Preventive medicine最新文献_第2页

Mapping school food provision models in European cities: Operational, infrastructural, and financial insights 绘制欧洲城市的学校食品供应模式：运营、基础设施和财务见解。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-01-19 DOI: 10.1016/j.ypmed.2026.108515

Evelin Piirsalu , Brigita Tool , Irene Vidal , Manuel Franco

Objective

This study aims to provide a comparative overview of school food provision models in 17 cities across 12 European countries. It explores the operational, infrastructural, and financial dimensions of these models, identifying key trade-offs, challenges and opportunities for promoting healthy and sustainable school food environments.

Methods

Data were collected via an electronic questionnaire administered to SchoolFood4Change project partners in 2022. The questionnaire covered meal types and costs, operational and manufacturing models, and kitchen infrastructure. Supplementary desk research was conducted to clarify responses and gain a deeper understanding of the findings' context.

Results

The analysis reveals that school food provision models are more influenced by institutional, historical, and policy contexts than by city size. Contract catering dominates, yet in-house systems persist where welfare traditions and nutrition education policies emphasise child health and learning. Centralised kitchens often reflect historical planning or socialist legacies, while mixed systems arise in decentralised governance contexts.

Conclusions

Organisational diversity stems from the interaction of governance structures, policy priorities, and infrastructure, illustrating how Europe's school food systems balance economic efficiency with social and educational goals for children's wellbeing. This study contributes to a deeper understanding of school food provision models in Europe.

目的：本研究旨在对欧洲12个国家17个城市的学校供餐模式进行比较综述。它探讨了这些模式的运营、基础设施和财务层面，确定了促进健康和可持续学校食品环境的关键权衡、挑战和机遇。方法：通过电子问卷收集数据，并于2022年向SchoolFood4Change项目合作伙伴发放调查问卷。调查问卷涵盖了膳食类型和成本、运营和制造模式以及厨房基础设施。补充课桌研究是为了澄清回应，并更深入地了解调查结果的背景。结果：分析表明，学校供餐模式更受制度、历史和政策背景的影响，而不是城市规模的影响。合同餐饮占主导地位，但在福利传统和营养教育政策强调儿童健康和学习的地方，内部体系仍然存在。集中式厨房通常反映了历史规划或社会主义遗产，而混合系统则出现在分散的治理环境中。结论：组织多样性源于治理结构、政策优先事项和基础设施的相互作用，说明了欧洲学校食品系统如何平衡经济效率与儿童福利的社会和教育目标。本研究有助于加深对欧洲学校供餐模式的理解。

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引用次数: 0

Beyond glyphosate: Is it feasible to counterbalance perverse incentives to profit from preventable disease? 超越草甘膦：是否有可能抵消从可预防疾病中获利的不正当动机？

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-01-19 DOI: 10.1016/j.ypmed.2026.108513

Carolina Donat-Vargas , Laura N. Vandenberg , Juan Aguacil , Duk-Hee Lee , Miguel Angel Martínez-González , Kurt Straif , Miquel Porta

引用次数: 0

Combined effects of smoking and hormonal contraceptives in the occurrence of inflammatory bowel disease – A weighted Cox analysis in a nested case-control study in Quebec, Canada 吸烟和激素避孕药对炎症性肠病发生的综合影响——加拿大魁北克一项巢式病例对照研究的加权Cox分析。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-01-14 DOI: 10.1016/j.ypmed.2026.108511

Canisius Fantodji , Marie-Claude Rousseau , Belinda Nicolau , Sreenath Madathil , Andrea Benedetti , Prévost Jantchou

Objective

Hormonal contraceptives increase nicotine absorption. Their joint effect with smoking on inflammatory bowel disease remains unclear. We assessed independent and joint associations of smoking and hormonal contraception with Crohn's disease and ulcerative colitis.

Methods

In 2021, we conducted a nested case-control study with cumulative sampling of controls, in Quebec, Canada. Cases were identified with health services-based validated algorithms. Smoking, hormonal contraception, and covariates were self-reported. Time-dependent exposures were analyzed in 2024 using weighted Cox models to estimate hazard ratios (HR) and 95% confidence intervals (95% CI) and assess additive and multiplicative interactions.

