Preventive medicine最新文献_第6页

Reprint of: Smoking and pulmonary health in women: A narrative review and behavioral health perspective 重印本：女性吸烟与肺部健康：叙述性综述和行为健康视角。

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2024-11-01 DOI: 10.1016/j.ypmed.2024.108113

Katherine E. Menson , Sulamunn R.M. Coleman

Objective

Cigarette smoking prevalence has declined slower among women than men, and smoking-related pulmonary disease (PD) has risen among women. Given these trends, there is a critical need to understand and mitigate PD risk among women who smoke. The purpose of this narrative review and commentary is to highlight important evidence from the literature on smoking and PD among women.

Methods

This review focuses broadly on examining cigarette smoking and PD among women within six topic areas: (1) demographic characteristics and prevalence of smoking, (2) smoking behavior, (3) lung cancer, (4) obstructive PD, (5) diagnostic and treatment disparities, and (6) gaps in the literature and potential directions for future research and treatment.

Results

Growing evidence indicates that compared to men, women are at increased risk for developing smoking-related PD and poorer PD outcomes. Gender disparities in smoking-related PD may be largely accounted for by genetic differences and sex hormones contributing to PD pathogenesis and presentation, smoking behavior, nicotine dependence, and pathogen/carcinogen clearance. Moreover, gender disparities in smoking-related PD may be exacerbated by important social determinants (e.g., women with less formal education and those from minoritized groups may be at especially high risk for poor PD outcomes due to higher rates of smoking).

Conclusion

Rising rates of smoking-related PD among women risk widening diagnostic and treatment disparities. Ongoing research is needed to explore potentially complex relationships between sex, gender, and smoking-related PD processes and outcomes, and to improve smoking-cessation and PD treatment for women.

目的：女性吸烟率的下降速度慢于男性，而与吸烟相关的肺部疾病（PD）在女性中有所上升。鉴于这些趋势，我们亟需了解并降低吸烟女性患肺部疾病的风险。这篇叙述性综述和评论旨在强调女性吸烟和肺部疾病文献中的重要证据：方法：本综述主要从以下六个方面对女性吸烟与帕金森病进行研究：（1）人口特征和吸烟率；（2）吸烟行为；（3）肺癌；（4）阻塞性帕金森病；（5）诊断和治疗差异；（6）文献中的空白以及未来研究和治疗的潜在方向：越来越多的证据表明，与男性相比，女性罹患与吸烟相关的帕金森病的风险更高，且帕金森病的治疗效果更差。与吸烟相关的帕金森病的性别差异可能在很大程度上是由遗传差异和性激素造成的，而遗传差异和性激素又与帕金森病的发病机制和表现、吸烟行为、尼古丁依赖以及病原体/致癌物质清除有关。此外，与吸烟相关的帕金森病的性别差异可能会因重要的社会决定因素而加剧（例如，正规教育程度较低的女性和来自少数群体的女性可能因吸烟率较高而特别容易出现帕金森病的不良后果）：结论：女性中与吸烟相关的帕金森病发病率不断上升，有可能扩大诊断和治疗方面的差异。需要持续开展研究，探索性、性别和吸烟相关的帕金森病过程和结果之间潜在的复杂关系，并改善女性的戒烟和帕金森病治疗。

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引用次数: 0

Behavior change, health, and health disparities 2024: Smoking and other tobacco use among women and girls 行为改变、健康和健康差异 2024：妇女和女童吸烟及其他烟草使用情况。

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2024-11-01 DOI: 10.1016/j.ypmed.2024.108155

Stephen T. Higgins

This Special Issue (SI) of Preventive Medicine is the 11th in an annual series on behavior change, health, and health disparities. The theme of this 2024 issue is Smoking and Other Tobacco Use among Women and Girls. Cigarette smoking remains the single most preventable cause of death in the U.S., causing the premature death of more than 200,000 U.S. women annually, a mortality rate that far exceeds levels from conditions more commonly associated with premature death in women (e.g., breast cancer). Of course, cigarette smoking among women and girls is also a well-known cause of intergenerational adverse health effects. Women and girls are also using e-cigarettes and many other tobacco products that are flooding the U.S. tobacco marketplace. This SI includes eleven peer-reviewed articles that advance knowledge across a wide range of topics on disproportionate adverse effects, prevalence, and risk factors for cigarette smoking and other tobacco use in women and girls.

