Mikołaj Pietrzak, J. Pasek, S. Szajkowski, Karol Szyluk, G. Cieślar
Abstract Introduction Recently, increased frequency of chronic leg ulcers has been observed. The aim of the study was to compare therapeutic efficacy of combined physical therapy to topical hyperbaric oxygen therapy in the treatment of venous leg ulcers. Materials and Methods Participants included 36 patients (14 females and 22 males) between 18 and 80 years of age with chronic venous leg ulcers. They were randomly divided into two study groups. Group I underwent topical hyperbaric oxygen therapy; group II underwent combined physical therapy. Before and after the therapeutic cycle (15 procedures) measurement of ulceration size by planimetry and analysis of laboratory parameters of blood was performed. Results In both groups, a statistically significant reduction of ulcer surface area was obtained (25.11±17.8cm2 to 16.93±13.89cm2, p=0.000196) vs. (34.17±14.82cm2 to 23.99±15.15cm2, p=0.004337). Blood morphology revealed a statistically significant reduction in patients from group II who underwent combined physical therapy (p=0.01). In both groups, statistically significant reduction of fibrinogen level (p=0.01 and p<0.001), and total protein level (p=0.01) was achieved. In group II reduction of the inflammation marker C-reactive protein (CRP) was noted. Conclusions Topical hyperbaric oxygen therapy and combined physical therapy had statistically significant effects on the reduction of surface area of treated venous leg ulcers. The changes in morphological and biochemical parameters may indicate the anti-inflammatory and anti-clotting action effects of combined physical therapy.
{"title":"Is combined physical therapy more effective than topical hyperbaric oxygen therapy in the treatment of venous leg ulcers? Preliminary study","authors":"Mikołaj Pietrzak, J. Pasek, S. Szajkowski, Karol Szyluk, G. Cieślar","doi":"10.2478/ahem-2022-0023","DOIUrl":"https://doi.org/10.2478/ahem-2022-0023","url":null,"abstract":"Abstract Introduction Recently, increased frequency of chronic leg ulcers has been observed. The aim of the study was to compare therapeutic efficacy of combined physical therapy to topical hyperbaric oxygen therapy in the treatment of venous leg ulcers. Materials and Methods Participants included 36 patients (14 females and 22 males) between 18 and 80 years of age with chronic venous leg ulcers. They were randomly divided into two study groups. Group I underwent topical hyperbaric oxygen therapy; group II underwent combined physical therapy. Before and after the therapeutic cycle (15 procedures) measurement of ulceration size by planimetry and analysis of laboratory parameters of blood was performed. Results In both groups, a statistically significant reduction of ulcer surface area was obtained (25.11±17.8cm2 to 16.93±13.89cm2, p=0.000196) vs. (34.17±14.82cm2 to 23.99±15.15cm2, p=0.004337). Blood morphology revealed a statistically significant reduction in patients from group II who underwent combined physical therapy (p=0.01). In both groups, statistically significant reduction of fibrinogen level (p=0.01 and p<0.001), and total protein level (p=0.01) was achieved. In group II reduction of the inflammation marker C-reactive protein (CRP) was noted. Conclusions Topical hyperbaric oxygen therapy and combined physical therapy had statistically significant effects on the reduction of surface area of treated venous leg ulcers. The changes in morphological and biochemical parameters may indicate the anti-inflammatory and anti-clotting action effects of combined physical therapy.","PeriodicalId":20347,"journal":{"name":"Postȩpy higieny i medycyny doświadczalnej","volume":"76 1","pages":"199 - 208"},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69110102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahar Ghazanfari, S. Mohammadi, S. Rezaie, S. Khodavaisy, A. Samadani
Abstract Introduction Therapeutic methods are very important in the prevalence of opportunistic fungal infections, which are an important cause of human diseases. In this study, air pollution agents that are in direct contact with microorganisms, and the effects of carbon sources using CO2 and MTBE on growth of fungi, and particularly the evaluation of changes in the expression of interfering genes in susceptibility and drug resistance in these fungi, were investigated. Materials and Methods Collecting samples and isolating Candida glabrata and Candida albicans with phenotypic methods were accomplished. We then evaluated the minimum inhibitory concentration (MIC) with the M27A4 protocol of CLSI. We adjusted 20 strains of C. albicans and 10 strains of C. glabrata whose sensitivity was evaluated in the MIC test with 5% CO2 and 5mg/ml methyl tert-butyl ether (MTBE) considered as air pollutants, and followed by re-evaluating MIC testing to separate azole-resistant strains. Interfering agents were also considered. Results Upregulation of some genes on the two