRSN screening, with any reported HRSN, asked whether they wanted assistance, or who requested assistance for a reported HRSN stratified by patient demographics and healthcare visit characteristics (i.e., payer, screening location, who completed the screening).

Results: Less than half of eligible patients (47.0 %) were screened for HRSNs. About one-sixth (16.9 %) reported any HRSN. Although most patients reporting HRSNs were asked whether they wanted assistance, only about one-quarter (26.8 %) responded affirmatively. Proportions included in each step of the HRSN screening process significantly differed by patient and healthcare visit characteristics.

Discussion: This study is one of the first to investigate various steps of a population-wide HRSN screening program. Our findings suggest that examining differences in HRSN screening process by population subgroup is key to addressing HRSNs through a health equity lens.

背景:国家规定要求在医疗机构中筛查并解决与健康相关的社会需求(HRSN)。然而,根据人口亚群的不同,HRSN 筛查过程(即已完成的筛查、筛查结果、记录在案的援助提议、记录在案的援助请求)也存在差异。有关最有效的 HRSN 筛查和干预方法的知识还很有限。我们试图描述不同患者和医疗就诊特征在完成 HRSN 筛查、筛查结果和援助请求率方面的差异:我们研究了在美国中西部一家大型医疗保健系统接受服务的所有年龄≥18 岁的患者的数据,该系统的目标是在 2021 年 7 月至 2023 年 6 月期间每年至少对所有患者进行一次 HRSN 筛查(n = 1,190,488)。我们根据患者人口统计学特征和医疗就诊特征(即付款方、筛查地点、完成筛查者),研究了接受过任何 HRSN 筛查、报告过任何 HRSN、被问及是否需要援助或因报告 HRSN 而请求援助的患者比例:不到一半的合格患者(47.0%)接受了 HRSN 筛查。约六分之一(16.9%)的患者报告了任何 HRSN。尽管大多数报告有 HRSN 的患者都被问及是否需要帮助,但只有约四分之一(26.8%)的患者做出了肯定的回答。HRSN筛查过程中每个步骤所包含的比例因患者和就诊特征的不同而存在显著差异:本研究是首次调查全人群 HRSN 筛查计划各个步骤的研究之一。我们的研究结果表明,研究不同人口亚群在 HRSN 筛查过程中的差异是通过健康公平视角解决 HRSN 问题的关键。
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引用次数: 0
Heart failure and cardiomyopathy mortality trends and disparities among obese populations: A 20-year United States study 肥胖人群中心力衰竭和心肌病的死亡率趋势和差异:一项为期 20 年的美国研究。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-17 DOI: 10.1016/j.ypmed.2024.108179
Yong-Hao Yeo , Boon-Jian San , Ela Ahmad , Min-Choon Tan , Yuh-Miin Sin , Milena Jani , Richard J. Bloomingdale

Objective

Our study aimed to assess the heart failure/cardiomyopathy-related population-level mortality trends among patients with obesity in the United States and disparities across demographics.

Methods

We queried the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database among adults aged ≥25 from 1999 to 2019. Heart failure/cardiomyopathy were listed as the main causes of death, with obesity as a contributing cause. We calculated age-adjusted mortality rates (AAMR) per 100,000 individuals and estimated the average annual percent change (AAPC). We also evaluated the social vulnerability of United States counties (2014–2018).

Results

There were 29,334 deaths related to heart failure/cardiomyopathy among patients with comorbid obesity. The overall AAMR increased from 0.41 in 1999 to 0.94 in 2019, with an AAPC of 3.78 (95 % CI, 3.41–4.14). The crude mortality rate increase for heart failure/cardiomyopathy was greater in individuals with comorbid obesity than in those without. Males had a higher AAMR than females (0.78 vs 0.55). African Americans also had higher AAMR than Whites (1.35 vs 0.62). The AAMR was higher in rural areas than in urban regions (0.76 vs 0.66). The overall AAMR was higher in counties with social vulnerability index-Quartile 4 (SVI-Q4) (most vulnerable) (1.08) compared to SVI-Q1 (least vulnerable) (0.63) with a risk ratio of 1.71 (95 % CI: 1.61–1.83).

Conclusion

Heart failure/cardiomyopathy mortality in individuals with comorbid obesity was rising. Males, African Americans, and individuals from rural regions had higher AAMR than their counterparts.
研究目的我们的研究旨在评估美国肥胖患者中与心衰/心肌病相关的人群死亡率趋势以及不同人口统计学之间的差异:我们查询了美国疾病控制和预防中心的广泛流行病学研究在线数据数据库,其中包含 1999 年至 2019 年年龄≥25 岁的成年人。心力衰竭/心肌病被列为主要死因,肥胖也是一个诱因。我们计算了每 10 万人的年龄调整死亡率 (AAMR),并估算了年均百分比变化 (AAPC)。我们还评估了美国各县的社会脆弱性(2014-2018 年):结果:在合并肥胖症的患者中,有29334人死于心力衰竭/心肌病。总体AAMR从1999年的0.41上升至2019年的0.94,AAPC为3.78(95 % CI,3.41-4.14)。合并肥胖者的心力衰竭/心肌病粗死亡率增幅大于未合并肥胖者。男性的 AAMR 比女性高(0.78 对 0.55)。非裔美国人的 AAMR 也高于白人(1.35 对 0.62)。农村地区的急性心肌梗死死亡率高于城市地区(0.76 对 0.66)。社会脆弱指数四分位数(SVI-Q4)(最脆弱)县的总体急性心力衰竭死亡率(1.08)高于 SVI-Q1(最不脆弱)县(0.63),风险比为 1.71(95 % CI:1.61-1.83):结论:合并肥胖症的心力衰竭/心肌病患者死亡率呈上升趋势。男性、非裔美国人和来自农村地区的人的AAMR高于同类人群。
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引用次数: 0
Comparative effectiveness of high-efficacy and moderate efficacy disease-modifying agents in reducing the annualized relapse rates among multiple sclerosis patients in the United States 高效和中效改变病情药物在降低美国多发性硬化症患者年复发率方面的疗效比较。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-16 DOI: 10.1016/j.ypmed.2024.108180
Jieni Li , George J. Hutton , Tyler J. Varisco , Ying Lin , Ekere J. Essien , Rajender R. Aparasu