本期《预防医学》特刊（SI）是关于行为改变、健康和健康差异的年度系列的第 11 期。本期特刊的主题是 "妇女和女孩吸烟及其他烟草使用"。在美国，吸烟仍然是唯一最可预防的死因，每年导致 20 多万美国妇女过早死亡，其死亡率远远超过更常见的与妇女过早死亡有关的疾病（如乳腺癌）。当然，妇女和女童吸烟也是造成代际不良健康影响的一个众所周知的原因。妇女和女孩还在使用电子烟和其他许多充斥美国烟草市场的烟草产品。本 SI 共收录了 11 篇经同行评审的文章，这些文章就妇女和女童吸烟及其他烟草使用的不成比例的不良影响、流行率和风险因素等广泛主题增进了知识。

引用次数: 0

Emotional barriers pose the greatest threat to cervical cancer screening for young adult women in the United Kingdom 在英国，情感障碍是对年轻成年女性进行宫颈癌筛查的最大威胁。

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2024-10-30 DOI: 10.1016/j.ypmed.2024.108160

Karagh J. Brennan, Jonathon L. Reay

Objective

Low cervical screening coverage rate is the root-cause of cervical cancer mortality in the United Kingdom (UK), with 99 % of deaths being considered preventable. Research has consistently categorised reasons for non-attendance into emotional, practical, and cognitive barriers. Despite this, public health interventions have been unable to improve coverage rates. We propose a lifespan perspective is needed, to enable targeted interventions at appropriate milestones (i.e., common life events) during a woman's life. We start this lifespan perspective by investigating the perceived barriers young women report, who have and have not yet been invited to their first cervical screen (i.e., a common life event).

Methods

Twenty-nine women not yet invited to their first cervical screen and twenty women who confirmed they received their invite and confirmed attendance status, rated the likelihood of emotional, practical, and cognitive barriers affecting their attendance at their next cervical screen. Data collected between January and April 2018.

Results

Women who did not attend their first screen, rated emotional barriers significantly higher than all groups, and cognitive barriers higher than those women who did attend. Results highlight, for the first time, that commonly reported barriers are present up to seven years prior to a woman's first eligible cervical screen, with emotional barriers rated most strongly.

Conclusion

Emotional barriers pose the greatest threat to cervical screening attendance in young adult women. Interventions should start at school to encourage cervical screening to be viewed as routine healthcare. Future research should continue a lifespan perspective, indexed to common life events.

目的：宫颈癌筛查覆盖率低是导致英国宫颈癌死亡的根本原因，其中 99% 的死亡被认为是可以预防的。研究一直将不参加筛查的原因分为情感障碍、实际障碍和认知障碍。尽管如此，公共卫生干预措施仍无法提高覆盖率。我们提出需要从生命周期的角度出发，在妇女一生中适当的里程碑（即常见的生命事件）上采取有针对性的干预措施。我们从生命周期的角度出发，调查了已经和尚未被邀请进行首次宫颈筛查（即常见的生命事件）的年轻女性所反映的感知障碍：29名尚未受邀参加首次宫颈筛查的女性和20名确认收到邀请并确认出席情况的女性，对影响她们参加下一次宫颈筛查的情感、实际和认知障碍的可能性进行评分。数据收集时间为 2018 年 1 月至 4 月：未参加首次筛查的妇女对情感障碍的评分明显高于所有组别，对认知障碍的评分高于参加筛查的妇女。结果首次强调，在妇女首次接受合格宫颈筛查之前的七年内，普遍报告的障碍都存在，其中情感障碍的评价最高：结论：情感障碍对年轻成年女性参加宫颈筛查构成了最大的威胁。干预措施应从学校开始，鼓励将宫颈筛查视为常规保健。未来的研究应继续从生命周期的角度出发，以常见的生活事件为索引。

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引用次数: 0

Impact of perceived neighborhood social cohesion on vaccination intentions in the post-pandemic era 后流行病时代邻里社会凝聚力对疫苗接种意愿的影响。

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2024-10-29 DOI: 10.1016/j.ypmed.2024.108158

Anna L. Chupak , Caroline Rudisill , Sayward Harrison , Katie Linvill , Joan Costa-Font , Peiyin Hung , Xiaoming Li

Objective

To examine the relationship between perceived neighborhood social cohesion (NSC) and intentions to obtain seasonal influenza and COVID-19 vaccines among US adults post COVID-19 pandemic.