Results

The study included 1718 women (591 controls, 790 Crohn's disease, 337 ulcerative colitis cases). Compared with non-smokers non-users of hormonal contraception, former smokers using hormonal contraceptives had increased Crohn's disease (HR = 2.45; 95% CI: 1.51, 3.96) and ulcerative colitis risks (HR = 2.88; 95% CI: 1.65, 5.02). Current smokers using hormonal contraceptives had elevated risks of Crohn's disease (HR = 2.62; 95% CI: 1.93, 3.56) but not ulcerative colitis (HR = 0.72; 95% CI: 0.42, 1.17). A negative additive interaction was observed for ulcerative colitis with no multiplicative interactions.

Conclusions

Smoking and hormonal contraception are independently associated with Crohn's disease, but not ulcerative colitis, with implications for inflammatory bowel disease risk assessment in women.

目的：激素避孕药增加尼古丁吸收。它们与吸烟对炎症性肠病的共同作用尚不清楚。我们评估了吸烟和激素避孕与克罗恩病和溃疡性结肠炎的独立和联合关联。方法：2021年，我们在加拿大魁北克省进行了一项巢式病例对照研究。使用基于卫生服务的经过验证的算法识别病例。吸烟、激素避孕和协变量均为自我报告。使用加权Cox模型分析2024年的时间依赖性暴露，以估计风险比（HR）和95%置信区间（95% CI），并评估加性和乘法相互作用。结果：该研究包括1718名妇女（591名对照组，790名克罗恩病患者，337名溃疡性结肠炎患者）。与未使用激素避孕药的非吸烟者相比，使用激素避孕药的前吸烟者克罗恩病（HR = 2.45;95% CI: 1.51, 3.96）和溃疡性结肠炎的风险增加（HR = 2.88;95% CI: 1.65,5.02）。目前使用激素避孕药的吸烟者患克罗恩病的风险增加（HR = 2.62;95% CI: 1.93, 3.56），但溃疡性结肠炎的风险没有增加（HR = 0.72;95% CI: 0.42, 1.17）。在溃疡性结肠炎中观察到负的加性相互作用，而没有乘法相互作用。结论：吸烟和激素避孕与克罗恩病独立相关，但与溃疡性结肠炎无关，这对女性炎症性肠病风险评估具有重要意义。

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引用次数: 0

Major changes in cervical cancer screening in the US 美国宫颈癌筛查的主要变化。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-01-14 DOI: 10.1016/j.ypmed.2026.108512

Keely K. Ulmer , Lisa F. Soltani , Ilana Addis , Alisa P. Young , Diane M Harper

引用次数: 0

Breastfeeding patterns during the 2022 United States infant formula shortage and projected infant healthcare costs 2022年美国婴儿配方奶粉短缺期间的母乳喂养模式和预计的婴儿医疗保健费用。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-01-13 DOI: 10.1016/j.ypmed.2026.108503

Luis Seoane Estruel , Tatiana Andreyeva

Objective

Suboptimal breastfeeding in the U.S. carries substantial health and economic costs and is marked by persistent disparities. The 2022 formula shortage coincided with disruptions in infant feeding practices. This study documents changes in breastfeeding during the shortage period and projects associated infant illness and healthcare costs.

Methods

Using 2017–2022 Pregnancy Risk Assessment Monitoring System data, we applied Bayesian structural time-series models to estimate deviations in breastfeeding initiation and duration during the shortage period relative to prior trends. We then used Monte Carlo simulation to project infant illness and healthcare costs.

Results

During the 2022 formula shortage, breastfeeding for at least four months was higher by 3.43 percentage points (95% credible interval [CrI]: 1.11, 5.74). Breastfeeding at one, two, and three months postpartum was 2.49 to 3.55 percentage points higher, and initiation was higher by 1.54 percentage points (95% CrI: 0.46, 2.59). Estimates varied across sociodemographic groups and were larger among less advantaged mothers, corresponding with smaller observed breastfeeding disparities. The simulation projects annual healthcare costs approximately $420 million lower.

Conclusions

During the formula shortage groups with historically lower breastfeeding rates exhibited higher breastfeeding levels, highlighting the relevance of breastfeeding trends for discussions of infant disease and healthcare costs.