Objective

The optimal treatment strategy for the management of multiple sclerosis is widely discussed due to the increasing availability of high-efficacy disease-modifying agents (heDMAs). This study evaluated the comparative effectiveness of heDMA and moderate-efficacy disease-modifying agents (meDMAs) use in reducing annualized relapse rate (ARR) among multiple sclerosis patients.

Methods

A retrospective cohort study was conducted using the 2015–2019 United States Merative MarketScan Commercial Claims Data. Adult (18–64 years) patients with incident disease-modifying agents (DMA) use were included. Claim-based relapse algorithms were applied to measure relapse events. The inverse probability treatment weighting (IPTW) based negative binomial regression model with the offset of the follow-up period was used to compare the ARR. The moderation effect of sex on ARR was also examined.

Results

This study included 10,003 incident DMA users, with 22.9 % initiated heDMAs. The average ARR during follow-up among heDMA users was lower than meDMA users (0.25 vs. 0.28, p < 0.01). The IPTW-based regression found that sex moderated the relationship between the types of DMAs and ARR. Stratified analyses revealed that heDMAs were associated with a lower ARR in males (adjusted incidence rate ratio [aIRR] 0.74; 95 % confidence interval [CI] 0.59–0.94) compared with meDMAs. No significant differences were noted among females (aIRR 0.99; 95 % CI: 0.88–1.21).

Conclusion

The study found that sex moderated the effect of heDMAs, with male multiple sclerosis patients using heDMAs associated with a 26 % decreased risk of relapse than those with meDMAs. However, there was no difference in comparative effectiveness for females.
目的:由于高效改变病情药物(heDMAs)的供应量不断增加,治疗多发性硬化症的最佳治疗策略引起了广泛讨论。本研究评估了heDMA和中等疗效疾病修饰药物(meDMA)在降低多发性硬化症患者年复发率(ARR)方面的疗效比较:利用 2015-2019 年美国 Merative MarketScan 商业索赔数据开展了一项回顾性队列研究。研究纳入了使用改变病情药物(DMA)的成人(18-64 岁)患者。采用基于索赔的复发算法来衡量复发事件。采用基于反概率治疗加权(IPTW)的负二项回归模型,并抵消随访期来比较 ARR。研究还考察了性别对 ARR 的调节作用:本研究共纳入 10,003 名 DMA 使用者,其中 22.9% 开始使用 heDMA。在随访期间,heDMA 使用者的平均 ARR 低于 meDMA 使用者(0.25 vs. 0.28,p 结论:研究发现,性别对 ARR 有调节作用:研究发现,性别对heDMAs的影响具有调节作用,使用heDMAs的男性多发性硬化症患者的复发风险比使用meDMAs的患者降低了26%。不过,女性患者的疗效比较没有差异。
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引用次数: 0
Sex-specific associations of cigarettes and E-cigarettes use with self-reported premature atherosclerotic cardiovascular disease among adults aged 18-54 in the United States. 美国 18-54 岁成年人中香烟和电子烟使用与自我报告的过早发生动脉粥样硬化性心血管疾病的性别特异性关联。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-16 DOI: 10.1016/j.ypmed.2024.108181
Ememgini Elo-Eghosa, Wei Li, Mohammad Ebrahimi Kalan, Nan Hu, Olatokunbo Osibogun

Background: Premature atherosclerotic cardiovascular disease (ASCVD) is increasing in young adults (<55 years old). While research suggests females who smoke cigarettes have a higher risk of ASCVD than males, studies on the impact of exclusive e-cigarette and dual use on premature ASCVD are limited. This study investigated the association between tobacco use and self-reported premature ASCVD and explored potential sex differences.

Methods: Using pooled data from 480,317 adults (ages 18-54; ~50 % female) from the 2020-2022 Behavioral Risk Factor Surveillance System from the United States, logistic regression models assessed associations between cigarette and e-cigarette use patterns and self-reported premature ASCVD. Tobacco use categories were defined as: non-use, former use (cigarettes, e-cigarettes), and current use (cigarettes, e-cigarettes) and dual use. Self-reported premature ASCVD was defined as self-reported angina or coronary heart disease, heart attack, or stroke. Weighted analyses were conducted for the overall sample and stratified by sex.