Methods

We conducted a cross-sectional, nationally representative survey of US residents (N = 2189) in May 2023 on their perceived NSC, COVID-19 and seasonal influenza vaccination intentions, healthcare access, perceived risk of COVID-19 or flu infection, loneliness, and trust in doctors. We used bivariate probit regressions to examine joint associations between perceived NSC and intentions to receive influenza and COVID-19 vaccines, controlling for several participant characteristics (e.g., race).

Results

2164 respondents provided consent to study questions. Trust-related NSC (trust in neighbors) was positively associated with intentions to become vaccinated against both influenza and COVID-19 viruses. Higher relational NSC (perception of a close-knit neighborhood) was positively associated while higher value-based NSC (perception that neighbors share the same values) was negatively associated with intentions to become vaccinated against COVID-19. Healthcare access, perceived risk of infection (COVID-19 or flu), and trust in doctors were positively associated with intentions to become vaccinated against both viruses.

Conclusions

In a post-pandemic era, higher trust-related and relational, perceived NSC (vaccine-dependent), greater access to healthcare, higher perceived risk of infection, and greater trust in doctors were related to higher influenza and COVID-19 vaccination intentions, while higher value-based NSC was related to lower COVID-19 vaccination intentions among US adults. Thus, specific aspects of NSC, healthcare access barriers, misinformation on infection risk, and medical mistrust may influence an individual's willingness and ultimate decision to become vaccinated.

目的研究COVID-19大流行后美国成年人感知的邻里社会凝聚力（NSC）与接种季节性流感疫苗和COVID-19疫苗意愿之间的关系：我们于 2023 年 5 月对美国居民（N = 2189）进行了一项具有全国代表性的横断面调查，调查内容包括他们感知到的邻里社会凝聚力、COVID-19 和季节性流感疫苗接种意向、医疗保健获取途径、感知到的 COVID-19 或流感感染风险、孤独感以及对医生的信任度。我们使用双变量 probit 回归法来检验感知到的 NSC 与接种流感疫苗和 COVID-19 疫苗的意愿之间的关联，同时控制了一些受访者特征（如种族）。与信任相关的 NSC（对邻居的信任）与接种流感疫苗和 COVID-19 疫苗的意愿呈正相关。较高的关系型 NSC（认为邻里关系紧密）与接种 COVID-19 疫苗的意愿呈正相关，而较高的价值型 NSC（认为邻里价值观相同）与接种 COVID-19 疫苗的意愿呈负相关。医疗服务的可及性、感知到的感染风险（COVID-19 或流感）以及对医生的信任与接种这两种病毒疫苗的意愿呈正相关：结论：在后大流行病时代，美国成年人中较高的信任相关性和关系相关性、感知到的NSC（疫苗依赖性）、较高的医疗保健可及性、较高的感知感染风险以及对医生的较高信任度与较高的流感和COVID-19疫苗接种意愿有关，而较高的基于价值的NSC与较低的COVID-19疫苗接种意愿有关。因此，NSC 的特定方面、获得医疗保健的障碍、关于感染风险的错误信息以及对医疗的不信任可能会影响个人接种疫苗的意愿和最终决定。

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引用次数: 0

Ikigai and use of preventive healthcare services in Germany Ikigai 和德国预防保健服务的使用情况。

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2024-10-29 DOI: 10.1016/j.ypmed.2024.108159

André Hajek , Angelina R. Sutin , Antonio Terracciano , Martina Luchetti , Yannick Stephan , Karl Peltzer , Hans-Helmut König

Objective

This study examined the association between ikigai (a Japanese concept akin to purpose in life or a rationale for existence) and use of preventive healthcare services.

Methods

Data were gathered in August and September of 2023 from a quota-based sample of 5000 individuals living in Germany (18 to 74 years). This sampling ensured representation across gender, age groups, and federal states to reflect the adult population of Germany. The recently validated German version of the Ikigai-9 scale (Ikigai-9-G) was used to assess ikigai. Outcomes were regular cancer screenings, flu vaccination, and routine health check-ups. Multiple logistic regressions were used.