mentioned yeasts had led to drug resistance in them; they were previously sensitive to both drugs. Correspondingly, 41% of C. glabrata samples in sputum showed sensitivity to these drugs. Upregulation of ERG11 (71%) and EPA1 (90%) were observed in resistant strains. Upregulation of genes associated with aspartate proteins and downregulation of SAP3 genes were recognized in C. glabrata in sputum and a 15% downregulation of bronchoalveolar lavage (BAL) isolate and 50% upregulation of SAP1 gene in C. albicans sensitive samples were observed and compared to fluconazole and itraconazole with the oral and joint sources. Remarkably, decreased SAP2 expression in oral sources and a 60% increase in resistant strains in C. albicans were observed. The downregulation of SAP3 expression showed in the joint samples. An increase in HWP1 expression (30%) was noted in isolated and drug-sensitive samples at the sputum and BAL source. CDR1 expression was increased in MTBE-affected species; however, it decreased in the vicinity of CT. Conclusions Air pollutants such as CO2 and MTBE eventually caused drug resistance in Candida, which can be one of the causes of drug resistance in candidiasis infections.
{"title":"The association of air pollutants (CO2, MTBE) on Candida albicans and Candida glabrata drug resistance","authors":"Sahar Ghazanfari, S. Mohammadi, S. Rezaie, S. Khodavaisy, A. Samadani","doi":"10.2478/ahem-2022-0004","DOIUrl":"https://doi.org/10.2478/ahem-2022-0004","url":null,"abstract":"Abstract Introduction Therapeutic methods are very important in the prevalence of opportunistic fungal infections, which are an important cause of human diseases. In this study, air pollution agents that are in direct contact with microorganisms, and the effects of carbon sources using CO2 and MTBE on growth of fungi, and particularly the evaluation of changes in the expression of interfering genes in susceptibility and drug resistance in these fungi, were investigated. Materials and Methods Collecting samples and isolating Candida glabrata and Candida albicans with phenotypic methods were accomplished. We then evaluated the minimum inhibitory concentration (MIC) with the M27A4 protocol of CLSI. We adjusted 20 strains of C. albicans and 10 strains of C. glabrata whose sensitivity was evaluated in the MIC test with 5% CO2 and 5mg/ml methyl tert-butyl ether (MTBE) considered as air pollutants, and followed by re-evaluating MIC testing to separate azole-resistant strains. Interfering agents were also considered. Results Upregulation of some genes on the two mentioned yeasts had led to drug resistance in them; they were previously sensitive to both drugs. Correspondingly, 41% of C. glabrata samples in sputum showed sensitivity to these drugs. Upregulation of ERG11 (71%) and EPA1 (90%) were observed in resistant strains. Upregulation of genes associated with aspartate proteins and downregulation of SAP3 genes were recognized in C. glabrata in sputum and a 15% downregulation of bronchoalveolar lavage (BAL) isolate and 50% upregulation of SAP1 gene in C. albicans sensitive samples were observed and compared to fluconazole and itraconazole with the oral and joint sources. Remarkably, decreased SAP2 expression in oral sources and a 60% increase in resistant strains in C. albicans were observed. The downregulation of SAP3 expression showed in the joint samples. An increase in HWP1 expression (30%) was noted in isolated and drug-sensitive samples at the sputum and BAL source. CDR1 expression was increased in MTBE-affected species; however, it decreased in the vicinity of CT. Conclusions Air pollutants such as CO2 and MTBE eventually caused drug resistance in Candida, which can be one of the causes of drug resistance in candidiasis infections.","PeriodicalId":20347,"journal":{"name":"Postȩpy higieny i medycyny doświadczalnej","volume":"76 1","pages":"243 - 253"},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48701413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joanna Chrobak-Bień, M. Włodarczyk, A. Ignaczak, A. Lakoma, E. Małecka-Panas, A. Gąsiorowska, Ewa Borowiak
Abstract Introduction Inflammatory bowel disease (IBD) is a group of chronic inflammatory diseases of the gastrointestinal tract with relapsing-remitting episodes that are very burdensome for the patient. Understanding the sociodemographic factors that affect a patient’s quality of life helps us to better understand the behavior and life circumstances of the patient as well as the patient’s ability to cope with the stresses caused by IBD. Aim The aim of the study was to identify factors that affect the quality of life of patients with IBD. Material and methods The study involved 100 patients with confirmed IBD (50 subjects with Crohn’s disease and 50 subjects with ulcerative colitis). Women constituted 45% (n=45) of the study group, while the remaining 55% (n=55) of the group were men. The mean age of the respondents participating in the study was 