Results: After controlling for potential confounders, former exclusive cigarette (adjusted OR: 1.47 [95 % CI 1.29, 1.67]), current exclusive cigarette (1.68 [1.47-1.94]) and current dual (2.03 [1.69-2.44]) use were associated with higher odds of self-reported premature ASCVD. There was no significant association for e-cigarette use. Sex-specific analyses revealed similar patterns but the magnitude of these associations varied between males and females.

Conclusion: Both sexes showed higher odds of self-reported premature ASCVD for dual and exclusive cigarette use. Although the cross-sectional design precludes causal inferences, the findings suggest comprehensive tobacco cessation programs tailored to diverse use patterns are needed to reduce the burden of premature ASCVD.

背景:早发动脉粥样硬化性心血管疾病(ASCVD)在年轻成年人中呈上升趋势(方法:利用来自美国 2020-2022 年行为风险因素监测系统的 480,317 名成人(18-54 岁;约 50% 为女性)的汇总数据,逻辑回归模型评估了香烟和电子烟使用模式与自我报告的过早发生 ASCVD 之间的关联。烟草使用类别定义为:不使用、曾经使用(香烟、电子烟)、当前使用(香烟、电子烟)和双重使用。自我报告的过早发生 ASCVD 定义为自我报告的心绞痛或冠心病、心脏病发作或中风。对总体样本进行了加权分析,并按性别进行了分层:在控制了潜在的混杂因素后,以前只吸烟(调整后 OR:1.47 [95 % CI 1.29,1.67])、现在只吸烟(1.68 [1.47-1.94])和现在双重吸烟(2.03 [1.69-2.44])与自我报告的过早发生 ASCVD 的几率较高有关。电子烟的使用与此无明显关联。性别特异性分析显示了类似的模式,但男性和女性之间的关联程度有所不同:结论:对于双重吸烟和完全吸烟的人群,男女自我报告的过早发生 ASCVD 的几率都较高。尽管横断面设计排除了因果推论,但研究结果表明,需要针对不同的使用模式制定全面的戒烟计划,以减轻过早发生 ASCVD 的负担。
{"title":"Sex-specific associations of cigarettes and E-cigarettes use with self-reported premature atherosclerotic cardiovascular disease among adults aged 18-54 in the United States.","authors":"Ememgini Elo-Eghosa, Wei Li, Mohammad Ebrahimi Kalan, Nan Hu, Olatokunbo Osibogun","doi":"10.1016/j.ypmed.2024.108181","DOIUrl":"10.1016/j.ypmed.2024.108181","url":null,"abstract":"<p><strong>Background: </strong>Premature atherosclerotic cardiovascular disease (ASCVD) is increasing in young adults (<55 years old). While research suggests females who smoke cigarettes have a higher risk of ASCVD than males, studies on the impact of exclusive e-cigarette and dual use on premature ASCVD are limited. This study investigated the association between tobacco use and self-reported premature ASCVD and explored potential sex differences.</p><p><strong>Methods: </strong>Using pooled data from 480,317 adults (ages 18-54; ~50 % female) from the 2020-2022 Behavioral Risk Factor Surveillance System from the United States, logistic regression models assessed associations between cigarette and e-cigarette use patterns and self-reported premature ASCVD. Tobacco use categories were defined as: non-use, former use (cigarettes, e-cigarettes), and current use (cigarettes, e-cigarettes) and dual use. Self-reported premature ASCVD was defined as self-reported angina or coronary heart disease, heart attack, or stroke. Weighted analyses were conducted for the overall sample and stratified by sex.</p><p><strong>Results: </strong>After controlling for potential confounders, former exclusive cigarette (adjusted OR: 1.47 [95 % CI 1.29, 1.67]), current exclusive cigarette (1.68 [1.47-1.94]) and current dual (2.03 [1.69-2.44]) use were associated with higher odds of self-reported premature ASCVD. There was no significant association for e-cigarette use. Sex-specific analyses revealed similar patterns but the magnitude of these associations varied between males and females.</p><p><strong>Conclusion: </strong>Both sexes showed higher odds of self-reported premature ASCVD for dual and exclusive cigarette use. Although the cross-sectional design precludes causal inferences, the findings suggest comprehensive tobacco cessation programs tailored to diverse use patterns are needed to reduce the burden of premature ASCVD.</p>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":" ","pages":"108181"},"PeriodicalIF":4.3,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of vaping with respiratory symptoms in U.S. young adults: Nicotine, cannabis, and dual vaping 美国年轻人吸烟与呼吸道症状的关系:尼古丁、大麻和双重吸食。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-14 DOI: 10.1016/j.ypmed.2024.108175
Ruoyan Sun , Gabriela R. Oates

Introduction

Although studies have found nicotine and cannabis vaping to be individually associated with respiratory symptoms, little is known about the harm of dual vaping. We aim to assess the association of nicotine-only, cannabis-only, and dual vaping with respiratory symptoms.

Methods

Using a national sample of 8033 U.S. young adults (ages 18–24) interviewed in 2021, we employed multivariable logistic regressions to assess the association between vaping behaviors and past 12-month respiratory outcomes.