Results

Ikigai was associated with higher odds of regular use of preventive healthcare services (regular flu vaccinations: OR = 1.01, 95 % CI: 1.002 to 1.02; regular cancer screenings: OR = 1.01, 95 % CI: 1.004 to 1.02; routine health check-ups: OR = 1.02, 95 % CI: 1.01 to 1.03), adjusting for sociodemographic, lifestyle, and health-related factors. The association between ikigai and preventive healthcare was not moderated by gender, age, or education.

Conclusion

Higher ikigai is associated with preventive health measures, independent of key covariates. These findings are consistent with the literature on ikigai and better health-related outcomes and subjective well-being. Ikigai may help point to new ways to counter the low use of preventive services in Germany.

研究目的本研究探讨了 "ikigai"（一种类似于生活目的或存在理由的日本概念）与使用预防性医疗服务之间的关系：数据收集于 2023 年 8 月和 9 月，从居住在德国的 5000 名个人（18 至 74 岁）中进行配额抽样。这种抽样确保了不同性别、年龄组和联邦州的代表性，以反映德国的成年人口。采用最近验证的德文版 Ikigai-9 量表（Ikigai-9-G）来评估 ikigai。结果包括定期癌症筛查、流感疫苗接种和常规健康检查。研究采用了多重逻辑回归：结果：Ikigai 与较高的定期使用预防性医疗保健服务的几率相关（定期接种流感疫苗：OR = 1.01，95 % CI：1.002 至 1.02；定期进行癌症筛查：OR=1.01，95 % CI：1.004 至 1.02；常规健康检查：OR=1.02，95 % CI：1.01 至 1.03），并对社会人口、生活方式和健康相关因素进行了调整。ikigai与预防性保健之间的关系不受性别、年龄或教育程度的影响：结论：较高的ikigai与预防性保健措施相关，不受主要协变量的影响。这些发现与有关 "ikigai "与更好的健康相关结果和主观幸福感的文献相一致。在德国，Ikigai 可能有助于找到新的方法来应对预防性服务使用率低的问题。

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引用次数: 0

Response to “National bowel cancer screening programs: The Emperor's new clothes!” 回应 "国家肠癌筛查计划：皇帝的新衣！"

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2024-10-28 DOI: 10.1016/j.ypmed.2024.108156

Joachim Worthington

引用次数: 0

National bowel cancer screening programs: The Emperor's new clothes! 国家肠癌筛查计划：皇帝的新衣

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2024-10-28 DOI: 10.1016/j.ypmed.2024.108157

Alain Braillon

引用次数: 0

Association of watching sports games with subsequent health and well-being among adults in Japan: An outcome-wide longitudinal approach 日本成年人观看体育比赛与日后健康和幸福的关系：全结果纵向方法。

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2024-10-20 DOI: 10.1016/j.ypmed.2024.108154

Ryoko Kawakami , Naruki Kitano , Yuya Fujii , Takashi Jindo , Yuko Kai , Takashi Arao

Objective

Although the health benefits of playing sports are well-known, the association between watching sports and health is not well understood. We examined the longitudinal association of watching sports with 20 different health and well-being outcomes.

Methods

Three-wave cohort data from 6327 adults (4851 workers) in the Meiji Yasuda LifeStyle study were used to draw causal inferences. We assessed the frequency of watching sports games on media or in-person using a self-reported questionnaire in 2018. Outcomes, including health behaviors, physical, mental, and work-related outcomes, were evaluated in 2019. In 2017, sociodemographic factors, prior exposure, and outcome values were evaluated and used as covariates. Three different statistical models (logistic, modified Poisson, or linear regression) were used according to the nature of the outcome variable.

Results

Watching sports on media had a favorable dose-response association with a lower risk of becoming physically inactive and skipping breakfast, as well as higher happiness (p for trend < 0.05). Conversely, watching sports on media had an adverse dose-response association with higher body mass index and increased risks of developing hypertension and diabetes (p for trend < 0.05). Watching sports in-person had a dose-response association with lower risks of exhibiting the precontemplation stage of health behavior change, moderate/severe psychological distress, and dyslipidemia (p for trend < 0.05).

Conclusions

Despite the observed detrimental association between watching sports and cardiometabolic health, which should be interpreted cautiously and studied further, the study findings suggest that watching sports could be a new modifiable protective factor for developing healthy lifestyles and improving mental well-being.