37.27±13.38. The youngest patient was 20 years old and the oldest was 76. The respondents were treated at the Department of General and Colorectal Surgery and at the Department of Digestive Tract Diseases (both at Medical University in Łódź, Poland). Data were collected using the SF-36 general questionnaire, the IBDQ specific questionnaire, and the original author’s questionnaire. Participation in the study was anonymous and voluntary. A significance level of 0.05 was adopted in the statistical analysis. Results The study showed that the quality of life of IBD patients is reduced. The psychosocial factors influencing the quality of life of IBD patients include education, place of residence, professional activity, having a spouse, and lack of surgical intervention. However, no significant relationship was found between the respondents’ gender and age and their quality of life in any of the domains of the SF-36 and IBDQ questionnaire. Conclusions The occurrence of IBD, a chronic and incurable disease, reduces the quality of life of those patients. However, a higher level of education, living in a larger community, and increased physical activity all have a positive impact on the quality of life of patients with IBD.
{"title":"The relationship of quality of life and selected sociodemographic factors in patients with inflammatory bowel disease","authors":"Joanna Chrobak-Bień, M. Włodarczyk, A. Ignaczak, A. Lakoma, E. Małecka-Panas, A. Gąsiorowska, Ewa Borowiak","doi":"10.2478/ahem-2022-0003","DOIUrl":"https://doi.org/10.2478/ahem-2022-0003","url":null,"abstract":"Abstract Introduction Inflammatory bowel disease (IBD) is a group of chronic inflammatory diseases of the gastrointestinal tract with relapsing-remitting episodes that are very burdensome for the patient. Understanding the sociodemographic factors that affect a patient’s quality of life helps us to better understand the behavior and life circumstances of the patient as well as the patient’s ability to cope with the stresses caused by IBD. Aim The aim of the study was to identify factors that affect the quality of life of patients with IBD. Material and methods The study involved 100 patients with confirmed IBD (50 subjects with Crohn’s disease and 50 subjects with ulcerative colitis). Women constituted 45% (n=45) of the study group, while the remaining 55% (n=55) of the group were men. The mean age of the respondents participating in the study was 37.27±13.38. The youngest patient was 20 years old and the oldest was 76. The respondents were treated at the Department of General and Colorectal Surgery and at the Department of Digestive Tract Diseases (both at Medical University in Łódź, Poland). Data were collected using the SF-36 general questionnaire, the IBDQ specific questionnaire, and the original author’s questionnaire. Participation in the study was anonymous and voluntary. A significance level of 0.05 was adopted in the statistical analysis. Results The study showed that the quality of life of IBD patients is reduced. The psychosocial factors influencing the quality of life of IBD patients include education, place of residence, professional activity, having a spouse, and lack of surgical intervention. However, no significant relationship was found between the respondents’ gender and age and their quality of life in any of the domains of the SF-36 and IBDQ questionnaire. Conclusions The occurrence of IBD, a chronic and incurable disease, reduces the quality of life of those patients. However, a higher level of education, living in a larger community, and increased physical activity all have a positive impact on the quality of life of patients with IBD.","PeriodicalId":20347,"journal":{"name":"Postȩpy higieny i medycyny doświadczalnej","volume":"76 1","pages":"111 - 116"},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47822453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract It is commonly pointed out that enteric microbiota have a significant impact on the behavioral and neurophysiological parameters relevant to brain-gut axis disorders. Accordingly, many data have demonstrated that probiotics can alter the central nervous system function via this gut-brain axis and commensal bacteria consumption can ameliorate stress-related neuropsychiatric disorders. Thus, modulating the enteric microbiota is increasingly considered a new therapeutic approach for these disorders, although so far there is a lack of reliable pre-clinical and clinical data confirming the usefulness of probiotics in the treatment of affective disorders. In this review, we discuss various mechanisms linking specific probiotic bacteria with behaviors related to anhedonia and the exact mechanisms of their action, including data provided by using animal models and tests. Finally, we point to potential clinical impact resulting from future studies investigating the gut-brain axis activity with respect to the efficacy of probiotic treatment of mental disorders.