Results

Of all participants, 75.4 % did not vape, 15.0 % vaped nicotine only, 4.7 % vaped cannabis only, and 4.9 % vaped both. Compared with no vaping, nicotine-only vaping was associated with sounding wheezy (aPR = 1.75, 95 % CI, 1.28–2.39) and dry cough at night (aPR = 1.43, 95 % CI, 1.19–1.72). Cannabis-only vaping was also associated with these two symptoms, with aPRs at 1.82 (95 % CI, 1.15–2.88) and 1.61 (95 % CI, 1.18–2.21), respectively. In addition to these two symptoms (aPR = 2.24, 95 % CI, 1.42–3.54 for sounding wheezy, and aPR = 1.50, 95 % CI, 1.01–2.22 for dry cough at night), dual vaping was associated with wheezing or whistling (aPR = 1.93, 95 % CI, 1.23–3.04) and high level of respiratory symptoms (aPR = 2.02, 95 % CI, 1.24–3.32). Compared with non-frequent vaping, cannabis-only and dual frequent vaping were associated with higher risks of wheezing or whistling.

Conclusions

Nicotine-only and cannabis-only vaping were associated with two respiratory symptoms while dual vaping with four. The elevated respiratory risk of dual vaping warrants future research on the underlying mechanisms of different vaping behaviors and respiratory outcomes.
导言:尽管研究发现尼古丁和大麻吸食分别与呼吸道症状有关,但对双重吸食的危害却知之甚少。我们的目的是评估只吸食尼古丁、只吸食大麻和双重吸食与呼吸道症状的关系:我们在 2021 年对 8033 名美国年轻成年人(18-24 岁)进行了全国性抽样调查,采用多变量逻辑回归评估了吸食行为与过去 12 个月呼吸系统结果之间的关联:在所有参与者中,75.4% 不吸食,15.0% 只吸食尼古丁,4.7% 只吸食大麻,4.9% 两者都吸食。与不吸食相比,只吸食尼古丁与夜间喘息(aPR = 1.75,95 % CI,1.28-2.39)和干咳(aPR = 1.43,95 % CI,1.19-1.72)有关。只吸食大麻也与这两种症状有关,aPR 分别为 1.82(95 % CI,1.15-2.88)和 1.61(95 % CI,1.18-2.21)。除了这两种症状(喘息声的 aPR = 2.24,95 % CI,1.42-3.54;夜间干咳的 aPR = 1.50,95 % CI,1.01-2.22)外,双重吸烟还与喘息或啸叫(aPR = 1.93,95 % CI,1.23-3.04)和高度呼吸道症状(aPR = 2.02,95 % CI,1.24-3.32)有关。与不经常吸食相比,只吸食大麻和双重频繁吸食与较高的喘息或吹口哨风险相关:结论:只吸食尼古丁和只吸食大麻与两种呼吸道症状有关,而双重吸食则与四种呼吸道症状有关。双重吸食者的呼吸系统风险升高,需要在未来对不同吸食行为和呼吸系统结果的内在机制进行研究。
{"title":"Association of vaping with respiratory symptoms in U.S. young adults: Nicotine, cannabis, and dual vaping","authors":"Ruoyan Sun ,&nbsp;Gabriela R. Oates","doi":"10.1016/j.ypmed.2024.108175","DOIUrl":"10.1016/j.ypmed.2024.108175","url":null,"abstract":"<div><h3>Introduction</h3><div>Although studies have found nicotine and cannabis vaping to be individually associated with respiratory symptoms, little is known about the harm of dual vaping. We aim to assess the association of nicotine-only, cannabis-only, and dual vaping with respiratory symptoms.</div></div><div><h3>Methods</h3><div>Using a national sample of 8033 U.S. young adults (ages 18–24) interviewed in 2021, we employed multivariable logistic regressions to assess the association between vaping behaviors and past 12-month respiratory outcomes.</div></div><div><h3>Results</h3><div>Of all participants, 75.4 % did not vape, 15.0 % vaped nicotine only, 4.7 % vaped cannabis only, and 4.9 % vaped both. Compared with no vaping, nicotine-only vaping was associated with sounding wheezy (aPR = 1.75, 95 % CI, 1.28–2.39) and dry cough at night (aPR = 1.43, 95 % CI, 1.19–1.72). Cannabis-only vaping was also associated with these two symptoms, with aPRs at 1.82 (95 % CI, 1.15–2.88) and 1.61 (95 % CI, 1.18–2.21), respectively. In addition to these two symptoms (aPR = 2.24, 95 % CI, 1.42–3.54 for sounding wheezy, and aPR = 1.50, 95 % CI, 1.01–2.22 for dry cough at night), dual vaping was associated with wheezing or whistling (aPR = 1.93, 95 % CI, 1.23–3.04) and high level of respiratory symptoms (aPR = 2.02, 95 % CI, 1.24–3.32). Compared with non-frequent vaping, cannabis-only and dual frequent vaping were associated with higher risks of wheezing or whistling.</div></div><div><h3>Conclusions</h3><div>Nicotine-only and cannabis-only vaping were associated with two respiratory symptoms while dual vaping with four. The elevated respiratory risk of dual vaping warrants future research on the underlying mechanisms of different vaping behaviors and respiratory outcomes.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108175"},"PeriodicalIF":4.3,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clearing the air: Heightened perception of harm from secondhand cannabis smoke exposure is associated with no in-home cannabis smoking in a 21-country convenience sample. 净化空气:在 21 个国家的便利抽样调查中,对二手大麻烟雾危害的高度认识与不在家中吸食大麻有关。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-14 DOI: 10.1016/j.ypmed.2024.108178
Osika Tripathi, Humberto Parada, Sandy Liles, Yuyan Shi, Georg E Matt, Penelope J E Quintana, Jason Ferris, Adam Winstock, John Bellettiere

Objective: As countries adopt more lenient cannabis use policies, perception of harm from secondhand cannabis smoke (SHCS) exposure is decreasing and most cannabis smoking is taking place at home. We quantified the relationship of reported in-home cannabis smoking with perceived harm from SHCS exposure.