目的：在美国，次优母乳喂养带来了巨大的健康和经济成本，并以持续的差距为标志。2022年的配方奶粉短缺与婴儿喂养方式的中断同时发生。这项研究记录了短缺时期母乳喂养的变化，并对与婴儿疾病和保健费用相关的项目进行了研究。方法：利用2017-2022年妊娠风险评估监测系统数据，应用贝叶斯结构时间序列模型估计母乳喂养不足期母乳喂养开始和持续时间相对于前期趋势的偏差。然后，我们使用蒙特卡罗模拟来预测婴儿疾病和医疗保健成本。结果：在2022年配方奶粉短缺期间，至少4个月母乳喂养高3.43个百分点（95%可信区间[CrI]: 1.11, 5.74）。产后1个月、2个月和3个月母乳喂养的年龄点高出2.49 ~ 3.55%，开始母乳喂养的年龄点高出1.54个百分点（95% CrI: 0.46, 2.59）。估算值在不同的社会人口群体中有所不同，在条件较差的母亲中更大，与观察到的母乳喂养差异较小相对应。该模拟项目每年的医疗保健费用降低了约4.2亿美元。结论：在配方奶粉短缺的群体中，母乳喂养率历史上较低的群体表现出更高的母乳喂养水平，突出了母乳喂养趋势与婴儿疾病和医疗保健费用讨论的相关性。

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引用次数: 0

Risk factors for running-related injuries among Chinese Marathon runners: A cross-sectional study 中国马拉松运动员跑步损伤的危险因素：一项横断面研究。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-01-11 DOI: 10.1016/j.ypmed.2026.108510

Xiangxin Li , Yan Chen , Xueyuan Zhao , Wei Wen , Jingyi Zhang , Junqiang Qiu

Purpose

This study aimed to investigate the incidence and risk factors of running-related injuries (RRIs) among Chinese marathon runners.

Methods

A nationwide cross-sectional survey was conducted in China from January to December 2024, with 5668 marathon runners participating in full or half marathons. Data on demographics, training characteristics, and RRIs in the past six months were collected through validated questionnaires. Logistic regression was used to identify predictors of RRIs.

Results

The overall incidence of RRIs was 46.5%, with a higher prevalence in males compared to females (p < 0.01). The most frequently affected areas were the knee (29.6%), the toe (22.9%), and the ankle (19.4%).Multivariable analysis showed that increasing age (OR = 0.98), longer running experience (≥7 years: OR = 0.71), and lower training levels (Public L1: OR = 0.74, Public L2: OR = 0.66, Unclassified: OR = 0.53) were protective factors. Higher body mass index (BMI) (24 ≤ BMI < 28: OR = 1.49; ≥28: OR = 1.67) and elite-level training were associated with increased injury risk.

Conclusion

This study highlights a high burden of RRIs among Chinese marathon runners, with key modifiable risk factors including BMI and training intensity, while age and running experience offer protective effects.

目的：调查我国马拉松运动员跑步相关损伤的发生率及危险因素。方法：于2024年1 - 12月在全国范围内对5668名参加全程或半程马拉松的马拉松运动员进行横断面调查。通过有效的问卷调查收集了过去六个月的人口统计、培训特征和RRIs数据。采用Logistic回归来确定风险风险的预测因素。结果：RRIs的总发病率为46.5%，男性高于女性（p ）结论：本研究表明，中国马拉松运动员的RRIs负担较高，主要可改变的危险因素包括BMI和训练强度，而年龄和跑步经验具有保护作用。

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引用次数: 0

Public responses to risk communication during the 2025 Chikungunya outbreak in China: Implications for future epidemic preparedness 2025年中国基孔肯雅热暴发期间公众对风险沟通的反应：对未来流行病防范的影响

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-01-10 DOI: 10.1016/j.ypmed.2026.108507

Xiaomin Wang , Ran Zhang , Yirui Wang , Xudong Zhou

Objective

To examine associations between exposure to risk communication, risk perception, and critical health literacy, and their associations with public preparedness and preventive behaviors during the Chikungunya epidemic in China.

Methods

We conducted a cross-sectional survey in August 2025 among 1102 residents across three Chinese provinces, stratified by epidemiological risk. Among participants aware of the outbreak (n = 761), multivariable logistic regression models assessed associations between risk communication, risk perception, critical health literacy, and preventive behaviors, adjusting for sociodemographic characteristics.