{"title":"What do experimental animal models of mood disorders tell clinicians about influence of probiotics on the gut-brain axis?","authors":"N. Staniak, Ewa Piaseczna-Spitaleri, G. Biała","doi":"10.2478/ahem-2022-0042","DOIUrl":"https://doi.org/10.2478/ahem-2022-0042","url":null,"abstract":"Abstract It is commonly pointed out that enteric microbiota have a significant impact on the behavioral and neurophysiological parameters relevant to brain-gut axis disorders. Accordingly, many data have demonstrated that probiotics can alter the central nervous system function via this gut-brain axis and commensal bacteria consumption can ameliorate stress-related neuropsychiatric disorders. Thus, modulating the enteric microbiota is increasingly considered a new therapeutic approach for these disorders, although so far there is a lack of reliable pre-clinical and clinical data confirming the usefulness of probiotics in the treatment of affective disorders. In this review, we discuss various mechanisms linking specific probiotic bacteria with behaviors related to anhedonia and the exact mechanisms of their action, including data provided by using animal models and tests. Finally, we point to potential clinical impact resulting from future studies investigating the gut-brain axis activity with respect to the efficacy of probiotic treatment of mental disorders.","PeriodicalId":20347,"journal":{"name":"Postȩpy higieny i medycyny doświadczalnej","volume":"76 1","pages":"380 - 394"},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47530353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Radwan-Oczko, Joanna E. Owczarek-Drabińska, A. Szczygielska, M. Szczepaniak, Irena Duś-Ilnicka
Abstract Introduction In recent years, interest in human papillomavirus infections as a causative factor in epithelial cancer development has grown. Literature indicates that HPV involvement in malignant transformations in oral mucosa can vary significantly, from 0 up to 87%. The aim of our study was to detect the prevalence of salivary HPV infection among generally healthy adults. Materials and Methods The examination involved 139 patients, from whom 139 whole, 1.5ml saliva samples were obtained. HPV DNA was detected by the nested PCR technique. To visualize the PCR products electrophoresis reactions were carried out. Results Sample analysis showed that DNA for HPV was detected in 14 patients: 11 positive results were obtained from men, and 3 from women. This yields a high infection rate: 10.07%. Conclusions The HPV prevalence in the male group was more than twice as high as in the female group. Also, subclinical oral HPV infection was detected more frequently in young (19–39 years old) and older (=>60 years old) adults.
{"title":"Salivary HPV infection in healthy people","authors":"M. Radwan-Oczko, Joanna E. Owczarek-Drabińska, A. Szczygielska, M. Szczepaniak, Irena Duś-Ilnicka","doi":"10.2478/ahem-2022-0016","DOIUrl":"https://doi.org/10.2478/ahem-2022-0016","url":null,"abstract":"Abstract Introduction In recent years, interest in human papillomavirus infections as a causative factor in epithelial cancer development has grown. Literature indicates that HPV involvement in malignant transformations in oral mucosa can vary significantly, from 0 up to 87%. The aim of our study was to detect the prevalence of salivary HPV infection among generally healthy adults. Materials and Methods The examination involved 139 patients, from whom 139 whole, 1.5ml saliva samples were obtained. HPV DNA was detected by the nested PCR technique. To visualize the PCR products electrophoresis reactions were carried out. Results Sample analysis showed that DNA for HPV was detected in 14 patients: 11 positive results were obtained from men, and 3 from women. This yields a high infection rate: 10.07%. Conclusions The HPV prevalence in the male group was more than twice as high as in the female group. Also, subclinical oral HPV infection was detected more frequently in young (19–39 years old) and older (=>60 years old) adults.","PeriodicalId":20347,"journal":{"name":"Postȩpy higieny i medycyny doświadczalnej","volume":"76 1","pages":"143 - 148"},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69109910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Wilczyńska, J. Ziętek, O. Teodorowski, Ł. Adaszek
Abstract Encephalitzoon spp. are microsporidia, and intracellular opportunistic pathogens. The hosts of these pathogens include vertebrates, invertebrates, and certain protozoa. In people microsporidia may be opportunistic pathogens for immunocompromised patients (with AIDS or after organ transplantation). Infection with these microorganisms was also described in persons with diarrhea and corneal diseases. The species causing rare infections in humans, Encephalitozooncuniculi, had previously been described from animal hosts. However, several new microsporidial species, including E. intestinalis and E. hellem, have been discovered in humans, raising the question of their natural origin. Vertebrate animals are now identified as hosts for all three microsporidial species infecting humans, implying a zoonotic nature of these microorganisms. Molecular studies have identified phenotypic and/or genetic variability within these species, indicating that they are not uniform, and have allowed the question of their zoonotic potential to be addressed. The focus of this review is to present the zoonotic potential of E. intestinalis, E. cuniculi, and E. hellem.