Methods: The analytic sample comprised 28,154 adult respondents, from 21 countries, to the annual cross-sectional Global Drug Survey (2021) of users of licit or illicit drugs. Respondents reported perception of harm to non-smoking residents from SHCS exposure and past 30-day cannabis smoking in the home by anyone. Logistic regression estimated covariate-adjusted odds ratios and 95 % confidence intervals of in-home cannabis smoking (yes/no). The association between harm perception and in-home cannabis smoking by country of residence was also quantified.

Results: Sixty-one percent reported no in-home cannabis smoking in the last 30 days; mean perception of harm of SHCS exposure on a 10-point scale was 5.2. Those at the 75th (vs 25th) percentile of perceived harm had 70 % higher odds (OR = 1.7, 95 % CI = 1.6-1.8) of no in-home cannabis smoking. In all countries of residence, higher perception of harm was associated with reporting no in-home cannabis smoking, although not all were statistically significant. The strongest association was seen in Sweden (OR = 3.9, 95 % CI = 1.5-11.9) and New Zealand (OR = 2.3, 95 % CI = 2.0-2.7).

Conclusions: Respondents who perceived SHCS as harmful were less likely to report in-home cannabis smoking. If this association subsequently proves causal, increasing awareness of the harms associated with SHCS exposure could substantially reduce residential cannabis secondhand smoke exposure.

目的:随着各国采取更加宽松的大麻使用政策,人们对二手大麻烟雾(SHCS)暴露危害的认识正在下降,而且大多数大麻吸烟都是在家中进行的。我们量化了所报告的在家吸食大麻与二手大麻烟雾(SHCS)暴露危害感知之间的关系:分析样本包括来自 21 个国家的 28,154 名成年受访者,他们是年度横截面全球药物调查(2021 年)的合法或非法药物使用者。受访者报告了对暴露于 SHCS 对非吸烟居民造成危害的感知,以及过去 30 天内任何人在家中吸食大麻的情况。逻辑回归估算了经协变因素调整的家庭内吸食大麻(是/否)的几率比和 95 % 置信区间。此外,还按居住国量化了危害感知与在家中吸食大麻之间的关联:61%的人报告在过去 30 天内没有在家中吸食大麻;按 10 分制计算,对接触 SHCS 危害的平均感知为 5.2。危害感知处于第 75 百分位数(与第 25 百分位数相比)的人不在家中吸食大麻的几率要高出 70%(OR = 1.7,95 % CI = 1.6-1.8)。在所有居住国中,对危害感知较高的人报告未在家中吸食大麻的几率较高,但并非所有国家都具有显著的统计学意义。瑞典(OR = 3.9,95 % CI = 1.5-11.9)和新西兰(OR = 2.3,95 % CI = 2.0-2.7)的相关性最强:认为吸食大麻有害的受访者在家中吸食大麻的可能性较低。如果这种关联随后被证明是因果关系,那么提高对吸入有害健康物质相关危害的认识将大大减少住宅中的大麻二手烟暴露。
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引用次数: 0
Human papillomavirus-associated cancers, precancers, and genital warts in Denmark, 2000–2022 – Current burden of disease and population impact of multi-cohort HPV vaccination 2000-2022 年丹麦与人类乳头瘤病毒相关的癌症、癌前病变和生殖器疣 - 当前疾病负担和多队列人类乳头瘤病毒疫苗接种对人口的影响。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-10 DOI: 10.1016/j.ypmed.2024.108165
Emma L. Kaderly Rasmussen , Sofie Lindquist , Louise Baandrup , Tatiana Hansen , Christian Munk , Kirsten Frederiksen , Susanne K. Kjær

Objectives

We present incidence trends of cancer and precancer at human papillomavirus(HPV)-associated sites, and genital warts, including the current burden of HPV-associated disease in Denmark, a country with multi-cohort HPV vaccination.

Method

Cases were identified from high-quality nationwide registries (2000−2022). The age-specific incidence rate, age-standardized incidence rate (ASR) and estimated annual percentage change (EAPC) were calculated according to sex and calendar year. The current burden (2020−2022) of HPV-associated disease was estimated as the average annual number of each lesion multiplied by the disease-specific HPV-attributable fraction.

Results

ASRs of cervical precancer and genital warts declined markedly in the post-HPV vaccination period – for genital warts corresponding to an EAPC of −13.7 % (−15.0;−12.4)(women) and −8.8 % (−9.4;−8.2)(men), respectively. ASRs of HPV-associated cancer sites increased continuously in men (EAPC: 2.8 % (2.2;3.5)), and the same was observed for non-cervical HPV-associated cancer sites in women (EAPC: 2.5 % (2.0;3.0)). Cervical cancer, however, decreased in the post-HPV vaccination period (EAPC: −2.7 % (−3.8;−1.5)). Age-specific incidence rates of HPV-associated cancer sites decreased slightly in younger women and were stable in younger men, while incidence rates in older men approached or even surpassed that of older women. Data on the current burden showed that cervical precancer and genital warts are still the major contributors to HPV-associated disease, and oropharyngeal cancer now accounts for more annual cases on a population level than cervical cancer.