Results

Among participants, 69.06% reported awareness of Chikungunya. Higher exposure to risk communication was associated with increased adoption of all preparedness and preventive behaviors (aORs 1.31–1.50). Perceived environmental risk was associated with using mosquito nets [aOR = 1.37, 95% CI (1.14, 1.64)], screening windows [aOR = 1.45, 95%CI (1.18, 1.78)], and purchasing medications, including paracetamol, antibiotics, and antivirals (aORs up to 1.73). Higher critical health literacy was associated with reduced likelihood of purchasing inappropriate medications, specifically antibiotics [aOR = 0.72, 95% CI (0.56, 0.92)] and antivirals [aOR = 0.58, 95% CI (0.45, 0.75)].

Conclusions

Governmental risk communication and critical health literacy were strongly associated with public preventive behaviors. Findings suggest interventions to improve critical health literacy and risk communication could enhance preparedness and safer practices in future epidemics.

目的：探讨中国基孔肯雅热流行期间暴露风险沟通、风险认知和关键健康素养之间的关系，以及它们与公众准备和预防行为的关系。方法：我们于2025年8月对中国三个省份的1102名居民进行了横断面调查，按流行病学风险分层。在了解疫情的参与者中（n = 761），多变量logistic回归模型评估了风险沟通、风险感知、关键健康素养和预防行为之间的关联，并根据社会人口统计学特征进行了调整。结果：69.06%的参与者报告了基孔肯雅热的知晓率。风险沟通的增加与所有准备和预防行为的采用增加相关（aORs 1.31-1.50）。感知到的环境风险与使用蚊帐[aOR = 1.37,95%CI(1.14, 1.64)]、纱窗[aOR = 1.45,95%CI(1.18, 1.78)]和购买药物（aOR高达1.73）相关。较高的关键健康素养与购买不适当药物的可能性降低相关，特别是抗生素[aOR = 0.72,95% CI(0.56, 0.92)]和抗病毒药物[aOR = 0.58,95% CI(0.45, 0.75)]。结论：政府风险沟通和关键健康素养与公众预防行为密切相关。研究结果表明，改善关键卫生知识和风险沟通的干预措施可以加强对未来流行病的防范和更安全的做法。

{"title":"Public responses to risk communication during the 2025 Chikungunya outbreak in China: Implications for future epidemic preparedness","authors":"Xiaomin Wang , Ran Zhang , Yirui Wang , Xudong Zhou","doi":"10.1016/j.ypmed.2026.108507","DOIUrl":"10.1016/j.ypmed.2026.108507","url":null,"abstract":"<div><h3>Objective</h3><div>To examine associations between exposure to risk communication, risk perception, and critical health literacy, and their associations with public preparedness and preventive behaviors during the Chikungunya epidemic in China.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional survey in August 2025 among 1102 residents across three Chinese provinces, stratified by epidemiological risk. Among participants aware of the outbreak (<em>n</em> = 761), multivariable logistic regression models assessed associations between risk communication, risk perception, critical health literacy, and preventive behaviors, adjusting for sociodemographic characteristics.</div></div><div><h3>Results</h3><div>Among participants, 69.06% reported awareness of Chikungunya. Higher exposure to risk communication was associated with increased adoption of all preparedness and preventive behaviors (aORs 1.31–1.50). Perceived environmental risk was associated with using mosquito nets [aOR = 1.37, 95% CI (1.14, 1.64)], screening windows [aOR = 1.45, 95%CI (1.18, 1.78)], and purchasing medications, including paracetamol, antibiotics, and antivirals (aORs up to 1.73). Higher critical health literacy was associated with reduced likelihood of purchasing inappropriate medications, specifically antibiotics [aOR = 0.72, 95% CI (0.56, 0.92)] and antivirals [aOR = 0.58, 95% CI (0.45, 0.75)].</div></div><div><h3>Conclusions</h3><div>Governmental risk communication and critical health literacy were strongly associated with public preventive behaviors. Findings suggest interventions to improve critical health literacy and risk communication could enhance preparedness and safer practices in future epidemics.</div></div>","PeriodicalId":20339,"journal":{"name":"Preventive medicine","volume":"204 ","pages":"Article 108507"},"PeriodicalIF":3.2,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An equity audit on intervention effects of a cardiometabolic risk reduction program for women with a history of gestational diabetes in Victoria, Australia 对澳大利亚维多利亚州有妊娠糖尿病史的妇女心脏代谢风险降低项目干预效果的公平审计。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-01-10 DOI: 10.1016/j.ypmed.2026.108509

Gebresilasea Gendisha Ukke , Jacqueline A. Boyle , Rajshree Thapa , Jenna Van Der-Velden , Carli Leishman , Christopher Gilfillan , Ahmed Reja , Siew Lim

Objective

To investigate the effectiveness of the Life! program—a prevention initiative for type 2 diabetes, heart disease, and stroke—on behavioural and anthropometric outcomes in women with a history of gestational diabetes mellitus, across diverse sociodemographic backgrounds.