{"title":"Encephalitozoon spp. as a potential human pathogen","authors":"Anna Wilczyńska, J. Ziętek, O. Teodorowski, Ł. Adaszek","doi":"10.2478/ahem-2022-0005","DOIUrl":"https://doi.org/10.2478/ahem-2022-0005","url":null,"abstract":"Abstract Encephalitzoon spp. are microsporidia, and intracellular opportunistic pathogens. The hosts of these pathogens include vertebrates, invertebrates, and certain protozoa. In people microsporidia may be opportunistic pathogens for immunocompromised patients (with AIDS or after organ transplantation). Infection with these microorganisms was also described in persons with diarrhea and corneal diseases. The species causing rare infections in humans, Encephalitozooncuniculi, had previously been described from animal hosts. However, several new microsporidial species, including E. intestinalis and E. hellem, have been discovered in humans, raising the question of their natural origin. Vertebrate animals are now identified as hosts for all three microsporidial species infecting humans, implying a zoonotic nature of these microorganisms. Molecular studies have identified phenotypic and/or genetic variability within these species, indicating that they are not uniform, and have allowed the question of their zoonotic potential to be addressed. The focus of this review is to present the zoonotic potential of E. intestinalis, E. cuniculi, and E. hellem.","PeriodicalId":20347,"journal":{"name":"Postȩpy higieny i medycyny doświadczalnej","volume":"271 1","pages":"54 - 61"},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69110145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agnieszka Owczarczyk-Saczonek, Marta Kasprowicz-Furmańczyk, M. Krajewska-Włodarczyk, J. Szepietowski
Abstract Psoriasis is one of the most common chronic inflammatory skin diseases, constituting a significant health and socioeconomic problem. Despite numerous therapeutic options, the results of treatment often remain insufficient. This may be due to the lack of compliance with medical prescriptions and patients’ limited knowledge of their disease. Psoriatic patient's skin well-being is affected by many factors, including lifestyle. The course of the disease is affected by obesity, improper diet, and stimulants. Often these factors coexist. Excessive weight gain in psoriasis can be caused by a decrease in physical activity, caused by feelings of social stigma, coexistence of psoriatic arthritis, depression, and increased alcohol consumption. Several studies have confirmed that the average fat, protein, and calorie content in the diet of a patient with psoriasis are above the recommended norms. On the other hand, adhering to a low calorie, reducing diet results in a clinically significant improvement in the Psoriasis Area Severity Index (PASI) and patients’ quality of life (i.e., reduction of Dermatology Life Quality Index [DLQI]). Weight reduction caused by diet and exercise reduces the severity of skin lesions, even in people who have not achieved improvement after general treatment. Therefore, it is important to educate the patient about the nature of the disease at the very beginning of treatment. Patients with moderate to severe forms of the disease are predisposed to the development of cardiovascular diseases, obesity, diabetes, and anxiety. That is why plaque psoriasis requires a comprehensive treatment and a holistic approach to the patient.