Conclusion

Danish data show decreased incidence of cervical lesions and genital warts in the post-vaccine era. Despite population impact of HPV vaccination, HPV-associated disease remains a public health issue and increasingly among men.
目的:我们介绍了人乳头瘤病毒(HPV)相关部位癌症和癌前病变以及生殖器疣的发病趋势,包括丹麦(一个接种多组HPV疫苗的国家)目前HPV相关疾病的负担:方法:从高质量的全国性登记(2000-2022 年)中确定病例。根据性别和日历年计算特定年龄发病率、年龄标准化发病率(ASR)和估计年百分比变化(EAPC)。目前(2020-2022 年)HPV 相关疾病的负担是以每种病变的年平均数量乘以疾病特异性 HPV 可归因部分估算得出的:宫颈癌前病变和生殖器疣的ASR在接种HPV疫苗后明显下降--生殖器疣的EAPC分别为-13.7% (-15.0;-12.4)(女性)和-8.8% (-9.4;-8.2)(男性)。男性 HPV 相关癌症部位的 ASR 持续上升(EAPC:2.8 % (2.2;3.5)),女性非宫颈 HPV 相关癌症部位的 ASR 也是如此(EAPC:2.5 % (2.0;3.0))。不过,宫颈癌的发病率在接种 HPV 疫苗后有所下降(欧洲和中亚地区:-2.7 % (-3.8;-1.5))。HPV相关癌症部位的特定年龄发病率在年轻女性中略有下降,在年轻男性中保持稳定,而老年男性的发病率接近甚至超过了老年女性。有关目前负担的数据显示,宫颈癌前病变和生殖器疣仍然是导致 HPV 相关疾病的主要因素,而口咽癌目前在人群中的年发病率超过了宫颈癌:丹麦的数据显示,在疫苗接种后的时代,宫颈病变和生殖器疣的发病率有所下降。尽管接种人乳头瘤病毒疫苗对人口产生了影响,但人乳头瘤病毒相关疾病仍然是一个公共卫生问题,而且越来越多地发生在男性身上。
{"title":"Human papillomavirus-associated cancers, precancers, and genital warts in Denmark, 2000–2022 – Current burden of disease and population impact of multi-cohort HPV vaccination","authors":"Emma L. Kaderly Rasmussen ,&nbsp;Sofie Lindquist ,&nbsp;Louise Baandrup ,&nbsp;Tatiana Hansen ,&nbsp;Christian Munk ,&nbsp;Kirsten Frederiksen ,&nbsp;Susanne K. Kjær","doi":"10.1016/j.ypmed.2024.108165","DOIUrl":"10.1016/j.ypmed.2024.108165","url":null,"abstract":"<div><h3>Objectives</h3><div>We present incidence trends of cancer and precancer at human papillomavirus(HPV)-associated sites, and genital warts, including the current burden of HPV-associated disease in Denmark, a country with multi-cohort HPV vaccination.</div></div><div><h3>Method</h3><div>Cases were identified from high-quality nationwide registries (2000−2022). The age-specific incidence rate, age-standardized incidence rate (ASR) and estimated annual percentage change (EAPC) were calculated according to sex and calendar year. The current burden (2020−2022) of HPV-associated disease was estimated as the average annual number of each lesion multiplied by the disease-specific HPV-attributable fraction.</div></div><div><h3>Results</h3><div>ASRs of cervical precancer and genital warts declined markedly in the post-HPV vaccination period – for genital warts corresponding to an EAPC of −13.7 % (−15.0;−12.4)(women) and −8.8 % (−9.4;−8.2)(men), respectively. ASRs of HPV-associated cancer sites increased continuously in men (EAPC: 2.8 % (2.2;3.5)), and the same was observed for non-cervical HPV-associated cancer sites in women (EAPC: 2.5 % (2.0;3.0)). Cervical cancer, however, decreased in the post-HPV vaccination period (EAPC: −2.7 % (−3.8;−1.5)). Age-specific incidence rates of HPV-associated cancer sites decreased slightly in younger women and were stable in younger men, while incidence rates in older men approached or even surpassed that of older women. Data on the current burden showed that cervical precancer and genital warts are still the major contributors to HPV-associated disease, and oropharyngeal cancer now accounts for more annual cases on a population level than cervical cancer.</div></div><div><h3>Conclusion</h3><div>Danish data show decreased incidence of cervical lesions and genital warts in the post-vaccine era. Despite population impact of HPV vaccination, HPV-associated disease remains a public health issue and increasingly among men.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108165"},"PeriodicalIF":4.3,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of a lifestyle behaviour change program on healthcare costs: Quasi-experimental real-world evidence from an open-access mobile health app in the Netherlands 改变生活方式计划对医疗成本的影响:来自荷兰一款开放式移动医疗应用程序的准实验性真实证据。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-10 DOI: 10.1016/j.ypmed.2024.108174
Elena Agachi , Jochen O. Mierau , Koert van Ittersum , Tammo H.A. Bijmolt

Objective

Recognizing the substantial role of modifiable risk factors such as physical inactivity, unhealthy diets, and substance use in driving global healthcare expenses, this study aims to assess the impact of a lifestyle behaviour change mobile health (mHealth) app on healthcare costs within a real-world setting.