Methods

This study analysed the data collected from women who participated in the Life! program in Victoria, Australia from 2014 to 2022. Logistic regression analysis was undertaken to assess the associations of socioeconomic status, place of residence, employment status and country of birth with behavioural and anthropometric outcomes six months after enrolment.

Results

There were significant improvements in anthropometric and behavioural outcomes. Women with low income were least likely to improve fat (AOR = 0.64, 95% CI: 0.50, 0.83) and fibre (AOR = 0.70, 95% CI: 0.54, 0.91) intakes compared to women with middle income. Being 40 to 59 years old was associated with a greater improvement in fat intake compared with being under 30 years (AOR = 1.72, 95% CI: 1.06, 2.80).

Conclusion

While the Life program is effective in reducing risks in women with a history of gestational diabetes, less dietary improvements were seen in those with lower incomes or younger, which needs to be addressed to reduce disparities in type 2 diabetes prevalence.

目的：探讨Life！项目-预防2型糖尿病、心脏病和中风的倡议-在不同社会人口背景下有妊娠糖尿病史的妇女的行为和人体测量结果方法：本研究分析了参与Life！2014年至2022年在澳大利亚维多利亚州学习。采用Logistic回归分析来评估社会经济地位、居住地、就业状况和出生国家与入组6个月后行为和人体测量结果的关系。结果：在人体测量和行为方面有显著改善。与中等收入女性相比，低收入女性最不可能改善脂肪（AOR = 0.64,95% CI: 0.50, 0.83）和纤维（AOR = 0.70,95% CI: 0.54, 0.91）摄入。40 - 59岁 与30岁以下 相比，脂肪摄入量的改善更大（AOR = 1.72,95% CI: 1.06, 2.80）。结论：Life项目在降低有妊娠糖尿病史的妇女的风险方面是有效的，但在收入较低或较年轻的妇女中，饮食改善较少，这需要解决，以减少2型糖尿病患病率的差异。

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引用次数: 0

Increasing use of cannabis edibles in response to recreational cannabis legalization in the United States 随着美国娱乐性大麻合法化，大麻食品的使用越来越多。

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-01-09 DOI: 10.1016/j.ypmed.2026.108508

Summer Sherburne Hawkins , Christopher E. Baidoo , Rebekah Levine Coley , Ryan S. Centanni , Christopher F. Baum

Objective

To evaluate the associations between recreational cannabis legalization in the United States and primary mode of cannabis use (smoking, eating/drinking, vaporizing/dabbing) overall and across groups.

Methods

We linked data on 69,109 adults reporting past month cannabis use from 37 states in the 2017–2023 Behavioral Risk Factor Surveillance System with recreational cannabis legalization and retail sales. Using multinomial logit regression models, we examined the associations between legalization and primary mode of cannabis use overall and by demographic and higher-risk strata, with demographic and policy controls and state and year fixed effects.

Results

Among cannabis users, smoking declined but remained the most prevalent mode of cannabis use in 2023 (62.7%), followed by eating/drinking (21.5%), and vaporizing/dabbing (15.8%). Compared to smoking and vaping/dabbing cannabis, the likelihood of eating/drinking cannabis increased by 35% (adjusted relative risk ratio 1.35; 95% CI 1.20, 1.52) and 33% (1.33; 1.14, 1.55), respectively, post-legalization. Similar patterns emerged in response to retail sales. There was evidence of larger increases in eating/drinking cannabis among males than females post-legalization, and among middle-aged and older adults than younger adults after retail store openings.

Conclusion

Recreational cannabis legalization and retail sales led to more frequent use of cannabis in edible and drinkable forms.