{"title":"Effect of diet and weight loss on the severity of psoriasis","authors":"Agnieszka Owczarczyk-Saczonek, Marta Kasprowicz-Furmańczyk, M. Krajewska-Włodarczyk, J. Szepietowski","doi":"10.2478/ahem-2022-0039","DOIUrl":"https://doi.org/10.2478/ahem-2022-0039","url":null,"abstract":"Abstract Psoriasis is one of the most common chronic inflammatory skin diseases, constituting a significant health and socioeconomic problem. Despite numerous therapeutic options, the results of treatment often remain insufficient. This may be due to the lack of compliance with medical prescriptions and patients’ limited knowledge of their disease. Psoriatic patient's skin well-being is affected by many factors, including lifestyle. The course of the disease is affected by obesity, improper diet, and stimulants. Often these factors coexist. Excessive weight gain in psoriasis can be caused by a decrease in physical activity, caused by feelings of social stigma, coexistence of psoriatic arthritis, depression, and increased alcohol consumption. Several studies have confirmed that the average fat, protein, and calorie content in the diet of a patient with psoriasis are above the recommended norms. On the other hand, adhering to a low calorie, reducing diet results in a clinically significant improvement in the Psoriasis Area Severity Index (PASI) and patients’ quality of life (i.e., reduction of Dermatology Life Quality Index [DLQI]). Weight reduction caused by diet and exercise reduces the severity of skin lesions, even in people who have not achieved improvement after general treatment. Therefore, it is important to educate the patient about the nature of the disease at the very beginning of treatment. Patients with moderate to severe forms of the disease are predisposed to the development of cardiovascular diseases, obesity, diabetes, and anxiety. That is why plaque psoriasis requires a comprehensive treatment and a holistic approach to the patient.","PeriodicalId":20347,"journal":{"name":"Postȩpy higieny i medycyny doświadczalnej","volume":"76 1","pages":"450 - 460"},"PeriodicalIF":0.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69110382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Glibowski, Katarzyna Iłowiecka, Karolina Środek
Abstract Vitamin D is extremely important for the proper functioning of the body. The most commonly known role of vitamin D is its participation in regulation of calcium-phosphate metabolism and bone mineralization. This role is crucial in the prevention of rickets in children and osteoporosis in the elderly. In recent years, numerous studies have confirmed the pleiotropic effects of vitamin D. Proper vitamin D levels in blood have a positive effect on overall health, thus reducing the risk of many diseases. Vitamin D plays, inter alia, a positive role in some diseases of the gastrointestinal tract (inflammatory bowel disease), nervous system (Parkinson disease, Alzheimer disease), and cardiovascular disease (atherosclerosis). Additionally, its positive protective effect in the case of neoplastic and immunological diseases has been noted. Some studies also confirm the relationship of vitamin D deficiency to obesity and depression. In the event of these diseases, it is possible to prevent disease and support the process of treatment by maintaining appropriate levels of 25(OH)D in the blood. Besides, sufficient blood vitamin D levels reduces the risk of developing respiratory tract infections and suppresses cytokine storm, which is responsible for most COVID-19 deaths. The aim of the study was to present the current state of knowledge regarding the role of vitamin D in the human body, especially in the context of the impact of its abnormal level on the development of various diseases.
{"title":"Health consequences of vitamin D deficiency in the human body","authors":"P. Glibowski, Katarzyna Iłowiecka, Karolina Środek","doi":"10.2478/ahem-2021-0045","DOIUrl":"https://doi.org/10.2478/ahem-2021-0045","url":null,"abstract":"Abstract Vitamin D is extremely important for the proper functioning of the body. The most commonly known role of vitamin D is its participation in regulation of calcium-phosphate metabolism and bone mineralization. This role is crucial in the prevention of rickets in children and osteoporosis in the elderly. In recent years, numerous studies have confirmed the pleiotropic effects of vitamin D. Proper vitamin D levels in blood have a positive effect on overall health, thus reducing the risk of many diseases. Vitamin D plays, inter alia, a positive role in some diseases of the gastrointestinal tract (inflammatory bowel disease), nervous system (Parkinson disease, Alzheimer disease), and cardiovascular disease (atherosclerosis). Additionally, its positive protective effect in the case of neoplastic and immunological diseases has been noted. Some studies also confirm the relationship of vitamin D deficiency to obesity and depression. In the event of these diseases, it is possible to prevent disease and support the process of treatment by maintaining appropriate levels of 25(OH)D in the blood. Besides, sufficient blood vitamin D levels reduces the risk of developing respiratory tract infections and suppresses cytokine storm, which is responsible for most COVID-19 deaths. The aim of the study was to present the current state of knowledge regarding the role of vitamin D in the human body, especially in the context of the impact of its abnormal level on the development of various diseases.","PeriodicalId":20347,"journal":{"name":"Postȩpy higieny i medycyny doświadczalnej","volume":"75 1","pages":"947 - 958"},"PeriodicalIF":0.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69109902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Konrad Rekucki, Agnieszka Sławuta, M. Obremska, K. Madziarska
Abstract Patients on maintenance hemodialysis are a group with high cardiovascular risk, characterized by high arterial stiffness, which is considered a novel cardiovascular risk factor. Diabetes mellitus is both one of the leading causes of end-stage renal disease and a determinant of poor outcome in this group. The aim of the study was to examine carotid stiffness with high resolution echo-tracking in order to assess the influence of diabetes mellitus on arterial stiffness in this group. Ninety patients (47 F; 43 M) with end-stage renal disease on maintenance hemodialysis were divided into two subgroups: diabetic and nondiabetic (37 and 53 patients respectively). They underwent clinical examination, laboratory tests, and ultrasonographic carotid stiffness assessment both before and after hemodialysis. Local arterial stiffness parameters β, Ep, AC, and PWVβ were calculated. Patient survival was assessed after a 58-month-long follow-up. During the 58-month period 25 of these diabetic patients died, as did 18 non-diabetic patients. Diabetes mellitus was a risk factor for overall mortality among the group of hemodialysed patients. Patients who died from non-cardiovascular causes significantly more often suffered from diabetes mellitus than survivors. There were no statistically significant differences in local arterial stiffness between the groups. Local arterial stiffness in hemodialysed patients, assessed with high resolution echo-tracking, is not influenced by the presence of diabetes.
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Abstrakt Lipodystrofie to grupa chorób objawiających się zanikiem i/lub nieprawidłowym rozmieszczeniem tkanki tłuszczowej w organizmie człowieka. W związku z tym, że tkanka tłuszczowa jest narządem hormonalnie czynnym, jej niedobór doprowadza do powstania wielu zaburzeń metabolicznych i hormonalnych, wynikających w dużej mierze ze zmniejszonego wytwarzania leptyny, jednego z ważniejszych hormonów wydzielanych przez tkankę tłuszczową. Leptyna jest cytokiną, która po połączeniu z receptorem leptynowym uczestniczy przede wszystkim w regulacji ośrodka głodu, ale także wywołuje angiogenezę i stymuluje układ odpornościowy, przez stymulację wysp beta trzustki reguluje glikemię, działa protekcyjnie na układ kostny, wpływa na płodność, cykl menstruacyjny i ciążę, hamuje syntezę triglicerydów w wątrobie i tkance tłuszczowej oraz stymuluje lipolizę. W związku z tym uważa się, że to właśnie niedobór leptyny jest odpowiedzialny za zaburzenia metaboliczne powstałe w przebiegu lipodystrofii. Badania kliniczne wskazują na możliwość wykorzystania rekombinowanej leptyny – metreleptyny w celu uzupełnienia niedoboru hormonu. U pacjentów z różnymi typami lipodystrofii po zastosowaniu metreleptyny zaobserwowano normalizację poziomu glukozy, triglicerydów i cholesterolu frakcji HDL. Ponadto pacjenci sygnalizowali zmniejszenie apetytu i spadek BMI przy jednoczesnym braku istotnych działań niepożądanych leku. W związku z tym dopuszczono wykorzystanie metreleptyny w Stanach Zjednoczonych i Europie do leczenia chorych z niektórymi typami lipodystrofii. Natomiast zastosowanie leku w innych schorzeniach objawiających się zaburzeniami metabolicznymi jest w fazie badań klinicznych. Abstract Lipodystrophies are a group of diseases characterized by the disappearance and/or incorrect distribution of adipose tissue in the human body. Adipose tissue is a hormonally active organ and its deficiency causes many metabolic and hormonal