Methods

Employing a difference-in-difference approach, this research compared healthcare costs between users of an mHealth app (treatment group) and a propensity score-matched control group of non-users. The study included data from 15,506 participants in the Netherlands, covering healthcare cost records collected from 2015 to 2019.

Results

The implementation of the mHealth app was linked to a steady reduction in healthcare costs, achieving a 4.9 % decrease (β=0.05,95%CI:0.10to0.00) during the first year following the program's implementation, and a further 5.3 % decrease (β=0.05,95%CI:0.10to0.00) in the second year. This healthcare costs reduction is associated with lower expenses for general practitioner services as well as diminished specialist visits. Additionally, increased app use led to further cost reductions, with frequency of use proving more important than intensity.

Conclusions

This study demonstrates that a behaviour change mHealth app is linked to significant reductions in healthcare costs, with more frequent and intense use leading to greater savings. Given their relatively low cost and ability to reach diverse population groups, such apps not only enhance individual health outcomes but can also serve as effective policy tools for large-scale health promotion, supporting broader societal health improvements.
研究目的本研究旨在评估改变生活方式行为的移动医疗(mHealth)应用对现实世界中医疗费用的影响:本研究采用差分法,比较了移动医疗应用程序用户(治疗组)与倾向得分匹配的非用户对照组的医疗费用。研究纳入了荷兰15506名参与者的数据,涵盖2015年至2019年收集的医疗成本记录:移动医疗应用程序的实施与医疗费用的稳步下降有关,在计划实施后的第一年,医疗费用下降了4.9%(β=-0.05,95%CI:-0.10至0.00),第二年进一步下降了5.3%(β=-0.05,95%CI:-0.10至0.00)。医疗成本的降低与全科医生服务费用的降低以及专科医生就诊次数的减少有关。此外,增加应用程序的使用还能进一步降低成本,使用频率比使用强度更重要:这项研究表明,改变行为的移动医疗应用程序可显著降低医疗成本,使用频率和强度越高,节省的费用就越多。鉴于其相对低廉的成本和覆盖不同人群的能力,此类应用程序不仅能提高个人健康水平,还能作为有效的政策工具,促进大规模的健康推广,支持更广泛的社会健康改善。
{"title":"The impact of a lifestyle behaviour change program on healthcare costs: Quasi-experimental real-world evidence from an open-access mobile health app in the Netherlands","authors":"Elena Agachi ,&nbsp;Jochen O. Mierau ,&nbsp;Koert van Ittersum ,&nbsp;Tammo H.A. Bijmolt","doi":"10.1016/j.ypmed.2024.108174","DOIUrl":"10.1016/j.ypmed.2024.108174","url":null,"abstract":"<div><h3>Objective</h3><div>Recognizing the substantial role of modifiable risk factors such as physical inactivity, unhealthy diets, and substance use in driving global healthcare expenses, this study aims to assess the impact of a lifestyle behaviour change mobile health (mHealth) app on healthcare costs within a real-world setting.</div></div><div><h3>Methods</h3><div>Employing a difference-in-difference approach, this research compared healthcare costs between users of an mHealth app (treatment group) and a propensity score-matched control group of non-users. The study included data from 15,506 participants in the Netherlands, covering healthcare cost records collected from 2015 to 2019.</div></div><div><h3>Results</h3><div>The implementation of the mHealth app was linked to a steady reduction in healthcare costs, achieving a 4.9 % decrease (<span><math><mi>β</mi><mo>=</mo><mo>−</mo><mn>0.05</mn><mo>,</mo><mn>95</mn><mo>%</mo><mi>CI</mi><mo>:</mo><mo>−</mo><mn>0.10</mn><mspace></mspace><mtext>to</mtext><mspace></mspace><mn>0.00</mn></math></span>) during the first year following the program's implementation, and a further 5.3 % decrease (<span><math><mi>β</mi><mo>=</mo><mo>−</mo><mn>0.05</mn><mo>,</mo><mn>95</mn><mo>%</mo><mi>CI</mi><mo>:</mo><mo>−</mo><mn>0.10</mn><mspace></mspace><mtext>to</mtext><mo>−</mo><mn>0.00</mn></math></span>) in the second year. This healthcare costs reduction is associated with lower expenses for general practitioner services as well as diminished specialist visits. Additionally, increased app use led to further cost reductions, with frequency of use proving more important than intensity.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that a behaviour change mHealth app is linked to significant reductions in healthcare costs, with more frequent and intense use leading to greater savings. Given their relatively low cost and ability to reach diverse population groups, such apps not only enhance individual health outcomes but can also serve as effective policy tools for large-scale health promotion, supporting broader societal health improvements.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108174"},"PeriodicalIF":4.3,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities in trends of smoke-free home associated with socioeconomic disadvantages in the United States from 2001 to 2019 2001 年至 2019 年美国与社会经济劣势相关的无烟家庭趋势差异。
IF 4.3 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-09 DOI: 10.1016/j.ypmed.2024.108173
Boram Lee , Douglas E. Levy

Objective

To examine disparities in trends of smoke-free home (SFH) rule prevalence in the United States from 2001 to 2019 by individuals' number of socioeconomic disadvantages.