目的：虽然参加体育运动对健康的益处众所周知，但观看体育比赛与健康之间的关系却不甚了解。我们研究了观看体育比赛与 20 种不同的健康和幸福结果之间的纵向联系：方法：我们利用明治安田生活方式研究中 6327 名成年人（4851 名工人）的三波队列数据进行因果推论。我们使用自我报告问卷评估了 2018 年通过媒体或亲自观看体育比赛的频率。2019年对结果进行了评估，包括健康行为、身体、精神和工作相关结果。2017 年，对社会人口学因素、先前接触情况和结果值进行了评估，并将其作为协变量。根据结果变量的性质，采用了三种不同的统计模型（逻辑模型、修正泊松模型或线性回归模型）：结果：在媒体上观看体育比赛与降低不运动和不吃早餐的风险以及提高幸福感有良好的剂量反应关系（趋势 p < 0.05）。相反，在媒体上观看体育比赛与体重指数升高、高血压和糖尿病发病风险升高有不利的剂量反应关系（趋势 p < 0.05）。亲自观看体育比赛与健康行为改变的前考虑阶段、中度/重度心理困扰和血脂异常的风险较低呈剂量反应关系（p为趋势 < 0.05）：尽管观察到观看体育比赛与心血管代谢健康之间存在不利的关联，对此应谨慎解释并进一步研究，但研究结果表明，观看体育比赛可能是发展健康生活方式和改善心理健康的一个新的可调节保护因素。

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引用次数: 0

Association between self-reported child maltreatment and risk of hospital-treated infectious diseases in middle-aged and older adults: A UK Biobank cohort study 中老年人自我报告的儿童虐待与医院治疗传染病风险之间的关系：英国生物库队列研究。

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2024-10-19 DOI: 10.1016/j.ypmed.2024.108153

Yifang Huang , Ruilang Lin , Wenhao Wang , Lulu Pan , Chen Huang , Yongfu Yu , Guoyou Qin , Zhijun Bao , Xueying Zheng

Objective

This study aimed to explore the association between child maltreatment and hospital-treated infectious diseases in middle-aged and older adults.

Methods

145,151 participants aged 38–72 years from the UK Biobank between 2006 and 2010 were enrolled and interviewed. Child maltreatment included five types: physical abuse, physical neglect, emotional abuse, emotional neglect, and sexual abuse. Patterns of maltreatment were identified using latent class analysis (LCA). Cox regression was employed to estimate the associations between child maltreatment (number of types, individual types, and patterns) and infectious diseases. Further, we evaluated potential mediators using mediation analysis.

Results

Over a median follow-up of 13.4 years, 22,688 participants (12.26 per 1000 person-years) were hospitalized for an infectious disease. Participants reporting any maltreatment had elevated infectious diseases risk (HR 1.18, 95 % CI: 1.15–1.21) than those without maltreatment. A dose-response relationship was observed between the number of maltreatment types and infectious disease (one, HR 1.09 [95 % CI 1.06–1.13]; two, HR 1.17 [95 % CI 1.12–1.23]; three to five, HR 1.48 [95 %CI 1.41–1.55]; P_trend < 0.001). Each type of maltreatment was associated with increased infectious diseases risk. LCA identified four patterns (low maltreatment, child neglect, child abuse, and poly-maltreatment), with those who experienced poly-maltreatment exhibiting the highest infectious diseases risk (HR 1.51, 95 % CI: 1.43–1.59). The association between child maltreatment and infectious diseases was mediated by C-reactive protein, phenotypic age acceleration, loneliness, psychiatric disorders, and unhealthy lifestyles.

Conclusions

Child maltreatment may increase susceptibility to a broad spectrum of infectious diseases in adulthood, highlighting the need for early-life maltreatment prevention policies.