disorders. These disorders result from reduced production of leptin, one of the most important hormones produced by adipose tissue. Leptin is a cytokine that binds to the leptin receptor and participates in the regulation of the hunger center, but also stimulates angiogenesis and the immune system; by stimulating pancreatic beta cells it regulates glycemia; protects the skeleton; affects fertility, menstrual cycle and pregnancy; inhibits synthesis triglycerides in the liver and adipose tissue and stimulates lipolysis. Therefore, it is postulated that leptin deficiency is responsible for the metabolic disorders that occur in lipodystrophy. Clinical trials indicate the possibility of using recombinant leptin – metreleptin to supplement the hormone deficiency. In patients with various types of lipodystrophy, normalization of glucose, triglycerides and HDL cholesterol levels was observed after the use of metreleptin. In addition, patients reported a decrease in appetite and, as a result, a decrease in BMI with no significant side effects of the drug. Accordin
{"title":"Zastosowanie leptyny rekombinowanej w leczeniu różnych typów lipodystrofii Treatment options with recombinant leptin in various types of lipodystrophy.","authors":"H. Hołysz, E. Totoń","doi":"10.2478/ahem-2021-0016","DOIUrl":"https://doi.org/10.2478/ahem-2021-0016","url":null,"abstract":"Abstrakt Lipodystrofie to grupa chorób objawiających się zanikiem i/lub nieprawidłowym rozmieszczeniem tkanki tłuszczowej w organizmie człowieka. W związku z tym, że tkanka tłuszczowa jest narządem hormonalnie czynnym, jej niedobór doprowadza do powstania wielu zaburzeń metabolicznych i hormonalnych, wynikających w dużej mierze ze zmniejszonego wytwarzania leptyny, jednego z ważniejszych hormonów wydzielanych przez tkankę tłuszczową. Leptyna jest cytokiną, która po połączeniu z receptorem leptynowym uczestniczy przede wszystkim w regulacji ośrodka głodu, ale także wywołuje angiogenezę i stymuluje układ odpornościowy, przez stymulację wysp beta trzustki reguluje glikemię, działa protekcyjnie na układ kostny, wpływa na płodność, cykl menstruacyjny i ciążę, hamuje syntezę triglicerydów w wątrobie i tkance tłuszczowej oraz stymuluje lipolizę. W związku z tym uważa się, że to właśnie niedobór leptyny jest odpowiedzialny za zaburzenia metaboliczne powstałe w przebiegu lipodystrofii. Badania kliniczne wskazują na możliwość wykorzystania rekombinowanej leptyny – metreleptyny w celu uzupełnienia niedoboru hormonu. U pacjentów z różnymi typami lipodystrofii po zastosowaniu metreleptyny zaobserwowano normalizację poziomu glukozy, triglicerydów i cholesterolu frakcji HDL. Ponadto pacjenci sygnalizowali zmniejszenie apetytu i spadek BMI przy jednoczesnym braku istotnych działań niepożądanych leku. W związku z tym dopuszczono wykorzystanie metreleptyny w Stanach Zjednoczonych i Europie do leczenia chorych z niektórymi typami lipodystrofii. Natomiast zastosowanie leku w innych schorzeniach objawiających się zaburzeniami metabolicznymi jest w fazie badań klinicznych. Abstract Lipodystrophies are a group of diseases characterized by the disappearance and/or incorrect distribution of adipose tissue in the human body. Adipose tissue is a hormonally active organ and its deficiency causes many metabolic and hormonal disorders. These disorders result from reduced production of leptin, one of the most important hormones produced by adipose tissue. Leptin is a cytokine that binds to the leptin receptor and participates in the regulation of the hunger center, but also stimulates angiogenesis and the immune system; by stimulating pancreatic beta cells it regulates glycemia; protects the skeleton; affects fertility, menstrual cycle and pregnancy; inhibits synthesis triglycerides in the liver and adipose tissue and stimulates lipolysis. Therefore, it is postulated that leptin deficiency is responsible for the metabolic disorders that occur in lipodystrophy. Clinical trials indicate the possibility of using recombinant leptin – metreleptin to supplement the hormone deficiency. In patients with various types of lipodystrophy, normalization of glucose, triglycerides and HDL cholesterol levels was observed after the use of metreleptin. In addition, patients reported a decrease in appetite and, as a result, a decrease in BMI with no significant side effects of the drug. Accordin","PeriodicalId":20347,"journal":{"name":"Postȩpy higieny i medycyny doświadczalnej","volume":"75 1","pages":"815 - 822"},"PeriodicalIF":0.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69108446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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