Methods

Data were drawn from the 2001–2019 Tobacco Use Supplements to the U.S. Current Population Survey, a nationally representative cross-sectional survey. The sample comprised respondents (aged≥18 years) who answered items about SFH rules and socioeconomic disadvantage, defined as past-month unemployment, income below the federal poverty line, and/or education less than a high school diploma (N = 867,552). Multivariable logistic regressions estimated associations between adoption of an SFH rule and the number of socioeconomic disadvantages, including interaction terms between time and disadvantages, to assess changes in disparities over time.

Results

SFH prevalence increased substantially from 64.6 % in 2001–2002 to 89.0 % in 2018–2019. Differences in SFH prevalence by socioeconomic disadvantage narrowed somewhat over the 19 years among non-smokers but widened among smokers. Among non-smokers, SFH prevalence increased by 17.2 ppt (76.5 % to 93.7 %) for those without disadvantages, while it increased by 24.3 ppt (61.8 % to 86.1 %) among those with three disadvantages. In contrast, among smokers, increases in SFH prevalence over time were smaller among those with one (22.8 % to 51.5 %), two (19.5 % to 45.1 %), and three disadvantages (17.3 % to 37.1 %), compared with those without disadvantages (27.7 % to 61.4 %). The widened disparities were found even among smokers living with children.

Conclusion

Despite a large increase in the SFH prevalence, disparities remain. Our findings underscore the need for continued efforts to promote SFH, particularly among socioeconomically disadvantaged smokers.
目的研究2001年至2019年美国无烟家庭(SFH)规则普及率趋势的差异,按个人的社会经济劣势数量进行分类:数据来自 2001-2019 年美国当前人口调查烟草使用补充资料,这是一项具有全国代表性的横断面调查。样本包括回答有关 SFH 规则和社会经济劣势(定义为上月失业、收入低于联邦贫困线和/或教育程度低于高中文凭)项目的受访者(年龄≥18 岁)(N = 867,552 人)。多变量逻辑回归估算了采用自费住房规则与社会经济劣势数量之间的关联,包括时间与劣势之间的交互项,以评估差异随时间的变化:SFH的流行率从2001-2002年的64.6%大幅上升至2018-2019年的89.0%。19年间,非吸烟者中因社会经济劣势而导致的SFH患病率差异有所缩小,但吸烟者中的差异却有所扩大。在非吸烟者中,无劣势人群的SFH患病率增加了17.2个百分点(从76.5%上升到93.7%),而有三种劣势人群的SFH患病率增加了24.3个百分点(从61.8%上升到86.1%)。相比之下,在吸烟者中,有一项不利条件(22.8%至51.5%)、两项不利条件(19.5%至45.1%)和三项不利条件(17.3%至37.1%)的吸烟者的 SFH 患病率随时间推移的增长幅度要小于没有不利条件的吸烟者(27.7%至61.4%)。即使在与子女同住的吸烟者中,差距也有所扩大:尽管 SFH 患病率大幅上升,但差距依然存在。我们的研究结果表明,有必要继续努力推广自律吸烟,尤其是在社会经济条件较差的吸烟者中。
{"title":"Disparities in trends of smoke-free home associated with socioeconomic disadvantages in the United States from 2001 to 2019","authors":"Boram Lee ,&nbsp;Douglas E. Levy","doi":"10.1016/j.ypmed.2024.108173","DOIUrl":"10.1016/j.ypmed.2024.108173","url":null,"abstract":"<div><h3>Objective</h3><div>To examine disparities in trends of smoke-free home (SFH) rule prevalence in the United States from 2001 to 2019 by individuals' number of socioeconomic disadvantages.</div></div><div><h3>Methods</h3><div>Data were drawn from the 2001–2019 Tobacco Use Supplements to the U.S. Current Population Survey, a nationally representative cross-sectional survey. The sample comprised respondents (aged≥18 years) who answered items about SFH rules and socioeconomic disadvantage, defined as past-month unemployment, income below the federal poverty line, and/or education less than a high school diploma (<em>N</em> = 867,552). Multivariable logistic regressions estimated associations between adoption of an SFH rule and the number of socioeconomic disadvantages, including interaction terms between time and disadvantages, to assess changes in disparities over time.</div></div><div><h3>Results</h3><div>SFH prevalence increased substantially from 64.6 % in 2001–2002 to 89.0 % in 2018–2019. Differences in SFH prevalence by socioeconomic disadvantage narrowed somewhat over the 19 years among non-smokers but widened among smokers. Among non-smokers, SFH prevalence increased by 17.2 ppt (76.5 % to 93.7 %) for those without disadvantages, while it increased by 24.3 ppt (61.8 % to 86.1 %) among those with three disadvantages. In contrast, among smokers, increases in SFH prevalence over time were smaller among those with one (22.8 % to 51.5 %), two (19.5 % to 45.1 %), and three disadvantages (17.3 % to 37.1 %), compared with those without disadvantages (27.7 % to 61.4 %). The widened disparities were found even among smokers living with children.</div></div><div><h3>Conclusion</h3><div>Despite a large increase in the SFH prevalence, disparities remain. Our findings underscore the need for continued efforts to promote SFH, particularly among socioeconomically disadvantaged smokers.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"189 ","pages":"Article 108173"},"PeriodicalIF":4.3,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Preventive medicine
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