研究目的本研究旨在探讨中老年人中儿童虐待与医院治疗的传染病之间的关系。方法：对 2006 年至 2010 年间英国生物库中年龄在 38-72 岁之间的 145,151 名参与者进行了登记和访谈。儿童虐待包括五种类型：身体虐待、身体忽视、情感虐待、情感忽视和性虐待。采用潜类分析（LCA）确定了虐待模式。采用 Cox 回归估算儿童虐待（类型数量、个体类型和模式）与传染病之间的关联。此外，我们还利用中介分析评估了潜在的中介因素：在 13.4 年的中位随访期间，22,688 名参与者（每千人年 12.26 人）因感染传染病而住院。与未受过虐待的参与者相比，报告受过虐待的参与者患传染病的风险更高（HR 1.18，95 % CI：1.15-1.21）。虐待类型的数量与传染病之间存在剂量反应关系（一次，HR 1.09 [95 % CI 1.06-1.13]；两次，HR 1.17 [95 % CI 1.12-1.23]；三次至五次，HR 1.48 [95 %CI 1.41-1.55]；Ptrend 结论：儿童受虐待可能会增加成年后对多种传染病的易感性，因此需要制定早期虐待预防政策。

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引用次数: 0

Fish oil supplementation, genetic susceptibility and risk of new-onset hypertension 补充鱼油、遗传易感性和新发高血压的风险。

IF 4.3 2区医学 Q1 MEDICINE, GENERAL & INTERNAL

Preventive medicine

Pub Date : 2024-10-16 DOI: 10.1016/j.ypmed.2024.108152

Zhi-Hao Li , Wei-Qi Song , Cheng-Shen Qiu , Hong-Min Li , Xu-Lian Tang , Dong Shen , Pei-Dong Zhang , Xi-Ru Zhang , Jiao-Jiao Ren , Jian Gao , Wen-Fang Zhong , Dan Liu , Ying-Jun Chen , Pei-Liang Chen , Qing-Mei Huang , Chen Mao

Objectives

The risk of new-onset hypertension is influenced by habitual fish oil supplementation, but whether the association is modified by genetic predisposition is unknown.

Methods

A total of 213,604 participants without hypertension were identified at baseline from the UK Biobank between 2006 and 2010. The weighted polygenetic risk score (PRS) comprising 118 identified single-nucleotide polymorphisms (SNPs) was used to quantify genetic susceptibility. Cox regression models were applied to determine the association between fish oil supplementation, PRS, and hypertension and evaluate the effect modification of genetic susceptibility.

Results

During a median follow-up of 13.8 years, 18,498 new-onset hypertension cases were identified. Approximately 30.6 % (65,452) of participants were habitual fish oil users. The hazard ratio (HR) of habitual fish oil users for hypertension was 0.94 (95 % confidence interval [CI], 0.91–0.98). Fish oil nonusers with a high genetic risk had an increased risk of hypertension (HR, 1.52; 95 % CI, 1.41–1.64) compared to fish oil users with a low genetic risk. In addition, an interaction on the additive scale between the fish oil use and intermediate or high levels of genetic susceptibility was observed. The interactive effects accounted for approximately 7 % and 22 % of the risk of developing hypertension, respectively.

Conclusions

This cohort study indicates regular fish oil supplementation could be beneficial in preventing hypertension, particularly among individuals with intermediate or high genetic susceptibility on an additive scale.

目的：新发高血压的风险受习惯性补充鱼油的影响，但遗传易感性是否会改变这种关联尚不清楚：习惯性补充鱼油会影响新发高血压的风险，但这种关联是否会因遗传易感性而改变尚不清楚：方法：2006 年至 2010 年间，从英国生物库（UK Biobank）中确定了 213 604 名无高血压的基线参与者。由 118 个已识别的单核苷酸多态性（SNPs）组成的加权多基因风险评分（PRS）用于量化遗传易感性。采用 Cox 回归模型确定鱼油补充、PRS 和高血压之间的关系，并评估遗传易感性的影响：在中位 13.8 年的随访期间，共发现 18,498 例新发高血压病例。约 30.6% 的参与者（65 452 人）习惯使用鱼油。惯用鱼油者患高血压的危险比（HR）为 0.94（95 % 置信区间 [CI]，0.91-0.98）。与遗传风险低的鱼油使用者相比，遗传风险高的非鱼油使用者患高血压的风险更高（HR，1.52；95 % CI，1.41-1.64）。此外，还观察到使用鱼油与中度或高度遗传易感性之间的交互作用。交互效应分别占高血压发病风险的约 7% 和 22%：这项队列研究表明，定期补充鱼油有利于预防高血压，尤其是在中度或高度遗传易感性个体中。

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引用次数: 0