目的：评估美国娱乐性大麻合法化与大麻主要使用方式（吸烟、吃/喝、汽化/轻吸）之间的关系。方法：我们将2017-2023年行为风险因素监测系统中来自37个州的69109名成年人报告的上个月大麻使用数据与休闲大麻合法化和零售销售联系起来。使用多项逻辑回归模型，我们研究了总体上、人口统计学和高风险阶层的大麻合法化与主要使用方式之间的关系，以及人口统计学和政策控制以及州和年份固定的影响。结果：在大麻使用者中，吸烟有所下降，但在2023年仍是最普遍的大麻使用方式（62.7%），其次是吃/喝（21.5%）和蒸发/轻吸（15.8%）。与吸烟和吸/吸大麻相比，大麻合法化后，吃/喝大麻的可能性分别增加了35%（调整后的相对风险比1.35;95% CI 1.20, 1.52）和33%（1.33;1.14,1.55）。零售业也出现了类似的模式。有证据表明，大麻合法化后，男性吃/喝大麻的人数比女性多，零售商店开业后，中年和老年人吃/喝大麻的人数比年轻人多。结论：娱乐性大麻合法化和零售销售导致食用和饮用形式的大麻使用更加频繁。

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引用次数: 0

The dual risk profile of site-specific cancers in vitiligo: A systematic review and meta-analysis 白癜风部位特异性癌症的双重风险概况：系统回顾和荟萃分析

IF 3.2 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2026-01-07 DOI: 10.1016/j.ypmed.2026.108504

Yanbin Chen , Yongyi Xie , Nanhui Wu , Ruoqi Wang , Suwei Tang , Mingyuan Xu , Xin Ma , Yeqiang Liu

Objectives

Site-specific cancer risks in vitiligo patients remain inconsistent, with paradoxical evidence for individual malignancies and no synthesis.

Methods

Systematic searches in PubMed (1996–February 2025), Embase (1947–February 2025), Web of Science (1997–February 2025), Cochrane Library (1996–February 2025) (pre-inception retroactively indexed studies, January 1900–February 2025); 13 included in our meta-analysis. Stata 18.0 computed pooled RRs (95% CIs); heterogeneity assessed via publication bias, subgroup and sensitivity analyses.

Results

The study incorporated thirteen studies. It is evident that there is a statistically significant correlation between the occurrence of vitiligo and an elevated risk of developing thyroid cancer (RR = 1.59, 95% CI [1.19, 2.12]). Conversely, a significant reduction in risk was observed for overall cancer (RR = 0.77, 95% CI [0.66, 0.90]), cancers of the respiratory system (RR = 0.75, 95% CI [0.66, 0.84]), digestive system (RR = 0.74, 95% CI [0.63, 0.87]), and skin cancers (RR = 0.58, 95% CI [0.36, 0.93]).

Conclusions

This study demonstrates a dual cancer risk profile in vitiligo: increased risk for thyroid cancer, but decreased risk for overall cancer, internal malignancies (respiratory and digestive systems) and skin cancers. These findings suggest the potential need for customized cancer surveillance strategies and investigation into preventive interventions.

白癜风患者的特异性癌症风险仍然不一致，个别恶性肿瘤的证据相互矛盾，没有综合。方法系统检索PubMed（1996 - 2025年2月）、Embase（1947 - 2025年2月）、Web of Science（1997 - 2025年2月）、Cochrane Library（1996 - 2025年2月）（1900年1月- 2025年2月）（成立前追溯索引研究）；13例纳入meta分析。Stata计算合并危险度为18.0 (95% ci)；通过发表偏倚、亚组和敏感性分析评估异质性。结果本研究纳入13项研究。可见，白癜风的发生与甲状腺癌发病风险升高之间存在显著的统计学相关性（RR = 1.59, 95% CI[1.19, 2.12]）。相反，总体癌症（RR = 0.77, 95% CI[0.66, 0.90]）、呼吸系统癌症（RR = 0.75, 95% CI[0.66, 0.84]）、消化系统癌症（RR = 0.74, 95% CI[0.63, 0.87]）和皮肤癌（RR = 0.58, 95% CI[0.36, 0.93]）的风险显著降低。结论：该研究表明白癜风具有双重癌症风险：甲状腺癌风险增加，但整体癌症、内部恶性肿瘤（呼吸系统和消化系统）和皮肤癌风险降低。这些发现表明，可能需要定制癌症监测策略和调查预防干预措施。

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引用次数: 0